Bird Flu Fears Stoke the Race for an mRNA Flu Vaccine 101
Concern over potential human-to-human transmission of bird flu has risen after six Missouri healthcare workers developed mild respiratory symptoms following contact with a patient infected with H5N1. The CDC reports only the original patient has tested positive for the virus. Scientists are ramping up efforts to develop mRNA vaccines against H5N1, with researchers at the University of Pennsylvania and major pharmaceutical companies like Moderna, Pfizer, and GSK leading the charge. While mRNA technology offers rapid vaccine production, clinical trials have shown mixed results, particularly against influenza B strains. Wired adds: [...] Traditionally, flu vaccines contain inactivated viruses that are grown in hens' eggs. This works reasonably well, but it takes a long time to make such jabs, which means health authorities have to publish their predictions about which strains of flu will be circulating during the upcoming winter well in advance. If you could manufacture vaccines more quickly, you could make more accurate predictions nearer to flu season.
Not only that, researchers hope that a single mRNA shot could one day target 20 or more strains of flu at once, relieving the need for some of this guesswork. Scher's colleagues are working on such a "universal" flu vaccine. With clinical trials ongoing, it's still early days. Sheena Cruickshank, an immunologist at the University of Manchester, has watched reports about emerging mRNA flu jabs with interest but says that questions remain. "We don't yet know how long-lasting the immunity they produce is," she says. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, concurs, though he notes that all flu jabs, regardless of how they are made, have a waning immunity problem -- your protection could decline by around 10 percent every month following injection.
Not only that, researchers hope that a single mRNA shot could one day target 20 or more strains of flu at once, relieving the need for some of this guesswork. Scher's colleagues are working on such a "universal" flu vaccine. With clinical trials ongoing, it's still early days. Sheena Cruickshank, an immunologist at the University of Manchester, has watched reports about emerging mRNA flu jabs with interest but says that questions remain. "We don't yet know how long-lasting the immunity they produce is," she says. Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, concurs, though he notes that all flu jabs, regardless of how they are made, have a waning immunity problem -- your protection could decline by around 10 percent every month following injection.
Don't believe the hype (Score:1, Troll)
Yes please, sign me up to take untested medication to help with my cold.
Yikes!
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https://en.wikipedia.org/wiki/COVID-19_pandemic_death_rates_by_country [wikipedia.org]
https://www.cdc.gov/flu/vaccines/keyfacts.html [cdc.gov]
Logic of the insane "Companies only want to get richer off this!" meanwhile "privatize schools!" and "private companies should do this work!" (hint: you should look at the cost difference)
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Except in Japan which had a very low transmission rate before the Covid shots were released
That's because Japanese people readily wear masks when they're sick to prevent others from getting sick. For them, putting on a mask to prevent getting sick is second nature.
Unlike in the U.S. where it was the most difficult thing in the world to do.
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I am still amazed at how many people, even in my own entourage, keep on insisting that masks are a PPE (with the corollary that it does not work as PPE) and not source control.
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Unlike in the U.S. where it was the most difficult thing in the world to do.
Unless you're in the KKK or white supremacists. https://www.wgal.com/article/h... [wgal.com]
Oh and spare me the "they're feds" bullshit. Which federal agency is this? Why would they cosplay as nazis, to make the right wing look bad? The right wing certainly doesn't need any help there. https://www.npr.org/2024/09/10... [npr.org]
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You're comparing primary education and mRNA vaccine development. Impressive.
Stupid, but impressive. If privatizing education is bad, why is privatizing medicine NOT...? Oh, cause the government does such a great job.
Re: Don't believe the hype (Score:2)
Nature also gives no indication any of the 6 workers had bird flu as all their tests for it came back negative.
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In other news, have you heard that the earth is spherical & orbits around the sun? Oh, & that the USA has successfully landed several manned missions on the moon? Oh, & Donald Trump didn't win the 2020 election; Biden won it fair & square?
That should keep you busy for a while
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What fiasco? The vaccine has been proven effective [cdc.gov] and has saved many lives.
Are you talking about the sensationalist headlines that made it sound like the vaccine killed more people than it saved, when in fact (if you read the articles that had those headlines) they said the exact opposite? They used clever wording and statplay to creating a shocking headline that simply didn't mean what it seemed to mean.
