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AI

The First Fully AI-Generated Drug Enters Clinical Trials in Human Patients (cnbc.com) 38

"The first drug fully generated by artificial intelligence entered clinical trials with human patients this week," reports CNBC: Insilico Medicine, a Hong Kong-based biotech startup with more than $400 million in funding, created the drug, INS018_055, as a treatment for idiopathic pulmonary fibrosis, a chronic disease that causes scarring in the lungs. The condition, which has increased in prevalence in recent decades, currently affects about 100,000 people in the U.S. and can lead to death within two to five years if untreated, according to the National Institutes of Health.

"It is the first fully generative AI drug to reach human clinical trials, and specifically Phase II trials with patients," Alex Zhavoronkov, founder and CEO of Insilico Medicine, told CNBC. "While there are other AI-designed drugs in trials, ours is the first drug with both a novel AI-discovered target and a novel AI-generated design...."

"When this company was launched, we were focused on algorithms — developing the technology that could discover and design new molecules," Zhavoronkov said. "I never imagined in those early days that I would be taking my own AI drugs into clinical trials with patients. But we realized that in order to validate our AI platform, we needed to not only design a new drug for a new target, but bring it into clinical trials to prove that our technology worked."

"The company has two other drugs partially generated by AI in the clinical stage..."
The Internet

Could a Solar Superstorm Someday Trigger an 'Internet Apocalypse'? (msn.com) 107

"Black Swan events are hard-to-predict rare events that can significantly alter the course of our lives," begins a 2021 paper by a computer science professor at the University of California.

Now the Washington Post revisits that exploration of the possibility that "magnetic fields unleashed by a solar superstorm rip through Earth's magnetosphere, sending currents surging through human infrastructure." A widespread internet outage could, indeed, be brought on by a strong solar storm hitting Earth — a rare but very real event that has not yet happened in the digital age, experts say. When a solar storm known as the Carrington Event struck in 1859, telegraph lines sparked, operators were electrocuted and the northern lights descended to latitudes as low as Jamaica. A 1989 solar storm took out the Quebec power grid for hours. And in 2012, a storm just missed Earth.

As the sun, which has roughly 11-year cycles, enters a particularly active period known as the "solar maximum" in 2025, some are worried our interconnected world is not prepared.

Sangeetha Abdu Jyothi, a computer science professor at University of California at Irvine whose paper "Solar Superstorms: Planning for an Internet Apocalypse" has played a role in popularizing the term, started thinking about internet resilience when the coronavirus began to spread, and she realized how unprepared we were for a pandemic. Research on widespread internet failure was scant. "We've never experienced one of the extreme case events, and we don't know how our infrastructure would respond to it," Jyothi said. "Our failure testing doesn't even include such scenarios."

She notes that a severe solar storm is likely to affect large-scale infrastructure such as submarine communication cables, which could interrupt long-distance connectivity. If you have not lost power, you might have access to, say, a government website hosted locally, but reaching bigger websites, which could have data stored all over the place, might not be possible. The northern latitudes are also especially vulnerable to solar storms, and that's where a lot of internet infrastructure is concentrated. "This is not taken into account in our infrastructure deployment today at all," she said. Such outages could last for months, depending on the scale and how long it takes to repair the damage. The economic impact of just one day of lost connectivity in the United States alone is estimated to be more than $11 billion, according to the internet watcher NetBlocks.

Still, Jyothi says she has felt bad for using the term "internet apocalypse" in her paper. There's not much ordinary people can do to prepare for such a phenomenon; it falls on governments and companies. And the paper "just got too much attention," she said.

"Astrophysicists estimate the likelihood of a solar storm of sufficient strength to cause catastrophic disruption occurring within the next decade to be 1.6 to 12%," the paper concludes. (It also notes that the U.S. has a higher risk for a disconnection than Asia.)

