New Mad Cow Test on the Horizon? 184
pin_gween writes "Prions are thought to be responsible for mad cow disease and its human variant, Creutzfeld-Jakob disease. Until now, the only way to positively ID those infected was to dissect the brain. Canada.com has an AP wire reporting that researchers at the University of Texas Medical Branch at Galveston have 'developed a method of multiplying the number prions in a blood sample so a blood test then can detect them.' If perfected, it would make the blood supply safer; transfusions can spread the disease between people. It could also open up more blood donations for the Red Cross: in the U.S., people who have spent more than 3 months total (since 1980) in the UK or 6 months total (since 1980) in Europe are banned from donating."
Donation (Score:3, Interesting)
Re:Donation (Score:1)
Re:Donation (Score:2)
The UK however has had a lot more cases than other European countries. Other countries have been France, Belgium and the Netherlands, but to a lot lesser extent than the UK (probably about 90% of cases).
Re:Donation (Score:1)
Re:Donation (Score:4, Informative)
I know someone who is not allowed to donate blood in the USA. He has never been to europe. His grandfather died of CJD and contracted it in the United States. Becuase there is a possability he carried it when he has children and his grandchildren COULD have it. There is no way to test them. The only way they will know is when they get older they could get sick.
Re:Donation (Score:5, Insightful)
Pop quiz buddy. You are about to die. You need blood. You have a choice. DIE, or take the blood of a person who might, maybe, possibly, if 7,000,000,000 things went just right have a stray prion in his system, which might just might transfer to you and then 25 years from now cause you to die of nvCJD.
What do you choose. Death today, or death 25 years from now.
The policy is stupid. It kills people. The blood supply is severely strained as a result.
The definition of a rare blood type is not AB-, it is the type of blood you need when you need it and it is not there.
Less than 200 people have died of nvCJD in the world in the last 30 years.
Anyone worried about catching it and dying may as well shoot themselves right now, cause they are also worried to death about getting every other disease on the planet except for the ones that might actually kill them (like the flu).
GRRRR
Re:Donation (Score:2)
Re:Donation (Score:3, Informative)
So, here are some actual numbers, courtesy of the World Health Organisation [who.int]. As it turns out, you underestimated it, at least for the period in the report.
Still, it's worth pointing out that the UK population is in the region of 60million or so, so the number of cases is tiny.
Re:Donation (Score:2)
Quarantine seems to be working well for BSE, so infection rates are significantly different between different western nations.
Re:Donation (Score:3, Insightful)
Given the trend since, the British blood supply still looks immensely safe.
Re:Donation (Score:4, Insightful)
About 132 deaths over a 6 year period(not all are definite) , you have a far greater chance of the beef itself killing you by being stuck in your throat, slipping on a bit you spilled on the floor
Re:Donation (Score:2, Informative)
Re:Donation (Score:2, Interesting)
It isn't as if BSE is UK only, there are plenty of cases throughout Europe and the US as well - not on the same scale as the problem *was* over here, then again you didn't have pure evil corruption in government at the time. As an aside, I notice that BSE is occuring more often in the US these days
Re:Donation (Score:2)
A good example that the "free market" fundamentalists are wrong in not acknowledging that not everything under the sun works well just because it's a "free market solution".
The Conservative government under Thatcher is perhaps better described as free market radical. Actually, this is a trend seen in most European conservative
Re:Donation (Score:2)
Re: (Score:2)
Re:Donation (Score:2)
MOOooOOOOoooo
Mo!
Alternative test (Score:5, Funny)
Already exists (Score:2)
On a ligher note:
X-Bender: Oh, so, just 'cause a robot wants to kill humans that makes him a radical?
Did anyone else notice the X-* headers that slashdot returns? Funny.
Re:Alternative test (Score:2)
Look at her mom.
