Researchers Find Potential Cure for Cancer 324
MECC writes "Researchers at Johns Hopkins University may have found a way to kill cancer cells without radiation or toxic chemicals. The group is taking the step of patenting the idea, as this new approach using sugars may hold real potential for the fight against cancer. This is not the first approach to use sugars, the article states, but is (by the researchers' estimation) the most successful. From the article: 'Sampathkumar and his colleagues built upon 20-year-old findings that a short-chain fatty acid called butyrate can slow the spread of cancer cells. In the 1980s, researchers discovered that butyrate, which is formed naturally at high levels in the digestive system by symbiotic bacteria that feed on fibre, can restore healthy cell functioning ... The researchers focused on a sugar called N-acetyl-D-mannosamine, or ManNAc, for short, and created a hybrid molecule by linking ManNAc with butyrate. The hybrid easily penetrates a cell's surface, then is split apart by enzymes inside the cell. Once inside the cell, ManNAc is processed into another sugar known as sialic acid that plays key roles in cancer biology, while butyrate orchestrates the expression of genes responsible for halting the uncontrolled growth of cancer cells.'"
All this... (Score:5, Funny)
Re:All this... (Score:4, Funny)
At least... (Score:4, Funny)
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Bravo, well played sir. But does that mean we're nearing the end game, or do we just keep researching numbered future techs now?
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Totally. The shortage of Luxuries has been a killer lately. I mean, sure, I got a Wii, but all those guys in red yelling outside? Poor guys missed out. And the Elvis impersonator doesn't seem to be impressing them much...
Drama, anyone? (Score:3, Insightful)
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Old news (Score:2, Funny)
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Mmmmm (Score:3, Funny)
Mmmmm, sugar donuts. Is there anything they can't do?
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so, is it like an even/odd thing? one too many donuts and you're screwed, one more and you're okay? is it by donut unit, or pounds, or dozens? bakers or regular? we simply must know!
She's a ManNAc, ManNAc, (Score:5, Funny)
Patent ? Idea ? (Score:5, Insightful)
"The group is taking the step of patenting the idea"
Patenting
What the hell
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People who think the patent is the bigger story here need some perspective, IMHO.
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Defensive? (Score:4, Informative)
For the guy asking about perspective, take a look at the sugars vs. hepatitis article from a couple days ago, where they were working around a patent for treatment to produce a low cost version, while the drug company charged $14,000/yr for treatment. A cure for cancer is worthless to most of the population if it costs a million bucks.
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The drugs cost very little to produce, you're paying for all the research and profits.
I hate to say this... (Score:2, Insightful)
Because the money isn't in the cure. The money is in the treatment.
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It couldn't have anything to do with cancer being difficult to successfully treat, could it? Or that most of the really nasty cancers (lung, pancreatic, bowel) are detected pretty late in the game, huh?
Naw, must be greed.
Re:I hate to say this... (Score:5, Informative)
I've worked in the healthcare industry for years. Trust me when I tell you that they are about money first, second, and third.
You are so GD right! (Score:2, Interesting)
Non-Profit is just a tax status. Meaning, you're more than welcome to make as much money as you want, but you are limited to what you can do with those profits. Some non-profit CEOs do in fact make eight figures a year.
The other thing, to support your argument further, I once knew a nutritionist who worked with folks to reduce their heart disease risk by helping them with their diet. The CEO of t
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Re:I hate to say this... (Score:4, Informative)
Just a clarification: just because an organization is registered as not-for-profit does not mean it is not in the business of making money. Not-for-profits need just as much income to operate as regular businesses. The primary difference is the after-expenses dollar doesn't go into pockets, it returns to the organization (or funder) to spend it during that fiscal year. However, salaries can still be high and spending can be furious, just like other businesses.
I'm not saying you are wrong about health companies being driven by money, but many people commonly mistake not-for-profits with Mother Theresa, and that is usually false.
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I made that point, numbnuts.
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No, but this guy does [slashdot.org], and he agrees with the parent that you're full of it. You sound like that loon who told me that the American Heart Association didn't want the public to find out about the [spooky]dangers of aspartame[/spooky] because they were making too much money off of heart disease.
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Re:I hate to say this... (Score:5, Insightful)
Everyone who is whining FUD about there being a money grubbing axis of evil, clearly doesn't work in the real world. Having been completely federal grant funded for 2 years at a university, I can tell you, the lights don't stay on by themselves, the phone bills don't get paid, failed trials still cost the same as succesful ones... Even "non-profit" organizations can't lose money continously (and grants are being slashed every day), especially when conducting trials which can take years to conduct and hundreds of millions to complete. I'm not saying big-pharma is the least bit altruistic (and yes, they would sell their grandmother in a heartbeat) but since we don't live in the era of star-trek-the-next-generation where poverty has apparently been eliminated, and work and funding is apparently universal, one must make money to stay in business.