"Paying attention to this threat and planning defenses against it, like our preliminary effort in this paper, is critical for the long-term resilience of the Internet."
Space

SpaceX Launches ESA's 'Euclid' Space Telescope to Study Dark Energy's Effect on the Universe (cnn.com) 19

"The European Space Agency's Euclid space telescope launched at 11:12 a.m. ET Saturday," reports CNN, "aboard a SpaceX Falcon 9 rocket from Florida's Cape Canaveral Space Force Station.

CNN is calling it "a mission designed to unravel some of the greatest mysteries of the universe." The 1.2-meter-diameter (4-foot-diameter) telescope has set off on a monthlong journey to its orbital destination of the sun-Earth Lagrange point L2, which is nearly 1 million miles (1.6 million kilometers) away from Earth and also home to NASA's James Webb Space Telescope... After arriving at orbit, Euclid will spend two months testing and calibrating its instruments — a visible light camera and a near-infrared camera/spectrometer — before surveying one-third of the sky for the next six years. Euclid's primary goal is to observe the "dark side" of the universe, including dark matter and dark energy. While dark matter has never actually been detected, it is believed to make up 85% of the total matter in the universe. Meanwhile, dark energy is a mysterious force thought to play a role in the accelerating expansion of the universe.

In the 1920s, astronomers Georges Lemaître and Edwin Hubble discovered that the universe has been expanding since its birth 13.8 billion years ago. But research that began in the 1990s has shown that something sparked an acceleration of the universe's expansion about 6 billion years ago, and the cause remains a mystery. Unlocking the true nature of dark energy and dark matter could help astronomers understand what the universe is made of, how its expansion has changed over time, and if there is more to understanding gravity than meets the eye... Euclid is designed to create the largest and most accurate three-dimensional map of the universe, observing billions of galaxies that stretch 10 billion light-years away to reveal how matter may have been stretched and pulled apart by dark energy over time. These observations will effectively allow Euclid to see how the universe has evolved over the past 10 billion years...

The telescope's image quality will be four times sharper than those of ground-based sky surveys. Euclid's wide perspective can also record data from a part of the sky 100 times bigger than what Webb's camera can capture. During its observations, the telescope will create a catalog of 1.5 billion galaxies and the stars within them, creating a treasure trove of data for astronomers that includes each galaxy's shape, mass and number of stars created per year. Euclid's ability to see in near-infrared light could also reveal previously unseen objects in our own Milky Way galaxy, such as brown dwarfs and ultra-cool stars.

In May 2027, Euclid will be joined in orbit by the Nancy Grace Roman Telescope. The two missions will overlap in their study of cosmic acceleration as they both create three-dimensional maps of the universe...Roman will study one-twentieth of the sky in infrared light, allowing for much more depth and precision. The Roman telescope will peer back to when the universe was just 2 billion years old, picking out fainter galaxies than Euclid can see.

CNN points out that "While primarily an ESA mission, the telescope includes contributions from NASA and more than 2,000 scientists across 13 European countries, the United States, Canada and Japan."

And they also note this statement from Jason Rhodes, a senior research scientist at NASA's Jet Propulsion Laboratory. "With these upcoming telescopes, we will measure dark energy in different ways and with far more precision than previously achievable, opening up a new era of exploration into this mystery."

From NASA's announcement: Scientists are unsure whether the universe's accelerated expansion is caused by an additional energy component, or whether it signals that our understanding of gravity needs to be changed in some way. Astronomers will use Roman and Euclid to test both theories at the same time, and scientists expect both missions to uncover important information about the underlying workings of the universe...

Less concentrated mass, like clumps of dark matter, can create more subtle effects. By studying these smaller distortions, Roman and Euclid will each create a 3D dark matter map... Tallying up the universe's dark matter across cosmic time will help scientists better understand the push-and-pull feeding into cosmic acceleration.

