Biotech

Human Brain Cells On a Chip Learned To Play Doom In a Week (newscientist.com) 11

Researchers at Cortical Labs used living human neurons grown on a chip to learn how to play Doom in about a week. "While its performance is not up to par with humans, experts say it brings biological computers a step closer to useful real-world applications, like controlling robot arms," reports New Scientist. From the report: In 2021, the Australian company Cortical Labs used its neuron-powered computer chips to play Pong. The chips consisted of clumps of more than 800,000 living brain cells grown on top of microelectrode arrays that can both send and receive electrical signals. Researchers had to carefully train the chips to control the paddles on either side of the screen. Now, Cortical Labs has developed an interface that makes it easier to program these chips using the popular programming language Python. An independent developer, Sean Cole, then used Python to teach the chips to play Doom, which he did in around a week.

"Unlike the Pong work that we did a few years ago, which represented years of painstaking scientific effort, this demonstration has been done in a matter of days by someone who previously had relatively little expertise working directly with biology," says Brett Kagan of Cortical Labs. "It's this accessibility and this flexibility that makes it truly exciting."

The neuronal computer chip, which used about a quarter as many neurons as the Pong demonstration, played Doom better than a randomly firing player, but far below the performance of the best human players. However, it learnt much faster than traditional, silicon-based machine learning systems and should be able to improve its performance with newer learning algorithms, says Kagan. However, it's not useful to compare the chips with human brains, he says. "Yes, it's alive, and yes, it's biological, but really what it is being used as is a material that can process information in very special ways that we can't recreate in silicon."
Cortical Labs posted a YouTube video showing its CL1 biological computer running Doom. There's also source code available on GitHub, with additional details in a README file.
NASA

Nasa Announces Artemis III Mission No Longer Aims To Send Humans To Moon (theguardian.com) 69

Nasa announced on Friday radical changes to its delayed Artemis III mission to land humans back on the moon, as the US space agency grapples with technical glitches and criticism that it is trying to do too much too soon. From a report: The abrupt shift in strategy was laid out by the space agency's recently confirmed administrator, Jared Isaacman. Announcing the changes on Friday, he said that Nasa would introduce at least one new moon flight before attempting to put humans back on the lunar surface for the first time in more than half a century, in 2028.

The new, more incremental approach would give the Nasa team a chance to test flight and refine its technology. As part of the changes, the Artemis II mission to fly humans around the moon this year, without landing, would also be pushed back from its latest scheduled launch on 6 March to 1 April at the earliest.

"Everybody agrees this is the only way forward," Isaacman told reporters at a news conference. "I know this is how Nasa changed the world, and this is how Nasa is going to do it again."

Moon

Moon's Ancient Magnetic Field May Have Flickered On and Off (science.org) 11

sciencehabit quotes a report from Science Magazine: For decades, planetary scientists have pored over a mystery hidden within the Moon rocks retrieved by Apollo astronauts in the 1960s and '70s. Minerals in the rocks record the imprint of a magnetic field, nearly as powerful as Earth's, that existed more than 3.5 billion years ago and seemed to persist for millions of years. But generating a magnetic field requires a dynamo -- a churning, molten core -- and most researchers believed the Moon's tiny core would have long since cooled off, 1 billion years after it formed. Corroborating that picture are other ancient Moon rocks of about the same age that suggest the field was weak -- leaving planetary scientists baffled.

Now, researchers are proposing a new way to solve the puzzle. A paper published today in Nature Geoscience theorizes that between 3.5 billion and 4 billion years ago, blobs of titanium-rich magma melted episodically just above the core, rising in plumes that drove volcanic eruptions on the surface. By intermittently stirring up the Moon's core, these bouts of melting would have caused the Moon's magnetic field to flicker on in short, powerful bursts. The paper "links a few different concepts that people were thinking about separately, but hadn't actually brought together," says Sonia Tikoo, a planetary geophysicist at Stanford University who was not involved in the study.

NASA

NASA Reveals Identity of Astronaut Who Suffered Medical Incident Aboard ISS (nbcnews.com) 22

Longtime Slashdot reader ArchieBunker shares a report from NBC News: NASA revealed that astronaut Mike Fincke was the crew member who suffered a medical incident at the International Space Station in January, which prompted the agency to carry out the first evacuation due to a medical issue in the space station's 25-year history. The rare decision to cut a mission short and bring Fincke and three other crew members home early made for a dramatic week in space early this year.

