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Medicine Science

New Studies Find Evidence Of 'Superhuman' Immunity To COVID-19 In Some Individuals (npr.org) 149

Some scientists have called it "superhuman immunity" or "bulletproof." But immunologist Shane Crotty prefers "hybrid immunity." "Overall, hybrid immunity to SARS-CoV-2 appears to be impressively potent," Crotty wrote in commentary in Science back in June. From a report: No matter what you call it, this type of immunity offers much-needed good news in what seems like an endless array of bad news regarding COVID-19. Over the past several months, a series of studies has found that some people mount an extraordinarily powerful immune response against SARS-CoV-2, the coronavirus that causes the disease COVID-19. Their bodies produce very high levels of antibodies, but they also make antibodies with great flexibility -- likely capable of fighting off the coronavirus variants circulating in the world but also likely effective against variants that may emerge in the future.

"One could reasonably predict that these people will be quite well protected against most -- and perhaps all of -- the SARS-CoV-2 variants that we are likely to see in the foreseeable future," says Paul Bieniasz, a virologist at Rockefeller University who helped lead several of the studies. In a study published online last month, Bieniasz and his colleagues found antibodies in these individuals that can strongly neutralize the six variants of concern tested, including delta and beta, as well as several other viruses related to SARS-CoV-2, including one in bats, two in pangolins and the one that caused the first coronavirus pandemic, SARS-CoV-1. "This is being a bit more speculative, but I would also suspect that they would have some degree of protection against the SARS-like viruses that have yet to infect humans," Bieniasz says.

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New Studies Find Evidence Of 'Superhuman' Immunity To COVID-19 In Some Individuals

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  • Everyone - and I mean everyone- in our family had COVID. Our whole nuclear family. Aunts and uncles we hang out with. Grandparents. Close friends. Half his class.

    Despite repeated and prolonged exposure, he's never had so much as a sniffle.
    • by NFN_NLN ( 633283 ) on Tuesday September 07, 2021 @03:51PM (#61773141)

      Does he chew on fish tank cleaner? Or stick his finger in horse b-holes?

      I have some theories.

    • what's his blood type? I've read A is the most susceptible and I think O or B is supposed to be the least

      COVID bonds to the ACE2 protein and I've read somewhere that blood type has some effect on it

    • by Rhipf ( 525263 )

      All this really proves is that he didn't have symptomatic Covid. Most likely with everyone else around him having caught the virus he also caught it but just never developed symptoms. It could be that he is has "superhuman immunity" but without testing all we can conclude is that he never developed a symptomatic response.

      But don't let me stop you from calling him a superhuman if you want. 8^)

      • Covoid Gary?
      • by jabuzz ( 182671 )

        Yep unless he was having regular PCR tests that he didn't show symptoms tells us nothing. Roughly 1/3 of people don't show symptoms. Actual research in this area shows that once COVID-19 is in a household everyone is going to get it. Of course that research was undertaken before the vaccine, so what the situation is now I have no idea.

        • Not true. Covid hit my home twice. Once in January when my wife (RN at a nursing home) brought it home. With masking and social distancing as best as possible she only spread it to our breast feeding 5 month old. And not our two year old and myself

          In August the 5 month old is now a year old and the 2 year old brought it home from daycare because the daycare workers were unvaccinated. The toddler was even sharing a room with his 70 year old grandmother who was visiting. The grandmother mother and mysel

    • Sounds like your entire family is irresponsible.

    • What happens to him isn't important. What's important is that we harvest from him what we can right now. This body represents hundreds of millions... maybe billions of dollars worth of biotechnology. There are people out there, governments, corporations... who would kill for this chance. Will he survive the procedure? No, of course not. We need everything. Tissue, bone marrow, blood. The procedure's gonna basically strip him down to nothing.

      • by cstacy ( 534252 )

        What happens to him isn't important. What's important is that we harvest from him what we can right now.

        Will he survive the procedure?

        No, of course not. We need everything. Tissue, bone marrow, blood.

        I believe the phase you are looking for here is "precious bodily fluids."

        Well, sir, if the scientist is a really good man, I mean really sharp, why he can barrel that electron microscope along so low - well you just have to see it some time. A real small beam, like one nanometer thermionic emission gun, zig-zagging in, its jet exhaust frying chickens in the barnyard --- Hell, yes! He has one hell of a chance!

