SpaceX has agreed to acquire Cursor for $60 billion in stock, adding the popular AI coding assistant to Elon Musk's newly public aerospace-and-AI conglomerate. CNBC reports: Cursor built a popular AI coding tool that helps software developers generate, edit and review code, and the company has experienced explosive growth since its founding in 2022. In November, Cursor said it crossed $1 billion in annualized revenue, according to a release at the time. Cursor was also ranked at No. 37 on the annual CNBC Disruptor 50 list in 2026.

[...] Musk merged SpaceX with his AI startup, xAI, earlier this year, and the Cursor deal looks set to help revitalize the company's efforts to compete with rivals like Anthropic and OpenAI, which also offer popular coding tools. SpaceX expects the merger to close during the third quarter of this year, according to a filing with the Securities and Exchange Commission. The transaction is subject to "requisite regulatory approvals," the filing said.

New simulations suggest Venus' extremely slow backward rotation may have been triggered by a high-angle collision with a fast-moving object roughly one-tenth its mass. The impact could have dramatically altered Venus' spin and melted nearly its entire mantle. Universe Today reports: Venus' bizarre and extraordinarily slow retrograde rotation on its axis has long puzzled planetary scientists. But in a new paper presented at the recent European Geosciences Union General Assembly in Vienna, the authors argue that their models indicate that a high angle moon-sized, high-velocity impactor likely triggered Venus's strange 248-day rotation. And it probably happened within the first 50 million years of Venus' formation. [...] The team found that an impactor that is about a tenth of Venus' mass hitting the planet at a high angle could drastically slow the early young planet's rotation.

Depending on the actual impact parameters, we can slow down a rapidly rotating early Venus to rotation rates that are that are compatible with long-term evolution towards a slow rotating planet, says [Cedric Gillmann, the paper's lead author and a planetary scientist at ETH Zurich]. Or even in some cases with large energetic impact that happen with a tangential impact that would even put planets early on in already a retrograde but faster rotation, he says. In the simulations, giant impacts expectedly produce surface magma oceans, the paper's authors note. Their relative depths vary depending on impact properties: from a shallow melt layer in the order of 100km thick to a fully molten mantle, they note. If the surface can radiate heat to space efficiently, the magma ocean cools down quickly, they write.

If Gillmann and colleagues are correct, Venus' likely impactor also melted some 99 percent of Venus' mantle. That is, the interior structure that extends between its core and crust. You will get rid of that impact heat pretty efficiently, and after a few hundred million years, you end up seeing an evolution that is very difficult to distinguish from a case where you don't have an impact, says Gillmann. What role the impact may have played in Venus' lack of plate tectonics, however, remains open for debate. But it's known that Venus' lack of a large-scale carbon recycling mechanism likely led to its current runaway greenhouse.

A Chinese Zhuque-2E rocket's upper stage broke apart shortly after last week's June 9 launch, likely creating 100 to 150 pieces of debris in a busy region of low-Earth orbit crossed by the ISS and lower-altitude Starlink satellites. Most fragments should reenter within months because of atmospheric drag, but experts say the incident adds to a worsening trend as China leaves more large rocket bodies in orbit while expanding its launch rate. Ars Technica reports: The US Space Force confirmed the breakup event in a post on space-track.org, a website used by the military to distribute orbit data to the public. "The tracked pieces are being incorporated into routine conjunction assessment to support spaceflight safety," the Space Force wrote in an advisory. "There are currently no threats to human spaceflight. Analysis is ongoing." So far, the Space Force has not added any of the debris fragments to the official catalog of human-made space objects.

