After a successful November 27th launch to the International Space Station, Russia discovered an accident had occurred on their launch site's mobile maintenance cabin — when a drone spotted it lying upside down in a flame trench. "The main issue with the structure collapse is that it puts Site 31/6 — the only Russian launch site capable of launching crew and cargo to the International Space Station (ISS) — out of service until the structure is fixed," reports the space-news site NASA Spaceflight There are other Soyuz 2 rocket launch pads, but they are either located at an unsuitable latitude, like Plesetsk, or not certified for crewed flights, like Vostochny, or decommissioned and transferred to a museum, like Gagarin's Start at Baikonur. As a result, Russia is temporarily unable to launch Soyuz crewed spacecraft and Progress cargo ships to the ISS, whose nearest launch (Progress MS-33) was scheduled for December 21....

When the rocket launched, a pressure difference was created between the space under the rocket, where gases from running engines are discharged, and the nook where the [144-ton] maintenance cabin was located. The resulting pressure difference pulled the service cabin out of the nook and threw it into the flame trench, where it fell upside down from a height of 20 m. Photos of the accident showed significant damage to the maintenance cabin, which, according to experts, is too extensive to allow for repairs. The only way to resume launches from Site 31/6 is to install a spare maintenance cabin or construct a new one.

Despite the fact that the fallen structure was manufactured in the 1960s, two similar service cabins were manufactured recently at the Tyazhmash heavy-engineering plant in Syzran for other Soyuz launch complexes at the Guiana Space Center and Vostochny Cosmodrome. The production of each cabin took around two years to complete, however, it was not for an emergency situation.
"Various experts gave different possible estimates of the recovery time of the Site 31 launch complex: from several months to three years."

An anonymous reader shared this report from The Conversation: To make interplanetary travel faster, safer, and more efficient, scientists need breakthroughs in propulsion technology. Artificial intelligence is one type of technology that has begun to provide some of these necessary breakthroughs. We're a team of engineers and graduate students who are studying how AI in general, and a subset of AI called machine learning in particular, can transform spacecraft propulsion. From optimizing nuclear thermal engines to managing complex plasma confinement in fusion systems, AI is reshaping propulsion design and operations. It is quickly becoming an indispensable partner in humankind's journey to the stars...

Early nuclear thermal propulsion designs from the 1960s, such as those in NASA's NERVA program, used solid uranium fuel molded into prism-shaped blocks. Since then, engineers have explored alternative configurations — from beds of ceramic pebbles to grooved rings with intricate channels... [T]he more efficiently a reactor can transfer heat from the fuel to the hydrogen, the more thrust it generates. This area is where reinforcement learning has proved to be essential. Optimizing the geometry and heat flow between fuel and propellant is a complex problem, involving countless variables — from the material properties to the amount of hydrogen that flows across the reactor at any given moment. Reinforcement learning can analyze these design variations and identify configurations that maximize heat transfer.

Psychology Today reports: In a study conducted in Milan, Italy, and published in November 2025, the sight of a person dressed as Batman led to a nearly doubled rate of people giving up their seat to a pregnant woman. Over the course of 138 subway rides, researchers found that people who saw "Batman" standing near the pregnant woman were far more altruistic than those who did not.

Researchers are calling this the "Batman effect," suggesting a form of "involuntary" mindfulness may be at play. Noticing these subtle social cues appears to shift people's typical, automatic reactions. Most interestingly, 44 percent of the people questioned reported they did not even consciously register Batman's presence... The superhero costume serves as a visual nudge, pulling us out of our default, self-focused mode and into a more generous, attentive state.
More from Futurism: Batman showing up is just one — albeit striking — way of promoting what's called "prosocial behavior," or the act of helping others around you, via introducing an unexpected event, the researchers write. "Our findings are similar to those of previous research linking present-moment awareness (mindfulness) to greater prosociality," said study lead author Francesco Pagnini, a professor of clinical psychology at the Università Cattolica in Milan, in a statement about the work. "This may create a context in which individuals become more attuned to social cues."
Thanks to Black Parrot (Slashdot reader #19,622) for sharing the article.

A new study published in Communications Earth & Environment has reconstructed the climate conditions of the ancient Indus River Valley civilization between 3000 and 1000 B.C., finding that four intense droughts -- each lasting more than 85 years -- likely drove the gradual decline of one of the world's earliest advanced societies.

The research team, led by Hiren Solanki at the Indian Institute of Technology, Gandhinagar, combined paleoclimate data from cave formations and lake records with computer models to determine that the region shifted from wetter-than-present monsoon conditions to prolonged dry spells as the tropical Pacific Ocean warmed. The third drought, peaking around 1733 B.C., proved the most severe: it lasted 164 years, reduced annual rainfall by 13%, and affected nearly the entire region.

Overall temperatures rose by 0.5 degrees Celsius and rainfall dropped between 10 and 20%. These changes shrank lakes and rivers, dried soils, and made agriculture increasingly difficult in areas away from major waterways. Harappan settlements progressively relocated eastward toward the Indus River over roughly 2,000 years. The civilization's long survival under repeated climate stress -- through crop switching, trade diversification, and settlement relocation -- offers lessons for modern communities facing environmental pressures, the researchers said.

Twenty years after surgeons in France performed the world's first face transplant, the experimental field that procedure launched is now confronting a troubling record of patient deaths, buried negative data and a healthcare system that leaves recipients financially devastated and medically vulnerable.

About 50 face transplants have been performed globally since Isabelle Dinoire received her partial face graft at University Hospital CHU Amiens-Picardie in November 2005. A 2024 JAMA Surgery study reported five-year graft survival of 85% and 10-year survival of 74%, concluding that the procedure is "an effective reconstructive option for patients with severe facial defects." The study did not track psychological wellbeing, financial outcomes, employment status or quality of life. Roughly 20% of face transplant patients have died from rejection, kidney failure, or heart failure.

The anti-rejection medications that keep transplanted faces alive can destroy kidneys and weaken immune systems to the point where routine infections become life-threatening. In the United States, the Department of Defense has funded most operations, treating them as a frontier for wounded veterans, because private insurers refuse to cover the costs. Patients who survive the surgery often find themselves unable to afford medications, transportation to follow-up appointments or basic caregiving. The field's long-term grants cover surgical innovation but not the lifelong needs of the people who receive these transplants.

An anonymous reader shares a report: NASA has slashed the number of astronaut missions on Boeing's Starliner contract and said the spacecraft's next mission to the International Space Station will fly without a crew, reducing the scope of a program hobbled by engineering woes and outpaced by SpaceX. The most recent mishap occurred during Starliner's first crewed test flight in 2024, carrying NASA astronauts Butch Wilmore and Suni Williams. Several thrusters on Starliner's propulsion system shut down during its approach to the ISS.

China's new JUNO neutrino observatory has delivered world-leading measurements after just 59 days, offering the most precise readings yet of two key neutrino oscillation parameters. "The physics result is already world-leading in the areas that it touches," says particle physicist Juan Pedro Ochoa-Ricoux of the University of California, Irvine, who co-leads a team on JUNO. "In particular, we measured two neutrino oscillation parameters, and that measurement is already for both parameters the best in the world." The results were published in two separate preprints on arXiv.org. Scientific American reports: JUNO's spherical detector, which is akin to a 13-story-tall fishbowl, primarily measures so-called electron antineutrinos spewing from the nearby Yangjian and Taishan nuclear plants. When the particles strike a proton inside the detector, a reaction triggers two light flashes that ping photomultiplier tubes and get converted into electrical signals. The new measurements from these neutrino-proton collisions are now considered the most precise for two oscillation parameters, which act as proxies for differences in their mass, according to Ochoa-Ricoux.

"It is the first time we've turned on a scientific instrument like JUNO that we've been working on for over a decade. It's just tremendously exciting," Ochoa-Ricoux says. "And then to see that we're able to already do world-leading measurements with it, even with such a small amount of data, that's also really exciting." Still, the physicists will need years' worth of neutrino detections to answer the mass-ordering conundrum.

