Blending Mice and Men 387
An anonymous reader sends in this piece about chimeras - not the ones with a THAC0 of 11, but a more general term meaning any multi-creature hybrid. A comprehensive look at the moral and scientific issues surrounding this area of biotech.
THAC0? (Score:3, Informative)
Re:THAC0? (Score:5, Informative)
Seriously mods (Score:2)
LK
Non-layable (Score:3, Funny)
Well, I take that back. If their freekitude makes them rich, then the babes will probably come.
For every freak.. (Score:2, Funny)
Re:For every freak.. (Score:4, Funny)
Yup, especially considering how famous the Triple Breasted Whore of Eroticon Six was
Re:Non-layable (Score:2, Insightful)
Re:Non-layable (Score:2, Funny)
In that regard, how do they differ from the typical Slashdot reader?
(I fully include myself in that category, so don't be offended.)
Re:Ahem... (Score:2)
Ewww is all I can say.
They've been around for a while... (Score:5, Interesting)
They've been around 3 billion years or so (Score:5, Interesting)
Ok, maybe they're not chimeras in the sense of two radically different lifeforms, but the article considered a mother carrying DNA in their blood from their child as being close enough, so I think it's OK to consider any lifeform in which there are two or more non-identical DNA sequences present.
DNA is horribly unstable stuff. That's why mutations occur. It's also why certain cancers occur. All it takes is for a cell's DNA to be altered. A bad copy, a reaction with a free radical, whatever. What you get is a cell with different DNA than other cells.
99% of the time, that's not a problem. The cell destroys itself or gets destroyed by the body's defenses. No big deal. Some of the remaining time, the cell goes cancerous. Either the cancer or the organism is destroyed.
Most of the remaining incidents would likely be chimeras of a kind, especially if the organism is still developing. There's absolutely nothing to stop a cell mutating subtly and then copying that mutation into every copy of that cell ever made. If it's a useful mutation (it can survive and it confers an advantage) AND it occurs early enough in life that descendents acquire that mutation, we call it evolution. But I can think of absolutely no reason why a useful mutation cannot occur at any time in an organism's lifetime. It's just going to be rather more regional and it probably wouldn't be conferred to descendents.
Although much less likely than a single cell mutating, I can see absolutely no reason why it would be impossible for multiple cells to mutate in a way that would (a) individually function and (b) function together as a single organism.
Exposed to an environment that is sufficiently hostile to DNA, there is a non-zero probability of just about any imaginable set of mutations occuring. This creates an interesting philosophical problem. There's a lot of debate as to when human life begins. But by the arguments given above, there is a non-zero probability that any life could be human, and a (much higher) probability that any human is not entirely human.
If cells can mutate, blend, fuse, do whatever cells like doing on weekends, etc, then is it meaningful to consider how human a chimera is? We must all be chimeras. It's just a matter of degree.
"Human" cannot, then, be the state of an organism, because no organism is guaranteed a uniform state, unless it's unicellular. At best, it can only be a composite of states. However, that might not be good enough, either. Let's take the most extreme example possible - some idiot decides to blend humans and chimpanzees - not through breeding, but through genetic and chimeric techniques.
Now what happens? The cells will very likely fuse extremely well, being far more similar in nature than the pig/human example in the article. Let's say that the result is a "perfect" 50/50 mix. Are they human or not? Would it be possible to tell, without careful DNA analysis?
Ok, now let's say that the ratio is 90% human and that it turns out most people accept the person is human. Fine. Let's also say that, as a result of normal cell mutations (as outlined above) and/or cell replacement the ratio falls over the lifetime to below 50% human. Are they still a person?
Or take the reverse scenario. They start off 90% chimp, and (through cell mutations/replacement) become over 50% human. In other words, can you "become" human after you're born?
It seems to me that the entire problem is very complex and that existing definitions of what an organism is simply aren't good enough to classify organisms that are non-trivially chimeric.