In a statement released by NASA "at the request of Fincke," the veteran astronaut said he experienced a medical event on Jan. 7 "that required immediate attention" from his space station crew members. "Thanks to their quick response and the guidance of our NASA flight surgeons, my status quickly stabilized," Fincke, 58, said in the statement. [...] In his statement, Fincke thanked his Crew-11 colleagues, along with NASA astronaut Chris Williams and Russian cosmonauts Sergey Kud-Sverchkov and Sergei Mikaev, who were also aboard the space station at the time and are still in space. Fincke also thanked the teams at NASA, SpaceX and the medical professionals at Scripps Memorial Hospital La Jolla. "Their professionalism and dedication ensured a positive outcome," he said.

Fincke ended his statement by saying he is "doing very well" and still actively involved with standard post-flight reconditioning at NASA's Johnson Space Center in Houston. "Spaceflight is an incredible privilege, and sometimes it reminds us just how human we are," he said. "Thank you for all your support."

Science

Scientists Crack the Case of 'Screeching' Scotch Tape (arstechnica.com) 30

The screeching sound that Scotch tape makes when you rip it off a surface -- that fingernails-on-a-chalkboard noise most people try not to think about -- is produced by shock waves from micro-cracks that travel across the peeling tape at supersonic speeds, according to a new paper published in Physical Review E.

Researchers led by Sigurdur Thoroddsen of King Abdullah University in Saudi Arabia used simultaneous high-speed imaging and synchronized microphones to capture both the propagating fractures and the sound waves they generate in the surrounding air. The team's earlier work, in 2010, had identified a sequence of transverse cracks racing across the width of the adhesive during peeling, and a 2024 follow-up established a direct correspondence between those cracks and the screeching sound, but neither study pinpointed a mechanism.

The new findings show that a partial vacuum forms between the tape and the surface as each crack opens, and because the crack moves faster than air can rush in to fill the void, the vacuum travels along until it reaches the tape's edge and collapses into the stationary air outside, producing a discrete sound pulse.
Science

First British Baby Born Using Transplanted Womb From Dead Donor (bbc.com) 67

A 10-week-old boy named Hugo has become the first baby born in the UK from a womb transplanted from a deceased donor, after his mother Grace Bell -- who was born without a viable womb due to a condition called MRKH syndrome, which affects one in every 5,000 women -- underwent a 10-hour transplant operation at The Churchill Hospital in Oxford in June 2024.

Hugo was born just before Christmas 2025, weighing nearly 7lbs, at Queen Charlotte's and Chelsea Hospital in west London, following IVF treatment and embryo transfer at The Lister Fertility Clinic. Bell's transplant is one of three completed so far as part of a UK clinical research trial that plans to carry out 10 such procedures from deceased donors, and Hugo is the first baby born from any of them.
Earlier in 2025, a separate effort produced baby Amy, the first UK birth from a living womb donation -- her mother had received her older sister's womb in January 2023. Globally, more than 100 womb transplants have been performed, resulting in over 70 healthy births.
Earth

Climate Physicists Face the Ghosts in Their Machines: Clouds (quantamagazine.org) 25

Climate scientists trying to predict how much hotter the planet will get have long grappled with a surprisingly stubborn problem -- clouds, which both reflect sunlight and trap heat, account for more than half the variation between climate predictions and are the main reason warming projections for the next 50 years range from 2 to 6 degrees Celsius.

Two research groups are now racing to close that gap using AI, though they disagree sharply on method. Tapio Schneider at Caltech built CLIMA, a model that uses machine learning to optimize cloud parameters within traditional physics equations; it will be unveiled at a conference in Japan in March. Chris Bretherton at the Allen Institute for AI took a different path -- his ACE2 neural network, released in 2024, learns from 50 years of atmospheric data and largely bypasses physics equations altogether.
Science

Stressful People in Your Life Could Be Adding Months To Your Biological Age (pnas.org) 34

A study published last week in PNAS found that people who regularly cause problems or make life difficult -- whom the researchers call "hasslers" -- are associated with measurably faster biological aging in those around them, at a rate of roughly 1.5% per additional hassler and about nine months of additional biological age relative to same-age peers.

