Hibernation Protein May Halt Alzheimer's 79
BarbaraHudson writes The BBC is reporting that tests show a protein called RBM3, involved in hibernation, may hold the key to regenerating synapses. In the early stages of Alzheimer's, and other neurodegenerative disorders, synapses are lost. This inevitably progresses to whole brain cells dying. But during hibernation, 20-30% of the connections in the brain — synapses — are culled as the body preserves resources over winter, and are reformed in the spring, with no loss of memory. Memories can be restored after hibernation as only the receiving end of the synapse shuts down. In a further set of tests, the team showed the brain cell deaths from prion disease and Alzheimer's could be prevented by artificially boosting RBM3 levels. Prof Mallucci was asked if memories could be restored in people if their synapses could be restored: "Absolutely, because a lot of memory decline is correlated with synapse loss, which is the early stage of dementia, so you might get back some of the synapse you've lost."
Further reading: here, here, and here"
Further reading: here, here, and here"
Exciting! (Score:1)
Could this be the last hurdle for successful cryostasis?
My wife works with people that have Alzheimer's and dementia. What a terrible way to go.
Re:Exciting! (Score:4, Interesting)
My wife works with people that have Alzheimer's and dementia. What a terrible way to go.
It's one of the reasons we legalized assisted suicide here (and probably elsewhere in the world). Nobody wants to end up that way. Maybe this will be a second option.
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i hope not. i can't imagine anybody choosing suicide over this. (IF this ever moves beyond the usual "lab rats regain memory" stage)
Re:Exciting! (Score:4, Interesting)
i hope not. i can't imagine anybody choosing suicide over this. (IF this ever moves beyond the usual "lab rats regain memory" stage)
I've already told everyone that if that happens, take me "out behind the barn and shoot me, and donate my body to science." What makes me me is my mind, not my arms, legs, heart, liver, or kidneys. When that's gone, the rest is just meat anyway, so might as well not consume further resources, and put people through the hassle of feeling guilty because they didn't visit "me" (even though nobody's home any more) often enough.I do NOT want to put that burden on my kids.
I keep my dogs until they can no longer live a quality life, then I take them to the vet and stay with them while they're killed. Doing otherwise (keeping a dog when it's terminally ill and suffering) would probably (and rightfully) get me investigated for cruelty. I think people have at least as much of a right to a life with some quality of life, and when that's no longer possible, help them end it. Apparently so do enough others to convince lawmakers to pass right to die legislation.
So hopefully this research will pay off and it won't come to that, but if it does, I'm going to pull the plug while I still can.
baseless speculation and hype (Score:1)
Given that humans do not, in fact, hibernate, there is little reason to think the mechanism present in the test species is identical and fully intact in humans. Furthermore, for all we know, the loss of hibernation ability is a necessary enabler of human-scale intellegence, and recovery of hibernation could cause retardation or something.
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Because Alzheimer's doesn't cause "retardation".
Re:baseless speculation and hype (Score:5, Informative)
Because Alzheimer's doesn't cause "retardation".
Obviously I couldn't put everything in the summary (I provided 4 links) A few points: First, the same protection was observed with higher levels or RBM3 in mice that didn't undergo induced hibernation as with those who underwent induced hibernation:
In the grand finale set of experiments, the researchers bypassed cooling and injected lentiviruses expressing RBM3 directly into the hippocampi of mice early in prion disease. They achieved a threefold overexpression of RBM3 that afforded the mice the same synaptic, behavioral, and survival benefits that early cooling had, and rescued flagging protein synthesis observed in neurons nine weeks post-infection. Boosting RBM3 expression also allowed synapses in both neurodegenerative disease models to recover completely after cooling. Conversely, knocking down expression of RBM3 accelerated disease progression in the prion model, and hastened synapse loss in both models. Synapses and memory even took a hit in normal mice deprived of RBM3 expression, as they lost synapses and did not recognize novel objects as well as control mice. This suggested that the cold-shock protein may play an important physiological role in normal synapse upkeep.
Mallucci hypothesized that RBM3 promotes synaptic plasticity and staves off neurodegeneration by raising levels of protein synthesis in dendrites. “Synapses are so dependent on their key synaptic proteins for assembly and function,” said Mallucci. Because synapses often reside distant from the cell body, local translation at the dendrite is important to ensure a ready supply of such proteins and thus facilitate synaptic recovery, she added.
So we know that RBM3 protects regardless of whether it was produced by hibernation or artificial elevation of just the protein RBM3.
Second we already know cooling of the brain in humans is also protective:
A state of hypothermia is known to protect the brain. People have been survived for hours after a cardiac arrest without brain damage after falling into icy water. Similiarly, cooling the brains of babies that have suffered a loss of oxygen at birth is also used to protect against brain damage.
"We’ve known for some time that cooling can slow down or even prevent damage to brain cells, but reducing body temperature is rarely feasible in practice: it’s unpleasant and involves risks such as pneumonia and blood clots," said Professor Giovanna Mallucci, who led the research team, at the Medical Research Councils Toxicology Unit at the University of Leicester. "But, by identifying how cooling activates a process that prevents the loss of brain cells, we can now work towards finding a means to develop drugs that might mimic the protective effects of cold on the brain."
So there is reason to think that the same mechanism might work in other mammals, and not just those who hibernate. We'll only know when human trials commence, but considering what's at stake, there will be literally millions volunteering to be test subjects.