Or maybe those predictions of a mass die-off two years after getting the vaccines, which turned out t
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The most successful vaccines there are -- measles vaccines -- don't prevent the spread of measles in the sense you are apparently using the word. They reduce the spread enough so we can go about our business.
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Why would Donald Trump do such a thing? https://trumpwhitehouse.archiv... [archives.gov]
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can't believe someone will take any vaccine after the covid fiasco
I can't believe that the CIA and NSA haven't rooted out and jailed or killed you FSB agents sent to the U.S. to cause chaos.
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The covid vaccine is one of the most tested and closely studied vaccines in history. Plus mRNA has was discovered in the 60s and research started in the 90s. https://publichealth.jhu.edu/2... [jhu.edu]
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Did you ride this bus to school? https://marktindle.com/2015/11... [marktindle.com]
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Good luck (Score:1)
I think it will be hard to do without collateral damage. Influenza is a very persistent virus that humanity tolerates very well. So there are possibly a lot of molecular mimicry risks where if you target the wrong protein, you're going to have a vaccine induced autoimmune disease. It sort of happened with the ACE2 receptor and COVID, but considering how widespread the virus itself was the side effects were more likely to happen from the real virus than a vaccine.
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Is that article funded by big pharma?
What vaccine article, isn’t.
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Why does th
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Dr. Malone's statements have been thoroughly debunked [factcheck.org] by the ultimate authority of all scientific discussions: evidence.
That's the kicker. He offered his statements without any evidence at all, and couldn't supply any later when asked for some. And, as it turns out, evidence was available, and it flatly refuted his claims.
Your statement is a good example of fallacious reasoning. You believed his claims were true because of who he was. His degrees and other accomplishments. But such facts about the spea
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How dare companies try to find a way so people don't get sick or die. The outrage! We should let nature take its course and have tens of millions die [wikipedia.org] from a simple cold. Right now only about 50,000 people die each year, let's crank those numbers up and really drive the economy into a tailspin.
Umm, I think you have it backwards. Companies are in the game to make money. The pharma industry literally makes money from you being sick Seriously, take the rose tinted glasses off and have another look around.
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The pharma industry literally makes money from you being sick
And farmers earn money from you being hungry. IT'S A CONSPIRACY!!!! Farmers are making people hungry!
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mRNA technology has been around for around 50 years [jhu.edu], longer than you've been on this planet. It's been used in multiple applications [nih.gov] during that time.
Now go collect your vodka or however you're being paid seeing how Russian companies have to resort to bartering [newsweek.com] because they don't have the money.
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Interesting (Score:2)
1. You point to a dubious source that shoveled mountains of lies on the subject for YEARS (the NIH) to make a claim that mRNA tech has been around for 50 years... but THAT'S NOT WHAT THAT WEB SITE SAYS. Even the NIH admits that while the subject has been STUDIED for many years, "Phase 1 clinical trials to test the safety of mRNA vaccines for Nipah virus; the trials began in 2022" and the rest of that page goes on and on about the [failed] COVID-19 vaccine.
Why do I say "failed" COVID-19 vaccine?
Remember when
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I'm no expert, but from what I understand
Good. Stop talking then.
Re: Just Say No to mRNA (Score:2)
Like the time you took wild guesses in slashdot comments? I guess rules for thee but not for me. You must have been the hit of parties during the plandemic
Re: Just Say No to mRNA (Score:2)
Related link: https://m.slashdot.org/thread/64835783
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Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof; or abridging the freedom of speech, or of the press; or the right of the people peaceably to assemble, and to petition the Government for a redress of grievances.
Betting pool on (Score:1, Troll)
1. How fast the 5G conspiracy theories get revived.
2. How fast the democrats will push to make it a mandatory condition of stepping outside your door.
3. Whether or not it actually works better for the regular ol flu than the shit they hand out now.
Discuss
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#1 is the fault of a conservative media that revels in giving life to things like 5G conspriracies, they own that one.
How fast the democrats will push to make it a mandatory condition of stepping outside your door.
Yeah ok, conservatives from small folks to right to the largest media figures told us for what, a year or two, that Federal mandates would be a thing and how any day now, how it didn't work and how there would an upcoming wave of side effects all the way to mass death.