Re:They've been around 3 billion years or so (Score:5, Informative)
The resulting Chimera passes down both the "host" organism plus the mitochondria/chloroplasts with their own unique DNA from the cell proper.
End result: Now these two once foreign cells are essentially the powerhouse of modern life. Chloroplasts are where plants actually convert light energy into chemical energy (stored as sugar) and mitochondria are where plants and animals (and most other assorted organisms as well) then convert sugars into readilly available energy, ATP (Adenosine TriPhosphate.)
Re:They've been around for a while... (Score:2)
Re:They've been around for a while... (Score:2)
"Blending Mice and Men" (Score:5, Funny)
This is how society blends mince and men... (Score:5, Funny)
it's a new age (Score:5, Interesting)
Does a humanzee really have a soul? Should they be granted "human rights"? Can we use them to test drugs or clean out clogged sewer lines? Really quite interesting.
Just another humbling experience for those who think humans are something special apart from the rest of creation.
Re:it's a new age (Score:5, Funny)
More importantly, can they run Linux?
Re:it's a new age (Score:3, Insightful)
Re:it's a new age (Score:4, Insightful)
More likely we'll just revert to the definition of humanity that our ancestors used...
The fact that humanity must be earned (ie, creatures that look human may not necessarily be human)
Hopefully, we'll used enlightened definition of humanity, but the more likely possibility is that we will create slaves.
Re:it's a new age (Score:2)
Hopefully, atleast this will make people realize that animals should be given much the same right as humans. But then, we're having trouble giving rights to most humans to begin with. So I suppose it's asking for too much to hope that we'll grow civilized enough not to kill any animals.
Re:it's a new age (Score:5, Interesting)
"An animal may have rights when it asks for them."
This may be a parahrased quote from a Supreme Court judge. If not, it's one that I'll wager they would agree with.
When your ape signs "please let me vote for president, I care about ecological progress" as interepted by someone without bias, and it can then sign "yes, I swear and understand" in court, it'll be able to win rights in a rather simple court.
But they can't. And so they don't have equal rights to humans.
OTOH, it's entirely civilized to kill humans. It's all about WHEN and WHY that defines civlization, not the actual killing or lack thereof.
Re:it's a new age (Score:2)
Righs come together with responsobility. You can't get one without the other, and I'm afraid animals aren't as good as this as some of the least responsible humans.
Re:it's a new age (Score:2)
Re:it's a new age (Score:3, Funny)
Re:it's a new age (Score:2)
Re:it's a new age (Score:2)
It was modded as such, and then was modded interesting. Chill, I was kidding - do read my other responses to the replies given.
Re:it's a new age (Score:3, Insightful)
Yes, and that inefficiency is reflected in the high price you pay for steak. If you ate foods that required fewer resources, they would be cheaper and you would have more money to spend on other things. The cost of producing whatever you choose to buy instead will be rougly equal to the cost of growing 100lb of grain and feeding it to cattle. The cost may not come from land usage but from other resources whic
Re:it's a new age (Score:2)
Re:it's a new age (Score:3, Funny)
> I hope you are also against experimenting on animals.
>I really think my dog has more self awareness
>than an embryo. So do chimps, lab rats, house flies...
No. Because they are animals.
My ancestors didn't spend millions of years
to get to the top of the food chain so I could
eat kelp.
Re:it's a new age (Score:2)
Oh wait until you hear what I have to say about mature old women.
Re:it's a new age (Score:2)
Or maybe you assumed war. You won't find me defending the current war in Iraq, but I'm sure even you could think of at least one war in history that was worth fighting, even (or especially) if your country didn't start it. Or do 95% advocate immediate surrender if their country is invaded?
I don't know why I'm giving you the benefit of a re
Re:it's a new age (Score:3, Interesting)
Re:it's a new age (Score:3, Insightful)
Rights are not "given", they simply exist. They are a philosophical concept essentially limited to sentient beings. Rights only exist for those that are capable of respecting the rights of others. No animal, as yet, has demonstrated this capability. They do deserve our protection, but they cannot exercise rights.