SpaceX tweeted footage of the telescope's takeoff, and the successful landing of their Falcon 9's first stage on a droneship called A Shortfall of Gravitas.
Science

The Man Who Broke Bowling (gq.com) 60

theodp writes: In The Man Who Broke Bowling, GQ's Eric Wills profiles professional bowler Jason Belmonte, whose two-handed bowling technique made him both an outcast as well as one of bowling's greatest, changing the sport forever. Unlike the rest of us, a 7-year-old Belmonte was unconvinced by the taunts used to prompt kids into switching from bowling two-handed to one-handed ("It was, Come on, you're a big boy now. It's time to bowl properly," Belmonte recalls). As a result, Belmonte was able to develop a 600-rpm throw when most pro bowlers averaged 350-400, imparting a spin that "sends the pins into concussion protocol." Wills writes:

"When he first alighted on the professional bowling scene, Belmonte resembled an alien species: one that bowled with two hands. And not some granny shot, to be clear, but a kickass power move in which he uses two fingers (and no thumb) on his right hand, palms the front of the ball with his left, and then, on his approach, which is marked by a distinctive shuffle step, rocks the ball back before launching it with a liquid, athletic whip, his delivery producing an eye-popping hook, his ball striking the pins like a mini mortar explosion. Not everyone welcomed his arrival. He's been called a cheat, told to go back to his native Australia; a PBA Hall of Famer once called the two-hander a 'cancer to an already diseased sport.'

If you're interested in more on the technical aspects of bowling -- Belmonte's installed a tracking system in his parent's bowling center back in Australia that generates reams of data he can sift through to find areas for improvement -- Wikipedia goes into some of the physics of bowling balls.

Space

Scientists Find 'Ghost Particles' Spewing From Our Milky Way Galaxy (space.com) 16

According to new findings published in the journal Science, astronomers have detected high-energy neutrinos (also known as "ghost particles") coming from within our Milky Way galaxy. Space.com reports: High-energy neutrinos are known to originate from galaxies beyond the Milky Way. But researchers have long suspected that our own galaxy is a source as well. For example, when cosmic rays -- atomic nuclei moving at nearly the speed of light -- strike dust and gas, they generate both gamma rays and high-energy neutrinos. Previous research has detected gamma rays from the Milky Way's plane, so scientists have expected high-energy neutrinos from there as well. There have been hints of such emission, but confirmation has proven elusive to date. The new study took another look, using the IceCube Neutrino Observatory at the Amundsen-Scott South Pole Station. IceCube is embedded within a gigaton (1 billion tons) of ice, making it the first gigaton neutrino detector ever built. IceCube encompasses 0.24 cubic miles (1 cubic kilometer) of Antarctic ice holding more than 5,000 light sensors. These devices watch for the unique flashes of light that result from the rare instances in which neutrinos do smash into atoms.

The research team focused on the plane of the Milky Way, the dense region of the galaxy that lies along the Milky Way's equator. They studied 10 years of IceCube data, analyzing 60,000 neutrinos -- 30 times more than prior neutrino scans of the galactic plane had looked at. [...] This work identified high-energy neutrinos that likely came from the Milky Way's galactic plane. "This observation of high-energy neutrinos opens up an entirely new window to study the properties of our host galaxy," study co-author Mirco Huennefeld, an astroparticle physicist at TU Dortmund University in Germany, told Space.com. "I think it's exciting to see the young field of neutrino astronomy develop with such an increasing pace," Huennefeld added. "It took decades to envision a neutrino telescope such as IceCube, and just in the last few years, we saw an accumulation of exciting observations, including the first evidence of extragalactic sources. Now, with these results, we have achieved a new milestone in neutrino astronomy."

Although the findings suggest that the newfound neutrinos come from our galaxy, IceCube currently is not sensitive enough to pinpoint their sources. They may emerge in a diffuse manner, or a significant number of them might come from specific points in the sky, Huennefeld said. In the coming years, IceCube will get detector upgrades "that will further enhance its sensitivity, allowing us to obtain a clearer picture of the Milky Way in neutrinos in the near future," Huennefeld said. "Answering these questions will have implications on our understanding of cosmic rays and their origin, and also in general on the inferred properties of our host galaxy."