China's pharmaceutical industry has quietly evolved from a hub for generics and clinical trials into something more ambitious -- a genuine competitor in drug discovery that Western giants are now courting to fill gaps left by looming patent expirations worth over $300 billion by 2030. In the first half of 2025, nearly a third of global licensing agreements signed by big pharma involved Chinese firms, Economist reports, four times the share from 2021. Pfizer agreed in May to pay $1.25 billion to 3SBio for an experimental cancer drug, and GlaxoSmithKline followed in June with a deal valued at up to $12 billion with Hengrui. Chinese companies now run about a third of the world's clinical trials, up from 5% a decade ago.

An anonymous reader shares a report: It is shocking but not surprising. Lightning crackles on Mars, scientists reported on Wednesday. What they observed, however, were not jagged, high-voltage bolts like those on Earth, arcing thousands of feet from cloud to ground. Rather, the phenomenon was more like the shock you feel when you scuff your feet on the carpet on a cold winter morning and then touch a metal doorknob.

"This is like mini-lightning on Mars," Baptiste Chide, a scientist at the Research Institute in Astrophysics and Planetary Science in Toulouse, France, said of the centimeter-scale electrical discharges. Dr. Chide and his colleagues reported the findings in a paper published on Wednesday in the journal Nature. The electrical sparks, although not as dramatically violent as on Earth, could play an important role in chemical reactions in the Martian atmosphere.

An anonymous reader quotes a report from the Guardian: Nearly a century ago, scientists proposed that a mysterious invisible substance they named dark matter clumped around galaxies and formed a cosmic web across the universe. What dark matter is made from, and whether it is even real, are still open questions, but according to a study, the first direct evidence of the substance may finally have been glimpsed. More work is needed to rule out less exotic explanations, but if true, the discovery would go down as a turning point in the decades-long search for the elusive substance that is said to make up 27% of the cosmos.

"This could be a crucial breakthrough in unraveling the nature of dark matter," said Prof Tomonori Totani, an astrophysicist at the University of Tokyo, who said gamma rays emanating from the centre of the Milky Way appeared to bear the signature of the substance. [...] To search for potential dark matter signals, Totani analysed data from Nasa's Fermi Gamma-ray Space Telescope, which detects the most energetic photons in the electromagnetic spectrum. He spotted a pattern of gamma rays that appeared to match the shape of the dark matter halo that spreads out in a sphere from the heart of the galaxy. The signal "closely matches the properties of gamma-ray radiation predicted to be emitted by dark matter," Totani told the Guardian. Details are published in the Journal of Cosmology and Astroparticle Physics.

If Totani has seen dark matter at work, the observations suggest it is made from elementary particles 500 times more massive than the proton. But far more work is needed to rule out other astrophysical processes and background emissions that could explain the signals. Totani said the "decisive factor" would be detecting gamma rays with the same spectrum from other regions of space, such as dwarf galaxies. According to Prof Justin Read, an astrophysicist at the University of Surrey, the lack of significant signals from such galaxies strongly argues against Totani having seen gamma rays emitted from dark matter particle annihilation. Prof Kinwah Wu, a theoretical astrophysicist at UCL, urged caution, saying: "I appreciate the author's hard work and dedication, but we need extraordinary evidence for an extraordinary claim," he said. "This analysis has not reached this status yet. It is a piece of work which serves as an encouragement for the workers in the field to keep on pressing."

China launched an uncrewed Shenzhou 22 spacecraft to serve as an emergency lifeboat for three astronauts aboard the Tiangong space station after a docked return craft was found to have a cracked window likely caused by space debris. "A Long March 2F rocket fired its engines and lifted off with the Shenzhou 22 spacecraft, carrying cargo instead of a crew, at 11:11 pm EST Monday (04:11 UTC Tuesday)," reports Ars Technica. "The spacecraft docked with the Tiangong station nearly 250 miles (400 kilometers) above the Earth about three-and-a-half hours later." From the report: Chinese engineers worked fast to move up the launch of the Shenzhou 22, originally set to fly next year. On November 4, astronauts discovered one of the two crew ferry ships docked to the Tiangong station had a damaged window, likely from an impact with a small fragment of space junk. [...] Now, 20 days after the saga began, the Tiangong outpost again has a lifeboat for its long-term residents. Astronauts Zhang Lu, Fu Wei, and Zhang Hongzhang will return to Earth on the Shenzhou 22 spacecraft next year, soon after the arrival of their three replacements.

The Tiangong astronauts will head outside the station on a spacewalk to inspect the damaged window on Shenzhou 20. Eventually, Shenzhou 20 will depart Tiangong and reenter the atmosphere with cargo. Assuming a smooth landing, Chinese engineers will have an opportunity to get a closer look at the damage on the ground to inform the design of future spacecraft. A preliminary assessment of the window indicates the crack is in the outermost layer of heat-insulating glass in Shenzhou 20's porthole window, according to Chinese state media. Engineers on the ground conducted simulations and wind tunnel ablation tests to determine whether the window might fail during reentry. "The results showed that the cracks would still propagate further," reported CCTV, China's government-run television network. "We held review meeting, and everyone agreed that ensuring the safe return of the astronauts was too risky with the glass damaged," Zhou said.

While this crew is just one month into their planned six-month expedition, an emergency could force them to leave the station and return home at any time. Although remote, another collision with space junk, a major systems failure, or a medical emergency involving one of the astronauts could trigger an evacuation. That's why Chinese officials wanted to quickly launch Shenzhou 22 to give the crew a ticket home.The International Space Station follows the same policy, with SpaceX's Dragon spacecraft and Russian Soyuz ships serving as lifeboats until their crews' scheduled return to Earth.

The brain goes through five distinct phases in life, with key turning points at ages nine, 32, 66 and 83, scientists have revealed. From a report: Around 4,000 people up to the age of 90 had scans to reveal the connections between their brain cells. Researchers at the University of Cambridge showed that the brain stays in the adolescent phase until our early thirties when we "peak." They say the results could help us understand why the risk of mental health disorders and dementia varies through life. The brain is constantly changing in response to new knowledge and experience -- but the research shows this is not one smooth pattern from birth to death.

Some people will reach these landmarks earlier or later than others -- but the researchers said it was striking how clearly these ages stood out in the data. These patterns have only now been revealed due to the quantity of brain scans available in the study, which was published in the journal Nature Communications.

Researchers warn that rapid advances in neuroscience, pharmacology, and AI are bringing "brain weapons" out of science fiction and into real-world plausibility. They argue current arms treaties don't adequately cover these emerging tools and call for a new, proactive framework to prevent the weaponization of the human mind. The Guardian reports: Michael Crowley and Malcolm Dando, of Bradford University, are about to publish a book that they believe should be a wake-up call to the world. [...] The book, published by the Royal Society of Chemistry, explores how advances in neuroscience, pharmacology and artificial intelligence are coming together to create a new threat. "We are entering an era where the brain itself could become a battlefield," said Crowley. "The tools to manipulate the central nervous system -- to sedate, confuse or even coerce -- are becoming more precise, more accessible and more attractive to states."

The book traces the fascinating, if appalling, history of state-sponsored research into central nervous system (CNS)-acting chemicals. [...] The academics argue that the ability exists to create much more "sophisticated and targeted" weapons that would once have been unimaginable. Dando said: "The same knowledge that helps us treat neurological disorders could be used to disrupt cognition, induce compliance, or even in the future turn people into unwitting agents." The threat is "real and growing" but there are gaps in international arms control treaties preventing it from being tackled effectively, they say. [...]

The book makes the case for a new "holistic arms control" framework, rather than relying on existing arms control treaties. It sets out a number of practical steps that could be taken, including establishing a working group on CNS-acting and broader incapacitating agents. Other proposals concern training, monitoring and definitions. "We need to move from reactive to proactive governance," said Dando. Both men acknowledge that we are learning more about the brain and the central nervous system, which is good for humanity. They said they were not trying to stifle scientific progress and it was about preventing malign intent. Crowley said: "This is a wake-up call. We must act now to protect the integrity of science and the sanctity of the human mind."

Drug maker Novo Nordisk says semaglutide, the active ingredient for the weight loss jab Wegovy, does not slow Alzheimer's -- despite initial hopes that it might help against dementia. From a report: Researchers began two large trials involving more than 3,800 people after reports the medicine was having an impact in the real world. But the studies showed the GLP-1 drug, which is already used to manage type 2 diabetes and obesity, made no difference compared to a dummy drug. The disappointing results are due to be presented at an Alzheimer's disease conference next month and are yet to be published in a peer-reviewed journal.

