Math

Mathematical Proof Debunks the Idea That the Universe Is a Computer Simulation (phys.org) 248

alternative_right shares a report from Phys.org: Today's cutting-edge theory -- quantum gravity -- suggests that even space and time aren't fundamental. They emerge from something deeper: pure information. This information exists in what physicists call a Platonic realm -- a mathematical foundation more real than the physical universe we experience. It's from this realm that space and time themselves emerge. "The fundamental laws of physics cannot be contained within space and time, because they generate them. It has long been hoped, however, that a truly fundamental theory of everything could eventually describe all physical phenomena through computations grounded in these laws. Yet we have demonstrated that this is not possible. A complete and consistent description of reality requires something deeper -- a form of understanding known as non-algorithmic understanding." "We have demonstrated that it is impossible to describe all aspects of physical reality using a computational theory of quantum gravity," says Dr. Faizal. "Therefore, no physically complete and consistent theory of everything can be derived from computation alone. Rather, it requires a non-algorithmic understanding, which is more fundamental than the computational laws of quantum gravity and therefore more fundamental than spacetime itself."

"Drawing on mathematical theorems related to incompleteness and indefinability, we demonstrate that a fully consistent and complete description of reality cannot be achieved through computation alone," explains Dr. Mir Faizal, Adjunct Professor with UBC Okanagan's Irving K. Barber Faculty of Science. "It requires non-algorithmic understanding, which by definition is beyond algorithmic computation and therefore cannot be simulated. Hence, this universe cannot be a simulation."

The findings have been published in the Journal of Holography Applications in Physics.
United States

Obesity Rate Declining in U.S. (gallup.com) 138

Gallup: After peaking at a record high of 39.9% in 2022, the U.S. adult obesity rate has gradually declined to 37.0% in 2025. This is a statistically meaningful decrease representing an estimated 7.6 million fewer obese adults compared with three years ago. Meanwhile, diagnoses of diabetes -- a lifetime disease that can be managed but not cured -- have now reached an all-time high of 13.8%. Both metrics are part of the ongoing Gallup National Health and Well-Being Index.

[...] Over the past year, more Americans have turned to Type 2 antidiabetic GLP-1 drugs such as semaglutide (brand names Ozempic and Wegovy) for weight loss purposes. The percentage of adults who report taking this class of medicine specifically for weight loss has increased to 12.4%, compared with 5.8% in February 2024 when Gallup first measured it. Usage among women (15.2%) continues to outpace men (9.7%), but both groups have more than doubled their use in the past year. These results dovetail with increased awareness of the drugs used for weight loss, which has risen from 80% to 89% nationally in the same period.

Space

Alien Worlds May Be Able To Make Their Own Water (science.org) 16

sciencehabit shares a report from Science.org: From enabling life as we know it to greasing the geological machinery of plate tectonics, water can have a huge influence on a planet's behavior. But how do planets get their water? An infant world might be bombarded by icy comets and waterlogged asteroids, for instance, or it could form far enough from its host star that water can precipitate as ice. However, certain exoplanets pose a puzzle to astronomers: alien worlds that closely orbit their scorching home stars yet somehow appear to hold significant amounts of water.

A new series of laboratory experiments, published today in Nature, has revealed a deceptively straightforward solution to this enigma: These planets make their own water. Using diamond anvils and pulsed lasers, researchers managed to re-create the intense temperatures and pressures present at the boundary between these planets' hydrogen atmospheres and molten rocky cores. Water emerged as the minerals cooked within the hydrogen soup. Because this kind of geologic cauldron could theoretically boil and bubble for billions of years, the mechanism could even give hellishly hot planets bodies of water -- implying that ocean worlds, and the potentially habitable ones among them, may be more common than scientists already thought. "They can basically be their own water engines," says Quentin Williams, an experimental geochemist at the University of California Santa Cruz who was not involved with the new work.

Biotech

China Pushes Boundaries With Animal Testing to Win Global Biotech Race (bloomberg.com) 36

China is accelerating its biotech ambitions by pushing the limits of animal testing and gene editing (source paywalled; alternative source) while Western countries tighten ethical restrictions. "Editing the genes of large animals such as pigs, monkeys and dogs faces scant regulation in China," reports Bloomberg. "Meanwhile, regulators in the US and Europe demand layers of ethical reviews, rendering similar research involving large animals almost impossible." From the report: Backing the work of China's scientists is not only permissiveness but state money. In 2023 alone, the Chinese government funneled an estimated $3 billion into biotech. Its sales of cell and gene therapies are projected to reach $2 billion by 2033 from $300 million last year. On the Chinese researchers' side are government-supported breeding and research centers for gene-edited animals and a public largely in approval of pushing the boundaries of animal testing.

The country should become "a global scientific and technology power," Xi said, declaring biotechnology and gene editing a strategic priority. For decades, the country's pharmaceutical companies specialized in generics, reproducing drugs already pioneered elsewhere. Delving head first into gene editing research may be key to China's plan to develop innovative drugs as well as reduce its dependence on foreign pharmaceutical companies.

The result is a country that now dominates headlines with stories of large, genetically modified animals being produced for science -- and the catalog is startling. Its scientists have created monkeys with schizophrenia, autism and sleep disorders. They were the first to clone primates. They've engineered dogs with metabolic and neurological diseases, and even cloned a gene-edited beagle with a blood-clotting disorder.

Science

UK Cyclist Receives 3D-Printed Facial Prosthetic After Crash Left Him With Third-Degree Burns (theguardian.com) 9

A cyclist who received severe third-degree burns to his head after being struck by a drunk driver has been fitted with a printed 3D face. The Guardian: Dave Richards, 75, was given a 3D prosthetic by the NHS that fits the space on his face and mimics his hair colour, eye colour and skin. [...] While recovering, he was referred to reconstructive prosthetics, which has opened the Bristol 3D medical centre, the first of its kind in the UK to have 3D scanning, design and printing in a single NHS location. Richards, from Devon, said surgeons tried to save his eye but "they were worried any infection could spread from my eye down the optic nerve to the brain so the eye was removed."

[...] He called the process of getting a 3D-printed face "not the most pleasant." He added: "In the early days of my recovery, I felt very vulnerable, and would not expose myself to social situations. It took me a long time to feel comfortable about my image, how I thought people looked at me and what they thought of me -- but I have come a long way in that respect."

Math

First Shape Found That Can't Pass Through Itself (quantamagazine.org) 35

Mathematicians have identified the first shape that cannot pass through itself. Jakob Steininger and Sergey Yurkevich described the Noperthedron in a paper posted online in August. The shape has 90 vertices and 152 faces. The discovery resolves a question that began in the late 1600s when Prince Rupert of the Rhine won a bet by proving one cube could slide through a tunnel bored through another. Mathematician John Wallis confirmed this mathematically in 1693.

The property became known as the Rupert property. In 1968, Christoph Scriba proved the tetrahedron and octahedron also possess this quality. Over the past decade, researchers found Rupert tunnels through many symmetric polyhedra, including the dodecahedron and icosahedron. Mathematicians had conjectured every convex polyhedron would have the Rupert property. Steininger and Yurkevich divided the space of possible orientations into approximately 18 million blocks and tested each. None produced a passage. The Noperthedron consists of 150 triangles and two regular 15-sided polygons.
News

Finnish Fertility Rate Drops by a Third Since 2010 (npr.org) 176

Finland's fertility rate has dropped below 1.3 children per woman, the lowest among Nordic countries and far beneath the 2.1 replacement level needed to maintain a steady population. The rate has declined by a third since 2010. Kela, Finland's social insurance agency, started distributing 2025 "baby boxes" -- filled with clothing and other infant supplies -- in August instead of spring because so many 2024 boxes remained unclaimed.

More parents now choose cash payments over the traditional boxes filled with infant supplies. The decline puzzles researchers because Finland offers paid parental leave for both mothers and fathers, subsidized childcare and national healthcare. Anneli Miettinen, Kela's research manager, said that good family policies no longer explain birth rates in Nordic countries. Immigration has offset some population loss, but officials worry about workforce shrinkage and pension system strain.

Anna Rotkirch, who authored a government-commissioned report, found that many 17-year-olds describe wanting a house, garden, spouse and three children. Her research suggests young people struggle to form relationships, focus on education and careers, and delay childbearing. Some researchers attribute relationship difficulties to technology reducing physical interactions.
ISS

Japan Launches a New Cargo Spacecraft to ISS for the First Time (space.com) 10

"Japan's new HTV-X cargo spacecraft launched on its first-ever mission to the International Space Station on Saturday," reports Space.com: The robotic HTV-X lifted off atop an H3 rocket from Japan's Tanegashima Space Center at 8 p.m. EDT (0000 GMT and 9 a.m local Japan time on October 26). It is expected to arrive at the station for its capture and berthing on Wednesday (Oct. 29) at about 11:50 a.m. EDT (1550 GMT)...

