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Medicine

Moderna Says mRNA Flu Vaccine Sailed Through Trial, Beating Standard Shot (arstechnica.com) 153

Moderna's mRNA-based seasonal flu vaccine proved 27% more effective at preventing influenza infections than standard flu shots in a Phase 3 trial involving nearly 41,000 people aged 50 and above, the firm said this week.

The company announced that mRNA-1010 had an overall vaccine efficacy that was 26.6% higher than conventional shots, rising to 27.4% higher in participants aged 65 and older during the six-month study period. The 2024-2025 flu season hospitalized an estimated 770,000 Americans, according to the Centers for Disease Control and Prevention.

Moderna Says mRNA Flu Vaccine Sailed Through Trial, Beating Standard Shot

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  • by ndsurvivor ( 891239 ) on Friday July 04, 2025 @07:32PM (#65497936)
    I am still alive. I think they are a quality company.
    • So did I. I felt like shit the next two days but never had Covid, AFAIK.
      • by gweihir ( 88907 )

        Same here. But I think my immune system mioght have fought it off several times this year and I know several people that got really sick with a "bad flu" at a time where the flu should not be a thing. That would not have gone so well for me without those vaccinations.

    • Well... statistically this could be attributed to survival bias. The ones that died no longer can comment on Slashdot. But before I start a needless discussion, my whole family did all the shots and we all live. Wait...
    • My neighbor got the Moderna COVID vaccine and 3 hours later was fighting for his life. He was laid up in the hospital for weeks and never compensated. RNA vaccines are the wrong direction. Make the COVID vaccine egg based and my family will take it.

  • by ffkom ( 3519199 ) on Friday July 04, 2025 @08:00PM (#65497972)
    ... with pretty good results in clinical trials, but they never entered the market for probably the same reason why they won't enter the market now: Because they are more expensive than the penny-pinched chicken-egg based flu vaccines. For the same reason, we see mRNA vaccines manufactured with cool new "RNA printers" only in clinical trials, while the stuff for the masses is then manufactured based on the usual bacterial GMO fermentation... resulting in much less pure products.
    • by Nebulo ( 29412 )

      Well, we've dramatically ramped up our mRNA vaccine manufacturing capacity due to COVID - perhaps this time they will be more competitive.

    • by AmiMoJo ( 196126 )

      It's yet another example of something that governments should be funding. The flu costs billions every year in lost productivity, and lost sales as people stay home. In the UK you can already get the flu shot for free, paid for out of taxation, because it's understood that the cost is less than the benefit to the economy and the tax take.

    • Did it have better persistence across different strains of influenza? Normal flu vaccines perform quite badly in that department.

      • by ffkom ( 3519199 )
        That was not tested (or possible to test for) in that 2015 clinical trial, as it would have required a way larger tested population over a longer time and/or a larger geographical distribution.
        It is plausible to assume that mRNA technology does, in theory, provide the option to more quickly adapt to new variants or to select target sequences that are known to be more common among the different strains. But as we have experienced already with the different Sars-Cov-2 variants, that does not mean it is feasi
  • But not in the US (Score:5, Insightful)

    by SoftwareArtist ( 1472499 ) on Friday July 04, 2025 @08:25PM (#65498020)

    Sadly, this won't be coming to the US any time soon. RFK Jr. has arbitrarily declared that future vaccines will only be approved if the control group in the trials got an inactive placebo. Why? No reason at all, it's just an absurd requirement he made up. The control group in this trial got a conventional flu vaccine instead of a placebo (which would have been unethical), so it doesn't count.

    • Sadly, this won't be coming to the US any time soon. RFK Jr. has arbitrarily declared that future vaccines will only be approved if the control group in the trials got an inactive placebo. Why? No reason at all, it's just an absurd requirement he made up. The control group in this trial got a conventional flu vaccine instead of a placebo (which would have been unethical), so it doesn't count.

      Medical care is quickly becoming illegal.

    • you pay attention too much. i kid, however, just hang out a little bit and your very extraordinary point that you have will be fixed and settled.
    • by VaccinesCauseAdults ( 7114361 ) on Friday July 04, 2025 @08:48PM (#65498072)

      So the US Secretary of Health effectively wants to lower the threshold for approving treatments from “it’s better than existing medicine” down to “it’s better than nothing”?

      In fact it’s worse: he wants to lower the threshold to be “it’s better than nothing but apart from that we haven’t compared it to anything (because we aren’t allowed to).”

      Just wow. Go science!

    • What's the matter? Aren't you willing to accept the advice of a 14 year long heroin addict for expertise health advice?

    • That's okay King Trump will protect me from the viruses. And hurricanes. Both of which using nukes.
    • Re:But not in the US (Score:5, Informative)

      by tlhIngan ( 30335 ) <{ten.frow} {ta} {todhsals}> on Friday July 04, 2025 @10:10PM (#65498184)

      Sadly, this won't be coming to the US any time soon. RFK Jr. has arbitrarily declared that future vaccines will only be approved if the control group in the trials got an inactive placebo. Why? No reason at all, it's just an absurd requirement he made up. The control group in this trial got a conventional flu vaccine instead of a placebo (which would have been unethical), so it doesn't count.

      He's relying on the double blind studies for effectiveness. New drugs go through the double blind test - where you have a control group and a test group, and the participants - both the people who give the medications and record the results as well as the patients don't know who got what. This is considered "gold standard" research.

