Grow Your Own Heart Valves 180
A user writes "Medical researchers in Britain have succeeded in growing a heart valve from adult stem cells taken from bone marrow. The research is being reported in the journal of the Royal Society today. Growing a heart value from your own cells means that tissue rejection isn't an issue."
Whole heart next? (Score:5, Interesting)
At some point, transplants from donors will be for emergencies only, and the shortages and wait lists will be a thing of the past.
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Re:Whole heart next? (Score:5, Informative)
Until the last two or three years (if I remember correctly, the time frame may be off), with adult stem cells, they can grow a limited set of tissues only. Even now it takes work to make adult stem cells able to differentiate into any other cells. Embryonic stemm cells however can change into anything, without any modification. They are much easier to work with, and as of a couple of years ago they were the only option.
I can't remember if they can now make adult stem cells omni-potential, or just increase their potential to add just a few more cell types.
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If not for being being denied the ability to work with undeveloped stem cells would as much work have been done with Adult Stem cells? and would we still be seeing these kinds of results today?
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However, left to his own devices in his native environment, a human embryo will develop into an autonomous human. You are taking a life and converting it into property without giving that life a chance to decide.How does harvesting an embryo not equate to slavery? We Americans fought a war over this 150 years ago, and I find i
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It's flamebait because it's written in an angry tone and is "baiting" people to start a flame war. The same post could have been rewritten with a different tone and not been flamebait. A tone like that won't win many people over.
I'm not sure I can see calling it slavery. Cannibalism would be more appropriate, and just as flamebaiting. Even then, I think it would matter the source of the stem cells. Embryonic stem cells have been created without using an embryo. I those cases, a human life was neve
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It wasn't meant in an angry tone. This is exactly a question, raised 1.5 years ago in my law school Health Law class, somebody else posed to a PhD Bio-ethicist. He avoided answering the question, and I thought somebody here could pose an answer. Whenever somebody's right of autonomy is stripped and the person reduced to property status, we call it slavery. (Voluntary renunciation of autonomy would be indentur
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No. An embryo is an embryo, not a person.
A seed is a seed, not a tree.
Or a better analogy is: Flour and eggs are flour and eggs, not a cake.
An embryo would NOT become a human on its own, and this is why we do not treat it as a human. On its own, an embryo stops growing and developing, almost immediately.
An embryo cannot communicate at all, thus it cannot consent. Trees communicate and react more than embryos do, and there is no moral problem keeping and controlling tree
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What point are you trying to make? Would you like the reader to jump to the conclusion that because of this similarity we would then treat embryos as we treat infants? Someone has marked this comment as "insightful" - but I don't see why.
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Obviously.
Would you like the reader to jump to the conclusion that because of relationship of seed to tree that we should treat embryos as seeds? Shouldn't we therefore treat infants as saplings? How about a novel approach: Let's treat embryos as embryos?
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First of all you can argue that an embryo is a person but it would not be a strong argument. An embryo does not have a free will. Nor is it self-aware or does it have a conscience, as it does not yet have a functioning brain.
Secondly, I understand that you are argueing from a juridical point of view, but
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You must be new here.
#ifndef _SARCASM_H
#include <sarcasm.h>
Anyone who disagrees with the Slashbot hive-mind is obviously a reichwing Christianist deathbeast who must be silenced by the oh-so-tolerant-of-diverse-opinions progressives.
#endif
What I found disappointing was that the original poster in this thread was surprised that it was adult stem cells
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So taking an embryo and using it for science is wrong, it's murder, etc, etc. Yes, I agree to some extent. What about all the potential humans flushed down the toilet by those dreadful female teens during their period? Shouldn't they be forced to mate at every opportunity to enable the ovum of the month the chance to become a human being? After all, women typically ov [wikipedia.org]
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This is true for any organism that reproduces sexually, by the way.
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By your example, yes. It is often these embryo's which are almost always destroyed, that could be used for stem cell research...It's not all about abortion. Not even cl
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There is nothing inevitable about discarding embryos.