Mad Cow Test on the Horizon? (Score:2, Funny)
canadian cows maybe great but .... (Score:1, Insightful)
is there really no other way to make these tests than to kill innocent animals ? a hamster may be small but its still torturing and i'm ideologically against it. i wont go shout under their window with a sign in my hand but i definetly dont approve it. if we think it's normal to sacrifice one species animals for the sake of cheaper cow meat, what will keep the aliens from testing on us using our own behaviour as the excuse ?
i
Re:canadian cows maybe great but .... (Score:2, Insightful)
Re:canadian cows maybe great but .... (Score:2, Insightful)
ofcourse most of us dont give much thought about the rats/mice/hamsters used in the tests, and sometimes the sacrificing is just necessary to save the healthy animals/humans that have survived so far.
but i for example have a cat at home, i'd rather infect the biologist that wants to experiment himself than my kitten, no matter the purpose.
i guess most people with pets couldn't even think about giving their cats/dogs/birds for some animal testings now
Re:canadian cows maybe great but .... (Score:2)
Could you explain in more details? (Score:2)
To be fair (Score:4, Funny)
Re:To be fair (Score:2, Interesting)
Re:To be fair (Score:2)
The prion has to come into contact with the normal protien to replicate and it's effectiveness depends on the specific structure of both. Since different spi
Re:To be fair (Score:2)
Which, of course, is what started the latest outbreak of mad cow disease to begin with. Domesticated ruminant animals are not, by their nature, cannibals. Human greed overturned common sense when we started putting bovine blood and bone meal in animal foodstock as "suppliments".
Re:To be fair (Score:2, Insightful)
Instead, we will just test for the disease, hoping to eliminate diseased cattle from the food supply.
Why try an ounce of prevention when we can spend more on the pound of cure?
Sure you want to know the answer? (Score:2)
Blood test since 2003 (Score:4, Informative)
Re:Blood test since 2003 (Score:3, Insightful)
If it was just an unfortunate phrase, then i'm sorry that i'm still talking about it, i just wanted to make sure it gets corrected.
Re:Blood test since 2003 (Score:2)
Re:Blood test since 2003 (Score:2)
Re:Blood test since 2003 (Score:2)
Re:Blood test since 2003 (Score:2)
You are precisely correct in that vCJD is thought to be caused by injesting BSE contaminated meat whereas CJD is classified as either inherited or 'sporatic' - i.e., no known cause or risk factor.
BSE is thought to be a Transmissable Spongiform Encephalopathy (TSE) where CJD is not known to be transmissable unless the victom is eaten - as the disease Kuru is/was in cannibals who ate the brains of their
Re:Blood test since 2003 (Score:2)
heard this on the TV a while ago... (Score:5, Funny)
cow2: Why should I? I'm a rabbit.
I hope they don't expect a lot more donors (Score:4, Insightful)
So with over 80% of Americans not even having a passport [gyford.com], is that really a problem?
Re:I hope they don't expect a lot more donors (Score:3, Interesting)
I worked at the Red Cross for a number of years and by far the least pleasant duty I had to perform was explaining to perfectly healthy people, whose blood was also probably perfectly healthy, that they couldn't donate beca
Re:I hope they don't expect a lot more donors (Score:3, Interesting)
Re:I hope they don't expect a lot more donors (Score:5, Informative)
Remember, this blood will go to sick or injured people that aren't in the right shape to have to worry about what drugs or viruses are in their bloodstreams, and how they'll react with what they're already on.
Re:I hope they don't expect a lot more donors (Score:2, Interesting)
As a regular donor, I concur with this. It is extremely frustrating to be turned away (temporarily) for some of the most absurd reasons, especially if it's after they've already poked your finger.
My favorite reason was that I went to Nayarita, a state in Mexico with a "malaria risk." The fun part is, I was only 5 miles across the border into the region (from Jalisco, which is "safe") and I stayed on the beach and out of the jungle. As a result, I could not give blood. (This is despite the fact that I had b
Re:I hope they don't expect a lot more donors (Score:2, Informative)
Armed forces (Score:2)
With this live subject testing possibility it becomes possible to determine the real impact of BSE/vCJD on the cow and human population. There have been estimates in the past of several 100000 british who will eventually die from this disease. Now they can verify that number (and create relief/cause wide spread panic while they are at it anyway)
cost and time (Score:3, Insightful)
Cost effectiveness... (Score:2)
Will this test work on
There is also another test... (Score:3, Informative)
Mad Cow and CFD is a hype - it is safe. (Score:2, Interesting)
Read one of the last chapters in the Matt Ridley book "Genome - the mapping of a species".
