Patents and Open Source Biotech 164
sebFlyte writes "Since Slashdot readers seem to be interesting in the issues and problems surrounding software patents, I thought they might be interested to see that Wired is running an interesting piece on patents in Biotech and the way that they can hold up important research, and how there are clear parallels with the open source software community with the way that advocates of openness are trying to solve these problems."
Nice linking (Score:5, Informative)
biotch? (Score:2, Funny)
word
Re:biotch? (Score:2)
Re:biotch? (Score:2)
Re:biotch? (Score:2)
Re:biotch? (Score:1)
Re:biotch? (Score:2)
Haha.. I'm glad I'm not the only one. I don't think I've ever misread biotech that way. Must be my low expectations for slashdot.
Re:biotch? (Score:1)
Re:biotch? (Score:1)
me too!
Simple solution ... (Score:5, Insightful)
For those who whine, "But then there won't be any incentive to innovate!"
If the suits want to make a profit, they'll have to work a little harder to figure out how. Watch me weep in sympathy.
Re:Simple solution ... (Score:4, Interesting)
Re:Simple solution ... (Score:3, Insightful)
Understanding requires money, manpower, and specialized resources. We are far past the days when a man like Pasteur could make a significant advance on his own.
The Gates Foundation alone has spend over $100 million researching AIDS.
If someone discovers a way to cure me, or augment me, or terrorize the living hell out of me I don't want that technique monopolized.
But you will take the cur
Re:Simple solution ... (Score:2)
What they spend money on are the treatments. That's where the patents really pay off. And even there they save their best treatments until the patents on the lesser ones run out in 5, I mean, 10, I mean 15, years. Only government sponsored or academic researchers work on cures. And the
Re:Simple solution ... (Score:2)
Re:Simple solution ... (Score:2)
This is not something that these companies hide. They openly admit it. All you have to do is ask them. They are in business to make money, not to save the world. That is not their
Re:Simple solution ... (Score:2)
This is true, but it is a vicious circle. The cost of research has skyrocketed exactly because every research activity involves paying some bio-supplies company for patented materials and techniques. If a lab needs (say) $100000 per year to do serious research, they will patent/sell anything they can so that they can survive. Scientists themselve
Re:Simple solution ... (Score:2)
The traditional Hippocratic Oath [pbs.org] defined the responsibilites of the healer and a system of practice something like a medieval guild, in which medical knowledge is transmitted from father to son and other male apprentices. It did not require you to offer your services for free and offers no guidance on how to organize and fund research, development and
Re:Simple solution ... (Score:5, Insightful)
Re:Simple solution ... (Score:3, Interesting)
This goes double for industry. You invent something, the company patents it. You might be the inventor, but the company is the assignee. It is their patent to do with what they please. I have patents in a mixture of software and biology. Where I work, and I assume it is pretty much the same in most places, if the company wants to patent it, you have no choice. I am not against patents, but if you work for a corporation and they want to patent
Re:Simple solution ... (Score:3, Insightful)
Re:Simple solution ... (Score:2, Funny)
Same here. Unfortunately, the money is limited (although, where it is going to besides the public good is a whole other can of worms). I think that if we want more basic research funded (by the people and the corporations) the answer is to get better PR. This is what the APS (American Physical Society) is trying to do this year by promoting 2005 as the " World Year of Physics [physics2005.org]".
damn it, they should just pay us for being brilliant.
Kn
Re:Simple solution ... (Score:5, Insightful)
But that's different than having to worry about whether your research infringes on a patent. I think what the parent post meant was that biologists and scientists in general don't want to keep their research closed and patented in order to make money themselves (Funny how the patent pushers go on about needing patents to provide incentive and progression when scientists know that science has to be open to flourish). I guess a tough situation could arise when your funding agency or university is insisting that you get a patent when you know it will be a hindrince to your field.
So maybe there should be a law. Absolutely no patents in general blue sky research. And if that lowers funding and slows down resarch, well it won't slow it down as much as this patent problem could.
Only in some sick bizzaro world can I imagine having to stop my research because it infinged on a patent, but it actually happened to a professor at my uni. He does geological resarch and was using a method of determining the density of earth at very low depths. He uses it for basic 'what is the earth made of and what's it doing' type research, but apparently some company that prospects for oil had a very vague patent on the general method and is now trying to stop him from doing his research.
What a hateful thing
So I agree with you that big money and even big corporations sometimes have to be involved. I just wish patents weren't.
living systems and their components (Score:2, Interesting)
Is a Virus living?
What about bacteria?
What about the single protein that causes CJD?
What about a pint of beer, or some new way of making a plastic that uses designer bacteria in the process.