Science

Decades-long Bet on Consciousness Ends (nature.com) 82

Christof Koch wagered David Chalmers 25 years ago that researchers would learn how the brain achieves consciousness by now. But the quest continues. From a report: A 25-year science wager has come to an end. In 1998, neuroscientist Christof Koch bet philosopher David Chalmers that the mechanism by which the brain's neurons produce consciousness would be discovered by 2023. Both scientists agreed publicly on 23 June, at the annual meeting of the Association for the Scientific Study of Consciousness (ASSC) in New York City, that it is an ongoing quest -- and declared Chalmers the winner. What ultimately helped to settle the bet was a study testing two leading hypotheses about the neural basis of consciousness, whose findings were unveiled at the conference.

"It was always a relatively good bet for me and a bold bet for Christof," says Chalmers, who is now co-director of the Center for Mind, Brain and Consciousness at New York University. But he also says this isn't the end of the story, and that an answer will come eventually: "There's been a lot of progress in the field." Consciousness is everything that a person experiences -- what they taste, hear, feel and more. It is what gives meaning and value to our lives, Chalmers says. Despite a vast effort, researchers still don't understand how our brains produce it, however. "It started off as a very big philosophical mystery," Chalmers adds. "But over the years, it's gradually been transmuting into, if not a 'scientific' mystery, at least one that we can get a partial grip on scientifically."

[...] The goal was to set up a series of 'adversarial' experiments to test various hypotheses of consciousness by getting rival researchers to collaborate on the studies' design. "If their predictions didn't come true, this would be a serious challenge for their theories," Chalmers says. The findings from one of the experiments -- which involved several researchers, including Koch and Chalmers -- were revealed on Friday at the ASSC meeting. It tested two of the leading hypotheses: integrated information theory (IIT) and global network workspace theory (GNWT). IIT proposes that consciousness is a 'structure' in the brain formed by a specific type of neuronal connectivity that is active for as long as a certain experience, such as looking at an image, is occurring. This structure is thought to be found in the posterior cortex, at the back of the brain. GNWT, by contrast, suggests that consciousness arises when information is broadcast to areas of the brain through an interconnected network. The transmission, according to the theory, happens at the beginning and end of an experience and involves the prefrontal cortex, at the front of the brain.

Space

Black Hole at Heart of Our Galaxy Is on Crash Course, Space-Time Ripples Reveal (wsj.com) 53

Supermassive black holes all over the universe are merging, a fate that will eventually come for the black hole at the center of our galaxy. From a report: These mysterious cosmic structures at the heart of nearly every galaxy consume light and matter and are impossible to glimpse with traditional telescopes. But now, for the first time, astrophysicists have gathered knowledge directly from these titans, in the form of gravitational waves that ripple through space and time. What they learned suggests that the population of massive black hole pairs that are merging numbers in the hundreds of thousands -- perhaps even millions.

The gravitational waves from these mergers are all contributing to an underlying background hum of the universe that researchers can detect from Earth. The findings, from a collaboration of more than 100 scientists, help confirm what will one day happen to the supermassive black hole at our galaxy's center, known as Sagittarius A*, as it crashes into the black hole at the heart of the Andromeda galaxy. "The Milky Way galaxy is on a collision course with the Andromeda galaxy, and in about 4.5 billion years, the two galaxies are set to merge," said Joseph Simon, a University of Colorado, Boulder, astrophysicist and a member of the North American Nanohertz Observatory for Gravitational Waves, or Nanograv, which helped lead the new work with support from the National Science Foundation.