The HTV-X's potential uses also extend beyond the ISS, according to JAXA. The agency envisions it aiding "post-ISS human space activities in low Earth orbit" as well as possibly flying cargo to Gateway, the space station NASA may build in lunar orbit as part of its Artemis program.

HTV-X's debut increases the stable of ISS cargo craft by one-third. The currently operational freighters are Russia's Progress vehicle and Cygnus and Dragon, spacecraft built by the American companies Northrop Grumman and SpaceX, respectively. Only Dragon is reusable; the others (including HTV-X) are designed to burn up in Earth's atmosphere when their missions are over.

China

China's Zhuque-3 Reusable Rocket Passes Key Milestone (universetoday.com) 42

China's private space company LandSpace has completed a key static fire test of its Zhuque-3 (ZQ-3) reusable rocket -- a stainless-steel, methane-fueled launcher modeled after SpaceX's Starship. Universe Today reports: The latest milestone took place on Monday, Oct. 22nd at the Dongfeng commercial space innovation pilot zone (where the JSLC is located). It involved another static fire test, where the rocket was fully-fueled but remained fixed to the launch pad while the engines were fired. This kind of testing is a crucial prelaunch trial (what NASA refers to as a "wet dress rehearsal"), and places the company and China another step closer to making an inaugural flight test, which is expected to happen by the fourth quarter of 2025.

In traditional Chinese, Zhuque is the name of the Vermillion Bird that represents fire, the south, and summer, and is one of the four Symbols of the Chinese constellations. Like the Starship, the Zhuque-3 is composed of stainless steel and relies on a combination of liquid methane (LCH4) and liquid oxygen (LOX) propellant. The rocket will be powered by nine Tianque-12A (TQ-12A) engines and will measure 65.9 m (216 ft) tall and weigh 550,000 kg (1,210,000 lb). It's payload capacity will be significantly less than the Starship: 11,800 kg (26,000 lbs) in its expendable mode, and 8,000 kg (18,000 lbs) for the recoverable version. This is closer in payload capacity to the Falcon 9, which is capable of delivering 22,800 kg (50,265 lbs) to Low Earth Orbit (LEO).

In time, the company hopes to transition to the larger Zhuque-3E, which will be 76.2 m (250 ft) tall and powered by nine TQ-12B engines, and will be capable of delivering to 21,000 kg (46,000 lb) in its expandable mode and 18,300 kg (40,300 lb) recoverable. The long term goal is to create a reusable system that can rival the Falcon rocket family, bringing the country closer to its goal of achieving parity with NASA.

The Military

Sweden's Crowd-Forecasting Platform 'Glimt' Helps Ukraine Make Wartime Predictions (france24.com) 20

alternative_right shares a report from France 24: [Sweden's] latest contribution to the war effort is Glimt, an innovative project launched by the Swedish Defence Research Agency (FOI) earlier this year. Glimt is an open platform that relies on the theory of "crowd forecasting": a method of making predictions based on surveying a large and diverse group of people and taking an average. "Glimt" is a Swedish word for "a glimpse" or "a sudden insight." The theory posits that the average of all collected predictions produces correct results with "uncanny accuracy," according to the Glimt website. Such "collective intelligence" is used today for everything from election results to extreme weather events, Glimt said. [...]

Group forecasting allows for a broad collection of information while avoiding the cognitive bias that often characterizes intelligence services. Each forecaster collects and analyses the available information differently to reach the most probable scenario and can add a short comment to explain their reasoning. The platform also encourages discussion between members so they can compare arguments and alter their positions. Available in Swedish, French and English, the platform currently has 20,000 registered users; each question attracts an average of 500 forecasters. Their predictions are later sent to statistical algorithms that cross-reference data, particularly the relevance of the answers they provided. The most reliable users will have a stronger influence on the results; this reinforces the reliability of collective intelligence.
"We used this method and research, and we suggested to the Ukrainians that it could improve their understanding of the world and its evolution," said Ivar Ekman, an analyst for the Swedish Defence Research Agency and program director for Glimt. "If you have a large group of people, you can achieve great accuracy in assessing future events. Research has shown that professional analysts don't necessarily have a better capacity in this domain than other people."
Earth

Study Reveals How Hard It Is To Avoid Pesticide Exposure (theguardian.com) 20

A study involving 641 participants across 10 European countries found pesticides in every silicone wristband worn for one week. Researchers at Radboud University tested for 193 pesticides and detected 173 substances. The average participant was exposed to 20 different pesticides through non-dietary sources. Non-organic farmers had the highest exposure at a median of 36 pesticides. Organic farmers and people living near farms recorded lower numbers.

Consumers living far from agricultural areas had a median of 17 pesticides. The wristbands captured banned substances including breakdown products of DDT, which was prohibited decades ago, and insecticides dieldrin and propoxur. Paul Scheepers, the molecular epidemiologist who co-authored the study, said people cannot avoid exposure to pesticides in their direct environment.
EU

Europe's Big Three Aerospace Manufacturers Combine Their Space Divisions (engadget.com) 34

Airbus, Leonardo, and Thales are merging their space divisions into a new France-based company that aims to create a "leading European player in space." The joint venture, expected to launch operations by 2027 pending regulatory approval, will pool R&D resources to accelerate satellite development and strengthen Europe's technological sovereignty in space. Engadget reports: The companies Airbus, Leonardo and Thales have finalized this deal. The new unnamed entity will be based in France and will employ around 25,000 people. Airbus will own 35 percent, while the other two companies will each own 32.5 percent. Executives are hoping this company will better serve Europe's need for "sovereignty" in space and help it create a rival to SpaceX's Starlink communications network. Increasing a presence in space is also seen as a good thing for security and defense.

This isn't just bluster. Thales and Airbus have long been rivals in the satellite market, but it looks like they are friends now. Leonardo is known for space systems and services. Combining all three could actually give SpaceX a run for its money, but we will have to wait and see. There are no planned site closures, as the companies say that each home country will keep its existing capabilities. This will be a standalone company, so think of it as an extremely well-financed startup. The first task for the upstart? Reporting indicates it'll be to find more efficient ways to develop and manufacture satellites.

First Person Shooters (Games)

Programmer Gets Doom Running On a Space Satellite (zdnet.com) 28

An Icelandic programmer successfully ran Doom on the European Space Agency's OPS-SAT satellite, proving that the iconic 1993 shooter can now run not just everywhere on Earth -- but in orbit. ZDNet reports: Olafur Waage, a senior software developer from Iceland who now works in Norway, explained at Ubuntu Summit 25.10 how he, a self-described "professional keyboard typist" and maker of funny videos, ended up making what is perhaps the game's most outlandish port yet: Doom running on a real satellite in orbit, the European Space Agency (ESA) OPS-SAT satellite. OPS-SAT, a "flying laboratory" for testing novel onboard computing techniques, was equipped with an experimental computer approximately 10 times more powerful than the norm for spacecraft. Waag explained, "OPS-SAT was the first of its kind, devoted to demonstrating drastically improved mission control capabilities when satellites can fly more powerful onboard computers. The point was to break the curse of being too risk-averse with multi-million-dollar spacecraft." (The satellite was decommissioned in 2024.) [...]

Running Doom in orbit was partly a challenge of portability and partly a challenge of the limitations of space hardware and mission control. The on-board ARM dual-core Cortex-A9 processor, while hot stuff for space computing hardware (which tends to be low-powered and radiation-hardened), was slow even by Earth-bound standards. Waage chose Chocolate Doom 2.3, a popular open-source version of Doom, for its compatibility with the Ubuntu 18.04 Long Term Support (LTS) distro, which was already running on OPS-SAT. Besides, Waage noted, "We picked Chocolate Doom 2.3 because of the libraries available for 18.04 -- that was the last one that would actually build.

Updating software in orbit is extremely difficult, so relatively little code would have to be uploaded. As Waage said, "Doom is relatively straightforward C with a few external dependencies." In other words, it's easy to port. [...] The only sign that Doom was running in space at first was a lone log entry. So, the team used the satellite's camera to snap real-time images of the Earth, then swapped Doom's Mars skybox for actual satellite photos. "The idea was to take a screenshot from the satellite and use that as the sky, all rendered in software using the game's restricted 256-color palette," explained Waage. Even this posed unexpected difficulties: "Trying to draw all of these beautiful colors with those colors," said Waage, "it's probably not going to work right off. But we tried gradient tests, NASA demo photos. It took quite a bit of tweaking." Eventually, instead of a fantasy Mars as the sky background, they got a good-looking, real Earth in the game's sky. The game itself ran flawlessly. After all, Waage said, "It ran beautifully. It's on Ubuntu."