The research drew on DNA methylation-based epigenetic clocks and ego-centric network data from a state-representative probability sample of 2,345 adults in Indiana, aged 18 to 103. Nearly 29% of respondents reported at least one hassler in their close network. The biological toll varied by relationship type: hasslers who were family members showed the strongest and most consistent associations with accelerated aging, while spouse hasslers showed no significant effect on either epigenetic measure.

The damage also went beyond aging clocks -- each additional hassler was associated with greater depression and anxiety severity, higher BMI, increased inflammation, and higher multimorbidity. When benchmarked against smoking, a major behavioral risk factor for aging, the hassler effect corresponded to roughly 13 to 17% of smoking's estimated impact on the same aging clocks.
Space

Rule-Breaking Black Hole Growing At 13x the Cosmic 'Speed Limit' Challenges Theories (livescience.com) 20

"A surprisingly ravenous black hole from the dawn of the universe is breaking two big rules," reports Live Science. "It's not only exceeding the 'speed limit' of black hole growth but also generating extreme X-ray and radio wave emissions — two features that are not predicted to coexist..."

"How is this rule-breaking behavior even possible? In a paper published Jan. 21 in The Astrophysical Journal, an international team of researchers observed ID830 in multiple wavelengths to find an answer...." As they attract gas and dust, this material accumulates in a swirling accretion disk. Gravity pulls the material from the disk into the black hole, but the infalling material generates radiation pressure that pushes outward and prevents more stuff from falling in. As a result, black holes are muzzled by a self-regulating process called the Eddington limit... Its X-ray brightness suggests that ID830 is accreting mass at about 13 times the Eddington limit, due to a sudden burst of inflowing gas that may have occurred as ID830 shredded and engulfed a celestial body that wandered too close. "For a supermassive black hole (SMBH) as massive as ID830, this would require not a normal (main-sequence) star, but a more massive giant star or a huge gas cloud," study co-author Sakiko Obuchi, an observational astronomer at Waseda University in Tokyo, told Live Science via email. Such super-Eddington phases may be incredibly brief, as "this transitional phase is expected to last for roughly 300 years," Obuchi added.

ID830 also simultaneously displays radio and X-ray emissions. These two features are not expected to coexist, especially because super-Eddington accretion is thought to suppress such emissions. "This unexpected combination hints at physical mechanisms not yet fully captured by current models of extreme accretion and jet launching," the researchers said in a statement. So while ID830 is launching massive radio jets, its X-ray emissions appear to originate from a structure called a corona, produced as intense magnetic fields from the accretion disk create a thin but turbulent billion-degree cloud of turbocharged particles. These particles orbit the black hole at nearly the speed of light, in what NASA calls "one of the most extreme physical environments in the universe." Altogether, ID830's rule-breaking behaviors suggest that it is in a rare transitional phase of excessive consumption — and excretion. This incredible feeding burst has energized both its jets and its corona, making ID830 shine brightly across multiple wavelengths as it spews out excess radiation.

Additionally, based on UV-brightness analysis, quasars like ID830 may be unexpectedly common, the researchers said. Models predict that only around 10% of quasars have spectacular radio jets, but these energetic objects could be significantly more abundant in the early universe than previously suggested. Most importantly, ID830 also shows how SMBHs can regulate galaxy growth in the early universe. As a black hole gobbles matter at the super-Eddington limit, the energy from its resultant emissions can heat and disperse matter throughout the interstellar medium — the gas between stars — to suppress star formation. As a result, ancient SMBHs like ID830 may have grown massive at the expense of their host galaxies.

Crime

DNA Technology Convicts a 64-Year-Old for Murdering a Teenager in 1982 (cnn.com) 78

"More than four decades after a teenager was murdered in California, DNA found on a discarded cigarette has helped authorities catch her killer," reports CNN: Sarah Geer, 13, was last seen leaving her friend's houseï in Cloverdale, California, on the evening of May 23, 1982. The next morning, a firefighter walking home from work found her body, the Sonoma County District Attorney's Office said in a news release... Her death was ruled a homicide, but due to the "limited forensic science of the day," no suspect was identified and the case went cold for decades, prosecutors said.

Nearly 44 years after Sarah's murder, a jury found James Unick, 64, guilty of killing her on February 13. It would have been the victim's 57th birthday, the Sonoma County District Attorney's Office told CNN. Genetic genealogy, which combines DNA evidence and traditional genealogy, helped match Unick's DNA from a cigarette butt to DNA found on Sarah's clothing, according to prosecutors... [The Cloverdale Police Department] said it had been in communication with a private investigation firm in late 2019 and had partnered with them in hopes the firm could revisit the case's evidence "with the latest technological advancements in cold case work...."

