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Medicine United States

GLP-1 Drug Use Surges 600% as 2% of Americans Take Weight-Loss Medications (axios.com) 150

An anonymous reader shares a report: More than 2% of Americans are taking the blockbuster class of GLP-1 drugs for overweight or obesity, up nearly 600% over six years, according to a report from FAIR Health given to Axios first. The data from FAIR Health's repository of over 51 billion commercial healthcare claim records shows the explosion in use of the drugs specifically for weight loss -- roughly half of all users.

In all, roughly 4% of Americans were taking GLP-1 drugs in 2024 for either overweight, obesity or Type 2 diabetes (their original approved use). The data shows Novo Nordisk's Ozempic is still by far the most commonly taken GLP-1, followed by Eli Lilly's Mounjaro. The percentage of adults who were prescribed a GLP-1 drug but did not have bariatric surgery increased from 2.5% in 2019 to 11.2% in 2024 while the the percentage of adult patients who had bariatric surgery decreased 41.8%.

GLP-1 Drug Use Surges 600% as 2% of Americans Take Weight-Loss Medications

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  • by Anonymous Coward

    make it a national priority to get it into the hands of as many obese americans as we can, the cost savings to the nation would be enormous, more than pay for itself. use the NDA to nationalize the formula, whatever it takes

  • by SlashbotAgent ( 6477336 ) on Tuesday May 27, 2025 @12:51PM (#65407823)

    I hope that there are no delayed ill effects form these drugs. I don't want to hear that they cause cancer or bonitis. If such a negative effect were found, the injury law ads will drive us all insane.

    • There's already problems, but I'm not taking these because I expect more problems. Being fat is bad but it's not the only bad possibility.

    • by TheWho79 ( 10289219 ) on Tuesday May 27, 2025 @01:21PM (#65407911)
      The side effects are tolerable (occasional upset stomach and constipation - and a few report increased hair loss).

      The benefits go beyond weight loss:

      • a1c is reduced
      • reduction in major cardiovascular events (reduces heart attacks)
      • many people report stopping lifetime addictions (studies being done - i quit moderate drinking - cold with out trying or wanting too)
      • Neurodegenerative Diseases - neuroprotective effects, including in conditions like Alzheimer's disease ( https://www.cas.org/resources/... [cas.org] )
      • If your drinking was moderate, I suspect it wasn't an addiction.

      • by dfghjk ( 711126 )

        You clearly haven't taken it. Thanks for the expertise.

      • The side effects are tolerable

        I guess if you find sudden blindness [webmd.com] tolerable....sure.

      • many people report stopping lifetime addictions

        Causality issue. A body change often results in major changes in behavioral as well, part of that being motivating. There's strong correlation between people going to the gym and stopping lifetime addictions as well, having children and stopping lifetime addictions. It stands to reason that if you struggled with weightless and suddenly loose weight you become uniquely motivated in other ways.

        The A1C is a bit more difficult since it seems to recover faster than the body loses weight, but the rest of your lis

      • by mjwx ( 966435 )

        The side effects are tolerable (occasional upset stomach and constipation - and a few report increased hair loss).

        The benefits go beyond weight loss:

        • a1c is reduced
        • reduction in major cardiovascular events (reduces heart attacks)
        • many people report stopping lifetime addictions (studies being done - i quit moderate drinking - cold with out trying or wanting too)
        • Neurodegenerative Diseases - neuroprotective effects, including in conditions like Alzheimer's disease ( https://www.cas.org/resources/... [cas.org] )

        If you're a type 2 diabetic, the already observed benefits outweigh the as yet unidentified nebulous risk. Real risks like retinopathy, heart and liver issues are reduced.

        The main job of GLP-1 agonists is to lower blood sugar levels so the benefits realised from this are pretty great. The weight loss and appetite suppression was just a beneficial side effect, however as an observed side effect it's also being used to treat obesity.

        I think there is a bit of an issue with these being used as a lifesty

    • It has been used by people since 1992. In large quantities since 2000 - approved widely by 2005 (exenatide) - then the rest full final approved a couple years ago. If this was a long term side effect issues - they would have shown by now.
  • by TheWho79 ( 10289219 ) on Tuesday May 27, 2025 @12:53PM (#65407829)
    As someone who's been active and over weight for 30 years, this is a miracle drug. I tried everything from running marathons for five years (put on weight doing it), to working out and nothing helped. I'd loose 20lbs, and put on 30 - lose 30, and put on 40. I estimate I've lost over 250lbs over the last 30 years - unfortunately, I'd gained 350. Meanwhile, lost 110lbs in 2023 on mounjaro.
    • As someone who's been active and over weight for 30 years, this is a miracle drug. I tried everything from running marathons for five years (put on weight doing it), to working out and nothing helped. I'd loose 20lbs, and put on 30 - lose 30, and put on 40. I estimate I've lost over 250lbs over the last 30 years - unfortunately, I'd gained 350. Meanwhile, lost 110lbs in 2023 on mounjaro.