Earth

Dinosaurs Were Thriving Until Asteroid Struck, Research Suggests (theguardian.com) 39

An anonymous reader quotes a report from The Guardian: Dinosaurs would not have become extinct had it not been for a catastrophic asteroid strike, researchers have said, challenging the idea the animals were already in decline. About 66 million years ago, during the late Cretaceous period, a huge space rock crashed into Earth, triggering a mass extinction that wiped out all dinosaurs except birds. However, some experts have argued the dinosaurs were already in decline. Now researchers say the dating of a rock formation in New Mexico throws doubt on that idea, suggesting dinosaurs were thriving until the fateful impact.

Dr Andrew Flynn, the first author of the research at New Mexico State University, said: "I think based on our new study that shows that, at least in North America, they weren't going towards extinction." Writing in the journal Science, Flynn and colleagues report how they dated a unit of rock called the Naashoibito Member in the San Juan basin using two methods. Flynn said the perception that overall dinosaur diversity was falling before the asteroid hit could be a result of there being fewer exposed rocks, and hence fossils, dating to the end of the Cretaceous period than earlier in the epoch. "It looks like, as far as we can tell, there's no reason they should have gone extinct except for [the] asteroid impact," he said.

Google

Google's Quantum Computer Makes a Big Technical Leap (nytimes.com) 30

Google announced Wednesday that its quantum computer achieved the first verifiable quantum advantage, running a new algorithm 13,000 times faster than a top supercomputer. The algorithm, called Quantum Echoes, was published in the journal Nature. The results can be replicated on another quantum computer of similar quality, something Google had not demonstrated before. The quantum computer uses a chip called Willow, which was announced in December 2024. Hartmut Neven, head of Google's Quantum AI research lab, called the work a demonstration of the first algorithm with verifiable quantum advantage and a milestone on the software track.

Michel H. Devoret, who won this year's Nobel Prize in Physics and joined Google in 2023, said future quantum computers will run calculations impossible with classical algorithms. Google stopped short of claiming the work would have practical uses on its own. Instead, the company said Quantum Echoes demonstrated a technique that could be applied to other algorithms in drug discovery and materials science.

A second paper published Wednesday on arXiv showed how the method could be applied to nuclear magnetic resonance. The experiment involved a relatively small quantum system that fell short of full practical quantum advantage because it was not able to work faster than a traditional computer. Google exhaustively red-teamed the research, putting some researchers to work trying to disprove its own results.

Prineha Narang, a professor at UCLA, called the advance meaningful. The quantum computer tested two molecules, one with 15 atoms and another with 28 atoms. Results on the quantum computer matched traditional NMR and revealed information not usually available from NMR. Google's research competes against Microsoft, IBM, universities and efforts in China. The Chinese government has committed more than $15.2 billion to quantum research. Previous claims of quantum advantage have been met with skepticism.
Medicine

Resistant Bacteria Are Advancing Faster Than Antibiotics (wired.com) 59

The proliferation of difficult-to-treat bacterial diseases represents a growing threat, according to the World Health Organization's (WHO) Global Antibiotic Resistance Surveillance Report. Wired: The report reveals that, between 2018 and 2023, antibiotic resistance increased by more than 40 percent in monitored pathogen-drug combinations, with an average annual increase of 5-15 percent. According to data reported by more than 100 countries to WHO's Global Antimicrobial Resistance and Use Surveillance System (GLASS), one in six laboratory-confirmed bacteria in 2023 proved resistant to antibiotic treatment, all related to various common diseases globally.

For the first time, this edition of the report includes prevalence estimates of resistance to 22 antibiotics used to treat urinary tract, gastrointestinal, bloodstream, and gonorrheal conditions. The analysis focused on eight common pathogens: Acinetobacter spp, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, non-typhoidal Salmonella spp, Shigella spp, Staphylococcus aureus, and Streptococcus pneumoniae. The results show that resistant gram-negative bacteria pose the greatest threat. Of particular note are Escherichia coli and Klebsiella pneumoniae, which are associated with bloodstream infections that can lead to sepsis, organ failure, and death. "More than 40 percent of E. coli and more than 55 percent of K. pneumoniae strains worldwide are now resistant to third-generation cephalosporins, the first-choice treatment for these types of infections," the report warns.

NASA

NASA Opens SpaceX's Moon Lander Contract To Rivals Over Starship Delays (reuters.com) 61

NASA has reopened SpaceX's $4.4 billion moon lander contract to new bidders like Blue Origin and Lockheed Martin after delays in Starship's development threatened the 2027 Artemis 3 mission. Reuters reports: The move paves the way for rivals such as Jeff Bezos' Blue Origin to snatch a high-profile mission to land the first astronauts on the moon in half a century. "I'm in the process of opening that contract up. I think we'll see companies like Blue get involved, and maybe others," the U.S. space agency's acting chief Sean Duffy, who also serves as U.S. Transportation Secretary, told Fox News' "Fox & Friends" program.

Duffy's comments follow months of mounting pressure within NASA to speed up its Artemis lunar program and push SpaceX to make greater progress on its Starship lunar lander, while China progresses toward its own goal of sending humans to the moon by 2030. It represents a major shift in NASA's lunar strategy, starting a new competitive juncture in the program for a crewed moon lander just two years before the scheduled landing date. Blue Origin is widely expected to compete for the mission, while Lockheed Martin has indicated it would convene an industry team to heed NASA's call.

Starship, picked by NASA in 2021 under a contract now worth $4.4 billion, faces a 2027 moon landing deadline that agency advisers estimate could slip years behind schedule, citing competing priorities. Musk sees Starship as crucial to launching larger batches of Starlink satellites to space and eventually ferrying humans to Mars, among other missions. "They do remarkable things, but they're behind schedule," Duffy said of SpaceX's lunar lander work, adding President Donald Trump wants to see the mission take place before his White House term ends in January 2029.

Space

Mystery Object From 'Space' Strikes United Airlines Flight Over Utah (wired.com) 58

UPDATE: It may have been a weather balloon...

An anonymous reader quotes a report from Wired: The National Transportation Safety Board confirmed Sunday that it is investigating an airliner that was struck by an object in its windscreen, mid-flight, over Utah. "NTSB gathering radar, weather, flight recorder data," the federal agency said on the social media site X. "Windscreen being sent to NTSB laboratories for examination." The strike occurred Thursday, during a United Airlines flight from Denver to Los Angeles. Images shared on social media showed that one of the two large windows at the front of a 737 MAX aircraft was significantly cracked. Related images also reveal a pilot's arm that has been cut multiple times by what appear to be small shards of glass.

The captain of the flight reportedly described the object that hit the plane as "space debris." This has not been confirmed, however. After the impact, the aircraft safely landed at Salt Lake City International Airport after being diverted. Images of the strike showed that an object made a forceful impact near the upper-right part of the window, showing damage to the metal frame. Because aircraft windows are multiple layers thick, with laminate in between, the window pane did not shatter completely. The aircraft was flying above 30,000 feet -- likely around 36,000 feet -- and the cockpit apparently maintained its cabin pressure.

AI

OpenAI's 'Embarrassing' Math (techcrunch.com) 41

An anonymous reader writes: "Hoisted by their own GPTards." That's how Meta's Chief AI Scientist Yann LeCun described the blowback after OpenAI researchers did a victory lap over GPT-5's supposed math breakthroughs. Google DeepMind CEO Demis Hassabis added, "this is embarrassing." The Decoder reports that in a since-deleted tweet, OpenAI VP Kevin Weil declared that "GPT-5 found solutions to 10 (!) previously unsolved Erdos problems and made progress on 11 others." ("Erdos problems" are famous conjectures posed by mathematician Paul Erdos.)

However, mathematician Thomas Bloom, who maintains the Erdos Problems website, said Weil's post was "a dramatic misrepresentation" -- while these problems were indeed listed as "open" on Bloom's website, he said that only means, "I personally am unaware of a paper which solves it." In other words, it's not accurate to claim GPT-5 was able to solve previously unsolved problems. Instead, Bloom wrote, "GPT-5 found references, which solved these problems, that I personally was unaware of."