In 2018 researchers claimed evidence of a lake beneath the surface of Mars, detected by the Mars Advanced Radar for Subsurface and Ionosphere Sounding instrument (or Marsis for short).

But new Mars observations "are not consistent with the presence of liquid water in this location and an alternative explanation, such as very smooth basal materials, is needed." Phys.org explains Aboard the Mars Reconnaissance Orbiter, the Shallow Radar (SHARAD) uses higher frequencies than MARSIS. Until recently, though, SHARAD's signals couldn't reach deep enough into Mars to bounce off the base layer of the ice where the potential water lies — meaning its results couldn't be compared with those from MARSIS. However, the Mars Reconnaissance Orbiter team recently tested a new maneuver that rolls the spacecraft on its flight axis by 120 degrees — whereas it previously could roll only up to 28 degrees. The new maneuver, termed a "very large roll," or VLR, can increase SHARAD's signal strength and penetration depth, allowing researchers to examine the base of the ice in the enigmatic high-reflectivity zone. Gareth Morgan and colleagues, for their article published in Geophysical Research Letters, examined 91 SHARAD observations that crossed the high-reflectivity zone.

Only when using the VLR maneuver was a SHARAD basal echo detected at the site. In contrast to the MARSIS detection, the SHARAD detection was very weak, meaning it is unlikely that liquid water is present in the high-reflectivity zone.

Theia crashed into earth and formed the moon, the theory goes. But then where did Theia come from? The lead author on a new study says "The most convincing scenario is that most of the building blocks of Earth and Theia originated in the inner Solar System. Earth and Theia are likely to have been neighbors."

Though Theia was completely destroyed in the collision, scientists from the Max Planck Institute for Solar System Research led a team that was able to measure the ratio of tell-tale isotopes in Earth and Moon rocks, Euronews explains: The research team used rocks collected on Earth and samples brought back from the lunar surface by Apollo astronauts to examine their isotopes. These isotopes act like chemical fingerprints. Scientists already knew that Earth and Moon rocks are almost identical in their metal isotope ratios. That similarity, however, has made it hard to learn much about Theia, because it has been difficult to separate material from early Earth and material from the impactor.

The new research attempts a kind of planetary reverse engineering. By examining isotopes of iron, chromium, zirconium and molybdenum, the team modelled hundreds of possible scenarios for the early Earth and Theia, testing which combinations could produce the isotope signatures seen today. Because materials closer to the Sun formed under different temperatures and conditions than those further out, those isotopes exist in slightly different patterns in different regions of the Solar System.

By comparing these patterns, researchers concluded that Theia most likely originated in the inner Solar System, even closer to the Sun than the early Earth.
The team published their findings in the journal Science. Its title? "The Moon-forming impactor Theia originated from the inner Solar System."

An anonymous reader shared this report from CNN: The universe's expansion might not be accelerating but slowing down, a new study suggests. If confirmed, the finding would upend decades of established astronomical assumptions and rewrite our understanding of dark energy, the elusive force that counters the inward pull of gravity in our universe...

Last year, a consortium of hundreds of researchers using data from the Dark Energy Spectroscopic Instrument (DESI) in Arizona, developed the largest ever 3D map of the universe. The observations hinted at the fact that dark energy may be weakening over time, indicating that the universe's rate of expansion could eventually slow. Now, a study published November 6 in the journal Monthly Notices of the Royal Astronomical Society provides further evidence that dark energy might not be pushing on the universe with the same strength it used to. The DESI project's findings last year represented "a major, major paradigm change ... and our result, in some sense, agrees well with that," said Young-Wook Lee, a professor of astrophysics at Yonsei University in South Korea and lead researcher for the new study....

To reach their conclusions, the researchers analyzed a sample of 300 galaxies containing Type 1a supernovas and posited that the dimming of distant exploding stars was not only due to their moving farther away from Earth, but also due to the progenitor star's age... [Study coauthor Junhyuk Son, a doctoral candidate of astronomy at Yonsei University, said] "we found that their luminosity actually depends on the age of the stars that produce them — younger progenitors yield slightly dimmer supernovae, while older ones are brighter." Son said the team has a high statistical confidence — 99.99% — about this age-brightness relation, allowing them to use Type 1a supernovas more accurately than before to assess the universe's expansion... Eventually, if the expansion continues to slow down, the universe could begin to contract, ending in what astronomers imagine may be the opposite of the big bang — the big crunch. "That is certainly a possibility," Lee said. "Even two years ago, the Big Crunch was out of the question. But we need more work to see whether it could actually happen."

The new research proposes a radical revision of accepted knowledge, so, understandably, it is being met with skepticism. "This study rests on a flawed premise," Adam Riess, a professor of physics and astronomy at the Johns Hopkins University and one of the recipients of the 2011 Nobel Prize in physics, said in an email. "It suggests supernovae have aged with the Universe, yet observations show the opposite — today's supernovae occur where young stars form. The same idea was proposed years ago and refuted then, and there appears to be nothing new in this version." Lee, however, said Riess' claim is incorrect. "Even in the present-day Universe, Type Ia supernovae are found just as frequently in old, quiescent elliptical galaxies as in young, star-forming ones — which clearly shows that this comment is mistaken. The so-called paper that 'refuted' our earlier result relied on deeply flawed data with enormous uncertainties," he said, adding that the age-brightness correlation has been independently confirmed by two separate teams in the United States and China... "Extraordinary claims require extraordinary evidence," Dragan Huterer, a professor of physics at the University of Michigan in Ann Arbor, said in an email, noting that he does not feel the new research "rises to the threshold to overturn the currently favored model...."

The new Vera C. Rubin Observatory, which started operating this year, is set to help settle the debate with the early 2026 launch of the Legacy Survey of Space and Time, an ultrawide and ultra-high-definition time-lapse record of the universe made by scanning the entire sky every few nights over 10 years to capture a compilation of asteroids and comets, exploding stars, and distant galaxies as they change.

ScienceDaily reports: Electrons can freeze into strange geometric crystals and then melt back into liquid-like motion under the right quantum conditions. Researchers identified how to tune these transitions and even discovered a bizarre "pinball" state where some electrons stay locked in place while others dart around freely. Their simulations help explain how these phases form and how they might be harnessed for advanced quantum technologies...

When electrons settle into these rigid arrangements, the material undergoes a shift in its state of matter and stops conducting electricity. Instead of acting like a metal, it behaves as an insulator. This unusual behavior provides scientists with valuable insight into how electrons interact and has opened the door to advances in quantum computing, high-performance superconductors used in energy and medical imaging, innovative lighting systems, and extremely precise atomic clocks... [Florida State University assistant professor Cyprian Lewandowski said] "Here, it turns out there are other quantum knobs we can play with to manipulate states of matter, which can lead to impressive advances in experimental research."

The Washington Post reports: Scientists in Switzerland have created a robot the size of a grain of sand that is controlled by magnets and can deliver drugs to a precise location in the human body, a breakthrough aimed at reducing the severe side effects that stop many medicines from advancing in clinical trials... "I think surgeons are going to look at this," [said Bradley J. Nelson, an author of the paper in Science describing the discovery and a professor of robotics and intelligent systems at ETH Zurich]. I'm sure they're going to have a lot of ideas on how to use" the microrobot. The capsule, which is steered by magnets, might also be useful in treating aneurysms, very aggressive brain cancers, and abnormal connections between arteries and veins known as arteriovenous malformations, Nelson said. The capsules have been tested successfully in pigs, which have similar vasculature to humans, and in silicone models of the blood vessels in humans and animals... Nelson said drug-ferrying microrobots of this kind may be three to five years from being tested in clinical trials. The problem faced by many drugs under development is that they spread throughout the body instead of going only to the area in need... A major cause of side effects in patients is medications traveling to parts of the body that don't need them. The capsules developed in Switzerland, however, can be maneuvered into precise locations by a surgeon using a tool not that different from a PlayStation controller. The navigation system involves six electromagnetic coils positioned around the patient, each about 8 to 10 inches in diameter... The capsules are made of materials that have been found safe for people in other medical tools...

