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Medicine

First Birth From Human Womb Transplant 120

BarbaraHudson (3785311) writes The headline sounds like something from the tabloids — "Woman becomes first to give birth from transplanted womb — using one donated from her own mother.'" But it's from The National Post, quoting The Lancet: "The breakthrough was reported by The Lancet medical journal on its website last night. It is thought the birth occurred within the last month after doctors transplanted wombs into several women who had a rare genetic condition that meant they were born without their own womb. In January, one of the patients underwent in-vitro fertilization treatment that resulted in an embryo being transferred to her new womb. The donated womb came from the woman's own mother, so the baby is also the first born to a woman using the same womb from which she emerged herself. In wake of the Lancet article, the Swedish team refused to confirm a baby had been born, saying: "As soon as there is a scientific peer-reviewed paper, we will comment on this. I will provide you with information as soon as we have some." Eight of Dr. Brannstrom's patients received their wombs from close relatives, reducing the risk of their bodies rejecting them." There's nothing at The Lancet online yet." There is, though, an article at the BBC.
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First Birth From Human Womb Transplant

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  • by Rande ( 255599 ) on Saturday October 04, 2014 @04:48AM (#48061821) Homepage

    ...doesn't mean that you _should_.

    In this case, what happens when the child has the same genetic defect? Pass the womb on 3rd hand?

    • by Anonymous Coward

      invitro so might not be her egg.

    • by burni2 ( 1643061 ) on Saturday October 04, 2014 @06:00AM (#48061991)

      Well sience has 20 years to find a solution for that.

      Btw. what you ment with "should" is, that you want to hinder reproduction - natural and assistent - because of the possibility of transfering a birth defect.

      To paint the picture you could also say "Sterilize the genetically disabled"

      Or to go further, why should you support disabled people who cannot care for themselves, naturally they would die!?

      My answer to this is: because it's the difference between humane and inhumane.

      • Or to go further, why should you support disabled people who cannot care for themselves, naturally they would die!?

        Whoa, there's a big difference between caring for your damaged and defective, and making more defectives. I chose not to breed in part because of the lack of familial support and in part because I don't think my genetics are all that fantastic. The "Espinoza Curse" includes respiratory problems in addition to the cute nose and huge wang ;)

        • by burni2 ( 1643061 ) on Saturday October 04, 2014 @01:32PM (#48063865)

          Is that difference really that big?

          If you look into the history of eugenics you can clearly see that both arguments (sterilizing disabled and euthanasia of so called "unworthy life") come from the same way of thinking - rationalism.

          And well (nazi)germany has implemented both - crimes against humanity, however the philosophy of total rationalism (which eugenic & euthanisia) was discussed in many other countries at that time including (pre-nazi)Sweden and Great Britian.

          In Sweden(yes Sweden the country of the Nobel prize!) till the early 1990s disabled people were being sterilized - this btw. does not only include physical or cognitive disabilities but also cases of psychiatric patients.

          And you said it yourself you "chose" not to breed,
          nobody made the choice for you.

          There is no real difference between both solutions:

          Because they both stem from the same "total rationalistic" way of thinking. The totalitaristic rule of the total rational thinking, will treat human life and freedom of choice being somewhat expendable and hindering.

          • And you said it yourself you "chose" not to breed,
            nobody made the choice for you.

            Yeah, there's a big difference between those two things, too.

      • by MrL0G1C ( 867445 )

        Personally I think allowing people who can not care for themselves to be born is absolutely inhumane.

        • Personally I think allowing people who can not care for themselves to be born is absolutely inhumane.

          Well, I guess that takes care of the human race ... no human can take care of themselves without a lot of care in the first few years, and even later we still depend on each other as a society, to provide jobs, policing, etc.

          Or we could go all Romulus and Reemus, and let the wolves raise our kids :-)

          • by MrL0G1C ( 867445 )

            I'm thankful that I don't have any disabilities yet. I enjoy cycling, if I received brain-damage that disabled me and altered my personality then I'd like the state to put me down!

            Being an able-bodied person means a lots to me, I wouldn't want to be born as a disabled person.

            • by burni2 ( 1643061 )

              Perhaps you will think differently when you became disabled?

              Btw. the logic way would be that you start only doing indoor cycling, because otherwise you take higher chances to become disabled.

              But it's your own choice to end your life if this happens. Perhaps someone at Silk Road X sells red pills and you can pre-order some? And as a precaution you should make a "patients testamony" that you don't want life extending treatment.

              • by MrL0G1C ( 867445 )

                Perhaps you will think differently when you became disabled?

                I very much doubt it.

                • Perhaps you will think differently when you became disabled?

                  I very much doubt it.