That merger, he said, will eventually result in the black hole at the center of Andromeda and Sagittarius A* sinking into the center of the newly combined galaxy and forming what is known as a binary system. The results were announced in a series of papers published Wednesday in the Astrophysical Journal Letters. "Before now, we didn't even know if supermassive black holes merged, and now we have evidence that hundreds of thousands of them are merging," said Chiara Mingarelli, a Yale University astrophysicist and a member of Nanograv. The new work could answer questions such as how these black holes grow, and how often their host galaxies merge, the researchers said.
Further reading: The Cosmos Is Thrumming With Gravitational Waves, Astronomers Find.
Businesses

Virgin Galactic Launches Crucial First Commercial Spaceflight (cnbc.com) 30

It is showtime for Virgin Galactic. The spaceflight company founded by billionaire entrepreneur Richard Branson almost two decades ago launched its long-awaited first commercial spaceflight, called "Galactic 01," on Thursday. From a report: Taking off from Spaceport America in New Mexico, the company's spacecraft is being flown by a pair of pilots and carries four passengers: A Virgin Galactic trainer, to oversee the mission from inside the cabin, and its first trio of paying customers. The three paying passengers are members of the Italian Air Force, and the flight carries 13 research payloads onboard. Virgin Galactic's start to commercial service comes after years of delays and setbacks. If "Galactic 01" is successful, the company plans to fly its second mission as soon as August and then aims to begin flying its spacecraft, VSS Unity, once a month.
News

Aspartame Sweetener, Used in Products From Coca-Cola Diet Sodas To Mars' Extra Chewing Gum, Set To Be Declared a Possible Carcinogen (reuters.com) 274

One of the world's most common artificial sweeteners is set to be declared a possible carcinogen next month by a leading global health body, Reuters reported Thursday, citing two sources with knowledge of the process, pitting it against the food industry and regulators. From the report: Aspartame, used in products from Coca-Cola diet sodas to Mars' Extra chewing gum and some Snapple drinks, will be listed in July as "possibly carcinogenic to humans" for the first time by the International Agency for Research on Cancer (IARC), the World Health Organization's (WHO) cancer research arm, the sources said. The IARC ruling, finalised earlier this month after a meeting of the group's external experts, is intended to assess whether something is a potential hazard or not, based on all the published evidence.

It does not take into account how much of a product a person can safely consume. This advice for individuals comes from a separate WHO expert committee on food additives, known as JECFA (the Joint WHO and Food and Agriculture Organization's Expert Committee on Food Additives), alongside determinations from national regulators. However, similar IARC rulings in the past for different substances have raised concerns among consumers about their use, led to lawsuits, and pressured manufacturers to recreate recipes and swap to alternatives. That has led to criticism that the IARC's assessments can be confusing to the public.

NASA

NASA Kills Its X-57 Electric Plane Before It Ever Flies (popsci.com) 43

schwit1 shares a report from Popular Science: NASA said in a conference call with reporters that it would not ever be flying its experimental electric aircraft, the X-57, citing safety concerns that are insurmountable with the time and budget they have for the project. The X-57 program will wind down without the aircraft ever going up into the sky. The project had previously seen challenges. For example, transistor modules in the electrical inverters kept failing and "blowing up" in testing, Sean Clark, the project's principal investigator told Popular Science in January. That problem was solved, Clark said.

The problem that led them to scrap the plan to fly the aircraft stemmed from motors that power the propellers. Clark said today that analysis of the issue is ongoing. "As we got into the detailed analysis and airworthiness assessment of the motors themselves, we found that there were some potential failure modes with the motors mechanically, under flight loads, that we hadn't seen on the ground," he said. "We've got a great design in progress to fix it, it's just [that] it would take too long for us to go through and implement that."

NASA said that the reason behind permanently scrubbing the flight is safety and time. "Unfortunately, we recently discovered a potential failure mode in the propulsion system that we determined to pose an unacceptable risk to the pilot's safety, and the safety of personnel on the ground, during ground tests," Bradley Flick, the director of NASA's Armstrong Flight Research Center in California, said in the call. "Mitigation of that failure would take the project well beyond its planned end at the end of this fiscal year, so NASA has decided to end the project on time without taking the vehicle to flight."

