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Medicine Science

COVID Pandemic Aged Brains By an Average of 5.5 Months, Study Finds 32

An anonymous reader quotes a report from NBC News: Using brain scans from a very large database, British researchers determined that during the pandemic years of 2021 and 2022, people's brains showed signs of aging, including shrinkage, according to the report published in Nature Communications. People who got infected with the virus also showed deficits in certain cognitive abilities, such as processing speed and mental flexibility. The aging effect "was most pronounced in males and those from more socioeconomically deprived backgrounds," said the study's first author, Ali-Reza Mohammadi-Nejad, a neuroimaging researcher at the University of Nottingham, via email. "It highlights that brain health is not shaped solely by illness, but also by broader life experiences."

Overall, the researchers found a 5.5-month acceleration in aging associated with the pandemic. On average, the difference in brain aging between men and women was small, about 2.5 months. "We don't yet know exactly why, but this fits with other research suggesting that men may be more affected by certain types of stress or health challenges," Mohammadi-Nejad said. [...] The study wasn't designed to pinpoint specific causes. "But it is likely that the cumulative experience of the pandemic -- including psychological stress, social isolation, disruptions in daily life, reduced activity and wellness -- contributed to the observed changes," Mohammadi-Nejad said. "In this sense, the pandemic period itself appears to have left a mark on our brains, even in the absence of infection."
"The most intriguing finding in this study is that only those who were infected with SARS-CoV-2 showed any cognitive deficits, despite structural aging," said Jacqueline Becker, a clinical neuropsychologist and assistant professor of medicine at the Icahn School of Medicine at Mount Sinai. "This speaks a little to the effects of the virus itself."

The study may shed light on conditions like long Covid and chronic fatigue, though it's still unclear whether the observed brain changes in uninfected individuals will lead to noticeable effects on brain function.

COVID Pandemic Aged Brains By an Average of 5.5 Months, Study Finds

Comments Filter:
  • by bjoast ( 1310293 ) on Tuesday July 22, 2025 @11:33PM (#65538340)
    We don't need brains anymore. We have AI.
  • One of the reasons heparin, a blood thinner, was used for more severe Covid-19 infections was that the smallest arteries of the body, including the brain, tended to become clogged with products of the virus' effects on the body. Blood vessel problems are more common in males, and arterial blood vessel disease of various types are a known risk factor for brain "aging", cognitive impairment and dementia. This suggests the hypothesis that the "aging" effects of Covid-19 on the brain are mediated by effects
    • Great - fighting pseudoscience with pseudoscience.
      • The only potential fight I see (and one that isn't needed here) is the one you may be trolling for.... :)
      • by Rei ( 128717 )

        A quick AI-deepsearch doublecheck suggests that this isn't at all pseudoscience, so care you defend your argument?

        An analysis of scientific and medical research largely supports the provided statement, with some nuances. Here's a breakdown of the fact-checked claims:

        Heparin Use in Severe COVID-19

        The statement claims that heparin, a blood thinner, was used for more severe Covid-19 infections because the smallest arteries, including those in the brain, tended to become clogged.

        This is largely accurate. Severe

        • by Rei ( 128717 )

          I'll personally never get over how surprised people are to hear that COVID affects the cardiovascular system. The spike protein literally targets ACE2. That's its point of entry. ACE2 is a blood-pressure regulatory surface protein (Angiotensin-Converting Enzyme 2 - angiotensin is a vasoconstrictor), expressed by cells that need to modulate the cardiovascular system. Pulmonary-related deaths were the #1 cause of death from COVID, but cardiovascular-related deaths were #2 or #3 (depending on whether you co

  • Shouldn't a bit of additional aging be a good thing?

    (Of course, not for our elected leaders. The average age of Congress is airline-pilots-would-be-forced-to-retire high...)

    • Old and senile people are as infantile as petulant children, hence nope, we definitely don't need that.

