70 Coronavirus Vaccines in Development, 3 Candidates Already Undergoing Human Trials (theprint.in) 121
There are 70 coronavirus vaccines in development globally, with three candidates already being tested in human trials, according to the World Health Organization, as drugmakers race to find a cure for the deadly pathogen. From a report: The furthest along in the clinical process is an experimental vaccine developed by Hong Kong-listed CanSino Biologics and the Beijing Institute of Biotechnology, which is in phase 2. The other two being tested in humans are treatments developed separately by U.S. drugmakers Moderna and Inovio Pharmaceuticals, according to a WHO document. Progress is occurring at unprecedented speed in developing vaccines as the infectious pathogen looks unlikely to be stamped out through containment measures alone. The drug industry is hoping to compress the time it takes to get a vaccine to market -- usually about 10 to 15 years -- to within the next year.
This is always how the zombie apocalypse starts (Score:2)
I’m guessing there were reasons that it took so long.
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Errrrrrrrr....what vaccine takes 10-15 years to go to market? H1N1 took 4 months. You guys are such shitheads.
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Slashdot is fine for arguing over Java vs. .Net, C++ vs. Rust, significant whitespace vs. braces, GPL vs. BSD, but when it comes to biology? LOL; ideas come from Video Game and Netflix Drama plots.
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Well, it's reasonable to argue over whether a vaccine for a new strain of the flu counts as a new vaccine. I guess it is.
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More like a service pack.
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Progress: A story you can send to your friends (Score:3)
70 Coronavirus vaccines in development,
3 candidates already undergoing human trials.
70 Coronavirus vaccines in development, 3 candidates already undergoing human trials: WHO [theprint.in] (Apr. 13, 2020)
"Development of vaccines is happening at an unprecedented speed as the infectious pathogen looks unlikely to be stamped out through containment measures alone."
WHO, World Health Organization, PDF file: DRAFT landscape of COVID-19 candidate vaccines --11 April 2020 [who.int]
Another story, Bloomberg.com:
WHO Says 70 Va [bloomberg.com]
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At least we'll be living zombies ... or is there such a thing?
(ApocalTip: I hear bacon bits make brains taste better.)
Toxo, meningitis, or CJD (Score:2)
At least we'll be living zombies ... or is there such a thing?
Yes.
Though ghouls (undead people) are probably the best-known class of zombie in the zombie apocalypse genre, another major class is people infected with something like toxoplasmosis, rhinocerebral mucormycosis, meningococcal disease, or CJD.
Further reading: Articles by Cyriaque Lamar [cracked.com], T. E. Sloth and David Wong [cracked.com], and Alex Kendziorski [cracked.com].
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Well, we *hope* rightly. There have been a few instances where mistakes were made about that. So far nothing really major, unless you consider thalidomide major.
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It only did a little bit of arm.
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Many of these things were serious to you if they affected you, but they didn't affect that many people, so most people didn't consider it serious. Thalidomide affected more people than, say, the Dengue fever vaccine problem.
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OK, but I'm tired of this game. Zombie Apocalypse sounds like a lot more fun than sitting at home and washing any boxes that are delivered.
We only need one! (Score:1)
Far better would it be for everyone to work together instead of competing at this point.
Not a matter of competing (Score:5, Insightful)
We only need one working one. We won't know which of the 70 works at all, works the most effectively, doesn't have showstopper side effects, etc until the trials are over.
Better to have 70 trials at once than go one-at-a-time.
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I assure you, the people who develop these and the agencies that fund and regulate them are smart enough to figure out these things :-).
They are not politicians.
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But don't underestimate the ability of politicians to stick their fingers into pies.
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Especially fur pies.
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Exactly. So experts definitely understand that there is need for several parallel efforts.
In any case, it was "We only need one!" post that was silly.
My post came off as if I was disagreeing with OP, when I intended it more along the lines of: we don't have any advice to offer to the experts, they are quite reasonable.
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You would be surprised how dumb funding agencies can be. They are effectively run by politicians.
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Medical research funding agencies typically invite outside experts to form committees to serve and select eligible research.
Politicians don't micromanage usually, they just set broad outlines of funding.
The experts don't answer to the politicians.
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Funding agencies decide what the priorities are, issue a call for applications that satisfy those priorities, and pick among the ones that are scored highly by peer reviewers. A peer reviewer typically gets an application and is asked to score it on things like novelty, practicality, budget, etc. Decisions about what kind of research to fund, how many projects to fund, and specifically to this discussion, whether or not to fund multiple projects investigating the same thing, are made by non-experts who are
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Fair enough.
