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Medicine Biotech Science

Nanoparticle Infused Gauze Quickly Stanches Wounds 155

jackieduvall writes "Medical gauze has received its first upgrade since World War I. Chemists have infused it with nanoparticles derived from kaolin clay, which somehow give it an amazing ability to stop severe bleeding. It was developed when the Navy approached a team of inorganic chemists at the University of California Santa Barbara to solve a problem with QuikClot, a zeolite-based hemostatic agent that became way too hot and caused burns when it came in contact with water or blood. While performing blood clotting tests, they realized that kaolin clay, which has been used as a control for clotting experiments since the 1950s, could also be used as a first aid product." There is a video demonstration alongside the article. It shows the gauze halting the bleeding from a pig's aorta. The blood isn't excessive, but if you're bothered by that sort of thing, you may want to skip the video.
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Nanoparticle Infused Gauze Quickly Stanches Wounds

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  • by Anonymous Coward on Friday April 25, 2008 @04:48PM (#23203242)
    • by Mursk ( 928595 ) on Friday April 25, 2008 @04:52PM (#23203282)
      I think the difference is that this gauze can be used fairly easily and quickly by just about anyone. The gel mentioned in the linked article seems like it would be more for operative use by surgeons (the summary mentions eye surgery). They are somewhat similar, but this still seems to represent something "new."
      • Ah... I seem to remember another one as well.

        Instead of using shrimp particles, they want to be politically correct and use nanoparticles.

        http://science.slashdot.org/article.pl?sid=05/07/16/1518208 [slashdot.org]
        • by Mursk ( 928595 )
          Ah... OK, you win that one. Without actually reading either of the full articles, that does sound pretty similar...
      • by SoyChemist ( 1015349 ) on Friday April 25, 2008 @04:58PM (#23203334) Homepage
        Yeah, there are also surgical gels made from a polymer which is structurally similar to a protein from mussels.
      • by bargainsale ( 1038112 ) on Friday April 25, 2008 @05:24PM (#23203520)
        I am an eye surgeon [IAAES?], and I find it hard follow why Dmitri Azar in the linked article thinks it would be so useful in our field.

        Bleeding isn't normally a big feature of eye surgery such as cataract surgery.

        Maybe he has applications in retinal surgery in mind. Blood in the vitreous humour inside the eye clears away very slowly, and sometimes needs to be removed surgically, which is a very major eye operation. It would be good to have some substance you could inject into the eye which would clear the blood faster: in fact various things of this kind have been tried.

        It doesn't seem that this stuff would be particularly useful in that way, as it arrests bleeding rather than clears blood.

        Neurosurgery I can see, though.
        It reminds me of when I did neurosurgery as a trainee, years ago; brain bleeds easily, and the more you touch it, the more it tends to bleed. We used to splosh peroxide on the bleeding spots to arrest bleeding (I don't know if this still goes on).
        I remember a cynical anaesthesiologist saying he was convinced that peroxide had no actual effect in itself to stop the bleeding - what happens is that the peroxide fizzes for several minutes and during that time the surgeon has to keep his fingers away from the brain, and it's THAT that arrests the bleeding.
        • Heh I just had to prematurely end my dinner--that will teach me to read IAA*S posts while eating!
        • the peroxide fizzes for several minutes and during that time the surgeon has to keep his fingers away from the brain, and it's THAT that arrests the bleeding.
          seems easy enough to test. Replace the peroxide with Folgers crystals and see if he notices.
        • Re: (Score:2, Funny)

          Wow. Never thought I'd hear words like 'neurosurgery' and 'splosh' in the same paragraph. Remind me never to let you cut open my skull. ;-)
      • by Ihmhi ( 1206036 )

        Yeah, this is the sort of thing you would want to issue to Soldiers to slap over a bullet wound on their thigh while they wait for the Medic to get to them. Every second counts when you're losing blood.

        I think they're already carrying a bandage that slows blood loss, but nothing that stops it like this does. This could save a lot of lives in combat. Hell, I'd put some under the seat of my car in case I ever got into a wreck. :3

  • by Anonymous Coward on Friday April 25, 2008 @04:53PM (#23203288)
    It doesn't say what happened to the pig. I have to hope there was a BBQ afterward.
  • So when our ancestors got wounds and rubbed dirt into them they had it right all along? Or is it they had it wrong, you only rub special dirt in, and only if the wound is severe?
  • Sounds (Score:5, Funny)

    by Kamineko ( 851857 ) on Friday April 25, 2008 @05:13PM (#23203460)
    Sounds like a gauze for celebration!
  • by neapolitan ( 1100101 ) * on Friday April 25, 2008 @05:13PM (#23203462)
    Medical factoid - kaolin and pectin are the substances that constitute the anti-diarrheal substance "Kaopectate" (hence the name.) Note that it doesn't really do anything but bind with water -- kind of a clay-like substance that will then give one more firm stools.

