Cancer Vaccine That Mimics Lymph Node 53
SubComdTaco writes "Harvard has announced their approach towards an implantable cancer vaccine (press release here). To anyone familiar with how the immune system works, this appears to be a synthetic lymph node, an intriguing bit of biomimicry. From the Science Daily article: 'A cancer vaccine carried into the body on a carefully engineered, fingernail-sized implant is the first to successfully eliminate tumors in mammals, scientists recently reported in the journal Science Translational Medicine. The new approach, pioneered by bioengineers and immunologists at Harvard University, uses plastic disks impregnated with tumor-specific antigens and implanted under the skin to reprogram the mammalian immune system to attack tumors. The new paper describes the use of such implants to eradicate melanoma tumors in mice. ... The slender implants... are 8.5 millimeters in diameter and made of an FDA-approved biodegradable polymer. Ninety percent air, the disks are highly permeable to immune cells and release cytokines, powerful recruiters of immune-system messengers called dendritic cells. These cells enter an implant's pores, where they are exposed to antigens specific to the type of tumor being targeted. The dendritic cells then report to nearby lymph nodes, where they direct the immune system's T cells to hunt down and kill tumor cells.'"
interesting (Score:1, Interesting)
hmm could this be used for HIV as well then? program the immune system to attack it?
Re:interesting (Score:4, Informative)
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The larger problem is that the AIDS virus does not copy itself particularly well, consequently mutating fast. Different 'populations' of slightly different versions of the AIDS virus grow and decline and eventually the immune system can never quite rid the body of the infection which eventually overwhelmed as you described.
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Not a cure for cancer, a possible way to treat tumors. Theres plenty of types of cancer that wouldn't do shit for, and a heavy immune response wouldn't be very good for the brain if that other new research claiming to cure many MS cases is to be believed(http://en.wikipedia.org/wiki/Blood-brain_barrier#Multiple_sclerosis_.28MS.29).
8.5 millimeters .. (Score:5, Insightful)
If it cures my cancer, I don't care if the think is the size of a hockey puck and they have to stick it in my forehead*.
*Ass was too expected.
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Which has nothing to do with my post, well done, well done getting your typical knee jerk response out of the way early.
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Score: 5, Sarcastic?
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Very interesting (Score:1)
A fantastic breakthrough if it works, though. I have been hearing about potential strategies to enable a cancer victim's own immune system to attack tumors, but this is the furthest along that I've heard of. Good jorb!
Really cool... (Score:3, Interesting)
unless the foreign components are later found to cause cancer themselves.
Re:Really cool... (Score:5, Insightful)
depends, if it cures your cancer now, but it will give you cancer in 20 years it may be worth it.
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Most cancer treatments actually increase your chances of other cancers. (Chemo/radiation).
Pretty much the only treatment that isn't known to increase the risk for secondary cancers is surgery and that is usually followed by frequent x-rays or CT scans (which are known to increase chances of secondary cancers)
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unless the foreign components are later found to cause cancer themselves.
Or vampirism. [wikipedia.org]
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Ah, but does it give you autism?
Just kidding. I find those people irresponsible and ignorant.
Treatment, not vaccine... (Score:2)
Re:Treatment, not vaccine... (Score:5, Insightful)
it's a therapeutic vaccine.
http://en.wikipedia.org/wiki/Vaccine [wikipedia.org]
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Rats - somebody beat me to it :^\
Not a immunologist (Score:2)
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Cancer is triggered by the mutation of a normal cell into one that basically reproduces indefinitely. The worst types of cancer (e.g. small cell carcinoma) are cells that are smaller than normal cells, and these are particularly dangerous because they don't clump together like benign tumors. These ones spread throughout the body and that is why they are so deadly. I'm not quite sure why the body doesn't recognize these cells as "invaders" in the first place. But, if they can synthetically tell the lymph
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I'm not quite sure why the body doesn't recognize these cells as "invaders" in the first place.
I'm not an immunologist, but I would guess it's because the cancer cells don't cause violent death (necrosis) of normal cells.
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Its actually in line with a more common cancer treatment (that some oncologists believe may have a lot of promise) that was used prior to the discovery of x-rays and other forms of radiation... back in the early 20th century, a common treatment was the injection of infectious fluid (bacteria basically) into the tumor, which (we know today, they didn't then) caused the body's immune system to go into overdrive and as a side effect take out the tumor as well.
Radiation became the norm in the 30's and 40's (whe
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It does seem that this is a refinement on that very old technique. It has the advantage that it doesn't require a solid tumor mass to work, so it can be tried after the current treatments to clean up that last bit that can cause a relapse.
Once it's proven itself there it will likely be tried as a replacement for radiation/chemo.
Step right up (Score:1)
As someone diagnosed with colon cancer (Score:2)
Auto-immune (Score:1)
I would be worried about invoking autoimmune diseases.
Human clinical trials (Score:3, Informative)
Making the immune system attack (only) the cancerous cells seems to be a popular research subject these days.
Another company called Immunovative is taking a slightly different approach which does not require an implant.
They are currently running human clinical trials in Israel and California. More information here [immunocare.net].
Disclaimer: A close friend of mine is participating in the clinical trial in Carlsbad.
Zamboni cured MS anyone anyone? (Score:1)
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Here for MS treatment approach:
http://www.theglobeandmail.com/news/national/researchers-labour-of-love-leads-to-breakthrough-in-treating-ms/article1372414/ [theglobeandmail.com]
Any recent information? (Score:2)
not first (Score:1)