The Washington Post reports that America's largest pharmacy chains have "handed over Americans' prescription records to police and government investigators without a warrant, a congressional investigation found, raising concerns about threats to medical privacy." Though some of the chains require their lawyers to review law enforcement requests, three of the largest — CVS Health, Kroger and Rite Aid, with a combined 60,000 locations nationwide — said they allow pharmacy staff members to hand over customers' medical records in the store... Pharmacies' records hold some of the most intimate details of their customers' personal lives, including years-old medical conditions and the prescriptions they take for mental health and birth control. Because the chains often share records across all locations, a pharmacy in one state can access a person's medical history from states with more-restrictive laws. Carly Zubrzycki, an associate professor at the University of Connecticut law school, wrote last year that this could link a person's out-of-state medical care via a "digital trail" back to their home state...

In briefings, officials with eight American pharmacy giants — Walgreens Boots Alliance, CVS, Walmart, Rite Aid, Kroger, Cigna, Optum Rx and Amazon Pharmacy — told congressional investigators that they required only a subpoena, not a warrant, to share the records.

A subpoena can be issued by a government agency and, unlike a court order or warrant, does not require a judge's approval. To obtain a warrant, law enforcement must convince a judge that the information is vital to investigate a crime. Officials with CVS, Kroger and Rite Aid said they instruct their pharmacy staff members to process law enforcement requests on the spot, saying the staff members face "extreme pressure to immediately respond," the lawmakers' letter said. The eight pharmacy giants told congressional investigators that they collectively received tens of thousands of legal demands every year, and that most were in connection with civil lawsuits. It's unclear how many were related to law enforcement demands, or how many requests were fulfilled.

Only one of the companies, Amazon, said it notified customers when law enforcement demanded its pharmacy records unless there was a legal prohibition, such as a "gag order," preventing it from doing so, the lawmakers said...

Most investigative requests come with a directive requiring the company to keep them confidential, a CVS spokeswoman said; for those that don't, the company considers "on a case-by-case basis whether it's appropriate to notify the individual."
The article points out that Americans "can request the companies tell them if they've ever disclosed their data...but very few people do.

"CVS, which has more than 40,000 pharmacists and 10,000 stores in the United States, said it received a 'single-digit number' of such consumer requests last year, the letter states."

An anonymous reader shared this report from CNN: Scientists have long viewed Saturn's moon Enceladus, which harbors an ocean beneath its thick, icy shell, as one of the best places to search for life beyond Earth. Now, a new analysis of data collected by NASA's Cassini mission, which orbited Saturn and its moons between 2004 and 2017, has uncovered intriguing evidence that further supports the idea of Enceladus as a habitable ocean world.

Enceladus initially captured the attention of scientists in 2005 because plumes of ice grains and water vapor were observed rising through cracks in the moon's ice shell and releasing into space. The spacecraft flew through the plumes and "sampled" them, with data suggesting the presence of organic compounds within the plumes, some of which are key for life. The latest data analysis of Cassini's flybys of Enceladus revealed the detection of a molecule called hydrogen cyanide that's toxic to humans but crucial to processes driving the origin of life. What's more, the team also found evidence to support that Enceladus' ocean has organic compounds that provide a source of chemical energy that could potentially be used as powerful fuel for any form of life...

The combination of these elements together suggested a process called methanogenesis, or the metabolic creation of methane, may be at play on Enceladus. Scientists suspect methanogenesis may have also played out on early Earth, contributing to the origin of life. But the new research indicates more varied and powerful chemical energy sources are occurring within Enceladus' ocean... Now, the study authors want to investigate how diluted the organic compounds are within the subsurface ocean because the dilution of these compounds could determine whether Enceladus could support life. In the future, astronomers hope to send a dedicated mission to investigate Enceladus, which could provide a definitive answer as to whether life exists in the ocean world.
"Our work provides further evidence that Enceladus is host to some of the most important molecules for both creating the building blocks of life and for sustaining that life through metabolic reactions," accoding to one of the study's lead authors.