None of this happened and they get to just brush past it and pretend they never said all those things with conviction, so are
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Nah, the victim card doesn't work anymore, conservatives have milked that long enough.
The largest alterantive media influencers, channels, podcasts with viewbases in the millions and millions and their continued dominance of local news and talk radio means I don't have to listen to what MSNBC is saying, you can throw a rock and hit a piece of conservative media.
No more hiding behind the "mainstream media" charade like they are some oppressed counterculture, conservatives speak for themselves, loud and clear
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Before I explain, I have to ask, as a libertarian, who are you voting for?
As we famously know there are many types, it's kinda their whole deal.
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Libertarians are just republicans that don't want to pay taxes.
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We do not need to, we get a very good dose of both extremists sides here on slashdot.
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Try to learn one day the difference between "what conservative media are saying" and "what MSNBC says conservative media are saying". The world will suddenly make a lot more sense, I promise.
Trump verbatim from the debate. https://abcnews.go.com/Politic... [go.com]
In Springfield, they're eating the dogs. The people that came in. They're eating the cats. They're eating -- they're eating the pets of the people that live there. And this is what's happening in our country.
Re: Betting pool on (Score:4, Interesting)
But they did get to limit what drugs women can put in their body. So partial win??
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I asked first.
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I didn't say "you" said those things, I said conservatives and more specifically their media said those things.
This was mainstream stuff, I was alive 2020-2022, RFK, one of the most notable antivax people is a top advisor to the Republican candidate. This is not extreme anymore.
The mass death death thing like all the conservative conspiracy stuff (your qanons for example) just gets mindwaved away into the now more reasonable position and we all forget about that other stuff that never happened.
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The mass death death thing like all the conservative conspiracy stuff (your qanons for example) just gets mindwaved away into the now more reasonable position and we all forget about that other stuff that never happened.
That's because your constantly trying to smear one person with the the most extreme batshit crazy stuff you can find because you claim they are on the same side. They aren't. Look around you? I don't see too many Slashdotters aruging for "Conservatism" yet that's constantly your strawman. That's because you're clearly a partisan and you just want to sling the same mud you were shown how to by The Party.
Re:Betting pool on (Score:4, Funny)
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4. How fast the GOP will organise "flu parties."
Not 'troll'.
If the Marburg virus or Ebola virus started having human cases of them in the U.S., they'd have 'parties' to infect each other with those, too; call it 'evolution in action ' -- which is ironic as fuck, since most of them are 'creationists'.
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Conservatives walking around with my body my choice signs in regards to vaccines is the most hypocritical shit ever. https://www.npr.org/sections/h... [npr.org]
So does that count for abortions?
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Re:Betting pool on (Score:4, Informative)
2. How fast the democrats will push to make it a mandatory condition of stepping outside your door.
Do you have children in public schools? You must provide proof of vaccination before children can be enrolled. Nearly every employer in the medical field has vaccine requirements for employees. When you let religious nutjobs skip vaccines you get outbreaks, like this for example. https://www.nyc.gov/assets/doh... [nyc.gov]
Hell in 2000 the CDC declared measles eliminated, thanks to vaccines of course. https://www.cdc.gov/measles/ab... [cdc.gov]
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You're comparing two very different kinds of viruses. Traditional flu shots are only 40-60% effective on a given year because they rapidly mutate like coronaviruses do. They are still highly recommended. Even if you don't prevent illness, you reduce transmission. And even when there is transmission, you reduce severity.
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Tell me why mRNA is bad.
Re: Betting pool on (Score:2)
Cuz the gay frog chemtrailz. Duh.
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Re: Betting pool on (Score:2)
I do. And get ready to have your mind blown: they get their shots on time and on schedule. The exception to that is, like something like 3/4 of parents even in the blue districts, I didn't bother getting them covid shots given they all got covid (ranging from no symptoms to standard kid cold) before kiddie shots (with their mind-blowing 20-30% claimed efficacy) became available.
If I were to have another newborn now, maybe a covid shot would be in the cards. But not because some didshit at the CDC who flunke
I had the Death Vaxx (Score:1)
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Sometimes. Most vaccines are less than 90% effective.
You can look at per capita infection curves for all of these diseases and vaccines were introduced as they approached zero with little inflection of the curves. That's just the hard data.
