Mark Thomson, a professor of experimental particle physics at the University of Cambridge, takes over as CERN's director general this week, and one of his first major decisions during his five-year tenure will be shutting down the Large Hadron Collider for an extended upgrade. The shutdown starts in June to make way for the high-luminosity LHC -- a major overhaul involving powerful new superconducting magnets that will squeeze the collider's proton beams and increase their brightness. The upgrade will raise collisions tenfold and strengthen the detectors to better capture subtle signs of new physics. The machine won't restart until Thomson's term is nearly over.

Thomson is far from disconsolate about the downtime. "The machine is running brilliantly and we're recording huge amounts of data," he told The Guardian. "There's going to be plenty to analyse over the period." Beyond the upgrade, Thomson must shepherd CERN's plans for the Future Circular Collider, a proposed 91km machine more than three times the size of the current collider. Member states vote on the project in 2028; the first phase carries an estimated price tag of 15 billion Swiss francs (nearly $19 billion).

A UK-based company has successfully powered up a microwave-sized space factory in orbit, proving it can run a 1,000C furnace to manufacture ultra-pure semiconductor materials in microgravity. "The work that we're doing now is allowing us to create semiconductors up to 4,000 times purer in space than we can currently make here today," says Josh Western, CEO of Space Forge. "This sort of semiconductor would go on to be in the 5G tower in which you get your mobile phone signal, it's going to be in the car charger you plug an EV into, it's going to be in the latest planes." The BBC reports: Conditions in space are ideal for making semiconductors, which have the atoms they're made of arranged in a highly ordered 3D structure. When they are being manufactured in a weightless environment, those atoms line up absolutely perfectly. The vacuum of space also means that contaminants can't sneak in. The purer and more ordered a semiconductor is, the better it works.

[...] The company's mini-factory launched on a SpaceX rocket in the summer. Since then the team has been testing its systems from their mission control in Cardiff. Veronica Viera, the company's payload operations lead, shows us an image that the satellite beamed back from space. It's taken from the inside of the furnace, and shows plasma - gas heated to about 1,000C -- glowing brightly. [...]

The team is now planning to build a bigger space factory -- one that could make semiconductor material for 10,000 chips. They also need to test the technology to bring the material back to Earth. On a future mission, a heat shield named Pridwen after the legendary shield of King Arthur will be deployed to protect the spacecraft from the intense temperatures it will experience as it re-enters the Earth's atmosphere.

NASA is closing its largest research library at the Goddard Space Flight Center amid budget cuts and campus consolidation, putting tens of thousands of largely non-digitized historical and scientific documents at risk of being warehoused or discarded. The New York Times reports: Jacob Richmond, a NASA spokesman, said the agency would review the library holdings over the next 60 days and some material would be stored in a government warehouse while the rest would be tossed away. "This process is an established method that is used by federal agencies to properly dispose of federally owned property," Mr. Richmond said.

The shutdown of the library at NASA's Goddard Space Flight Center in Greenbelt, Md., is part of a larger reorganization under the Trump administration that includes the closure of 13 buildings and more than 100 science and engineering laboratories on the 1,270-acre campus by March 2026. "This is a consolidation not a closure," said NASA spokeswoman Bethany Stevens. The changes were part of a long-planned reorganization that began before the Trump administration took office, she said. She said that shutting down the facilities would save $10 million a year and avoid another $63.8 million in deferred maintenance.

Goddard is the nation's premiere spaceflight complex. Its website calls it "the largest organization of scientists, engineers, and technologists who build spacecraft, instruments, and new technology to study Earth, the Sun, our solar system, and the universe." [...] The library closure on Friday follows the shutdown of seven other NASA libraries around the country since 2022, and included three libraries this year. As of next week, only three -- at the Glenn Research Center in Cleveland, the Ames Research Center in Mountain View, Calif., and the Jet Propulsion Laboratory in Pasadena, Calif. -- will remain open.

An anonymous reader quotes a report from the New York Times: For a while, it seemed the notion that light drinking was good for the heart had gone by the wayside, debunked by new studies and overshadowed by warnings that alcohol causes cancer. Now the American Heart Association has revived the idea in a scientific review that is drawing intense criticism, setting off a new round of debate about alcohol consumption. The paper, which sought to summarize the latest research and was aimed at practicing cardiologists, concluded that light drinking -- one to two drinks a day -- posed no risk for coronary disease, stroke, sudden death and possibly heart failure, and may even reduce the risk of developing these conditions.