Science

Experts Hail 'Remarkable' Success of Electronic Implant in Restoring Sight (theguardian.com) 18

An electronic eye implant has restored reading ability to patients blinded by geographic atrophy, a form of dry age-related macular degeneration. Results published Monday in the New England Journal of Medicine showed that 84% of trial participants regained the ability to read letters, numbers, and words after receiving the Prima device.

The microchip measures two millimetres by two millimetres and is implanted beneath the center of the retina. Patients wear augmented reality glasses containing a camera that projects images onto the chip. The device converts light into electrical pulses transmitted to the brain.

Frank Holz, the study's lead author and chair of ophthalmology at the University Hospital of Bonn, called the implant "a paradigm shift in treating late-stage age-related macular degeneration." Mahi Muqit, a consultant at Moorfields Eye Hospital in London, said the trial enabled "meaningful central vision restoration, which has never been done before." The procedure takes less than two hours and requires intensive rehabilitation. Science Corporation, which manufactures the device, has applied for clinical authorization in the United States and Europe.
Medicine

Peanut Allergies Have Plummeted in Children, Study Shows (nytimes.com) 89

Food allergies in children dropped sharply in the years after new guidelines encouraged parents to introduce infants to peanuts, a study has found. The New York Times: For decades, as food allergy rates climbed, experts recommended that parents avoid exposing their infants to common allergens. But a landmark trial in 2015 found that feeding peanuts to babies could cut their chances of developing an allergy by over 80%. [non-paywalled source.] In 2017, the National Institute of Allergy and Infectious Diseases formally recommended the early-introduction approach and issued national guidelines.

The new study, published Monday in the journal Pediatrics, found that food allergy rates in children under 3 fell after those guidelines were put into place -- dropping to 0.93% between 2017 and 2020, from 1.46% between 2012 and 2015. That's a 36% reduction in all food allergies, driven largely by a 43% drop in peanut allergies. The study also found that eggs overtook peanuts as the No. 1 food allergen in young children.

The study did not examine what infants ate, so it does not show that the guidelines caused the decline. Still, the data is promising. While all food allergies can be dangerous, 80% of people never outgrow one.

Science

Are We Living in a Golden Age of Stupidity? (theguardian.com) 191

Test scores across OECD countries peaked around 2012 and have declined since. IQ scores in many developed countries appear to be falling after rising throughout the twentieth century. Nataliya Kosmyna at MIT's Media Lab began noticing changes around two years ago when strangers started emailing her to ask if using ChatGPT could alter their brains. She posted a study in June tracking brain activity in 54 students writing essays. Those using ChatGPT showed significantly less activity in networks tied to cognitive processing and attention compared to students who wrote without digital help or used only internet search engines. Almost none could recall what they had written immediately after submitting their work.

She received more than 4,000 emails afterward. Many came from teachers who reported students producing passable assignments without understanding the material. A British survey found that 92% of university students now use AI and roughly 20% have used it to write all or part of an assignment. Independent research has found that more screen time in schools correlates with worse results. Technology companies have designed products to be frictionless, removing the cognitive challenges brains need to learn. AI now allows users to outsource thinking itself.
Biotech

Should We Edit Nature to Help It Survive Climate Change? (noemamag.com) 75

A recent article in Noema magazines explores the issues in "editing nature to fix our failures."

"It turns out playing God is neither difficult nor expensive," the article points out. "For about $2,000, I can go online and order a decent microscope, a precision injection rig, and a vial of enough CRISPR-Cas9 — an enzyme-based genome-editing tool — to genetically edit a few thousand fish embryos..." So when going beyond the kept-in-captivity Dire Wolf to the possibility of bringing back forests of the American chestnut tree, "The process is deceptively simple; the implications are anything but..." If scientists could use CRISPR to engineer a more heat-tolerant coral, it would give coral a better chance of surviving a marine environment made warmer by climate change. It would also keep the human industries that rely on reefs afloat. But should we edit nature to fix our failures? And if we do, is it still natural...? Evolution is not keeping pace with climate change, so it is up to us to give it an assist [according to Christopher Preston, an environmental philosopher from the University of Montana, who wrote a book on CRISPR called "Ma href="https://mitpress.mit.edu/9780262537094/the-synthetic-age/">The Synthetic Age."] In some cases, the urgency is so great that we may not have time to waste. "There's no doubt there are times when you have to act," Preston continued. "Corals are a case where the benefits of reefs are just so enormous that keeping some alive, even if they're genetically altered, makes the risks worth it."
Kate Quigley, a molecular ecologist and a principal research scientist at Australia's Minderoo Foundation, says "Engineering the ocean, or the atmosphere, or coral is not something to be taken lightly. Science is incredible. But that doesn't mean we know everything and what the unintended consequences might be." Phillip Cleves, a principal investigator at the Carnegie Institute for Science's embryology department, is already researching whether coral could be bioengineered to be more tolerant to heat.

But both of them have concerns: For all the research Quigley and Cleves have dedicated to climate-proofing coral, neither wants to see the results of their work move from experimentation in the lab to actual use in the open ocean. Needing to do so would represent an even greater failure by humankind to protect the environment that we already have. And while genetic editing and selective breeding offer concrete solutions for helping some organisms adapt, they will never be powerful enough to replace everything lost to rising water temperatures. "I will try to prepare for it, but the most important thing we can do to save coral is take strong action on climate change," Quigley told me. "We could pour billions and billions of dollars — in fact, we already have — into restoration, and even if, by some miracle, we manage to recreate the reef, there'd be other ecosystems that would need the same thing. So why can't we just get at the root issue?"
And then there's the blue-green algae dilemma: George Church, the Harvard Medical School professor of genetics behind Colossal's dire wolf project, was part of a team that successfully used CRISPR to change the genome of blue-green algae so that it could absorb up to 20% more carbon dioxide via photosynthesis. Silicon Valley tech incubator Y Combinator seized on the advance to call for scaled-up proposals, estimating that seeding less than 1% of the ocean's surface with genetically engineered phytoplankton would sequester approximately 47 gigatons of CO2 a year, more than enough to reverse all of last year's worldwide emissions.

But moving from deploying CRISPR for species protection to providing a planetary service flips the ethical calculus. Restoring a chestnut forest or a coral reef preserves nature, or at least something close to it. Genetically manipulating phytoplankton and plants to clean up after our mistakes raises the risk of a moral hazard. Do we have the right to rewrite nature so we can perpetuate our nature-killing ways?

Science

Protein Powders and Shakes Contain High Levels of Lead (consumerreports.org) 122

Long-time Slashdot reader fjo3 shares an announcement from the U.S.-based nonprofit Consumer Reports: Protein powders still carry troubling levels of toxic heavy metals, according to a new Consumer Reports (CR) investigation. Our latest tests of 23 protein powders and ready-to-drink shakes from popular brands found that heavy metal contamination has become even more common among protein products, raising concerns that the risks are growing right alongside the industry itself. For more than two-thirds of the products we analyzed, a single serving contained more lead than CR's food safety experts say is safe to consume in a day — some by more than 10 times...

[I]n addition to the average level of lead being higher than what we found 15 years ago, there were also fewer products with undetectable amounts of it. The outliers also packed a heavier punch. Naked Nutrition's Vegan Mass Gainer powder, the product with the highest lead levels, had nearly twice as much lead per serving as the worst product we analyzed in 2010. Nearly all the plant-based products CR tested had elevated lead levels, but some were particularly concerning. Two had so much lead that CR's experts caution against using them at all... Dairy-based protein powders and shakes generally had the lowest amounts of lead, but half of the products we tested still had high enough levels of contamination that CR's experts advise against daily use...

Unlike prescription and over-the-counter drugs, the Food and Drug Administration doesn't review, approve, or test supplements like protein powders before they are sold. Federal regulations also don't generally require supplement makers to prove their products are safe, and there are no federal limits for the amount of heavy metals they can contain.

The article acknowledges that "Many of these powders are fine to have occasionally, and even those with the highest lead levels are far below the concentration needed to cause immediate harm. That said, because most people don't actually need protein supplements — nutrition experts say the average American already gets plenty — it makes sense to ask whether these products are worth the added exposure."
Biotech

Should Scientists Be Allowed to Edit Genes of Wild Animals? Top Conservation Groups Just Voted Yes (nbcnews.com) 26

It's the world's largest network of environmental groups, according to NBC News, with more than 1,400 members from roughly 160 countries. It meets once every four years.