Re:living systems and their components (Score:3, Insightful)
Viruses: maybe, maybe not, but close enough for legal purposes.
Bacteria: clearly yes.
Prions (self-reproducing proteins, such as the presumed causative agent for CJD): um, er
Pint of beer, plastic, etc.: no, and I don't have any problem with anyone patenting a specific formulation of beer or plastic or anything else. It's the yeast, bacteria, or even individual genes used in the process that IMO should be off
Re:living systems and their components (Score:2)
If you want to draw a line between the patentable and the unpatentable, then come
Re:living systems and their components (Score:2)
No. A virus requires a cell to replicate in. A biologist would probably say the cell is the basic unit of life.
No the question is what do you mean as a 'component' of life? All organic compounds? Well, many organics are synthesized in the lab these days. Polyethylene is and organic compound. As is acetic acid, all alcohols, etc.
Clearly 'component' of life is going to be very hard to define.
Re:living systems and their components (Score:3, Insightful)
Viruses fail several of these criterea.
Viruses don't reproduce. The mechanism for virus duplication involves the cell replicating the virus. Also viruses do not grow, they remain the same size as they were created for their entire life cycle. Viruses do not consume anything either - they have no metabolic cycle. No ingestion of food or excretion of waste.
Re:living systems and their components (Score:2)
Actually, I find it hard to say that a virus does any those things. Let's look at those in order. A virus...
Re:living systems and their components (Score:2)
The human immune system "kills" many things that enter our bodies. However, I certainly wouldn't consider all of them to be "alive". I had a bad splinter once. My immune system attacked it as a foreign object. However, I wouldn't consider a piece of wood "alive". There has been many things that entered my body that my immune system "killed", that doesn't mean t
Re:living systems and their components (Score:2)
Re:Simple solution ... (Score:1)
2. A man must use his mind in order to survive.
Since survival is the process of maintaining life, it follows from these that a man must have the right to the products of his mind - the right to own property. The products of his mind are both material, likeusing his skills to produce goods, and non-material, such as discovering a useful new process in biotech.
The rightful purpose of the government is to prot
Re:Simple solution ... (Score:1)
I'd like to file a patent please. Yes, It's: "A mechanism composed of organic matter that hunts its own food, reproduces, responds to stimulus, and adapts to stimulus."
Re:Simple solution ... (Score:4, Insightful)
So must a lion.
Since survival is the process of maintaining life, it follows from these that a man must have the right to the products of his mind - the right to own property.
This is what is known as a logical leap. Why must ownership of ideas be *exclusive*, as the parent seems to suggest (i.e. if I own an idea, you can't own the same one)? Ideas are not like diamonds; the replacement cost of sharing an idea is nil.
If you deny that men can own their ideas, then you deny that men can survive by ideas, and you deny the right of man to survive at all.
Last I checked, no lion owned a patent for "How to identify, kill, and eat aged wildebeasts," and yet somehow they are able to implement said concept and survive. Curious.
Patent and copyrights represent a pragmatic balance of power between creators and consumers, nothing more, nothing less. To the extent that they inhibit creators for borrowing from existing ideas, they can be problematic.
There are no first-principle metaphysical requirements for ownership of ideas to be exclusive, as the parent suggests.
Re:Simple solution ... (Score:2)
This is also true for the lion. Make a few choice incisions in the lion's brain (yes he does have one, and it looks much like ours) and he will not be able to hunt anymore. All animals need to "reason", to think, to use logic in some way. The use of "instinct" to somehow explain all of "lower" animal behavior has been discredited for a long time now.
It certainly seems to be true that humans have certain intellectual abilities that lions do not, but that on
Re:Simple solution ... (Score:2)
Quite wrong.
You appear to claim that no one can rightfully compel another person to do or not do something. A patent is nothing other than the right to compel other people to not do something (it is not a right to do something oneself, btw).
Patent rights are not natural rights inherent to man. They're artificial, created consensually by society to serve the interests of society, and are shaped in terms of their vesting, sco
Re:Simple solution ... (Score:2)
You've completely misunderstood the point of patents. The point of patents is not to let someone own their own ideas, the point is to deny everyone else the right to _their_ own ideas.
So, how does your philosophy justify someone denying someone else the right to have his own ideas?
Comment removed (Score:4, Informative)
Re:Simple solution ... (Score:3, Informative)
It isn't going to happen.
The first U.S. plant patents were granted in 1930, sixteen patents were awarded posthumously to Luther Burbank, 1849-1926, the 10,000th plant patent was granted in 1997. Today in Science History [todayinsci.com]
Burpee was commercially developing hybrid plant and animal stocks as early as 1876, only ten years after Mendel gave selective breeding a scientific basis.