Controversy over the influential organization's review has been simmering since it was published in the association's journal Circulation in July. Public health groups and many doctors have warned on the basis of recent studies that alcohol can be harmful even in small amounts. Groups like the European Heart Network and the World Heart Federation have stressed that even modest drinking increases the odds of cardiovascular disease. "It says in all our guidelines right now, 'If you don't drink, don't start.' There's not enough evidence to suggest conclusively that it prevents heart disease," said Dr. Mariell Jessup, the chief science and medical officer at the heart association, adding that the review was not meant to serve as a guideline and that the group's advice to patients has not changed.

Critics argue that suggesting any heart-health benefits from alcohol is dangerous given its well-documented risks, and they accuse the heart association of selectively weighing studies. They also say a past tie to the alcohol industry by one author should have disqualified him from participating.

"The cardiovascular benefits of moderate drinking are questionable at best," said Dr. Elizabeth Farkouh, an internist and alcohol researcher. "But even if there was a benefit, there are so many other ways to reduce cardiovascular risk that don't come with an associated cancer risk."

The new review's conclusion is also at odds with the CDC's guidance on alcohol, which notes that "even moderate drinking may increase your risk of death and other alcohol-related harms, compared to not drinking." It also seems to diverge from the heart association's diet and lifestyle recommendation to consume "limited or preferably no alcohol," along with its 2023 statement that recent research suggests there is "no safe level of alcohol use."

The Wall Street Journal reports that a growing number of tech startups are stocking offices with free nicotine pouches as founders and employees chase sharper focus and stamina in hyper-competitive AI-era work environments. The Wall Street Journal reports: Earlier this year, two nicotine startups -- Lucy Nicotine and Sesh -- made branded vending machines filled with flavored products for analytics company Palantir Technologies. Both machines are in the company's Washington, D.C., offices. The pouches are free for employees and guests over the age of 21, a spokeswoman for Palantir said. Palantir pays to stock the nicotine products.

Alex Cohen, a startup founder based in Austin, Texas, said he was first exposed to nicotine pouches in the workplace after seeing tins of Zyns on the desks of his software engineers. His company, Hello Patient, makes AI-powered healthcare-communication software. "They were very productive, so I thought maybe there's something here," he said. Those engineers soon asked him if he could buy it for the office.

Cohen said he initially bought the nicotine pouches as a joke for social media. He posted a picture of a drawer in his startup's office filled with nicotine pouches made by different brands with the caption, "We're hiring." "Then, I accidentally got addicted," said Cohen. He said he uses around two to three pouches a day. His go-to flavors are mango or minty. Cohen said he has attention-deficit/hyperactivity disorder, or ADHD, and he has found that the pouches can provide a quick productivity boost. "It helps with reining in my focus because it is a stimulant," he said. Today, Hello Patient has a nicotine-pouch fridge in its office kitchen.

An anonymous reader shares a report: Getting to space is hard. In many ways, getting back is even harder. NASA soon aims to pull off the kind of re-entry it last conducted more than 50 years ago: safely returning astronauts to Earth after they fly to the moon and back. The mission is a big moment for NASA, which will put a crew on its Orion ship for the first time. The flight will test the spacecraft's heat shield, designed to protect the astronauts on board.

Re-entries of vehicles from orbit remain one of the high-stakes parts of any human spaceflight, given the stress they put on spacecraft. In 2003, NASA's Columbia Space Shuttle broke apart as it came back from low-Earth orbit due to a breach on the vehicle that occurred during launch. All seven astronauts on board were killed. Orion will be coming back to Earth from much further away than low-Earth orbit, where all recent human spaceflights have been conducted. That means its velocity and the energy it needs to disperse will be greater, putting even more stress on the heat shield.

During a test flight in 2022 that didn't include astronauts, Orion's heat shield didn't perform as expected. That sparked worries about crew safety on future missions, prompting NASA to investigate and address what happened. NASA will launch Orion with the astronauts on board as soon as February. [...] When the vehicle initially re-enters the Earth's atmosphere, it will be traveling around 25,000 miles an hour and face temperatures of 5,000 degrees as it slows down. The Orion craft, developed by Lockheed Martin for NASA, has a shield that is almost 17 feet in diameter. Installed on the vehicle's underside, the shield is covered in what is called an "ablative" material, which is designed to shift heat away from the craft during re-entry by burning off in a controlled manner.

A large-scale study tracking more than 27,500 middle-aged and elderly people over roughly nine years has found that poor sleep quality is associated with accelerated brain aging, and chronic inflammation appears to be one of the key mechanisms driving this effect.

Researchers at Sweden's Karolinska Institute assessed participants' sleep across five dimensions -- chronotype, duration, insomnia, snoring and daytime sleepiness -- and later scanned their brains using MRI to estimate biological brain age through machine learning models. The results? For every point decrease in healthy sleep score, the gap between brain age and chronological age widened by approximately six months. Those in the poorest sleep category had brains that appeared roughly one year older than their actual age.