    • Re: (Score:1, Informative)

      Its because minors have practically ZERO chance of dying. only 400 people 0 to17 years old have died of COVID, fact. See CDC website: https://data.cdc.gov/NCHS/Prov... [cdc.gov]
    • Lots of people have no symptoms, but still very5 infected and can spread the disease. Did your son get tested? My wife got it, and I got tested about a week later, no trace. If I'd been infected without symptoms, it should have shown up at that point according to the medical specialist I spoke with.
  • Really just fueling Dunning-Kruger effect - oblig xkcd [xkcd.com].
  • by RightwingNutjob ( 1302813 ) on Tuesday September 07, 2021 @04:16PM (#61773213)

    Has been sacked.

    The people responsible for the sacking, with the publication of this story, have also been sacked.

    I'm an aerospace engineer, not a biologist, nor do I play one on TV, but I'll just float the obvious here:

    This pandemic is the first one of the "modern" era that has drawn the undivided attention of nearly every medical scientist in the world. Why exactly is that that we seem to think any discovery about the workings of the human immune system, which evolved over hundreds of millions of years, with respect to *this* virus are unique to this virus?

    • I think the issue is not so much that people thought the immune response would be unique, but rather the response would be "unknown" or "undefined" since the virus itself was an unknown and undefined quantity when this all broke out. IOW, we are still learning.

      • Which is a form of pre-scientific thinking.

        It began early on when at the same time reports were coming in of people recovering from infection--due to the action of their immune systems--speculation was rampant over whether reinfection was likely or whether vaccination was even possible.

        I'll say again: amid ample evidence of the effectiveness of the human immune system against sars cov 2, there were "questions" about the effectiveness of the human immune system against sars cov 2.
        And btw we know what it look

        • by PPH ( 736903 )

          And btw we know what it looks like when the human immune system is ineffective against a virus: AIDS.

          AIDS is due to a virus (or group of viruses) that specifically attack components of the human immune system. SARS-Cov-2 doesn't do that. Although SARS-Cov-2 is unique enough* to slip by the immune system, once that system is 'taught' by an mRNA vaccine, it seems to be pretty effective.

          *Possibly due to its source in a lab and it being significantly different from anything our immune systems have seen to date. rather than a plain old flu, which is usually a minor mutation from last year and something we are

        • I'll say again: amid ample evidence of the effectiveness of the human immune system against sars cov 2, there were "questions" about the effectiveness of the human immune system against sars cov 2

          Ample evidence of what, that the immune system does immune systemy-stuff, so all our questions are answered? Maybe you should stick to sheet metal, just saying.

      • It was somewhat unknown. We did learn very very early that it was closely related to SARS. And we already had vaccines for SARS. That's one of the reasons we got a vaccine so fast. (the other reason being that the mRNA technology was already here and had been tested and was no longer merely experimental)

        But other things are not clear, the same with any new virus where we have had zero years to study and investigate. Such as what are long term effects, how fast does it mutate, how effective are immune re

        • The choice to assume the worst plausible scenario (vaccines impossible, reinfection frequent, death rate many orders of magnitude higher than flu, only vaccine-induced immunity) over a more likely scenario (immunity works like any other virus, death rate at worst one order more than flu) was driven by panic.

          And the panic hasn't stopped.

          The media want their clicks, and the CDC wants its favorite butt cheek covered.

          Rationality and nuance are too much to ask for when panic dresses itself up as Science. Or God.

          • Best case scenario, it's still a terrible disease, still a very high death rate, with a very high transmission rate, and for quite some time at the start hospital wards were filling up beyond normal capacities, and recently the hospitalizations are indeed on the rise again with some locations not having room for new patients. It's not something to feel complacent about. So yet, it is not quite the level of panic, but all the fools who claimed it was a non-event are still fools. There's a middle ground wh

            • Okay so here's the thing: clogged up hospitals are the only only only justification for any kind of public health restrictions on economic activity. This got lost sometime around when masks became totems and a virus with a low-ish ifr for most people became the all-consuming focus and justification for every piece or nonsense imaginable.

