Satellite navigation systems for lunar settlements will require local atomic clocks. Scientists are working out what time they will keep. From a report: It's not obvious what form a universal lunar time would take. Clocks on Earth and the Moon naturally tick at different speeds, because of the differing gravitational fields of the two bodies. Official lunar time could be based on a clock system designed to synchronize with UTC, or it could be independent of Earth time. Representatives of space agencies and academic organizations worldwide met in November 2022 to start drafting recommendations on how to define lunar time at the European Space Research and Technology Centre of the European Space Agency (ESA) in Noordwijk, the Netherlands.

Decisions must be made soon, says Patrizia Tavella, who leads the time department at the International Bureau of Weights and Measures in Sevres, France. If an official lunar time is not established, space agencies and private companies will come up with their own solutions, she says. "This is why we want to raise an alert now, saying let's work together to take a common decision." The most pressing need for lunar time comes from plans to create a dedicated global satellite navigation system (GNSS) for the Moon, similar to how GPS and other satellite navigation networks enable precise location tracking on Earth.

Space agencies plan to install this lunar GNSS from around 2030. ESA approved a lunar satellite navigation project called Moonlight at its ministerial council meeting on 22 and 23 November 2022 in Paris, and NASA established a similar project, called Lunar Communications Relay and Navigation Systems, last January. Until now, Moon missions have pinpointed their locations using radio signals sent to large antennas on Earth at scheduled times. But with dozens of missions planned, "there's just not enough resources to cover everybody," says Joel Parker, an engineer who works on lunar navigation at the Goddard Center.

The New York Times looks at the AbbVie's anti-inflammatory drug Humira and their "savvy but legal exploitation of the U.S. patent system." Though AbbVie's patent was supposed to expire in 2016, since then it's maintained a monopoly that generated $114 billion in revenue by using "a formidable wall of intellectual property protection and suing would-be competitors before settling with them to delay their product launches until this year." AbbVie did not invent these patent-prolonging strategies; companies like Bristol Myers Squibb and AstraZeneca have deployed similar tactics to maximize profits on drugs for the treatment of cancer, anxiety and heartburn. But AbbVie's success with Humira stands out even in an industry adept at manipulating the U.S. intellectual-property regime.... AbbVie and its affiliates have applied for 311 patents, of which 165 have been granted, related to Humira, according to the Initiative for Medicines, Access and Knowledge, which tracks drug patents. A vast majority were filed after Humira was on the market.

Some of Humira's patents covered innovations that benefited patients, like a formulation of the drug that reduced the pain from injections. But many of them simply elaborated on previous patents. For example, an early Humira patent, which expired in 2016, claimed that the drug could treat a condition known as ankylosing spondylitis, a type of arthritis that causes inflammation in the joints, among other diseases. In 2014, AbbVie applied for another patent for a method of treating ankylosing spondylitis with a specific dosing of 40 milligrams of Humira. The application was approved, adding 11 years of patent protection beyond 2016.

AbbVie has been aggressive about suing rivals that have tried to introduce biosimilar versions of Humira. In 2016, with Amgen's copycat product on the verge of winning regulatory approval, AbbVie sued Amgen, alleging that it was violating 10 of its patents. Amgen argued that most of AbbVie's patents were invalid, but the two sides reached a settlement in which Amgen agreed not to begin selling its drug until 2023.

Over the next five years, AbbVie reached similar settlements with nine other manufacturers seeking to launch their own versions of Humira. All of them agreed to delay their market entry until 2023.
A drug pricing expert at Washington University in St. Louis tells the New York Times that AbbVie and its strategy with Humira "showed other companies what it was possible to do."

But the article concludes that last year such tactics "became a rallying cry" for U.S. lawmakers "as they successfully pushed for Medicare to have greater control over the price of widely used drugs that, like Humira, have been on the market for many years but still lack competition."

segaboy81 shares a report from Neowin: What do you get when the world's largest CRM breaks into the research industry and leverages AI to build their products? You get ProGen, a new AI system that can make artificial enzymes from scratch that can work just as well as real ones found in nature. ProGen was made by Salesforce Research (yes, that Salesforce) and uses language processing to learn about biology. In short, ProGen takes amino acid sequences and turns them into proteins....

