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United Kingdom

Deadly Drug-Resistant Fungus Sparks Outbreaks In UK (arstechnica.com) 146

An anonymous reader quotes a report from Ars Technica: More than 200 patients in more than 55 UK hospitals were discovered by healthcare workers to be infected or colonized by the multi-drug resistant fungus Candida auris, a globally emerging yeast pathogen that has experts nervous. Three of the hospitals experienced large outbreaks, which as of Monday were all declared officially over by health authorities there. No deaths have been reported since the fungus was first detected in the country in 2013, but 27 affected patients have developed blood infections, which can be life-threatening. And about a quarter of the more than 200 cases were clinical infections. Officials in the UK aimed to assuage fear of the fungus and assure patients that hospitals were safe. "Our enhanced surveillance shows a low risk to patients in healthcare settings. Most cases detected have not shown symptoms or developed an infection as a result of the fungus," Dr Colin Brown, of Public Health England's national infection service, told the BBC.

Yet, public health experts are uneasy about the rapid emergence and level of drug resistance the pathogen is showing. In a surveillance update in July, the U.S. Centers for Disease Control and Prevention said that C. auris "presents a serious global health threat." It was first identified in the ear of a patient in Japan in 2009. Since then, it has spread swiftly, showing up in more than a dozen countries, including the U.S., according to the CDC. So far, health officials have reported around 100 infections in nine U.S. states and more than 100 other cases where the fungus was detected but wasn't causing an infection.

Power

Australian Scientists Figure Out How Zinc-Air Batteries Can Replace Lithium-Ion Batteries (gizmodo.com.au) 118

Researchers at the University of Sydney has figured out how to solve one of the biggest problems standing in the way for zinc-air batteries to replace lithium-ion batteries. The reason zinc batteries are so sought after is because they're powered by zinc metal -- the 24th most abundant element in Earth's crust. Not only are they cheaper to produce than lithium-ion batteries, they can theoretically store five times more energy, are much safer and environmentally friendly. The problem with zinc batteries stems around them being difficult to charge because of the lack of electrocatalysts needed to reduce and generate oxygen during the discharging and charging of a battery. labnet shares a report from Gizmodo: "Up until now, rechargeable zinc-air batteries have been made with expensive precious metal catalysts, such as platinum and iridium oxide. In contrast, our method produces a family of new high-performance and low-cost catalysts." These new catalysts are produced through the simultaneous control of the composition, size and crystallinity of metal oxides of earth-abundant elements like iron, cobalt and nickel. They can then be applied to build rechargeable zinc-air batteries. Researcher Dr Li Wei, also from the University's Faculty of Engineering and Information Technologies, said trials of zinc-air batteries developed with the new catalysts had demonstrated "excellent rechargeability" -- including less than a 10 percent battery efficacy drop over 60 discharging/charging cycles of 120 hours. The research was published in the journal Advanced Materials.
Science

Tiny Robots Crawl Through Mouse's Stomach To Release Antibiotics (newscientist.com) 15

Tiny robotic drug deliveries could soon be treating diseases inside your body. For the first time, micromotors -- autonomous vehicles the width of a human hair -- have cured bacterial infections in the stomachs of mice, using bubbles to power the transport of antibiotics. From a report: "The movement itself improves the retention of antibiotics on the stomach lining where the bacteria are concentrated," says Joseph Wang at the University of California San Diego, who led the research with Liangfang Zhang. In mice with bacterial stomach infections, the team used the micromotors to administer a dose of antibiotics daily for five days. At the end of the treatment, they found their approach was more effective than regular doses of medicine. The tiny vehicles consist of a spherical magnesium core coated with several different layers that offer protection, treatment, and the ability to stick to stomach walls. After they are swallowed, the magnesium cores react with gastric acid to produce a stream of hydrogen bubbles that propel the motors around. This process briefly reduces acidity in the stomach. The antibiotic layer of the micromotor is sensitive to the surrounding acidity, and when this is lowered, the antibiotics are released.
Medicine

Energy Drinks May Trigger Future Substance Use, Says Study (medscape.com) 233

New research suggests persistent consumption of energy drinks may predispose young adults to substance use. "Investigators, led by Amelia M. Arria, PhD, School of Public Health, University of Maryland, College Park, found that college students who regularly drink highly caffeinated energy drinks were at increased risk for later use of alcohol, cocaine, or prescription stimulants," reports Medscape. From the report: The research included students enrolled in an ongoing longitudinal study that began in 2004 at a large public university. The analysis included 1099 participants (54% women; 72% non-Hispanic white) who completed at least one annual assessment in which patterns of energy drink consumption were assessed. In interviews, participants were asked which energy drinks they had consumed, and how often, in the past year. They were categorized into three patterns of use: Frequent (52 or more days); Occasional (12 - 51 days); Infrequent (1 - 11 days). The investigators found that sensation seeking, conduct problems, and behavioral dysregulation were all positively associated with a higher probability of energy drink consumption, with the nonuse group having the lowest and the persistent group the highest risk scores. The study was published in the journal Drug and Alcohol Dependence.

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