[...] The bad news is that the Zhuque-2E's breakup is the latest chapter in China's growing contribution to the space junk problem. After decades of leaving spent rocket bodies in orbit, launch operators in most countries now reserve enough fuel to steer their upper stages back to Earth for controlled reentries. Rocket bodies attributed to Russia and the former Soviet Union account for the bulk of the launch-related debris in long-lived orbits, followed by China and the United States. But the Russian and American numbers are declining or holding steady, while the mass of Chinese rocket bodies in these long-lived orbits has grown by more than 150 percent in the past five years, according to a new analysis by Space Domain Awareness expert Jim Shell. The increase comes as China ramps up launches of its own megaconstellations designed to compete with SpaceX's Starlink.

Rocket bodies are the most concerning sources of space debris because they are typically fairly large in size and mass, often with residual propellant and high-pressure gases that can trigger an explosion. There is no way to maneuver or dispose of them if left abandoned in orbit after releasing their payloads. McKnight characterized the recent breakup of the Zhuque-2E rocket as a "slight space safety issue," but the trend is not good. China's Long March 6A rocket has an especially bad track record, including two explosions that littered a higher-altitude low-Earth orbit with more than 1,000 debris fragments, where they will remain for decades or centuries. "Three of the top four breakup events in LEO are of Chinese origin, with two of these events being from Chinese (rocket body) explosions in the last four years," McKnight said.

An anonymous reader quotes a report from Bloomberg: While traditional hotspots in the region such as Thailand, South Korea and Malaysia focus on services such as cosmetic surgery, IVF or physicals, China is trying to differentiate itself by providing some of the world's most advanced procedures. "There are two reasons why a patient travels for medical treatments: availability of advanced treatments and price," said Victor Cao, operations director of Joyful Medical, an agency in Shanghai that connects international patients to advanced cancer therapies in China. "Chinese people used to travel overseas for treatments that were not available at home, but now tables have turned."

As expanding visa-free policies eased travel in the past year or so, videos are proliferating on social media of foreigners recounting their positive experiences of treatment in China, usually for consumer procedures like acupuncture and tooth scaling. But one treatment that's more quietly gaining traction is CAR-T, among the most promising breakthroughs in oncology but unavailable in most countries, or extremely costly. The process sees doctors collect T cells from the patient's blood then modify them in a lab to produce a special receptor, CAR, that can bind to a specific protein on cancer cells. These engineered cells are then multiplied into large numbers and infused back into the patient. The CAR-T cells seek out cancer cells carrying the target antigen and kill them. In the US, one single infusion can cost between $300,000 to $475,000, according to the American Cancer Society. In China, the equivalent costs about $150,000 to $180,000, and it could get even cheaper -- its drug regulator recently accepted a marketing application for a therapy aimed to be priced below 300,000 yuan ($44,000).

China's medical tourism market remains in its infancy. Lecheng International Medical Tourism Pilot Zone in Hainan, which was designated as the country's only special medical zone in 2013, treated just a few thousand foreign medical tourists last year, compared to hundreds of thousands of domestic patients who visited. There, patients can access advanced drugs, devices, and therapies approved in other countries but not elsewhere in mainland China. But China is pushing to upgrade its economy and reshape its global image from just a manufacturing hub into a provider of high-value services, and demand for medical tourism is surging. Globally, the market is estimated at around $34 billion and expected to reach $126 billion by 2035, according to San Francisco-based Grand View Research. Meanwhile, China's sector is projected to grow from $1.3 billion in 2025 to $3.4 billion by 2035, according to New York-based firm Market Research Future. "The patients chose China for something they can't get at home," said Shi Haoying, the group's founder and chief executive officer. "I think the growing attention to medical tourism to China is the inevitable result of long-term accumulation and development in many areas, such as growing medical technologies, quality of service and cost-effectiveness."

Jeroen Groenewegen-Lau, an analyst at the Mercator Institute for China Studies, added: "Many new treatments, including in very advanced areas, are made in China but too advanced for the state of its healthcare system and the ability of its patients to pay for these things. It's in China's interest to integrate into the international system."