"The artificial designs are better than ones made by the normal process," said James Fraser, a scientist involved in the project. "We can now make specific types of enzymes, like ones that work well in hot temperatures or acid."

To make ProGen, the scientists at Salesforce fed the system amino acid sequences from 280 million different proteins. The AI system quickly made a staggering one million protein sequences, of which 100 were picked to test. Out of these, five were made into actual proteins and tested in cells. That's just 0.0005% of the generated results....

The code for ProGen is available on Github for anyone who wants to try it (or add to it)
The project shows "how generative AI can lead to potential solutions for addressing challenges in human disease and the environment," argues a statement form Salesforce.

More details from New Scientist: The AI, called ProGen, works in a similar way to AIs that can generate text. ProGen learned how to generate new proteins by learning the grammar of how amino acids combine to form 280 million existing proteins. Instead of the researchers choosing a topic for the AI to write about, they could specify a group of similar proteins for it to focus on. In this case, they chose a group of proteins with antimicrobial activity.

The researchers programmed checks into the AI's process so it wouldn't produce amino acid "gibberish", but they also tested a sample of the AI-proposed molecules in real cells. Of the 100 molecules they physically created, 66 participated in chemical reactions similar to those of natural proteins that destroy bacteria in egg whites and saliva. This suggested that these new proteins could also kill bacteria. The researchers selected the five proteins with the most intense reactions and added them to a sample of Escherichia coli bacteria. Two of the proteins destroyed the bacteria.

The researchers then imaged them with X-rays. Even though their amino acid sequences were up to 30% different from any existing proteins, their shapes almost matched naturally occurring proteins. James Fraser at the University of California, San Francisco, who was part of the team, says it was not clear from the outset that the AI could work out how to change the amino acid sequence so much and still produce the correct shape.... He was surprised to have found a well-functioning protein in the first relatively small fraction of all the ProGen-generated proteins that they tested.

Researchers from the University of Birmingham have developed an innovative method for existing furnaces that could reduce steelmaking's CO2 emission by nearly 90%. The Next Web reports: The iron and steel industry is a major cause of greenhouse gasses, accounting for 9% of global emissions. That's because of the inherent carbon-intensive nature of steel production in blast furnaces, which currently represent the most-widely used practice. In blast furnace steel manufacturing, coke (a type of coal) is used to produce metallic iron from ore obtained from mining -- which releases large quantities of carbon dioxide in the process. According to Dr Harriet Kildahl, who co-devised the method with Professor Yulong Ding, their technology aims to convert this carbon dioxide into carbon monoxide that can be reused in the iron ore reaction.

This is realized using a thermochemical cycle which performs chemical reactions through changes in temperature. That way, the typically damaging CO2 is turned into a useful part of the reaction, forming "an almost perfect closed carbon loop." This drastically reduces emission by the amount of coke needed and, subsequently, lowers steelmaking's emissions by up to 88%. As per the researchers, if this method was implemented in the remaining two blast furnaces in the UK, it could save 1.28 billion pounds in 5 years, all while reducing the country's overall emissions by 2.9%.

"Current proposals for decarbonizing the steel sector rely on phasing out existing plants and introducing electric arc furnaces powered by renewable electricity. However, an electric arc furnace plant can cost over 1 billion pounds to build, which makes this switch economically unfeasible in the time remaining to meet the Paris Climate Agreement," Professor Ding said. "The system we are proposing can be retrofitted to existing plants, which reduces the risk of stranded assets, and both the reduction in CO2, and the cost savings, are seen immediately." The study has been published in the Journal of Cleaner Production.

