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Medicine

More Covid-19 Reinfections Found, But Researchers Urge Caution (statnews.com) 139

That Covid-19 reinfection in Hong Kong was followed by similar reports in Belgium and the Netherlands. It was announced today that a 27-year-old woman in Karnataka, India also tested positive for the disease a second time (though the government is still seeking confirmation), and now researchers in Nevada are also reporting a "likely" case of reinfection.

The health-news site Stat reports: What caught experts' attention about the case of the 25-year-old Reno man was not that he appears to have contracted SARS-CoV-2 (the name of the virus that causes Covid-19) a second time. Rather, it's that his second bout was more serious than his first. Immunologists had expected that if the immune response generated after an initial infection could not prevent a second case, then it should at least stave off more severe illness. That's what occurred with the first known reinfection case, in a 33-year-old Hong Kong man.

Still, despite what happened to the man in Nevada, researchers are stressing this is not a sky-is-falling situation or one that should result in firm conclusions. They always presumed people would become vulnerable to Covid-19 again some time after recovering from an initial case, based on how our immune systems respond to other respiratory viruses, including other coronaviruses. It's possible that these early cases of reinfection are outliers and have features that won't apply to the tens of millions of other people who have already shaken off Covid-19. "There are millions and millions of cases," said Michael Mina, an epidemiologist at Harvard's T.H. Chan School of Public Health. The real question that should get the most focus, Mina said, is, "What happens to most people...?"

Researchers are finding that, generally, people who get Covid-19 develop a healthy immune response replete with both antibodies (molecules that can block pathogens from infecting cells) and T cells (which help wipe out the virus). This is what happens after other viral infections.

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More Covid-19 Reinfections Found, But Researchers Urge Caution

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  • by rsilvergun ( 571051 ) on Sunday September 06, 2020 @12:42PM (#60479532)
    won't take a vaccine. So if the immune response is short lived then it's going to be really hard to put out the virus. Double so because when a vaccine drops there will be a campaign to discourage mask wearing from that 30-40% because they're desperate to get back to "normal".

    I personally know somebody who thinks the CDC reported death toll is a hoax. They're not even pushing that nonsense about "only 6% died of COVID" (i.e. doesn't understand what a comorbidity is or that 11,000 healthy people died of the disease), they just plain think the death toll numbers are fake...

    Unless we get some top down changes in the coming months then we won't be able to get this pandemic under control.
    • won't take a vaccine. So if the immune response is short lived then it's going to be really hard to put out the virus. Double so because when a vaccine drops there will be a campaign to discourage mask wearing from that 30-40% because they're desperate to get back to "normal".

      I'm waiting for some idiots to start doing what they were doing with chicken pox and having "COVID parties" to deliberately infect their kids in lieu of a vaccine because the vaccine is "unnatural."

      • by rsilvergun ( 571051 ) on Sunday September 06, 2020 @01:12PM (#60479618)
        The media ran stories about it being young people, which was quickly debunked, but there have been several cases of parents doing just that. Here's the right wing British paper "The Sun" discussing it [the-sun.com] with their "expert".
      • by sjames ( 1099 )

        They're already doing COVID parties even without a vaccine. At least when parents did it with chicken pox, it actually worked and made sense (since chicken pox is a much milder disease in childhood and was known to provide life-long immunity).

      • by tepples ( 727027 ) <.tepples. .at. .gmail.com.> on Sunday September 06, 2020 @04:38PM (#60480164) Homepage Journal

        I'm waiting for some idiots to start doing what they were doing with chicken pox and having "COVID parties" to deliberately infect their kids

        No need to wait. Follow citations in "Coronavirus party" on Wikipedia [wikipedia.org] to see where it's already been happening.

    • by nospam007 ( 722110 ) * on Sunday September 06, 2020 @12:56PM (#60479580)

      "won't take a vaccine. So if the immune response is short lived then it's going to be really hard to put out the virus."

      Why? The Antivaxxers get it twice a year, after 10 years, no more Antivaxxers.
      Think of it as evolution in action.