Two recent studies argue that smartphones may have contributed to falling birthrates by reducing in-person social interaction, sexual frequency, and other conditions tied to unintended pregnancies. "One of the studies published in May is called 'The Collapse of Teen Fertility in the Digital Era' and the other, published just Monday, is titled 'Is the iPhone Birth Control? Causal Evidence from AT&T's 2007-2011 Carrier Monopoly,'" reports KTLA. "Both were chronicled in a New York Times piece by political writer Sabrina Tavernise on Monday." Slashdot reader sabbede submitted the story. From the report: The one from May, authored by two University of Cincinnati professors, posits that teen fertility "collapsed globally" starting around 2007 -- the same year the first iPhone was released. "Smart phones changed how teens spend time with each other ... this change in turn drove the collapse in teen fertility," the study's abstract reads. "Once enough teens are on the phone, being on the phone is where the peer network is; in-person time falls sharply, and with it the unstructured contact in which most unintended teen conceptions occur." The study claimed that countries "across the income and policy spectrum" were affected by the teen fertility drop, and that researchers used data from multiple countries, including the U.S., England and Wales, to rule out "country-specific contraceptive access and welfare reform stories." "This model predicts that the shift towards the phone-mediated equilibrium affects multiple aspects of teen behavior," the abstract continues, concluding that "the same instrument that produces a collapse in teen fertility produces a surge in teen suicides."

The study published on Monday looks more closely at the United States, explaining that nationwide general fertility rates have fallen 22% since 2007. "[This is] a sustained decline not readily explained by economic conditions, contraceptive use, housing or childcare costs, or other commonly cited factors," the National Bureau of Economic Researchers study states. "We assess the potential role of a different shock: the diffusion of the smartphone." As mentioned before, the first iPhone was rolled out in 2007, and this study makes use of that timeframe as "a natural experiment" by using data from 2007 through 2011, when iPhones were only sold on AT&T. "From June 2007 through February 2011, the device was sold only on AT&T, allowing us to identify its effect from variation in AT&T's mobile broadband coverage," the study says. "Entropy-balanced Poisson and synthetic difference-in-differences event studies imply that access to the iPhone reduced births by 4.5-8.0% at ages 15-19 and 3.2-6.6% at ages 20-24, with statistically significant but smaller declines among older cohorts. Placebo analyses applied to Verizon and Sprint's pre-2011 coverage footprint are null.

Taken together, these cohort effects imply that the diffusion of the iPhone deepened the decline in births among women under 30 while suppressing the rise in births among older women." "Overall, the diffusion of the iPhone explains 33-52% of the decline in the general fertility rate among women aged 15-44," researchers continued. "National-survey evidence on time use and sexual behavior is consistent with the iPhone reducing in-person interactions, increasing pornography use and reducing sexual frequency."

fjo3 shares a report from The Guardian: Tests reveal that when people are ambling about, they have a natural tendency to turn to the left and walk in an anticlockwise direction. "If you simply ask someone to start walking, whether they are wandering around a museum, a supermarket, or even an empty room, it is surprisingly likely that they will drift counterclockwise," said Dr Inaki Echeverria Huarte at University of Navarra in Spain.

As with many critical discoveries in science, the revelation owes a debt to serendipity. During the pandemic, the researchers ran experiments to see how many people could share a space while keeping a safe distance. On reviewing the video, they noticed that crowds overwhelmingly walked in an anticlockwise direction. The surprise set in motion an entire research project. The scientists conducted a series of experiments in which individual pedestrians or small crowds roamed around enclosed spaces. Time and again, the researchers observed the tendency to walk in an anticlockwise direction.

Suspecting that cultural norms might play a role, the team joined forces with Dr Claudio Feliciani at the University of Tokyo. He found the same results in Japan. The finding held when the researchers accounted for people being right-handed, right-footed and right-eye dominant, and was seen in both male and female walkers. The only difference they spotted was a more pronounced bias in children. "Each of us carries a small personal bias to turn slightly to one side, and when many people share a space, those tiny biases add up into a net counterclockwise rotation," said Echeverria Huarte. Researchers think the tendency may be tied to biomechanics: people are not perfectly symmetrical, and the way the brain processes sensory information and coordinates muscles may gently tip walkers toward one side. Right-side dominance may also play a role, especially in running, where anticlockwise movement puts more internal force on the right side of the body and may feel more natural to right-leg-dominant athletes.