Add in ethyl mercury sequestration and macrophage-mediated associated aluminum nanoparticle transport across the blood-brain barrier, SV-40 cancers, and the lack of PC-RCT's for modern vaccines with zero liability and the calculus isn't straightforward.
I went from an advo
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If you're worried about SV-40 today, then you didn't read carefully enough. That was contaminated polio vaccines from at least 60 years ago and really nothing to do with the vaccines themselves. Pretty sure they're gone now.
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Lots of vaccines don't provide total lifetime protection. You should get a tetanus booster every 10-years, rabies vaccines last a couple years, flu shots, etc.
Ten seconds of consideration might lead to you realizing you can catch a cold a couple times a year, but chicken pox will only infect you once. Its almost like the immune system doesn't behave the same way with every infection....
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Settle down grandpa. It's time for Wheel of Fortune and a mug of sleepy time tea.
Here we go again! (Score:1)
Aside from the above, also cue the people who will insist that whatever it is, is 'untested' and would rather wait YEARS for a so-callled 'traditional' vaccine, even if it's too damned late to do any good.
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Jumps to mammals ... (Score:2)
The current strain of H5N1 jumps to mammals regularly.
For example, dozens of tigers died in Vietnam [msn.com], and before that seals in Patagonia [apnews.com].
It is only a matter of time before it infects humans in significant numbers.
Oh, and by the way, this is zoonosis at work, no lab leak crappy hypothesis...
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Also, it doesn't prove that CV19 was Zoonotic and credible sources [perma.cc] (the Director of the FBI) say it wasn't. The most definitive article in Nature I could find didn't come down either way and the DNI also suspects a lab-origin.
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The FBI director's analysis and opinion is contradicted by a multitude of virologists, and epidemiologists and published scientific papers, which all point to a zoonotic origin. So it has little weight, if any.
Hereisthe most recent paper, analyzing DNA samples from a specific corner in the Wuhan market [msn.com].
Giving testing, would mRNA vaccine be quicker? (Score:2)
Sure, developing the new vaccine is faster but the long pole seems to be testing. That is why COVID vaccines and boosters are based on the strains circulating the previous winter. The 2022 version was available in September based on variants circulating in July. It was really cool because it was the only time most of us had access to a vaccine based on the currently circulating strain. However, they achieved this by going directly from animal testing to shipping product. No human testing. That was app
Most people not vaccinated (Score:2)
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No thanks (Score:2)
So, everyone who was pro vaccine mandate ( and many even went full Nazi with deny those people healthcare, put em in quarantine camps and let them die ) loved to parrot the phrase " Follow the Science " during the entire event.
Which I find amusing as hell because, what they really meant was, " Only follow the Science that we approve of and ignore everything else. "
To wit:
THE SCIENCE says, the vaccine development timeline usually takes around 5 - 10 years to go through all the trials, ensure its safety and d
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don't drag the rest of the World into your insanity along with you.
Well, that's the thing, they cannot mind their own business. They feel a moral imperative to come get into your shit and quiz you about your medical status and jockey politically to get everyone on a vaccine passport. Nevermind the fact that if the medicine worked that well in the first place and they had already taken it, there would be no reason to fear, would there? Well, it's "for the children damnit!" and how many times did kids get politicized as reasons for authoritarian policies? Then in the end tho
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So, everyone who was pro vaccine mandate ( and many even went full Nazi with deny those people healthcare, put em in quarantine camps and let them die ) loved to parrot the phrase " Follow the Science " during the entire event.
Which I find amusing as hell because, what they really meant was, " Only follow the Science that we approve of and ignore everything else. "
To wit:
THE SCIENCE says, the vaccine development timeline usually takes around 5 - 10 years to go through all the trials, ensure its safety and do the whole regulatory process to do as much as possible to ensure the safety of the product in question. But, those who pushed the Covid-19 vaccine just flat out ignored -THAT- science and elected to cut some corners in an effort to be seen as " doing something ".
You all want to line up and be a guinea pig, be my guest. But don't drag the rest of the World into your insanity along with you.
Why would Donald Trump do such a thing? https://trumpwhitehouse.archiv... [archives.gov]
Big Pharma stoke fears to sell product (Score:2)