Several large-scale, human-driven changes to the planet -- including climate change, the loss of biodiversity and the spread of invasive species -- are making infectious diseases more dangerous to people, animals and plants, according to a new study. From a report: Scientists have documented these effects before in more targeted studies that have focused on specific diseases and ecosystems. For instance, they have found that a warming climate may be helping malaria expand in Africa and that a decline in wildlife diversity may be boosting Lyme disease cases in North America. But the new research, a meta-analysis of nearly 1,000 previous studies, suggests that these patterns are relatively consistent around the globe and across the tree of life.

"It's a big step forward in the science," said Colin Carlson, a biologist at Georgetown University, who was not an author of the new analysis. "This paper is one of the strongest pieces of evidence that I think has been published that shows how important it is health systems start getting ready to exist in a world with climate change, with biodiversity loss." In what is likely to come as a more surprising finding, the researchers also found that urbanization decreased the risk of infectious disease. The new analysis, which was published in Nature on Wednesday, focused on five "global change drivers" that are altering ecosystems across the planet: biodiversity change, climate change, chemical pollution, the introduction of nonnative species and habitat loss or change.

AstraZeneca said on Tuesday it had initiated the worldwide withdrawal of its COVID-19 vaccine due to a "surplus of available updated vaccines" since the pandemic. From a report: The company also said it would proceed to withdraw the vaccine Vaxzevria's marketing authorizations within Europe. "As multiple, variant COVID-19 vaccines have since been developed there is a surplus of available updated vaccines," the company said, adding that this had led to a decline in demand for Vaxzevria, which is no longer being manufactured or supplied. According to media reports, the Anglo-Swedish drugmaker has previously admitted in court documents that the vaccine causes side-effects such as blood clots and low blood platelet counts.

Pam Belluck reports via the New York Times: Scientists are proposing a new way of understanding the genetics of Alzheimer's that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease. Currently, the vast majority of Alzheimer's cases do not have a clearly identified cause. The new designation, proposed in a study published Monday, could broaden the scope of efforts to develop treatments, including gene therapy, and affect the design of clinical trials. It could also mean that hundreds of thousands of people in the United States alone could, if they chose, receive a diagnosis of Alzheimer's before developing any symptoms of cognitive decline, although there currently are no treatments for people at that stage. The new classification would make this type of Alzheimer's one of the most common genetic disorders in the world, medical experts said.

"This reconceptualization that we're proposing affects not a small minority of people," said Dr. Juan Fortea, an author of the study and the director of the Sant Pau Memory Unit in Barcelona, Spain. "Sometimes we say that we don't know the cause of Alzheimer's disease," but, he said, this would mean that about 15 to 20 percent of cases "can be tracked back to a cause, and the cause is in the genes." The idea involves a gene variant called APOE4. Scientists have long known that inheriting one copy of the variant increases the risk of developing Alzheimer's, and that people with two copies, inherited from each parent, have vastly increased risk.

The new study, published in the journal Nature Medicine, analyzed data from over 500 people with two copies of APOE4, a significantly larger pool than in previous studies. The researchers found that almost all of those patients developed the biological pathology of Alzheimer's, and the authors say that two copies of APOE4 should now be considered a cause of Alzheimer's -- not simply a risk factor. The patients also developed Alzheimer's pathology relatively young, the study found. By age 55, over 95 percent had biological markers associated with the disease. By 65, almost all had abnormal levels of a protein called amyloid that forms plaques in the brain, a hallmark of Alzheimer's. And many started developing symptoms of cognitive decline at age 65, younger than most people without the APOE4 variant.

For the second time, the disgraced former CEO of Theranos has had her federal prison sentence shortened. In July, it was reduced by two years. Now, 40-year-old Holmes is scheduled for release on August 16, 2032 instead of December 29, 2032 -- a reduction of more than four months. The Guardian reports: People incarcerated in the U.S. can have their sentences shortened for good conduct and for completing rehabilitation programs, such as a substance abuse program. The latest reduction of Holmes's sentence still meets federal sentencing guidelines. Those guidelines mandate that people convicted of federal offenses must serve at least 85% of their sentence, regardless of reductions for good behavior.

In 2022, Holmes was sentenced to 11 years and three months in prison after being convicted on four counts of defrauding investors. She was also ordered to pay $452m in restitution to those she defrauded, but a judge delayed those payments due to Holmes's "limited financial resources." Holmes's lawyers have already begun attempts to get her conviction overturned. Oral arguments for her appeal are set to begin on June 11 in a federal appeals court in San Francisco, California, NBC News reported.

