Researchers Find "Achilles Heel" of Drug Resistant Bacteria 106
Rambo Tribble writes Researchers in Britain are reporting that they have found a way to prevent bacteria from forming the "wall" that prevents antibiotics from attacking them. “It is a very significant breakthrough,” said Professor Changjiang Dong, from the University of East Anglia's (UAE) Norwich Medical School. “This is really important because drug-resistant bacteria is a global health problem. Many current antibiotics are becoming useless, causing hundreds of thousands of deaths each year. Many bacteria build up an outer defence which is important for their survival and drug resistance. We have found a way to stop that happening," he added. This research provides the platform for urgently-needed new generation drugs.
HOPE to exploit it (Score:5, Informative)
From TFA ... researchers have discovered what causes anti-biotic resistance, and HOPE to use that to discover how to stop them from becoming resistant.
The summary suggests that they already have. The summary will be perfect in "a few years time" when the researchers hope to have the solution.
Re:e. coli and salmonella? (Score:5, Informative)
Re:e. coli and salmonella? (Score:5, Informative)
Re:What's with the quotes around "gram-negative?" (Score:5, Informative)
Re:Easier (Score:5, Informative)
Purell is alcohol based (good ole' ethanol). That has nothing to do with antibiotics and the antibiotic resistant bacteria in TFA.
Antibiotic resistance (Score:2, Informative)
One of the main mechanisms for antibiotic resistance is efflux pumping. Drug makes it across the membrane and then is pumped out before it can reach a lethal concentration. If you can attack the cell from outside then you can sidestep this mechanism.
There are a natural class of antimicrobials called Protegrins that usually insert into the membrane from outside and combine to form a pore, spilling the cell contents. If you modify these you can make them lethal without forming a pore and in this state the protein they bind to (with low nanomolar affinity) is LptD (http://www.ncbi.nlm.nih.gov/pubmed/20167788) - one of the protein structures discussed. With a structure of the target there is a bit more information to guide development of these.
Re:The Reason... (Score:5, Informative)
Yeah, don't think so. I suggest this chart: http://www.infoplease.com/ipa/... [infoplease.com]
The age of mortality for non-infants (those living past age 10) has increased by 20-25 years, a 50% increase in life expectancy, in the past century. Even if you look at "adults", or those who make it to age 20, there is still a 17-23 year increase. Again, a 50% increase in longevity for adults.
Re:e. coli and salmonella? (Score:5, Informative)
Further, the use of the term "immunity" to describe antibiotic resistance is a pet peeve of mine, as these terms do not mean the same thing!