When the capsule reaches its destination in the body, "we can trigger the capsule to dissolve," Nelson said.

fahrbot-bot shares a report from Phys.org: Physicists from Swansea University have played the leading role in a scientific breakthrough at CERN, developing an innovative technique that increases the antihydrogen trapping rate by a factor of ten. The advancement, achieved as part of the international Antihydrogen Laser Physics Apparatus (ALPHA) collaboration, has been published in Nature Communications and could help answer one of the biggest questions in physics: Why is there such a large imbalance between matter and antimatter? According to the Big Bang theory, equal amounts were created at the beginning of the universe, so why is the world around us made almost entirely of matter?

Antihydrogen is the "mirror version" of hydrogen, made from an antiproton and a positron. Trapping and studying it helps scientists explore how antimatter behaves, and whether it follows the same rules as matter. Producing and trapping antihydrogen is an extremely complicated process. Previous methods took 24 hours to trap just 2,000 atoms, limiting the scope of experiments at ALPHA. The Swansea-led team has changed that. Using laser-cooled beryllium ions, the team has demonstrated that it is possible to cool positrons to less than 10 Kelvin (below -263C), significantly colder than the previous threshold of about 15 Kelvin. These cooler positrons dramatically boost the efficiency of antihydrogen production and trapping -- allowing a record 15,000 atoms to be trapped in less than seven hours.

alternative_right shares a report from Phys.org: Inspired by moss's resilience, researchers sent moss sporophytes -- reproductive structures that encase spores -- to the most extreme environment yet: space. Their results, published in the journal iScience on November 20, show that more than 80% of the spores survived nine months outside of the International Space Station (ISS) and made it back to Earth still capable of reproducing, demonstrating for the first time that an early land plant can survive long-term exposure to the elements of space.

[Lead author Tomomichi Fujita of Hokkaido University and his team] subjected Physcomitrium patens, a well-studied moss commonly known as spreading earthmoss, to a simulated a space environment, including high levels of UV radiation, extreme high and low temperatures, and vacuum conditions. They tested three different structures from the moss -- protenemata, or juvenile moss; brood cells, or specialized stem cells that emerge under stress conditions; and sporophytes, or encapsulated spores -- to find out which had the best chance of surviving in space.

The researchers found that UV radiation was the toughest element to survive, and the sporophytes were by far the most resilient of the three moss parts. None of the juvenile moss survived high UV levels or extreme temperatures. The brood cells had a higher rate of survival, but the encased spores exhibited ~1,000x more tolerance to UV radiation. The spores were also able to survive and germinate after being exposed to 196C for over a week, as well as after living in 55C heat for a month.

A Centers for Disease Control and Prevention webpage that previously made the case that vaccines don't cause autism now says they might. WSJ: The contents of the webpage came up during Health Secretary Robert F. Kennedy Jr. Senate confirmation process. Sen. Bill Cassidy (R., La.) in February said Kennedy had assured him that, if he was confirmed, the CDC would "not remove statements on their website pointing out that vaccines do not cause autism."

The revised webpage says: "The claim 'vaccines do not cause autism' is not an evidence-based claim because studies have not ruled out the possibility that infant vaccines cause autism. Studies supporting a link have been ignored by health authorities." The new text posted Wednesday also notes that the Department of Health and Human Services has launched "a comprehensive assessment" to probe the causes of autism.

An anonymous reader shares a report: For the past several years, America has been using its young people as lab rats in a sweeping, if not exactly thought-out, education experiment. Schools across the country have been lowering standards and removing penalties for failure. The results are coming into focus.

Five years ago, about 30 incoming freshmen at UC San Diego arrived with math skills below high-school level. Now, according to a recent report from UC San Diego faculty and administrators, that number is more than 900 -- and most of those students don't fully meet middle-school math standards. Many students struggle with fractions and simple algebra problems. Last year, the university, which admits fewer than 30 percent of undergraduate applicants, launched a remedial-math course that focuses entirely on concepts taught in elementary and middle school. (According to the report, more than 60 percent of students who took the previous version of the course couldn't divide a fraction by two.) One of the course's tutors noted that students faced more issues with "logical thinking" than with math facts per se. They didn't know how to begin solving word problems.

The university's problems are extreme, but they are not unique. Over the past five years, all of the other University of California campuses, including UC Berkeley and UCLA, have seen the number of first-years who are unprepared for precalculus double or triple. George Mason University, in Virginia, revamped its remedial-math summer program in 2023 after students began arriving at their calculus course unable to do algebra, the math-department chair, Maria Emelianenko, told me.

"We call it quantitative literacy, just knowing which fraction is larger or smaller, that the slope is positive when it is going up," Janine Wilson, the chair of the undergraduate economics program at UC Davis, told me. "Things like that are just kind of in our bones when we are college ready. We are just seeing many folks without that capability."

Part of what's happening here is that as more students choose STEM majors, more of them are being funneled into introductory math courses during their freshman year. But the national trend is very clear: America's students are getting much worse at math. The decline started about a decade ago and sharply accelerated during the coronavirus pandemic. The average eighth grader's math skills, which rose steadily from 1990 to 2013, are now a full school year behind where they were in 2013, according to the National Assessment of Educational Progress, the gold standard for tracking academic achievement. Students in the bottom tenth percentile have fallen even further behind. Only the top 10 percent have recovered to 2013 levels.

Researchers in Germany achieved a major milestone for the future quantum internet by successfully teleporting quantum information between photons generated by two different, physically separated quantum dots -- something never accomplished before due to the difficulty of producing indistinguishable photons from remote sources. Phys.org reports: At the University of Stuttgart, the team succeeded in teleporting the polarization state of a photon originating from one quantum dot to another photon from a second quantum dot. One quantum dot generates a single photon, the other an entangled photon pair. Entangled means that the two particles constitute a single quantum entity, even when they are physically separated. One of the two particles travels to the second quantum dot and interferes with its light particle. The two overlap. Because of this superposition, the information of the single photon is transferred to the distant partner of the pair.

Instrumental for the success of the experiment were quantum frequency converters, which compensate for residual frequency differences between the photons. These converters were developed by a team led by Prof. Christoph Becher, an expert in quantum optics at Saarland University. [...] In the Stuttgart experiment, the quantum dots were separated only by an optical fiber of about 10 m length. "But we are working on achieving considerably greater distances," says Strobel. In earlier work, the team had shown that the entanglement of the quantum dot photons remains intact even after a 36-kilometer transmission through the city center of Stuttgart. Another aim is to increase the current success rate of teleportation, which currently stands at just over 70%. Fluctuations in the quantum dot still lead to slight differences in the photons. The findings have been published in the journal Nature Communications.

A new treatment for tuberculosis could boost cure rates and shorten the time needed to treat the disease by months, trial results suggest. The Guardian: Globally, an estimated 10.7 million people fell ill with TB last year and 1.23 million died from it. In its annual report on tuberculosis, launched last week, the World Health Organization said it remained a "major global public-health problem" and the leading infectious cause of death. [...] Sorfequiline, a new antibiotic, showed stronger action against the deadly bacteria than existing treatments, with a comparable safety profile, researchers from the TB Alliance told the Union Conference on Lung Health in Copenhagen on Wednesday.

The trial involved 309 people across 22 sites in South Africa, the Philippines, Georgia, Tanzania and Uganda, with different dose regimens. All participants had "drug-sensitive" tuberculosis, meaning a standard cocktail of drugs can safely treat them but researchers believe TB infections that are resistant to standard treatment could also be helped. The trial suggested a sorfequiline-based regimen could be used for anyone testing positive, said Dr Maria Beumont, vice-president of TB Alliance.

Action is needed now to reduce ultra-processed food (UPF) in diets worldwide because of their threat to health, say international experts in a global review of research. From a report: They say the way we eat is changing - with a move away from fresh, whole foods to cheap, highly-processed meals - which is increasing our risk of a range of chronic diseases, including obesity and depression. Writing in The Lancet, the researchers say governments need "to step up" and introduce warnings and higher taxes on UPF products, to help fund access to more nutritious foods.

[...] This review of evidence on the impact of UPFs on health, carried out by 43 global experts and based on 104 long-term studies, suggests these foods are linked to a greater risk of 12 health conditions. These include type 2 diabetes, cardiovascular disease, kidney disease, depression and dying prematurely from any cause.