And in a vote Tuesday, the International Union for Conservation of Nature "approved further exploration of the use of genetic engineering tools to aid in the preservation of animal species and other living organisms." Researchers are already pursuing projects that involve changing some species' DNA. Scientists are genetically modifying mosquitoes to reduce transmission of diseases like malaria, for example, and synthesizing horseshoe crab blood, which is used in drug development. Controversial efforts to "de-extinct" archaic creatures — such as the so-called "dire wolf" that a biosciences company announced it had revived this spring — fall under the umbrella, as well. So do possibilities like modifying organisms to help them adapt to a warming world, which are on the table but further off in development.... The decision is applicable to work on a range of organisms, including animals, plants, yeasts and bacteria....

The notion of introducing genetic engineering into wild ecosystems would have been considered a nonstarter in most conservation circles a decade ago, according to Jessica Owley [a professor and environment law program director at the University of Miami]. But the intensifying effects of climate change and other stressors to biodiversity are bolstering arguments in favor of human intervention that could make endangered species resistant to those threats... The IUCN vote, she added, reflects a feeling of desperation among conservationists and governments, as existing regulations and conservation efforts fall short and species continue to disappear worldwide.

"A separate measure, a proposed moratorium on releasing genetically modified organisms into the environment, failed by a single vote..."
Space

'How We Sharpened the James Webb Telescope's Vision From a Million Kilometers Away' (theconversation.com) 18

The James Webb Space Telescope gets its highest resolution with the aperture masking interferometer (or AMI), "a tiny piece of precisely machined metal that slots into one of the telescope's cameras," according to a new article by Benjamin Pope, an associated math professor at Macquarie University.

"We can finally present its first successful observations of stars, planets, moons and even black hole jets." [AMI] was put on Webb to diagnose and measure any blur in its images. Even nanometres of distortion in Webb's 18 hexagonal primary mirrors and many internal surfaces will blur the images enough to hinder the study of planets or black holes, where sensitivity and resolution are key. AMI filters the light with a carefully structured pattern of holes in a simple metal plate, to make it much easier to tell if there are any optical misalignments. We wanted to use this mode to observe the birth places of planets, as well as material being sucked into black holes. But before any of this, AMI showed Webb wasn't working entirely as hoped.

At very fine resolution — at the level of individual pixels — all the images were slightly blurry due to an electronic effect: brighter pixels leaking into their darker neighbours. This is not a mistake or flaw, but a fundamental feature of infrared cameras that turned out to be unexpectedly serious for Webb. This was a dealbreaker for seeing distant planets many thousands of times fainter than their stars a few pixels away: my colleagues quickly showed that its limits were more than ten times worse than hoped. So, we set out to correct it...

We built a computer model to simulate AMI's optical physics, with flexibility about the shapes of the mirrors and apertures and about the colours of the stars. We connected this to a machine learning model to represent the electronics with an "effective detector model" — where we only care about how well it can reproduce the data, not about why. After training and validation on some test stars, this setup allowed us to calculate and undo the blur in other data, restoring AMI to full function. It doesn't change what Webb does in space, but rather corrects the data during processing. It worked beautifully — the star HD 206893 hosts a faint planet and the reddest-known brown dwarf (an object between a star and a planet). They were known but out of reach with Webb before applying this correction. Now, both little dots popped out clearly in our new maps of the system... With the new correction, we brought Jupiter's moon Io into focus, clearly tracking its volcanoes as it rotates over an hour-long timelapse.

"This correction has opened the door to using AMI to prospect for unknown planets at previously impossible resolutions and sensitivities..." the article points out.

"Our results on painstakingly testing and enhancing AMI are now released on the open-access archive arXiv in a pair of papers."

Thanks to long-time Slashdot reader schwit1 for sharing the article.
Science

Physicists Inadvertently Generated the Shortest X-Ray Pulses Ever Observed (theconversation.com) 18

Physicists using SLAC's X-ray free-electron laser discovered two new laser phenomena that allowed them to generate the shortest, highest-energy X-ray pulses ever recorded (60-100 attoseconds). These breakthroughs could let scientists observe electron motion and chemical bond formation in real time. Physicists Uwe Bergmann and Thomas Linker write in an article for The Conversation: In this new study we used X-rays, which have 100 million times shorter wavelengths than microwaves and 100 million times more energy. This meant the resulting new X-ray laser pulses were split into different X-ray wavelengths corresponding to Rabi frequencies in the extreme ultraviolet region. Ultraviolet light has a frequency 100 million times higher than radio waves. This Rabi cycling effect allowed us to generate the shortest high-energy X-ray pulses to date, clocking in at 60-100 attoseconds.

While the pulses that X-ray free-electron lasers currently generate allow researchers to observe atomic bonds forming, rearranging and breaking, they are not fast enough to look inside the electron cloud that generates such bonds. Using these new attosecond X-ray laser pulses could allow scientists to study the fastest processes in materials at the atomic-length scale and to discern different elements.

In the future, we also hope to use much shorter X-ray free-electron laser pulses to better generate these attosecond X-ray pulses. We are even hoping to generate pulses below 60 attoseconds by using heavier materials with shorter lifespans, such as tungsten or hafnium. These new X-ray pulses are fast enough to eventually enable scientists to answer questions such as how exactly an electron cloud moves around and what a chemical bond actually is.
The findings have been published in the journal Nature.
Science

Scientists Create New Form of Ice, Known As Ice XXI (popularmechanics.com) 75

fahrbot-bot shares a report from Popular Mechanics: [I]n a new study published in the journal Nature Materials, scientists from the Korea Research Institute of Standards and Science (KRISS) have now found yet another phase, appropriately named Ice XXI. At the heart of the experiment, scientists used diamond anvil cells (DACs) -- a common device used in materials science for squeezing samples under immense pressure -- to subject water to 2 gigapascals (20,000 times higher than normal atmosphere) of pressure in just 10 milliseconds.

The scientists call this kind of water "supercompressed," and it's metastable, meaning it persists for a time even when another form of ice would be more stable. And because of the immense pressure, ice forms at room temperature but the molecules are much more densely packed. "Rapid compression of water allows it to remain liquid up to higher pressures, where it should have already crystallized to ice VI," Geun Woo Lee, a co-author of the study from RISS, said in a press statement. "The structure in which liquid H2O crystallizes depends on the degree of supercompression of the liquid."

Medicine

New Alzheimer's Treatment Clears Plaques From Brains of Mice Within Hours 53

Scientists from Spain and China have successfully repaired the blood-brain barrier in Alzheimer's-model mice, enabling the brain to naturally clear amyloid-beta plaques and reverse cognitive decline. "After just three drug injections, mice with certain genes that mimic Alzheimer's showed a reversal of several key pathological features," adds ScienceAlert. From the report: Within hours of the first injection, the animal brains showed a nearly 45 percent reduction in clumps of amyloid-beta plaques, a hallmark of Alzheimer's disease. The mice had previously shown signs of cognitive decline, but after all three doses, the animals performed on par with their healthy peers in spatial learning and memory tasks. The benefits lasted at least six months.

These preclinical results don't guarantee success in humans, but they're an encouraging start, which the authors say "heralds a new era" in drug research. "The therapeutic implications are profound," claim the international team of researchers, co-led by scientists at the Institute for Bioengineering of Catalonia (IBEC) and the West China Hospital Sichuan University (WCHSU).
The findings have been published in Signal Transduction and Targeted Therapy.
Medicine

Focused Sound Energy Holds Promise For Treating Cancer, Alzheimer's and Other Diseases (theconversation.com) 11

An anonymous reader quotes a report from the Conversation: Sound waves at frequencies above the threshold for human hearing are routinely used in medical care. Also known as ultrasound, these sound waves can help clinicians diagnose and monitor disease, and can also provide first glimpses of your newest family members. And now, patients with conditions ranging from cancer to neurodegenerative diseases like Alzheimer's may soon benefit from recent advances in this technology.

I am a biomedical engineer who studies how focused ultrasound -- the concentration of sound energy into a specific volume -- can be fine-tuned to treat various conditions. Over the past few years, this technology has seen significant growth and use in the clinic. And researchers continue to discover new ways to use focused ultrasound to treat disease. [...] Research on focused ultrasound has primarily focused on the most devastating and prevalent diseases, such as cancer and Alzheimer's disease. However, I believe that further developments in, and increased use of, focused ultrasound in the clinic will eventually benefit patients with rare diseases.

One rare disease of particular interest for my lab is cerebral cavernous malformation, or CCM. CCMs are lesions in the brain that occur when the cells that make up blood vessels undergo uncontrolled growth. While uncommon, when these lesions grow and hemorrhage, they can cause debilitating neurological symptoms. The most common treatment for CCM is surgical removal of the brain lesions; however, some CCMs are located in brain areas that are difficult to access, creating a risk of side effects. Radiation is another treatment option, but it, too, can lead to serious adverse effects.