      (There is also the "single blind" study, where only the patients don't know if they're getting the drug or the placebo, but the people giving it to them do know. This is of lower quality since there may be inadvertent communication that tells the patient what they're actually getting)

      Of course, you can't do true double blind studies of vaccines, because it's unethical to tell someone they're getting the flu shot and then not give it to them so they believe they're protected against the flu when they really aren't. And the flu can kill, it sends people to hospital all the time (it did to me, and gave me a permanent heart condition). So it's basically impossible to do a double-blind study of vaccines. It's possible to judge the effectiveness of it though through a non-blinded study (the participants know if they're getting the shot or not) - simply by observing if the people who come in with flu symptoms and asking if they got the shot or not.

      Of course, that's the worst kind of study, but it's the only one that can be ethically done for vaccines - they are a choice, and many people choose to get the shot, while others choose not to and you can compare how the two populations did. We've traditionally used Australia and New Zealand for these studies because their peak flu season happens during "our" summers so we can tell their effectiveness or lack thereof.

      RFK Jr. Is just being smart. He knows it's unethical to do a double-blinded vaccine study, so he's throwing it in the face of researchers and simply using "gold standard research" as a way to promote anti-vax beliefs.

      • by tlhIngan ( 30335 )

        Of course, one could also ask about the lack of requirements for double-blind studies for things like homeopathy and for the alternatives to vaccinations he promotes.

      • Re:But not in the US (Score:5, Informative)

        by SoftwareArtist ( 1472499 ) on Friday July 04, 2025 @10:48PM (#65498254)

        A double blind study means neither the patient nor the doctor knows whether they're in the treatment group or the control group. It has nothing to do with what is used as the control. When there's an existing safe, effective vaccine, you always use that for the control group. It would be unethical not to. It's still a double blind study, because the patient still doesn't know whether they're getting the new vaccine or the old one. And it makes the resulting data stronger, not weaker. It tells you whether the new vaccine is more effective than the old vaccine, not just whether it's more effective than no vaccine at all.

        When there's no existing vaccine, then you use an unrelated vaccine as the control. That's essential. If you used an inactive placebo as the control, and a patient felt tired and achy the day after getting the shot, they could be pretty sure they were in the treatment group. That knowledge could affect their behavior and bias the results. So instead you use an unrelated vaccine with similar side effects as the control, so the patient can't infer which group they're in from side effects. This is standard practice.

        But RFK has arbitrarily declared that won't be accepted. Instead you must use an inactive placebo, even though that gives worse quality data.

      • Re:But not in the US (Score:4, Informative)

        by mesterha ( 110796 ) <<moc.liamg> <ta> <mrahretsem.sirhc>> on Friday July 04, 2025 @10:51PM (#65498256) Homepage
        He's demanding the control be a placebo which is a different issue. In this case, there is no reason to make the control a placebo.
        • In fact, it is UNETHICAL to use a placebo control in any clinical trial of an investigational product for which the existing standard of care already includes a product on the market.

          In plain English, it is entirely unethical to give participants a placebo to test the efficacy of a new flu vaccine when we already have existing vaccines on the market. Doing so denies participants in the study from accessing effective treatment. If you have to test against a placebo, it will be impossible to recruit partici

    • Re:But not in the US (Score:5, Interesting)

      by newcastlejon ( 1483695 ) on Friday July 04, 2025 @10:16PM (#65498196)

      vaccines will only be approved if the control group in the trials got an inactive placebo. Why? No reason at all, it's just an absurd requirement he made up.

      I wouldn't be so sure that it was RFK's idea, but the effect is to stifle research. People working on new drugs and vaccines will be less willing to carry out tests subject to this restriction because it means knowingly putting the lives of the placebo group at risk. That makes it rather unethical I'd say. Compare this to a situation where the is no "current" treatment available to test against; the placebo group in that case face just the same risk as they would if the trial didn't happen.

    • Sadly, this won't be coming to the US any time soon.

      I'm guessing in about 3.5 years. :-)

  • So 27% more effective. I hear moving from 32b to 64b mircochips gives a 20 to 30% performance boost. Coincident?
  • I know an anecdote is not data, but after my Covid booster, I did have myocarditis. That really should not happen. I did not risk any further mRNA Covid vaccinations.

    I hope they solve that problem...

  • by Fons_de_spons ( 1311177 ) on Saturday July 05, 2025 @01:30AM (#65498438)
    I was disappointed that my arm was not magnetic after my covid shots. I hoped the effect would kick in after a few boosters, but no. Had to buy a magnetic arm wrist to carry my tools.
    Does this one perform better in that aspect?
  • ... what if I want to catch a preventable disease, feel like absolute shit for a week, probably infect others, and enjoy a not insubstantial chance of complications or death? All so I can save $20 which I can spend on bronze tier membership in the RFK jr death cult. Take that big pharma and your medicine.
  • The tradidional flu vaccine is ok (have had shots every time for 20 years now), but it is time for a more capable successor. Seems this one is it. Good.

  • by zkiwi34 ( 974563 )
    The mRNA vaccines didn't stop anyone getting Covid, multiple times. Even Biden got it at least twice. And any evidence that it mitigated symptoms doesn't stand up to scrutiny.
  • All they want to do is get your money. Like car companies creating seatbelts, air bags and ABS they just cost money and they are out to get yours. Stop using these things. It's all a big conspiracy.
    You see big pharma control the government and make them try to force medicine on you...but you're too smart for that. Government can't tell you what to do right?! Force medicine INSIDE your body?? No no! Not like you have to produce your ID or passport anywhere or stop at red lights because government can't tel

"You don't go out and kick a mad dog. If you have a mad dog with rabies, you take a gun and shoot him." -- Pat Robertson, TV Evangelist, about Muammar Kadhafy

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