In my field, the high-ranking bureaucrats within the agencies were well-respected experts in their own right.
My field is not political; so I did not see any unpopular decisions.
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Medicine is certainly very political. For better or worse, the public actually sets a lot of research priorities. Sometimes that helps keep the scientists focused on things that matter, sometimes it results in spending zillions chasing pseudoscientific crap every knows isn't going to work.
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Far better to have more people working on it and to share information about each others failures
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If that were the case then why don't we get working vaccines or medications for other conditions any faster under normal circumstances. You act as though we have a good oracle to predict which treatments will work. The case is just the opposite with most medications failing in the early stages. Doing a full set of human trials is hideously expensive and no one would choose to develop a drug that won't pan out. Far better to have more people working on it and to share information about each others failures.
Well yeah, precisely. We don't know which treatments will work. The more variations being examined in parallel, the better.
And what failures are you referring to? Perhaps failures from the other 60+ vaccine trials going on at the same time? :-)
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I assure you, the people who develop these and the agencies that fund and regulate them are smart enough to figure out these things :-).
There's no "figuring out". There's just identifying successes and failures. You hear about the successes so you think the smart people just figure these things out. But if you think about all the things you haven't heard of us developing vaccines for yet (pretty much everything) it'll start to make sense.
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And don't forget the production of the vaccine: is it hard or easy? How much time for turnaround? How much capacity can be built?
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There should be some kind of review, though, that looks at the progress of all 70 and decides which 5 look the least promising and dump their resources into the other 65. I mean there's probably some chance that some of these efforts overlap significantly, too. This could be an iterative process that does a significant review of progress every 2 months and cuts out another 5 or so and diverts their resources into whatever most promising vaccine is most aligned with the efforts being dropped.
I definitely s
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There should be some kind of review, though, that looks at the progress of all 70 and decides which 5 look the least promising and dump their resources into the other 65.
Are the 65 most promising being limited by a shortage of resources though, or are you assuming that with 9 women pregnant you can get a baby in a month?
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My guess is that all 70 programs aren't backed by equivalent resources in terms of lab space, equipment, chemistry, or even localized access to other additional resources like researchers or ancillary technology and supplies. Plus some areas may be taxed in terms of community resources -- food, security, delivery, etc, because they are hot spots.
A vaccine in development effort in Omaha may be more handicapped than one done at the University of Minnesota, for example. U of MN has a high level of medical re
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The Bill & Melinda Gates foundation has been funding the creation of factories for seven of the most promising vaccines. If everything goes according to the plan, only two of those vaccines will continue to actually produce vaccines that will be used. I think this is probably the best strategy. It will not slow down the other vaccine studies in case none of those seven actually work. But if one or two seem to be working, then it will have accelerated the vaccines ending up to production.
Also if those fa
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Indeed! That's why the orange person being a jerk to China irks me. Sure, China did some stupid things, but wait until after the emergency and pose sanctions or something. That's the adult way to dole out punishment. Two wrongs don't make a right.
You don't pick a fight with your neighbor during a military invasion; same with a pandemic. The orange person has fewer people skills than even us nerds. (I realize I'm too blu
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Oh give him two weeks and China will be the US' best buddy according to him.
I'm just hoping he does cut funding for the WHO, lying sucking up scumbag pieces of shit that they are.
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He sure likes Kimmie's Valentines. He reads them to crowds like a proud grandmother. Kissing up seems to keep him at bay, at least for a short while.
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How is it the fault of WHO, seeing as they simply went by what the Chinese told them?
Is it the fault of WHO that the Donald cut the number of US public-health staff on the ground in China starting in 2017 by roughly 2/3 [reuters.com], and that, maybe, if he'd not done that, WHO might have had a more accurate idea about what was going on there, and when?
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lying sucking up scumbag pieces of shit that they are.
~Kokuyo
Wise up...
_reports from Wuhan_
2019-mid-December, Numerous cases of illness emerge from an open-air slaughter and seafood market.
2019-December 26, One of its workers, a man, is admitted to a hospital with symptoms of fever, tight chest, and week-long persistent cough. Doctors from Shanghai’s Fudan University genetically screen a sample of his lung tissue and report an “appearance” to SARS. Concurrently, a team from the Chinese Academy of Sciences in Wuhan analyze five patients and confidently conclude a viral infection similar to SARS.
*2019-December 30, Dr. Li Wenliang posts to WeChat** a warning to fellow med school grads to wear protective clothing to avoid infection when inspecting the suspected market for which he is forced to submit to signed admissions of disturbing society’s harmony and professionally isolated from further speculation conducive to wider panic.