                  Maybe, maybe not, but that's not germane to the point at hand. Most of us would agree with you. I've told my relatives "take me out behind the barn, shoot me, and harvest anything that can be of use to someone else" if there's not enough functioning brain to continue to "be me". Or if the quality of life got so low that you wouldn't let a dog suffer that much.

                  But there's no evidence that a womb transplant will result in people who are unable to care for themselves less than anyone else after they reach

                  • by MrL0G1C ( 867445 )

                    I'm not against the womb transplant if it works, and I wouldn't deny medicine the chance to perfect the operation etc. Just against people having children that wouldn't be able to support themselves when they become adults. What would be wrong is if it was known that the woman with the transplant would give birth to a child also without a womb, but I'm guessing that's not the case.

                    • Well, while they're in there, they could always implant some cameras inside to check on the health of the fetus - you know, a "womb with a view" :-)

                      Though knowing people, other women would want the same, so that they can constantly update their facebook status with the latest pics of their unborn child. Or worse, a live stream. And then the cops will get involved, because in their efforts to expand their budgets, that too falls under the definition of producing and distributing child pornography. And t

      • by Reziac ( 43301 ) *

        There's a big difference between "sterilize the disabled" and "don't preserve a genetic defect by helping it reproduce when it couldn't do so on its own".

    • by ImprovOmega ( 744717 ) on Saturday October 04, 2014 @09:48AM (#48062635)
      That would seem statistically unlikely. The womb itself does not contribute to the genetics of the person and presumably it's possible to not have a uterus but still have ovaries. In this case the woman's defect would almost certainly be canceled out by the man's sperm since even though she is a carrier, it is incredibly unlikely that he is also, and even if so it's a 50/50 proposition. It's completely and utterly different than inbreeding in which you're recombining the same defects.
      • In this case the woman's defect would almost certainly be canceled out by the man's sperm since even though she is a carrier, it is incredibly unlikely that he is also, and even if so it's a 50/50 proposition

        Genes do not always work that way! Goodnight!

  • Amazing progress... (Score:5, Informative)

    by Elledan ( 582730 ) on Saturday October 04, 2014 @04:52AM (#48061833) Homepage
    Amazing progress, but it would be nice if the attitude within the medical scientific community to for example intersex-born individuals wasn't still stuck somewhere in the 19th century. Progress is relative.

    How many people here actually know what intersex is? I didn't know it existed (among humans at least) or what it was called until I was 21 and I was born intersex (hermaphrodite).

    Don't get me wrong, it's great that these women born without certain reproductive organs are getting them transplanted, but on the other side doctors are also chopping up the genitals of intersex infants and manipulating intersex adults like yours truly into 'normalization' surgeries.

    Heck, after consulting dozens of 'experts' in about a dozen countries I honestly couldn't tell you which reproductive and related organs I do or don't have exactly. I also meet so many others who had to discover as a teenager or adult that their parents and medical file have withheld details about surgery being performed on them as an infant.

    So yes, happy news for some, but just a bitter feeling for many others who had the misfortune of not being born a 'normal' male or female even one missing some bits...

    Excuse the brief rant :)
    • What on earth does this have to do with the topic at-hand? Do you post this on any medical science related story?

      • It is related to the topic at hand. This procedure possibly allows some of those who are intersexed and whose reproductive organs are not sufficiently developed for either sex, or whose reproductive options were removed without their knowledge or consent when they were young, to carry a child.

        Now what most women want to see is the replication of the situation in John Brunner's "Stand on Zanzibar", where men are complaining about back pain, morning sickness, job impact, etc., because it's "their turn" to c

        • The human race would die out.

          Assume they flip a coin for who has to be pregnant first...0.50 children per family (assuming the woman is fool enough to carry one if she looses the flip)

    • by PeeAitchPee ( 712652 ) on Saturday October 04, 2014 @07:02AM (#48062083)
      Indeed. There is still a lot of womb for improvement.
    • by Anonymous Coward

      They chop up genitals of normal male infants too. Don't take it personally.

    • I do. I learned it in 1990. For the the most annoying thing about TFA is the use of the word "womb", as if this were 1814 not 2014. Are we really afraid of the word UTERUS?
      • by Elledan ( 582730 )
        'Uterus' sounds too scientific and medical, I guess :) I'm pretty sure most of the population has no clue what it is if you ask them.
  • by Bob_Who ( 926234 ) on Saturday October 04, 2014 @04:55AM (#48061837) Journal
    Talk about hand me downs, this makes wearing you mothers wedding gown or grandmothers wedding ring seem like a quaint gesture. Re-gifting doesn't come close to re-wombing in terms of tradition and family heritage....
  • by Anonymous Coward

    Boy.
    Born with C-section.
    1775 grams
    No special care needed for the baby.