      • Not good enough. (Score:5, Insightful)

        by Brain-Fu ( 1274756 ) on Sunday September 06, 2020 @01:21PM (#60479640) Homepage Journal

        When anti-vaxxers refuse to take vaccines, they put others at risk, including those who cannot take the vaccine for medical reasons, and those who do take the vaccine (since the vaccine does not produce total immunity).

        So, their stupidity harms people other than themselves, which is why we need to at least try to educate them out of their stupid ideas. Simply waiting for them to die off will take too long and allow too much harm to be caused.

        • "So, their stupidity harms people other than themselves, which is why we need to at least try to educate them out of their stupid ideas. "

          Good luck with that, they all suffer from the Dunning-Kruger Effect and will know everything better than you.

          https://en.wikipedia.org/wiki/... [wikipedia.org]

        • That is why most countries have mandatory vaxxing for the stuff that matters.

          And COVID-19 will probably be added to that list.

      • which if you're not bad at math you'll know that is an _insanely_ high rate for a disease. But, well, Americans are bad at math.

        The way it was explained to me (by Beau Of the Fifth Column) is this: If you walked into a grocery store where 1 out of every 180 customer got shot and killed, would you go to that store?

        Now, the virus does have long term side effects, so it's very likely we'll see a sea change in America (and I don't know any "nice" way to say this because it's all kinds of fucked up) as o
        • It kills about .6 - 1% of the time which if you're not bad at math you'll know that is an _insanely_ high rate for a disease. But, well, Americans are bad at math.

          Huh? The COVID CFR in the US is 3%. What's your math that says it's 0.6 - 1%?

          • not the ones from the US. I'm intentionally understating the effect in America because if I don't a bunch of Alt-right and/or Russian trolls will pile on to say "rsilvergun is lying!". I didn't need the higher rate to prove my point anyway.

            Yes, these are the kinds of rhetorical techniques you need to win. We're basically at war with these jokers. /. is a solid battle ground because you've got a ton of centrist techies who want to vote Republican because they don't like being told what to do but they're
            • I'm using global numbers not the ones from the US.

              Huh? The global COVID CFR is 3.3%. What's your math that says it's 0.6 - 1%?

              I'm intentionally understating the effect in America because if I don't a bunch of Alt-right and/or Russian trolls will pile on to say "rsilvergun is lying!".

              So deliberately posting misinformation is going to stop trolls from saying "rsilvergun is lying"? How the fuck does that work? Common sense says posting wildly inaccurate numbers does just the opposite. And when you follow it up with "Americans are bad at math"...well you just look foolish.

              Yes, these are the kinds of rhetorical techniques you need to win. We're basically at war with these jokers. /. is a solid battle ground because you've got a ton of centrist techies who want to vote Republican because they don't like being told what to do but they're smart enough to know better.

              Slashdot is full of knowledgeable people that know math. If you think you're going to win anybody over on this site by posting faulty numbers

              • by q_e_t ( 5104099 )
                The 0.6 to 1% statistic tries to take into account under reporting of cases.
                • And just how do you know that? When asked for an explanation, rsilvergun made no mention of taking under-reporting of cases into account. And 0.6 - 1% doesn't correspond to any data on under-reporting that I'm aware of. Maybe you can point me to a source that says there are 3.3 to 5.5 times more infected than reported.

                  Look, rsilvergun has a long history of posting wildly inaccurate stats on this site, and he has continued to repeat the same falsehoods even after being corrected. I call that lying. An

                  • by q_e_t ( 5104099 )

                    And just how do you know that?

                    Reading things.

                    • Reading things? LOL, like what? rsilvergun's mind? You can't possibly know that rsilvergun was trying to take into account under reporting of cases when he posted his numbers. And of course there's his response, which makes no mention that he was trying to do what you say. Of all these "things" you say you've read, apparently you missed reading his reply.

                      Tell you what, if you've actually read something that says the true number of infected is 3.3 to 5.5 times more than reported, why don't you post a

                    • by q_e_t ( 5104099 )

                      Reading things? LOL, like what? rsilvergun's mind?