"The FBI, with its access to familial genealogical databases, concluded that the source of the DNA evidence collected from Sarah belonged to one of four brothers, including James Unick," prosecutors said. Once investigators narrowed down the list of suspects to the four Unick brothers, the FBI "conducted surveillance of the defendant and collected a discarded cigarette that he had been smoking," prosecutors said. A DNA analysis of the cigarette confirmed James Unick's DNA matched the 2003 profile, along with other DNA samples collected from Sarah's clothing the day she was killed.

In a statement, the county's district attorney "While 44 years is too long to wait, justice has finally been served..."

And the article points out that "In 2018, genetic genealogy led to the arrest of the Golden State Killer, and it has recently helped solve several other cold cases, including a 1974 murder in Wisconsin and a 1988 murder in Washington."
Science

Researchers Discover Ancient Bacteria Strain That Resists 10 Modern Antibiotics (cnn.com) 16

CNN reports on a 13,000-year-old glacier in a Romanian cave, where scientists say a bacterial strain they thawed and analyzed "is resistant to 10 modern antibiotics used to treat diseases such as urinary tract infections and tuberculosis."

But there's no evidence the bacteria is harmful to humans, CNN notes, and "The scientists said the insights they have gained from the work may help in the fight against modern superbugs that can't be treated by commonly used antibiotics." Analysis of the Psychrobacter SC65A.3 genome revealed 11 genes that are potentially able to kill or stop the growth of other bacteria, fungi and viruses... Matthew Holland, a postdoctoral researcher in medicinal chemistry at the UK's University of Oxford, said that researchers were searching in new and extreme environments, such as ice caves and the seafloor, for biomolecules that could be developed into new antibiotic drugs. He was not involved in the new study. "The team in Romania found this particular bug had resistance to 10 reasonably advanced synthetic antibiotics and that in itself is interesting," he said. "But what they report as well is that it secreted molecules that were able to kill a variety of already resistant, harmful bacteria.

"So the hope is that can we look at the molecules it makes and see if there's the possibility within those molecules to make new antibiotics."

Medicine

Hazardous Substances Found In All Headphones Tested By ToxFREE Project (theguardian.com) 95

An anonymous reader quotes a report from the Guardian: You wear them at work, you wear them at play, you wear them to relax. You may even get sweaty in them at the gym. But an investigation into headphones has found every single pair tested contained substances hazardous to human health, including chemicals that can cause cancer, neurodevelopmental problems and the feminization of males. [...] Researchers say that while individual doses from particular sources may be low, a "cocktail effect" of daily, multi-source exposure nevertheless poses potentially severe long-term risks to health. [...]

Researchers bought 81 pairs of in-ear and over-ear headphones, either on the market in the Czech Republic, Slovakia, Hungary, Slovenia and Austria, or from the online marketplaces Shein and Temu, and took them for laboratory analysis, testing for a range of harmful chemicals. "Hazardous substances were detected in every product tested," they said. Bisphenol A (BPA) appeared in 98% of samples, and its substitute, bisphenol S (BPS), was found in more than three-quarters. Synthetic chemicals used to stiffen plastic, BPA and BPS mimic the action of oestrogen inside organisms, causing a range of adverse effects including the feminization of males, early onset puberty in girls, and cancer. Previous studies have shown that bisphenols can migrate from synthetic materials into sweat, and that they can be absorbed through the skin.

"Given the prolonged skin contact associated with headphone use, dermal exposure represents a relevant pathway, and it is reasonable to assume that similar migration of BPA and its substitutes may occur from headphone components directly to the user's skin," the researchers said. Also found in the headphones tested were phthalates, potent reproductive toxins that can impair fertility; chlorinated paraffins, which have been linked to liver and kidney damage; and brominated and organophosphate flame retardants, which have similar endocrine disrupting properties to bisphenols. Most were, however, found in only trace quantities.