Space

Planet That Shouldn't Exist Found (arstechnica.com) 49

The exoplanet 8 Ursae Minoris b should not exist. It orbits its host star at just half the Earth-Sun distance, and by all indications, the star should have gone through a phase in which it bloated up enough to engulf that entire orbit and then some. Yet 8 Ursae Minoris b definitely appears to exist. From a report: There is a handful of potential explanations, none of them especially likely. The people who discovered the planet are suggesting that it survived because its host star got distracted by swallowing a white dwarf instead. 8 Ursae Minoris b was discovered using the radial velocity method, which watches for changes in a star's light that occur as planets tug the star back and forth as they orbit. This tugging creates a blue shift in the light when the planet is pulling the star in the direction of Earth and a red shift when the star is pulled away from Earth.

But the planet is unlikely to be tugging the star directly toward Earth, so we tend to only measure the component of the star's motion that's in our direction. We'd see the same apparent motion of the star if a light planet's orbit was oriented directly toward Earth or a very heavy planet that has a relatively skewed orbit. At best, radial velocity measurements give us an estimate of the minimum mass of the planet; it could potentially be larger. So we know that, at minimum, 8 Ursae Minoris b is a big planet, at over 1.6 times the mass of Jupiter. It also resides close to its host star, completing a full orbit in just 93 days. That places it at half an Astronomical Unit (AU, the typical distance between Earth and the Sun) from its star.

Observations also hint at a second body orbiting the star at least five AU. The evidence for that is weak given the current data, but it may have a significant role in shaping the system. On its own, there's nothing especially unusual about the 8 Ursae Minoris exosolar system. Where things get weird is when you consider the star at the center of the system.

Mars

NASA Locks 4 Volunteers Into 3D-Printed Virtual 'Mars' For Over a Year (nypost.com) 54

Four volunteers will spend the next 378 days in a simulation of Mars, facing harsh, realistic challenges in tight quarters under NASA's watchful eye in preparation for a real-life mission to the red planet. From a report: Research scientist Kelly Haston, structural engineer Ross Brockwell, emergency medicine physician Nathan Jones and US Navy microbiologist Anca Selariu were locked into the virtual planet at the Johnson Space Center in Houston, Texas, on Sunday as part of the first of a three-year-long simulation study by the space agency. "The knowledge we gain here will help enable us to send humans to Mars and bring them home safely," Grace Douglas, the mission's principal investigator at NASA, said during a briefing.

Nasa 3D-printed the 1,700-square-foot facility, dubbed Crew Health and Performance Exploration Analog -- or CHAPEA. It will be the longest analog mission in the agency's history. The habitat -- named Mars Dune Alpha -- will feature a kitchen, private crew quarters, and two bathrooms, with medical, work, and recreation areas. The crew will be expected to carry out "mission activities," like collecting geological samples, exercising, and practicing personal hygiene and health care, with minimal contact with their family and loved ones, according to NASA. To capture the true essence of life on our neighboring planet, the crew must work through "environmental stressors," including limits on resources, periods of isolation, and equipment failures.

Medicine

First US Malaria Cases Diagnosed In Decades In Florida and Texas (reuters.com) 165

An anonymous reader quotes a report from Reuters: Five cases of malaria have been confirmed in Florida and Texas, the first time the potentially fatal mosquito-borne disease has been locally acquired in the United States in 20 years, the Centers for Disease Control and Prevention said Monday. The four Florida cases, along with one in Texas, have been diagnosed over a period of two months, the agency said. The state of Florida said that its first case was diagnosed on May 26 in Sarasota County, while officials in Texas said on June 23 that a Texas resident who worked outdoors in Cameron County had been diagnosed with the disease.

The CDC said in an alert released Monday that malaria is considered a medical emergency, and that anyone with symptoms should be "urgently evaluated." However, the CDC said that risk of malaria remains low in the United States, and that most cases are acquired when people travel outside of the country. Fully 95% of malaria infections are acquired in Africa, the health agency said. Malaria is caused by five species of a parasite carried by certain female mosquitoes. Symptoms include fever, chills, headache, muscle pain and fatigue. Nausea, diarrhea and vomiting may also appear. Malaria can cause life-threatening damage, including kidney failure, seizures and coma.