"We have tested several ideas and the bias stubbornly keeps showing up, so the exact mechanism is still an open question," said Echeverria Huarte.

The findings have been published in Nature Communications.

Commonwealth Fusion has published five peer-reviewed papers laying out the physics case for ARC, its planned 400 MW fusion power plant, which would follow the company's smaller SPARC tokamak now under construction. The papers suggest ARC could produce more energy than it consumes using high-temperature superconducting magnets, molten-salt heat extraction, and 15-minute fusion pulses. Ars Technica reports: ARC will be a tokamak that hosts fusion between hydrogen's two heavier isotopes, deuterium and tritium. This reaction results in a helium nucleus and releases a neutron and radiation. The helium transfers heat to the plasma, maintaining the conditions needed for fusion, but it is otherwise a waste product, referred to as "ash" in the fusion context. The neutron and radiation, however, are put to use. Part of that use is simply imparting energy into a blanket of molten salt that surrounds the fusion chamber. That energy, in the form of heat, will be used to drive a turbine that produces the electricity. The molten salt includes lithium ions; when one lithium isotope absorbs a neutron, it decays into more helium, plus tritium that can be used as fuel for the reactor. There are isotopes present that will also release additional neutrons, allowing this process to generate sufficient fuel.

Overall, the present design of ARC is expected to produce about 1.13 GW of fusion power, with 500 MW of that extracted as electricity. Some of that (100 MW) will be needed to power the plant's operations, leaving 400 MW to be sent to the grid. The rest of the energy is either kept in the tokamak to maintain the fusion reactions or lost due to inefficiencies in the heat and energy transfer of the system. There's a lot of uncertainty about these numbers; the 1.13 GW is just the center of a range of potential values running from 900 MW to 1.3 GW, so the 400 MW output may need to be adjusted up or down accordingly.

Some of that 400 MW comes during periods where fusion is not occurring. The nuclear reactions will occur within 15-minute-long periods that will be interspersed with one minute resets. The resets are meant to be kept short enough that nothing has much of a chance to cool down before it gets heated up again -- thermal inertia will let it continue generating power. That will be one of the key differentiators with SPARC, which doesn't have the heat extraction needed to maintain stable fusion for these long time periods, and so can't maintain the near constant temperatures needed for reliable power generation.

It's inevitable that parts of the device will be exposed to radiation and perhaps fusion plasma. The inner walls of the reactor will be shielded by tungsten, which will limit erosion by the conditions. Meanwhile, the vacuum vessel is designed to be replaced every one to two years. The papers note that this flexibility will allow them to make some design changes even after ARC is built. To enable this, the whole tokamak is meant to split in half for maintenance.

NASA has named Randy Bresnik, Luca Parmitano, Frank Rubio, and Andre Douglas as the crew for Artemis III, which has been reworked from a moon-landing mission into a roughly two-week Earth-orbit test of lunar landers being built by SpaceX and Blue Origin. NBC News reports: Randy Bresnik, Luca Parmitano, Frank Rubio and Andre Douglas are expected to launch into Earth orbit next year, with the goal of testing two commercially developed lunar landers that are slated to carry astronauts to the surface of the moon during the Artemis IV mission in 2028. Bresnik will be the mission's commander, with Parmitano, an Italian astronaut with the European Space Agency, serving as the pilot. Douglas and Rubio will be mission specialists, and Bob Hines will train with the crew as a backup member. "This test flight will enable us to prove we can carry out highly choreographed operations with our partners across hardware interfaces, software propulsion systems and life support elements with crew in the high-stakes space environment," Jeremy Parsons, NASA's Artemis program manager, said during NASA's announcement on Tuesday.