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That being said, I'd have no problem donating an embryo. The problem is, the number of embryo's created every year far outstrips the demand. My example of 9 extra embryos is reasonable. Some people have even more created, especially if they're trying to select around a hereditary condition or something.
So, for every couple who goes i
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Your supply/demand curve is off by a few factors. You rarely implant one embryo. It's an expensive procedure and often they don't take. This is why you have so many stories of multiple births due to IVF. So out of those 10 embryos, the original donor would probably use 2-4 and if they had excess implantation, selectively reduce (which is one of the major reasons why the Church is against IVF, it promotes abortion). Y
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The truth of it is, that sperm + egg - womb = nothing. It's a pile of potentially useful genetic material. Stick it in a womb for a few months, then you have a potential human being. If it survives to leave the womb, then you have an actual human being.
This is the only practical way of
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Why, because you said so? What criteria are you using for what makes a human being a human being? For that matter, given that there is no widespread consensus on the issue of what "life" is, exactly, in any of the major fields of interest - biology, religion, psychology, philosophy - which is why it's an issue to begin with, upon what authority do you draw from to make
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If you don't believe that full personhood begins at conception, then when do you believe it begins? If your answer is "I don't know", then shouldn't you err on the side of caution and support the protection o
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"If you don't believe that full personhood begins at conception, then when do you believe it begins?" It happens gradually. There is no magic point that you are instantly human. That is why we DO err on the side of caution, and don't allow abortions a week before a due date. While we might not know exactly when the line is crossed between organ and human, we do know that it is not
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No, there could be a miscarrage.
You are taking a life and converting it into property without giving that life a chance to decide.
We do the same thing to other living things all the time. We kill catapillers before they become butterflys.
How does harvesting an embryo not equate to slavery?
Because its a mass of cells, and not a human being? There's no brain, arms, legs, heart, anything. It cann
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A human embryo has no native environment ("native environment" being the environment in which you are born), and left to its own devices, a human embryo will, fairly certainly, die.
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From what I understand, being able to bring an adult stem cell to be omni-potential means that it could be made to evolve into an embryo and then a living human being (a clone). So who is to say that this life should not be protected ? Does religion even have a point of view on the issue ? If every unicellular life is sacred as long as a complete human DNA is present, and that it can evolve into a full life, should we preserve amputated members as soon as adult stem cell research is s
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The only reference in the Bible I know of to abortion is the punishment for causing miscarriage by hitting a woman, but not otherwise hurting her (which has a separate, much
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Idea worth thinking about (Score:1)
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Yup:
http://en.wikipedia.org/wiki/Umbilical_cord [wikipedia.org] (warning: some not-so-pretty pictures)
Check out the section on cord blood.
Adult vs. Embryonic stem cells... ? (Score:1)
From what I can see, however, the folks doing research with the adult-stem-cells are outpacing embryonic research by leaps and bounds.
This sounds like a bona-fide adult-stem-cell success.
From what a vaguely remember, the embryonic-stem-cell experiments have either failed outright, or ultimately failed after initial success. We've heard lots of promises, but adult-stem-cells are delivering, wher
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You put $10B into research on ethanol from corn, vs $100K into research for ethanol from cane... Which one will show up better? Which one is actually better?
The scales were weighted and the measurement isn't good.
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Another argument would be that embryonic stem cell research is 'higher level' research - more theoretical than practical. The lessons learned there could filter down and help adult stem cell research develop practical treatments.
For one thing, without some extensive modification you'll have problems with immune systems rejecting the cells; just like with transplanted organs unless you make it a ha
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So it wouldn't be to grow you a new heart valve, but to understand how the heart valves grow.
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Now? Maybe. It would require a lot more effort though (there are methylation sites on the DNA that "turn off" genes, and these methyl groups need to be taken off, but only some, not all if I remember correctly. There may be other factors as well. And this has to be done without killing the cell.
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Then there's the whole 'tarred brush' problem - current administrations don't make a huge differentiation between fetal stem cells and birth stem cells. There are also some ethical problems with using the discarded parts of a baby (cord&placenta) in research when the donor is a minor and unable to give consent. You'd think
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Embryonic stem cells however can change into anything, without any modification. They are much easier to work with, ...