                      No, reports by places like the London School of Hygiene and Tropical Medicine

                  • by q_e_t ( 5104099 )

                    I don't understand why you would want to make excuses for this guy.

                    I didn't. I posted a fact.

                    • by q_e_t ( 5104099 )
                      Actually the current estimate is 0.4 to 0.7%, so rsilvergun is a bit out.
                    • I didn't. I posted a fact.

                      You're kidding, right? No, you didn't post a fact. You posted a theory. A theory about what completely bullshit numbers were supposed to represent. A theory that attempts to legitimize said bullshit numbers. A theory that has absolutely no evidence to support it, and has rather conclusive evidence against it.

                      Actually the current estimate is 0.4 to 0.7%, so rsilvergun is a bit out.

                      A bit out? If you go by the CDC estimate of under-reporting (6-24X), it's 0.125 to 0.5%. rsilvergun not only isn't the ballpark, he isn't even in the ballpark's parking lot.

                      Your numbers indicate

                    • by q_e_t ( 5104099 )

                      You're kidding, right? No, you didn't post a fact.

                      That the current estimate is 0.4 to 0.7% is a fact. The fact may be an estimate (which is not a theory). If you are going to debate with people at least try to get some grip on terminology.

                      A bit out? If you go by the CDC estimate of under-reporting (6-24X), it's 0.125 to 0.5%. rsilvergun not only isn't the ballpark, he isn't even in the ballpark's parking lot.

                      Your numbers indicate a 4.2X - 7.5X number of actual infections. Where did you get them?

                      London School of Hygiene and Tropical Medicine

                    • by q_e_t ( 5104099 )
                      To make it easy for you: https://www.lshtm.ac.uk/resear... [lshtm.ac.uk]
                    • To make it easy for you: https://www.lshtm.ac.uk/resear... [lshtm.ac.uk]

                      There is NOTHING on that page that says cases are under-reported by 4.2X - 7.5X. I did a quick search of that site and found a reference [lshtm.ac.uk] to this paper, [nih.gov] which says actual cases are far far higher than your 4.2X - 7.5X numbers:

                      Our results suggest that by the time a single death occurs, hundreds to thousands of cases are likely to be present in that population.

                      If you're going to "make it easy" for me, you should provide a link to an actual document that supports your claim, preferably with a relevant quote f

                    • That the current estimate is 0.4 to 0.7% is a fact.

                      There may be an estimate claiming those numbers, but there are many [jamanetwork.com] many [nih.gov] more that say otherwise. But somehow your estimate is a "fact" and the others are not? LOL.

                      Even if your estimate is true, so what? rsilvergun didn't post those numbers, and you didn't post those numbers until after you said "I posted a fact." When you said that, you were referring to your first post on this matter, which was "The 0.6 to 1% statistic tries to take into account under reporting of cases."

                      Your statement is quite

                    • ...which are estimated to be 40% or more of COVID cases.

                      I don't really care if your 0.4 to 0.7% numbers are accurate or not. They don't come close to rsilvergun's 0.6 to 1% numbers which are 40 to 50% off. You can flail around all you want and try to say he was referring to actual data, but he wasn't. He pulled those numbers straight out of his ass, and said as much in his reply.

                    • by q_e_t ( 5104099 )

                      But somehow your estimate is a "fact" and the others are not?

                      It's not my estimate. It is a fact that it is one of the available, well researched estimates.

                      Even if your estimate is true, so what? rsilvergun didn't post those numbers, and you didn't post those numbers until after you said "I posted a fact." When you said that, you were referring to your first post on this matter, which was "The 0.6 to 1% statistic tries to take into account under reporting of cases."

                      The figure was close to the 0.4 to 0.7% so I didn't feel the need to go and post detailed references. I have now done so.

                      Your statement is quite clearly a theory, and a poor one at that.

                      How do you know it's poor? Could you post a link to your original research?

                      All I did was ask where those numbers came from. Your transparent attempt to put words in my mouth suggests that *you* are the one who needs to work on their debating skills.

                      You should understand the difference between a theory and an estimate. It's pretty fundamental stuff in science.

                    • by q_e_t ( 5104099 )

                      There may be an estimate claiming those numbers, but there are many.