              Close down universities? Elementary schools? Daycares? Why not!

              Clamp down on the food supply? Sure!

              Cancel elections and to fuck with any semblance of voter authentication wh

          • The choice to assume the worst plausible scenario (vaccines impossible, reinfection frequent, death rate many orders of magnitude higher than flu, only vaccine-induced immunity) over a more likely scenario (immunity works like any other virus, death rate at worst one order more than flu) was driven by panic.

            Straw man sad

          • * Vaccines impossible

            Who said that? What they did say was that a vaccine would take a long time to develop and produce - which was a reasonable prediction, but happily one that turned out wrong.

            reinfection frequent

            I don't think many said that either. I know I did say that this virus doesn't have any unusual clever way of evading the immune system (like HIV's subversion of the immune system, or flu viruses' extreme modularity), so reinfection didn't to me sound more plausible or common than reinfection with

            • Re: scary death rate.

              Okay I'll admit this is a legitimately subtle point so I'll try to explain myself without trolling too hard.

              Sars and mers were legit scary but also conspicuously slow in their spread. Ditto for ebola. And it's a general rule that things like incubation period, lethality, and contagiousness kind of tug against each other.

              For instance, a long incubation period implies slow replication or a fairly benign virus where lots of replicated virus doesn't cause that much trouble for the infected

              • by tragedy ( 27079 )

                Ok. Now explain away heart disease and cancer as not a big deal either.

                • Seeing as those are not infectious diseases, and are generally well-studied without any mass hysteria and panic attached to them, they can't really be "explained away" by appealing to Science 101 principles that got thrown out the window in said panic.

                  • by tragedy ( 27079 )

                    Since they're not infectious diseases, they're much harder to prevent than COVID-19. If there were a vaccine to significantly reduce the odds of either cancer or heart disease, it would be crazy not to take it. There actually is a clear example of that, actually. The HPV vaccine. HPV can cause cervical cancer. It's basically crazy for parents not to get it for their kids.

                    Regarding Science 101 principles that get thrown out of the window in the panic, I'm a little unclear what you mean. There is panic and m

                    • You're yelling back at Tucker Carlson, not responding to me.

                      Yes covid is killing people. Therefore it's a damn good idea for people pushing public health advice to a) recommend stuff that actually works and b) not piss away credibility by enforcing stuff that doesn't work or whose costs outweigh the benefit with religious fervor.

                      That's it. That's the overriding principle.

                      Pushing vaccines? Good and sound and probably effective.

                      Scaring the shit out of people about bare faces to the point where the more fragil

                    • by tragedy ( 27079 )

                      You're yelling back at Tucker Carlson, not responding to me.

                      Re-reading the thread, it still seems like I was responding to you.

                      Yes covid is killing people. Therefore it's a damn good idea for people pushing public health advice to a) recommend stuff that actually works and b) not piss away credibility by enforcing stuff that doesn't work or whose costs outweigh the benefit with religious fervor.

                      That's it. That's the overriding principle.

                      Which things are they recommending that doesn't actually work? Masking? That works. The problem is that they don't go hard enough on it and they also don't teach people to wear them properly. You see so many people with huge gaps around their nose and the sides along with people using masks with vents, etc., let alone the ones that don't wear them. Eye covering should be promoted as well. Social distancing? Once again, works, but people shou

                    • Repeat after me: widespread vaccine-derived (and infection-derived) immunity change everything.

                      It no longer matters that vaccinated people are catching and spearing covid among eachother. It doesn't contribute to the public health emergency because they aren't en masse incapacitated and aren't filling up hospitals.

                      The benefit of preventing spread among immune people pales in comparison to the benefits of preventing spread among unimmunized people. But the cost stays high.

                      As for small children in daycares...

                    • by tragedy ( 27079 )

                      Repeat after me: widespread vaccine-derived (and infection-derived) immunity change everything.

                      It no longer matters that vaccinated people are catching and spearing covid among eachother. It doesn't contribute to the public health emergency because they aren't en masse incapacitated and aren't filling up hospitals.