"Out of an abundance of caution," Boeing says its historic Starliner launch has been postponed, citing an issue with the oxygen relief valve on the Atlas V rocket's upper stage. It was expected to launch tonight at 10:34 p.m. ET. TechCrunch reports: There are backup launch opportunities on May 7, 10 and 11. After years of delays and over $1 billion in cost overruns, the mission is set to be Boeing's first attempt to transport astronauts to the International Space Station. Once the issue is resolved with the upper stage, the United Launch Alliance Atlas V will carry the CST-100 Starliner capsule to orbit along with the two onboard astronauts -- Butch Wilmore and Sunny Williams -- from Florida's Cape Canaveral at 10:34 PM local time Monday evening. The mission also marks the first time ULA's Atlas will carry crew. The rocket boasts a success rate of 100% across 99 missions. (ULA is a joint venture of Boeing and Lockheed Martin.)

The astronauts would now dock at the station at the earliest on Thursday, where they would remain for at least eight days. The two astronauts will return to Earth in the capsule no earlier than May 16. If all goes to plan, Boeing will be able to finally certify its Starliner for human transportation and begin fulfilling the terms of its $4.2 billion NASA astronaut taxi contract. That contract, under the agency's Commercial Crew Program, was awarded in 2014. Elon Musk's SpaceX was also granted a contract under that program, for its Crew Dragon capsule, and has been transporting astronauts to and from the ISS since 2020.

Science Alert reports that a team of researchers found "that changes in glucose metabolism could help cancer grow by temporarily disabling a gene that protects us from tumors called BRCA2." The team first examined people who inherited one faulty copy of BRCA2. They found that cells from these people were more sensitive to methylglyoxal (MGO), which is produced when cells break down glucose for energy in the process of glycolysis. Glycolysis generates over 90 percent of the MGO in cells, which a pair of enzymes typically keep to minimal levels. In the event they can't keep up, high MGO levels can lead to the formation of harmful compounds that damage DNA and proteins. In conditions like diabetes, where MGO levels are elevated due to high blood sugar, these harmful compounds contribute to disease complications.

The researchers discovered that MGO can temporarily disable the tumor-suppressing functions of the BRCA2 protein, resulting in mutations linked to cancer development...

As the BRCA2 allele isn't permanently inactivated, functional forms of the protein it produces can later return to normal levels. But cells repeatedly exposed to MGO may continue to accumulate cancer-causing mutations whenever existing BRCA2 protein production fails. Overall, this suggests that changes in glucose metabolism can disrupt BRCA2 function via MGO, contributing to the development and progression of cancer...

This new information may lead to strategies for cancer prevention or early detection. "Methylglyoxal can be easily detected by a blood test for HbA1C, which could potentially be used as a marker," Venkitaraman says. "Furthermore, high methylglyoxal levels can usually be controlled with medicines and a good diet, creating avenues for proactive measures against the initiation of cancer."
Their research has been published in Cell.

An anonymous reader shared this report from the Guardian: Newly deciphered passages from a papyrus scroll that was buried beneath layers of volcanic ash after the AD79 eruption of Mount Vesuvius may have shed light on the final hours of Plato, a key figure in the history of western philosophy. In a groundbreaking discovery, the ancient scroll was found to contain a previously unknown narrative detailing how the Greek philosopher spent his last evening, describing how he listened to music played on a flute by a Thracian slave girl. Despite battling a fever and being on the brink of death, Plato — who was known as a disciple of Socrates and a mentor to Aristotle, and who died in Athens around 348BC — retained enough lucidity to critique the musician for her lack of rhythm, the account suggests....

In a presentation of the research findings at the National Library of Naples, Prof Graziano Ranocchia, of the University of Pisa, who spearheaded the team responsible for unearthing the carbonised scroll, described the discovery as an "extraordinary outcome that enriches our understanding of ancient history". He said: "Thanks to the most advanced imaging diagnostic techniques, we are finally able to read and decipher new sections of texts that previously seemed inaccessible... For the first time, we have been able to read sequences of hidden letters from the papyri that were enfolded within multiple layers, stuck to each other over the centuries, through an unrolling process using a mechanical technique that disrupted whole fragments of text."

"A leap in our ability to see the chemistry of matter in three-dimensions at the nanoscale was achieved, allowing scientists to understand how nanomaterials are chemically arranged," writes Slashdot reader Hovden: Traditionally, seeing matter at the smallest sizes requires too many high-energy electrons for 3D chemical imaging. The high beam exposure destroys the specimen before an experiment is completed. Even larger doses are required to achieve high resolution.