                      So I looked at the second of your links, and the estimates of underreporting it shows for various countries are similar to those from the LSHTM, so I am not sure what point you are trying to make.

                    • by q_e_t ( 5104099 )

                      I don't really care if your 0.4 to 0.7% numbers are accurate or not. They don't come close to rsilvergun's 0.6 to 1% numbers which are 40 to 50% off.

                      0.4 to 0.7% overlaps with 0.6 to 1%.

                    • It's not my estimate. It is a fact that it is one of the available, well researched estimates.

                      You have yet to point to a source that supports your numbers. If this estimate is so available, why haven't you posted it?

                      The figure was close to the 0.4 to 0.7% so I didn't feel the need to go and post detailed references.

                      Sure, if by "close" you mean "off by 50%"

                      I have now done so.

                      Really? Where? You've posted two links, one that makes no mention of under-reported cases, and another that doesn't take into account asymptomatic cases and says there's a world-wide under-reporting of cases by 1.4 - 17.8X

                      Even if rsilvergun posted your exact numbers, I DON'TCARE. The notion that he was referring to under-reporting of cases is

                    • So I looked at the second of your links, and the estimates of underreporting it shows for various countries are similar to those from the LSHTM, so I am not sure what point you are trying to make.

                      Can you read? I guess not. Here, let me help you:

                      Estimate of the Case Ascertainment Ratio (CAR)
                      We show that the unaccounted cases exceed the reported by 10 to 20 fold

                      Does 10X - 20X sound like 4.2X - 7.5X to you? At this point, I wouldn't be surprised if it does.

                    • by q_e_t ( 5104099 )

                      Can you read?

                      I read the paper. It shows (with error bars) a variety of ratios for different countries. For some (e.g. Brazil) it is in the 10x to 20x range, and for others, it is not and is, indeed, in the 4.2 to 7.5x range, although quite what that has to do with IFRs directly I am not sure since CFRs vary by country as well. If you compare against the LSHTM paper the figures there are broadly in agreement for the countries represented, or at least the sample I compared as I didn't look at every single one.

                      I guess not.

                      I read the w

                    • by q_e_t ( 5104099 )

                      You have yet to point to a source that supports your numbers. If this estimate is so available, why haven't you posted it?

                      Sorry, I thought I'd posted the links to the LSHTM website, and so some of my comments about the similarity between your figures on under reporting may not have made sense, not the 0.4-0.7% figure. Apologies if I failed to hit submit on that post and I will dig out the links again.

                      Sure, if by "close" you mean "off by 50%"

                      They are figures with error bars. In some instances it is valid to compare the mean points with the presumption of a Gaussian distribution, but it is not a given. What you should actually do is determine the actual shape of the di

                    • So in the entire section of the paper titled "Estimate of the Case Ascertainment Ratio (CAR)" there is *one* range of figures reported by the researchers (10X - 20X) and they make no mention of anything close to 4.2X - 7.5X anywhere in the entire text of their paper. Since according to you, the researchers data actually shows something close to a range of 4.2X - 7.5X, I guess those silly scientists forgot to mention it.

                      Sure man, whatever you say. Sounds plausible. Maybe you should contact them so they c

                    • Sorry, I thought I'd posted the links to the LSHTM website, and so some of my comments about the similarity between your figures on under reporting may not have made sense, not the 0.4-0.7% figure. Apologies if I failed to hit submit on that post and I will dig out the links again.

                      They are figures with error bars. In some instances it is valid to compare the mean points with the presumption of a Gaussian distribution, but it is not a given. What you should actually do is determine the actual shape of the distribution and the area of overlap. Since the ranges are reasonably tight and overlap it's not inaccurate to say they they are close. If the ranges were 1-50 and 49-99 then it would not be reasonable to call them close, but that isn't the case here. Without additional information we don't know if the 0.4-0.7% range is weighted to the upper or not, or the 0.6-1% figure to the lower. The probability that the real figure is the same may be very high. I'd suggest looking at sampling theory or other areas of statistics or metrology for background understanding.

