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Science

Humans Make Ozone 50

MondoMor writes "Spotted this article at the Scripps Research Institute. Apparently humans have the ability to manufacture ozone, and do so as an immune response. Suppose we took a bunch of lawyers to the south pole, right under the ozone hole..."
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Humans Make Ozone

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  • Lawyers? (Score:5, Funny)

    by KILNA ( 536949 ) on Friday February 28, 2003 @05:14PM (#5409814) Journal
    I thought you said humans produce ozone?
  • by topologist ( 644470 ) on Friday February 28, 2003 @05:35PM (#5409966)
    Oh,I have long known this, although I was thinking of the *other* way of producing ozone. Walk across a thick carpet or rub against an upholstered chair and accumulate some static. Then head to the nearest metal doorknob and put your finger near the knob..you'll probably see an arc jump from an extremity like a finger to the doorknob ("point discharge"). Electric discharges in oxygen can form ozone (O3), and you can actually smell it in some machine rooms, and after a burts of lightning. Of course, the static discharge is not exactly pleasant, but we all have to make sacrifices in the cause of science :-) Unless of course you're one of those people who liked touching battery leads or an electrode hooked up to a lemon to your tongue..
  • and? (Score:2, Funny)

    by Anonymous Coward

    Suppose we took a bunch of lawyers to the south pole, right under the ozone hole...

    Sure, and cut them all down with machine guns and bury them in a mass unmarked grave. I've had that dream too. But how does that help the ozone layer? And why the South Pole?

  • by magickalhack ( 648733 ) on Friday February 28, 2003 @05:46PM (#5410038) Homepage
    Ozone is ozone, but we only like it when it's it the upper atmosphere where it can block UV radiation. Down here it is a poison [drgreene.com].
    • by Bowling Moses ( 591924 ) on Friday February 28, 2003 @06:43PM (#5410440) Journal
      As the article states, ozone is produced by neutrophils as a part of an immune response. Not too surprising; redox chemistry is critically important and we've evolved ways of protecting ourselves from harmful oxidation. For example the enzyme catalase converts hydrogen peroxide into water and hydrogen, while superoxide dismutase is a free radical scavenger. I wouldn't be too surprised if there's a specialized anti-ozone protein as well. Anyway, neutrophils engulf bacteria (and other things) and the engulfed matter ends up in an intracellular compartment called a phagosome. The neutrophil pumps in various nasty compounds--I imagine ozone may be one of them--to kill whatever it engulfed. I'd imagine that neutrophils have higher than normal expression levels for catalase and other protective enzymes to protect itself...from itself.
      • by forkboy ( 8644 ) on Friday February 28, 2003 @10:47PM (#5411369) Homepage
        For example the enzyme catalase converts hydrogen peroxide into water and hydrogen, while superoxide dismutase is a free radical scavenger.

        Interesting....those are the two main results of exposure to ionizing radiation, (aside from damage to cellular structures directly) the cleavage of water molecules in cells to form hydrogen peroxide (toxic to cells) and formation free radicals (causes chemical changes in DNA molecules). Why aren't these two enzymes used in treatment of radiation exposure? Are they difficult to synthesize or unstable or something?

        • Why aren't these two enzymes used in treatment of radiation exposure? Are they difficult to synthesize or unstable or something?

          They can be made easily enough, its delevering them to the right place thats the problem.

          Not only would you have to get these massive proteins through the Plasma Membrane [maricopa.edu] but also into the nucleus [maricopa.edu] where the DNA you want to protect is stored. This is hard enough to do with normal drugs which are typically about 500-1000 times smaller than proteins....

        • Why aren't these two enzymes used in treatment of radiation exposure? Are they difficult to synthesize or unstable or something?

          As another poster has noted [slashdot.org], the enzymes described are too large to be delivered through the cell and nuclear membranes to the nucleus in order to protect DNA.

          Also, the damage done by ionizing radiation is done quite quickly. The enzymes mentioned might have some protective effect if administered prophylactically--before radiation exposure--and if delivery were not an issue. (There is some experimental work being done that suggests gene therapy could be use to encourage cells to produce their own radioprotective agents [cjp.com] This neatly sidesteps delivery problems, since the enzymes are produced in situ.)

          Within a few seconds after the end of the exposure, the damage to DNA has been done, and the particularly nasty radicals and peroxides have pretty much been consumed. (The reason why these species are damaging is that they are so reactive--thus they don't last long with lots of tasty biomolecules around.) We would be closing the barn door after the horse is already gone.

      • Wow. I'm sure that paragraph makes sense, but it could just as well have been in Norwegian for all it meant to me. If you say that stuff out loud, does your tongue hurt?
      • Not trying to be an ass, but catalase breaks 2H202 into 2H20 and 1O2 not 2H202 into 2H202 and 1H2.
    • by superyooser ( 100462 ) on Saturday March 01, 2003 @03:10AM (#5412163) Homepage Journal
      Ozone is poisonous at very high levels, but so is oxygen (relative to normal levels). Ozone has a strangely fresh, sweet odor. Sometimes you can smell it outside after a lightning storm. The odor is easily detectable at safe levels and is not necessarily a sign of danger.

