TechCrunch reports: Jeff Bezos' space company Blue Origin is pausing its space tourism flights for "no less than two years" in order to focus all of its resources on upcoming missions to the moon, the company announced Friday. The decision puts a temporary halt on a program that Blue Origin has been using to fly humans past the Kármán line, the recognized boundary of space, for the last five years. Blue Origin made the announcement just a few weeks ahead of the expected third launch of its New Glenn mega-rocket, which is slated for late February...

The company said Friday that New Shepard has flown 38 times and carried 98 humans to space, along with more than 200 scientific and research payloads.
"The move is a clear sign that Blue Origin is going all in on its moon program as the company races with rival SpaceX," reports the Business Standard, "to be the first private company to land humans on the lunar surface for Nasa's Artemis program." Blue Origin holds a $3.4 billion contract with Nasa to develop its Blue Moon lander, designed to shuttle astronauts to and from the moon, with a landing originally targeted for 2029... The company is targeting the launch and landing of a cargo version of its lander as soon as this year, as a test ahead of eventually landing humans. Blue Origin has also presented an accelerated plan to Nasa for developing a lander that may be ready for carrying astronauts ahead of Starship, the large new rocket from Elon Musk's SpaceX.

Slashdot reader alternative_right writes: Quantum computers need extreme cold to work, but the very systems that keep them cold also create noise that can destroy fragile quantum information. Scientists in Sweden have now flipped that problem on its head by building a tiny quantum refrigerator that actually uses noise to drive cooling instead of fighting it. By carefully steering heat at unimaginably small scales, the device can act as a refrigerator, heat engine, or energy amplifier inside quantum circuits.

An anonymous reader quotes a report from Wired: About a decade ago, many media outlets -- including WIRED -- zeroed in on a weird trend at the intersection of mental health, drug science, and Silicon Valley biohacking: microdosing, or the practice of taking a small amount of a psychedelic drug seeking not full-blown hallucinatory revels but gentler, more stable effects. Typically using psilocybin mushrooms or LSD, the archetypal microdoser sought less melting walls and open-eye kaleidoscopic visuals than boosts in mood and energy, like a gentle spring breeze blowing through the mind. Anecdotal reports pitched microdosing as a kind of psychedelic Swiss Army knife, providing everything from increased focus to a spiked libido and (perhaps most promisingly) lowered reported levels of depression. It was a miracle for many. Others remained wary. Could 5 percent of a dose of acid really do all that?

A new, wide-ranging study by an Australian biopharma company suggests that microdosing's benefits may indeed be drastically overstated -- at least when it comes to addressing symptoms of clinical depression. A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Asberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression. The study has not yet been published. But MindBio's CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was "in front of the curve in microdosing research."

He called it "the most vigorous placebo controlled trial ever performed in microdosing." It found that patients dosed with a small amount of LSD (ranging from 4 to 20g, or micrograms, well below the threshold of a mind-blowing hallucinogenic dose) showed observable upticks in feelings of well-being, but worse MADRS scores, compared to patients given a placebo in the form of a caffeine pill. (Because patients in psychedelic trials typically expect some kind of mind-altering effect, studies are often blinded using so-called "active placebos," like caffeine or methylphenidate, which have their own observable psychoactive properties.) This means, essentially, that a medium-strength cup of coffee may prove more beneficial in treating major depressive disorder than a tiny dose of acid. Good news for habitual caffeine users, perhaps, but less so for researchers (and biopharma startups) counting on the efficacy of psychedelic microdosing. "It's probably a nail in the coffin of using microdosing to treat clinical depression," Hanka says. "It probably improves the way depressed people feel -- just not enough to be clinically significant or statistically meaningful."

Researchers at the University of New South Wales are developing a "reverse solar panel" that generates small amounts of electricity at night by harvesting infrared heat radiated from Earth. "In the past, scientists have demonstrated that a 'thermoradiative diode' can convert infrared radiation directly into electricity; when used to convert heat from Earth, they exploit the temperature difference between Earth and the night sky, generating a current directly from heat," notes ExtremeTech. "This approach completely eliminates the need for heat to generate steam, though the resulting capacity is fairly low." From the report: The researchers estimate they could generate only about a watt per square meter, which isn't much. One reason for the low output is that the Earth's atmosphere lessens the heat differential that drives the generative process; in space, though, that's not an issue.

Now, researchers believe that the ability to generate power in the moments between direct sunlight could help power satellites. That could be especially true in deep space, where periods without sunlight can be longer, and sunlight is often weaker; in these situations, losing electricity to heat loss is unacceptable.

Many satellites already use heat to generate electricity, though with a much more rarified "thermoelectric generator" that uses rare, expensive materials like plutonium to create heat. With thermoradiative diodes, the heat source can be the Sun-warmed body of the satellite itself.