                      BLAH BLAH BLAH. One more time: Even if rsilvergun posted your exact numbers, I. DON'T. CARE. The notion that he was referring to under-reporting of cases is shit. His own reply says so. It doesn't matter if his numbers "overlap" with what you think are the correct numbers. He wasn't referring to under-reporting, period. The only way you can say he was referring to under-reporting is if *you* are a *mind-reader* and his reply to me was a *lie*. Can you prove both those things?

                      I never said your estimate was a theory.

                      I have never said it was my estimate. Continuously claiming I said things that I didn't just makes you look foolish.

                      Your little semantics gam

                    • by q_e_t ( 5104099 )

                      Sorry, I thought I'd posted the links to the LSHTM website, and so some of my comments about the similarity between your figures on under reporting may not have made sense, not the 0.4-0.7% figure. Apologies if I failed to hit submit on that post and I will dig out the links again.

                      They are figures with error bars. In some instances it is valid to compare the mean points with the presumption of a Gaussian distribution, but it is not a given. What you should actually do is determine the actual shape of the distribution and the area of overlap. Since the ranges are reasonably tight and overlap it's not inaccurate to say they they are close. If the ranges were 1-50 and 49-99 then it would not be reasonable to call them close, but that isn't the case here. Without additional information we don't know if the 0.4-0.7% range is weighted to the upper or not, or the 0.6-1% figure to the lower. The probability that the real figure is the same may be very high. I'd suggest looking at sampling theory or other areas of statistics or metrology for background understanding.

                      BLAH BLAH BLAH. One more time: Even if rsilvergun posted your exact numbers, I. DON'T. CARE. The notion that he was referring to under-reporting of cases is shit. His own reply says so. It doesn't matter if his numbers "overlap" with what you think are the correct numbers. He wasn't referring to under-reporting, period. The only way you can say he was referring to under-reporting is if *you* are a *mind-reader* and his reply to me was a *lie*. Can you prove both those things?

                      I never said your estimate was a theory.

                      I have never said it was my estimate. Continuously claiming I said things that I didn't just makes you look foolish.

                      Your little semantics games aside, I've got some news for you. As of now, it is YOUR estimate, since you have provided zero links/quotes from the LSHTM that says it's THEIR estimate. Instead of simply posting your source, you decided to type out a sermon on error bars, distributions, sampling theory, statistics and metrology. Nice work.

                      Thing is, I've never questioned the validity of YOUR numbers. All I did was point out that there are estimates out there that suggest a far higher number of actual vs reported infections. As I've said several times now, Even if rsilvergun posted your exact numbers, I. DON'T. CARE. Your claim that he was referring to under-reporting of cases is bullshit, and his reply to my inquiry on where his numbers came from proves it.

                      You said:

                      You're kidding, right? No, you didn't post a fact. You posted a theory.

                      I've explained to you multiple times now that I was not referring to your 0.4 - 0.7 figures as a theory, yet you keep repeating this ridiculous claim over and over and over. Here, let me help you once more: YOUR FIGURES ARE FACTUAL!!! However, your claim that rsilvergun was referring to under-reported cases when he posted his shit numbers is utterly false.

                      There. I validated your numbers, without you providing a shred of evidence for them, and didn't use the word "theory" at all. Feel better now?

                      I indicated the source of the estimate I provided. I realise it was a different message board that I posted the links. I will post them here when I retrieve them and grab direct quotes. However, your bizarre level anger confuses me.

                    • You're confused all right, and you've been confused since your very first post. I'm angry? LOL, people like you are incapable of making me angry. At most, you're an annoyance. Let me give you some examples of why you're annoying:

                      You commented "I posted a fact", and the only things you had posted at that point were "The 0.6 to 1% statistic tries to take into account under reporting of cases." and "Reading things." You then post "Actually the current estimate is 0.4 to 0.7%", which I didn't reply to.