Thus, chemical mapping in 3D has been unachievable except at lower resolution with the most radiation-hard materials.

High-resolution 3D chemical imaging is now achievable near or below one-nanometer resolution. A team from Dow Chemical and the University of Michigan used a newly introduced method, called multi-modal data fusion, high-resolution chemical tomography, that provides 99% less dose by linking information encoded within both elastic and inelastic scattered signals. The researchers showed sub-nanometer 3D resolution of chemistry is measurable for a broad class of geometrically and compositionally complex materials.
"Here are the pretty pictures," adds long-time Slashdot reader thoper.

Phys.org also has this quote from Robert Hovden, an associate professor of materials science and engineering at the University of Michigan and corresponding author on the study published in Nature Communications. "Seeing invisible worlds, far smaller than the wavelengths of light, is absolutely critical to understanding the matter we are engineering at the nanoscale, not just in 2D but in 3D as well."

An anonymous reader shared this report from the New York Times: American officials are trying to increase international pressure on Russia not to deploy an antisatellite nuclear weapon in space, and have obtained information that undermines Moscow's explanation that the device it is developing is for peaceful scientific purposes, a senior State Department official said on Friday...

On Friday, Mallory Stewart, the assistant secretary of state for arms control, said that while the United States had been aware of Russia's pursuit of such a device for years, "only recently have we been able to make a more precise assessment of their progress." Ms. Stewart, speaking at the nonpartisan Center for Strategic and International Studies in Washington, said the orbit the Russian satellite would occupy is in a high-radiation region not used by other satellites, information that undercuts Russia's defense that it is not developing a weapon.

An anonymous reader shared this report from the Washington Post: The heat shield of the Orion spacecraft intended one day to carry astronauts to the moon under NASA's Artemis program suffered unexpected damage in more than 100 places as the spacecraft returned to Earth during an uncrewed test flight in 2022, according to a watchdog report released late Wednesday.

While the capsule withstood the fiery tumult of reentry, when temperatures reached 5,000 degrees Fahrenheit as it plunged through the atmosphere at nearly 25,000 mph, the damage the heat shield suffered was far greater than NASA engineers had expected and more severe than NASA had revealed previously. Photos of the heat shield in the report showed gouges that look like small potholes. "Should the same issue occur on future Artemis missions, it could lead to the loss of the vehicle or crew," the report, by NASA's inspector general, concluded... The IG report provides the most detailed description of the issue to date. It also highlighted other problems with the spacecraft that could create significant challenges for the space agency as it seeks to return humans to the lunar surface for the first time in more than 50 years.

Portions of the heat shield "wore away differently than NASA engineers predicted, cracking and breaking off the spacecraft in fragments that created a trail of debris rather than melting away as designed," according to the report. That, in turn, "could have caused enough structural damage to cause one of Orion's parachutes to fail...." In addition to the heat shield erosion on Orion, which is manufactured by Lockheed Martin, the IG said several bolts on the crew module "experienced an exposed gap that allowed for increased heating to the bolt interior and greater than expected melting and erosion."
Earlier this year, NASA announced the next flight for its moon program — sending a crew of four around the moon — would be delayed, according to the article. The moon-orbiting mission would now occur "no earlier than September 2025, largely because officials wanted to study the heat shield issue further and understand why it eroded as it did."

The article adds that this new report "casts doubt on both NASA's rosy original assessment of the test flight" — as well as the likelihood that a lunar landing will occur by late 2026.

The world's highest astronomical site is officially open for business after being in the works for 26 years. Space.com reports: The Japanese University of Tokyo Atacama Observatory, or TAO, which was first conceptualized 26 years ago to study the evolution of galaxies and exoplanets, is perched on top of a tall mountain in the Chilean Andes at 5,640 meters (18,500 feet) above sea level. The facility's altitude surpasses even the Atacama Large Millimeter Array, which is at an elevation of 5,050 meters (16,570 feet).

TAO is located on the summit of Atacama's Cerro Chajnantor mountain, whose name means "place of departure" in the now-extinct Kunza language of the indigenous Likan Antai community. The region's high altitude, sparse atmosphere and perennially arid climate is deadly to humans, but makes an excellent spot for infrared telescopes like TAO as their observational accuracies rely on low moisture levels, which render Earth's atmosphere transparent in infrared wavelengths.

