Bomb Blasts Alter Brain Lipid Levels 105
MTorrice writes "About 320,000 soldiers returning from the wars in Afghanistan and Iraq have struggled with neurological problems associated with traumatic brain injury, according to the Rand Corporation. Some veterans experience symptoms, such as memory loss and anxiety, without noticeable physical signs of brain injury. Now researchers report a possible chemical signature: Levels of a certain lipid spike in the brains of mice exposed to mild explosions (abstract; full article paywalled). This lipid could serve as a way to diagnose people who are at risk of developing neurological disorders after a blast, the scientists say."
Nothing to worry about (Score:2)
Re: (Score:1)
Cerebral lipid increase? Those guys are a bunch of fat heads.
Saving the American way of Life in Afghanistan. ;-)
Re: (Score:2)
Re: (Score:3)
Actually, that is arguably one of the reasons we progressed. More often then not leading thinkers and inventors who drove the progress getting us from hunter cavemen to where we are today where ones who couldn't perform optimally and compete with others. So they had to innovate to survive.
Nowadays we get Stephen Hawking and other like him, who would likely never have made it as hunters in original, genetically and morphologically same but culturally different phase of caveman hunters.
It can indeed be argued
Re: (Score:2)
Re: (Score:2)
Thats all you need to be able to sign up to the military in the first place. :P
Mind you since many US politicians are ex-military it does explain an awful lot.....
I'll admit I haven't RTFAed (Score:5, Funny)
But I imagine the researchers barely restraining their smirks after submitting a proposal to blow up mice as their study.
Re:I'll admit I haven't RTFAed (Score:5, Funny)
http://www.theonion.com/articles/worlds-scientists-admit-they-just-dont-like-mice,1256/ [theonion.com]
Re: (Score:2)
After applauding the scientists for coming forward, anthropologist Brent Wrigley suggested that the hatred of mice may be the single most important factor in the evolution of modern science.
"Despising mice may have pushed humanity out of the Stone Age," Wrigley said. "After all, the cave habitats of early man must have been infested with the horrific little monsters. The entire history of human advancement via the scientific method may be a byproduct of the higher forebrain's natural revulsion toward the nasty critters."
That would make for an interesting study in of itself. You could torture a lot of mice in the process, too.
Re: (Score:2)
But I imagine the researchers barely restraining their smirks after submitting a proposal to blow up mice as their study.
Just wait, People against Exploding Tiny Animals will be frothing at the mouth when they hear of this. It's sort of a Pavlovian reflex for them.
Have they tried lawyers? (Score:2)
The researchers are less likely to become attached to them and there are some things a mouse just won't do.
the Mythbusters are in trouble (Score:2, Funny)
Maybe Jamie, Adam, Kari and Grant can donate their brains to science to see if they show the same markers. It would make a great series finale!
Re: (Score:2)
So... you love Tory, eh?
It would be funnier if he was Tory... /. does seem like the kind of place those guys would hang out.
Re: (Score:2)
Whats that quote about unix being friendly, its just really picky about who its friends are? /.:
I donno the comparison shows some eerie similarities between MB and
1) Only about 0.1% of the population cares, if that
2) Roughly the same smart / technical / nerdy / geeky / maker-y audience
3) All the hard science and serious engineering discussion is worse than half baked
4) Endless discussion and retesting of internet memes. In fact about 50% is just endless rehashing / retesting of the same old thing
5) Tons of
I wonder if they could adapt this blood test (Score:5, Interesting)
Re: (Score:2)
Correction: it's not currently a blood test, it's:
So currently, you have to cut out the brain and slice it up to scan it. As it stands, not very helpful as a diagnostic.
I hope they can do some kind of minimally-invasive test with this. It might be possible:
Re: (Score:2)
It's possible that you could tune MRI signals to pick up a particular form of lipid. Certainly, different MRI interrogation techniques [plosone.org] can show lipid rich and lipid poor areas.
Although homogenizing football players has a certain visceral charm.
Re: (Score:3)
"Moreover, these changes were accompanied by depletion of ceramides."
What happens if you put them back?
That is, two things seem to happen. An increase in ganglioside GM2 and depletion of ceramides.
In very rough terms overproduction of something tends to work itself out if the stimulus is mitigated. That is, if a bomb was going off every day and GM2 was constantly being produced, I'd worry, but a one time increase? Let's assume that goes away over time.