Just to put in some requisite corrections to some popular (mis) understandings...
The clause, 'without any modification' is flat out wrong, applied to either type of stem cell.
I'm not a stem cell researcher myself, but It's my understanding that adult stem (AS) cells are actually easier to work with. In addition they're clearly more readily available. That being said, this is all the bleeding edge of medical and life science and *nothing* is 'easy'
... and as of a couple of years ago they were the only option.
I'm assuming what you mean by this statement is that 'they
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Well, if a "and never have been" is in there, that makes one of us.
Just to put in some requisite corrections to some popular (mis) understandings...
The clause, 'without any modification' is flat out wrong, applied to either type of stem cell.
I'm not a stem cell researcher myself, but It's my understanding that adult stem (AS) cells are actua
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Embryonic stems cells gain of press after articles started coming out about non-embryonic stem cells. Since embryonic stem cells have the potential of doing alot more, ignoring all the additional problems they cause, when the stem cell craze started alot of venture capitalist started investing in them. After pumping a bunch of money in embryonic stem cells it came up tha
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Yeah! (Score:4, Interesting)
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As the father of somone with a slightly defective valve. We have been told that at some point in the future this valve will need to be replaced. How wonderful it is that the replacement will no longer need be reduced to the choices of cadaver, pig, or mechanical.
Yeah! Too! (Score:2)
OEM parts (Score:4, Funny)
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However, I would mention, don't make plans to go through this several times. Your doctor will generally tell you to minimize the times you have an operation. Listen to him well. It sucks. And it sucks more each subsequent time. And to top it off, there's the wonderful non-zero risk every time.
I look forward to the day when we don't have to use cheap replacements,
Preventing Rejection (Score:5, Funny)
What slashdotters need is a way to grow a girlfriend from their own cells.
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Masturbation perhaps?
This exact set of jokes about clones showed up in a SciFi short story in the mid-60s (I believe). I can't recall the author or title for the life of me, but the story concerned a large number of clones (magically turned into both sexes) who worked as a team, mining something out of some remote planet. The two non-clone supervisors found it very difficult to understand the social interactions, etc etc.
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The Clone Song
By: Isaac Asimov
Tune: Home On The Range
Oh, give me a clone \ Of my own flesh and bone
With its Y chromosome changed to X.
And after it's grown, \ Then my own little clone
Will be of the opposite sex.
Clone, clone of my own,
With its Y chromosome changed to X.
And when I'm alone \ With my own little clone
We will both think of nothing but sex.
Oh, give me a clone, \ Is my sorrowful moan,
A clone that is wholly my own.
And if she's X-X, \ And the feminine sex,
Oh, what fun we will have when we're prone.
Clone, clone of my own,
With its Y chromosome changed to X.
And when I'm alone \ With my own little clone
We will both think of nothing but sex.
My heart's not of stone, \ As I've frequently shone
When alone with my own little X.
And after we've dined, \ I am sure we will find
Better incest then Oedipus Rex.
Clone, clone of my own,
With its Y chromosome changed to X.
And when I'm alone \ With my own little clone
We will both think of nothing but sex.
Why should such sex vex, \ Or disturb or perplex,
Or induce a disparaging tone?
After all, don't you see, \ Since we're both of us me,
When we're having sex, I'm alone.
Clone, clone of my own,
With its Y chromosome changed to X.
And when I'm alone \ With my own little clone
We will both think of nothing but sex.
And after I'm done \ She will still have her fun,
For I'll clone myself twice ere I die.
And this time without fail, \ They'll be both of them male,
And they'll each ravage her by and by.
Clone, clone of my own,
With its Y chromosome changed to X.
And when I'm alone \ With my own little clone
We will both think of nothing but sex.
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That's a good idea... I think there are numerous slashdotters that are sufficiently in love with themselves to prefer a their clone... Wait... what about the gender! Oh No! What have WE DONE?!?
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Make sure you screen for some defeciences first though.