Re:it's a new age (Score:2)
It sure is. I like steak.
Re:it's a new age (Score:2)
I do think humans are something special, and this one is easy: the difference between humans and animals is the ability to speak.
If this hybrid can speak it's human, if it can't it's not. (And don't give me nonsense about humans who can't speak - that's always either a physical problem, or deafness so they never learned how. Fix those problem and they can speak.)
Even the most retarded perso
Re:it's a new age (Score:3, Insightful)
Can't dolphins speak? Based on your definition, if you correct their physical limitations, they should be able to learn a human tongue.
Of course their language model is different than ours.
Re:it's a new age (Score:5, Insightful)
Whales and dolphins do the same except they use the ocean instead of the atmosphere as a transport media.
In the field I have seen coyotes communication via vocalizations - does that give them soul status?
Re:What's special about human communication (Score:2)
Any parent of an infant would disagree with you greatly.
Re:What's special about human communication (Score:4, Interesting)
No, dogs do not know how to communicate to other dogs at birth, and no, humans are not vocally clean at birth. You simply do not know what you're talking about.
Yes indeed, humans have a communication instinct. Humans raised with only their siblings develop their own language.
Animals do indeed reason. "Convince". Very subjective word there. Reason is seldom built upon right vs wrong, which are abstractions open to individual interpretation anyway. Humans base their reasoning on hunger, play, rest, sex, etc.
Re:it's a new age (Score:5, Informative)
Personhood presently is defined as humanity. If we find or create intelligence that is not human, then we will need a new definition. I would much rather that criteria be based on something substantial, like complex independant reasoning, rather than something as specific and unrelated as speach. Yet that won't happen for some time, since we do not yet have an example of such intelligence, and when we get there, doubtlessly people will cling to the old human definition, and resist change on the basis of emotion or religion.
As a side note, primates and cetacians (dolphins etc) have been shown to have language. In fact, there is a considerable body of evidence supporting the conclusion that dolphins "speak', using their sonar system. Chimps, as I've already mentioned, have shown that they can learn and intelligently use sign language. Defining speech as language, and using your definition of personhood, whould higher mammals such as these qualify? They can speak in a way, and they have demonstrable intellect. If we set a threshold for personhood based on speach, dolphins would qualify, at least. If we used a definiton based on human level intelligence, they would not (but neither would fetuses or the severly mentally disabled, which opens up a major political can of worms, not to mention an ethical debate of huge proportions). There is a valid ethical question here, and genetic engineering is only going to complicate it further. To quote someone whose name I've forgotton "For every complex question there is an answer that is simple, elegant and wrong."
Re:it's a new age (Score:2)
First, what would you make of telepathic species? They don't speak as far as you know. Ants don't speak, but they communicate chemically - this is an example of communication beyond our understanding. Dolphins speak ultrasound; whales speak infrasound; some fish speaks electrically.
Second, apes can be taught human sign language, and they then can talk about simple matters. So do mute/deaf
Re:it's a new age (Score:2)
I'd just like to point out that soul literally means "breather" not "speaker". And that if you really want to get serious about "soul" and what it means you need to take into account that in the hebrew language the term is applied to all living breathing creatures on earth. Of course most people's bibles that are translated into English doesn't use the term soul every time it's written in hebrew, instead it's substituted with "life", "person", "
Not speaking isn't necessarily a "problem"... (Score:2)
Not in the case of non-speaking autistics -- there's no mechanical failure involved, our brains (like those of other species) simply aren't designed to communicate via spoken words any more than non-human species are. We don't consider that a problem, and happily communicate in other ways [autistics.org]; we have no interest in "fixing" the esse [autistics.org]
Re:it's a new age (Score:2)
And yes, I think we can use them to test drugs and clean out sewer lines, since we use humans to do such things now.