      • The only way you weed them out of the gene pool would be by identifying them and quarantining them 100% before they could spread it around, the problem being that apparently one can be asymptomatic for weeks but still be contagious. You'd have to identify someone as an 'anti-vaxxer' and in essence arrest them and put them in an internment camp or something to keep them away from the general population. Imagine uproar there'd be over that. They'd all be turned into martyrs. You really don't want that to happ
      • Re: (Score:2, Flamebait)

        Comment removed based on user account deletion
      • The Antivaxxers get it twice a year, after 10 years, no more Antivaxxers.

        Except that they teach others to be antivaxers, so it doesn't stop.

        Every generation is born ignorant and has to learn about this stuff. That means:
          - Some of them learn bad things.
          - We're never more than a generation or two away from a possible reemergence (usually under a different name and with slight changes) of ANY disastrous ideology.

    • This relapse thing seems very rare. Also there is a false positive rate for some Covid tests. If this person was only tested once before, what if that test was a false positive? Statistically it could happen -- there are millions of covid positive people .. if the false postive rate was even 1 in 1000 there's bound to be a few of that 1000 who test positive or actual catch it a "second time". Another explanation is that the original infection failed to clear fully, or the person's immune system is not norma

      • Also there is a false positive rate for some Covid tests.

        There is also a false negative rate. The two balance each other out.

        • by tepples ( 727027 )

          This sort of balancing of false alarms and missed cases applies to a population, not to an individual. The article is about individuals who appear to get reinfected.

      • the genes. e.g. if they're reporting on it then it's because they're 100% sure it wasn't a mistest.

        Again, everybody knows you can get it again, the question is how often does that happen and is the second infection worse? Also given that there are long term health consequences to getting sick how much risk is that going to mean?

        The point is we don't know, and so we should be very, very cautious. Trouble being that there's a _lot_ of people who don't want other's to do that, because it's bad for them
      • Yeah, they've started doing DNA sequencing and proving that at least some people are getting a second strain and others are getting the same strain. So, the current probability is that there's a bell curve of immunity and the near end is 4 months. Which means that idiots hoping for a herd immunity are never going to solve anything, as opposed to solving things after millions of deaths.

    • I think you're getting ahead of yourself. We don't even know if an effective vaccine exists, let alone how long its effects will last. Maybe recovery from Covid-19 is only a transient state, but that's only one of many bad cases we still can't rule out.

      Having said that, it wasn't a terrible FP, though not well focused on the story. Were you in a hurry to FP before the AC trolls? [Hence my change of Subject, even though I'm starting with your focus.]

      In terms of reinfections, I think the primary link to Ameri

      • Re: (Score:3, Insightful)

        Anti-vaxxers be anti-vaxxers; when someone doesn't even 'believe' in science being real in the first place, how do you 'explain' or 'convince' them that something created by 'science' is going to be good for them at all, and not some trick that's going to turn them into obedient robots, or give them a disease, or kill them outright, or turn their kids into autists?
        I suspect that much of the problem here is that you have people who can't understand science and technology to begin with, don't have the intell
        • Even smart people do dumb things at times. I'm certain I have some mistaken beliefs, some of which I probably can't be reasoned with about.

          The problem with anti-vaxxers isn't necessarily raw intelligence, or that they *can't* understand things. I'm sure they could have it explained to them if they were willing to listen.

          It's that they reject the information, not that they can't understand it.

          It's a different sort of mental trap that they are in than just not having the intelligence.

          Here are some examples

      • Imagine:
        - a little bit higher amount of hard cases
        - a little bit higher amount of death
        - a little bit higher rate of infection rate

        In a country with a:
        - dysfunctional government
        - dysfunctional medical system
        - dysfunctional health care system

        We can be lucky that this virus is so relatively harmless.

        • by shanen ( 462549 )

          Basically agree. The main one you left off that I was considering was a longer period of low-symptom contagiousness.

          • by Guppy ( 12314 )

            The main one you left off that I was considering was a longer period of low-symptom contagiousness.

            Another place we got extremely lucky, is the relatively lower mortality among infants and children.

            Increased morbidity and mortality among the very young is actually quite a common trait for respiratory virus epidemics. The number of life-years lost to COVID could easily have been much higher, had it not been for this atypical characteristic.