We found that using focused ultrasound to open the blood-brain barrier can improve drug delivery to CCMs. Additionally, we also observed that focused ultrasound treatment itself could stop CCMs from growing in mice, even without administering a drug. While we don't yet understand how focused ultrasound is stabilizing CCMs, abundant research on the safety of using this technique in patients treated for other conditions has allowed neurosurgeons to begin designing clinical trials testing the use of this technique on people with CCM. With further research and advancements, I am hopeful that focused ultrasound can become a viable treatment option for many devastating rare diseases.

Math

The Numbers Six and Seven Are Making Life Hell for Math Teachers (msn.com) 165

Math teachers across American schools are contending with a classroom disruption that has proven impossible to contain. The numbers six and seven now trigger instant pandemonium among students. They scream the phrase and perform a palms-up seesaw hand gesture whenever the numbers appear in equations or instructions.

Teachers have begun avoiding breaking students into groups of six or seven or asking them to turn to page 67. The meme has no meaning, reports WSJ. That absence of meaning is the point. The phenomenon traces back to late last year when Philadelphia rapper Skrilla released "Doot Doot (6 7)," a song referencing 67th street where his friends grew up. The phrase spiraled into youth culture in March through a viral video of a boy with forward-swept hair lurching toward a camera to deliver an animated "six seven." Skrilla is now touring venues where audiences wait for the six-seven line. Some teachers have attempted to neutralize the meme by saying it themselves.
Mars

Common Yeast Can Survive Martian Conditions (phys.org) 33

A new study shows that common baker's yeast (Saccharomyces cerevisiae) can survive Mars-like conditions, including meteorite shock waves and toxic perchlorate salts found in Martian soil. Phys.org reports: Published in PNAS Nexus, Purusharth I. Rajyaguru and colleagues subjected Saccharomyces cerevisiae, which is a widely used model yeast, to shock waves and perchlorates. The authors chose the yeast in part because it has already been studied in space. When stressed, yeast, humans, and many other organisms form ribonucleoprotein (RNP) condensates, structures made of RNA and proteins that protect RNA and affect the fates of mRNAs. When the stressor passes, the RNP condensates, which include subtypes known as stress granules and P-bodies, disassemble.

The authors simulated Martian shock waves at the High-Intensity Shock Tube for Astrochemistry (HISTA) housed in the Physical Research Laboratory in Ahmedabad, India. Yeast exposed to 5.6 Mach intensity shock waves survived with slowed growth, as did yeast subjected to 100 mM sodium salt of perchlorate (NaClO4) -- a concentration similar to that in Martian soils. Yeast cells also survived exposure to the combined stress of shock waves and perchlorate stress. In both cases, the yeast assembled RNP condensates. Shock waves induced the assembly of stress granules and P-bodies; perchlorate caused yeast to make P-bodies but not stress granules. Mutants incapable of assembling RNP condensates were poor at surviving the Martian stress condition. Transcriptome analysis identified specific RNA transcripts perturbed by Mars-like conditions.

Communications

Satellites Are Leaking the World's Secrets: Calls, Texts, Military and Corporate Data (wired.com) 21

Researchers at UC San Diego and the University of Maryland have found that roughly half of geostationary satellite signals transmit sensitive data without encryption. The team spent three years using an $800 satellite receiver on a university rooftop in San Diego to intercept communications from satellites visible from their location. They collected phone calls and text messages from more than 2,700 T-Mobile users in just nine hours of recording.

The researchers also obtained data from airline passengers using in-flight Wi-Fi, communications from electric utilities and offshore oil and gas platforms, and US and Mexican military communications that revealed personnel locations and equipment details. The exposed data resulted from telecommunications companies using satellites to relay signals from remote cell towers to their core networks.

The researchers examined only about 15% of global satellite transponder communications and presented their findings at an Association for Computing Machinery conference in Taiwan this week. Most companies warned by the researchers have encrypted their satellite transmissions, but some US critical infrastructure owners have not yet added encryption.
NASA

NASA Unit JPL To Lay Off About 550 Workers, Citing Restructure (cnbc.com) 60

NASA's Jet Propulsion Laboratory is laying off around 550 employees, or roughly 11% of its workforce, as part of an effort to "restructure and establish an appropriate size to ensure future success." According to JPL Director Dave Gallagher, the job cuts "are not related to the current government shutdown." CNBC reports: JPL is a research and development lab funded by NASA -- the federal space agency -- and managed by the California Institute of Technology. "While not easy, I believe that taking these actions now will help the Lab transform at the scale and pace necessary to help achieve humanity's boldest ambitions in space," Gallagher wrote in a separate mekor to JPL employees and contractors. Gallagher, in the public announcement, noted that the reorganization of JPL began in July, and "over the past few months, we have communicated openly with employees about the challenges and hard choices ahead."

"This week's action, while not easy, is essential to securing JPL's future by creating a leaner infrastructure, focusing on our core technical capabilities, maintaining fiscal discipline, and positioning us to compete in the evolving space ecosystem -- all while continuing to deliver on our vital work for NASA and the nation," Gallagher wrote. Gallagher said that JPL employees will be notified of their status on Tuesday, and the "new Lab structure ... will become effective Wednesday."

Space

SpaceX Starship Hits Key Milestones Before Stunning Splashdown (cnn.com) 166

SpaceX's Starship megarocket successfully completed its 11th test flight, achieving major milestones like engine relight, satellite deployment, and a controlled splashdown in the Indian Ocean. From a report: This mission marks the second clean test run for Version 2, following a successful showing during its last test mission in August. Earlier this year, however, Starship Version 2 suffered three in-flight failures and an explosive accident during ground testing. Today's test mission is expected to be the last for the current iteration of Starship prototypes. The company has said it will debut a scaled up Version 3 for the next flight. You can watch a recording of the launch on YouTube.
Science

Why GPS Fails In Cities. And What Researchers Think Could Fix It (sciencedaily.com) 45

ScienceDaily reports: Our everyday GPS struggles in "urban canyons," where skyscrapers bounce satellite signals, confusing even advanced navigation systems. Norwegian University of Science and Technology (NTNU) scientists created SmartNav, combining satellite corrections, wave analysis, and Google's 3D building data for remarkable precision. Their method achieved accuracy within 10 centimeters during testing [90% of the time]. The breakthrough could make reliable urban navigation accessible and affordable worldwide...

"Cities are brutal for satellite navigation," explained Ardeshir Mohamadi. Mohamadi, a doctoral fellow at NTNU, is researching how to make affordable GPS receivers (like those found in smartphones and fitness watches) much more precise without depending on expensive external correction services.

EU

New Large Coral Reef Discovered Off Naples Containing Rare Ancient Corals (independent.co.uk) 13

Off the southwest cost of Italy, a remotely operated submarine made "a significant and rare discovery," reports the Independent — a vast white coral reef that was 80 metres tall (262 feet) and 2 metres wide (6.56 feet) "containing important species and fossil traces." Often dubbed the "rainforests of the sea", coral reefs are of immense scientific interest due to their status as some of the planet's richest marine ecosystems, harbouring millions of species. They play a crucial role in sustaining marine life but are currently under considerable threat...

hese impressive formations are composed of deep-water hard corals, commonly referred to as "white corals" because of their lack of colour, specifically identified as Lophelia pertusa and Madrepora oculata species. The reef also contains black corals, solitary corals, sponges, and other ecologically important species, as well as fossil traces of oysters and ancient corals, the Italian Research Council said. It called them "true geological testimonies of a distant past."

Mission leader Giorgio Castellan said the finding was "exceptional for Italian seas: bioconstructions of this kind, and of such magnitude, had never been observed in the Dohrn Canyon, and are rarely seen elsewhere in our Mediterranean". The discovery will help scientists understand the ecological role of deep coral habitats and their distribution, especially in the context of conservation and restoration efforts, he added.

The undersea research was funded by the EU.

Thanks to davidone (Slashdot reader #12,252) for sharing the article.
Earth

Scientists Seek To Turbocharge a Natural Process That Cools the Earth 97

fjo3 shares a report from the Washington Post: Across vast stretches of farmland in southern Brazil, researchers at a carbon removal company are attempting to accelerate a natural process that normally unfolds over thousands or millions of years. The company, Terradot, is spreading tons of volcanic rock crushed into a fine dust over land where soybeans, sugar cane and other crops are grown. As rain percolates through the soil, chemical reactions pull carbon from the air and convert it into bicarbonate ions that eventually wash into the ocean, where the carbon remains stored. The technique, known as "enhanced rock weathering," is emerging as a promising approach to lock away carbon on a massive scale. Some researchers estimate the method has the potential to sequester billions of tons of carbon, helping slow global climate trends. Other major projects are underway across the globe and have collectively raised over a quarter-billion dollars. [...]