Re:Simple solution ... (Score:5, Interesting)
So how do you let them protect their investment? The detection processes are already patented (we license them, at a cost of another bazillion dollars a year.) They can't patent the poop itself-- everyone's is different. So they patented the structure of the detectable fragments. Did they invent the fragment itself? Of course not, the cancer cells did. But they made these particular fragments incredibly valuable, in one particular context.
Do these patents prevent someone else from discovering another, equally detectable fragment? No. All it does is protect the company's investment in R&D, while still allowing them to provide a reasonable profit while providing a valuable service.
If it weren't possible to patent such things, this research would never have been done. And believe me, if you've ever had a colonoscopy, you'd be damned pleased that an alternate technology exists.
Re:Simple solution ... (Score:2)
Don't be so sure. With the USPTO and a good patent attorney I'd give it a 1 in 10 shot. Even with all the prior art.
Re:Simple solution ... (Score:2)
Colonoscopies take time and money, and colon cancer kills taxpayers. As it is cheaper and more resource effective to use tests on feces, it would be in the interest of both taxpayers and insurance companies to fund such research.
As it then would not be patented, it would be cheap enough for MrMuscle to add it to their toiletbowl fresheners, indicating possible colon cancer by color marking the toilet water and almost
Re:Simple solution ... (Score:2)
Won't they find it hard to do their jobs if, due to the inability to patent any outcome, the company eliminates said job?
It's more than just a little disingenuous to claim that the scientists are independent of "moneymen." We all need to make a living.
I do private experimentation at home on my own time, on my own dollar, but I still need a job so I have the money to buy equipment.
Re:Simple solution ... (Score:1)
Take the Hapmap project. They're aiming for 5,000,000 variants x 300 people. At a low price of say...$0.05 cents each, that's low low price of $75,000,000. The good thing is that the technology costs are going down, so they'll probably finish the whole project for closer to $50M. That doesn't count all the human labor costs, just the reagents.
What's cool is that this is essentially an
On a related note: (Score:4, Interesting)
Biotech patent? (Score:1)
Re:Biotech patent? (Score:2)
Re:Biotech patent? (Score:1)
So plant regular corn or soybeans.
Re:Biotech patent? (Score:2)
Re:Biotech patent? (Score:2)
Same thing happening in film/media (Score:5, Informative)
Is copyright killing culture? [theglobeandmail.com] Some documentary filmmakers certainly think so [centerforsocialmedia.org].
Ho hum (Score:5, Insightful)
Interestingly, you can download sizable chunks of the gene sequences for cows, chickens, humans, the SARS virus... Clearly, the researchers who have made such information available are Communists, for not protecting their IP rights and demanding the first-born from all who would see such information.
Pathetic. The bulk of serious research is done in an open environment. If you want to see quality, verifiable, useful information, you don't look in the patent office. You look up the research papers that have been published and are either freely available or damn cheap.
To the best of my knowledge, the only person known to have successfully learned something from patents was Einstein. But if you look at his best work, you look at the thought experiments, the observations of the ordinary, the stuff that is simply not ownable. THAT is where Real Science and Real R&D takes place.
Re:Ho hum (Score:2)
Go look at a U.S. patent, any one, and look under the section called "references cited" -- there you will see a bunch of other patents that the current patent is "built upon."
I guess you could be cynical and say that those references are only listed so that the patent owner can later avoid an inequitable conduct charge, and to basically take those patents out of contention in the case some
Re:Ho hum (Score:3, Informative)
No, there aren't. Genetic patents cover the gene PLUS some use of the gene.
ssentially is a ban on evolution.
You have no clue.
The bulk of serious research is done in an open environment.
Do you realize what a patent requires you to do? You have to publish your results in order to be granted a patent. Anyone can download your patent and us the results for further reasearch. Without the patent the researcher would have NO incentive to patent.
To t
Re:Ho hum (Score:2)
You can tell me to learn about patents, but you have much to learn about history.
Re:Ho hum (Score:2)
There is an experimental use exemption in US patent case law. So long as you don't intend to made money from the work, you can do any R&D you want and be immune from infringement claims.
REAL researchers publish, rather than patent
Have you ever been a researcher? If you had, you would know that just about all researchers file patents before they publish these days. Universities are making so much money from patent licensing that there is no place you can work that doesn't require y
Re:Ho hum (Score:2)
So I guess I know the scene pretty well. I've never patented any work I've done, nor has anyone else I've worked with, to the best of my know
Re:Ho hum (Score:2)
If you had, you would know that just about all researchers file patents before they publish these days.
