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Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome In Mice 63

An anonymous reader writes "New research by a team of Bangalore-based scientists has given hope to those with emotional problems caused by the inheritance of a fragile X chromosome. The researchers, for the first time in the world, mapped defective connections between nerve cells in the emotional hub of the brain of mice who had Fragile X Syndrome. The research has just been published in the online edition of the US-based Proceedings of the National Academy of Sciences." Besides the mapping of these nerves, though, "The NCBS team has shown that even the long-term ravages of the condition could be reversed with medication in mice." Fragile X syndrome is associated with autism, though the conditions do not map directly to each other.
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Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome In Mice

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  • by Saeed al-Sahaf ( 665390 ) on Saturday June 12, 2010 @03:35PM (#32551800) Homepage
    There has to be some way to tie an Indian Call Center Joke into this...
  • What? (Score:5, Insightful)

    by XnavxeMiyyep ( 782119 ) on Saturday June 12, 2010 @03:36PM (#32551802)

    Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome


    • Re: (Score:3, Insightful)

      by X0563511 ( 793323 )

      That is a really -bad- headline.

      Removing two whole words would fix it too (words that aren't really required in the headline)
      Doctors Reverse Autism-Linked Fragile X Syndrome In Mice

      Really now... how they did it doesn't need to be in the headline.

      • Re: (Score:3, Insightful)

        by lgw ( 121541 )

        These days, headlines aren't for reading by humans, but by search engines. If "Autism drugs" is a trending search, it's a perfect headline - the words are even adjacent. It's the sad modern word of news.

    • Re: (Score:3, Insightful)

      It's greatest as what you do can possible! Sense is perfect making!
    • by nashv ( 1479253 )
      Complain not , of the headline shall you. Strong is the force, cured the furry ones are.
    • by Jorkapp ( 684095 )

      Has anyone really been far even as decided to use even go want to do look more like?

    • Re:What? (Score:4, Funny)

      by XCondE ( 615309 ) on Saturday June 12, 2010 @06:29PM (#32552884) Homepage

      Doctors Reverse With Drugs Autism-Linked Fragile X Syndrome


      Editors are sick of people not reading the summary so they're making the headline incomprehensible. Your move.

    • It's with a machine from German translated think I.

  • Headline...? (Score:2, Insightful)

    What the hell is with that headline?
  • Up to 20% of boys with autism have the condition due to Fragile X.

    In other words, at least 80% of individuals with autism need to find hope for a cure somewhere else.

    • by Saeed al-Sahaf ( 665390 ) on Saturday June 12, 2010 @03:53PM (#32551932) Homepage

      In other words, at least 80% of individuals with autism need to find hope for a cure somewhere else.

      20% is an insignificant number? Not if your child has Autism. And suppose you had Cancer, would you pass on looking into a treatment because it "ONLY" had a 20% rate of potential improvement?

      Hoestly, what is your point?

    • Many autistics don't want a cure, they would probably welcome getting some of the obnoxious symptoms under control, but for many Autistics, being cured of autism would be like Negroes being cured of negroism!

  • 1. Aparna Suvrathan a,
    2. Charles A. Hoeffer b,
    3. Helen Wong b,
    4. Eric Klann b, and
    5. Sumantra Chattarji a,1

    - Author Affiliations
    a National Centre for Biological Sciences, Bangalore 560065, India; and
    b Center for Neural Science, New York University, New York, NY 10003

    These are lab findings in cells of knock out mice and indicate that

  • by Trixter ( 9555 ) on Saturday June 12, 2010 @03:59PM (#32551976) Homepage

    The symptoms are similar but they are only tangentially related. The headline is incredibly misleading by suggesting a drug has been produced that can reverse autism, which is of course not true.

  • Try June 25, 2007
  • Both the /. and original news headline claim that scientists have found a way to "reverse" the fragile-x syndrome, but the study simply says that they have "mapped" the defective connections. That doesn't mean they know how to fix them yet...
  • by PatPending ( 953482 ) on Saturday June 12, 2010 @04:21PM (#32552100)

    From June 27, 2007:

    Autism Reversed in Mice at MIT Lab []

  • Sweet. (Score:4, Interesting)

    by DWMorse ( 1816016 ) on Saturday June 12, 2010 @04:45PM (#32552236) Homepage

    My oldest son has Fragile X and is diagnosed in the Autism spectrum. It's an incredibly impairing disability, and I'll be asking his doctor to keep on eye on the clinical trials.

    On a side note, as well voiced thus far, what headline is the hell up with what is there? For cryin' out loud.

  • by DynaSoar ( 714234 ) on Saturday June 12, 2010 @05:50PM (#32552662) Journal

    They supposedly mapped the connections involved.

    They previously determined what enzyme caused the damage and found something to inhibit it.

    They *assert* that they could possibly reverse the damage using this inhibiting enzyme. COULD.

    Inhibiting damage can prevent. You cannot inhibit damage already done. Inhibition and reversal are not the same. Nor are the two syndromes involved.

    Times of India ranks up there with Pravda when it comes to truthful accuracy, especially when it comes to home ground science. The "for the first time" gets read as though nobody had ever done this mapping before. It could as easily mean it was the first time they did it. It has been done before.

    The asserted reversal has also been done before. Not by them or by their New York friends, but at MIT.

    • by nashv ( 1479253 )
      I am not surprised. As an Indian and a biologist, and having been involved with NCBS at some time , I have to unfortunately admit that NCBS has a tendency to toot its horn louder than it has earned the right to. The Indian press for that matter, for the lack of bleeding edge Indian-origin science stories, sucks up NCBS's blaring trumpets like it was Mozart's unknown masterpiece every time.
  • I read the wiki article. Epistemology, thus neuroscience, is a main area of interest for me. I'm very reticent about jumping on the band wagon for stuff like this just because what we call mind and behaviour is very complex. The American biologist, Gregory Bateson [] wrote a couple of wonderful, thought provoking books, 'Steps to an Ecology of the Mind', and, 'Mind and Nature'. In 'Mind and Nature' Bateson referenced an idea made famous by A. Korzybski [] that Bateson put as, "The Map Is Not The Territory, And Th

  • However, The Lancet just published a study by a well-known British surgeon which found these drugs frequently caused MMR.
    • I'm aware of a study that was retracted by the Lancet, authored by a gastroenterologist who had his license to practise medicine revoked that talked mentioned MMR, is that the one?

  • I guess it didn't work on the guy who wrote the headline.

"How many teamsters does it take to screw in a light bulb?" "FIFTEEN!! YOU GOT A PROBLEM WITH THAT?"