An anonymous reader quotes a report from MIT Technology Review: Eight years ago, a patient lost her power of speech because of ALS, or Lou Gehrig's disease, which causes progressive paralysis. She can still make sounds, but her words have become unintelligible, leaving her reliant on a writing board or iPad to communicate. Now, after volunteering to receive a brain implant, the woman has been able to rapidly communicate phrases like "I don't own my home" and "It's just tough" at a rate approaching normal speech. That is the claim in a paper published over the weekend on the website bioRxiv by a team at Stanford University. The study has not been formally reviewed by other researchers. The scientists say their volunteer, identified only as "subject T12," smashed previous records by using the brain-reading implant to communicate at a rate of 62 words a minute, three times the previous best. [...] People without speech deficits typically talk at a rate of about 160 words a minute. Even in an era of keyboards, thumb-typing, emojis, and internet abbreviations, speech remains the fastest form of human-to-human communication.

The brain-computer interfaces that [co-lead author Krishna Sehnoy's] team works with involve a small pad of sharp electrodes embedded in a person's motor cortex, the brain region most involved in movement. This allows researchers to record activity from a few dozen neurons at once and find patterns that reflect what motions someone is thinking of, even if the person is paralyzed. In previous work, paralyzed volunteers have been asked to imagine making hand movements. By "decoding" their neural signals in real time, implants have let them steer a cursor around a screen, pick out letters on a virtual keyboard, play video games, or even control a robotic arm. In the new research, the Stanford team wanted to know if neurons in the motor cortex contained useful information about speech movements, too. That is, could they detect how "subject T12" was trying to move her mouth, tongue, and vocal cords as she attempted to talk?

These are small, subtle movements, and according to Sabes, one big discovery is that just a few neurons contained enough information to let a computer program predict, with good accuracy, what words the patient was trying to say. That information was conveyed by Shenoy's team to a computer screen, where the patient's words appeared as they were spoken by the computer. [...] The current system already uses a couple of types of machine learning programs. To improve its accuracy, the Stanford team employed software that predicts what word typically comes next in a sentence. "I" is more often followed by "am" than "ham," even though these words sound similar and could produce similar patterns in someone's brain. Adding the word prediction system increased how quickly the subject could speak without mistakes.

The publishers of thousands of scientific journals have banned or restricted contributors' use of an advanced AI-driven chatbot amid concerns that it could pepper academic literature with flawed and even fabricated research. From a report: ChatGPT, a fluent but flaky chatbot developed by OpenAI in California, has impressed or distressed more than a million human users by rattling out poems, short stories, essays and even personal advice since its launch in November. But while the chatbot has proved a huge source of fun -- its take on how to free a peanut butter sandwich from a VCR, in the style of the King James Bible, is one notable hit -- the program can also produce fake scientific abstracts that are convincing enough to fool human reviewers. ChatGPT's more legitimate uses in article preparation have already led to it being credited as a co-author on a handful of papers.

The sudden arrival of ChatGPT has prompted a scramble among publishers to respond. On Thursday, Holden Thorp, the editor-in-chief of the leading US journal Science, announced an updated editorial policy, banning the use of text from ChatGPT and clarifying that the program could not be listed as an author. Leading scientific journals require authors to sign a form declaring that they are accountable for their contribution to the work. Since ChatGPT cannot do this, it cannot be an author, Thorp says. But even using ChatGPT in the preparation of a paper is problematic, he believes. ChatGPT makes plenty of errors, which could find their way into the literature, he says, and if scientists come to rely on AI programs to prepare literature reviews or summarise their findings, the proper context of the work and the deep scrutiny that results deserve could be lost. "That is the opposite direction of where we need to go," he said. Other publishers have made similar changes. On Tuesday, Springer-Nature, which publishes nearly 3,000 journals, updated its guidelines to state that ChatGPT cannot be listed as an author. But the publisher has not banned ChatGPT outright. The tool, and others like it, can still be used in the preparation of papers, provided full details are disclosed in the manuscript.