                      I'm not going to repeat after you. I think that might be a cultural difference there. Maybe in your subculture, that's how it works, people say things and then others just repeat after them by rote. I'm going to make my own informed decisions, thank you. I do appreciate though, that you do seem to be trying to reason your way through this. I think you're ignoring at least one important detail though. Spread of the virus is spread of the virus. Even if the vaccinated are better protected or asymptomatic, the

    • quite obviously, these folks figured out early on how much bleach to drink.

      Then, they engaged in a conspiracy to falsely label it as a stupid idea, figuring that when the rest of us died, they could
      [URLPP}

    • with respect to *this* virus are unique to this virus?

      Viruses aren't all the same. Duh.
      https://www.thelancet.com/jour... [thelancet.com]

      Obvious natural immunity straw man is obvious.

  • by LostMyBeaver ( 1226054 ) on Tuesday September 07, 2021 @04:22PM (#61773229)
    Some time ago, there was research published which suggested that that only 2% of drivers drove equally well while using their phones as when not.

    The result of this study is that an obscenely high percentage of people seemed to believe they were part of this 2%. And they all considered themselves excellent and more importantly safe drivers (I shared an office with one, he was my manager, I didn't contradict him).

    I figured it was more likely I was one of them. I'm a piss poor driver and I can't really see that using my phone would make me any more or less of a hazard to the other people on the road.

    I can already imagine that there will be a huge percentage of people who figure that since they haven't gotten covid (or didn't realize they did) they must be part of this miniscule percentage.
  • These super immune cases were first sick and then vaccinated. This might be reproduced by mixing the vaccines. ie both Pfizer and Moderna are mRNA vaccines but they may not create exactly the same spike protein. This might simulate being sick, exposed to one version of the spike protein and then being vaccinated exposing the immune system to a second, different spike protein. Waiting to hear about the mixing studies being done now.
  • by OneHundredAndTen ( 1523865 ) on Tuesday September 07, 2021 @04:54PM (#61773337)
    It is because of individuals similar to those, who had super-immunity to the 14th century plague, that the majority of us in Europe and America are here. The same could be done with SARS-CoV-2 - but I don't think many of us want to pay the price that the Europeans at the time did, whereby two thirds of them succumbed to the disease.
  • Did any of these superimmune folks visit Wuhan during the World Military Games. A bat virus encountering one of these super immune folks may have chnaged the virus into one which affects humans.
  • and put them in a food processor and liquefy them and inject a few CCs into everybody
  • Fact is, that ALL known earth bugs (bacteria, fungus, virus) have some sort of immune system against them, including in Humans. There are some humans (and their kids) that have ZERO immunity against say covid, but might have total immunity against HIV. And yes, there are ppl that will not catch HIV, UNLESS they were overwhelmed with a massive dose. The same is true of any disease.
    Note that this is about biological entities, not chemicals. For example, arsenic will kill all humans (at least as of this day).
  • This happened with HIV too [wikipedia.org]. If you read the separate article on delta-32 mutation, it's more common in Nordic countries and I remember reading about this "Scandinavian resistance" back when HIV was in the news more. Unfortunately they don't all have it, so I wouldn't be surprised if some people were like, "I don't have to worry, I'm Swedish" and ended up getting it. When I consider how much harder it is to get HIV (or how much easier it is to prevent, depending on how you look at things) I don't have a

    • i recall the story about HIV immunity, from a BBC radio programme. In that case, the immune individuals had some genetic variant that made them totally immune without any prior exposure to HIV. There was some speculation that the genetic variation may have come about as a result of exposure to and recovery from plague, in ancestors hundreds of years ago.

      I am not an immunologist, but I presume there is genetic variation between people, that affects their ability to resist Covid-19, regardless of prior exposu

  • It's a couple of percent who do not because of age, comorbidities or rare bad luck which are a concern. Not saying 140 million deaths out of 7 billion world population is a great prospect. But it's more like leprosy than black plague or HIV.

  • A podcast that I follow, by virologists and immunologists, had two of the authors (a husband and wife team) recently to discuss their finding.

    TWiV #796: The vary hungry spike with Paul and Theodora [microbe.tv]

    An interesting part: "we don't do T-cells". That is, they only study antibodies. Shows you how complex the immune system is, and how specialized research in it has become.

    One part I don't understand and would like to, but cannot find enough information on it: antibody affinity maturation. I assume that continued e

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