    Some contradictions (to the slashdot summary) regarding who the womb came from. 61 year old woman, no relation.

  • We hurd u liek babbies, so we took the womb you were in and put it in you, so now you can be a mom with your mom's mom parts. etc etc
  • "...the baby is also the first born to a woman using the same womb from which she emerged herself."

    Can't imagine the deja vu Vulcan Womb Meld that just got created between baby and mother with this one.

    "What is your earliest thought?"

    "The feeling I've been here before."

  • Other people's wombs have been used before, though not deliberately: They were using their own twin's womb because they were a chimera. http://en.wikipedia.org/wiki/L... [wikipedia.org]
  • This, with artificial implantation and genetic engineering, brings us one step closer to asexual reproduction. It won't be long before science is able to pair DNA from two women to create a new offspring. Artificial wombs will follow. Soon women won't need men any more. Then the male geeks will go from having had a limited chance, to having zero hope of ever meeting a woman and having sex.
    • Artificial wombs will follow. Soon women won't need men any more. Then the male geeks will go from having had a limited chance, to having zero hope of ever meeting a woman and having sex.

      Technically, it's the other way around: If having a biological womb you've been born with isn't a requirement for human reproduction anymore, it's the *MEN* who don't need women any more.

      The male geek could get implanted with the necessary womb to give birth to children without ever needing to meet a girl (and an advantage: in mammals, mixing male genetic material can give birth to both male and female offsprings (you have both X and Y sex chromosome to pick from) unlike when mixing female (only X available

      • That is an interesting question - what if you end up with a YY chromosome pair. I wonder what would happen?
    • This, with artificial implantation and genetic engineering, brings us one step closer to asexual reproduction. It won't be long before science is able to pair DNA from two women to create a new offspring. Artificial wombs will follow. Soon women won't need men any more. Then the male geeks will go from having had a limited chance, to having zero hope of ever meeting a woman and having sex.

      Oh, you think women only put up with sex with males because they get babies out of it? Dude, there are sexist, racist, white bread men from the 1950's looking at you saying, "oh no he dint!"

      Maybe you are rationalizing why you never get any? :-)

    • This, with artificial implantation and genetic engineering, brings us one step closer to asexual reproduction. It won't be long before science is able to pair DNA from two women to create a new offspring.

      I just wanted to point out that these are two different things. If there's two organisms involved then it's sexual reproduction. For it to be truly asexual you would have to fuse genetic material from two eggs from the same woman - this is actually worse than inbreeding a brother and sister because *every* bad recessive gene you have has a 50/50 chance to present both copies in the offspring. With siblings at least about half your genes are different. Two different women wouldn't present this problem, b

    • See "Houston, Houston, Do You Read ...?" [wikipedia.org] by Alice Sheldon, pen name James Tiptree Jr. The wikipedia summary fails to capture the true feeling of the story. Definitely a must read for any sci-fi fan.
  • This summary makes no sense.

    It is thought the birth occurred within the last month after doctors transplanted wombs into several women who had a rare genetic condition that meant they were born without their own womb.

    So did it, or didn't it? How do you not know when the birth took place?

  • Adopt! (Score:5, Interesting)

    by Charliemopps ( 1157495 ) on Saturday October 04, 2014 @07:41AM (#48062167)

    I will forever be thankful for our fertility doctor. We sat in front of him and he told my wife she could never bare children. She asked "what can you do?" He smiled and said "Given enough hope and money, there's practically no end to what I could do. But there are desperate children all over that need parents. It may be that life is giving you a hint." That line will remain with me for the rest of my life because it rang so true and cut through the bullshit of modern life.

    I'd not thought of adopting... and I immediately thought "That will be a hell of a lot less work and my wife wont get fat!!"

    I was wrong on both accounts in the end, but, I'm currently the proud father of the best son a father could ever have. Standing on the outside and looking at it you think you could never love an adopted kid the same as you would your own flesh. But I'm here to tell you that you can and will. He is my son. He knows he's adopted and he thinks it's cool. He brags to his friends that "His parents went all the way to Africa for him!"

    Anyway, I find it sad that we go to such extreme, untested and dangerous lengths to solve a problem that already has a very simple solution. Adopt, you wont regret it.

    • I'm glad your story turned out well, but if your physician really told you, "It may be that life is giving you a hint." then he was overstepping the bounds of ethical treatment. It's none of his fucking business what you choose, his business is to listen to what you *want*, and tell you what he can *do* for you.

      The Dr. Phil homespun bullshit should be grounds for censure from the medical board.
      • I must say that it is _completely_ ethical to discuss adoption with fertility patients. Depending on the medical issues, they can be dangerous for the mother and the fetus, draining for both parents, and hideously expensive whether or not covered by insurance. It is the doctor's role to explain the _options_ and their consequences.