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BarbaraHudson got her/his tranny ass kicked again and ran http://slashdot.org/comments.p... [slashdot.org]
Apparently you don't like LBGTt peeps. Not sure if it's your blatant homophobia or just the totally inane bringing in of sexual choice to a science article.
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Wrong: BarbaraHudson cheats moderation by sockpuppets http://science.slashdot.org/co... [slashdot.org] and that is dishonorable and scumbaggish. Most could care less if BarbaraHudson was foolish enough to attempt to become a woman, which he/she is not by a long shot. Get real.
Attack the deed not the person. By attacking her gender choice you show yourself to be less than an idiot and certainly not brave enough to be a man.
Use it or lose it (Score:1, Interesting)
I expect we'll be hearing more about video game fitness and therapy for senior citizens. Not necessarily FPS type games, but perhaps light strategy games, possibly with a kinesthetic component.
But but buit.... (Score:1, Funny)
I don't want those memories back. Just want my brain to work right. I spent many dollars buying booze to forget; why would I wast that money!
Comment removed (Score:5, Funny)
Now this is good news... (Score:2)
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Re:Memory (Score:5, Interesting)
Re:Memory (Score:5, Interesting)
I think you have cause and effect reversed - mostly people (of all ages) are put in homes because they already require 24-hour supervision and care. If they can't get dressed, go to the bathroom, make their own food, know approximately what time of day, day of the week, and month of the year, and they show increasing bouts of rage, they're a danger to both themselves and those around them. Try taking care of someone and having them accuse you of all sorts of ridiculous stuff, like stealing stuff that a quick search shows they misplaced, or taking a harmless remark or action and twisting it around when they retell it to the whole family. Taking care of someone by yourself under those conditions is hazardous just from a legal perspective.
Also, I would question whether "unimportant memories are routinely deleted." How many times have you forgotten things like passwords, birthdays, where you left your smartphone, wallet, purse, or keys, your own phone number, and yet can clearly recall the punchline of really stupid jokes?
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Often the elderly are put in homes because their relatives want their money, and distress at being stripped of their freedom and rights is considered proof that they need to be confined.
And for those who are put in homes who have no money or property of their own in the first place? And the millions of seniors below the poverty line? And the ones who have some money, but not enough to pay for living in a home, so others have to make up the difference? They're certainly not put in homes for their money.
Sometimes it's the only safe thing to do. They have better access to doctors, they have nurses on staff 24/7, and if they cannot take care of themselves, what other option is there? None, r
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You obviously dont know crap. It costs a SHIT-LOAD to put someone in a nursing home. Far more money than can be gained by raiding grandma's savings and land. Because the monthly cost is based on the persons wealth.
Gonna steal grannies $22,000,000 real estate? not gonna work as the state and the home will get it first.
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Re:Memory (Score:4, Informative)
Very emotional post. Sorry to bring logic into it. Care homes cost a lot of money. $3 - 5 k a month isn't unusual for basic nursing care. If I wanted my relatives money, the very last thing I would do is put them in a home, where they might live another 5 years and burn through every dime they have.
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"Disease" is an unfortunate label because it implies a pathogen and there is none for Alzheimers."
Hate to reply twice, but "disease" covers much more than illnesses caused by pathogens. The various forms of diabetes, for one. Osteoarthritis, glaucoma, cataracts ...
Q. "Definition of disease"
A.. disease
noun
a disorder of structure or function in a human, animal, or plant, especially one that produces specific signs or symptoms or that affects a specific location and is not simply a direct result of physical injury.
Re:Memory (Score:4, Insightful)
In this case pronouncing the word "disease" is a slack way of dismissing the symptoms of dementia without any futher (sic) thought.
Most people who call dementia a disease do not dismiss the symptoms, especially considering the huge impact those symptoms have on both the patient and those around them.
Also, when you wrote "One girl asked, "Is it true that in your country you send old people off to live alone?", you didn't take into account that the average lifespan in many parts of Africa the life expectancy is below 50, and in some parts (Sierra Leone) it's below 40. The average - a puny 52 years. So when that little girl asked her question, she wasn't referring to "old people", but middle-aged people at best. She probably hasn't even seen an old person with dementia.
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Actually, that's a common mis-interpretation. The average lifespan is low mostly due to infant mortality. Same deal for the west during the middle ages.
In general, I agree with you here. Alzheimers is not manageable outside of a nursing home for long. It may not be as big of a problem in Africa due to the likelihood of accidental death once dementia begins.
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AIDS is a significant lifespan factor in some countries as well.
In Africa (and previously everywhere), people tend to live in large extended families where there's plenty of people around to share the responsibility of taking care of the old and their dementia. Plus of course they have no money to involve a doctor.
Re:Memory (Score:5, Interesting)
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There are various 'kinds' of memories. ... I guess there are things in between that are stored as a combination of both.
Parts are 'constructed' as synaptic connections, this happens especially with physical abilities, like playing a gittar or doing sports.
Others, like mere facts, are stored as RNA
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Which is why if you train for it, it is not hard to lie your ass off in a polygraph and pass it with flying colors.
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Can't you go back to whining about beta?
Keep it away from your pet chimpanzee!! (Score:2)
I think we all know how that works out.
Only side effect is (Score:2)