    • Frankly, all this 'anti-vaxx' bullshit makes me want to punch walls, solid brick walls, with my bare fists, those people are so fucking stupid.
      Part of me says call it 'evolution in action', but the other half of that equation is illegal: we aren't allowed to murder these idiots for being too gullible (falling for a troll-meme like 'vaccines are dangerous') or exile them from our society (drop them off in a life raft in international waters to fend for themselves) and frankly we'd be poor human beings even
      • by dryeo ( 100693 )

        Then of course there's the whole 'anti-science-in-general' movement, which I believe has organized religion behind it.

        It's a byproduct of capitalism, though other systems have a similar problem. Big tobacco started it with battling the science that said smoking killed. Then the same was done about climate change, starting with attacking nuclear energy, and then the rest of the science behind it. As someone once said, "if your paycheck depends on not being convinced of the science, you won't be convinced". I'm probably paraphrasing.
        It has also been compounded for political and religious ends.

  • Immune overresponse (Score:5, Informative)

    by Randseed ( 132501 ) on Sunday September 06, 2020 @12:52PM (#60479560)
    Part of this appears to be an immune overresponse. In other words, a person gets the infection and their immune system goes bat shit crazy producing a lot of excess inflammation and cytokine storms, and the like. Infections of this virus have been associated with Kawasaki disease in children, and various other syndromes in adults including lingering myocarditis and hypercoagulability syndromes. I haven't really looked into it, but I wonder if why it seems more minor in children is that the standard response to respiratory illness and lung inflammation in children is to immediately blast them with steroids. I do remember reading something a while back suggesting a better outcome on patients that were hit with dexamethasone before they even need a vent. Another thing done on children before invasive ventilation is typically a high flow nasal cannula which is basically nasal CPAP.

    There's just so much FUD out there about this virus that it's hard for even doctors to get good information because the treatment protocols are different in different areas and they're evolving so quickly.

    • I can't find the story about it right now, but you're not wrong, not at all, a study they've done shows what you're talking about, that perhaps the majority of the damage done when infected comes from the bodys' own immune system going into overdrive and flooding the body with substances that just wreck you. I think the same study also pointed to a particular type of treatment that would potentially be very effective.
  • by quonset ( 4839537 ) on Sunday September 06, 2020 @12:54PM (#60479570)

    people who get Covid-19 develop a healthy immune response replete with both antibodies (molecules that can block pathogens from infecting cells) and T cells (which help wipe out the virus).

    I'm sure those college athletes who caught covid-19 are happy to know they have antibodies and T cells to go along with their heart inflammation.

    "What we have seen is when people have been studied with cardiac MRI scans — symptomatic and asymptomatic COVID infections — is a level of inflammation in cardiac muscle that just is alarming," he said.

    • Re: (Score:3, Informative)

      by Anonymous Coward

      That story about college athletes having heart inflammation is a prime example of fake news. They've since published corrections [zerohedge.com], but nobody ever bothers going back to read those...

      • That story about college athletes having heart inflammation is a prime example of fake news. They've since published corrections [zerohedge.com], but nobody ever bothers going back to read those...

        Someone mod this up

  • When they found the first instance in Hong Kong, it was funny how many people jumped to the conclusion that because the one case was less severe the second time that it would always be less severe the second time. This is how we get climate change deniers and Trump supporters.
    • At the same time you have biden saying the vaccine will not be safe and that he is not even sure there is a vaccine available.
      trump pushing that a vaccine might be available in November and that it readily available for everyone is not where the science deniers are.
  • by renegade600 ( 204461 ) on Sunday September 06, 2020 @01:22PM (#60479644)

    every time I hear the vaccine will need more than one shot or the antibodies goes away after a period of time, it reminds me of an animated superman movie. It is the one where Lex Luthor's team discovered the cure for cancer but Lex told them to redo it and fix it to require a lifetime of shots for more profit.

    Are we being setup for future profits with all these types of articles?

    • If you would not live in a 3rd world country, a livelong requirements for a simple vaccine would not be an issue at all.

    • Not really, there is a well known "the governmetn is giving you a one time payment and taking your IP" endgame for the successful vaccine manufacturer.