        There are many equivalents. A lifestyle change can often be more effective treatment than the most extensive medication or surgery, whether it be moving to a better climate to ea

        • There's a difference between providing information about adoption and saying, in effect, "Hey, life is telling you not to attempt to reproduce." That is offensive.
          • There's a difference between providing information about adoption and saying, in effect, "Hey, life is telling you not to attempt to reproduce." That is offensive.

            The only way that makes sense is if you see adoption as a bad thing... or a negative. That's on you... not the doctor.

      • I'm glad your story turned out well, but if your physician really told you, "It may be that life is giving you a hint." then he was overstepping the bounds of ethical treatment. It's none of his fucking business what you choose, his business is to listen to what you *want*, and tell you what he can *do* for you.

        The Dr. Phil homespun bullshit should be grounds for censure from the medical board.

        Our well-being was his business. He was completely correct in what he said. This is exactly the sort of discussion fertility doctors should be having. Most of the other families that went with us to Africa had already spent tens of thousands of dollars on pointless and sometime dangerous fertility treatments with disreputable fertility doctors.

        After having been through the experience, I'd even say that adoption should be the first choice for reproductively healthy couples. Within a few months your adopted c

      • Doctors aren't walking prescription pads that you go to after you diagnose your symptoms online. Doctors are supposed to do the best thing for you, whatever that is - what you think you want from them is obviously a very strong factor, but certainly not absolute. A physician may absolutely be taking the ethical high ground by refusing your demands - say, for antibiotics for a cold, or a medically-unnecessary amputation for apotemnophilia [wikipedia.org], or even seeing you at all if you're stupid enough to be unvaccinated

        • And you're still not getting it. The doctor intruded his personal view into a doctor-patient relationship. It's absolutely ethical, even obligatory for a fertility doctor to inform his patients about the cost, difficulty, and low probability of success of the services he can provide, he can also mention that adoption is another option, but the way the original poster quoted him, "It may be that life is giving you a hint." You don't seem to understand how that crosses the line.

          And far from "people like m
  • Eugenics (Score:2, Interesting)

    by MrL0G1C ( 867445 )

    To many this may be considered flamebait, but it is my honest opinion and deserves discussion.

    I think that if you have serious genetic problems then you shouldn't be having children if those genetic defects are going to be passed on. Yes nobody is perfect I realise that. It just seems to me that the majority of humans are not able to think rationally when it comes to genetics/eugenics. Why am I saying this? - Because the % of the population with disabilities that require care is growing exponentially, the o

    • by MrL0G1C ( 867445 )

      correction: "525,000,000,000 sperm" when is slashdot going to get an edit option?

    • Two problems with your thinking:

      1 - "population with disabilities that require care is growing exponentially" This is pure bullshit. Either you know nothing about the trend of incidence of disabilities in children, or you don't know what "exponentially" means. Citation, please. Oh, and be careful if you post a reference that it not show a higher incidence only because the rate of reporting is increasing. That's bullshit too.

      2 - You didn't say what you believe "shouldn't be having children" means. Doe
      • by MrL0G1C ( 867445 )

        3) Is not a straw man argument, why should the 2 sperm that make it be allowed to live, they are no more special than the billions that didn't make it, in this particular case they are worse.

        2) Shouldn't be having children that would not survive without car and can earn their keep in society.

        1) Shout at me for not giving citation but didn't give citations yourself for your counter-argument. (I'm having a look, but I'm getting an ocean of results which don't answer the question either way).

      • by MrL0G1C ( 867445 )

        re 1: After a bit of research, I'm starting to think that I was duped by some crap article in the past. A lot of disabilities are due to environmental factors such as smoking etc and half the time the cause is unknown, leaving only 20% of disabilities at birth being due to genetic inheritance, and disabilities at birth are a small percentage of the total.

        But I still don't know now what the trend in disabilities at birth due to genetic inheritance is, got any links?

  • by Anonymous Coward

    Livebirth after uterus transplantation [PDF] [thelancet.com] (with pictures of the uterus! :-) ).

  • Since the egg came from her mother the baby would actually be her sister, or brother.

    • by Anonymous Coward

      No. Eggs come from the ovary, not the uterus. The woman did not get a transplant of her mother's ovary, nor did she get an implant of her mother's egg. She had her own ovaries.

  • Reminds me of the story by Heinlein, All You Zombies [uca.edu].

  • Since the womb was donated from her mother, doesn't that make her child her sister?
  • ... "Offline". Meaning, have the wombs be stand-alone.
    That would solve the 1mm people on Mars dilemma

"I'm a mean green mother from outer space" -- Audrey II, The Little Shop of Horrors

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