An anonymous reader shares a report: In 2013, scientists unveiled the first lab-grown burger at a cost of $330,000. By 2023, the FDA approved cultivated chicken for sale. The price had dropped to around $10-$30 per pound, and over $3 billion in investor money had poured into more than 175 companies developing meat grown from animal cells instead of slaughtered animals.

The promise is straightforward: real meat, no slaughter required. You could eat beef without killing cattle, chicken without industrial farming, steak without ethical compromise. The technology works. Federal regulators approved it as safe. And nearly a third of US states have banned it or are trying to. Not because it's dangerous -- because it threatens something deeper than food safety.

Start with a small sample of animal cells -- a biopsy, not a slaughter. Place them in a bioreactor with nutrients. The cells multiply, forming muscle tissue identical to conventional meat at the cellular level. Nutritionally comparable, same protein content, but grown without raising and killing an animal.

The process uses 64-90% less land than conventional meat production and drastically reduces greenhouse gas emissions. No factory farms, no slaughterhouses, no ethical compromise for people who love meat but hate industrial animal agriculture. For vegetarians who gave up meat for ethical reasons, it offers something impossible before: guilt-free steak.

[...] Here's where the dream hits reality. Consumer surveys show people perceive conventional meat as tastier and healthier than lab-grown alternatives. Fewer consumers are willing to try cultivated options than expected. The words "lab-grown" and "cultivated" don't exactly make mouths water.

Something about meat grown in a bioreactor triggers deep discomfort for many people, even those who claim to care about animal welfare and environmental impact. It's the same psychological barrier that made "Frankenfood" stick as a label for GMOs. Meat is supposed to come from animals, raised on farms, connected to land and tradition. Growing it in a facility feels wrong to people in ways they struggle to articulate.

The Food and Drug Administration has reversed its decision on Moderna's flu vaccine and has agreed to review it for possible approval, Moderna announced on Wednesday. From a report: Last week, the agency rejected Moderna's application for review of a new flu vaccine, saying the company's research design was flawed. But in subsequent discussions the company said that the agency had relented and agreed to begin a review.

Moderna said it split its application for the flu vaccine based on age, seeking a traditional approval for people 50 to 64 years old, and accelerated approval for those 65 and older. The company also said it agreed to conduct an additional study among those 65 and older once the vaccine reached the market. Moderna said on Wednesday that the F.D.A. set a deadline of August to decide whether to approve the vaccine. If it is authorized, it would be available for those older adults in the flu season that begins later this year.

The vaccine uses messenger RNA technology, which Health Secretary Robert F. Kennedy Jr. has repeatedly criticized as unsafe and ineffective. The mRNA approach, which instructs the body to produce a fragment of a virus that sets off an immune response, was widely successful in Covid vaccines and is considered generally safe by public health experts and scientists.

In a small double-blind clinical trial, a single intravenous dose of DMT produced rapid and clinically meaningful reductions in symptoms of major depressive disorder within a week, with effects lasting up to three months in some patients. "Unlike psilocybin and lysergic acid diethylamide ( LSD), whose effects can last for hours, intravenous DMT has a half-life of around five minutes," notes ScienceAlert. "Its psychedelic effects are correspondingly brief, potentially making it more practical to administer in clinical settings." From the report: "A single dose of DMT with psychotherapeutic support produced a rapid, significant reduction in depressive symptoms, sustained up to three months," writes a team led by neuroscientists David Erritzoe and Tommaso Barba of Imperial College London. [...] They recruited 34 participants with major depression and divided them into two groups of 17 for a double-blind, placebo-controlled trial.

In the first stage of the trial, one group received an intravenous dose of DMT, while the other received an active placebo. Neither the researchers nor the participants were informed which participants received the DMT. The doses took around 10 minutes to administer, and a therapist sat with each participant to ensure comfort and safety while the psychedelic effects were active, remaining silent throughout the treatment. The treatment was generally well tolerated. Most side effects were mild to moderate, and included nausea, temporary anxiety, and pain at the injection site. No serious adverse events related to the treatment were reported, although brief increases in heart rate and blood pressure were observed immediately after dosing.