An anonymous reader shares a report: Federal health officials have linked two massive US measles outbreaks, confirming that the country is about two months away from losing its measles elimination status, according to a report by The New York Times. The Times obtained a recording of a call during which officials from the Centers for Disease Control and Prevention confirmed to state health departments that the ongoing measles outbreak at the border of Arizona and Utah is a continuation of the explosive outbreak in West Texas that began in mid- to late-January. That is, the two massive outbreaks are being caused by the same subtype of measles virus.

This is a significant link that hasn't previously been reported despite persistent questions from journalists and concerns from health experts, particularly in light of Canada losing its elimination status last week. The loss of an elimination status means that measles will once again be considered endemic to the US, an embarrassing public health backslide for a vaccine-preventable disease.

A Chinese man who cryogenically preserved his wife after her death has sparked a heated online debate after it emerged he began dating a new partner in 2020. Some argue it's natural for him to move on, while others say he's being selfish or disrespectful to both his late wife and his current partner. The BBC reports: As a sign of his devotion, Gui Junmin decided to freeze his wife Zhan Wenlian's body after she died from lung cancer in 2017, aged 49, making her China's first cryogenically preserved person. But after a November interview revealed he had been dating a different partner since 2020, Chinese social media has been torn on Mr Junmin's predicament. Whilst some asked why the 57-year-old didn't just "let go" another commenter remarked he appeared to be "most devoted to himself."

After Zhan Wenlian was given months to live by doctors, Gui Junmin decided to use cryonics - which is scientifically unproven - to preserve her body once she died. Following her death, he signed a 30-year agreement to preserve his wife's frozen body with the Shandong Yinfeng Life Science Research Institute. Since then, Zhan's body has been stored in a 2,000-litre container at the institute in a vat of -190C liquid nitrogen.

Chinese newspaper Southern Weekly revealed that although Mr Junmin lived alone for two years after the procedure, in 2020 he began dating again, despite his wife remaining in cryopreservation. He told the newspaper that a severe gout attack which left him unable to move for two days began to change his mind about the benefits of living alone. Soon after, he started seeing his current partner Wang Chunxia, although Mr Junmin suggested to the paper the love was only "utilitarian" and that she hadn't "entered" his heart.

UC Berkeley researchers working with Project CETI discovered that sperm whales produce vowel-like sounds embedded in their click codas, suggesting a far more complex communication system than previously understood. "It was striking just how structured the system was. I've never seen anything like that before with other animals," Begus, a UC Berkeley linguistics professor and the linguistics lead at Project CETI, told SFGATE. "We're showing the world that there's more than meets the eye in sperm whales and that, if one cares to look closely, they're not as alien. We're much more similar to each other than we used to think." SFGATE reports: With the help of a machine-learning model to identify patterns, Begus and his team combed through recordings collected from social units of sperm whales off the coast of the island of Dominica between 2005 and 2018. When they sped up the audio, removing the silences between clicks, they heard new patterns. They found acoustic properties that share similarities with two vowels -- a and i -- and several vowel combinations.

"Before, people were looking just at the timing and the number of clicks exchanged between sperm whales, but now we have to look at the frequencies, too. A whole new set of patterns have appeared," Begus said. "Now, it's one of the most complex non-human communication systems we have observed." [...] Begus said the research only shows how much more we have to learn about whales' style of communicating. He is particularly interested in exploring how the system may differ for whales between regions and how whale babies learn to communicate in this way. Most importantly, he wants to understand the meaning behind the sounds, as a "window into whale thoughts and lives." The research was published in the journal Open Mind.

An anonymous reader quotes a report from the New York Times: For the first time, scientists are tracking the migration of monarch butterflies across much of North America, actively monitoring individual insects on journeys from as far away as Ontario all the way to their overwintering colonies in central Mexico. This long-sought achievement could provide crucial insights into the poorly understood life cycles of hundreds of species of butterflies, bees and other flying insects at a time when many are in steep decline.

The breakthrough is the result of a tiny solar-powered radio tag that weighs just 60 milligrams and sells for $200. Researchers have tagged more than 400 monarchs this year and are now following their journeys on a cellphone app created by the New Jersey-based company that makes the tags, Cellular Tracking Technologies. Most monarchs weigh 500 to 600 milligrams, so each tag-bearing migrator making the transcontinental journey is, by weight, equivalent to a half-raisin carrying three uncooked grains of rice.

Researchers are tracking more than 400 tagged monarch butterflies as they fly toward winter colonies in central Mexico. The maps [in the article] follow six butterflies. [...] Tracking the world's most famous insect migration may also have a big social impact, with monarch lovers able to follow the progress of individual butterflies on the free app, called Project Monarch Science. Many of the butterflies are flying over cities and suburbs where pollinator gardens are increasingly popular. Some tracks could even lead to the discovery of new winter hideaways. "There's nothing that's not amazing about this," said Cheryl Schultz, a butterfly scientist at Washington State University and the senior author of a recent study documenting a 22 percent drop in butterfly abundance in North America over a recent 20-year period. "Now we will have answers that could help us turn the tide for these bugs."

alternative_right shares a report from ScienceAlert: A new study from researchers in Australia reveals that the people who never forget faces look "smarter, not harder." In other words, they naturally focus on a person's most distinguishing facial features. "Their skill isn't something you can learn like a trick," explains lead author James Dunn, a psychology researcher at the University of New South Wales (UNSW) Sydney. "It's an automatic, dynamic way of picking up what makes each face unique."

To see what super-recognizers see, Dunn and his colleagues used eye-tracking technology to reconstruct how people surveyed new faces. They did this with 37 super-recognizers and 68 people with ordinary facial recognition skills, noting where and for how long participants looked at pictures of faces displayed on a computer screen. The researchers then fed the data into machine learning algorithms trained to recognize faces. The algorithms, a type known as deep neural networks, were tasked with deciding if two faces belonged to the same person. "These findings suggest that the perceptual foundations of individual differences in face recognition ability may originate at the earliest stages of visual processing -- at the level of retinal encoding," Dunn and colleagues write in their paper.

The findings have been published in the journal Proceedings of the Royal Society B: Biological Sciences.

"To be clear, the current economics of space-based data centers don't make sense," writes the Wall Street Journal.

"But they could in the future, perhaps as soon as a decade or so from now, according to an analysis by Phil Metzger, a research professor at the University of Central Florida and formerly of the National Aeronautics and Space Administration." "Space enthusiasts (comme moi) have long sought a business case to enable human migration beyond our home world," he posted on X amid the new hype. "I think AI servers in space is the first real business case that will lead to many more...."

The argument essentially boils down to the belief that AI's needs are eventually going to grow so great that we need to move to outer space. There the sun's power can be more efficiently harvested. In space, the sun's rays can be direct and constant for solar panels to collect — no clouds, no rainstorms, no nighttime. Demands for cooling could also be cut because of the vacuum of space. Plus, there aren't those pesky regulations that executives like to complain about, slowing construction of new power plants to meet the data-center needs. In space, no one can hear the Nimbys scream. "We will be able to beat the cost of terrestrial data centers in space in the next couple of decades," Bezos said at a tech conference last month. "Space will end up being one of the places that keeps making Earth better."

It's still early days. At Alphabet, Google's plans sound almost conservative. The search-engine company in recent days announced Project Suncatcher, which it describes as a moonshot project to scale machine learning in space. It plans to launch two prototype satellites by early 2027 to test its hardware in orbit. "Like any moonshot, it's going to require us to solve a lot of complex engineering challenges," Pichai posted on social media. Nvidia, too, has announced a partnership with startup Starcloud to work on space-based data centers. Not to be outdone, Elon Musk has been painting his own updated vision for the heavens... in recent weeks he has been talking more about how he can use his spaceships to deploy new versions of his solar-powered Starlink satellites equipped with high-speed lasers to build out in-space data centers.

On Friday, Musk further reiterated how those AI satellites would be able to generate 100 gigawatts of annual solar power — or, what he said, would be roughly a quarter of what the U.S. consumes on average in a year. "We have a plan mapped out to do it," he told investor Ron Baron during an event. "It gets crazy." Previously, he has suggested he was four to five years away from that ability. He's also touted even wilder ideas, saying on X that 100 terawatts a year "is possible from a lunar base producing solar-powered AI satellites locally and accelerating them to escape velocity with a mass driver." Simply put, he's suggesting a moon base will crank out satellites and throw them into orbit with a catapult. And those satellites' solar panels would generate 100,000 gigawatts a year. "I think we'll see intelligence continue to scale all the way up to where...most of the power of the sun is harnessed for compute," Musk told a tech conference in September.