Night-owl tendencies, sleep duration outside the 7-8 hour sweet spot and snoring were particularly strongly linked to brain aging. The researchers measured low-grade inflammation using biomarkers including C-reactive protein levels and white blood cell counts. Inflammation accounted for more than 10% of the association between poor sleep patterns and brain aging. The glymphatic system, which clears waste from the brain primarily during sleep, may also play a role, the research added.

Colossal Biosciences, the Texas-based startup now valued at more than $10 billion that has attracted investments from Paris Hilton, Peter Jackson and Tom Brady, claimed earlier this year to have resurrected the dire wolf -- an animal that disappeared at the end of the last ice age -- but a group of leading canid experts concluded the company had done no such thing.

The scientists found that Colossal had made 20 edits to the DNA of grey wolves and the resulting animals did not substantially differ from wolves currently roaming North America. Beth Shapiro, Colossal's own chief scientist, acknowledged to New Scientist: "It's not possible to bring something back that is identical to a species that used to be alive. Our animals are grey wolves with 20 edits that are cloned."

Nic Rawlence, director of the palaeogenetics laboratory at the University of Otago in New Zealand, added: "Rather than true de-extinction, Colossal's attempts are genetically engineered poor copies at best, passed off as the real deal."

The company has nevertheless pressed forward. It has launched projects to revive the Tasmanian tiger, the dodo, and the moa and plans to unveil its interpretation of the woolly mammoth -- a genetically modified Asian elephant adapted to survive at -40C -- in the coming years. The Trump administration cited the dire wolf announcement while making efforts to cut the US endangered species list, calling de-extinction technology a potential "bedrock for modern species conservation."

The U.S. has surpassed 2,000 measles cases for the first time in more than 30 years, according to data from the Centers for Disease Control and Prevention. From a report: As of Dec. 23, a total of 2,012 cases have been reported in the U.S. Of those cases, 24 were reported among international visitors to the U.S.

A study by a Singapore government agency has found that children exposed to high levels of screen time before age two showed brain development changes linked to slower decision-making and higher anxiety in adolescence, adding to concerns about early digital exposure. From a report: The study was conducted by a team within the country's Agency for Science, Technology and Research and the National University of Singapore, and published in The Lancet's eBioMedicine open access journal. It tracked 168 children for more than a decade, and conducted brain scans on them at three time points. Heavier screen exposure among very young children was associated with "accelerated maturation of brain networks" responsible for vision and cognitive control, the study found.

The researchers suggested this may have been the result of "intense sensory stimulation that screens provide." They found that screen time measured at ages three and four, however, did not show the same effects. Those children with "altered brain networks" took longer to make decisions when they were 8.5, and also had higher anxiety symptoms at age 13, the study said.

The World Health Organization's latest annual malaria report paints a grim picture that's about to get grimmer, as the United States -- which has supplied 37% of global malaria funding since 2010 -- pulls back its international health commitments under President Donald Trump. Malaria cases have been climbing since 2015, when progress against the mosquito-borne disease stalled due to insecticide resistance and chronic underfunding.

In 2024, the world recorded 282 million cases and 610,000 deaths, and African countries accounted for 95% of both figures. Children under 5 made up 75% of malaria-related deaths in Africa. Global spending on malaria reached $3.9 billion last year.

Trump's decision to slash international public health funding and gut the US Agency for International Development has caused what the WHO calls "widespread disruption to health operations around the world." The burden of these setbacks, the organization adds, is expected to fall disproportionately on children. Seventeen countries now offer malaria vaccines to younger populations, up from three countries the year before, but funding constraints mean many countries still can't provide the shots.

The Wall Street Journal reports that Boston's once-booming biotech sector has hit a sharp downturn, leaving newly minted Ph.D.s struggling to find work as venture funding dries up, lab space sits empty, and companies downsize or relocate amid rising costs and policy uncertainty. The Wall Street Journal reports: Boston's biotech sector, long a vital economic engine for one of America's wealthiest metro areas, is sputtering. A double whammy of cutbacks in venture capital and government funding have taken a toll, leading to layoffs and struggles for job seekers. For workers who thought they would easily launch into a well-paying science career, the downturn has been especially harsh.

Massachusetts experienced a slight decline in its roughly 65,000 biotech research-and-development jobs in 2024 after years of mostly strong increases, including during the Covid-19 pandemic, according to federal data. The numbers indicate that job losses continued through at least June, while hiring remains sluggish. By the end of September, nearly 28% of greater Boston's laboratory space sat empty, according to the latest estimates from real-estate firm CBRE. "Every stage of the life cycle has been impacted by policy or regulatory uncertainty this year," said Kendalle Burlin O'Connell, chief executive of MassBio, an industry trade group. The impact has hit startups especially hard, she said.