The facts are
1) To be able to get CFD, you need to have a genetic defect, making you suspectible to prions. If you don't have that genetic defect, you can eat 100 fresh non-cooked brains of mad cows and never get CFD.
2) The risk of getting struck by the disease, if you have the genetic defect, is something
Re:Mad Cow and CFD is a hype - it is safe. (Score:5, Informative)
"The facts are..."
"+1 interesting" as it may be, from that point on the parent was utterly wrong.
Some definitions: TSE is the general name of the TYPE of disease. Bovine Spongiform Encephalitis (BSE), or "Mad Cow's Disease", is the specific name of the disease as it appears in bovine, or cows. Creutzfeldt-Jakob (CJD) disease is the specific name of the disease at it appears in people.
Some common points of confusion:
-Grym
Re:Start by checking your own "facts" (Score:2)
To me, the deprecation would seem unnecessary. The "new" variant only needs to be newer than the old one, unless an even newer variant has come along since then.
Re:Start by checking your own "facts" (Score:2)
You're right. Serves me right for posting minutes before class.
vCJD, varient CJD is also known as new varient CJD or nvCJD. That's where that n came from.
-Grym
Re:Mad Cow and CFD is a hype - it is safe. (Score:2, Informative)
I hope this is true, but the figures from the CJD observation unit don't back it up. http://www.cjd.ed.ac.uk/figures.htm [ed.ac.uk]
Since 1990 the number of deaths from definite or probable vCJD is 150.
This is for the UK only (not the whole of Europe), is a figure for deaths rather than just cases and for a period of much less than 50 years.
Amazing (Score:3, Interesting)
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
http://www.who.int/mediacentre/factsheets/fs180/en
So the world incidence rate over the period spanning 1996-2002 was 1 in 35,971,223(assuming the world population of 5,000,000,000)
The risk in the UK was roughly (assuming a population of 60 million) was 1 in 465
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
The symptoms of CJD are close enough to alzheimers that some percentage of alzheimers patients could easily have had CJD and were simply never tested posthumously. Then there are people who may have contracted CJD but died before manifesting any symptoms. The numbers could easily be scarier than are reported.
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
Missing Poll Option: vegetarian (Score:2)
Re:Missing Poll Option: vegetarian (Score:2)
Perhaps [bbc.co.uk], but cutting it a bit fine.
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
It's not BSE and CJD that are scary. It is the concept of chain reaction protein warping. Since most (or all) of my biological processes depend at some point on proteins, I'm rather fond of keeping their configuration exactly the way they are.
Prions are conceivably the nanotech nightmare of grey ooze... a wave of mechanical transformati
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
You can see this effect in reverse with women athletes in reverse where if their body fat level is low enough they cease menstruation.
Specifically, a lot of hormones are derivatives of chole
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
There is an extensive bibliography but he lists three works in particular:
1. Rosalind Ridley and Harry Baker, Fatal Protein (Oxford University Press, 1998)
2. Richard
Re:Mad Cow and CFD is a hype - it is safe. (Score:2)
Tough work (Score:4, Interesting)
I have a friend who worked in a lab that was trying to develop a test for MCD, and my hat goes off to the people who do this kind of work.
Since so little is known about the exact infection process, known infected brain samples have to be handled -very- carefully. Working in a high-level biohazard environment is not easy, and is very stressful.
Banned (Score:5, Insightful)
Re:Banned (Score:3, Informative)
Re:Banned (Score:2)
Re:Banned (Score:2, Interesting)
The answer is very probably. http://news.bbc.co.uk/1/hi/health/4699349.stm [bbc.co.uk]
Re:Banned (Score:2, Informative)
Re:Banned (Score:2)
I agree. People make value judgements about surgery with the assumption that a blood transfusion is safe, or at least as safe as we can make it. Changing that would require a re-appraisal of risk across the board by doctors and patients. I know that the blood supply is perennially low, but I think the current balance is about right (and I do donate blood).
One of my children had
Just wait (Score:2)
Re:Banned (Score:2)
Right (Score:2)
And everyone always tells the truth.
And the tooth fairy leaves money under your pillow in exchange for your teeth.
VCJD in the US (Score:2, Funny)
not occur within the states, mainly because
it is a federal offence to even mention the
possiblity of it
I ask you what is safer, wipe out the disease
or discussion (and therefore action).