Terradot was founded in 2022 at Stanford, growing out of an independent study between James Kanoff, an undergraduate seeking large-scale carbon removal solutions, and Scott Fendorf, an Earth science professor. Terradot ran a pilot project across 250 hectares in Mexico and began operations in Brazil in late 2023. Since then, the company has spread about 100,000 tons of rock over 4,500 hectares. It has signed contracts to remove about 300,000 tons of carbon dioxide and is backed by a who's who of Silicon Valley. It expects to deliver its first carbon removal credit -- representing one metric ton of verified carbon dioxide removed -- by the end of this year and then scale up from there.
Science

He Was Expected To Get Alzheimer's 25 Years Ago. Why Hasn't He? (nytimes.com) 44

Doug Whitney carries a genetic mutation that guaranteed he would develop Alzheimer's disease in his late forties or early fifties. His mother and nine of her thirteen siblings died from the disease. His oldest brother died at 45. The mutation has decimated his family for generations. Whitney is now 76 and remains cognitively healthy. The New York Times has a fascinating long read on Whitney and things happening around him.

Scientists at Washington University School of Medicine in St. Louis have studied Whitney for 14 years. They extract his cerebrospinal fluid and conduct brain scans during his periodic visits from Washington State. His brain contains heavy amyloid deposits but almost no tau tangles in regions associated with dementia. Tau accumulation correlates directly with cognitive decline. Whitney accumulated tau only in his left occipital lobe, an area that does not play a major role in Alzheimer's.

Researchers identified several possibly protective factors in Whitney's biology. His immune system produces a lower inflammatory response than other mutation carriers. He has unusually high levels of heat shock proteins, which prevent proteins from misfolding. Scientists believe his decade working in Navy engine rooms at temperatures reaching 110 degrees may have driven this accumulation. He also carries three gene variants his afflicted relatives lack. His son Brian inherited the mutation and remains asymptomatic at 43. Brian received anti-amyloid drugs in clinical trials. Researchers published their findings on Whitney in Nature Medicine. They described the study as a call for other scientists to help solve the case.
Science

The World's Biggest Citizen Science Project (phys.org) 7

eBird, now the world's largest citizen science project with over 2 billion bird observations, is transforming ornithology by turning casual birders (and even TikTok-using kids) into vital contributors to global research and conservation. Slashdot reader alternative_right shares a report from Phys.org: The Cornell Lab of Ornithology has been one of the most influential organizations in the world when it comes to encouraging people to engage in natural history projects. While some form of amateur involvement in science projects has been around since 1900, when the Audubon Society organized the first Christmas Bird Count, it was the Cornell Lab that formalized citizen science as a sound and reliable means of collecting data on birds.

It didn't take much thought to realize that one of the richest sources of information about birds resided in the notebooks virtually every birder has kept, often from childhood. It's a given that birdwatchers list everything. The problem is that zillions of such notebooks sit forgotten in drawers or in dusty boxes in the attic. If only all of that information could be gathered together, organized in sensible ways and then made available to anyone who wanted to use it. What a resource that would be!

After lots of trials and discussion, a small team at the Lab came up with the idea of eBird. It started in a humble way back in 2002, as simply somewhere birders could store their records in a central location. Today, "humble" is no longer an appropriate description. In 2022, its 20th anniversary year, a total of more than 1.3 billion records had been received from more than 820,000 participants. In the month of August this year, reports eBird, 123,000 birders submitted 1.6 million lists of sightings. It has now hit a total of 2 billion bird observations since inception.

EU

EU Lawmakers Push To Ban Plant-Based Food Terms (theguardian.com) 193

An anonymous reader quotes a report from The Guardian: MEPs voted on Wednesday by 355 in favor to 247 against to reserve names such as "steak", "burger" and "sausage" exclusively for products derived from meat, a longstanding demand of farm unions. In order to come into effect, the idea would have to be approved by a majority of the EU's 27 member states, which is far from certain. The vote is a victory for the French centre-right MEP Celine Imart, who drafted the amendment to legislation intended to strengthen the position of farmers in the food supply chain.

Imart, who is also a cereals farmer in north-west France, said: "A steak, an escalope or a sausage are products from our livestock, not laboratory art nor plant products. There is a need for transparency and clarity for the consumer and recognition for the work of our farmers." She argues the proposal is in line with EU rules that already ban the use of terms such as "milk" and "yoghurt" for non-dairy products.

The European parliament rejected a ban on meaty names for plant-based products in 2020, but the 2024 elections shifted the parliament to the right, bringing in more lawmakers who seek close ties with farmers. Opposition was led by Green MEPs, who decried what they saw as a populist move to rename plant-based foods. "Veggie burgers, seitan schnitzel and tofu sausage do not confuse consumers, only rightwing politicians," Thomas Waitz, an Austrian Green MEP, said after the vote. "This tactic is a diversion and a pathetic smokescreen. No farmer will earn more money or secure their future with this ban."

Medicine

Amazon Installing Automated Medication Kiosks At Clinics 15

Amazon Pharmacy will begin offering prescription pickup kiosks at its One Medical clinics starting in Los Angeles this December, allowing patients to collect common medications like antibiotics and inhalers without waiting for delivery. Reuters reports: The kiosks will be the first in-person pick-up service offered by Amazon Pharmacy, which has been providing prescription services primarily by delivery, said Hannah McClellan Richards, a vice president at Amazon Pharmacy. One Medical offers a membership structure that allows patients to access primary and urgent care at a subscription fee of $199 annually. Patients without a membership are still able to book an appointment and would be able to use the kiosk, the company said.

Richards said in an interview that the company plans to expand the kiosk model outside of California in 2026 and is in talks with external health systems to introduce the machines through partnerships. Amazon does not plan to offer medicines that must be refrigerated, such as GLP-1 weight-loss drugs, or more tightly regulated prescriptions like controlled pain medicines through the kiosk. Inventory for each kiosk will be tailored to the provider, and patients would be able to consult a company pharmacist virtually, Amazon said in a press release.
Science

Nobel Prize in Chemistry Awarded To Architects of Metal-Organic Frameworks 16

Susumu Kitagawa, Richard Robson, and Omar M. Yaghi were awarded the Nobel Prize in Chemistry on Wednesday for the development of molecular building blocks with spaces large enough that gases and other chemicals can flow through them. The New York Times: The cavities on the inside are "almost like rooms in a hotel, so that guest molecules can enter and also exit again from the same material," Heiner Linke, chair of the Nobel Committee for Chemistry, said during the announcement of the award. The laureates' discoveries, he added, pave the way for the creation of materials that can separate toxic chemicals from wastewater or harvest water molecules in a desert.

The laureates' work started with experiments by Dr. Robson in the 1980s and gradually developed over a period of about 15 years. "It takes time for science to be recognized, and it takes multiple workers in the field with different approaches," said Dorothy Phillips, president of the American Chemical Society. The three laureates will share a prize of 11 million Swedish kronor, or around $1.17 million.
Medicine

Should the Autism Spectrum Be Split Apart? (hawaiitribune-herald.com) 162

XXongo writes: A New York times article suggests that merging the diagnosis of Asperger's syndrome into the Autism diagnosis in 2013, thus creating the "autism spectrum disorder," was not helpful (paywalled; alternative source). That broadening of the diagnosis, along with the increasing awareness of the disorder, is largely responsible for the steep rise in autism cases that Health Secretary Robert F. Kennedy Jr. has called "an epidemic" and has attributed to theories of causality that mainstream scientists reject, like vaccines and, more recently, Tylenol. But the same diagnosis now applies to both people who are non-verbal, frequently engage in self-destructive behavior such as pounding their heads against the floor, and may require full-time care, but also to people who are merely somewhat socially awkward, possibly engage in repetitive behaviors, and have a narrow range of interests. "Everything changed when we included Asperger's [in the diagnosis of autism]," said Dr. Eric Fombonne, a psychiatrist and researcher at Oregon Health & Science University. He noted that in the earliest studies of autism rates, 75% of people with the diagnosis had intellectual disabilities. Now, only about a third do.
Science

Nobel Prize in Physics Is Awarded for Work in Quantum Mechanics 18

The New York Times: John Clarke, Michel H. Devoret and John M. Martinis were awarded the Nobel Prize in Physics on Tuesday in Sweden for showing that two properties of quantum mechanics, the physical laws that rule the subatomic realm, could be observed on a system large enough to see with the naked eye. They will share a prize of 11 million Swedish kroner, or around $1.17 million.

