Near-Complete Cure For Diabetes In Two Years? 271
resistant writes "Researchers at a Toronto hospital have stumbled upon a dramatic treatment for mouse diabetes, with large implications for the treatment of diabetes in humans. From the article: 'The islet inflammation cleared up and the diabetes was gone. Some have remained in that state for as long as four months, with just one injection... They also discovered that their treatments curbed the insulin resistance that is the hallmark of Type 2 diabetes, and that insulin resistance is a major factor in Type 1 diabetes, suggesting the two illnesses are quite similar.'"
Update: 12/17 03:46 GMT by KD : resistant adds that the Cell Journal article is posted as a PDF as well as in plain text.
Update: 12/17 03:46 GMT by KD : resistant adds that the Cell Journal article is posted as a PDF as well as in plain text.
A treatment for diabetes? (Score:5, Funny)
Re:A treatment for diabetes? (Score:5, Funny)
Bad Humor is expected (Score:5, Funny)
We all know that slashdot is full of bad humor, and if we want good humor, we have to look somewhere else. [icecreamusa.com]
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I say we punish those pun punting pundents!
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Pinky are you there?
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Dude!
Re:A treatment for diabetes? (Score:5, Funny)
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Good News! (Score:3, Funny)
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IAT1D (Score:2, Interesting)
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Hm (Score:5, Insightful)
Slashdot Title: Near-Complete Cure For Diabetes in Two Years?
Unfortunately (Score:3, Funny)
"Are you a man or mouse?"
for the injection to be successful, otherwise you just develop a serious cheese addiction.
Yet again, it's always the mice (Score:4, Interesting)
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FTFA: The researchers caution they have yet to confirm their findings in people, but say they expect results from human studies within a year or so.
If the Canadian version of the FDA lets them fast track the approval process, this really could be the kind of medicine that is "five years" away instead of "five, but we really mean 10 years".
Anyways, this treatment is only a 'temporary' (up to 4 months for some mice) cure. That's better than nothing though
Re:Yet again, it's always the mice (Score:5, Informative)
http://www.cell.com/content/article/abstract?uid=
the link to the PDF for the entire article is to the right of the page
The full article text (Score:2)
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Re:Yet again, it's always the mice (Score:5, Insightful)
Yes, because using Google is so damn hard. Enter "Cell Journal" into Google. First link. The Article [cell.com] is available.
Re:Yet again, it's always the mice (Score:5, Insightful)
Specific animals are usually chosen for studies because certain biological systems function in a very similar way to the relevant human biological system. Heck, plenty of drugs that work on humans work on cats and dogs and probably lots of mammals. Certain NSAIDs, antibiotics, steroidal anti-inflammatory drugs, benzodiazepenes (anti-anxiety drugs like valium), and some chemotherapy agents developed for use in humans, just to name a few drugs commonly used with cats and dogs off the top of my head.
Your suggestion then that the results of animal trials bear "no relation" to how they will perform in humans is simply nonsensical. Many drugs may seem to be active in animals, but in humans turn out to be no better than other drugs on the market in terms of efficacy and worse in terms of side effects, which commonly leads to dropping them from commercialization. Differential comparisons of drug efficacy in animal models aren't necessarily useful to determining which drugs will be the most effective in humans, and side effects are not always equivalent, but that's not the point of animal trials - the point is to establish that the basic biological mechanism works in vivo and to get a vague concept of possible safe dosing in an animal model before moving to initial human safety tests.
I fail to see how you and the other animal rights loonies can have such a poor grasp of how scientific research works and yet feel qualified to comment so authoritatively on it.
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for example, omeprazole, a drug in the class of "proton pump inhibitors", which stops acid from being produced in stomach, causes gastrinoma (a type of hormone-secreting tumor) in experimental animals but not in human...
these things are sometimes important
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This couldn't come soon enough (Score:4, Funny)
Mouse Masters (Score:3, Funny)
Inflamation (Score:5, Interesting)
Inflammation and evolution (Score:5, Interesting)
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What type of disease were they postulating? Bacterium? Virus?
Does long ago mean 5,000 years, as in Egypt or Babylon, 50,000, as in Neandertal interaction period, or 500,000, as in pre Homo-Sapiens?
Bring on the weight loss (Score:5, Interesting)
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What you're thinking of is type 2 diabetes, which is probably *caused* by excess weight leading to i
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He's very skinny, btw.