A wearable ultrasound imager for the heart that is roughly the size of a postage stamp, can be worn for up to 24 hours, and works even during exercise may one day help doctors spot cardiac problems that current medical technology might miss, a new study finds. IEEE Spectrum reports: Now scientists have developed a wearable ultrasound device that can enable safe, continuous, real-time, long-term, and highly detailed imaging of the heart. They detailed their findings online on January 25 in the journal Nature. "Potential applications include continuously monitoring the heart in daily life, during exercise, during surgery, and much more," says study coauthor Ray Wu, a nanoengineer at UC San Diego. "This will open up the possibility to detect previously undetectable symptoms of disease, identify symptoms in their very early stages, and greatly improve patient outcomes."

The new device is a patch 1.9 centimeters long by 2.2 cm wide and only 0.9 millimeters thick. It uses an array of piezoelectric transducers to send and receive ultrasound waves in order to generate a constant stream of images of the structure and function of the heart. The researchers were able to get such images even during exercise on a stationary bike. No skin irritation or allergy was seen after 24 hours of continuous wear. "The most exciting result is that our patch performs well when an individual is moving," Hu says. "Our patch allows us to evaluate heart performance throughout exercise, providing valuable information about the heart when it is under high stress." The new patch is about as flexible as human skin. It can also stretch up to 110 percent of its size, which means it can survive far more strain than typically experienced on human skin. These features help it stick onto the body, something not possible with the rigid equipment often used for cardiac imaging.

In the new study, the researchers focused on imaging the left ventricle, the largest of the heart's four chambers "and strongly considered to be the most important in terms of cardiovascular health, as it is responsible for pumping oxygenated blood to the entire body," Wu says. Cardiac imaging generally focuses on the left ventricle, but the new device can image all of the heart's four chambers simultaneously, "so it may be possible for future research to focus on other or multiple chambers," he adds. In addition, "the imager can be applied to image various other organs, such as the stomach, kidney, or liver." Traditional cardiac ultrasound imaging constantly rotates an ultrasound probe to analyze the heart in multiple dimensions. To eliminate the need for this rotation, the array of ultrasound sensors and emitters in the new device is shaped like a cross so that ultrasonic waves can travel at right angles to each other. The scientists developed a custom deep-learning AI model that can analyze the data from the patch and automatically and continuously estimate vital details, such as the percentage of blood pumped out of the left ventricle with each beat, and the volume of blood the heart pumps out with each beat and every minute. The root of most heart problems is the heart not pumping enough blood, issues that often manifest only when the body is moving, the researchers note.

A small asteroid is flying very close to Earth on Thursday night, less than a week after astronomers discovered the object. The New York Times reports: The asteroid, named 2023 BU, was scheduled to pass over the southern tip of South America at 7:27 p.m. Eastern time. The asteroid is fairly small -- less than 30 feet across, about the size of a truck -- and will be best visible in the skies to the west of southern Chile. For space watchers unable to view 2023 BU firsthand, the Virtual Telescope Project will be broadcasting the event on its website and YouTube channel. The asteroid will not hit Earth but will make one of the closest approaches ever by such an object, hurtling past Earth at just 2,200 miles above its surface, according to a news release from the NASA Jet Propulsion Laboratory. This encounter puts the asteroid "well within the orbit of geosynchronous satellites," the statement noted, but the asteroid is not on track to hit any.

2023 BU was unknown to NASA, or anyone, until last Saturday. Gennadiy Borisov, an amateur astronomer in Crimea, noticed the asteroid from the MARGO Observatory, a setup of telescopes that he has used to discover other interstellar objects. Astronomers then determined 2023 BU's orbit around the sun and impending trip past Earth using data from the Minor Planet Center, a project sanctioned by the International Astronomical Union. It publishes positions of newly found space objects, including comets and satellites, from information of several observatories worldwide.