The depletion of of something is more interesting I thi
Re: (Score:2)
The 'feedstocks' for the lipids and what have you are probably there (although you have to deal with the blood-brain barrier). It's the cellular mechanisms to fix the damaged areas that seem to be lacking or at least don't do such a good job. It's going to be much harder than feeding salmon to shell shocked mice.
Re: (Score:2)
" It's going to be much harder than feeding salmon to shell shocked mice."
Because you've tried this?
Or are you guessing?
I don't think mice like salmon and would probably try flax seed. Cheap and easy test to run though, no?
Re: (Score:2)
No, I have not tried to bomb the local mouse population and get back karma points by feeding them salmon. The bears would go after the salmon anyway.
My point is that feeding an organism with a blood brain barrier a building block substance is unlikely to get the chemical where and when you want it. There are hundreds of steps along the way. In addition, things like phospholipids and steroids are easily created internally and assuming the animal is reasonably well fed, giving additional precursors won't h
Re: (Score:2)
But you are correct. It's something that could be tested.
YOU go blow up the mouses. I'll watch.
Re: (Score:2)
The problem with this line of thinking is it assumes perfectly healthy 100% efficient cells.
But that's not always the case. This is why older people need to take vitamins, as we age our cells become less efficient and we have to supply a bit more. I didn't get this from the "vitamin and supplement" industry it's in the book the biochemist who discovered 2 of the B vitamins wrote.
Re: (Score:2)
Additionally there are other mechanisms. Take a dozen peaches, peel them and put them in a baggie in the freezer. Thaw them out a week later. Notice they're al brown? Now do the same thing but add vitamin C to them as anybody would who followed the recipe in the book. Now notice when you thaw them out they're the original color. That haven't oxidized.
The same thing happens in animal bodies, so it's not always the matter of supplying an essential molecule hoping a reaction will take place, sometimes you can
Re: (Score:2)
Re: (Score:2)
It is perfectly honorable and respectable to want to be trained and ready to protect your country. What is not honorable and respectable is politicians allowing unconstitutional wars.
And then we've come full circle when your politicians do that, because then it becomes honorable and respectable to not join the armed forces, lest your commitment to your country and fellow citizens be abused and misused. Except that doesn't worry or bother the politicians, since in wartime, army joins you.
Re: (Score:2)
But the politicians don't declare war if they don't see profit in it. The bigger the military, the bigger its influence on politics, and the more agressive foreign politics will become.
Probably not a good sign... (Score:5, Insightful)
Given how vital lipids are to proper brain function(cellular function generally; but nerve tissue has tons of the things even by comparison to other tissues), it seems like a very ominous sign that blast trauma too minor to cause injuries visible even with an optical microscope causes noticeable changes in the lipids floating around... Even if the neural network isn't structurally disrupted at a visible scale, interference with lipids involved in chemical or electrical nerve signalling would still cause changes in how the network functions(since the characteristics of the paths are still changing, even if connections aren't being severed outright).
Re: (Score:2)
Re: (Score:3)
I'm sure that we know less than we would like to(since invasive chemical sampling of the brain isn't really an option in humans except after death or in exceptional cases, and even in animals you can chop up whenever you want the brain is absurdly complex); but it probably helps that GM2 is also associated with Tay-Sachs disease, so at least there has been some incentive, in the form of a fairly rare but dramaticly unpleasant human disease, to explore GM2 and associated processes.
Given that there is
Re: (Score:2)
WRT vary with age, its kind of important to note the study sliced and diced at 2 hrs, 24 hrs, and 72 hrs... not like a decade later or whatever. So they did an acute study not a chronic study like most /.ers seem to assume. So... 2 hours after getting whacked in the head, you're whacked in the head... I was getting the impression from /. comments that this persisted for "a long time" but apparently not.
Re: (Score:2)
There are many types of lipids involved with the nervous system, and a wide variety of disorders associated with abnormal levels. For example, the neurological problems often seen in severe vitamin deficiencies can usually be traced to the roles vitamins play as cofactors in lipid metabolism. Problems with lipid transport and breakdown are thought to play important roles in many neurodegenerative diseases- for example, vcertain ariants of a protein involved in lipid transport called apoliprotein E are assoc
progesterone and traumatic brain injuries (Score:2)
one of the neatest recent developments in treating traumatic brain injuries is the finding that the human hormone progesterone [perfectprogesterone.com] dramatically improves the survival chances and outcomes of humans who sustain a traumatic brain injury [nytimes.com]. As someone who doesn't remember a 2-week period following a concussion/near drowning at the lake some 13 years ago, I wonder what my experience would have been like had my doctors known about this use for Progesterone USP.
