8% of Your DNA Comes From a Virus 478
An anonymous reader writes "About 8 percent of human genetic material comes from a virus and not from our ancestors, according to an article by University of Texas at Arlington biology professor Cédric Feschotte, published in the Jan. 7, 2010 issue of Nature magazine."
Re:Ob. Matrix quote (Score:2, Informative)
Summary and article misleading (Score:3, Informative)
These are endogenous virus fragments. Which means that a virus inserted itself into your ancestor's DNA. So you didn't get this new DNA after you were born, you inherited the 8% viral DNA from your ancestors.
What a crappy press release (Score:2, Informative)
So 8% of my DNA comes from a virus and not from my ancestors? I guess that means that I was infected with the DNA after conception and for some reason it's not heritable since I didn't get any from my ancestors. The big story, then, is that there is a mechanism that excludes the viral DNA during meiosis.
Dr Feschotte must have cringed when he read the release.
the OA refed in the OP link is in N&V section (Score:4, Informative)
http://www.nature.com/nature/journal/v463/n7277/full/463039a.html [nature.com]
That section is mostly commissioned and if not submissions reviewed by editor (technically, not peer reviewed).
The author of the referred N&V article is the author one of the articles in the reference section...
For peer-reviewed article, I would go for:
http://www.nature.com/nature/journal/v463/n7277/full/nature08695.html [nature.com]
written by bunch of Japanese:
Endogenous non-retroviral RNA virus elements in mammalian genomes
Re:Bible Code? (Score:5, Informative)
Re:Not Bad (Score:2, Informative)
Sickle cell anemia originated as a mutation. The mutation happens to confer some defense against malaria, so it became widespread in certain geographic areas and is still present in the population.
That's a small difference in phrasing, but it is much clearer.
Re:Bible Code? (Score:2, Informative)
"Any sufficiently large set of information is going to give you some matches on just about anything you search for."
That's why the bioinformatics tool the Japanese (authors of the original paper in Nature) were using (called BLAST) has a parameter called an e-value for each sequence similarity hit. It's basically a probability to encounter such hit randomly in a database of that size (assuming the sequences in the database are pseudo-randomly distributed).
That evalue for the found matches is less than 1e-70.
HERVs are ancestral (Score:2, Informative)
The posted summary is somewhat misleading. Human endogenous retroviruses (HERVs) are responsible for ~8% of the human genome sequence, but these things haven't been active for a long time in terms of human history - so the 8% that's in your genome now did come from your parents, and their parents etc. until you get back to the time many thousands of years ago when HERVs were actively creating new insertions. The linked summary is a summary of a new finding in which the 'endogenization' of a new class of virus known as a Bornavirus is reported (which exists in only a few copies in humans)
Re:Bible Code? (Score:3, Informative)
Your genome can tolerate a significant insertion of genes, as long as they don't cause serious trouble. In terms of viral DNA additions, the most significant risk is for a stretch of viral DNA to insert within an existing gene, breaking it and possibly creating a new gene variant that causes harm. This is believed to be a mechanism of viral infections associated with cancers (e.g. Epstein-Barr and Hodgkin's lymphoma, HPV and cervical cancer).
Misleading title (Score:3, Informative)
The "8% of your genome" comes from the first paragraph of the News and Views article which reviews the actual article by Horie et al, and is referring to ALL viral remnants in the human genome, not just this new Bornavirus one. From a quick scan of the paper, it looks like they didn't estimate what fraction of the human genome comes from their Bornavirus, but they only describe 4 actual elements - so that's a vanishingly small part of the human genome. The vast majority of viral elements in the genome come from retroviruses and other retrotransposons, and that's been known for a long time.
Research was conducted by Keizo Tomonaga in Japan (Score:2, Informative)
From the article the research was "led by Professor Keizo Tomonaga at Osaka University in Japan". The article that Cedric wrote was just an opinion piece discussing the research by Dr. Tomonaga.