Scientists from the U.S. National Institutes of Health found a link between dozens of different viral exposures and a later increased risk of Alzheimer's disease and other brain disorders. Gizmodo reports: They analyzed data from two existing and nationally representative biobank projects tracking the long-term health of residents in Finland and the UK, respectively, collectively involving around 450,000 people. They looked for links between viral infections that led to hospitalization and six neurodegenerative diseases: Alzheimer's disease (the most common form of dementia), ALS, multiple sclerosis, Parkinson's disease, vascular dementia, and generalized dementia. In the Finland data, they initially identified 45 types of viral exposure potentially linked to a greater risk of neurodegenerative illness. To double-check these results, they then ran the same sort of analysis on the UK data and found a similar relationship for 22 types of viral exposure across both datasets.

Some of these exposures involved specific viral infections, such as influenza, varicella zoster virus (the cause of chickenpox and shingles), and herpes simplex viruses. Others concerned where an infection or its harmful effects took place, such as viral encephalitis or meningitis, types of brain inflammation that can be caused by many different viruses. For some exposures, the risk of subsequent brain illness extended up to 15 years later, while the strongest link was seen between viral encephalitis and Alzheimer's. The team's findings were published earlier this month in Neuron. "As vaccines are currently available for some of the associated viruses, vaccination may be a way to reduce some risk of neurodegenerative disease," the authors note.

On Monday, SpaceX fueled a fully stacked Starship for the first time. Engadget reports: The "wet dress rehearsal" saw the company load the vehicle's Super Heavy and Starship stages with more than 10 million pounds of liquid oxygen and methane fuel. Additionally, SpaceX ran through some of the countdown procedures it will need to complete on launch day. "Today's test will help verify a full launch countdown sequence, as well as the performance of Starship and the orbital pad for flight-light operations," SpaceX posted on Twitter. As Space.com notes, Monday's test means SpaceX is on track to complete an orbital flight of Starship sometime in the coming months.

The hands of the Doomsday Clock are closer to midnight than ever before, with humanity facing a time of "unprecedented danger" that has increased the likelihood of a human-caused apocalypse, a group of scientists announced Tuesday. From a report: The Bulletin of Atomic Scientists -- a nonprofit organization made up of scientists, former political leaders and security and technology experts -- moved the hands of the symbolic clock 10 seconds forward, to 90 seconds to midnight. The adjustment, made in response to threats from nuclear weapons, climate change and infectious diseases such as Covid-19, is the closest the clock has been to symbolic doom since it was created more than 75 years ago.

"We are living in a time of unprecedented danger, and the Doomsday Clock time reflects that reality," Rachel Bronson, president and CEO of the Bulletin of the Atomic Scientists, said in a statement, adding that "it's a decision our experts do not take lightly." The Doomsday Clock was created to convey the proximity of catastrophic threats to humanity, serving as a metaphor for public and world leaders, rather than a predictive tool. When it was unveiled in 1947, the clock was set at 7 minutes to midnight, with "midnight" signifying human-caused apocalypse. At the height of the Cold War, it was set at 2 minutes to midnight. In 2020, the Bulletin set the Doomsday Clock at 100 seconds to midnight, the first time it had moved within the two-minute mark. For the next two years, the hands were left unchanged.

Amazon said on Tuesday it is offering a $5 monthly subscription plan for U.S. Prime members that will cover a range of generic drugs and their doorstep delivery, furthering the ecommerce giant's push into healthcare. From a report: The program, named RxPass, includes more than 50 medications addressing over 80 chronic conditions such as high blood pressure, anxiety, diabetes and male pattern baldness, Vin Gupta, Amazon Pharmacy's chief medical officer, told Reuters. However, customers enrolled in Medicare, Medicaid or any other government healthcare program will not be able to enroll in Amazon Pharmacy's RxPass service.

The average Prime member would save about $100 per year with RxPass, John Love, vice president of Amazon Pharmacy, said in an interview. Amazon Prime members in most U.S. states can sign up for the program from Tuesday. The flat $5 charge would be without insurance and on top of the Prime membership fee, which costs $139 per year in the United States.