2019-December 31, A man viciously stabs to death emergency room Dr. Yang Wen after she attempts to explain to him for 20 minutes the weeks-long deteriorating condition of his 95-year old mother and draws attention to an increasing crisis of China’s seven million medical workers providing the health care of 1.4billion people.
2019-December 31, Chinese government reports to W.H.O. a “cluster” of patients with symptoms of pneumonia and substantiated evidence of a virus, but without rigorous confirmation of its etiology (the cause, set of causes, or manner of causation of a disease or condition). *As reported by the New York Post https://nypost.com/2020/03/03/... [nypost.com]
**WeChat is China’s predominant social platform (replacing QQ). A “public facing” utility designed to mitigate commercial exploitation by “invite-only” permissions. Users’ profiles can be a “real ID” and any number of pseudonymous accounts to create “public interest groups” akin to Al Gore’s concepts of an infrastructure. WeChat’s functions include a chat client that supports text, emoji, audio, image, and video files, audio and video conference, file and location sharing.
***Asymptomatic transmission is commonly understood as infection from a “carrier” of illness who exhibits mild symptoms or none at all. COVID-19’s character of “invisible” transmission is a novel development in the history of potentially pandemic viruses but unsurprising as coronaviruses are categorized as RNA-viruses and highly mutable.
Technology always moves fastest in wartime (Score:1)
This is World War III, and this time all humanity is on the same side. Medical development and medical regulation will never be the same again.
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Nuke the Virus! Works on hurricanes.
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Not sure about World War III, but this time THE ECONOMY is at stake. So you know every possible resource will go toward snuffing this issue out.
This is crucial (Score:5, Interesting)
Finding a vaccine or drug effective against this virus is essential to preventing that huge spike in fatalities in the coming months. And despite the OECD nations already spending trillions to salvage their economies, they're gonna have to be the ones paying to get treatment to the developing world on humanitarian grounds (and to prevent more waves of the virus returning to their shores).
The only saving grace may be that the virus' death rate per million in equatorial nations and the southern hemisphere (which is just got off summer) remains curiously low. Suggesting the virus may have trouble surviving in warmer weather.
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Unlike the OECD nations, many of these countries lack medical infrastructure, equipment, trained personnel, and even general infrastructure
They also happen to be societies where people tend to walk far more and eat less unprocessed food. There are no third world countries with obesity problems and no, Oklahoma, Mississippi, Arkansas, Louisiana - and Wisconsin - don't count.
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"There are no third world countries with obesity problem"
The ten highest obesity rates are in Pacific Island nations. The eleventh is Kuwait. The US is twelfth: https://www.cia.gov/library/pu... [cia.gov]
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Hopeful, but ... (Score:5, Informative)
We have to be hopeful that a vaccine will eventually be developed.
However, there are other scenarios that can play out, for example:
- A definitive vaccine is found. Then the challenge is deploying it world wide, fight pockets of anti-vaxxers, and so on. Herd immunity will protect communities, mostly.
- A vaccine is effective but only for a short time. In that case booster shots are needed, e.g. Tetanus. Not too bad.
- The virus keeps mutating, and the vaccine is a moving target, just like the seasonal Influenza vaccine. Don't know how this will play out.
- No vaccine is possible. Just like HIV and Hepatitis C viruses have no vaccine. Even though some vaccines in the same family have a vaccine e.g. Flaviviridae Yellow Fever has a vaccines, yet Hepatitis C does not. Let us hope this is not the case.
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At least we have multi-med "cocktails" to keep HIV patients alive. Lack of a vaccine doesn't mean other mitigation techniques won't be found.
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It did take 30 years to figure out those cocktails.
However HIV and COVID-19 are completely different beasts.
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I remember it more like 15, at least for semi-successes. Anyhow, the total effort spent may be comparable, although some tests do take time to confirm. The resources being poured into CV is huuuge.
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For one thing, you have to get a bit closer than 2m from someone to catch HIV.
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Why bother to "fight pockets of anti-vaxers" at all? Just leave them to their own consequences.
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The problem is that there are vulnerable people with medical conditions that can't be given vaccines. Normally they'd be protected by herd immunity, but anti-vaxers create a hole in that that puts those vulnerable people at risk.
Doesn't mean there aren't other solution of course, like charge anti-vaxers with manslaughter if anyone in contact with them who couldn't be vaccinated dies, because, well, manslaughter is exactly what they'd have committed.
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Because those stupid fuckers walk among us. It wouldn't be a problem if we could just ship them off to some island.
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- No vaccine is possible. Just like HIV and Hepatitis C viruses have no vaccine.