Rediculous! (Score:2)
The fact of the matter is, we are indeed something special. Not apart from creation, but special. We, and as far as current research shows, we alone, are the sole holders of the ability to reason: the ability to focus on goals other than those driven by immediate instinct. As Kant once said, we alone are independant moral
See what's gonna happen... (Score:5, Funny)
Wow. A super intelligent mouse. Aren't they afraid that mouse will then get a slow-witted sidekick and try to take over the world? [google.com]
Re:See what's gonna happen... (Score:2)
Re:See what's gonna happen... (Score:3, Funny)
Chimera? (Score:3, Funny)
Pretty soon some arcane naming convention will evolve, and a college-level genetic engineering will be much like organic chemistry with its names oxy-lacto-3-alpha-nano-5-methane.
Culture (Score:5, Interesting)
I'll leave the first and second branch alone and focus on the third. These sorts of experiments probably put the chimeras through a great deal of hardship: we're creating organic systems which are not found in nature, and very probably have deep physiological problems.
My grandparents' ranch bought a critter that was 3/8 buffalo, 1/8 cow, and 1/2 yak. It was a very messed up animal and walked around in a constant state of confusion- I would guess due to conflicting instincts and brain chemistry.
I can only imagine what a mouse with human brain cells (mentioned in the article) would feel like- it'd almost certainly feel unwell, to say the least. Worse yet, how a non-human critter with human brain cells exposed to culture would feel like (and thus being smart enough to 1. know how messed up he is and 2. feel more dimensions of pain).
We may be creating hell on earth for some of these critters. That's not very cool.
RD
Re:Culture (Score:2, Insightful)
"I can only imagine what a mouse with human brain cells..." woah woah. Stop there. Yes, you can imagine that. Have fun with your excellent imagination. But the assertions you make based on your totally random subjective imagining, how can anyone take that se
Re:Culture (Score:2)
and thus being smart enough to 1. know how messed up he is and 2. feel more dimensions of pain.
So the animal will be a teenager (or a 5 - 40 year old geek) from day one?
Stress (Score:2)
Putting a cell from one type of organism into another type of organism is of questionable value. Let's take the testing of drugs as an example. When you blend the cells together, you not only have the two cell types, you have cells which are a mi
Re:Culture (Score:2)
That would indeed be a sad fate: to be
Re:Culture (Score:2)
And this differs from the "reality" that most people on this earth experience how, exactly?
Truely depressing, now that I think about it some.
Re:Culture (Score:2)
When you die, all your memories of "hardship" stored in your neural net melt into the same pile of amino-acid goop. How irrelevant would it be if we all tortured you?
Re:Culture (Score:2)
He's reading Slashdot. He's used to torture.
No problem (Score:2)
Creatures born with such mixed genes are generally neither better nor worse than any other creature with "pure" genes. If they are actually worse they will die. If they are better, they will thrive. Nothing wrong here, that's how the biosphere of this planet operates.
And besides, why should we automatically assume that a being with some "standard" set of genes
Re:No problem (Score:2)
Re:No problem (Score:2)
Re:No problem (Score:2)
We actually already create pleasure slaves - they are called "pets", cats and dogs and other animals that are intentionally bred (poor man's gene engineering) into often something unnatural and unhealthy. It's a large industry, and it doesn't offer any medical benefits to humanity (as opposed to scientifically created chimeras.)
Any moralist is welcome to start with pets right now; it will keep him
Re:No problem (Score:2)
Well, here is a plan then:
I could see this leading to.... (Score:2)
Someone also might want to alert the Fitzgibbon's that they should keep an eye on the Rats [amazon.com] living under their rosebush as they might be up to no good.
Mice with human brains? (Score:2)
From TFA:
Now Weissman says he is thinking about making chimeric mice whose brains are 100 percent human. He proposes keeping tabs on the mice as they develop. If the brains look as if they are taking on a distinctly human architecture -- a development that could hint at a glimmer of humanness -- they could be killed, he said. If they look as if they are organizing themselves in a mouse brain architecture, they could be used for research.