LOL! Thank you for the best laugh I've had all day.
With some honorable exceptions patents are actually a pretty good indication that the research is of little value. Most good researchers avoid patented areas like the plague. Lawyers and the patent office have an extremely biased view of the research community. Mostly, the only researchers they see are the ladder climbers who don't give a shit about th
Re:Ho hum (Score:2)
Geez. Of course they do. Most researchers are trying to do original work. Duh.
The "experimental use exception" you mention is useless
Nah. It's a key provision of patent case law. Established by a Supreme Court decision in 1813 from what I remember.
In addition patent boosters tend to forget that quality research requires the free exchange of ideas. The paperwork and lawyers associated with patents pretty much stops that cold.
Bzzzzrt. Patent
Re:Einstein (Score:2)
Much the same could be said of Newton's/Descarte's Laws of Motion. The thinking was novel, but the constructs were very basic.
About the biggest reason the ancient Greeks didn't have all of the above, two thousand years ago, was that they weren't
Ugh, don't get me started on patents (Score:2)
My example is poor because genes that influence alzheimers have been found already, but it'
Re:Ugh, don't get me started on patents (Score:1)
Re:Ugh, don't get me started on patents (Score:2)
Not just a possibility it is happening [commonground.ca].
Re:Ugh, don't get me started on patents (Score:2)
Nobody has been able to show me a case where Monsanto has gone after a farmer after it was shown the contamination was accidental. It just hasn't happened, and is one of those urban legends that the anti-GMO crowd is using, falsely.
Re:Ugh, don't get me started on patents (Score:2)
Re:Ugh, don't get me started on patents (Score:2)
DNA is an acid. (Score:1, Interesting)
Chemicals cannot be patented.
What's going on here?
What am I missing?
Re:DNA is an acid. (Score:5, Informative)
that's not true. (Score:1)
Re:that's not true. (Score:2)
Blockbuster drugs earn millions of dollars PER DAY. Patent applications cost $10k or so. Trust me, they patent EVERYTHING. That way when some patent is lost on a technicality the company doesn't lose
Re:DNA is an acid. (Score:2)
Recipes aren't copyrightable either.
Re:DNA is an acid. (Score:2)
Wrong. Mixtures certainly are patentable so long as you can show they have novel properties.
Just because something isn't patented doesn't mean it can't be. In the case of Coke patenting the formula would be a dumb move since the duration of patent coverage is only 20 years. After that 20 years anyone could use the same formula. Trade secret protection has no time limit.
Re:DNA is an acid. (Score:2)
Is 'light, crisp, refreshing' taste (I'm looking at a diet Pepsi can here) a novel property?
I guess I should have been more clear -- maybe you could, in principle, patent a soda recipe -- but how would you show that it has novel properties (beyond what you would expect a soda to have) and that it was nonobvious to one "skilled in the art?"
"Just because something isn't patented doesn't mean it can't be."
Very true.
Re:DNA is an acid. (Score:2)
Is 'light, crisp, refreshing' taste (I'm looking at a diet Pepsi can here) a novel property?
Maybe, if you can show that it was unexpected or stronger than anticipated (insert your anticipation here) or whatever given the ingredients. And always remember it's ORDINARY skill in the art.
how would you show that it has novel properties (beyond what you would expect a soda to have) and that it was nonobvious to one "skilled in the art?"
When all else failed strawman comparisons with other formulations have
Re:DNA is an acid. (Score:2)
Re:DNA is an acid. (Score:2)
Chemicals are essentially mentioned explicitly in the law as an invention patentable. Of course, a new DNA sequence isn't really a new composition of matter, although most things you can do with DNA involve the production of chemicals which might be new.
Re:DNA is an acid. (Score:3, Informative)
Dude, my grandfather is a chemical engineer and has 60+ patents. Whiteners, that ink-impregnated paper that replaced carbon paper, etc.
Re:DNA is an acid. (Score:2)
Wrong. Some of the most famous of all patents are on chemicals. Teflon for example.
The Patent Office is moving to use exactly the same guidelines for patenting genes as they use for all other chemicals.
Re:DNA is an acid. (Score:2)
Just my attempt to be informative:
The USPTO will continue to apply existing case law until an application is denied and taken to the Patent Board of Appeals or an issued patent is litigated and appealed to a higher court, whereby proper procedure (from board of appeals) or new case law (from appeals court) tells the USPTO that the old case law is inappropriate.
I've drawn plenty of ire a
Why is the Prez blocking funding on stem cells... (Score:2, Offtopic)
Seems to me, we're putting money into public research that feeds private pockets in an unfair way...