Progesterone is the body's most important steroid hormone,
Re:progesterone and traumatic brain injuries (Score:5, Informative)
testosterone promotes agression in the male brain by being converted to estrogen. Women usually feel really good when they're on a progesterone-high, and only get cranky when the progesterone goes away (triggering menstruation/childbirth).
Simple psychological shock? (Score:2)
I would think most people would suffer memory loss and anxiety (among many other concomitant symptoms) after experiencing round after round of painfully loud explosions, watching their buddies get blown apart and having to kill other human beings, simply due to the unbearably intense psychological strain. Looking at it as purely a physical matter seems to be missing the point a bit. Is phys
Re: (Score:2)
I would think most people would suffer memory loss and anxiety (among many other concomitant symptoms) after experiencing round after round of painfully loud explosions, watching their buddies get blown apart and having to kill other human beings, simply due to the unbearably intense psychological strain. Looking at it as purely a physical matter seems to be missing the point a bit. Is physicality causing the mental stress, or is the causation the reverse?
What makes you think that 'psychological stress', isn't physical at it's root? Unless you are proponent of some magical soul property, there have to be physical actions within the brain that trigger what we 'feel'.
Re: (Score:2)
Because when soldiers are exposed to the same levels of stress and death but minus brain shaking explosions they don't have these kinds of problems. The guys who get blown up just aren't right in the head anymore.
They said no such thing! (Score:2)
No, the paper doesn't say that. I checked. It's also not true; this can't be used for diagnosis (except maybe post-mortem), because it's on the wrong side of the skull.
Re: (Score:2)
No, the paper doesn't say that. I checked. It's also not true; this can't be used for diagnosis (except maybe post-mortem), because it's on the wrong side of the skull.
By wrong side of the skull, I assume you mean because it's on the inside. I mean, if the lipids were on the outside, it would be obvious were the damage was. :)
Don't care much about the conclusions (Score:2)
...but damn it made me chuckle to think about spending my day in a lab "exposing rodents to minor explosions".
Hell, I pretty much did that research throughout the 6th grade. Amphibians as well.
PTSD (Score:2)
So, PTSD may be half physical brain damage?
Only brain LIPID levels? (Score:3)
Seems like a bomb blast would alter the level of everything in the brain. Of course, those levels should stabilize within a few seconds, with final values determined by the heights of the surfaces they land on.
Re: (Score:2)
That seems very likely. But it wouldn't be true for active military.
It's been done . . . (Score:2)
Bomb blasts are BAD for you? (Score:4, Funny)
Missing from this is that the brain can reset (Score:1)
One of the bizarre research results is that cooling of the brain after a concussion or explosion, can actually prevent most of this damage.
Various DARPA studies are underway.
"Sarge, Corporal Potter got an IED hit!"
"Pop an ice pack on his head and call the medic, Corporal".
Off Topic (Score:2)
Re: (Score:2)
Because it's biochemistry nor politics? Is this a trick question?
What about gunshots? (Score:2)
Is it just bombs? What if firing guns at a gun range does it too?
Anxiety leads to depression which leads to anger which leads to violence.
Could it be possible that shooting guns recreationally messes up the biochemistry of peoples heads with any number of negative possible outcomes?
Don't tell the NRA (Score:2)
Now researchers report a possible chemical signature: Levels of a certain lipid spike in the brains of mice exposed to mild explosions
Maybe mild explosions like one experiences from the repeated firing of assualt style rifles inches from one's skull while using extend capacity clips?
TBI and MRI (Score:2)
TFA discusses traumatic brain injury (TBI), which reminded me of another FA that I read a while ago about detecting TBI with MRI machines.
Two guys, Dr. Walter Schneider and Dr. David Onkonwo, are using MRI to identify neural tracts throughout the brain. Their new technique, HDFT, is able to visualize the brain's wiring, and it can identify where the wiring has been broken.
http://www.cbsnews.com/8301-504763_162-57389325-10391704/new-technology-could-change-how-traumatic-brain-injuries-are-diagnosed/ [cbsnews.com]
Only 99 Years (Score:2)
So it has only taken 99 years to come up with an explanation for what was bleeding obvious since WWI. Shell shock is nothing new.
lipid test to renew .... (Score:1)
drivers license.
purchase condoms
obtain a marriage license.
obtain a passport
obtain entrance to the no fly list.
and more ....
Re: (Score:1)
Re: (Score:1)
If you are so fucked up that you can't recognize that countries need militaries then perhaps you should go live in Somalia.