Wouldn't the fact that the immune system can evidently fight off the SARS-CoV2 virus without treatment in most cases (as opposed to HIV/AIDS and Hepatitis C) suggest that a vaccine should be possible?
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Well, no.
The immune system is composed of lots of different pieces, and vaccines normally work by priming antibodies to recognize the invader. However there are some signs that COVID isn't being fought off by antibodies. I.e., abnormally low antibody counts of antibodies sensitive to COVID are found in recovered people. Sometime no sensitive antibodies. This may have other interpretations, but it may mean that a vaccine isn't possible. Perhaps it's being fought off by the innate immune system. But tha
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Even if a vaccine isn't possible, it's extremely likely that some drugs will treat the infection. We don't know which yet, but there are lots of them under investigation. (And I'm not really including the quinine family, which is only being seriously investigated because of overwhelming PR.) Getting one that you could take like an aspirin may take some time, but ones that can be used under medical supervision, possibly as an outpatient, might show up within months.
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We have to be hopeful that a vaccine will eventually be developed.
However, there are other scenarios that can play out, for example:
- A definitive vaccine is found. Then the challenge is deploying it world wide, fight pockets of anti-vaxxers, and so on. Herd immunity will protect communities, mostly. - A vaccine is effective but only for a short time. In that case booster shots are needed, e.g. Tetanus. Not too bad. - The virus keeps mutating, and the vaccine is a moving target, just like the seasonal Influenza vaccine. Don't know how this will play out. - No vaccine is possible. Just like HIV and Hepatitis C viruses have no vaccine. Even though some vaccines in the same family have a vaccine e.g. Flaviviridae Yellow Fever has a vaccines, yet Hepatitis C does not. Let us hope this is not the case.
Being "anti-vax" and being opposed to an individual vaccine that hasn't been through a long term study are different things and if we lump them together we risk giving the anti-vaxxers credibility.
Until we get a vaccine (Score:1)
Until we get a vaccine, we need new social rules and economic practices to ease economy back open. Possible examples:
- Seniors (retirees) stay social distanced. Only they are allowed out for exercise 9-11am and 9-11pm. One day a week is seniors-only shopping. A different day is seniors-only doctors.
- Sidewalks are made one-way (opposite of vehicular traffic for safety where there are no sidewalks).
- Office workers do 3 shifts of 3 days work at home, 2 days in office - MonThu, TueFri, WedSat. [Separated
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Taiwan, South Korea are fine with that due to production skills.
Other advanced nations are still working out what to import, how to test imported masks and if the mask they import actually work.
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- Seniors (retirees) stay social distanced. Only they are allowed out for exercise 9-11am and 9-11pm. One day a week is seniors-only shopping. A different day is seniors-only doctors.
I was actually surprised that one of the mid-sized grocery chains in my area decided against [wegmans.com] seniors-only shopping hours. Some other chains in my area did the exact opposite. Arguments for and against both make sense.
Economically Bad Idea (Score:3, Insightful)
A working vaccine is such an economically bad idea. You get to sell it once, and then you are done. Much better would be some sort of "treatment" that you can sell over and over again for a very high price. Something that only works once you catch the thing and does nothing more than prevent death. We have that for Influenza and it is called TAMIFLU. Look forward to TAMICORONA being on the market rather shortly.
Just the big ticket item needed to maximize pharma revenue!
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A working vaccine is such an economically bad idea. You get to sell it once, and then you are done. Much better would be some sort of "treatment" that you can sell over and over again for a very high price.
Just the big ticket item needed to maximize pharma revenue!
Sadly I'm sure this is actually being actively thought of/pursued by pharma CxOs everywhere.
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A working vaccine is such an economically bad idea. You get to sell it once, and then you are done. Much better would be some sort of "treatment" that you can sell over and over again for a very high price.
Just the big ticket item needed to maximize pharma revenue!
Sadly I'm sure this is actually being actively thought of/pursued by pharma CxOs everywhere.
I'm picking up a vibe among the super wealthy that they are more concerned with ensuring they aren't first against the wall. I think corona is going to give economists a way to tax the rich with out them just shifting their assets.
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A working vaccine is such an economically bad idea. You get to sell it once, and then you are done.
Sadly I'm sure this is actually being actively thought of/pursued by pharma CxOs everywhere.
No, you don't need a cigar-smoking comic-book capitalist villain for this to happen.