"There is no advanced technology today that does not rely on quantum mechanics," Olle Eriksson, chairman of the Nobel Committee for Physics, said during the announcement of the award. The laureates' discoveries, he added, paved the way for technologies like the cellphone, cameras and fiber optic cables.

It also helped lay the groundwork for current attempts to build a quantum computer, a device that could compute and process information at speeds that would not be possible with classical computer.
Martinis worked at Google from 2014 to 2020 to build a quantum computer and led the quantum supremacy experiment in 2019. Devoret is cited in Google's recent breakthrough where its Willow quantum chip solved a problem in five minutes that the world's most advanced supercomputer could never solve.

The three laureates conducted experiments with electrical circuits that demonstrated quantum mechanical tunneling and quantized energy levels in systems large enough to hold in the hand. Clarke is a professor at the University of California, Berkeley. Devoret joined his research group in the 1980s and is now at Yale University and UC Santa Barbara. Martinis also joined the group in the 1980s and is currently at UC Santa Barbara and co-founded Qolab, a startup developing utility-scale superconducting quantum computers.
Space

Black Holes Might Hold the Key To a 60-Year Cosmic Mystery 20

alternative_right shares a report from ScienceDaily: Scientists may have finally uncovered the mystery behind ultra-high-energy cosmic rays -- the most powerful particles known in the universe. A team from NTNU suggests that colossal winds from supermassive black holes could be accelerating these particles to unimaginable speeds. These winds, moving at half the speed of light, might not only shape entire galaxies but also fling atomic nuclei across the cosmos with incredible energy. [...]

But what on earth does that mean? The Milky Way is the neighborhood in the universe where you and I live. Our Sun and solar system are part of this galaxy, along with at least 100 billion other stars. "There is a black hole called Sagittarius-A* located right in the centre of the Milky Way. This black hole is currently in a quiet phase where it isn't consuming any stars, as there is not enough matter in the vicinity," [said postdoctoral fellow Enrico Peretti from the Universite Paris Cite]. This contrasts with growing, supermassive, active black holes that consume up to several times the mass of our own Sun each year. "A tiny portion of the material can be pushed away by the force of the black hole before it is pulled in. As a result, around half of these supermassive black holes create winds that move through the universe at up to half the speed of light," Peretti said.

We have known about these gigantic winds for approximately ten years. The winds from these black holes can affect galaxies. By blowing away gases, they can prevent new stars from forming, for example. This is dramatic enough in itself, but Oikonomou and her colleagues looked at something else, much smaller, that these winds could be the cause of." It is possible that these powerful winds accelerate the particles that create the ultra-high-energy radiation," said [lead author Domenik Ehlert].
The findings have been published in the journal Monthly Notices of the Royal Astronomical Society.
Education

Quarter of UK University Physics Departments At Risk of Closing, Survey Finds (theguardian.com) 86

An anonymous reader quotes a report from The Guardian: The heads of UK physics departments say their subject is facing a national crisis as one in four warns that their university departments are in danger of closing because of funding pressures. In an anonymous survey of department heads by the Institute of Physics (IoP), 26% said they faced potential closure of their department within the next two years, while 60% said they expected courses to be reduced. Four out of five departments said they were making staff cuts, and many were considering mergers or consolidation in what senior physicists described as a severe threat to the UK's future success. [...]

To avoid "irreversible damage", the IoP is asking for immediate government action including funding to support existing labs and research facilities, as well as setting up an "early warning system" to monitor departments at risk of closure, and reduce pressures affecting international student recruitment. In the longer term it is calling for radical reforms in higher education funding to allow universities to meet the full costs of teaching nationally important subjects such as physics. Sir Keith Burnett, the IoP's president and a former chair of physics at Oxford University, said: "While we understand the pressures on public finances, it would be negligent not to sound the alarm for a national capability fundamental to our wellbeing, competitiveness and the defense of the realm.

"We are walking towards a cliff edge but there is still time to avert a crisis which would lead not just to lost potential but to many physics departments shutting down altogether. Physics researchers and talented physics students are our future but if action isn't taken now to stabilize, strengthen and sustain one of our greatest national assets, we risk leaving them high and dry." Thomas said the erosion in value of domestic tuition fees and falling numbers of international students were behind the financial pressures, with smaller physics departments the most at risk. "What that means is we will get more and more concentration of where physics is being taught and lose geographical distribution. That goes against aims of widening participation and means some disadvantaged groups will miss out on opportunities to study physics, and it's important that we recognize that," Thomas said.

Businesses

AstraZeneca Signs Up For $555 Million AI Deal With Algen To Develop Therapies

AstraZeneca has licensed Algen Biotechnologies' AI-powered gene-editing platform, AlgenBrain, to develop immune-related therapies in a deal worth up to $555 million. Reuters reports: AstraZeneca will get exclusive rights to develop and sell approved therapies, if any, that target immune system-related disorders in exchange for upfront and milestone payments to Algen. AstraZeneca has been advancing its cell and gene therapy capabilities through acquisitions and partnerships as it works towards its target of $80 billion in sales by 2030. Globally too, drugmakers are increasingly turning to artificial intelligence for drug development.

Monday's deal, however, does not include AstraZeneca buying a stake in the company, Algen CEO and co-founder Chun-Hao Huang told Reuters in an interview. "Together with AstraZeneca's deep expertise in translational science and clinical development, we aim to uncover new biological insights to accelerate the development of novel therapies," Huang said. Algen was spun out from the UC Berkeley lab where biochemist Jennifer Doudna pioneered the CRISPR technology that won her the Nobel Prize. The biotech firm's AI platform, AlgenBrain, can map genes to disease outcomes, helping the companies decide their development focus for targeted therapies.
Biotech

California Biotech Tycoon Found Guilty of Orchestrating Rival's Murder (sfgate.com) 22

California biotech entrepreneur and former magician Serhat Gumrukcu has been found guilty of orchestrating the 2018 murder of his business rival Gregory Davis, who had threatened to expose Gumrukcu's fraudulent dealings. He faces sentencing in November. SFGATE reports: Seven years ago, Turkish national Serhat Gumrukcu, 42, of Los Angeles, was negotiating a multimillion-dollar biotech merger built off his work on a supposed HIV cure. The deal was put in jeopardy by a former business partner named Gregory Davis, 49, who had threatened to bring legal action against Gumrukcu for fraudulent activities relating to a previous failed oil commodities deal, the U.S. Attorney's Office said in a news release last week. Gumrukcu, a magician-turned-scientist who admitted to buying his medical degree from a Russian university, lived in a Hollywood mansion and partied with Oscar winners and movie producers, according to VTDigger. He stood to make millions from the merger of his biotech company Enochian BioSciences. [...]

In 2017, upon learning that Davis, a father of six from Danville, Vermont, could potentially spoil his fortune-making deal, Gumrukcu set in motion a hit on the former business partner. The murder-for-hire plot involved four men in total, prosecutors said. Gumrukcu had a close friend from Las Vegas, Berk Eratay, approach a third man, Aron Ethridge to find a hit man to kill Davis. The shooter, 37-year-old Montana man Jerry Banks, arrived at Davis' home on Jan. 6, 2018, in a vehicle fitted with flashing red and blue lights and posed as a deputy U.S. marshal. After abducting Davis, Banks shot him dead in the vehicle and left the body partially buried in a snowbank nearby.

Investigators soon narrowed in on Gumrukcu after discovering emails between him and Davis revealing tensions over the failed oil deal. Gumrukcu was interviewed twice by the FBI and made false statements on both occasions, federal prosecutors said. Further inspection of cellphone data, bank information and messages identified the four men involved in the kidnapping and killing of Davis.

Science

Immune System Research Earns Nobel Prize for Brunkow, Ramsdell and Sakaguchi (npr.org) 18

Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi received the Nobel Prize in Physiology or Medicine on Monday for their discoveries about how the immune system regulates itself. The three researchers split 11 million Swedish kroner ($1.17 million). Their work identified regulatory T cells and the FOXP3 gene that controls them. Dr. Sakaguchi spent more than a decade solving a puzzle about the thymus. He discovered that the immune system has a backup mechanism to stop harmful cells from attacking the body's own tissues. Dr. Brunkow and Dr. Ramsdell found the specific gene responsible for this process while studying mice that developed severe autoimmune disease.

More than 200 clinical trials are now underway based on their research. Cancers attract regulatory T cells to block immune attacks. Researchers are developing drugs to turn the immune system against these cancer cells. In autoimmune diseases, regulatory T cells are missing or defective. The FOXP3 gene provides a starting point for drugs that teach the immune system to stop attacking itself.

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