If you think that you are better than those who willingly serve then I propose that you do the world a favor and completely remove yourself from society.
Re: (Score:2)
Countries only need militaries because other countries need militaries. Perfect chain of iterated circular logic.
If you think that you are better than those who willingly serve then I propose that you do the world a favor and completely remove yourself from society.
I've never killed a man because some greybac... er... hair handed me a gun, mailed me to a faraway desert, and to
Re: (Score:2)
Countries only need militaries because other countries need militaries. Perfect chain of iterated circular logic.
Unfortunately so. No one will disarm until everyone disarms, until everyone disarms it would be criminally negligent to disarm.
I've never killed a man because some greybac... er... hair handed me a gun, mailed me to a faraway desert, and told me to hate the people I found there. Living nicely with my conscience in that regard, thanks. You?
I haven't either but I am not going to insult those who do put themselves in that position and I am not going to think that I am better than them just because I am not willing to put my life on the line for my country. That would be foolish.
Re: (Score:1)
Re: (Score:2)
Lets say for the sake of argument that the United States did not have a military, for whatever reason we decided that the world loves us enough that no one would ever think of causing us harm.
But Mexico has a military, and they aren't doing quite as well as the US so they decide to invade because they think if they steal stuff from the US that it will make their situation better. Read up on history and you will find this has in fact happened many times and is the reason that some of the great societies wer
Re: (Score:2)
"I have a purpose in life"
Trolling slashdot?
Re: (Score:2)
Re: (Score:2)
Sure sounds like trolling. Especially the "I know I'm better" part.
(I'm more amused than anything else, as it reminded me of a scene in the movie Mulholland Falls where someone is saying "I'm better than you!" just before he gets tossed out of an airplane. Ironically, in this case, it was a military type saying it.)
Re: (Score:2)
I don't think I'm better then those who willingly serve, I know I'm.
If you want to willingly serve go ahead but don't complain at all if you get hurt and don't let you family complain if you get killed, that's what you accept happening by going into the military, hence you want to get hurt and that to me sounds like serious mental illness, not rational.
Re: (Score:2)
The vast majority of them don't complain at all. They do their service and move on with their life.
Some of my co-workers, friends, and family are ex-military, they don't sit around bitching about what they signed up for, they just go about their lives. That is harder for some than others due to PTSD issues, but I haven't heard a word of regret about their service.
Re: (Score:2)
I doubt that you know what "the country" wants to do with it's military. You've obviously never been in one. I can only speak for the US Army but they do a good job taking care of their own. There are piles of support programs for soldiers to take advantage of (including education).
I can promise you that any government that treats its soldiers like gum on their shoe will not last a single night against a real army.
Re: (Score:2)
Re: (Score:2)
As far as i can tell, mainstream media is a civilian/private thing, not a government one. Don't blame the government that you don't hear about soldiers in the news. Also, there is such a thing as middle ground. Not remotely giving a care in the world and treating them like the Queen of England are at opposite ends of the spectrum. Instead of pushing your idea of how you think the government treats it's soldiers, you should ask some soldiers.
It's okay to not support wars, soldiers, or any military. In m
Re: (Score:2)
Re: (Score:2)
So if a country is attacked by another country the country that is defending itself is not allowed to use lethal force?
You have officially confirmed that you do not use your brain at all.
Please leave society and take your DNA with you.
Re: (Score:2)
Re: (Score:2)
Do you blame the Aztecs for getting slaughtered by the Spanish?
Did they go out of their way to piss off the Spanish? Or did the reason the Aztecs got conquered have nothing to do with what they did, but instead have everything to do with the Spanish?
Re: (Score:2)
Re: (Score:2)
The words you use do complete a sentence, but I am unsure on how they relate to the topic at hand.
Re: (Score:2)
Re: (Score:2)
I think I know where you are trying to go, and you are of course still wrong, and you will continue to be wrong. You are so wrong in fact that I have to question if you are really stupid enough to make the argument you are trying to make.
So since it is literally impossible that there is a section of the Earth with an unknown indigenous population lets say that the Moon is inhabited by nice peaceful folks, if we go and kill them, was it their fault?
You blame the victims of violence and war just as much as y
Re: (Score:2)
If I'm not willing to project how I feel then I either don't feel that way or I don't know how I feel, in either case I wouldn't have a point. When someone can show me a war where no one dies ( without using Star Trek ), then I'll finally support the military, until then I see the military and war as nothing but a mass killing.
I'm pretty sure I know how I feel about the argument you are trying to make and yet I choose not to project it.