In the second, open-label stage, two weeks after the first dose, all participants were given the opportunity to receive a dose of DMT. Participants were assessed before and at intervals after each dose using the Montgomery-Asberg Depression Rating Scale. Just a week after the first dose, participants who had received DMT had improved scores compared to the placebo group, and improvements were sustained during follow-up assessments.

Two weeks after the first dose, the participants who received DMT scored about seven points lower, on average, than those who received a placebo. On this commonly used clinical scale, a drop of that size is generally considered a meaningful reduction in symptom severity. There was no significant difference between patients who received one or two doses of DMT, suggesting a single dose may be sufficient. These effects persisted for up to three months, and some patients remained in remission for at least six months following the treatment. The findings have been published in Nature Medicine.

Longtime Slashdot reader walterbyrd shares a report from ABC News: In a study of nearly 28 million older Americans, long-term exposure to fine particle air pollution raised the risk of Alzheimer's disease. That link held even after researchers accounted for common conditions like high blood pressure, stroke and depression. Fine particle air pollution, known as PM2.5, consists of tiny particles in the air that come from car exhaust, power plants, wildfires, and burning fuels, according to the American Lung Association. They are small enough to travel deep into the lungs and even reach the bloodstream.

The research, conducted at Emory University and published in PLOS Medicine, tracked health data over nearly two decades to explore whether air pollution harms the brain indirectly by causing high blood pressure or heart disease, which, in turn, leads to dementia. However, these "middleman" conditions accounted for less than 5% of the connection between pollution and Alzheimer's, the research found. The researchers say this suggests that over 95% of the Alzheimer's risk comes from the direct impact of breathing in dirty air, likely through inflammation or damage to brain cells. "The relationship between PM2.5 and AD [Alzheimer's disease] has been shown to be pretty much linear," said Kyle Steenland, a professor in the departments of environmental health and epidemiology at the Rollins School of Public Health at Emory University, and senior author of the study. "The reason this is particularly important is that PM2.5 is known to be associated with high blood pressure, stroke and depression -- all of which are associated with AD. So, from a prevention standpoint, simply treating these diseases will not get rid of the problem. We have to address exposure to PM2.5."

Up to a third of people worldwide have shoulder pain; it's one of the most common musculoskeletal complaints. But medical imaging might not reveal the problem -- in fact, it could even cloud it. From a report: In a study published in JAMA Internal Medicine this week, 99 percent of adults over 40 were found to have at least one abnormality in a rotator cuff on magnetic resonance imaging (MRI). The rotator cuff is the group of muscles and tendons in a shoulder joint that keeps the upper arm bone securely in the shoulder socket -- and is often blamed for pain and other symptoms.

The trouble is, the vast majority of the people in the study had no problems with their shoulders. The finding calls into question the growing use of MRIs to try to diagnose shoulder pain -- and, in turn, the growing problem of overtreatment of rotator cuff (RC) abnormalities, which includes partial- and full-thickness tears as well as signs of tendinopathy (tendon swelling and thickening). "While we cannot dismiss the possibility that some RC tears may contribute to shoulder symptoms, our findings indicate that we are currently unable to distinguish clinically meaningful MRI abnormalities from incidental findings," the study authors concluded.

Researchers performed genome sequencing scans on 130 people whose fathers were Chernobyl cleanup workers. Comparing the scans to control groups, they found evidence for the first time for "a transgenerational effect" from the father's prolonged exposure to low-dose ionizing radiation.

ScienceAlert reports: Rather than picking out new DNA mutations in the next generation, they looked for what are known as clustered de novo mutations (cDNMs): two or more mutations in close proximity, found in the children but not the parents. These would be mutations resulting from breaks in the parental DNA caused by radiation exposure. "We found a significant increase in the cDNM count in offspring of irradiated parents, and a potential association between the dose estimations and the number of cDNMs in the respective offspring," write the researchers in their published paper... This fits with the idea that radiation creates molecules known as reactive oxygen species, which are able to break DNA strands — breaks which can leave behind the clusters described in this study, if repaired imperfectly.

The good news is that the risk to health should be relatively small: children of exposed parents weren't found to have any higher risk of disease. This is partly because a lot of the cDNMs likely fall in 'non-coding' DNA, rather than in genes that directly encode proteins.