Power

US Particle Accelerators Turn Nuclear Waste Into Electricity, Cut Radioactive Life By 99.7% (interestingengineering.com) 67

Researchers at the Thomas Jefferson National Accelerator Facility are advancing Accelerator-Driven Systems (ADS) that use high-energy proton beams to transmute long-lived nuclear waste into shorter-lived isotopes. "The process also generates significant heat, which can be harnessed to produce additional electricity for the grid," reports Interesting Engineering. The projects are supported by $8.17 million in grants from the Department of Energy's NEWTON (Nuclear Energy Waste Transmutation Optimized Now) program. From the report: The researchers are developing ADS technology. This system uses a particle accelerator to fire high-energy protons at a target (such as liquid mercury), triggering a process called "spallation." This releases a flood of neutrons that interact with unwanted, long-lived isotopes in nuclear waste. The technology can effectively "burn" the most hazardous components of the waste by transmuting these elements. While unprocessed fuel remains dangerous for approximately 100,000 years, partitioning and recycling via ADS can reduce that window to just 300 years. [...]

To make ADS economically viability, Jefferson Lab is tackling two primary technical hurdles: efficiency and power. Traditional particle accelerators require massive, expensive cryogenic cooling systems to reach superconducting temperatures. Jefferson Lab is pioneering a more cost-effective approach by coating the interior of pure niobium cavities with tin. These niobium-tin cavities can operate at higher temperatures, allowing for the use of standard commercial cooling units rather than custom, large-scale cryogenic plants. The team is also developing spoke cavities, which is a complex design intended to drive even higher efficiency in neutron spallation.

The second project focuses on the power source behind the beam. Researchers are adapting the magnetron -- the same component that powers microwave ovens -- to provide the 10 megawatts of power required for ADS. The primary challenge is that the energy frequency must match the accelerator cavity precisely at 805 Megahertz. In collaboration with Stellant Systems, researchers are prototyping advanced magnetrons that can be combined to reach the necessary high-power thresholds with maximum efficiency. The NEWTON program aims to enable the recycling of the entire US commercial nuclear fuel stockpile within the next 30 years.

Moon

NASA Eyes March 6 To Launch 4 Astronauts To the Moon On Artemis II Mission (npr.org) 23

An anonymous reader quotes a report from NPR: NASA could launch four astronauts on a mission to fly around the moon as soon as March 6th. That's the launch date (PDF) that the space agency is now working towards following a successful test fueling of its big, 322-foot-tall moon rocket, which is standing on a launch pad at the Kennedy Space Center in Florida.

"This is really getting real," says Lori Glaze, acting associate administrator of NASA's exploration systems development mission directorate. "It's time to get serious and start getting excited." But she cautioned that there's still some pending work that remains to be done out at the launch pad, and officials will have to conduct a multi-day flight readiness review late next week to make sure that every aspect of the mission is truly ready to go. "We need to successfully navigate all of those, but assuming that happens, it puts us in a very good position to target March 6th," she says, noting that the flight readiness review will be "extensive and detailed." [...]

When NASA workers first tested out fueling the rocket earlier this month, they encountered problems like a liquid hydrogen leak. Swapping out some seals and other work seems to have fixed these issues, according to officials who say that the latest countdown dress rehearsal went smoothly, despite glitches such as a loss of ground communications in the Launch Control Center that forced workers to temporarily use backups.

NASA

NASA Chief Classifies Starliner Flight As 'Type A' Mishap, Says Agency Made Mistakes (arstechnica.com) 44

NASA has officially classified Boeing Starliner's 2024 crewed flight as a "Type A" mishap, acknowledging serious technical failures and leadership shortcomings that nearly left astronauts unable to safely return. Administrator Jared Isaacman released (PDF) a 311-page internal report citing flawed decision-making and cultural issues, with the next Starliner flight now planned as uncrewed pending major fixes. Ars Technica reports: As part of the announcement, NASA Administrator Jared Isaacman sent an agency-wide letter that recognized the shortcomings of both Starliner's developer, Boeing, as well as the space agency itself. Starliner flew under the auspices of NASA's Commercial Crew Program, in which the agency procures astronaut transportation services to the International Space Station. "We are taking ownership of our shortcomings," Isaacman said.

"Starliner has design and engineering deficiencies that must be corrected, but the most troubling failure revealed by this investigation is not hardware," Isaacman wrote in his letter to the NASA workforce. "It is decision-making and leadership that, if left unchecked, could create a culture incompatible with human spaceflight." Isaacman said there would be "leadership accountability" as a result of the decisions surrounding the Starliner program, but did not say which actions would be taken.

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