Is the prez just trying to promote his religion in the guise of conservatism?
I don'
SUMMARY OF PROPER /. GROUPTHINK (Score:2, Insightful)
Unless I wrote or invented it.
Re:SUMMARY OF PROPER /. GROUPTHINK (Score:2)
I suspect (though am prepared to be proved wrong), that much of the "groupthink" is based around a few simple principles:
Re:SUMMARY OF PROPER /. GROUPTHINK (Score:2)
On this issue... (Score:1)
Only problem with this story: (Score:1)
Your money or your life (Score:2)
What am I missing here? (Score:5, Interesting)
BIOS will soon launch an open-source platform that promises to free up rights to patented DNA sequences and the methods needed to manipulate biological material.
I thought you can't patent DNA sequences, only processes on sequences. Gene patents without specific purposes were thrown out years ago, weren't they?
I understand why methods are being patented. They are costly to develop. They aren't obvious. Without patents, I'm not sure what the desire is to invent a new method to cheaply assay something.
My work uses data very similar to sequence data (genotype data), and the data gathering process has become a commodity over the last few years. Everyone's developed their own machines, methodologies, and patents. You can sign up with any of these guys, and essentially the bottom line is: cents / data point. You weight that in against the size of the batches you're planning on doing over the next number of years, the reliability and service provided by the company's platform, and go.
These companies would not be innovating newer, cheaper solutions if I could just take those solutions back to the lab and they didn't earn a penny for their effort. As it is, these companies are working on slim margins, and not many of the startups are successful.
In the past, before these companies came out with their turnkey solutions, we'd have to roll our own. And that means detection systems, possibly robots, databases, protocols for chemical processes, etc.
When I worked in the lab, we did one of these, based on a paper that was published in 1999. Even standing on the back of another researcher, it took us 18 months to have a working assay system that was 'production ready' for JUST OUR LAB (granted, it's the MIT genome center, and we're a big-ass lab.) Just about the time we finished, the first decent turn key solution came out...and it was cheaper and easier than what we'd developed.
I love what I do for a living. It's a good time, and interesting work. Would I do it for free, if I had to work a normal job?
No way. This job alone takes huge amounts of time, outside research, etc to excel. If I wasn't compensated for my hard work, I'd have no time to *do* that hard work.
(given all that, we're working on open-sourcing chunks of our source code, to at least give something back to the community - but source code is the least of our assets.)
You are missing a lot... (Score:2)
First, noone said that scientists shouldn't be paid or even whether there should be a profit motive - that's an entire straw man - the question is whether the advancement of science is hindered or helped by the presence of patents. I would argue that patents hinder biotech and also that you can make money without patents - you just have be more clever than being the first to stake out your claim.
Let us take a look at your example - your assay procedure.
Patenting genes is a bizarre form of capitalism (Score:1)
Re:Patenting genes is a bizarre form of capitalism (Score:2)
Re:Patenting genes is a bizarre form of capitalism (Score:2)
Columbus claimed a hereditary governorship of the new western territories under the terms of the agreement with his Spanish sponsors. That fell apart when the true dimensions of his discoveries became apparent.
DNA patent enforcement (Score:2, Funny)
Editors cut out the last bit of submission (Score:3, Funny)
sebFlyte continued:
It's very interesting. I'm interested to see what interesting direcitons may be taken if these patent holders are interested in furthuring this interesting branch of research for the good of humanity.
(all in good fun)
free for academic purposes? (Score:1)
This whole patent business often make me doubt democracy where the representatives are betraying or failing us (the people) while the people (exept us?) don't notice...
open source biotech already exists... sort of (Score:2, Insightful)
its true that the US congress has gone a bit far in extending patent rights (first drugs had 5 year patents, then 10, and now some have 15 years). this has created high drug prices an
Headline as read by me (Score:2)
Patents and communism (Score:2)
Just another gentle reminder that Open Source is indeed communist at its heart and that the principles of open scientific research, libre software and communism are generally the same.
Another quote:
OnTopic, surely? (Score:1)
Re:BIIIOOOOTECH... BIIIIIIOOOOTECHH (Score:2)
Re:BIIIOOOOTECH... BIIIIIIOOOOTECHH (Score:2)
Re:You people are fucking idiots (Score:2)
No need to get vulgar. To the pharma corps CURE is indeed a 4 letter word. One they don't want to touch no matter how long the patents. What good does even a 20 year patent do them when everyone with the disease is cured within a couple of years? How will they pay for all of their research? And don't even mention the word VACCINE. God. Talk about a waste of their time.
So do me a favor. Next time use