A large Swedish study of 100,000 women found that using AI to assist radiologists reading mammograms reduced the rate of aggressive "interval" breast cancers by 12%. CBC News reports: For the study -- published in Thursday's issue of the medical journal The Lancet -- more than 100,000 women had mammography screenings. Half were supported by AI and the rest had their mammograms reviewed by two different radiologists, a standard practice in much of Europe known as double reading. It is not typically used in Canada, where usually one radiologist checks mammograms.

The study looked at the rates of interval cancer, the term doctors use for invasive tumors that appear between routine mammograms. They can be harder to detect and studies have shown that they are more likely to be aggressive with a poorer prognosis. The rate of interval cancers decreased by 12 percent in the groups where the AI screening was implemented, the study showed. [...] Throughout the two-year study, the mammograms that were supported by AI were triaged into two different groups. Those that were determined to be low risk needed only one radiologist to examine them, while those that were considered high risk required two. The researchers reported that numerically, the AI-supported screening resulted in 11 fewer interval cancers than standard screening (82 versus 93, or 12 per cent).

"This is really a way to improve an overall screening test," [said lead author, Dr. Kristina Lang]. She acknowledged that while the study found a decrease in interval cancer, longer-term studies are needed to find out how AI-supported screening might impact mortality rates. The screenings for the study all took place at one centre in Sweden, which the researchers acknowledged is a limitation. Another is that the race and ethnicity of the participants were not recorded. The next step, Lang said, will be for Swedish researchers to determine cost-effectiveness.

The preprint repository arXiv will require all submissions to be written in English or accompanied by a full English translation starting February 11, a policy change that explicitly permits the use of AI translators even as research suggests large language models remain inconsistent at the task.

Until now, authors only needed to submit an abstract in English. ArXiv hosts nearly 3 million preprints and receives more than 20,000 submissions monthly, though just 1% are in languages other than English.

Ralph Wijers, chair of arXiv's editorial advisory council, advises authors to verify any AI-generated translations. "Our own experience is that AI translation is good but not good enough," he says. A 2025 study from ByteDance Seed and Peking University ranked 20 LLMs on translation quality between Chinese and English; GPT-5-high scored nearly 77, just below the human expert benchmark of 80, but most models including GPT-4o, Claude 4, and Deepseek-V3 scored under 60.

Scientific American's Elizabeth Anne Brown recently "polled the great art houses of Europe" about whether they'd had any recent experiences with mold in their collections. Despite the stigma that keeps many institutions silent, she found that extremophile "xerophilic" molds are quietly spreading through museums and archives, thriving in low-humidity, tightly sealed storage and damaging everything from textiles and wood to manuscripts and stone. An anonymous Slashdot reader shares an excerpt from the article: Mold is a perennial scourge in museums that can disfigure and destroy art and artifacts. [...] Consequently, mold is spoken of in whispers in the museum world. Curators fear that even rumors of an infestation can hurt their institution's funding and blacklist them from traveling exhibitions. When an infestation does occur, it's generally kept secret. The contract conservation teams that museums hire to remediate invasive mold often must vow confidentiality before they're even allowed to see the damage.

But a handful of researchers, from in-house conservators to university mycologists, are beginning to compare notes about the fungal infestations they've tackled in museum storage depots, monastery archives, crypts and cathedrals. A disquieting revelation has emerged from these discussions: there's a class of molds that flourish in low humidity, long believed to be a sanctuary from decay. By trying so hard to protect artifacts, we've accidentally created the "perfect conditions for [these molds] to grow," says Flavia Pinzari, a mycologist at the Council of National Research of Italy. "All the rules for conservation never considered these species."

These molds -- called xerophiles -- can survive in dry, hostile environments such as volcano calderas and scorching deserts, and to the chagrin of curators across the world, they seem to have developed a taste for cultural heritage. They devour the organic material that abounds in museums -- from fabric canvases and wood furniture to tapestries. They can also eke out a living on marble statues and stained-glass windows by eating micronutrients in the dust that accumulates on their surfaces. And global warming seems to be helping them spread. Most frustrating for curators, these xerophilic molds are undetectable by conventional means. But now, armed with new methods, several research teams are solving art history cold cases and explaining mysterious new infestations...

The xerophiles' body count is rising: bruiselike stains on Leonardo da Vinci's most famous self-portrait, housed in Turin. Brown blotches on the walls of King Tut's burial chamber in Luxor. Pockmarks on the face of a saint in an 11th-century fresco in Kyiv. It's not enough to find and identify the mold. Investigators are racing to determine the limits of xerophilic life and figure out which pieces of our cultural heritage are at the highest risk of infestation before the ravenous microbes set in.