"Not only does Enceladus seem to meet the basic requirements for habitability, we now have an idea about how complex biomolecules could form there, and what sort of chemical pathways might be involved."

An anonymous reader shared this report from CNN: The quest for new antibiotics is going back to the Stone Age. The urgency to identify possible candidates has never been greater as the global population faces nearly 5 million deaths every year that are associated with microbial resistance, according to the World Health Organization. A research team led by bioengineering pioneer César de la Fuente is using artificial intelligence-based computational methods to mine genetic information from extinct human relatives such as Neanderthals and long-gone ice age creatures such as the woolly mammoth and giant sloth. The scientists say some of these small protein, or peptide, molecules they have identified have bacteria-fighting powers that may inspire new drugs to fight infections in humans. The innovative work also opens up a completely new way to think about drug discovery.

"It has enabled us to uncover new sequences, new types of molecules that we have not previously found in living organisms, expanding the way we think about molecular diversity," said de la Fuente, Presidential Assistant Professor at the University of Pennsylvania, where he heads the machine biology group. "Bacteria from today have never faced those molecules so they may give us a better opportunity at targeting the pathogens that are problematic today...." The idea to look at extinct molecules came up during a lab brainstorm when the blockbuster movie "Jurassic Park" was mentioned. "The notion (in the film) was to bring back entire organisms, and obviously, they had a lot of issues," De la Fuente said. His team started thinking about a more feasible idea: "Why not bring back molecules from the past?" Advances in the recovery of ancient DNA from fossils mean that detailed libraries of genetic information about extinct human relatives and long-lost animals are now publicly available...

In research expected to publish next year, de la Fuente and his colleagues have developed a new deep-learning model to explore what he describes as the "extinctome" — the protein sequences of 208 extinct organisms for which detailed genetic information is available. The team found more than 11,000 previously unknown potential antimicrobial peptides unique to extinct organisms and synthesized promising candidates... He said that the peptides they discovered displayed "excellent anti-infective activity" in mice.

"Molecular de-extinction offers a unique opportunity to combat antibiotic resistance by resurrecting and tapping into the power of molecules from the past," he said.

In 2020 a NASA spacecraft visited the asteroid Bennu. In October it returned to earth with a sample. Monday scientists got their first data about it at a meeting of the American Geophysical Union — which is a truly big deal.

"Before Earth had biology, it had chemistry," writes the Washington Post. "How the one followed from the other — how a bunch of boring molecules transformed themselves into this special thing we call life — is arguably the greatest unknown in science." The mission's top scientist, Dante Lauretta... showed slides with a long list of intriguing molecules, including carbon-based organics, in the grains and pebbles retrieved from Bennu. They will shine light on the molecular building blocks of the solar system and "maybe — still early phase — maybe insights into the origin of life." This analysis has only just started. The team has not yet released a formal scientific paper. In his lecture, Lauretta cited one interesting triangular, light-colored stone, which he said contained something he'd never seen before in a meteorite. "It's a head-scratcher right now. What is this material?" he said.

In an interview after the lecture, Lauretta said almost 5 percent of the sample is carbon. "That is a very carbon-rich sample — the richest we have in all our extraterrestrial material. ... We're still unraveling the complex organic chemistry, but it looks promising to really understand: Did these carbon-rich asteroids deliver fundamental molecules that may have gone on to contribute to the origin of life...?"

This space dirt has astrobiological import, though. By looking at prebiotic chemistry on Bennu, scientists will have a better idea what they are looking at if and when they find suspicious molecules elsewhere in the solar system, such as on Mars, Jupiter's moon Europa or Saturn's moon Enceladus. "This is almost the perfect laboratory control from non-biological chemistry," Glavin said. "This better prepares us for our search for life on Mars, or Europa or Enceladus — places that might have had life at one point."
Space.com quotes Lauretta as saying "We definitely have hydrated, organic-rich remnants from the early solar system, which is exactly what we were hoping when we first conceived this mission almost 20 years ago."