  • As expected (Score:5, Interesting)

    by BenJeremy ( 181303 ) on Sunday September 06, 2020 @01:40PM (#60479694)

    I recall, when this pandemic was first described as a coronavirus, scientists spelled out the expectations:

    1) No lasting immunity, either because our bodies would not maintain antibodies, or because of mutations. In this respect, it was compared to rhinoviruses.
    2) While considerable research had been done, nobody had successfully created a vaccine for coronaviruses
    3) Anecdotal stories emerged early on supporting re-infection. The whistle-blower doctor in China supposedly fought off two bouts of infection, before succumbing to it on the third.
    4) There are reasons why we do not keep producing antibodies that prevent infection through ACE2 receptors. this receptor has a purpose, and inhibiting its use for long periods of time is probably inadvisable.
    5) We are starting to see signs that once it initially infects our bodies through the ACE2 receptors, it starts exploiting other ways to invade our cells and replicate.

    The best case scenario is that we will likely have a vaccine, and require a booster, until COVID-19 is pretty much gone, and break it out when there are flareups. There will be no lasting immunity to this disease.

    • Re: (Score:3, Interesting)

      Your point #1 about no lasting immunity because of mutations might be the most important future problem. Apparently mutations have been found in SARS-CoV-2 virus. Not sure if the mutants produced more or less severe problems or are more or less contagious. And, would a new vaccine need to be developed for each mutant, much like is the case with flu? It's early times.
    • by rsilvergun ( 571051 ) on Sunday September 06, 2020 @02:28PM (#60479844)
      for H1N1 as well as general vaccines for Coronaviruses back in the mid 2000s. Then the H1N1 virus went away on it's own and we immediately stopped funding research because vaccines aren't profitable without a raging pandemic.

      It's extremely likely this wouldn't be happening if we had a health care system that wasn't driven by the profit motive.
  • I'd think that if you expose yourself thoroughly enough to just about any pathogen you could get it a second time, regardless of having antibodies for it in your system or not. 'Having an immunity' to something doesn't necessarily make you bulletproof to it, it just means you immune system theoretically can handle it if it tries to get you.
    Then there's also the fact that some people just have weak immune systems to start with, for one reason or another.
    So I don't find it surprising that some people would
  • I'm curious about the Slashdotters' opinions: Could a lockdown theoretically resolve this pandemic if sufficiently long/hard enough, or will there "always" be virus particles somewhere?
    • by davidwr ( 791652 )

      Could a lockdown theoretically resolve this pandemic if sufficiently long/hard enough, or will there "always" be virus particles somewhere?

      Is it possible? Yes. Is it practical? Probably not.

      New Zealand and some small island nations in the Pacific are managing, but with difficulty.

      Basically, if we could divide the world up into "quarantine zones" with minimal human interaction between them, large parts of the world could be declared COVID-19-free within a few years. I don't see that happening, it's just too heavy of a burden on most countries and all but impossible for some.

      Anyhow, that would likely take longer than a worldwide vaccination

    • We know it affects animals because that is where they say it came from. So the wild cat population gets this then they spread it to domestic cats then to you. So you would need to eradicate the virus from wild animals, or quaranteen people from wild animals.
  • It's very rare, but some people can get chicken pox more than once in their lives. Granted, that is probably a "re-activation" like shingles rather than a true "re-infection."

    Anecdotal evidence of occasional COVID-19 re-infections early after recovery doesn't concern me. What is important is knowing the probability of re-infection at various times after recovery - zero to 3 months, 3-6 months, 6-9 months, 9-12 months, etc. Is the immunity after 3 months is 99.999% that's great, if it's 99% that's still g

  • well duh if they just stopped testing like President Gropenfurher says then we wouldn't have all these darn cases!!1!

    And vaccines?? It just so happens that the word "vaccine" starts with a "V", and do you know who doesn't have a "V" in their name?

    BILL GATES, thats who!! You think thats a concidance, mr smarty science guy?

    And where was Barack Obama on 9-11? Why wasn't he in the Oval Office? Someone should look very strongly at that!

Some people manage by the book, even though they don't know who wrote the book or even what book.

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