Few Years away (Score:2)
Interesting treatment of diabetes but it is still years away for human use. Until then we have to live with complete 100% cure to diabetes -- pancreas transplant. Does anyone plan on donating their healthy pancreas when they die?
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Pancreas transplant [discovery.com] is only used for patients who have a failed pancreas so it would really be their last hope.
The interesting thing is the simplicity (Score:5, Interesting)
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After all many people say pain is in the mind. So how much of it really is in the mind now?
Diabetics, please do not count on this (Score:2, Insightful)
And what happens?
Very little. The approach rarely pans out or is sustainable, like the islet transplant techniques of a few years ago.
Diabetics, go for a run. Eat sensibly, and care for your body. Anything long term, is years, perhaps decades away.
--Alan
Re:Diabetics, please do not count on this (Score:4, Interesting)
My son is a Type I diabetic and last month he had to do a year based timeline in math to learn about positive/negative integers. He did his on the discoveries related to diabetes and in particular insulin.
Lots of progress has been made over the years, and in particular the last 3 decades. The type of insulin he uses is just slightly older than he is.
The media is great at making everything seem like it is the next big discovery(witness the title of this article), but this is a pretty significant change in the understanding of the causes and possible cures of diabetes.
The injected substance is a natural substance already approved for injection for other medical purposes, and for this particular purpose (affecting nerve cells), although prior to this research no one had associated nerve cells with the onset of diabetes.
This research is as signifcant as it gets. Up there with the discovery of anti-biotics, and it represents a wave of change in how several diseases will be treated in the coming decade.
Re:Diabetics, please do not count on this (Score:5, Interesting)
I am (or was) a type 2 diabetic myself, so I know about getting my hopes up. A lot of strange things are happening in diabetes research lately, though, and it's starting to look like nobody really understood how it worked. Maybe they still don't, but they're at least starting to get a clue.
As for myself, I finally gave up on dieting last summer and opted for weight loss surgery. For some reason that nobody really understands yet, some forms of weight loss surgery cure type 2 diabetes about 75% of the time. Those were good enough odds for me, and I got lucky: it worked. I've been off of all the diabetes medications since the day I got out of the hospital. My blood sugar, while not quite down in the normal range yet, is lower than it was before then surgery when I was taking the medications. And losing 75 pounds probably didn't hurt either. :-) This isn't for everyone, but at least there are starting to be options.
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Your diabetes appeared to "dissappear" because you lost a lot of weight.
That's what I was expecting too, but it's not what happened. It went away immediately, right after the surgery, not months later after I'd lost all that weight. I don't know exactly why it happened; my food intake was definitely much lower than it had been before, but I was still eating. The same thing has happened to other patients I know personally, and anecdotally I've heard of one person who had the surgery to "cure" his type
But people will sitll complain (Score:2)
- Animal-rights wackos will complain about the animal testing involved.
- Fat-haters will complain this lets fat people get away with being fat without worrying about dieing from diabetes.
- And most of all, what about the hated drug companies who make a profit from this? How dare they expect to make a little money when all their drug does is cure diabetes? Greedy corporate bastards.
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I predict they'll complain regardless.
!!! meow (Score:2)
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A cure for diabetes is great, but ... (Score:3)
I'm just sayin...
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it probably would have been easier to just quit tariffing sugar and subsidizing corn so that they stop using the bane we know as "high fructose corn syrup".
Oh, corn syrup causes Type I Diabetes? I thought it was from the
government shipping "radioactive milk into black and poor communities" [omahaimc.org].
After all, if you are going to spout off bullshit conspiracy theories to ward off scientific research, at least pick a good one.
(BTW: I'm with you on the sugar subsidy thing. I can believe how much corn products are in
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-It's well known that sugar has high tariffs in America.
-It's well known that corn is highly subsidized in America.
-It's well known that HFCS is used as a sweetener in many products, and that this is due to its low price compared to sugar.
The controversial part was that it leads to diabetes. But that is at worst, a "crank medical theory" not a conspiracy theory. That's a completely different category.
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The fact that HFCS is used so widely, or even at all should be embarrasing to the American people. It's widely agreed upon that it tastes worse than raw sugar, is significantly unhealthier, and is more expensive to grow (without government subsidies). However, thanks to subsidized-capitalism, food manufacturers have little choice but to use HFCS in order to stay afloat.
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Knowing my luck (Score:2, Funny)
Reading the actual article (Score:4, Interesting)
The newspaper article is a not quite accurate either, although it has less hyperbole than the parent. What the study actually says is that it appears that the sensory nervous system is playing a role in the development and progression of diabetes. That is the "blockbuster", since it was thought to be an autoimmune disease.