Bresnik has been to the International Space Station twice, most recently as commander of an expedition in 2017. A retired U.S. Marine colonel, he was selected as a NASA astronaut in 2004. Bresnik has helped oversee development and testing of spacecraft for the Artemis program as an assistant to the chief of the Astronaut Office, which manages astronaut training and operations. Parmitano has also done two stints on the ISS and served as commander of an expedition in 2019. He has completed a total of six spacewalks and also performed the first live DJ set in orbit. Before becoming an astronaut, Parmitano was a test pilot for the Italian air force.

For Rubio, a physician with 28 years of service in the Army, Artemis III will be his second trip to space. From 2022 to 2023, he spent 371 days on the space station, breaking the record for longest-duration spaceflight by an American, according to NASA. Douglas is the only crew member making his spaceflight debut. An engineer who previously worked on space exploration and robotics at Johns Hopkins University Applied Physics Lab, he became a NASA astronaut in 2022. Douglas was the backup crew member for the Artemis II mission around the moon earlier this year. He told NBC News in an interview after Tuesday's announcement that the role had at times been a challenge. "It was hard to figure out how do you balance getting ready to go, not go, all that stuff," he said. "But to go now is just fantastic."

Researchers say mysterious, seconds-long GPS interference bursts detected across Europe appear to come from Russian EKS early-warning satellites, making this "a rare example of human-made GPS interference coming from space," reports Ars Technica. The signals may be tests of space-based jamming capability, short satellite communications, or something else, but experts say they raise troubling questions about whether GPS disruption could eventually be weaponized on a continental scale. From the report: The discovery came from an investigation detailed in a June 2 preprint paper by Todd Humphreys and his student Zach Clements at The University of Texas at Austin, along with Argyris Krizise at Stanford University in California. By sifting through public data from ground-based stations with global navigation satellite system (GNSS) receivers, they identified a pattern of high-powered interference lasting less than 10 seconds each time but simultaneously detectable by ground stations across Europe from Norway to Spain to Poland, and even reaching as far west as Greenland and Canada.

By analyzing the ground station data from January 2019 to April 2026, the researchers found 75 days with at least one widespread GNSS interference event overlapping with the GPS L1 frequency band centered on 1575.42 megahertz. That represents the main band used for signal transmission by the US-made GPS satellite constellation and GNSS constellations from other countries. Such interference patterns happened mostly on Tuesdays, Wednesdays, and Thursdays during business hours in Europe, Humphreys told the YouTube channel Veritasium. Because such "continental-scale" interference was simultaneously affecting GPS receivers across Europe and beyond, Humphreys and his colleagues calculated that the source had to be at least 1,200 kilometers above the Earth.

[...] In the Veritasium video, Humphreys speculated that the Russians may have been testing the satellites' GPS interference capabilities only briefly on a neighboring frequency adjacent to the typical GPS band. "And then in the eventual future when there is a hot conflict, they go ahead and tune their transmitter down to the GPS band, but it's much more damaging now that it lies right on that band," he said. Incidentally, the raw data also revealed a second interference burst from the Russian satellites in a lower-frequency band used by China's BeiDou navigation system. "I can no longer say this is accidental with confidence," Humphreys told Veritasium. He also described the Russian satellites' quiet demonstration as a "massive escalation in the electronic warfare background conflict that is going on right now." Richard Bowden, division head of assured and resilient PNT at the multinational technology company GMV in Spain, wrote in a LinkedIn comment: "These signals are, without a doubt, intentional and placed on or around GNSS signals, and have the potential to disrupt legitimate use of GNSS services. But from our side at least, we can't be sure they are intentionally malicious or intended as an EW [electronic warfare] weapon."