    I think the modern kaopectate has modified its ingredients, but kaolin clay like substances are still available for medical use. Nice to see a new implementation of this technology, with the "nano" prefix thrown in for sexiness.
    • by SoupGuru ( 723634 ) on Friday April 25, 2008 @05:36PM (#23203614)
      I wish my wife thought "nano" things are sexy.
      • She does. Unfortunately, she doesn't think of it as a prefix, but as something that follows "iPod".
    • Nice to see a new implementation of this technology, with the "nano" prefix thrown in for sexiness.
      Yea, I was rather disappointed in what I read from TFA.

      They had this new whizbang clotting agent, but it was very exothermic, so....
      Their solution was to take a old, known clotting agent and grind it up really fine.
      The End.

      How anticlimactic.
    • by Tokerat ( 150341 )
      When I read the title of your post, I thought they where going to start making gauze underwear. Nothing quite like that "Imhotep" look to help protect yourself against the Colorado quick-step...
  • Ah... (Score:5, Funny)

    by jd ( 1658 ) <imipakNO@SPAMyahoo.com> on Friday April 25, 2008 @05:16PM (#23203478) Homepage Journal
    That's fine for people with blood, but what happens to those of us who are caffeine-based lifeforms?
    • Re: (Score:3, Funny)

      by spun ( 1352 )
      Just use powdered non-dairy creamer, silly.
    • by ameline ( 771895 )
      Or alcohol based ones for that matter...
      Or hybrids (I currently have coffee and baileys flowing through my circulatory system :-)

  • by the Dragonweaver ( 460267 ) on Friday April 25, 2008 @05:24PM (#23203516) Homepage
    Clay- all clay- is basically a mixture of kaolin, water, and larger particles (sand or "grog"- crushed clay bits.) Clays with a low percentage of kaolin and a high percentage of inclusions are low-fire clays, such as terra cotta, while a high percentage of kaolin is necessary for high-fire clays such as porcelin.

    Porcelin clays are fired between three and four thousand degrees in order to vitrify- which means, to melt and fuse together. Glazes, which are based in sand and metal, vitrify at a lower temperature, which is why pots have two firings, the first to make them pots instead of shaped clay, and the second to decorate them.

    Kaolin is not quite as common as dirt or sand but it is found all over the world and not too difficult to obtain. A good college ceramics department will have a barrel on hand.

    The upshot of this, I guess, is that if you are foolish enough to stick your hand into a clay mixer, which is like a Kitchen Aid stand mixer on steroids, and get your hand torn off, sticking your hand into the barrel of kaolin dust would be amazingly good first aid.
  • The blood isn't excessive, but if you're bothered by that sort of thing, you may want to skip the video.

    Here's something that I've always wondered and never got an answer to. Why are some people bothered by the sight of blood? What's shocking about it? I really don't get it even a bit. Besides I always thought (my own) blood was kind of yummy.

    • Re: (Score:3, Insightful)

      by jheath314 ( 916607 )
      I suppose it has something to do with our natural aversion as a species to injury and death. Most apes aren't really predators by nature (many are omnivorous, but mostly vegetarian), so usually any blood they happen to see would be their own.
      • by 4D6963 ( 933028 )

        That's fine and dandy, but that doesn't tell me what people who are bothered even slightly by the sight of blood feel or think.

        • It's a matter of conditioning and mindset. I've seen people blow chunks when they catch the smell of spoiled casein paint, but because I know what it is and I have acclimated to it, I am no longer bothered by the smell. It makes sense to instinctually associate blood with violence and death (and thus be revolted) unless you have learned other associations with it. Most trauma injuries make me think of mountain biking.
    • by Nullav ( 1053766 )
      I'd assume it has more to do with seeing it come out of something; sort of how many of us will pass on touring a slaughter house but fry up strips of bacon first thing in the morning.
      Reinforcing my point: I've never seen anyone vomit at the sight of maroon paint.

      Besides I always thought (my own) blood was kind of yummy.

      I somehow doubt your first reaction to losing a hand would be to grab a dixie cup.

      Somewhat off-topic: Am I the only one having trouble loading the video? I just see a black rectangle with a menu below.

    • Re: (Score:3, Funny)

      by couchslug ( 175151 )
      "Here's something that I've always wondered and never got an answer to. Why are some people bothered by the sight of blood?"

      Social conditioning. When I was young I was tasked with beheading and plucking a bunch of chickens. I found it a bit nasty (I was an innocent suburban kid) because I was never taught nor had I experienced anything different.

      My views changed instantly on eating the delicious stew made from my victims. :)
    • I get areas of nasty dried skin on my feet and will happily set about cutting them off. Inevitably I cut too deep and bleed a little. Everywhere. First time I thought "oh crap"... but 100th or so time performing minor surgery, I don't give a shit.