If verified, it provides yet another avenue of investigation into diabetes control and possibly cure, but this is a first study. A lot of work needs to be done to go between this and a standard treatment.
Important? Yes. Break out the champagne and declare diabetes is cured? No.
A Paradigm Shift Like Ulcers? (Score:4, Insightful)
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The diabetes-accessory industry is going to hate this.
This will destroy a $20 billion a year industry.
Mice, pffft (Score:2, Informative)
Of course, human metabolism has turned out to be far more complicated than mice. The only value of mice tests is to
1. make sure it probably won't kill humans.
2. demonstrate an effect, and claim th
Re:Mouse diabetes? (Score:4, Informative)
Re:Mouse diabetes? (Score:5, Funny)
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Umm, I'm not sure if that was a joke or not, but mice share so many of the ailments that we do because we give them to 'em.
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It's like one of those terrible comic captions from The New Yorker.
I think, in an evolutionary sense, it would be more appropriate to say that humans got them from mice. Or, more accurate still, that they were present in the genome that mice were using and that humans eventually would eventually inherit.
Ah, forget it. We'll just chalk it up to Creationism and call it a day.
Type 1 PETA members probably already dead (Score:2, Insightful)
Re:Type 1 PETA members probably already dead (Score:5, Informative)
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At least it's not always 20 years away! (Score:4, Funny)
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Isn't that like saying that infinity+1 is bigger than infinity?
If it never materializes, then it never actually is there to help.
Re:Please...why do they report prematurely? (Score:5, Informative)
Re:Please...why do they report prematurely? (Score:5, Interesting)
It, along with Nature and Science, is one of the big three, the most respected
journals in most sciences. This does not guarantee against fraud but this is
not science by press release either. The other thing is that they talk of human
trials. Just to get approved for those you need buttload of evidence and it is
reviewed very thoroughly and it will be tested by many people, not just study
authors. Everything about this work seems proper, though once again there is no
real guarantee against fraud.
Mice (Score:2)
We've been down this path lots of times. It's great science. If it works in people, then it'll be great medicin
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My first thought was to buy shares in the company that will likely produce a drug. I even looked up the following paper:
Shawn Winer, Igor Astsaturov, Roger Gaedigk, Denise Hammond-McKibben, Marc Pilon, Aihua Song, Violetta Kubiak, Wolfram Karges, Enrico Arpaia, Colin McKerlie, Peter Zucker, Bhagirath Singh, and H.-Michael Dosch
ICA69null Nonobese Diabetic Mice Develop Diabetes, but Resist Disease Acceleration by Cyclophosphamide
J. Immunol., Jan 2002
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The latest (2006) article at
http://www.cell.com/content/article/abstract?uid=
mentions The Jackson Laboratory, but that is not appear to be traded.
Re:Please...why do they report prematurely? (Score:5, Interesting)
For me this is great news, my mother has been taking insulin shots for nearly 30 years. Recently animal based insulin products were removed from use, at least from the pool of what she has available. This wasn't some nefarious scheme of drug companies. It is because doctors perceived the new insulins to be better and easier to acquire. What is has led to is pure annoyance and even life threatening situations for many diabetics. Instead of two shots a days she was now in a regimen of 4 or more, using two different types; fast acting and slow acting. Even with multiple blood tests per day, watching what she was eating, she still went into conditions near death when her blood sugar either dropped into the teens or went over 500.
On a side note, bless my mother, she cannot recall my phone number all the time. She was alone at home as my father was away on a trip with friends and she had a bad reaction. She knew she was in trouble and managed to get some food down but passed out. When she awoke, very groggy and barely concious she managed to dial 911. The paradmedics could not enter the house as it was locked and they are not permitted to break down doors. She actually recalled my phone number and 911 contacted me. Needless to say I made a 10 minute trip in record time. Her blood sugar was in the low 20s when the Paramedics tested it. They would not even more her until they could get her stable. She was barely there. They actually had an ambulance on its way. Obviously she recovered.
Now because of this issue it was decided to put her on an insulin pump. A couple of people at work are also on the pump now, all for the same reason. It has become near impossible for some of them to regulate their blood sugar levels with the synthetics. So I look at a discovery like this as a near miracle. Hopefully the tests will prove out in a year or two. This type of discovery only happens because there are still people, working for either government, universities, and corporations, who defy common wisdom or by sheer luck stumble upon a whole new method.