Two astrophysicists at Spain's Instituto de Astrofísica de Canarias analyzed data from the James Webb Space Telescope — the most powerful telescope available — on 31 galaxies with an average redshift of 7.3 (when the universe was 700 million years old, according to the standard model). "We found that they are on average ~600 million years old old, according to the comparison with theoretical models based on previous knowledge of nearby galaxies..."

"If this result is correct, we would have to think about how it is possible that these massive and luminous galaxies were formed and started to produce stars in a short time. It is a challenge."

But "The fact that some of these galaxies might be older than the universe, within some significant confidence level, is even more challenging." The most extreme case is for the galaxy JADES-1050323 with redshift 6.9, which has, according to my calculation, an age incompatible to be younger than the age of the universe (800 million years) within 4.7-sigma (that is, a probability that this happens by chance as statistical fluctuation of one in one million).

If this result is confirmed, it would invalidate the standard Lambda-CDM cosmological model. Certainly, such an extraordinary change of paradigm would require further corroboration and other stronger evidence. Anyway, it would be interesting for other researchers to try to explain the Spectral Energy Distribution of JADES-1050323 in standard terms, if they can ... and without introducing unrealistic/impossible models of extinction, as is usually done.
The findings are published in the journal Monthly Notices of the Royal Astronomical Society.

"Research published in the World Journal of Men's Health found evidence that drugs such as Viagra and Cialis may also help with heart disease, stroke risk and diabetes," reports the Telegraph, "as well as enlarged prostate and urinary problems." Researchers found evidence that the same mechanism may benefit other organs, including the heart, brain, lungs and urinary system. The paper reviewed a wide range of published studies [and] identified links between PDE5 inhibitor use and improvements in cardiovascular health. Heart conditions were repeatedly cited as an area where improved blood flow and muscle relaxation may offer benefits. Evidence also linked PDE5 inhibitors with reduced stroke risk, likely to be related to improved circulation and vascular function. Diabetes was another condition where associations with improvement were identified... The review also found evidence of benefit for men with an enlarged prostate, a condition that commonly causes urinary symptoms.

An anonymous reader shares a report: The Food and Drug Administration has refused to start a review of Moderna's application for its experimental flu shot, the company announced Tuesday, in another sign of the Trump administration's influence on tightening vaccine regulations in the U.S. Moderna said the move is inconsistent with previous feedback from the agency from before it submitted the application and started phase three trials on the shot, called mRNA-1010. The drugmaker said it has requested a meeting with the FDA to "understand the path forward."

Moderna noted that the agency did not identify any specific safety or efficacy issues with the vaccine, but instead objected to the study design, despite previously approving it. The company added that the move won't impact its 2026 financial guidance. Moderna's jab showed positive phase three data last year, meeting all of the trial goals. At the time, Moderna said the stand-alone flu shot was key to its efforts to advance a combination vaccine targeting both influenza and Covid-19.

An anonymous reader shares a report: In 1966, a beach-ball-size robot bounced across the moon. Once it rolled to a stop, its four petal-like covers opened, exposing a camera that sent back the first picture taken on the surface of another world. This was Luna 9, the Soviet lander that was the earliest spacecraft to safely touchdown on the moon. While it paved the way toward interplanetary exploration, Luna 9's precise whereabouts have remained a mystery ever since.

That may soon change. Two research teams think they might have tracked down the long-lost remains of Luna 9. But there's a catch: The teams do not agree on the location. "One of them is wrong," said Anatoly Zak, a space journalist and author who runs RussianSpaceWeb.com and reported on the story last week. The dueling finds highlight a strange fact of the early moon race: The precise resting places of a number of spacecraft that crashed or landed on the moon in the run up to NASA's Apollo missions are lost to obscurity. A newer generation of spacecraft may at last resolve these mysteries.

Luna 9 launched to the moon on Jan. 31, 1966. While a number of spacecraft had crashed into the lunar surface at that stage of the moon race, it was among the earliest to try what rocket engineers call a soft landing. Its core unit, a spherical suite of scientific instruments, was about two feet across. That size makes it difficult to spot from orbit. "Luna 9 is a very, very small vehicle," said Mark Robinson, a geologist at the company Intuitive Machines, which has twice landed spacecraft on the moon.