Jeff Bezos is backing Flourish, a new "neuro AI" startup with $500 million in funding and a reported $2.5 billion valuation, that aims to reinvent AI by studying the brain's architecture and building systems that learn continuously while using far less power than today's large language models. The company's long-term bet is that neuroscientists and AI researchers working together can uncover the brain's "core algorithm" and eventually create brain-inspired AI that runs on a tiny fraction of current compute. Wired reports: Rob Williams knows how to pitch Jeff Bezos: You write a press release as if your product has already been built. Bezos reads it and gives a thumbs up or down. Williams went through this process a lot as an executive on Amazon's "S-team," in charge of software products such as Alexa, until his departure last fall. But the pitch he made a few weeks later -- in December 2025 -- was different. Now he was collaborating with Thomas Reardon, a neuroscientist and repeat startup founder, and approaching Bezos as a funder, not a boss. Here's what Bezos, sitting on his yacht somewhere, read while Williams anxiously watched on Zoom: "Flourish is a neuro AI company that is solving the two most difficult problems facing AI today: power efficiency and continuous learning. We are building Cortex AI, the first synthetic intelligence system designed to match the computational capacity, learning efficiency, and power budget of the human brain."

A month later, I'm lunching with Reardon and Williams in the Flatiron neighborhood in New York City. Reardon gets right to the point. AI has dug itself into a hole, he says. Though increasingly powerful, large language models are greedy consumers of computer power and data. Though the inspiration for LLMs was rooted in biology, current frontier models have little in common with the human brain. A person uses about 20 watts of energy to process information; a single chip in an AI training cluster uses more than 30 times that amount. The hyperscalers require thousands of chips and gigawatts of energy, enough to power small cities. And those models need to suck up virtually all of what humans have written. Each new model requires more, more, more. For all of that, the models don't learn. Once you train them, they're stuck. The goal, Reardon tells me, is to build "a synthetic artificial intelligence brain that runs on 50 watts or less." It should adapt to its conditions, be as nimble as a human mind, and burn a tiny fraction of an LLM's compute power and energy. The proof of concept is thriving inside our skulls. "There's something fundamentally wrong with saying, "I need to basically read every book ever written 20 times over in order to learn English,'" Reardon says. "A human baby does it with a couple hundred thousand utterances."

Reardon and Williams haven't figured out yet how to build systems that match the magic of a human brain. What they have is a belief that an expert, well-resourced team -- of AI researchers and neuroscientists working essentially side by side -- can find the answer. The neuroscientists will conduct original wet lab experiments with some of the most advanced lab equipment available, to hunt for usable intel on the brain's architecture. They plan to release the models they're currently developing as near-term products on the path to a full reinvention of AI. The fuzziness of the proposal didn't bother Jeff Bezos. After reading Williams' two-pager, he chipped in $50 million. Other funding came from Lux Capital, Google Ventures, and Catalio, among others. Bezos then almost doubled his initial stake and told Reardon he'd have given more if they'd asked. Now with a war chest of $500 million and a reported valuation of $2.5 billion, Flourish just needs to invent a new way to do AI.

Italian fashion house Prada "unveiled on Sunday the inner-layer garment set to be worn by NASA astronauts heading to the moon," reports Reuters.

"The body-hugging suit, created in collaboration with Houston-based space infrastructure developer Axiom Space, features ventilation tubes knitted into the garment." Expertise for developing space exploration products "can come from lots of seemingly unrelated industries," said Jonathan Cirtain, CEO of Axiom Space... The new product follows Prada's splashy foray into space fashion in 2024 with the unveiling of a spacesuit that is expected to be used for NASA's anticipated Artemis 4 moon landing in 2028...

Other fashion and apparel companies have jumped on the space bandwagon. Under Armour has partnered with spaceflight company Virgin Galactic to create space apparel, while Columbia Sportswear has worked with space exploration company Intuitive Machines on space fabric technology.
The new "Liquid Cooling and Ventilation Garment" was displayed on a mannequin at an event at Prada's Manhattan store.

Science magazine reports: For decades, string theory promised a "theory of everything" that described all particles and forces as tiny vibrating strings. Physicists hoped it could also solve one of the field's deepest problems: reconciling quantum mechanics with gravity. But as string theory grew increasingly elaborate — and experimentally unreachable — many physicists lost hope.