Tissue Rejection Not an Issue (Score:5, Insightful)
The problem with heart valves is that if you replace one with, say, a pig valve, it won't grow. For adults, this is not a problem, but for kids, it means they'll have to have a replacement in a few years as their heart literally grows out of the valve(s).
This new grow-your-own approach would probably be best for children. For adults, however, heart valve replacement is actually fairly routine and requires no anti-rejection drugs afterwards.
Re:Tissue Rejection Not an Issue (Score:5, Informative)
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When I was getting ready to have my aortic valve replaced, the surgeon showed me a porcine valve; in appearance it is nothing like leather, but rather an incredibly thin and flexible structure. The aortic valve is not like a flap valve, but more like three little plastic grocery bags hung from the sides of a pipe. When blood flows one way, the leaflets collapse against the wall; when it flows the other way, whap, they fill up and block the tube.
There is no rejection problem with porcine or bovine heart v
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Old Colony vs. New Colony (Score:1, Troll)
Of course the British are working on doing this in labs. They lost all their colonies. But we don't need this stuff; this kind of thing is what Puerto Rico is for
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Silly question, but... (Score:4, Interesting)
IANanMD, but I would think this would pose problems with usability, wouldn't it?
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A stem cell replacement would develop normally (theoretically). The chances that I'd actually let them put such a "replacement" in me is very very low as it would not have been properly "worn" for my age and lifestyle (history of running marathons and intense workouts). The mechanicals are very efficient and I wouldn't trust a vat valve for my aorta today. I'm just not the guinea-pig type.
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Sometimes its genetic. Sometimes a cosmic ray hit one of the stem cells crawling down to develop the original. Sometimes the mother's alcohol intake interfered with the proper acquisition of nutrients and scaffolding to build it properly.
The Religious Right Extremists... (Score:1, Interesting)
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You'll notice that a lot of them are strongly against abortion, but all for fertility treatment, even though it's rather more like playing God...
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I cannot believe that this post got rated 4 Interesting! It is a troll and a screed. If you need any more evidence of this, just look at the last parag
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Me, I just wish we'd play god a bit more often. We seem to be a bit more enthusiastic about playing the other bloke.
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That's nothing! (Score:4, Funny)
New Valve? (Score:2, Funny)
I'm open to it.
Too soon?
Being reported in theJournal of the Royal Society? (Score:5, Funny)
The Daily Mail is famous for blowing medical reports out of all proportion - they "cure cancer" an average of 2 or 3 times a year.
Re:Being reported in theJournal of the Royal Socie (Score:2)
I'm waiting for the Mail to announce a cure for death
Caucauios optimisim (Score:2, Insightful)
Also I couldn't find a link to the paper by Dr. Yacoub which should have been here [royalsoc.ac.uk]
Yay heart valves (Score:2, Interesting)
How many years does it take? (Score:2)
Been there, done that (Score:3, Funny)
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For this to be scientific, you have to be able to reproduce the results and grow it again
Painless Heartbreak Recovery (Score:2)
Why can't we use some of the 400,000 blastocysts discarded by fertility clinics every year?
Then we'd just need the expensive second surgery to implant them, or the tissue externally grown from them in a lab. Eventually maybe we'll get a stemcell pill, or better yet, some kind of herbal tea that stimulates our own stemcells. But first let's get rid of the
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s/fetal/embryonic/
Re:php (Score:5, Insightful)
Thanks.
PS: The point of research is to find out how to do things. It was unlikely we would ever use embrionic stem cells as "standard" treatment but we could have learned a lot about how cells work much sooner.
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You are double plus good at double speak. (1984 is a book read it and thinks about what you're saying.)
PS: If you assume killing babies is bad and embryonic research kills babies then you might assume it's an ethical decision. But if one of your facts is wrong then it's a pointless argument.
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I am not actually addressing the moral argument in this post, just the pure utilitarian one that so far as we know, embry
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There are zero restrictions on private money going into embryonic stem cell treatments. States do fund and private groups can fund what the federal government does not want to fund. But the private money gen
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The NHS, free at the point of delivery, unless it's something to do with your teeth, but Clove Oil is supposed to be good for toothache.