New Treatment Kills Metastatic Cancer Cells 55
robert2cane points out a promising study from Cornell University about controlling the spread of cancer. There are many treatments for an isolated tumor, but once cancer cells reach the bloodstream and start spreading through the body, it's much more difficult to control. The new research (PDF), led by Michael King, developed a compound that is able to target and eliminate cancer cells in the blood of mice.
"When attempting to develop a treatment for metastases, King faced two problems: targeting moving cancer cells and ensuring cell death could be activated once they were located. To handle both issues, he built fat-based nanoparticles that were one thousand times smaller than a human hair and attached two proteins to them. One is E-selectin, which selectively binds to white blood cells, and the other is TRAIL. He chose to stick the nanoparticles to white blood cells because it would keep the body from excreting them easily. This means the nanoparticles, made from fat molecules, remain in the blood longer and thus have a greater chance of bumping into freely moving cancer cells. There is an added advantage. Red blood cells tend to travel in the center of a blood vessel, and white blood cells stick to the edges. This is because red blood cells are lower density and can be easily deformed to slide around obstacles. Cancer cells have a similar density to white blood cells and remain close to the walls, too. As a result, these nanoparticles are more likely to bump into cancer cells and bind their TRAIL receptors."
Re: (Score:2)
Re: (Score:3)
Re: (Score:2)
As someone who does research in this topic and has an IQ of 9001, I think the paper was just fine. You can believe me, I'm on the internets.
Yes, but you're a dog!
Re: (Score:1)
That's why he was the one to write the summary!
Re: (Score:2)
Better headline (Score:4, Informative)
"New treatment kills some but not all metastatic cancer cells in mice, but only while they're traversing the bloodstream and so far only when the cells are injected into the mice in the first place".
Comment removed (Score:5, Interesting)
Re: (Score:1)
Re: (Score:2)
Re:thru lymphatic system (Score:4, Insightful)
What would set this research apart is it's ability to kill metastasizing cancer.
It is not a useless advancement, but it apparently needs to also kill cancer present in distant organs to be of significant impact.
Re: (Score:2)
It is still useful if it only kills cancer in the process of metastasis so long as is used early enough. A single tumor is much more likely to be successfully treated than a bunch of diffuse tumors.
Re: (Score:1)
We all hope so.
Landmark cancer studies cannot be replicated (Score:1)
http://www.collective-evolution.com/2012/04/21/cancer-industry-exposed-as-fraud-the-science-is-false/
"Recent news has shown that the majority of studies geared towards cancer research are inaccurate and likely fraudulent by nature. Findings published in the journal Nature show that 88% of major studies on cancer that have been published in reputable journals over the years can not be reproduced to show their accuracy. This means that the research findings published are not based on accurate results."
Still,
Re: (Score:3)
Here is the actual article in Nature (because the linked story doesn't actually provide it):
http://www.nature.com/nature/journal/v483/n7391/full/483531a.html [nature.com]
Re: (Score:2)
That's why studies need to be replicated. It's wrong for all the credit to go to the initial discoverers/reporters.
How long do metastatic cancer cells remain in the (Score:5, Interesting)
Physicist Lowell Wood in a brainstorming meeting: a question for everyone. You have a tumor, and the tumor becomes metastatic, and it sheds metastatic cancer cells. How long do those circulate in the bloodstream before they land?’ And we all said, ‘We don’t know. Ten times?’ ‘No,’ he said. ‘As many as a million times.’ Isn’t that amazing? If you had no time, you’d be screwed. But it turns out that these cells are in your blood for as long as a year before they land somewhere. What that says is that you’ve got a chance to intercept them.”
How did Wood come to this conclusion? He had run across a stray fact in a recent issue of The New England Journal of Medicine. “It was an article that talked about, at one point, the number of cancer cells per millilitre of blood,” he said. “And I looked at that figure and said, ‘Something’s wrong here. That can’t possibly be true.’ The number was incredibly high. Too high. It has to be one cell in a hundred litres, not what they were saying—one cell in a millilitre. Yet they spoke of it so confidently. I clicked through to the references. It was a commonplace. There really were that many cancer cells.”
