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Science

Researchers Discover the First 'Heart Attack' Gene 28

jimi1283 writes "A group of researchers recently conducted a study on 100 members of a family that had a high percentage of heart attack and other coronary disease. The study lead to the discovery of the gene responsible."
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Researchers Discover the First 'Heart Attack' Gene

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  • Never a single gene (Score:4, Informative)

    by maddu ( 522722 ) on Friday November 28, 2003 @12:20PM (#7582729)
    There is never *one* gene that causes a particular problem. Multiple genes are responsible almost always. Something as common as a heart attack will have multiple causes.
    • by Smidge204 ( 605297 ) on Friday November 28, 2003 @01:57PM (#7583329) Journal
      From the article you probably didn't read:

      The gene makes a protein that regulates some other genes and Topol said those will now be analyzed to see if they can be linked generally to heart disease.

      So no, it's probably not just that gene, but in general it seems the problem starts from here and cascades down.

      I'm not a biologist, but I think until they've mapped out every single gene and know exactly what it does, it might be wise to refain from words like "never" and "always". :)
      =Smidge=
      • I'm no bio major, but from what I understanad:

        no, they have basically mapped out the human genome, but they have no clue what most of it is.
        ATGC...uh yea...very meaningful.

        The way they find genes is that they take a specimen that exhibits a specefic characteristic.
        say, pigmentation of the skin.
        then they find a specimen that doesn't show tht characteristic: an albino specimen.

        They take the albino specimen, map out its gene, take the "normal" specimen and map out its gene.
        then its a matter of "hunting" dow
    • Hogwash. Why do people post opinions (and get modded up) when they don't know what they are talking about? Oh, right, slashdot. forgot for a second. I am a biologist (biochemist actually), and I can assure you there are numerous examples of diseases caused one gene: sickle cell, some forms of retinitis pigmentosa (night blindness), cystic fibrosis, etc. etc.
    • Hogwash! There are MANY diseases caused by mutations in just one gene.

      Examples include sickle cell, cystic fibrosis, phenylketonuria (PKU), some forms of retinitis pigmentosa (night blindness), etc. etc.
      • well...read my post. I said "almost always". The diseases you have mentioned are rare. And can be traced back to a single gene. On the other hand, heart attack is so common.
        • I did read your post, after I read your subject header which states "Never a single gene"

          Perhaps you meant "almost always". But if you meant that, then should have said that in your subject line.

          Thus, I stand by MY response, i.e. "Never a single gene..WRONG" is is factually correct.

          Cheerios
  • I was just about to head out for some lunch...maybe i will grab that cheeseburger i was thinking of...

    Wonder how many people will use this finding as a reason not to work out / eat right.
  • what?! 100 members? Did they do this research on the Clampetts or something!? ;-)

    -psy
  • by G4from128k ( 686170 ) on Friday November 28, 2003 @01:11PM (#7583085)
    Ethics and public policty really can't handle this type of knowledge on who can get what disease after exposure to common environmental factors or habits. Current health policy standards and EPA guidelines assume that "all people are created equal." Thus, the EPA sets carcinogen levels to create a less than one-in-a-million chance of getting cancer. But what happens now that we know that we are not all created equal -- instead of everyone having a one-in-a-million chance, we have 999,999 people with no chance of cancer and 1 genetically identifiable person per million with a 100% chance of cancer.

    The existence of distinct genetic susceptabilities to high-fat foods, smoking, carcinogens, medications, etc. makes it hard to create uniform regulations for food, medicine, and occupational conditions.
    • Ethics and public policty really can't handle this type of knowledge on who can get what disease after exposure to common environmental factors or habits.

      If my genetic test shows that the cyanide in almonds can cause me lung damage, and somebody else's test shows that the aflatoxin in peanuts will cause her liver damage, then I'll eat peanuts and she'll eat almonds and everyone will have a healthy, nut-enhanced existence.

      The argument for ignorance says that we should ban genetic testing, criminalize pean

      • Well, i think part of that problem is that a peanut allergy can develop at any age, and it's an allergy that can kill. This isn't like banning cigarettes- it's like banning dynamite. Peanut allergies, especially for kids, can be a sudden deadly discovery, not a nuisance. And the amount required for a kid with a severe peanut allergy to die is nowhere near the pick-up-a-peanut-and-eat-it level. It's trace amounts, like you can get from sitting at a table with kids eating peanut butter sandwiches.

        Since it's

  • by Scrameustache ( 459504 ) on Friday November 28, 2003 @02:32PM (#7583504) Homepage Journal
    It seems that it is a gene also responsible for an organ called a "heart" wich has some function within the circulatory system.

    Scientists will now attemp to remove that gene and see how things develop...
  • How long before... (Score:3, Interesting)

    by gillbates ( 106458 ) on Friday November 28, 2003 @04:05PM (#7583965) Homepage Journal

    DNA testing is required to get a job, health insurance, etc....

    Gattaca isn't far away...

  • by XenonChloride ( 718512 ) on Saturday November 29, 2003 @04:11AM (#7586432)
    Whoever isn't really satisfied with the information given in the CNN article might want to have a look at the Heart News [clevelandclinic.org], where Eric Topol points out:
    People with this exact MEF2A mutation have essentially a 100-percent chance of having a heart attack or developing coronary artery disease [...] For people without a genetic predisposition, they must make it their responsibility to take care of themselves to prevent heart disease from developing.
    So for all the obese guys out there:
    Think about some other famous last words than It is all genetic [...]
  • To claim that there is a gene or a number of genes that leads to a propensity to have a heart attack seems to be putting the cart before the horse. While opinions differ, there seems to be no clearcut answer the the question "What is a gene?" Now we can talk about cistones and amino acid sequences, but such a question runs deeper than that. Richard Dawkins, author of the "Selfish Gene Theory" claims that genes are active replicators or that genes replicate for the purpose of increasing its population and
  • I suggest this be named the 'Elizabeth' gene. [museum.tv]

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