    • I recall Mad magazine long ago having a piece on a family trip or tour to DC. "Next, we're going to see a fossil collection." "Are we going to the Smithsonian?" "No, we're visiting the Supreme Court."
  • Shrinkage? (Score:3, Funny)

    by 93 Escort Wagon ( 326346 ) on Wednesday July 23, 2025 @02:03AM (#65538498)

    I was in the pool!! I was in the pool!!

  • This is yet another reason to reverse the decades of women retiring earlier than men to having men retiring earlier...

  • by StormReaver ( 59959 ) on Wednesday July 23, 2025 @06:39AM (#65538858)

    But it is likely that the cumulative experience of the pandemic -- including psychological stress, social isolation, disruptions in daily life, reduced activity and wellness -- contributed to the observed changes...

    My brain have have reversed in age during the pandemic:

    1) Psychological stress. I have never been happier in my entire adult life as I was during the pandemic. Working from home became the accepted norm. I didn't have to deal with shitty workplace offices (they are all shitty, without exception). I got to watch my kids grow, rather than only witnessing a small sliver of it. My wife and I got much more time with each other, which let us bond more than we had ever been able to bond in the past. Online shopping became the norm, etc. My stress level went down by an order of magnitude. My entire family got COVID, were bed-ridden for a day or two, then recovered like nothing happened. I hadn't slept that well in years, and my wife and I were supposed to be in the high-risk of death category. The pandemic years were the best years of my entire adult life, and they ended all too soon.

    2) Social isolation: I was able to get away from people in general. Talk about mental rejuvenation! I had my wife and kids with me, which is all the socialization I need and want. I had the Internet for entertainment and education, and whatever socialization I wanted. Better yet, I could end socialization as needed and wanted. I was able to measure out what little socialization I wanted, and end it when I had enough. It was great.

    3) Disruptions In Daily Life: Daily life requires all the things I don't want, so changing it was highly welcome. My stress level (and blood pressure) went way down during the pandemic. The worse part of the disruption was when it ended. Going back to daily life has raised my stress level (and my blood pressure) again.

    4) Reduced Activity And Wellness: I lost 40 pounds during the pandemic due to increased and regular exercise, and due to greatly reduced stress. My blood pressure went down, my bonding with my family increased, and every metric of wellness I can think of improved (including my blood lipids). They were the golden years of middle-aged wellness.

    If these are the markers for brain aging, my brain must have reversed aging by a few years. Bring on the next pandemic!

    • Why weren't you able to make a single one of those improvements on your own? From your writing it sounds like life was wearing you down. But you waited for other people to make change. They did and you got happy. They changed back, and you again just went along with society, despite how much you are aware of it harming you. You're probably just like everyone else, stuck in the rat race. Does this seem like you? https://www.youtube.com/watch?... [youtube.com]
    • Yeah...the pandemic was apparently great for those with crippling social anxiety and depression. The problem is, most of us aren't like that.
    • My brain [may] have reversed in age during the pandemic:

      An alternative hypothesis is that you suffered brain damage that altered your perception.

  • Oh please — can we finally stop blaming every imaginable human struggle on Covid? The way the media talks, you’d think the virus turned the whole planet into a psychiatric ward overnight. Brains shrank, IQs collapsed, society unraveled — give me a break. Nothing changed for me except fewer flights and a piece of cloth on my face. I didn’t spiral into madness, I didn’t “age five years overnight,” and I certainly didn’t become a shell of my former self because o
  • just because you "got over" a disease, it doesn't mean you're "better". Not all damage just goes away. It seems every month brings a new discovery about some disease is brought about or greatly increased in likelihood from past infection. For example, my mother suffers greatly from Sjögren's (incl. neuropathy where it feels like her skin is on fire). There's now increasing evidence pointing to it and related diseases as being at least in part triggered by Epstein-Barr, and my mother has strong diagno

  • by avandesande ( 143899 ) on Wednesday July 23, 2025 @11:34AM (#65539476) Journal
    So the pandemic was 2 years and my brain aged 5.5 months? Is COVID the new Nootropic?

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