Re:Not Bad (Score:4, Informative)
Unless it occurred recently and you're an intermediary state between mutation occurring and the mutation dying out.
Our modern civilization though protects the well being of even those with negative traits who would have otherwise naturally died out. That's not to say evolution in humans has stopped. Instead, we're simply not weeding out the negative traits.
Re:Ob. Matrix quote (Score:1, Informative)
Ahhh religion, where changing flesh into bread and blood into wine isnt considered "witchcraft". Yet all other "magics" was at one time punishable. Hypocrisy, it loves religion.
While there are some individuals who do believe that the bread and wine become flesh and blood upon consumption, that is a very uncommon view. Instead, the act of communion is period of remembrance of what Jesus Christ sacrificed to cover our sins. His body was tortured as payment for those sins, and his blood was shed to cover those sins. A bit confusing, I understand, especially if you have had no experience with it. But, communion is not what you are making it out to be.
Re:Useful? (Score:3, Informative)
In fact, back when lasers were first invented, people referred to them as "a solution looking for a problem". They were so cool, but for a while nobody could think of anything useful to do with them.
Re:Ob. Matrix quote (Score:3, Informative)
Is Teller God? Should I worship him?
Why don't you ask him yourself?
Because he wouldn't answer you.
Re:Ob. Matrix quote (Score:5, Informative)
Re:Ob. Matrix quote (Score:3, Informative)
Re:Useful? (Score:4, Informative)
I remember reading an article about sheep and virii. Some type of sheep use to have a virus that use to be bad for it. Even though this virus was bad, it did have one good attribute. It reduced the chance of a miscarriage and did it better than another "native" gene.
It so happened that this viral infection reduced the chances of miscarriages enough that at some point the virus stopped being bad for the sheep and they had a better chance to reproduce.
Now days, if you neutralize the virus, the sheep will always miscarry since the old gene got silenced/removed in favor for the virus.
The sheep and virus evolved to live together.
I read this a LONG time ago, i think it was in Discovery mag or something, but I can't remember much more than the idea of the story. The details might be slightly off, but the summary is the same. And they did talk as if the virus was still actually living in the host, not just select genes.
Re:Ob. Matrix quote (Score:3, Informative)
Re:Not Bad (Score:3, Informative)
If my ancestor got a brain virus, and it is still with us, then it most probably is that that virus provided something very positive compared to the negatives that you speak of.
No. All it means is that whatever changes the virus makes, it doesn't greatly affect the ability (means and opportunity) of those who have it to reproduce. Remember, natural selection, the mechanism through which evolution operates, is not working toward a glorious future of perfection, it is a consequence of how adapted an organism is to its environment. If the organism can reproduce just as much with the virus as without, then it's going to stick around even if all it does is sometimes cause schizophrenia and provides no positive traits.
Re:Useful? (Score:3, Informative)
Re:Who owns the copyright? (Score:3, Informative)
So if you're looking at a chunk of DNA and it appears to be continuous, particularly continuous and overlapping, it's very likely recently viral, while if it has big chunks of other stuff in it, long promotion/repression sequences, lots of regulatory stuff, it's probably not recently viral. Does that answer what you're wondering?
Re:Useful? (Score:3, Informative)
Re:Ob. Matrix quote (Score:3, Informative)
On top of all that, the fact that "The Flood" actually has even earlier recorded sources (Sumerian, for example) just make the whole thing even more, well not maybe comical, but at least mildly amusing.
Yes, amazingly almost every culture on earth has a global flood story with a single boat, a bunch of animals and a negotiation of sorts with a god or gods. There are over 200 of them, involving nearly every culture that was on earth in early history.
For instance, this one from China, where the person is even named Ndrao-Ya.
http://www.archives.ecs.soton.ac.uk/miao/songs/TranslatedSongs/m131/m131tr.pdf [soton.ac.uk]
Here's a handy chart to summarize the similarities:
http://www.answersingenesis.org/articles/am/v2/n2/flood-legends [answersingenesis.org]