If you think your daily doses of espresso or Earl Grey sharpen your mind, you just might be right, new science suggests. The New York Times: A large new study provides evidence of cognitive benefits from coffee and tea -- if it's caffeinated and consumed in moderation: two to three cups of coffee or one to two cups of tea daily.

People who drank that amount for decades had lower chances of developing dementia than people who drank little or no caffeine, the researchers reported. They followed 131,821 participants for up to 43 years. "This is a very large, rigorous study conducted long term among men and women that shows that drinking two or three cups of coffee per day is associated with reduced risk of dementia," said Aladdin Shadyab, an associate professor of public health and medicine at the University of California, San Diego, who wasn't involved in the study.

The findings, published Monday in JAMA, don't prove caffeine causes these beneficial effects, and it's possible other attributes protected caffeine drinkers' brain health. But independent experts said the study adjusted for many other factors, including health conditions, medication, diet, education, socioeconomic status, family history of dementia, body mass index, smoking and mental illness.

"Elon Musk said on Sunday that SpaceX has shifted its focus to building a 'self-growing city' on the moon," reports Reuters, "which could be achieved in less than 10 years." SpaceX still intends to start on Musk's long-held ambition of a city on Mars within five to seven years, he wrote on his X social media platform, "but the overriding priority is securing the future of civilization and the Moon is faster."

Musk's comments echo a Wall Street Journal report on Friday, stating that SpaceX has told investors it would prioritize going to the moon and attempt a trip to Mars at a later time, targeting March 2027 for an uncrewed lunar landing. As recently as last year, Musk said that he aimed to send an uncrewed mission to Mars by the end of 2026.

As Super Bowl Sunday comes to a close, America's National Football League "is challenging innovators to improve the facemask on football helmets to reduce concussions in the game," reports the Associated Press: The league announced on Friday at an innovation summit for the Super Bowl the next round in the HealthTECH Challenge series, a crowdsourced competition designed to accelerate the development of cutting-edge football helmets and new standards for player safety. The challenge invites inventors, engineers, startups, academic teams and established companies to improve the impact protection and design of football helmets through improvements to how facemasks absorb and reduce the effects of contact on the field...

Most progress on helmet safety has come from improvements to the shell and padding, helping to reduce the overall rate of concussions. Working with the helmet industry, the league has brought in position-specific helmets, with those for quarterbacks, for example, having more padding in the back after data showed most concussions for QBs came when the back of the head slammed to the turf. But the facemask has mostly remained the same. This past season, 44% of in-game concussions resulted from impact to the player's facemask, up from 29% in 2015, according to data gathered by the NFL. "What we haven't seen over that period of time are any changes of any note to the facemask," [said Jeff Miller, the NFL's executive vice president overseeing player health and safety]... "Now we see, given the changes in our concussion numbers and injuries to players, that as changes are made to the helmet, fewer and fewer concussions are caused by hits to the shell, and more and more concussions as a percentage are by hits to the facemask..."

Selected winners will receive up to $100,000 in aggregate funding, as well as expert development support to help move their concepts from the lab to the playing field.
Winners will be announced in August, according to the article, "and Miller said he expected helmet manufacturers to start implementing any improvements into helmets soon after that."

"A spectacular trove of fossils discovered in a cave on New Zealand's North Island has given scientists their first glimpse of ancient forest species that lived there more than a million years ago," reports Popular Mechanics: The fossils represent 12 ancient bird species and four frog species, including several previously unknown bird species. Taken together, the fossils paint a picture of an ancient world that looks drastically different than it does today. The discovery also fills in an important gap in scientific understanding of the patterns of extinction that preceded human arrival in New Zealand 750 years ago. The team published a study on the find in Alcheringa: An Australasian Journal of Palaeontology.
Trevor Worthy, lead study author and associate professor at Flinders University, said in a statement that "This remarkable find suggests our ancient forests were once home to a diverse group of birds that did not survive the next million years...

"For decades, the extinction of New Zealand's birds was viewed primarily through the lens of human arrival 750 years ago. This study proves that natural forces like super-volcanoes and dramatic climate shifts were already sculpting the unique identity of our wildlife over a million years ago."