"Three Chinese astronauts returned from their nation's space station Friday," reports the Associated Press, "after more than a week's delay because the return capsule they had planned to use was damaged, likely from being hit by space debris." The team left their Shenzhou-20 spacecraft in orbit and came back using the recently arrived Shenzhou-21, which had ferried a three-person replacement crew to the station, China's Manned Space Agency said. The original return plan was scrapped because a window in the Shenzhou-20 capsule had tiny cracks, most likely caused by impact from space debris, the space agency said Friday... Their return was delayed for nine days, and their 204-day stay in space was the longest for any astronaut at China's space station...

China developed the Tiangong space station after the country was excluded from the International Space Station over U.S. national security concerns. China's space program is controlled by its military.

An anonymous reader shared this report from the Guardian: The number of deaths linked to superbugs that do not respond to frontline antibiotics increased by 17% in England last year, according to official figures that raise concerns about the ongoing increase in antimicrobial resistance.

The figures, released by the UK Health Security Agency, also revealed a large rise in private prescriptions for antibiotics, with 22% dispensed through the private sector in 2024. The increase in private prescribing is partly explained by the Pharmacy First scheme, a flagship policy of Rishi Sunak's government that allows patients to be prescribed antibiotics for common illnesses without seeing a GP, raising questions about whether the shift in prescribing patterns risks contributing to the rise in resistance.

"Antibiotic resistance is one of the greatest health threats we face," said the UKHSA's chief executive, Prof Susan Hopkins. "More people than ever are acquiring infections that cannot be effectively treated by antibiotics. This puts them at greater risk of serious illness and even death, with our poorest communities hit the hardest... It's positive that we've seen antibiotic use fall in England within the NHS but we need to go further, faster," said Hopkins.

"Please remember to only take antibiotics if you have been told to do so by a healthcare professional. Do not save some for later or share them with friends and family. If you have leftover antibiotics, please bring them to a pharmacy for appropriate disposal."

The dream of quantum computers has been hampered by the challenge of error correction, writes the Harvard Gazette, since qubits "are inherently susceptible to slipping out of their quantum states and losing their encoded information."

But in a newly-published paper, a research team "combined various methods to create complex circuits with dozens of error correction layers" that "suppresses errors below a critical threshold — the point where adding qubits further reduces errors rather than increasing them." "For the first time, we combined all essential elements for a scalable, error-corrected quantum computation in an integrated architecture," said Mikhail Lukin, co-director of the Quantum Science and Engineering Initiative, Joshua and Beth Friedman University Professor, and senior author of the new paper. "These experiments — by several measures the most advanced that have been done on any quantum platform to date — create the scientific foundation for practical large-scale quantum computation..."

"There are still a lot of technical challenges remaining to get to very large-scale computer with millions of qubits, but this is the first time we have an architecture that is conceptually scalable," said lead author Dolev Bluvstein, Ph.D. '25, who did the research during his graduate studies at Harvard and is now an assistant professor at Caltech. "It's going to take a lot of effort and technical development, but it's becoming clear that we can build fault-tolerant quantum computers...."

Hartmut Neven, vice president of engineering at the Google Quantum AI team, said the new paper came amid an "incredibly exciting" race between qubit platforms. "This work represents a significant advance toward our shared goal of building a large-scale, useful quantum computer," he said... With recent advances, Lukin believes the core elements for building quantum computers are falling into place. "This big dream that many of us had for several decades, for the first time, is really in direct sight," he said.
"In theory, a system of 300 quantum bits can store more information than the number of particles in the known universe..." the article points out.

"The new paper represents an important advance in a three-decade pursuit of quantum error correction."

Thanks to long-time Slashdot reader schwit1 for sharing the article.

alternative_right shares a report from ScienceAlert: A thorough investigation published in May 2023 found that the inner core of the Moon is, in fact, a solid ball with a density similar to that of iron. To figure it out once and for all, [astronomer Arthur Briaud of the French National Centre for Scientific Research in France] and his colleagues collected data from space missions and lunar laser-ranging experiments to compile a profile of various lunar characteristics. These include the degree of its deformation by its gravitational interaction with Earth, the variation in its distance from Earth, and its density.

... they found that the lunar core is very similar to that of Earth â" with an outer fluid layer and a solid inner core. According to their modeling, the outer core has a radius of about 362 kilometers (225 miles), and the inner core has a radius of about 258 kilometers (160 miles). That's about 15 percent of the entire radius of the Moon. The inner core, the team found, also has a density of about 7,822 kilograms per cubic meter. That's very close to the density of iron. [...] The research has been published in Nature.

One of the most common viruses in the world could be the cause of lupus, an autoimmune disease with wide-ranging symptoms, according to a new study. From a report: Until now, lupus was somewhat mysterious: No single root cause of the disease had been found, and while there is no cure, there are medications that can treat it.

The research, published in the journal Science Translational Medicine, suggests that Epstein-Barr virus -- which 95% of people acquire at some point in life -- could cause lupus by driving the body to attack its own healthy cells.

It adds to mounting evidence that Epstein-Barr is associated with multiple long-term health issues, including other autoimmune conditions. As this evidence stacks up, scientists have accelerated calls for a vaccine that targets the virus.

"If we now better understand how this fastidious virus is responsible for autoimmune diseases, I think it's time to figure out how to prevent it," said Dr. Anca Askanase, clinical director of the Lupus Center at Columbia University, who wasn't involved in the new research.

An anonymous reader quotes a report from TechCrunch: Jeff Bezos' Blue Origin has landed the booster of its New Glenn mega-rocket on a drone ship in the Atlantic Ocean on just its second attempt -- making it the second company to perform such a feat, following Elon Musk's SpaceX. It's an accomplishment that will help the new rocket system become an option to send larger payloads to space, the Moon, and beyond. Thursday's launch wasn't just about the landing attempt, though. Roughly 34 minutes after takeoff, the upper stage of New Glenn successfully deployed the rocket's first commercial payload: twin spacecraft for NASA that will travel to Mars to study the red planet's atmosphere. The pair of achievements are remarkable for the second-ever launch of such a massive rocket system. And it could put Blue Origin in position to compete with SpaceX, which dominates the world's launch market with its Falcon 9, Falcon Heavy, and Starship rockets. You can watch a recording of the launch here.

For the first time, astronomers captured the shockwave of a supernova bursting through the surface of a dying red supergiant star, revealing a surprisingly symmetrical, grape-shaped explosion. Space.com reports: Seeing this moment in detail has previously been elusive because it's rare for a supernova to be spotted early enough and for telescopes to be trained on it -- and when they have been, the exploding star has been too far away. So, when supernova 2024ggi went boom on April 10, 2024 in the relatively nearby spiral galaxy NGC 3621, which is 22 million light-years away in the constellation of Hydra, the Water Snake, astronomer Yi Yang of Tsinghua University in Beijing knew he had to act.

Although the supernova itself couldn't be resolved as anything put a point of light, the polarization of that light held the clues as to the geometry of the breakout. "The geometry of a supernova explosion provides fundamental information on stellar evolution and the physical processes leading to these cosmic fireworks," said Yang. "Spectropolarimetry delivers information about the geometry of the explosion that other types of observation cannot provide because the angular scales are too tiny," said another team-member, Lifan Wang of Texas A&M University.

The measurement showed that the shape of the breakout explosion was flattened, like an olive or grape. Crucially, though, the explosion propagated symmetrically, and continued to do so even when it collided with a ring of circumstellar material. "These findings suggest a common physical mechanism that drives the explosion of many massive stars, which manifests a well-defined axial symmetry and acts on large scales," said Yang. The findings will allow astronomers to rule out some models and strengthen others that describe what drives the shockwave in a supernova explosion. The findings have been described in a paper on the ESO website.

Animal testing in science would be phased out faster under a new plan to increase the use of artificial intelligence and 3D bioprinted human tissues, a UK minister has said. The Guardian: The roadmap unveiled by the science minister, Patrick Vallance, backs replacing certain animal tests that are still used where necessary to determine the safety of products such as life-saving vaccines and the impact pesticides have on living beings and the environment. The strategy says phasing out the use of animals in science can only happen when reliable and effective alternative methods with the same level of safety for human exposure can replace them.