      At .05 ppm (parts per million) or less, ozone is not only safe, but healthy. I have two air purifier/ionizers [surroundair.com] in my bedroom (more than recommended for its size), which produce ozone. It's not like I'm gassing myself. Read the FAQ for all the technical details.

      From your linked page: "There's this bike path near my house, but when I walk or run on it on ozone alert days I spend the next few hours coughing." -- Melissa, age 68

      There must be a very high concentration of ozone at that particular location. My allergies hardly bother me at all since I put these ozone-producing devices in my house (one beside my bed pillow!), which run 24 hours a day. After taking allergy shots every month for many years, I don't need the shots anymore. The ozone negative ions remove contaminants from the air.

      See this [surroundair.com].

      In studies conducted at the Academy of Medical Sciences in Russia, Dr. Gubernskii and Dr. Dmitriev found that 0.005 ppm (parts per million) to 0.02 ppm of ozone added to normal indoor air (0 ppm) increased animals' resistance to the cold, to infection, to toxic substances, and to oxygen deprivation. A general increase in the immune "biological potential" and the vital capacity of the lungs was reported.


      Dr. Gubernskii and Dr. Dmitriev also performed tests using less than .01 ppm of ozone in an air-conditioned office building, which revealed that "the levels of oxygen in the blood increase relatively quickly and remain at a high level for the duration of the experiment." They also stated that: "Atmospheric ozone has a positive effect on animals and people. It is important to note its positive effect on the breathing system, blood composition, arterial pressure, immune system, general feeling of well-being, and mental and physical work capability. The ozone-ion complex is a necessary component of fresh air that gives it a curative effect."

      This same study, featured in the Russian journal Priroda, also reports a decrease in complaints of stuffiness (3.8 times fewer complaints).
      And there's a lot more information on that site. Based on personal experience with their product, I'm inclined to believe in their research and conclusions.
  • and more... (Score:3, Funny)

    by Polo ( 30659 ) on Friday February 28, 2003 @05:56PM (#5410123) Homepage

    Methane too ;)
  • How much.... (Score:1, Insightful)

    by ewhenn ( 647989 )
    How much Ozone does a person make while driving around in their SUV?
  • by juushin ( 632556 ) on Friday February 28, 2003 @06:08PM (#5410216)
    That immune cells have been found to produce singlet oxygen is much more interesting, I think, than the finding that bodies produce ozone.

    Dude, if you thought that ozone is bad news, singlet oxygen is highly toxic to just about everything biological.

  • Cancer? (Score:5, Interesting)

    by planux ( 598669 ) on Friday February 28, 2003 @07:07PM (#5410551) Journal
    If I'm not mistaken, oxidants cause mutations in the DNA of your cells -- and if that mutation happens to occur in some vital bit of the DNA, you get cancer. Cancer cells are, fundamently, normal cells that have gone awry and reproduce extremely quickly. That's why chemotherapy is used to treat cancer -- chemotherapy targets fast-reproducing cells (also why it makes your hair fall out -- hair cells are another fast reproducing cell type). In any case, if your body produces oxidants to fight germs, couldn't those same oxidants be causing, as a side affect, mutations in your DNA? Maybe the dramatic rise in cancer rates over the past x*10^2 years isn't due entirely to our longer life spans -- maybe it's also, in part, due to the fact that we live much closer together and regularly infect and are infected by our family members/cow-workers/fellow K-mart shoppers. The common cold a cause of cancer? Maybe not so far fetched. And maybe it's the body's oxidant-loaded response to things like cigarettes that causes cancer -- not the cigarette chemicals themselves (though I am very poorly acquainted with cigarette research). Also, what impact would those anti-oxidant drinks/pills/suppositories that are all the fad these days have on your body's ability to fight off diseases?
    • Re:Cancer? (Score:2, Informative)

      by Anonymous Coward
      Alright..first of all, not all oxidants are bad for you. A lot of them are produced -by- your body for a number of different purposes. Secondly, those anti-oxidant suppliments can be far more dangerous than just accepting the normal amount that your body produces..too much of them are known to cause permanent damage if taken excessively.
  • This isn't listed on the main page. We all must be using some sort of headline grabber.
  • hmm.. (Score:3, Interesting)

    by C21 ( 643569 ) on Friday February 28, 2003 @08:30PM (#5410848)
    this reminds me of the terraforming discussion we had a few days ago. Accelerated technology on ozone production is not only good for our planet, but for others in the future. Wasn't there a release in Nature or some such magazine that stated that the hole in the ozone wall was repairing itself, though? Kinda harsh if we get up these billion dollar ozone making plants and they're obsoleted by good old mother earth...
  • Well, this is quite interesting. We could create biomass in the atmosphere, and let it generate Ozone up there, using biological technology. I bet it would work!
    • it would be more cost effective to do it on the ground and let the ozone make it's way up to the atmosphere.
      • Re:Ozone (Score:1, Informative)

        by Anonymous Coward
        mm except they will get oxidized on the way up by things like sulfur etc and other gases in the atmosphere, 03 exactly the state Oxygen *wants* to be in, and it would be happy to bond with nearly any other element on the way "up" to the ozone. so thats a no go.
  • Put a bunch of laweyrs there, and they will get a court order of every body else out of planet earth

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