For decades, researchers have noted that cancer and Alzheimer's disease are rarely found in the same person, fuelling speculation that one condition might offer some degree of protection from the other. Nature: Now, a study in mice provides a possible molecular solution to the medical mystery: a protein produced by cancer cells seems to infiltrate the brain, where it helps to break apart clumps of misfolded proteins that are often associated with Alzheimer's disease. The study, which was 15 years in the making, was published on 22 January in Cell and could help researchers to design drugs to treat Alzheimer's disease.

"They have a piece of the puzzle," says Donald Weaver, a neurologist and chemist at the Krembil Research Institute at the University of Toronto in Canada, who was not involved in the study. "It's not the full picture by any stretch of the imagination. But it's an interesting piece." [...] A 2020 meta-analysis of data from more than 9.6 million people found that cancer diagnosis was associated with an 11% decreased incidence of Alzheimer's disease. It has been a difficult relationship to unpick: researchers must control for a variety of external factors. For example, people might die of cancer before they are old enough to develop symptoms of Alzheimer's disease, and some cancer treatments can cause cognitive difficulties, which could obscure an Alzheimer's diagnosis.

Early hominins in Europe were creating tools from raw materials hundreds of thousands of years before Homo sapiens arrived there, two new studies indicate, pushing back the established time for such activity. From a report: The evidence includes a 500,000-year-old hammer made of elephant or mammoth bone, excavated in southern England, and 430,000-year-old wooden tools found in southern Greece -- the earliest wooden tools on record.

The findings suggest that early humans possessed sophisticated technological skills, the researchers said. Katerina Harvati, a paleoanthropologist at the University of Tubingen in Germany and a lead author of the wooden-tool paper, which was published on Monday in the journal PNAS, said the discoveries provided insight into the prehistoric origins of human intelligence. Silvia Bello, a paleoanthropologist at London's Natural History Museum and an author on the elephant-bone study, which was published last week in Science Advances, concurred.

The artifacts in both studies, recovered from coal-mine sites, were probably produced by early Neanderthals or a preceding species, Homo heidelbergensis. Homo sapiens emerged in Africa more than 300,000 years ago, and the oldest evidence of them in Europe is a 210,000-year-old fossil unearthed in Greece. By the time Homo sapiens established themselves in Britain 40,000 years ago, other hominins had already lived there for nearly a million years.

An anonymous reader quotes a report from Universe Today: There's a bright side to every situation. In 2032, the Moon itself might have a particularly bright side if it is blasted by a 60-meter-wide asteroid. The chances of such an event are still relatively small (only around 4%), but non-negligible. And scientists are starting to prepare both for the bad (massive risks to satellites and huge meteors raining down on a large portion of the planet) and the good (a once in a lifetime chance to study the geology, seismology, and chemical makeup of our nearest neighbor). A new paper from Yifan He of Tsinghua University and co-authors, released in pre-print form on arXiv, looks at the bright side of all of the potential interesting science we can do if a collision does, indeed, happen. If Asteroid 2024 YR4 were to hit the Moon, researchers would be able to watch a large lunar impact unfold in real time and collect data on extreme collisions that usually exist only in computer models. Telescopes could follow how a newly formed crater and its pool of molten rock cool and solidify, while the resulting moonquake would offer a clearer picture of its internal structure via the seismic waves it sends through the Moon.

Furthermore, researchers could compare the fresh crater to older ones to improve our understanding of the Moon's long history of impacts. Debris blasted off the surface could even deliver small lunar samples to Earth.

Altogether, it would be a once-in-a-generation chance to learn more about how the Moon/rocky worlds respond to powerful impacts.

alternative_right shares a report from Phys.org: New findings from NASA's Perseverance rover have revealed evidence of wave-formed beaches and rocks altered by subsurface water in a Martian crater that once held a vast lake -- considerably expanding the timeline for potential habitability at this ancient site. In an international study led by Imperial College London, researchers uncovered that the so-called 'Margin unit' in Mars's Jezero crater preserves evidence of extensive underground interactions between rock and water, as well as the first definitive traces of an ancient shoreline.

These are compelling indicators that habitable, surface water conditions persisted in the crater (home to a large lake around 3.5 billion years ago) further back in time than previously thought. "Shorelines are habitable environments on Earth, and the carbonate minerals that form here can naturally seal in and preserve information about the ancient environment," said lead author Alex Jones, a Ph.D. researcher in the Department of Earth Science and Engineering (ESE) at Imperial. The findings have been published in the Journal of Geophysical Research: Planets.

