An anonymous reader tips news that researchers have successfully demonstrated particle-wave duality in molecules that have masses of 514 and 1,298 atomic mass units. The academic paper can be found in Nature Nanotechnology. "Thomas Juffmann et al. fired molecules composed of over 100 atoms at a barrier with openings designed to minimize molecular interactions, and observed the build-up of an interference pattern. The experiment approaches the regime where macroscopic and quantum physics overlap, offering a possible way to study the transition that has frustrated many scientists for decades. ... The relatively large phthalocyanine (C32H18N8) and derivative molecules (C48H26F24N8O8) have more mass than anything in which quantum interference has previously been observed. To have wavelengths that are relatively large compared to their sizes, the molecules need to move very slowly. Juffmann et al. achieved this by directing a blue diode laser onto a very thin film of molecules in a vacuum chamber, effectively boiling off individual molecules directly under the beam while leaving the rest unaffected. ... The researchers observed the particle nature of the molecules in the form of individual light spots appearing singly in the fluorescent detector as they arrived. But, over time, these spots formed an interference pattern due to the molecules' wavelike character.'"