Thanks to long-time Slashdot reader fahrbot-bot for sharing the article.

2001: "Brookhaven Labs has produced for the first time collisions of gold nuclei at a center of mass energy of 200GeV/nucleon."

2002: "There may be a new type of matter according to researchers at Brookhaven National Laboratory."

2010: The hottest man-made temperatures ever achived were a record 4 trillion degree plasma experiment at Brookhaven National Laboratory in New York... anointed the Guinness record holder."

2023: "Scientists at Brookhaven National Laboratory have uncovered an entirely new kind of quantum entanglement."


2026: On Friday, February 6, "a control room full of scientists, administrators and members of the press gathered" at the Relativistic Heavy Ion Collider (RHIC) at Brookhaven National Lab in Upton, New York to witness its final collisions, reports Scientific American: The vibe had been wistful, but the crowd broke into applause as Darío Gil, the Under Secretary for Science at the U.S. Department of Energy, pressed a red button to end the collider's quarter-century saga... "I'm really sad" [said Angelika Drees, a BNL accelerator physicist]. "It was such a beautiful experiment and my research home for 27 years. But we're going to put something even better there."

That "something" will be a far more powerful electron-ion collider to further push the frontiers of physics, extend RHIC's legacy and maintain the lab's position as a center of discovery. This successor will be built in part from RHIC's bones, especially from one of its two giant, subterranean storage rings that once held the retiring collider's supply of circulating, near-light speed nuclei...slated for construction over the next decade. [That Electron-Ion Collider, or EIC] will utilize much of RHIC's infrastructure, replacing one of its ion rings with a new ring for cycling electrons. The EIC will use those tiny, fast-flying electrons as tiny knives for slicing open the much larger gold ions. Physicists will get an unrivaled look into the workings of quarks and gluons and yet another chance to grapple with nature's strongest force. "We knew for the EIC to happen, RHIC needed to end," says Wolfram Fischer, who chairs BNL's collider-accelerator department. "It's bittersweet."

EIC will be the first new collider built in the US since RHIC. To some, it signifies the country's reentry into a particle physics landscape it has largely ceded to Europe and Asia over the past two decades. "For at least 10 or 15 years," says Abhay Deshpande, BNL's associate laboratory director for nuclear and particle physics, "this will be the number one place in the world for [young physicists] to come."
The RHIC was able "to separately send two protons colliding with precisely aligned spins — something that, even today, no other experiment has yet matched," the article points out: During its record-breaking 25-year run, RHIC illuminated nature's thorniest force and its most fundamental constituents. It created the heaviest, most elaborate assemblages of antimatter ever seen. It nearly put to rest a decades-long crisis over the proton's spin. And, of course, it brought physicists closer to the big bang than ever before...

When RHIC at last began full operations in 2000, its initial heavy-ion collisions almost immediately pumped out quark-gluon plasma. But demonstrating this beyond a shadow of a doubt proved in some respects more challenging than actually creating the elusive plasma itself, with the case for success strengthening as RHIC's numbers of collisions soared. By 2010 RHIC's scientists were confident enough to declare that the hot soup they'd been studying for a decade was hot and soupy enough to convincingly constitute a quark-gluon plasma. And it was even weirder than they thought. Instead of the gas of quarks and gluons theorists expected, the plasma acted like a swirling liquid unprecedented in nature. It was nearly "perfect," with zero friction, and set a new record for twistiness, or "vorticity." For Paul Mantica, a division director for the Facilities and Project Management Division in the DOE's Office of Nuclear Physics, this was the highlight of RHIC's storied existence. "It was paradigm-changing," he says...

Data from the final run (which began nearly a year ago) has already produced yet another discovery: the first-ever direct evidence of "virtual particles" in RHIC's subatomic puffs of quark-gluon plasma, constituting an unprecedented probe of the quantum vacuum.
RHIC's last run generated hundreds of petabytes of data, the article points out, meaning its final smash "isn't really the end; even when its collisions stop, its science will live on."

But Science News notes RHIC's closure "marks the end for the only particle collider operating in the United States, and the only collider of its kind in the world. Most particle accelerators are unable to steer two particle beams to crash head-on into one another."