An anonymous reader quotes a report from Science.org: Some 10,109 doctoral-trained experts in science and related fields left their jobs last year as President Donald Trump dramatically shrank the overall federal workforce. That exodus was only 3% of the 335,192 federal workers who exited last year but represents 14% of the total number of Ph.D.s in science, technology, engineering, and math (STEM) or health fields employed at the end of 2024 as then-President Joe Biden prepared to leave office. The numbers come from employment data posted earlier this month by the White House Office of Personnel Management (OPM). At 14 research agencies Science examined in detail, departures outnumbered new hires last year by a ratio of 11 to one, resulting in a net loss of 4224 STEM Ph.D.s. The graphs that follow show the impact is particularly striking at such scientist-rich agencies as the National Science Foundation (NSF). But across the government, these departing Ph.D.s took with them a wealth of subject matter expertise and knowledge about how the agencies operate.

[...] Science's analysis found that reductions in force, or RIFs, accounted for relatively few departures in 2025. Only at the Centers for Disease Control and Prevention, where 16% of the 519 STEM Ph.D.s who left last year got pink RIF slips, did the percentage exceed 6%, and some agencies reported no STEM Ph.D. RIFs in 2025. At most agencies, the most common reasons for departures were retirements and quitting. Although OPM classifies many of these as voluntary, outside forces including the fear of being fired, the lure of buyout offers, or a profound disagreement with Trump policies, likely influenced many decisions to leave. Many Ph.D.s departed because their position was terminated.

Scientists have released DinoTracker, a free AI-powered app that identifies dinosaur footprints by analyzing shape patterns rather than relying on potentially flawed historical labels. "When we find a dinosaur footprint, we try to do the Cinderella thing and find the foot that matches the slipper," said Prof Steve Brusatte, a co-author of the work. "But it's not so simple, because the shape of a dinosaur footprint depends not only on the shape of the dinosaur's foot but also the type of sand or mud it was walking through, and the motion of its foot." The Guardian reports: [...] Brusatte, [Dr Gregor Hartmann, the first author of the new research from Helmholtz-Zentrum in Germany] and colleagues fed their AI system with 2,000 unlabelled footprint silhouettes. The system then determined how similar or different the imprints were from each other by analysing a range of features it identified as meaningful. The researchers discovered these eight features reflected variations in the imprints' shapes, such as the spread of the toes, amount of ground contact and heel position. The team have turned the system into a free app called DinoTracker that allows users to upload the silhouette of a footprint, explore the seven other footprints most similar to it and manipulate the footprint to see how varying the eight features can affect which other footprints are deemed most similar. Hartmann said that at present experts had to double check if factors such as the material the footprints were made in, and their age, matched the scientific hypothesis, but the system clustered prints with those expected from classifications made by human experts about 90% of the time. The findings have been published in the journal PNAS.

OpenAI has launched Prism, a free scientific research app that aims to do for scientific writing what coding agents did for programming. Engadget reports: Prism builds on Crixet, a cloud-based LaTeX platform the company is announcing it acquired today. For the uninitiated, LaTeX is a typesetting system for formatting scientific documents and journals. Nearly the entire scientific community relies on LaTeX, but it can make some tasks, such as drawing diagrams through TikZ commands, time-consuming to do. Beyond that, LaTeX is just one of the software tools a scientist might turn to when preparing to publish their research.

That's where Prism comes into the picture. Like Crixet before it, the app offers robust LaTeX editing and a built-in AI assistant. Where previously it was Crixet's own Chirp agent, now it's GPT-5.2 Thinking. OpenAI's model can help with more than just formatting journals -- in a press demo, an OpenAI employee used it to find and incorporate scientific literature that was relevant to the paper they were working on, with GPT-5.2 automating the process of writing the bibliography. [...] Later in the same demo, the OpenAI employee used Prism to generate a lesson plan for a graduate course on general relativity, as well as a set of problems for students to solve. OpenAI envisions these features helping scientists and professors spend less time on the more tedious tasks in their professions.

The Bulletin of the Atomic Scientists on Tuesday set their symbolic Doomsday Clock to 85 seconds before midnight -- the closest the timepiece has ever been to the theoretical point of annihilation since scientists created it during the Cold War in 1947.

The clock now stands four seconds nearer than last year's setting, and this marks the third time in four years that the Bulletin has moved it closer to midnight. The Chicago-based nonprofit pointed to aggressive behavior by nuclear powers Russia, China and the United States, fraying nuclear arms control frameworks, ongoing conflicts in Ukraine and the Middle East, unregulated AI integration into military systems, and climate change.

"In terms of nuclear risks, nothing in 2025 trended in the right direction," said Alexandra Bell, the Bulletin's president and CEO. The last remaining nuclear arms pact between the US and Russia, the New START treaty, expires on February 5.