Now, some researchers are revisiting the theory from first principles. In a paper in press at Physical Review Letters, Clifford Cheung, a physicist at the California Institute of Technology, and colleagues lay out a small set of assumptions about the universe and show that they inevitably give rise to string theory.... Cheung's study, along with another one posted to arXiv in January, starts with two reasonably conservative assumptions: that the probabilities of all possible outcomes of an event add up to 100%, and that the laws of physics are consistent for observers moving at different speeds. Each group then posits additional assumptions that have not been borne out by observations. Cheung's analysis invokes "ultrasoftness," the idea that the probability of certain particle interactions drops off at a particular rate at high energies. The second study, led by University of Michigan physicist Henriette Elvang, instead assumes "supersymmetry," a maximal coupling between matter and forces. Both groups conclude the only theory that can satisfy their assumptions is one that looks like string theory...

Cheung and Elvang stress that their aim is not to prove the inevitability of string theory. "I don't have a dog in the fight; I just work here," Cheung says. Rather, the goal is to explore the space of possible theories under rigid constraints — regardless of whether they reflect reality... The one thing the researchers all agree on is that the field would benefit from more alternative models to string theory. Cheung sees the agnostic, bottom-up exploration as a step in that direction. "You can either give up on the problem because it's too culturally toxic, or you can ask: If you want to find an alternative, what do you need?" he says. "Now, we know exactly what to do."
Thanks to Slashdot reader sciencehabit for sharing the article.

"A DNA-editing feat involving editing the genes of early stage embryos was announced this week," reports the Wall Street Journal.

They describe the feat as "a far cry from designer babies, but nevertheless a step in that direction." Dieter Egli, an associate professor of developmental cell biology at Columbia University and his co-authors, including Nathan Treff of Nucleus Genomics, a New York-based DNA-testing startup, say the technology could help fix disease-causing mutations in embryos. "We're not throwing the final 'OK, you will have gene-edited babies tomorrow' at the public," said Egli. "That is a process that can occur through discussion matched with scientific progress...."

Previous gene-editing efforts have often used Crispr, which can cut out parts of the DNA sequence, but the technology can also cause damage if the wrong DNA is targeted or cut out. In 2018, Chinese scientist He Jianku said he used Crispr to tweak DNA in human embryos and was imprisoned for the work. The technology Egli's group used, called base editing, allows them to target individual DNA letters in sequences more precisely with fewer adverse effects... Egli's group focused on altering two genes, one that can raise the risk of heart disease and one that is tied to blood disorders like sickle cell disease, and the research showed they were sometimes able to do so successfully, in the same embryo, without damage.

"I am generally supportive of the concept of embryo editing to prevent genetic disease," said Dr. Paula Amato, a fertility expert at Oregon Health & Science University who wasn't involved in the research... Base editing has been used in human embryos before, according to peer-reviewed studies. The technology was used to correct a disease-causing mutation and an Alzheimer's disease-risk gene variant, said Alexis Komor, associate professor of biochemistry and molecular biophysics at the University of California, San Diego, who wasn't involved in the work. "There really is not any unmet medical or clinical need for this, especially from an in vitro fertilization perspective," Komor said. "Usually what you'll hear is that they're doing it just so that you know we can prevent genetic diseases, but there are so many other better ways to do that."

Using embryo editing to create babies is illegal in the U.S. and many other countries. Scientists have long worried that it is a slippery slope and that the technology could ultimately be used to promote eugenics. Her worry is that "they're basically building a blueprint" for more ethically problematic forms of embryo editing. "In my opinion, I think this is a huge no-no," Komor said. "There's just no ethical way to use this...."