Education

Cleaner Accidentally Ruins Decades of US College's Research By Turning Off Freezer (theguardian.com) 224

An anonymous reader quotes a report from The Guardian: A cleaner at a college in New York state accidentally destroyed decades of research by turning off a freezer in order to mute "annoying alarm" sounds. The Rensselaer Polytechnic Institute (RPI), in Troy, is suing the cleaner's employer, alleging improper training. According to a lawsuit filed in the New York supreme court in Rensselaer county earlier this month, the university is seeking more than $1m in damages, the Times Union newspaper reported. "People's behavior and negligence caused all this," Michael Ginsberg, an attorney for RPI, told the Times Union. "Unfortunately, they wiped out 25 years of research."

The cleaner, who is not named in the lawsuit, was employed by Daigle Cleaning Systems and worked at RPI for several months in 2020, when the incident occurred. The lab freezer contained several cultures that were part of a research project on photosynthesis headed by the biology and chemistry professor KV Lakshmi, the BBC reported. The cultures were usually stored at -112F (-80C). On September 14, 2020, days before the freezer was unplugged, an alarm indicated that the freezer temperature was fluctuating, the lawsuit says, adding that the specimens in the freezer were still viable at that point. Covid restrictions at the time meant repairs could not be made for a week. Lab officials took precautions to preserve the cultures and explain the alarm, posting a sign explaining where the noise was coming from and how to mute it. Lakshmi also installed a lock box on the freezer's outlet and socket to stop anyone unplugging it.

But on September 17, the Daigle Cleaning Systems employee turned off the circuit breaker, causing the temperature of the freezer to rise. The next day, lab officials discovered the samples were unsalvageable. "[A] majority of specimens were compromised, destroyed and rendered unsalvageable demolishing more than 20 years of research," the lawsuit says. In an interview with university officials, the cleaner said he thought he was turning the circuit breaker on after hearing the alarms. "At the end of the interview, he still did not appear to believe he had done anything wrong but was just trying to help," the lawsuit says, saying the cleaner made an "error" when reading the panel.

Science

Scientists Debut Lab Models of Human Embryos (nytimes.com) 29

Carl Zimmer writes in The New York Times: In its first week, a fertilized human egg develops into a hollow ball of 200 cells and then implants itself on the wall of the uterus. Over the next three weeks, it divides into the distinct tissues of a human body. And those crucial few weeks remain, for the most part, a black box. "We know the basics, but the very fine details we just don't know," said Jacob Hanna, a developmental biologist at the Weizmann Institute of Science in Israel. Dr. Hanna and a number of other biologists are trying to uncover those details by creating models of human embryos in the lab. They are coaxing stem cells to organize themselves into clumps that take on some of the crucial hallmarks of real embryos.

This month, Dr. Hanna's team in Israel, as well as groups in Britain, the United States and China, released reports on these experiments. The studies, while not yet published in scientific journals, have attracted keen interest from other scientists, who have been hoping for years that such advances could finally shed light on some of the mysteries of early human development. Ethicists have long cautioned that the advent of embryo models would further complicate the already complicated regulation of this research. But the scientists behind the new work were quick to stress that they had not created real embryos and that their clusters of stem cells could never give rise to a human being. "We do it to save lives, not create it," said Magdalena Zernicka-Goetz, a developmental biologist at the University of Cambridge and the California Institute of Technology, who led another effort. [...]

If scientists can create close, reliable models of embryos, they will be able to run large-scale experiments to test potential causes of pregnancy failures, such as viral infections and genetic mutations. The models could lead to other medical advances too, noted Insoo Hyun, a member of the Harvard Medical School Center for Bioethics who was not involved in the new studies. "Once you get the embryo models in place and you can rely on them, that can be an interesting way to screen drugs that women take when they're pregnant," he said. "That would be an enormous benefit." Dr. Hanna [...] also saw a possibility of using embryo models as a new form of stem-cell treatment for diseases such as cancer.

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