There is not a conspiracy for chemotherapeutic drugs to hold-down cures (as those would be the "new" drugs for sale by big pharma if they became useful therapies), but a conspiracy by cancer cells to continue living despite our best efforts. I have heard the same FUD about big-pharma sitting on miracle antibiotics, but in truth those would be huge sellers, it's just that bacteria have gotten very good at living over the last several billion years.
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I was looking for a comment like this so I wouldn't have to write it myself. Just to add to the notes of caution + hope, the research on cell surface receptiors, signalling molecules, and the like, sounds very promising. A couple of months ago, there was a report on the BBC [bbc.co.uk] about a different "sugar" molecule that is involved in cell signalling during blood vessel growth. Since tumors can't grow without lots of new blood vessels to supply them, this approach can stop them in their tracks. The trick is ge
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Certain types of cancer have been very difficult to treat, either due to late detection, or the sensitivity of the surrounding area (e.g. brain tumors). Childhood leukemia, her specialty, has gone from a 50% survival rate in the late 70's to a 9
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I seriously doubt that the pharmaceutical companies would be able to block this if it's proven to work - if their trials prove successful then they'll make that info public immediately, and once the public
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I know how snarky I sound, but Jesus
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Sheesh. You know, even mean, nasty, conspiratorial CEOs with giant handlebar mustaches get cancer, too.
Re:I hate to say this... (Score:4, Interesting)
The "health care industry" can be relied upon to act in self interest of each of it's parts, not the whole.
If Ford came up with a car that everybody wanted to buy (this is a thought experiment, so doesn't have to be anything short of pure fantasy) and it lasted four times as long so they could only sell a quarter of them. What do you think would happen? They call up Toyota and say "you know, we all make some money here we'll just shelve this".
No.
They go at it full blast and try to make as much money with what _they_ can do, to hell with every other segment of the industry.
So, the first research place to come up with a better cancer treatment and even if it is cheap overall, if they can patent it and make more money than they do now (keep in mind, they know other smart folks are working on the same problem, they gain NOTHING by keeping it secret) they'll do it.
You are stupidly assuming the paranoia about the big health care industry is correct. Big oil, big pharma, big lumber, whatever... they only act in concert because it's a mob rule where their self interest seems to make them do pretty much the same sorts of things. As soon as one can break out of that pattern and make more money, they'll do it. Or, perhaps some other company comes along with a "disruptive technology" and does it. Either way, the status quo is due to the issues involved, not due to collusion amongst the parts of the industry.
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However, I'm not so cynical to believe companies would prevent a cure for cancer from happening. They are simply guilty of not making big investements in this area, because of lack of profit.
There are a number of practical reasons why it would be foolish for a company to try to preve
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Big business screwing people or putting them in harms way driven by profit is not exactly unprecedented.
What needs to happen is the goverment needs to start funding areas that have little profit motive. Look at HDL, t
Re:I hate to say this... (Score:5, Insightful)
Only on teh InArw3b could this be modded "insightful".
Let's see, there's a really complicated, deadly family of diseases.
Why haven't we cured them? 2 possibilities:
1) it's really hard, and we haven't figured it out yet
2) a secret cabal of giant corporations is colluding to make sure nobody releases it so they can make more money.
Obviously, 2 is the logical answer, right?
I'm sure the recipe for the cure is on a 3x5 card stored right next to the Ark of the Covenant in that warehouse at the end of Indiana Jones. I believe Elvis is the warehouse guard, too.
Overblown story... (Score:5, Informative)
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One promising thing, it effects only the damaged cells whereas chemo and radiation have no such ability and just crush the immune system.
Patenting (Score:2, Interesting)
Nice to know they're spending their time filing for patents instead of, well, trying to use it to cure cancer.
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Why can't they do both? Seriously do you think the scientists have stopped working and are now spending every second they have filing the patents or are lawyers hired to do this?
Also what is wrong with people benefiting from their potentially groundbreaking work?
Oh, I forgot, on communist slashdot people should work 168 hours a week for free, live in a van down by the river and starve to death befo
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Man, we should all reject the whole concept of money -- especially if it's derived from the evil patent system -- and find a way to just live on love.
