Biotech

DNA Mutations Discovered In the Children of Chernobyl Workers (sciencealert.com) 38

Researchers performed genome sequencing scans on 130 people whose fathers were Chernobyl cleanup workers. Comparing the scans to control groups, they found evidence for the first time for "a transgenerational effect" from the father's prolonged exposure to low-dose ionizing radiation.

ScienceAlert reports: Rather than picking out new DNA mutations in the next generation, they looked for what are known as clustered de novo mutations (cDNMs): two or more mutations in close proximity, found in the children but not the parents. These would be mutations resulting from breaks in the parental DNA caused by radiation exposure. "We found a significant increase in the cDNM count in offspring of irradiated parents, and a potential association between the dose estimations and the number of cDNMs in the respective offspring," write the researchers in their published paper... This fits with the idea that radiation creates molecules known as reactive oxygen species, which are able to break DNA strands — breaks which can leave behind the clusters described in this study, if repaired imperfectly.

The good news is that the risk to health should be relatively small: children of exposed parents weren't found to have any higher risk of disease. This is partly because a lot of the cDNMs likely fall in 'non-coding' DNA, rather than in genes that directly encode proteins.

Space

Analysis of JWST Data Finds - Old Galaxies in a Young Universe? (phys.org) 33

Two astrophysicists at Spain's Instituto de Astrofísica de Canarias analyzed data from the James Webb Space Telescope — the most powerful telescope available — on 31 galaxies with an average redshift of 7.3 (when the universe was 700 million years old, according to the standard model). "We found that they are on average ~600 million years old old, according to the comparison with theoretical models based on previous knowledge of nearby galaxies..."

"If this result is correct, we would have to think about how it is possible that these massive and luminous galaxies were formed and started to produce stars in a short time. It is a challenge."

But "The fact that some of these galaxies might be older than the universe, within some significant confidence level, is even more challenging." The most extreme case is for the galaxy JADES-1050323 with redshift 6.9, which has, according to my calculation, an age incompatible to be younger than the age of the universe (800 million years) within 4.7-sigma (that is, a probability that this happens by chance as statistical fluctuation of one in one million).

If this result is confirmed, it would invalidate the standard Lambda-CDM cosmological model. Certainly, such an extraordinary change of paradigm would require further corroboration and other stronger evidence. Anyway, it would be interesting for other researchers to try to explain the Spectral Energy Distribution of JADES-1050323 in standard terms, if they can ... and without introducing unrealistic/impossible models of extinction, as is usually done.

The findings are published in the journal Monthly Notices of the Royal Astronomical Society.
Medicine

Additional Benefits For Brain, Heart, and Lungs Found for Drugs Like Viagra and Cialis (telegraph.co.uk) 35

"Research published in the World Journal of Men's Health found evidence that drugs such as Viagra and Cialis may also help with heart disease, stroke risk and diabetes," reports the Telegraph, "as well as enlarged prostate and urinary problems." Researchers found evidence that the same mechanism may benefit other organs, including the heart, brain, lungs and urinary system. The paper reviewed a wide range of published studies [and] identified links between PDE5 inhibitor use and improvements in cardiovascular health. Heart conditions were repeatedly cited as an area where improved blood flow and muscle relaxation may offer benefits. Evidence also linked PDE5 inhibitors with reduced stroke risk, likely to be related to improved circulation and vascular function. Diabetes was another condition where associations with improvement were identified... The review also found evidence of benefit for men with an enlarged prostate, a condition that commonly causes urinary symptoms.

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