The government said new funding for researchers and streamlined regulation would help develop methods such as organ-on-a-chip systems -- tiny devices that mimic how human organs work using real human cells. Greater use of AI to analyse vast amounts of data about molecules and predict whether new medicines will be safe and work well on humans would be deployed, while 3D bioprinted tissues could create realistic human tissue samples, from skin to liver, for testing.

Other plans under the strategy include an end to regulatory testing on animals to assess the potential for skin and eye irritation and skin sensitisation by the end of 2026. By 2027, researchers are expected under the strategy to end tests of the strength of botox on mice, while by 2030 pharmacokinetic studies -- which track how a drug moves through the body over time -- on dogs and non-human primates will be reduced.

The UK and China today signed a new bilateral agreement on scientific collaboration [non-paywalled source], narrowing the scope of their partnership to exclude sensitive technologies. Lord Patrick Vallance, Britain's science and technology minister, met his Chinese counterpart Chen Jiachang in Beijing and agreed to focus cooperation on health, climate, planetary sciences, and agriculture.

The previous agreement from 2017 had included satellites, remote sensing technology and robotics. Those fields are absent from the new accord. The countries announced no new funding for joint research. Vallance said the UK had "deliberately gone for areas which we think are not carrying such a security risk."

After more than a decade of planning, the launch of the African Medicines Agency (AMA) is being celebrated in Mombasa, Kenya, this week at the Seventh Biennial Scientific Conference on Medical Products Regulation in Africa. From a report: The agency's establishment marks a pivotal moment in Africa's public health, at a time when the need for biomedical research conducted in Africa, focused on African health problems, has never been greater. Africa holds higher levels of human genetic diversity than anywhere else on Earth, but this diversity has not been adequately studied. And many globally approved treatments and vaccines for diseases such as HIV/AIDS, malaria and tuberculosis are less effective, and can even be harmful in some people of African ancestry.

This year, cuts of billions of US dollars in international funding for biomedical research and health services in Africa have left millions of people without access to life-saving treatments or, in the case of researchers and health-care workers, unemployed. This demonstrates the immense vulnerability that comes with relying on funding from external donors.

What's more, Africa's phenomenal population growth and pace of urbanization is bringing fresh challenges -- as well as opportunities -- around health and disease. In Africa's cities today, the inhabitants of increasingly affluent neighbourhoods are demanding high-quality medicines and health care. But in low-income areas, high population density, inadequate housing and poor sanitation are facilitating the spread of respiratory and diarrhoeal infections. And everywhere, inadequate diets, air pollution, smoking and physical inactivity are driving increased rates of cardiovascular disease, diabetes and cancer. By 2100, Africa is expected to host 13 of the world's 20 largest cities, and such inequalities are likely to worsen.

Should we leave space exploration to robots — or prioritize human spaceflight, making us a multiplanetary species?

Harvard professor Robin Wordsworth, who's researched the evolution and habitability of terrestrial-type planets, shares his thoughts: In space, as on Earth, industrial structures degrade with time, and a truly sustainable life support system must have the capability to rebuild and recycle them. We've only partially solved this problem on Earth, which is why industrial civilization is currently causing serious environmental damage. There are no inherent physical limitations to life in the solar system beyond Earth — both elemental building blocks and energy from the sun are abundant — but technological society, which developed as an outgrowth of the biosphere, cannot yet exist independently of it. The challenge of building and maintaining robust life-support systems for humans beyond Earth is a key reason why a machine-dominated approach to space exploration is so appealing...

However, it's notable that machines in space have not yet accomplished a basic task that biology performs continuously on Earth: acquiring raw materials and utilizing them for self-repair and growth. To many, this critical distinction is what separates living from non-living systems... The most advanced designs for self-assembling robots today begin with small subcomponents that must be manufactured separately beforehand. Overall, industrial technology remains Earth-centric in many important ways. Supply chains for electronic components are long and complex, and many raw materials are hard to source off-world... If we view the future expansion of life into space in a similar way as the emergence of complex life on land in the Paleozoic era, we can predict that new forms will emerge, shaped by their changed environment, while many historical characteristics will be preserved. For machine technology in the near term, evolution in a more life-like direction seems likely, with greater focus on regenerative parts and recycling, as well as increasingly sophisticated self-assembly capabilities. The inherent cost of transporting material out of Earth's gravity well will provide a particularly strong incentive for this to happen.

If building space habitats is hard and machine technology is gradually developing more life-like capabilities, does this mean we humans might as well remain Earth-bound forever? This feels hard to accept because exploration is an intrinsic part of the human spirit... To me, the eventual extension of the entire biosphere beyond Earth, rather than either just robots or humans surrounded by mechanical life-support systems, seems like the most interesting and inspiring future possibility. Initially, this could take the form of enclosed habitats capable of supporting closed-loop ecosystems, on the moon, Mars or water-rich asteroids, in the mold of Biosphere 2. Habitats would be manufactured industrially or grown organically from locally available materials. Over time, technological advances and adaptation, whether natural or guided, would allow the spread of life to an increasingly wide range of locations in the solar system.
The article ponders the benefits (and the history) of both approaches — with some fasincating insights along the way.

"If genuine alien life is out there somewhere, we'll have a much better chance of comprehending it once we have direct experience of sustaining life beyond our home planet."

"For months, a small company in San Francisco has been pursuing a secretive project: the birth of a genetically engineered baby," reports the Wall Street Journal: Backed by OpenAI chief executive Sam Altman and his husband, along with Coinbase co-founder and CEO Brian Armstrong, the startup — called Preventive — has been quietly preparing what would amount to a biological first. They are working toward creating a child born from an embryo edited to prevent a hereditary disease.... Editing genes in embryos with the intention of creating babies from them is banned in the U.S. and many countries. Preventive has been searching for places to experiment where embryo editing is allowed, including the United Arab Emirates, according to correspondence reviewed by The Wall Street Journal...

Preventive is in the vanguard of a growing number of startups, funded by some of the most powerful people in Silicon Valley, that are pushing the boundaries of fertility and working to commercialize reproductive genetic technologies. Some are working on embryo editing, while others are already selling genetic screening tools that seek to account for the influence of dozens or hundreds of genes on a trait. They say their ultimate goal is to produce babies who are free of genetic disease and resilient against illnesses. Some say they can also give parents the ability to choose embryos that will have higher IQs and preferred traits such as height and eye color. Armstrong, the cryptocurrency billionaire, is leading the charge to make embryo editing a reality. He has told people that gene-editing technology could produce children who are less prone to heart disease, with lower cholesterol and stronger bones to prevent osteoporosis. According to documents and people briefed on his plans, he is already an investor or in talks with embryo editing ventures...

After the Journal approached people close to the company last month to ask about its work, Preventive announced on its website that it had raised $30 million in investment to explore embryo editing. The statement pledged not to advance to human trials "if safety cannot be established through extensive research..." Other embryo editing startups are Manhattan Genomics, co-founded by Thiel Fellow Cathy Tie, and Bootstrap Bio, which plans to conduct tests in Honduras. Both companies are in early stages.
The article notes the only known instance of children born from edited embryos was in 2018, when Chinese scientist He Jiankui "shocked the world with news that he had produced three children genetically altered as embryos to be immune to HIV. He was sentenced to prison in China for three years for the illegal practice of medicine.

"He hasn't publicly shared the children's identities but says they are healthy.

UPDATE (1:16 PST) Today's launch has been scrubbed due to weather, and Blue Origin is now reviewing opportunities for new launch windows.