Malignant Property (Score:5, Insightful)
The logic contained in that "as" apparently dictates that curing cancer is more important for making money than for everyone's health. Apparently without any explanation needed, or question expected. Also unquestioned is the vast amount of money spent by the public (you and your family, for generations) subsidizing all the research these "inventors" used to produce their new idea.
There's a lot of discussion on Slashdot of justifications for piracy of media content. Fighting the arbitrary assignment of all value from medical inventions to the last people to use their predecessors to cross a commercial threshold seems not only more obviously moral, but more relevant to basic survival. And a stronger study in the arbitrary contrasts between the "robber" and the "robbed".
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Fibre (Score:2)
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It's great to live long enough to see validation: Pritikin diet for heart disease, whole unprocessed grains and veggies for cancer. I'm old enough to remember when brown rice and Pritikin were fringe cult practices.
Not that I'm against the futurist ideal that someday we'll consume purified total nutrition. But stories like this suggest that we haven't learned everything about nutrition yet, and, until we do, "natural" isn't such a meaningless _concept_ -- although, paradoxically, a rather meaningless foo
I was thinking that myself... (Score:2)
Its cool they posted my submission (Score:5, Informative)
Not a complaint - an observation.
Cure for cancer patented.... (Score:5, Funny)
Pity medical advances can't be GPL'd (Score:2)
Cancer stem cells (Score:4, Interesting)
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Don't hold your breath... (Score:3, Interesting)
Much ado about...not much (Score:5, Insightful)
Relevant information: not yet tested on whole living systems. They pissed off some cancer cells in a Petri dish. Big deal. You know what kills cancer cells in Petri dishes? A sledgehammer. Cyanide. Dynamite. Driving over the Petri dish with a Buick. None of these therapies are likely to be useful, however.
Wait, you cry. Laetrile released cyanide in vivo, and that was an (alleged) therapy.
Yeah, systemic poison-giving is already at hand. It is called chemotherapy, and it sucks. It can work, but it is never pretty.
Infusing the patient with sialic acid, which will enevitably infiltrate by this method into every cell, cancerous or not, is twiddling with every biological pathway with which sialic acid interacts. Butyric acid (the essence of sour butter)? Rub it on. Hasn't harmed anyone yet - whats the LD50 for old butter?
Maybe there is promise here, and maybe there is just breathless scientific prose in a self-serving PR release.
My guess is that once whole animals come into the picture, these researchers, as many many before, will find out that biochemistry farts in your Petri dish's general direction.
Calm down, people (Score:5, Funny)
A bit too early to get excited... (Score:4, Interesting)
Again? (Score:2, Insightful)
Go find some interview with a journalist who had been or still is fighting with this illness. They all say they've become more cautions when choosing such news for headlines in their newspapers or tv news.
To quote Champ Kind (Score:2)
WHAMMY!
It is partially offtopic... (Score:4, Interesting)
Most of our body is made of muscle or fat cells, yet sarcoma is quite rare.
Has someone studied a way to make the other kinds of cells so resistent to cancer ?
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That's why sarcomas and neuroblastomas (neuron
High fibre diet is the answer? (Score:4, Insightful)
If the claims are true, the vegetarians and those ethnic groups that have lots of fiber in their diet should have lower cancer rates. Some epidemiological (sp?) study should be able to figure out the patterns. Should study groups with highly off the norm dietary habits. Results would be intersting.
insert your favourite big agro conspiracy theory that has depressed the natural and less refined food consumption in America
Big impact... (Score:2)
no such thing as "cancer" (Score:3, Insightful)
I thought there was already a cure? (Score:4, Funny)
Good news for Lincoln, leader of The Americans (Score:2, Redundant)
Here we go again. (Score:4, Insightful)
The idea in the article sounds interesting, but it is clearly being framed in a way to provoke an audience to become outraged at the idea of "patenting the cure for cancer."
Shirley there are researchers here on slashdot who have worked in cancer, who are rolling their eyes about now, in fact, I have an extended family member who is a PI on a long standing cancer research project and I can't wait to hear their take. I suspect this is old news among people in the cancer research community, but I'll have to wait for the school year to start before I can ask. I won't even forward an article with the title "Cancer Cure Patented", come on!
Cute (Score:3, Interesting)
So they have found an high tech method to attack cancer based on the same principle you'd get by eating enough vegetables...
Riiiight....Mary Poppins was right! (Score:5, Funny)
So, Mary Poppins was right! A spoonful of sugar does help the medicine go down! And in a most delightful way, too!
What if they did cure cancer? (Score:3, Insightful)
How would that effect our attitude towards things that cause cancer or are seen as highly carcinogenic? Would smoking become the equivilent of poor oral hygiene (probably not considering the other problems)?