      If you are overweight and running marathons I'd venture a guess you are healthier than the other 99% of overweight people.

    • by e3m4n ( 947977 )

      The only recent news tied to these drugs is a report of significant muscle loss. Though Im not sure its a direct cause as much as a result of a loss of appetite. I had to switch from Ozempic to Mounjaro because I could not eat more than 3-4 min on Ozempic before I was completely turned off to the idea of eating. It was hard keeping the protein intake up. Mounjaro doesnt have quite as strong an effect. Ive recently ramped up to 12.5 and just now am beginning to see a similar curb to cravings. I bet they coul

      • I was near 280 when I started in 2022. Now at 165 and stable for over a year. You know how much muscle it took to carry around 115lbs? Ya, you are going to lose a little of that during weight loss - so what.
        • If you've reached your goal, do you have to keep taking it?

          • I'm under the impression that you must stay on it ... if you stop , your body goes back... you gain back faster I read.

            Sounds an awful lot like addiction to me. Similar in that you must stay on it to maintain your new weight... maybe just closer to a subscription .. An ideal commercial product, no?
        • by dfghjk ( 711126 )

          Not a problem for me, so fuck anyone else, amirite?

      • The reports of "muscle loss" would be expected in any weight loss program. You also get significant muscle loss from restricting calories. However, combining the drug with strength training should mean your overall body composition improves while on the drug.

        • by e3m4n ( 947977 )

          Without sufficient protein your body will eat its own muscle including your heart. At least 0.5g protein per lb lean body mass. The drug can make 75g a day difficult.

    • by Zarhan ( 415465 )

      I have sort of the same deal. I hate "exercise" without any real purpose than busy-work, but I still started swimming around 5 years go. I typically swim about 1 km three times a week. I chose swimming because at least you don't sweat while doing that (or rather, it goes directly to the pool) and you get to do different styles to alleviate some of the boredom.

      Result: Weight has been exactly the same as before I started, around 100 kg. Bloodwork shows that cholesterol levels and other indicators are much bet

    • by AmiMoJo ( 196126 )

      There are cognitive benefits too. You don't have to think about food and eating. It's a load off your mind, a worry removed.

  • New treatment to solve an old problem.
  • If 4% of the population is taking the drugs because of overweight, obesity, or Type II diabetes, then 4% of the population is taking the drug to lose weight. 95% of that other 2% got diabetes because they are overweight.
  • Call it the Fat Vaccine and *boom* shortages of these drugs all solved ;-)
  • Problem solved.

  • My wife has noticed that a number of friends that used to be, well, not skinny, have been looking a little trimmer these days. Who remembers "Does she or doesn't she?"? There's a new twist on that old ad.
  • by printman ( 54032 ) on Tuesday May 27, 2025 @03:22PM (#65408389) Homepage

    About 70% of the food in a US grocery store, and pretty much all food at restaurants, has added sugar (even *salt* has added sugar these days as an "anti-caking" agent...) Stop adding sugar to everything...

    • That's great to say. Tell it to the food companies. The average American doesn't have a choice in the matter when they're adding it to all the food.
      • Tell it to the food companies

        Why do you get food from a company? Personally I go to things such as butchers, or grocers. You want to make spagbol, how about not getting a bottle of Bolognese sauce and instead stop by the butcher for some mince and get some vegetables herbs and spices.

        Stop blaming the food companies for your own inadequacy. If you don't have the time to cook then come out and say you don't have time to cook. No one is injecting tomatoes with sugar.

    • As for the added sugar in iodized salt, please keep it.

      "Dextrose is added to keep the potassium iodide from oxidizing and being lost. Potassium iodide is added as a dietary supplement."

      I'll leave you to look up goiter on your own, as well as 'goiter belt'.

  • Honestly who wouldn't like to take a pill and be slender again?
    Every time I've lost weight, I've gained more back to the point I'm afraid to try. Last time was 10 months, no treeats, swimming a mile every evening after work, going to bed by 9, halving any food I was served. I lost 25lbs to get to 270...and when I thought "ok maybe I can ease up and just maintain" I quickly ballooned 50lbs.

    But with these drugs I'm genuinely concerned what the long term effects will be.

    OTOH, the long term deleterious effect

    • I'm not sure that I would take it just for weight loss, but the anti-diabetic effects have been a godsend for me.

      In my case, Ozempic has taken me from needing to inject insulin constantly to not needing insulin at all. Those who've never had to do this have no idea what a pain in the ass* it is. It's not just the injections, it's carrying the paraphernalia -- insulin (making sure it never gets overheated), needles, blood glucose meter and lancets, alcohol pads, emergency meds in case your blood sugar goes T

Do you guys know what you're doing, or are you just hacking?

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