I wonder how humalike a mouse with a 100% human brain would be. I
Re:Mice with human brains? (Score:2)
Neuron count surely matters. A mouse skull won't hold nearly as many neurons as a human one.
It's bad enough (Score:3, Funny)
In the future they'll have to worry about getting drunk and waking up with a real dog. Well, half.
Ruff!
Oh, it'll be "ruff" all right... (Score:2)
Buffalo Wings... (Score:5, Funny)
NOOO! (Score:2, Funny)
Genetic Mosaics (Score:4, Interesting)
This is extremely rare; a case was discovered in 2002 when a woman needed a kidney transplant. Tissue typing revealed her to be a tetragametic individual, having developed from four gametes instead of two. Half her cells were genotypically different from the other half. During development, this woman and her twin fused into one embryo, and appeared to the world after birth to be one person. There are probably more people like this out there. I seem to remember a story where another woman surprisingly failed a maternity test for her own son, and was found to be chimeral.
See here [rcn.com] (or its Google cache [google.com] to avoid slashdotting) for details.
Re:Genetic Mosaics (Score:2)
Scratch that sentence- the failed maternity test was part of the same story about the tetragametic kidney patient. Lucky for her, actually; it meant she could accept kidneys from any of her siblings.
obligatory HHGTTG post (Score:2)
Nature already does the same thing....sorta (Score:2)
I remember thinking a the time what if something like the reverse happens, where one single egg splits in 2 and is fertilized by two different sperms. Would the resulting twins, sharing half their materna
Mutants. (Score:2)
Can we try something less controversial first? (Score:3, Interesting)
I know there are more immediate 'benefits' to immediately going straight to human/animal but there would be plenty to learn by studying animal/animal chimera and we might just avoid making some serious mistakes in the process.
What's the rush all of a sudden? People have suffered from genetic disorders and trauma and disease in the past and will continue to in the future, regardless of how many discoveries we make... why do we need to find all the answers now?
The scientific community needs to learn a little patience and self-control and get their heads out of the pharmaceutical industry's ass and take a breath of fresh air.
The only way human/animal makes sense at this stage in our understanding of this area of science is that the Return on Investment is more immediate.
Is that good enough reason to jump into the deep end before we know how to swim?
Re:Can we try something less controversial first? (Score:3, Interesting)
Apparently when they were doing those experiments they weren't focused on the cellular activities and completely focused on the cellular byproducts... cause I don't remember reading a damn thing about studies being done on whether spider parasites/viruses/bacteria were causing problems for goats as a result of that particular project, or whet
Blade Runner (Score:2)
THACO is so Old School (Score:3, Funny)
I could've used a Chimera earlier tonight (Score:4, Funny)
Oh, you meant something else. Nevermind.
4 asses (Score:2)
Re:4 asses (Score:2)
Here come the Furries..... (Score:2)
Huh? (Score:2, Funny)
Mice and Men? Its been done before. (Score:2, Funny)
You've got to be kidding me. (Score:3, Insightful)
Indeed, I am one of the people who, as the article put it, has a "negative backlash" against giving animals human traits. It's not for religious reasons, either. I'm no Religious Fundamentalist... (EDIT pre-sending: On a quick glance at what I typed, however, perhaps I'm a Humanitarian Fundamentalist. If so, then so be it.)