Wood did some arithmetic. He knew that human beings have only about five litres of blood. He knew that the heart pumps close to a hundred millilitres of blood per beat, which means that all of our blood circulates through our bloodstream in a matter of minutes. The New England Journal article was about metastatic breast cancer, and it seemed to Wood that when women die of metastatic breast cancer they don’t die with thousands of tumors. The vast majority of circulating cancer cells don’t do anything.
“It turns out that some small per cent of tumor cells are actually the deadly ones,” he went on. “Tumor stem cells are what really initiate metastases. And isn’t it astonishing that they have to turn over at least ten thousand times before they can find a happy home? You naïvely think it’s once or twice or three times. Maybe five times at most. It isn’t. In other words, metastatic cancer—the brand of cancer that kills us—is an amazingly hard thing to initiate. Which strongly suggests that if you tip things just a little bit you essentially turn off the process.”
Re: (Score:3, Informative)
Forgot to attribute the above to the New Yorker Magazine (http://www.newyorker.com/reporting/2008/05/12/080512fa_fact_gladwell/?currentPage=all)
Re: (Score:2)
Re: (Score:3)
Re: (Score:2)
I've read that eating enough green plant matter (leaves) will remove waste from the blood. I've read in several places that people have used vegan diets to control cancer (although I think it's more about eating more leaves, and not about rejecting protein).
I've heard/read that people that live a more primative lifestyle without our grain based diets don't have cancer, presumably because they eat more leaves.
GBOMBS foods to fight cancer (Score:2)
http://www.drfuhrman.com/library/gbombs.aspx [drfuhrman.com]
G-BOMBS: Greens, Beans, Onions, Mushrooms, Berries, and Seeds
Fasting sometimes can help too (consult a specialist in it like Dr. Fuhrman to see what is reasonable to expect in various situations). People are always getting (pre)cancer cells and the immune system destroys them usually. Generally cancer is best prevented by diet and lifestyle (including avoiding carcinogens including browned and burned foods with acrylamides) with a healthy immune system. But once y
Re: (Score:2)
This is what I love about physicists: They love sanity checks, and they do the math.
I'm in bioinformatics, and where I work we were discussing how large a value for differential gene expression could get and still be considered credible. Well, it turned out that if a single molecule of a typical RNA transcript is present in a reference sample, the value that was under consideration would require several thousand metric tons of it in the comparison sample. This was deemed to be "unphysical", as they say...
cimetdine... (Score:1)
Hair as a standard for measurement (Score:3)
What do you say, lets start a campaign to get the standards and measures people to make human hair an actual measurement standard.
Re: (Score:1)
It worked so well with the cubit and the foot.
Re: (Score:2)
Re: (Score:2)
Hey, I heard something similar on /. before... (Score:2)
Question (Score:3)
If this is the case, then cancer diagnostic exams should remove these cells from your blood stream, firstly.
Secondly, if you require surgery or treatment, cells in your blood stream after removal of the primary cancer should then be removed.
Which makes a lot of sense, because cancer sometimes comes back to reinfect the patient.
So this would suggest, that part of the protocols for cancer treatment would require the patient to undego some sort of immuno therapy for blood work to complete the treatment.
-Hack
Re: (Score:2)
Well, here's a thought. Say the original cancer is killed off. So far so good. But the loose cells are still cruising the bloodstream, and they're still looking for that happy-home location. Maybe it's that much easier for them to reinfect (so to speak) the original site... so the cancer "comes back". Rinse and repeat until the patient is worn out and dies.
If that's how it works, then killing off the circulating cells is just as critical as killing off the original cancer.
TRAIL (Score:2)
Re: (Score:2)
Re: (Score:1)