      Mind you, despite 3 years practise the missus still gets in a tizz as I sit stemming the bleed with tissue paper and/or superglue. Mostly because I'm making a mess on the carpet (I don't want to think about the row I'd get if I bled to death on the nice rugs).
      • by JerkBoB ( 7130 )
        I get areas of nasty dried skin on my feet and will happily set about cutting them off.

        Jeezus. First of all, that's called a callus [wikipedia.org]. Second of all, why the hell are you cutting them off? Just use a pumice [wikipedia.org] stone to abrade them off. No blood, you can do it in the shower. No muss, no fuss.

        Finally, unless you're a girly-man, you WANT calluses. They let the chicks know you're tough. Or something. Alright, calluses on feet are gross.
    • when I took the Combat Life Saver course, one of the requirements for graduation was to start an IV, and of course this implied that somebody was need to have the IV started one and it doesn't take much imagination to figure out "each other" was nominated. One of my fellow students confided to me "Sargent I'm afraid of needles" so I figured no problem, I got two arms, and getting stuck twice isn't a big deal. It turned out that when he said "afraid of needles" I heard "afraid of have a needle inserted into
    • Here's something that I've always wondered and never got an answer to. Why are some people bothered by the sight of blood? What's shocking about it?
      Dunno, but I can't watch surgery video. In Afghanistan I had hands-on experience with everything from sucking chest wounds to burned and blown-up bodies. I can hold a big ol' gaping wound shut with a pressure dressing in real life, but I can't stand to watch open heart surgery on the Discovery Channel. Mysteries of the universe.
  • by kdubb1 ( 930778 ) on Friday April 25, 2008 @05:27PM (#23203548)

    "In 2002, following the September 11 attacks, the military was looking at new technologies to stop bleeding," Huey says.

    As if the military had no other reason to look into this.
    • If we are prevented from using cheesy pretexts in the post September 11th world, the terrorists win.
  • nano technology? (Score:2, Interesting)

    by icebike ( 68054 )
    Since when does grinding something small constitute nanotechnology?

    I'd have to take such characterization with a grain of nano calcium chloride.
    • by Dahamma ( 304068 )
      Since when does grinding something small constitute nanotechnology?

      Why mod this "interesting"?

      There was no mention of "nanotechnology" anywhere in the article or summary. They are talking about nanoparticles.

      Quoted from your local neighborhood Wikipedia:

      "A nanoparticle which historically has included nanopowder, nanocluster, and nanocrystal is a small particle with at least one dimension less than 100 nm."

      See, no tiny machines necessary...
    • Since when does grinding something small constitute nanotechnology?
      Since we got measuring and grinding technology capable of nano-scale work?
    • Maybe.

      I use a product called Surround (tm) that is finely ground kaolin to keep bugs off plants like apple trees and roses. Word is that some apple farmers used regular kaolin that wasn't properly processed and they killed their trees. So, size does matter.
  • by gruvmeister ( 1259380 ) * on Friday April 25, 2008 @05:34PM (#23203592)
    Being that kaolin clay binds with water and causes clotting, does this mean that this stuff will work on people who have clotting issues, such as those on blood thinning medications or hemophiliacs?
    • Both quikclot and celox will work for people with heparinized blood or other anti-clotting factors. The clot is formed by the agent and not the blood's own fibrins. I'm sure this new product works in much the same way.

      -b
    • Being that kaolin clay binds with water and causes clotting, does this mean that this stuff will work on people who have clotting issues, such as those on blood thinning medications or hemophiliacs?

      Short answer: No.

      Longer answer: People with clotting issues are lacking in some of the components tha tmake clots, such as the platelets, or the proteins that turn into the fibrous strands, or the components that control the clotting reaction. All the kaolin does is accelerate normal clotting - there are othe

  • Is it just me, or did that seem like an advertisement for a company and their product, moreso than there being anything of substance? It isn't like this is groundbreaking chemistry either.
  • I use Celox already (Score:4, Informative)

    by greyhueofdoubt ( 1159527 ) on Friday April 25, 2008 @07:40PM (#23204430) Homepage Journal
    The last time I was deployed in Iraq, we were all issued Quikclot packs in our trauma bags; I'm sure that if I needed to use it, it would have worked fine. However, Quikclot causes pretty severe burns and pain when it's used; in addition, the hard 'clot' that is formed is a PITA for surgeons to remove.

    In my personal trauma kit here at home, I use Celox:

    http://www.celoxmedical.com/ [celoxmedical.com]

    It is chitosan-based but claims to not affect people with seafood-based allergies. It produces no heat and is removed easily by water irrigation. I am curious why the DoD has not moved towards this product; you can get the celox-infused gauze that works much the same as this kaolin-based product already. If any of you are EMTs or just interested in having a good hemostatic agent in your kit, you should look into Celox. When everything else is equal, the disadvantages of Quikclot make Celox the clear winner.

    -b

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