Rather, a Human is something that, to me, has an innate quality over all other animals: not derived from religion, but rather from the innate quality of being human. Having a capacity to reason, for example. Call me biased towards Humanity, but we are the best thing this planet has produced (indeed, dispite the trouble we cause, which I acknowledge is vast). Giving human parts to animals, at least in large quantities, seems to me to be some kind of basic betrayal of humanity. Whose side are we on, anyways? =)
Small transferences, like the ones mentioned at the very beginning of the article, are mildly disturbing but not outright revolting to me. But as they go on, and talk about potential half-human fetuses in mice (and letting them die as the accidents that they would be), or monkeys with human intelligence disturbs me to the deepest roots of my being. Call it Pro-Humanity zeal if you wish, but Humans > Monkeys. I mean, look at us, and what we've done! We are all here right now, typing in a complex common language over wires that harnass the fundamental powers of energy, and into a complex system of "code" which are products of our thought and our will to create something that serves us beyond our desire for mere survival.
Indeed, humans have done some horrible things as well, and continue to do them. But as it stands, humanity is one thing I will hold an allegiance to. I don't believe in having zeal for a government (which tends to be one of the more faulty institutions of our humanity), or for most beliefs (the zeal for which some people wrongly hold to them cause a great deal of the horrible things I spoke of), or for most organized groups in general. But humanity as a whole is something that, to me, is worth pledging allegiance to. If another animal species can come to our point on their own, then so be it: they would be our peers. But to make some human/animal cross breed feels to me to be the closest I have ever come to calling something treasonous. Usually I find the word absurd, as its usual political usage comes with a heavy bias and hides a greater truth. But for some reason, it feels... appropriate here.
So in summation, Hum4n5 >> 4n1m475, Hum4n1ty r0xx0rz j00, and other such nonsense.
Re:I for one... (Score:5, Funny)
Re:Alchemists and Lives (Score:2)
Does or can that alchemy expand through experimental means? If not, then it is not necessarily a good model. If so, then is the inability to restore human life an upper limit of the science? If so, then surely it is not a good model again. If not, then is it fesable that such a mark be reached and surpassed at some point in the future?
Tha
Arbitrary bullshit (Score:2, Insightful)
In other words, it's meaningless restrictive nonsense.
I don't want "Ethicists" with an bachelor's in liberal arts deciding what people with Ph.D.s in Biology do in their research. It's asinine in the extreme. They are unqualified to decide.
Science needs to progress free of undue influence from people who haven't the slightest clue of how the field functions. It's the only rational thing
Ironic (Score:2)
In a post with the subject "Arbitrary bullshit", you say you don't want BA's telling PhD's what to do, that "It's asinine in the extreme. They are unqualified to decide." And then the irony; you say:
Take your own advice.
Your post also reveals that you hold a common misconception of ethics. Ethics are what people turn to when the law and morality fail. They are rules for behavior that don't label things "right" and "wrong".
Medical doctors have to decide which patient to t
Re:Oh, the pain! (Score:2)
Being an atheist what forms the ground truth of your "ethics"?
Many things could... (Score:3, Interesting)
I myself, though mildly religious, am a believer in Kantian ethics: and thus, I base my judgments of morality not on Religion (which has morals but no rational grounding for them), but rather on Philosophy (which sometimes has morals but always has a more or less reasonable rational explanation for wh
Re:Many things could... (Score:3, Interesting)
Oh, I think they have plenty of rational grounding for them, but there simply wasn't an appealling reason for the authors to include a balanced discussion of the pros and cons for their societal laws 1500 or 2000 years ago. I also doubt very much that the authors were planning ahead for the changes in society that might happen over the next 2000 years.
If we had a time machine and asked these guys why sex
Re:Oh, the pain! (Score:3, Insightful)
Would this not mean that your ethics are based on the principle of increasing the probability of replicating the set of genes that constitute you.
Re:Who needs China when we can make Chimeras? (Score:2)
The pigs for transplants are raised in sterile conditions, so the only viruses to worry about are those transmitted longitudally--i.e. the ones that copy themselves into DNA and are inherited from the parents. But people have been li
Re:Who needs China when we can make Chimeras? (Score:2)
any thoughts?
You know... (Score:2)
Re:Morals? Wha? (Score:2)
Re:Welcome to the 21st century! (Score:3, Funny)
Re:The thing is... (Score:3, Interesting)