Reality is more subtle: the company working on the treatment has an easier time securing more funding, based on revenue projections, than another company who are working on a promising cure. The pharma people all feel they are doing the right thing, but the financial system creates a bad distribution of resources.
tt tag from a phone reeks of speculator (Score:1)
No existing coronavirus vaccine to modify (Score:1)
Finding an effective vaccine is not certain (Score:4, Interesting)
There's still some question about immunity retained after recovering from COVID-19, so there's no guarantee that a vaccine will confer long-term immunity. There are other mitigation strategies if that's the case (requiring periodic boosters, anti-viral drugs as treatment, etc), but it's too early to count on a vaccine as a magic bullet that will stop this disease in its tracks.
While it's likely that medical science will find a cure, the question is how long that will take -- it's been 40 years and hundreds of billions of dollars spent since the HIV crisis started and we still don't have a cure -- only treatments that keep the disease in check.
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I think that within a year we'll have a working vaccine and it'll be mass-produced like flu vaccine is, and we'll all be getting anti-coronavirus shots annually like we do for the flu.
I also think that the current crisis will be over before 2020 is over. We all just have to stay calm, calm people who are panicking, and above all stop hoarding everything. Everyone being so upset all the time over this is just making it that much worse f
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HIV is a special case and really shouldn't be used for comparison here.
I wasn't aware that we fully understand the immune response to this coronavirus -- while it's likely that a vaccine (or having the illness) gives immunity, it seems far from certain at this point.
I think that within a year we'll have a working vaccine and it'll be mass-produced like flu vaccine is, and we'll all be getting anti-coronavirus shots annually like we do for the flu.
That's what we're all hoping for (except for the annual coronavirus shot - I hope it doesn't mutate enough to require an annual shot like the flu)
I also think that the current crisis will be over before 2020 is over. We all just have to stay calm, calm people who are panicking, and above all stop hoarding everything. Everyone being so upset all the time over this is just making it that much worse for everyone.
I see very little hoarding, at least after the initial outbreak when the CDC suggested that people should keep 2 week of food on-hand, and people did just that so stores
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Exactly, people don't recover from HIV. People recover from this virus which means our body can fight it off, which makes a vaccine possible.
Open source vaccine (Score:5, Interesting)
Here's an open source vaccine design:
https://github.com/feraliscatu... [github.com]
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The basis for the most common cold is... not a virus.
The basis for the most common flu is... influenza.
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> The basis for the most common cold is... not a virus.
Yes, it is.
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Mea culpa. I meant to write "not coronavirus".
For some reason my spell check changed to "not a virus" and I failed to review before hitting submit.
I guess the Preview button is there for a reason.
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Understandable.
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The basis for the most common cold is... not a virus.
Yes it is, a rhinovirus in fact. Sometimes colds are caused by coronaviruses too.
The basis for the most common flu is... influenza.
Which are also viruses.
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Yes it is, a rhinovirus in fact.
You'd think that would be worse than a bat virus.
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So much wrong with this. You've got the world's store of information at your fingertips FFS.
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"The basis for the most common cold is... not a virus."
It is....a Rhinovirus.
https://en.wikipedia.org/wiki/... [wikipedia.org]
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I once caught a Hippovirus. It was fairly mild, I just went a bit hoarse.
Re:Cure for the common cold? (goodbye cliche) (Score:4, Informative)
Influenza vaccines don't even cover across strains.
Coronavirus is a very large family of viruses.
Rhinovirus is a most common cause of colds.
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Re:Cure for the common cold? (goodbye cliche) (Score:4, Informative)
No, it is not.
Of the 7 known coronaviruses, only 4 of them cause a cold.
Most of the time a cold is caused by one of the many hundreds of different rhinoviruses.
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I was going to correct you to "the seven known families of corona virus", but Wikipedia says it should really be "the seven known genera of corona virus".
IOW, there's lots more than seven species of corona virus that affect humans.
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No, there are not.
There appears to be (so far) exactly seven coronaviruses that affect humans. They are 229E, NL63, OC43, HKU1, MERS-CoV, SARS-CoV, and SARS-CoV-2. The last one is what causes COVID19. The first four of those are basically just variations of the common cold.
We do not classify them as "known" to imply there may be many more that currently exist and that we don't know about yet, because the infrequency with which new coronaviruses are discovered simply does not lend itself well to fav
Re: Cure for the common cold? (goodbye cliche) (Score:2)
The common cold is (usually) caused by a rhinovirus, not coronavirus.
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I perfectly understand. Isolation has made me horny, rude, and belligerent also. I've caught myself winking at the dog.
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I perfectly understand. Isolation has made me horny, rude, and belligerent also. I've caught myself winking at the dog.
Yeah, the Rona isn't causal to proclivity.