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Medicine Biotech

Blood Test Could Help Detect Cancer Earlier In People With Nonspecific Symptoms (theguardian.com) 38

Slashdot reader eastlight_jim writes: Scientists from the University of Oxford have today published a study in Clinical Cancer Research which shows that they can use a technique called NMR (nuclear magnetic resonance) metabolomics analysis to identify patients with cancer. Specifically, they identify patients with cancer from within a population of generally unwell patients with non-specific symptoms like fatigue and weigh-loss — a traditionally hard-to-diagnose cohort.

The technique works because the NMR identifies small molecules called metabolites in the blood of patients and this information can then be used by machine learning to recognise patterns of metabolites specific to cancer, as well as identifying patients whose cancer has already spread.

The Guardian reports: If validated, the test could enable cancer patients to be identified earlier, when they are more likely to respond to treatment, and help flag up who could benefit from early access to drugs designed to tackle metastatic cancer.

The test can also tell if the disease has spread.

There is currently no clear route through which someone with nonspecific symptoms that could be cancer is referred for further investigation.... "The problem we've had in the past is that if they do have cancer, that cancer is growing all the time, and when they come back the cancers are often quite advanced," said Dr James Larkin, of the University of Oxford, who was involved in the research. Although it is difficult to know precisely how many individuals fall into this category, "it is likely to be tens of thousands of patients across the UK," Larkin said.

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Blood Test Could Help Detect Cancer Earlier In People With Nonspecific Symptoms

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  • by sizzlinkitty ( 1199479 ) on Saturday January 08, 2022 @11:13PM (#62156413)

    I'm a cancer survivor (neuroblastoma) and every year when I go for my check up, my insurance (Cigna) fights tooth and nail to avoid paying for any type of blood test, even though I have the highest plan offered by my employer (PPO). I expect others will run into the same issue in countries that don't provide free medical care.

    • I am also a cancer survivor. My local hospital did tests for a year and a half with no progress. I ended up traveling the world for a year and a half and the only ones with the balls to actually help were the Latvians. A year later I see a post of a medical office in Texas that made a "world first" breakthrough on magnets helping brain cancer. In this world, it's not first to do, it's first to publicize it.
      • I remember reading a Pop-Sci article (1980 ish) from one of the early researchers of the NMRI, and they were very hyped over the possibility of not only using the technology to identify cancers using NMRI spectroscopy, but being able to target specific chemical resonances in a treatment mode; which would damage cancer cells and only cancer cells. They were also using whole-body scans.

    • by antdude ( 79039 )

      I wonder if other countries have this problem like in Canada.

  • Maybe. Metabolemics is a bit of a buzz term IMO. Low SNR, machine learning based diagnostic assays, ugh. Plus non-specific: where is the cancer? How do you treat something where standard of care is chemo, radiotherapy, surgical resection, without anything big enough to show up on imaging? How do you validate this tool? Seems like a solution in search of a problem in part. Maybe it could lead to some interesting trials if it detects something normally incurable very early on like GBM and you carpetbomb with
    • Well, it tells you that there IS cancer somewhere, which justifies spending time and money finding it. When all you have is a patient who's tired, it's hard to justify much more than another round of blood tests looking for increasingly rare conditions..

      • Looking at it from a population health perspective, I remain skeptical that these tests will tell us more than say a PSA test, which while sensitive is not necessarily specific.
  • If you're at a loss of what your patient's problem may be then it seems like a great diagnostic tool, but more likely for for ruling out cancer (with 95% certainty) which lets them focus on other tests. However, if it is cancer and you are already experience weight-loss then the cancer has already grown significantly, so this is good news/bad news deal. I could be wrong but it's my understanding that the mass should be able to be spotted at this phase with other imaging technologies but those are up to in

  • NMR has been around a long time. There's a reason it's not used in clinical. THe instruments are expensive, 2 stories tall, require liquid nitrogen or more commonly liquid helium to cool a super-conducting magnet, not to mention they cost several million dollars a piece and have no real throughput to speak of. Then metabolites? How well does that correlate to cancer? Plenty of tech can look at metabolites today, cheaper and easier than NMR; this would have rolled out if we had a good correlation.

    Th

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