It's often interesting to wonder how or if our priorities or attitudes would change if suddenly what was a major problem for decades becomes considered an easily curable condition.
Don't be so cynical (Score:5, Insightful)
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I'm confused by 2)..
if the ones who find it and publish the procedure and finding DON'T patent it, and *later* comes Big Business(tm) and tries to patent it.. wouldn't the patent be invalid because of prior art or something?
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In theory, they could use this basic patent to prevent pharma from harvesting cash in the future. But they won't. This is academia, where the system cannot function without large cash flows. Do you really think that university presidents with solid six-figure salaries, thousand square foot office
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I can't say I know much about state schools, but at the very least I have my doubts that things are so bad
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3. So that Magacorp has the incentive to license the invention from the University so that it has a chance of actually reaching patients.
Drug Development is an expensive business. Unless there is a financial incentive (which at best is the possibility of future profits, there are no guarantees), it is very unlikely that the required funding will be made available to conduct the expensive clinical trials required for FDA approval.
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Megacorp can't steal the idea and patent it for themselves
Yes, it is possible that applying for the patent was a prophylactic measure against corruption of further research by legal drug lords. The patent tool can be used for good as well as for evil.
The test of these researchers morals and ethics is yet to come. They will be judged on how expensive and restrictive they are in licensing the use their patents. John Hopkins has an active OpenCourseWare program, so the sponsoring institution is not oppose
Re:Don't be so cynical (Score:4, Insightful)
The point of patents is not to make companies money, as you seem to imagine, it is to make sure that companies share their secrets. The alternative to patents is not wild free information, it is corporations taking secrecy to whole new levels, and never sharing ANY of their findings, to keep their competitive edge.
Re:Don't be so cynical (Score:4, Insightful)
My thoughts on any "cures" from this country (Score:4, Funny)
Re:FP? (Score:4, Insightful)
Re:FP? (Score:4, Insightful)
My mother died last year from cancer. The type of cancer she had is not very frequent so there's not much money to make. The chemo-therapie and other therapy forms were not specifically developed for this type and do not work very effective and so she died.
I also travel frequently to developing countries and people I have known there died from malaria, no vaccination or anything because the people mostly affected are poor. And so there is not much research.
No, sir, no "anti-corporation blabber". It's just a plain fact that corporations (and by that patents) will help you only if there is enough money to be made. That is no blabber but pure clean capitalistic economy.
It is nothing else. It doesn't matter how many people are affected (malaria and AIDS) or how severe the problem is (cancer vs obesity), it's just about profit. So do not start with family member or the children examples. Business means revenue over humans.
Re:FP? (Score:4, Insightful)
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I'm not saying I have an answer. But since - as far as I am concerned - medicine is about the well-being of people and business is about profit, they are not a match made in heaven.
But we have that combination and now we have to see how we get along with that, "family member" and "the children" examples don't help much.
I could make up a one like: "Imagine you are poor and one of your family members has XY and medical care would be a human right and free." It doesn't help with concrete problems either.
Re:FP? (Score:4, Insightful)
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Re:FP? (Score:4, Insightful)
Your comparison is obviously invalid.
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Has it? Really? Got a cite for that? Because that number looks a bit, um, wrong.
That's 3550 potential cancer cures at your example rate, in the span of 4 years.
OK so what do you feel happens, exactly, to the money that is spent on the war? Where does it go? What does it buy? Who does it employ? What do _they_ then buy with it? The money doesn't just evaporate, it gets spent on high-tech items. Which employ high-tech people. Which improves the jo
Re:FP? (Score:5, Insightful)
I am MUCH more trusting of these university research guys than some corporate pharm lab research guys as far as doing the right thing with the patent. Hopefully it won't be misplaced, but lets not jump to conclusions.
Re:FP? (Score:4, Insightful)
Grow up. The company that comes up with a truly effective, broadly acting cure for cancer is going to make more money than God, even if they provide it at a low cost. And because every company hopes to be first, everybody has an incentive to throw a hat in the ring. And of course, once you make that huge investment, even if you can't be first, you still go to market, meaning that there's at least some competition to bring prices down.
Pharmaeceutical companies do plenty of seriously messed up stuff in order to make money, but disease profiteering isn't one of them. If there was the slightest shred of proof to show that they're purposefully avoiding developing a cure so they can instead sell palliatives, don't you think patients advocate groups would be screaming for blood from the rooftops?
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Besides which, as other posters have already pointed out, this is an academic group, not "Big Business"; they're not out to scalp people.
(Oh, and "FP?"? Sad, sad, sad.)
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Thermonuclear Holocaust