Nucleus Genomics Chief Executive Kian Sadeghi said his company plans to fund Egli's further research, building on the new findings. His company sells a polygenic embryo-screening product, which screens prospective parents' embryos and produces risk scores for their likelihood of developing disease, as well as factors like height, IQ and eye color. The company has said the IQ predictions are limited in accuracy.
The research was published online Monday on a preprint server.

Scientists "have made a discovery that may help prevent some people from developing lung cancer," reports the New York Times, noting that lung cancer "kills more people worldwide than any other cancer." A team of more than 80 researchers working across four continents have identified a set of proteins in the blood that accurately predict lung cancers more than five years before diagnosis. The scientists also found early evidence that an existing anti-inflammatory drug could significantly reduce lung cancer risk in people with elevated concentrations of these proteins, which they linked to inflammation. More research is needed before a test based on these proteins could be ready for use in patients. And scientists would still need to run a randomized trial to determine whether the drug prevents lung cancers. Still, outside experts said the findings, which were published on Thursday in the journal Cell, offer a promising starting point toward a long-held public health goal...

Led by Dr. Swanton, Dr. Tej Pandya, a Ph.D. student, and other researchers took a set of 48,000 blood samples from the UK Biobank and used machine learning to identify 14 proteins associated with the development of lung cancer. When the researchers looked at the presence of those proteins and also took into account a patient's age, smoking status and history of lung disease, they were able to predict who would develop lung cancer more accurately than the best risk assessment models currently in use...

Using mouse and cell models, the scientists showed that these proteins increased when a specific inflammatory pathway was activated. Smoking and air pollution can activate that pathway. This adds to the evidence that it isn't just genetic mutations caused by smoking, pollution or other factors that are driving lung cancers. Rather, Dr. Swanton said, the findings suggest that "smoke causes mutations and inflammation, which together cause cancer." They also found that the signature was increased in people who later developed chronic obstructive pulmonary disease and pulmonary fibrosis, pointing to a common inflammatory environment upstream of all three diseases.

After 50 years of searching, astronomers say they have finally found evidence of a long-sought "wind" blowing from Sagittarius A*, the supermassive black hole at the center of the Milky Way. "Unless a black hole exists in a perfect vacuum, it must blow a wind somehow. And there is no perfect vacuum in the universe," team co-leader and Northwestern University researcher Mark Gorski said in a statement. "With new observations, this is the first time we've had a clean enough view to see the wind's imprint. We looked at the data and said, 'There it is. There is the thing that everybody's been looking for for 50 years.'" Space.com reports: Scientists have been aware for some time that feeding black holes launch powerful outflows of material around them, including jets and winds. Winds are caused when matter falling to the black hole is accelerated to near light-speed, generating pressure that pushes infalling material away. That has been seen with ravenously feeding black holes before, but not the barely feeding Sgr A*. Its sparse consumption of material and the fact it is obscured by the plane of the Milky Way from our vantage point have made tracing this wind difficult.

Gorski's Northwestern colleague and team co-leader Lena Murchikova pointed out that the scientists were the first to detect molecular gas very close to Sgr A* feeding the supermassive black hole. That makes Sgr A* reassuringly like other supermassive black holes. "The wind is not powerful, and its direction probably wanders with time. It shows that our black hole is not unique, and our place in the universe is not unique," Murchikova added. "To observe our own black hole, we have to look through the plane of our galaxy. That means we have to peer through gas, dust and ionized structures, and you can't really see through all of that easily."

While the team's results confirm that Sgr A* is extremely quiet compared to the supermassive black holes that sit in bright, turbulent regions of other galaxies called active galactic nuclei (AGN), this black hole wind is no slouch. In fact, the scientists think that it has been raging for around 20,000 years. "The majority of other galaxies spend most of their lives in a state where they are not particularly active," Murchikova said. "But we can only see them when they are in a fireworks stage. It is very attractive to study black holes when they are in the fireworks stage, but that's not actually their dominant state. "Sgr A* finally gives us a window into the life of a black hole in this quiet state." The team's research was published in The Astrophysical Journal Letters.