A continued downturn poses risks for a region where workers will put up with sky-high real-estate costs if they can land high-paying jobs. Massachusetts faces competition from other states and China, which are eager to peel away talent and investment. "There are states and countries chasing us every single day," Gov. Maura Healey said in an interview. In late October, the Democrat testified before the Massachusetts legislature in support of a $400 million "competitiveness agenda" that she is seeking to spur new investment and supplement research funding lost this year. Lawmakers are reviewing the bill, a House spokesman said.

Stingless bees from the Amazon have become the first insects to be granted legal rights anywhere in the world, in a breakthrough supporters hope will be a catalyst for similar moves to protect bees elsewhere. From a report: It means that across a broad swathe of the Peruvian Amazon, the rainforest's long-overlooked native bees -- which, unlike their cousins the European honeybees, have no sting -- now have the right to exist and to flourish. Cultivated by Indigenous peoples since pre-Columbian times, stingless bees are thought to be key rainforest pollinators, sustaining biodiversity and ecosystem health.

But they are faced with a deadly confluence of climate change, deforestation and pesticides, as well as competition from European bees, and scientists and campaigners have been racing against time to get stingless bees on international conservation red lists. Constanza Prieto, Latin American director at the Earth Law Center, who was part of the campaign, said: "This ordinance marks a turning point in our relationship with nature: it makes stingless bees visible, recognises them as rights-bearing subjects, and affirms their essential role in preserving ecosystems."

An anonymous reader shared this report from the BBC: There is growing controversy over recent evidence suggesting that a mysterious force known as dark energy might be changing in a way that challenges our current understanding of time and space. An analysis by a South Korean team has hinted that, rather than the Universe continuing to expand, galaxies could be pulled back together by gravity, ending in what astronomers call a "Big Crunch".

The scientists involved believe that they may be on the verge of one of the biggest discoveries in astronomy for a generation. Other astronomers have questioned these findings, but these critics have not been able to completely dismiss the South Korean team's assertions...

The controversy began in March with unexpected results from an instrument on a telescope in the Arizona desert called the Dark Energy Spectroscopic Instrument (Desi)... The data hinted that acceleration of the galaxies had changed over time, something not in line with the standard picture, according to Prof Ofer Lehav of University College London, who is involved with the Desi project. "Now with this changing dark energy going up and then down, again, we need a new mechanism. And this could be a shake up for the whole of physics," he says. Then in November the Royal Astronomical Society (RAS) published research from a South Korean team that seems to back the view that the weirdness of dark energy is weirder still.

Prof Young Wook Lee of Yonsei University in Seoul and his team went back to the kind of supernova data that first revealed dark energy 27 years ago. Instead of treating these stellar explosions as having one standard brightness, they adjusted for the ages of the galaxies they came from and worked out how bright the supernovas really were. This adjustment showed that not only had dark energy changed over time, but, shockingly, that the acceleration was slowing down... If, as Prof Lee's results suggest, the force that is pushing galaxies away from each other — dark energy — is weakening, then one possibility is that it becomes so weak that gravity begins to pull the galaxies back together.

An anonymous reader shared this report from the Associated Press: Two NATO-nation intelligence services suspect Russia is developing a new anti-satellite weapon to target Elon Musk's Starlink constellation with destructive orbiting clouds of shrapnel, with the aim of reining in Western space superiority that has helped Ukraine on the battlefield. Intelligence findings seen by The Associated Press say the so-called "zone-effect" weapon would seek to flood Starlink orbits with hundreds of thousands of high-density pellets, potentially disabling multiple satellites at once but also risking catastrophic collateral damage to other orbiting systems.

Analysts who haven't seen the findings say they doubt such a weapon could work without causing uncontrollable chaos in space for companies and countries, including Russia and its ally China, that rely on thousands of orbiting satellites for communications, defense and other vital needs. Such repercussions, including risks to its own space systems, could steer Moscow away from deploying or using such a weapon, analysts said. "I don't buy it. Like, I really don't," said Victoria Samson, a space-security specialist at the Secure World Foundation who leads the Colorado-based nongovernmental organization's annual study of anti-satellite systems. "I would be very surprised, frankly, if they were to do something like that." [Later they suggested the research might just be experimental.]

But the commander of the Canadian military's Space Division, Brig. Gen. Christopher Horner, said such Russian work cannot be ruled out in light of previous U.S. allegations that Russia also has been pursuing an indiscriminate nuclear, space-based weapon. "I can't say I've been briefed on that type of system. But it's not implausible," he said... The French military's Space Command said in a statement to the AP that it could not comment on the findings but said, "We can inform you that Russia has, in recent years, been multiplying irresponsible, dangerous, and even hostile actions in space."
The article also points out that this month Russia "said it has fielded a new ground-based missile system, the S-500, which is capable of hitting low-orbit targets..."