Jacqui
eat steak eat steak (Score:3, Interesting)
Not sure if that was intentional or not but it was a bit disturbing.
Donation Bans: Poster is Wrong (Score:4, Informative)
Re:Donation Bans: Poster is Wrong (Score:5, Informative)
It used to be. They've relaxed it recently. (I know, because I was trying to figure out why there was the ban, as I'm in the group banned, and freaked me out even more when the relaxed the rules, but I was still in the banned group.)
Here's the notice they've been sending out whenever we have a blood drive at work:
Re:Donation Bans: Poster is Wrong (Score:2)
Furth
Oh my, yes (Score:3, Funny)
Am I the only one who imagined Professor Farnsworth saying that, with a degree of relish?
Re:Oh my, yes (Score:2)
Farnsworth: Some sort yes. In France it's called a "guillotine."
[He pulls a lever. Leela gasps and jumps out of the way, narrowly missing the blade.]
Leela: Professor! Can't you examine my brain without removing it?
Farnsworth: Yes. Easily.
[Futurama 4:12]
Actually... (Score:2, Funny)
http://www.cybersalt.org/cleanlaugh/madcow.htm [cybersalt.org]
No tech needed... (Score:2, Funny)
If you tip a cow, and it gets up and charges you.. chances are it's mad.
</dumb joke>
Mad Cow Test (Score:2, Funny)
Heartbeat Test for BSE (Score:2)
BSE breakthrough as heartbeat test reveals first symptoms [guardian.co.uk]
"When an animal is infected with prions, its heart rate becomes more variable. All you have to do is take five minutes' worth of electrocardiograms and feed these into a laptop computer fitted with special software. Within seconds, it can tell you if you are dealing with an infected animal or not.'"
a different Mad Cow theory (Score:3, Interesting)
Executive summary:
In the early-80's, there was a warble fly epidemic in the british cow fleet. Warble flys punch holes in cow hides, making them unsuitable for high-quality leather products. In their infinite wisdom, the british government decided that all british cows needed to be treated with a pesticide that kills warble flies.
The pesticide was a synthetic organo-phosphate (an oily concoction), that was applied along the spine of the cow. Not only did it kill warble flies, it also chelated (removed) copper from the cow's system.
Then in 1986, chernobyl went off, blanketing the countryside with radioactive isotopes. Copper-deficient cows picked up some of these radioactive minerals to replace the copper they'd lost to the pesticide.
There's also something about manganese (commonly used in textile manufacturing) substituting for copper.
As an organic farmer, Mark Purdey had no intention of using a synthetic pesticide on his cows. So he sued, and was allowed an exemption to using this pesticide. He's never had a mad cow, not even amoung his cows who are reformed carnivores, so he must be doing something right.
Much more information on his website.
Mad About Cattle (Score:2)
Re:Mad About Cattle (Score:2)
Re:Mad About Cattle (Score:2)
Evidence for Relationship with BSE (Mad Cow Disease)
Since 1996, evidence has been increasing for a causal relationship between ongoing outbreaks in Europe of a disease in cattle, called bovine spongiform encephalopathy (BSE, or 'mad cow' disease), and vCJD. there is now strong scientific evidence that the agent responsible for the outbreak of prion disease in cows, BSE, is the same agent responsible for the outbreak of vCJD in humans.
Re:Mad About Cattle (Score:2)
Re:Mad About Cattle (Score:2)
Re:Mad About Cattle (Score:2)
Mad Cow (Score:2)
Just what we need - more prions (Score:2)
Re:Just what we need - more prions (Score:2)
I just hope they don't pour the blood tests down the drain. Even routine medical waste disposal procedures probably aren't adequate.
John.... (Score:2)
Re:bummer (Score:2)
Re:bummer (Score:2)
It used to be limited to 6 months in Europe, but now it's actually 5 years (still 3 months for the UK though). I know this because for a while I wasn't allowed to donate blood having lived in Germany for 2 years, but I recently noticed a change in policy on the Red Cross website. The questionaires and everything are even changed and I had
Re:Was Lance Armstrong mad cow positive in '99? (Score:2)
PS: I'm not French nor do i hate Americans so keep that BS before you. Thanks.