TAO's 6.5-meter telescope consists of two science instruments designed to observe the universe in infrared, which is electromagnetic radiation with a wavelength longer than visible light but shorter than microwaves. One of the instruments, named SWIMS, will image galaxies from the very early universe to understand how they coalesced out of pristine dust and gas, a process whose specifics remain murky despite decades of research. The second, named MIMIZUKU, will aid the overarching science goal by studying primordial disks of dust within which stars and galaxies are known to form, according to the mission plan. Constructing the telescope on the summit of Mt. Chajnantor "was an incredible challenge, not just technically, but politically too," Yuzuru Yoshii, a professor at the University of Tokyo in Japan who spearheaded TAO since 1998, said in a statement. "I have liaised with Indigenous peoples to ensure their rights and views are considered, the Chilean government to secure permission, local universities for technical collaboration, and even the Chilean Health Ministry to make sure people can work at that altitude in a safe manner."

"Thanks to all involved, research I've only ever dreamed about can soon become a reality, and I couldn't be happier," he added.

China launched an uncrewed lunar mission Friday that aims to bring back samples from the far side of the moon for the first time, in a potentially major step forward for the country's ambitious space program. From a report: The Chang'e-6 probe -- China's most complex robotic lunar mission to date -- blasted off on a Long March-5 rocket from the Wenchang Space Launch Center in south China's Hainan island, where space fans had gathered to watch the historic moment. The country's National Space Administration said the launch was a success. The launch marks the start of a mission that aims to be a key milestone in China's push to become a dominant space power with plans to land astronauts on the moon by 2030 and build a research base on its south pole.

It comes as a growing number of countries, including the United States, eye the strategic and scientific benefits of expanded lunar exploration in an increasingly competitive field. China's planned 53-day mission would see the Chang'e-6 lander touch down in a gaping crater on the moon's far side, which never faces Earth. China became the first and only country to land on the moon's far side during its 2019 Chang'e-4 mission. Any far-side samples retrieved by the Chang'e-6 lander could help scientists peer back into the evolution of the moon and the solar system itself -- and provide important data to advance China's lunar ambitions.

Aria Alamalhodaei reports via TechCrunch: Hubble Network has become the first company in history to establish a Bluetooth connection directly to a satellite -- a critical technology validation for the company, potentially opening the door to connecting millions more devices anywhere in the world. The Seattle-based startup launched its first two satellites to orbit on SpaceX's Transporter-10 ride-share mission in March; since that time, the company confirmed that it has received signals from the onboard 3.5mm Bluetooth chips from over 600 kilometers away.

The sky is truly the limit for space-enabled Bluetooth devices: the startup says its technology can be used in markets including logistics, cattle tracking, smart collars for pets, GPS watches for kids, car inventory, construction sites, and soil temperature monitoring. Haro said the low-hanging fruit is those industries that are desperate for network coverage even once per day, like remote asset monitoring for the oil and gas industry. As the constellation scales, Hubble will turn its attention to sectors that may need more frequent updates, like soil monitoring, to continuous coverage use cases like fall monitoring for the elderly. Once its up and running, a customer would simply need to integrate their devices' chipsets with a piece of firmware to enable connection to Hubble's network.

In a first for "digital health technology," the Apple Watch's atrial fibrillation (AFib) history feature has been approved by the FDA to join the FDA's Medical Device Development Tools (MDDT) program. This means the wearable is now usable in clinical studies. The Verge reports: The FDA announcement describes using it as a noninvasive way to collect the data both before and after treatment: "Designed to be used as a biomarker test to help evaluate estimates of AFib burden as a secondary effectiveness endpoint within clinical studies intended to evaluate the safety and effectiveness of cardiac ablation devices to treat."

When given the choice, pet parrots prefer to video-call each other instead of watch pre-recorded videos of other birds. Those are the findings from a new paper (PDF) set to appear next week at a conference on Human Factors in Computing Systems in Hawaii. Phys.Org reports: The study, led by animal-computer interaction specialists at the University of Glasgow, gave tablet devices to nine parrots and their owners to explore the potential of the video chats to expand the birds' social lives. Their results suggest that the clever birds, who often suffer from loneliness in captivity, may be able to tell the difference between live and pre-recorded content on digital devices, and strongly prefer interacting with other birds in real time.

Over the course of the six-month study, the parrots chose to initiate calls to other birds significantly more often than they opted to watch pre-recorded footage. They also seemed more engaged in the live chats, spending much longer on calls with other birds than they did watching videos from a library of options. The findings could help steer the future course of the emerging "animal internet," which uses digital technology to empower animals to interact with humans and each other in new ways.