An exotic green comet that has not passed Earth since the time of the Neanderthals has reappeared in the sky ready for its closest approach to the planet next week. The Guardian reports: Discovered last March by astronomers at the Zwicky Transient Facility at the Palomar Observatory in California, comet C/2022 E3 (ZTF) was calculated to orbit the sun every 50,000 years, meaning it last tore past our home planet in the stone age. The comet, which comes from the Oort cloud at the edge of the solar system, will come closest to Earth on Wednesday and Thursday next week when it shoots past the planet at a distance of 2.5 light minutes -- a mere 27m miles.

Comets are balls of primordial dust and ice that swing around the sun in giant elliptical orbits. As they approach the sun, the bodies warm up, turning surface ice into gas and dislodging dust. Together, this creates the cloud or coma which surrounds the comet's hard nucleus and the dusty tail that stretches out behind. Images already taken of comet C/2022 E3 reveal a subtle green glow that is thought to arise from the presence of diatomic carbon -- pairs of carbon atoms that are bound together -- in the head of the comet. The molecule emits green light when excited by the ultraviolet rays in solar radiation.

Since mid-January, the comet has been easier to spot with a telescope or binoculars. It is visible in the northern hemisphere, clouds permitting, as the sky darkens in the evening, below and to the left of the handle of the Plough constellation. It is heading for a fly-by of the pole star, the brightest star in Ursa Minor, next week. The window for spotting the comet does not stay open long. While the best views may be had about February 1 and 2, by the middle of the month the comet will have dimmed again and slipped from view as it hurtles back out into the solar system on its return trip to the Oort cloud.

Far below our feet, a giant may have started moving against us. From a report: Earth's inner core, a hot iron ball the size of Pluto, has stopped spinning in the same direction as the rest of the planet and might even be rotating the other way, research suggested on Monday. Roughly 5,000 kilometres (3,100 miles) below the surface we live on, this "planet within the planet" can spin independently because it floats in the liquid metal outer core. Exactly how the inner core rotates has been a matter of debate between scientists -- and the latest research is expected to prove controversial. What little is known about the inner core comes from measuring the tiny differences in seismic waves -- created by earthquakes or sometimes nuclear explosions -- as they pass through the middle of the Earth.

Seeking to track the inner core's movements, new research published in the journal Nature Geoscience analysed seismic waves from repeating earthquakes over the last six decades. The study's authors, Xiaodong Song and Yi Yang of China's Peking University, said they found that the inner core's rotation "came to near halt around 2009 and then turned in an opposite direction." "We believe the inner core rotates, relative to the Earth's surface, back and forth, like a swing," they told AFP. "One cycle of the swing is about seven decades", meaning it changes direction roughly every 35 years, they added. They said it previously changed direction in the early 1970s, and predicted the next about-face would be in the mid-2040s. The researchers said this rotation roughly lines up with changes in what is called the "length of day" -- small variations in the exact time it takes Earth to rotate on its axis.

"NASA's tiny Ingenuity helicopter now has 40 off-Earth flights under its belt," reports Space.com: The 4-pound (1.8 kilograms) Ingenuity lifted off yet again on Thursday (Jan. 19), staying aloft for nearly 92 seconds on a sortie that covered about 584 feet (178 meters) of horizontal distance. The flight repositioned Ingenuity, moving it from "Airfield Z" on the floor of Mars' Jezero Crater to "Airfield Beta," according to the mission's flight log. That journey took the little chopper over some sand dunes, as imagery captured during the hop shows....

Ingenuity is a technology demonstrator designed to show that aerial exploration is possible on Mars despite the planet's thin atmosphere. The helicopter's prime mission covered just five flights, which Ingenuity knocked out shortly after touching down inside Jezero. The chopper then shifted into an extended mission, during which it has been pushing its flight capabilities and serving as a scout for Perseverance. The helicopter's aerial observations help the rover team identify potentially interesting scientific targets and pick the best routes through the rugged landscapes on Jezero's floor.