Sunday Morning Blue Origin livestreamed the planned launch of its New Glenn rocket, which will carry a very unique mission for NASA. "Twin spacecraft are set to take off on an unprecedented, winding journey to Mars," reports CNN, "where they will investigate why the barren red planet began to lose its atmosphere billions of years ago." By observing two Mars locations simultaneously, this mission can measure how Mars responds to space weather in real time — and how the Martian magnetosphere changes... Called EscaPADE, the mission will aim for an orbital trajectory that has never been attempted before, according to aerospace company Advanced Space, which is supporting the project. If successful, it could be a crucial case study that can allow extraordinary flexibility for planetary science missions down the road. The robotic mission plans to spend a year idling in an orbital backroad before heading to its target destination... [R]ather than turning toward Mars, the two orbiters will instead aim for Lagrange Point 2, or L2 — a cosmic balance point about 1.5 million kilometers (930,000 miles) from Earth. Lagrange points are special because they act as gravitational wells in which the pull of the sun and Earth are in perfect balance. The conditions can allow spacecraft to linger without being dragged away... The spacecraft will then loop endlessly in a kidney bean-shaped orbit around L2 until next year's Mars transfer window opens.
This "launch and loiter" project is part of NASA's SIMPLEx [Small, Innovative Missions for Planetary Exploration] program, which seeks high-value missions for less money, notes CNN. "EscaPADE's cost was less than $100 million, compared with the roughly $300 million to $600 million price tags of other NASA satellites orbiting Mars."

"Blue Origin is also attempting to land and recover New Glenn's first-stage booster," notes another CNN article.

A CRISPR-based drug given to study participants by infusion is raising hopes for a much easier way to lower cholesterol, reports CNN: With a snip of a gene, doctors may one day permanently lower dangerously high cholesterol, possibly removing the need for medication, according to a new pilot study published Saturday in the New England Journal of Medicine.

The study was extremely small — only 15 patients with severe disease — and was meant to test the safety of a new medication delivered by CRISPR-Cas9, a biological sort of scissor which cuts a targeted gene to modify or turn it on or off. Preliminary results, however, showed nearly a 50% reduction in low-density lipoprotein, or LDL, the "bad" cholesterol which plays a major role in heart disease — the No.1 killer of adults in the United States and worldwide. The study, which will be presented Saturday at the American Heart Association Scientific Sessions in New Orleans, also found an average 55% reduction in triglycerides, a different type of fat in the blood that is also linked to an increased risk of cardiovascular disease.

"We hope this is a permanent solution, where younger people with severe disease can undergo a 'one and done' gene therapy and have reduced LDL and triglycerides for the rest of their lives," said senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio.... Today, cardiologists want people with existing heart disease or those born with a predisposition for hard-to-control cholesterol to lower their LDL well below 100, which is the average in the US, said Dr. Pradeep Natarajan, director of preventive cardiology at Massachusetts General Hospital and associate professor of medicine at Harvard Medical School in Boston...

People with a nonfunctioning ANGPTL3 gene — which Natarajan says applies to about 1 in 250 people in the US — have lifelong levels of low LDL cholesterol and triglycerides without any apparent negative consequences. They also have exceedingly low or no risk for cardiovascular disease. "It's a naturally occurring mutation that's protective against cardiovascular disease," said Nissen, who holds the Lewis and Patricia Dickey Chair in Cardiovascular Medicine at Cleveland Clinic. "And now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."
"Phase 2 clinical trials will begin soon, quickly followed by Phase 3 trials, which are designed to show the effect of the drug on a larger population, Nissen said."

And CNN quotes Nissen as saying "We hope to do all this by the end of next year. We're moving very fast because this is a huge unmet medical need — millions of people have these disorders and many of them are not on treatment or have stopped treatment for whatever reason."

The Associated Press reports that "For the past decade, Dr. Priscilla Chan and her husband Mark Zuckerberg have focused part of their philanthropy on a lofty goal — 'to cure, prevent or manage all disease' — if not in their lifetime, then in their children's."

During that decade they also funded other initiatives (including underprivileged schools and immigration reform), according to the article. But there's a change coming: Now, the billionaire couple is shifting the bulk of their philanthropic resources to Biohub, the pair's science organization, and focusing on using artificial intelligence to accelerate scientific discovery. The idea is to develop virtual, AI-based cell models to understand how they work in the human body, study inflammation and use AI to "harness the immune system" for disease detection, prevention and treatment. "I feel like the science work that we've done, the Biohub model in particular, has been the most impactful thing that we have done. So we want to really double down on that. Biohub is going to be the main focus of our philanthropy going forward," Zuckerberg said Wednesday evening at an event at the Biohub Imaging Institute in Redwood City, California.... Chan and Zuckerberg have pledged 99% of their lifetime wealth — from shares of Meta Platforms, where Zuckerberg is CEO — toward these efforts...

On Thursday, Chan and Zuckerberg also announced that Biohub has hired the team at EvolutionaryScale, an AI research lab that has created large-scale AI systems for the life sciences... Biohub's ambition for the next years and decades is to create virtual cell systems that would not have been possible without recent advances in AI. Similar to how large language models learn from vast databases of digital books, online writings and other media, its researchers and scientists are working toward building virtual systems that serve as digital representations of human physiology on all levels, such as molecular, cellular or genome. As it is open source — free and publicly available — scientists can then conduct virtual experiments on a scale not possible in physical laboratories.
"We will continue the model we've pioneered of bringing together scientists and engineers in our own state-of-the-art labs to build tools that advance the field," according to Thursday's blog post. "We'll then use those tools to generate new data sets for training new biological AI models to create virtual cells and immune systems and engineer our cells to detect and treat disease....

"We have also established the first large-scale GPU cluster for biological research, as well as the largest datasets around human cell types. This collection of resources does not exist anywhere else."

Unesco has adopted the first global ethical standards for neurotechnology, defining "neural data" and outlining more than 100 recommendations aimed at safeguarding mental privacy. "There is no control," said Unesco's chief of bioethics, Dafna Feinholz. "We have to inform the people about the risks, the potential benefits, the alternatives, so that people have the possibility to say 'I accept, or I don't accept.'" The Guardian reports: She said the new standards were driven by two recent developments in neurotechnology: artificial intelligence (AI), which offers vast possibilities in decoding brain data, and the proliferation of consumer-grade neurotech devices such as earbuds that claim to read brain activity and glasses that track eye movements.

The standards define a new category of data, "neural data," and suggest guidelines governing its protection. A list of more than 100 recommendations ranges from rights-based concerns to addressing scenarios that are -- at least for now -- science fiction, such as companies using neurotechnology to subliminally market to people during their dreams. "Neurotechnology has the potential to define the next frontier of human progress, but it is not without risks," said Unesco's director general, Audrey Azoulay. The new standards would "enshrine the inviolability of the human mind," she said.

An anonymous reader quotes a report from MIT Technology Review: Vanguard feels and smells like a new RV. It has long, gray banquettes that convert into bunks, a microwave cleverly hidden under a counter, a functional steel sink with a French press and crockery above. A weird little toilet hides behind a curtain. But some clues hint that you can't just fire up Vanguard's engine and roll off the lot. The least subtle is its door, a massive disc of steel complete with a wheel that spins to lock. Once it is sealed and moved to its permanent home beneath the waves of the Florida Keys National Marine Sanctuary early next year, Vanguard will be the world's first new subsea habitat in nearly four decades. Teams of four scientists will live and work on the seabed for a week at a time, entering and leaving the habitat as scuba divers. Their missions could include reef restoration, species surveys, underwater archaeology, or even astronaut training.

One of Vanguard's modules, unappetizingly named the "wet porch," has a permanent opening in the floor (a.k.a. a "moon pool") that doesn't flood because Vanguard's air pressure is matched to the water around it.It is this pressurization that makes the habitat so useful. Scuba divers working at its maximum operational depth of 50 meters would typically need to make a lengthy stop on their way back to the surface to avoid decompression sickness. This painful and potentially fatal condition, better known as the bends, develops if divers surface too quickly. A traditional 50-meter dive gives scuba divers only a handful of minutes on the seafloor, and they can make only a couple of such dives a day. With Vanguard's atmosphere at the same pressure as the water, its aquanauts need to decompress only once, at the end of their stay. They can potentially dive for many hours every day. That could unlock all kinds of new science and exploration.

ole_timer shares a report from the New York Times: James D. Watson, who entered the pantheon of science at age 25 when he joined in the discovery of the structure of DNA, one of the most momentous breakthroughs in the history of science, died on Thursday in East Northport, N.Y., on Long Island. He was 97. His death, in a hospice, was confirmed on Friday by his son Duncan, who said Dr. Watson was transferred to the hospice from a hospital this week after being treated there for an infection.

Dr. Watson's role in decoding DNA, the genetic blueprint for life, would have been enough to establish him as one of the most important scientists of the 20th century. But he cemented that fame by leading the ambitious Human Genome Project and writing perhaps the most celebrated memoir in science.