While I don't know how much study was being done in this direction I can only hope it spurs others to investigate similar treatments for health problems considered to be nearly known is cause and scope. Its this openess to ideas that may just save us all one day.
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Re:Please...why do they report prematurely? (Score:4, Informative)
If you think that the paramedics & EMTs who come when you dial 9-1-1 should be able to break down the door, go find out what the law is in your area. In some states, I suspect they can break down doors. If your state doesn't let them, write to your legislators and governor asking for them to be granted that power.
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EMTs and paramedics are very different things. Paramedics are much more highly trained and empowered, and i
Premature (Score:2)
Re:Please...why do they report prematurely? (Score:4, Informative)
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Honestly, I do understand your complaint. A paper gets published by a grad student, or some joker who can't even get their PhD and is squeaking out a master's degree shows up at a poster session with a pile of photocopied papers and some newspaper reporter wandering through turns it into a wire st
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There was no premature report of anything. There was a peer-reviewed article published in Cell Thursday, 7 months after it was submitted. Human trials are likely to start in about a year. The Slashdot headline seems to be a complete invention of some idiot at Slashdot: nothing in the referenced National Post article or the actual Cell article says anything about human treatment (or any other milestone) in two years. If you think a Slashdot headline i
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In general, that's a fair viewpoint, but this may well be a BIG deal and very likely not in that class. Potentially, it may be more like Gerhard Domagk's discovery in 1932 that a dye called Prontosil (Sulfanilamide) could kill Streptococcus in vitro without (usually) killing the patient. Basically the sulfa drugs were the first dr
Well they do need to recoup their investment. (Score:2)
What's with every man Jack assuming he deserves the absolute best medicines and procedures for the lowest price?
"I wanted the Mercedes of healthcare, but I could only afford Kia!"
Kia makes a damn good cheap car tho.
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If they develop a full blown cure, or an injectable immunization system or whatever, you can bet it will cost a
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I am not a libertarian, but I am suspicious of demands that "those other people should be more self-sacrificing". Everybody complains about greedy drug companies, but except in rare cases, the folks complaining aren't taking 2nd jobs so they can donate the extra income to support medical research. It seems that it's somebody else's responsibility
Read the article (Score:2)
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Think about it. Even if you consider the extent of the problem, a "cure" of this magnitude, the potential is to be a once or twice a year (or less) application. Also, given the cost of maintenance, I would have to say a single injection will be in th $4000-5000 range. Wouldn't you pay it to be free of diabetes for a year?
Don't worry, I'm sure by the time it reaches the market, they will have engineered it to be a once daily pill, so it will appear much more affordable to the consumer. "Cure" is a dirty word in the pharmaceutical industry.
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The "two year" time frame quoted from the summary is just nonsense pulled out of somebody's nether end.
Nice article and for once, slashdot actually has something deeper than a blog for a reference. Now if the "editors" can just take thei
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Type 1 Diabetes is caused when the immune system attacks the islet cells in the pancreas. The islet cells are what produce insulin and when they shut down from the attack, your blood sugar levels rise. (Slowly at first, but at more islet cells are killed/incapacitated your glucose levels go steadily higher.) This can lead to circulation problems, blindness, and death among other things if not controled by injections of ins
Re:"suggesting the two illnesses are quite similar (Score:5, Informative)
RTFA - part of the big point here is that their research shows that this type of treatment cures BOTH types, indicating that contrary to what is believed, BOTH types have a similar cause, not just similar symptoms.
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Type 1 diabetes and Type 2 diabetes...
both type 1 and type 2 diabetes can cause three major types of complication
(1) macrovascular - stroke, ischemic heart disease, etc.
(2) microvascular - eye problem, kidney problem, etc.
(3) metabolic - high lipid, etc.
as for gestational diabetes, this is due to a high amount of insulin-antagonists (in a way) in the blood of a pregnant women. These women has up to 50% chance of developing diabetes (type II) later in life and this is related to the pregnancy 'exposing'
Re:Insurance In The US (Score:4, Informative)
Again with the conspiracy theories. Take off the damn tin foil. This is already a FDA approved treatment. Just this particular medical application is off-label. And the FDA isn't going to have much say in whether this is approved in Canada where the research is being done.
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I.e., insurance companies get paid more to cover diabetics than the extra cost of medicine, etc. for them, so that they're better off the more diabetics there are? (Even with the group health plans that many here in the US have through their employers?)
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The only thing this would help is reducing the progress of renal failure in those who are not end stage (i.e. those not on dialysis).