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Biotech

A California Boy Was Kidnapped from a Park in 1951. He's Just Been Found Alive (sfgate.com) 132

An anonymous reader shared this story from SFGate: A boy who was kidnapped from an Oakland playground in 1951 has been found alive on the East Coast, a remarkable resolution to a mystery that has haunted his family for over half a century.

On February 21, 1951, 6-year-old Luis Armando Albino was playing with his older brother Roger at Jefferson Square Park. The boys had recently immigrated with their mother and four other siblings from Puerto Rico... That afternoon, Luis and 10-year-old Roger walked down the block from their home at 730 Brush Street to play in the park. They were approached by a woman in her 30s, wearing a green bandana over her hair, who began chatting with Luis in Spanish. She promised she would buy him candy if he came along with her, and little Luis agreed to join her. Wary, Roger trailed the pair for a while before returning home to alert an adult to the strange encounter. Oakland police were called by frantic family members and a search was immediately launched...

Antonia [the boy's mother] was convinced her son was alive. "She came once a week, then once a month, then at least once a year, to see the shake of the head, to have the answer 'no' translated for her although she could read it in the officers' faces," the Oakland Tribune wrote in 1966...

Decades passed.

In 2020, Luis' niece, Alida Alequin, took a DNA test on a whim, the Mercury News reported. The service returned several possible family members to the Oakland woman. One of them was a man who Alequin had never met. After some internet sleuthing, she began to suspect this man might be the missing uncle she'd heard so much about. She reached out to the man but didn't hear back.

Earlier this year, Alequin tried again. Armed with photos, she took her evidence to the Oakland Police Department's missing persons unit. In short order, the FBI and California Department of Justice were also investigating Alequin's lead. They discovered the man was living on the East Coast, had worked as a firefighter and served two tours in Vietnam with the Marine Corps. This week, the Mercury News first reported that a DNA test confirmed what Alequin suspected: This was Luis Albino.

In June, Luis flew to California to reunite with his family, among them his devoted brother Roger... For over 70 years, he lived on the East Coast believing he was the son of another couple....

When Luis met Alequin for the first time this summer, he held her in an embrace. "Thank you," he said, "for finding me."

Science

Vaporizing Plastics Recycles Them Into Nothing But Gas, Researchers Find (arstechnica.com) 54

Polypropylene and polyethylene plastics "can be recycled," reports Ars Technica. But as "polyolefin" polymers, "the process can be difficult and often produces large quantities of the greenhouse gas methane.

"Now, researchers at the University of California, Berkeley have come up with a method of recycling these polymers that uses catalysts that easily break their bonds, converting them into propylene and isobutylene, which are gasses at room temperature. Those gasses can then be recycled into new plastics..." [T]he previous catalysts were expensive metals that did not remain pure long enough to convert all of the plastic into gas. Using sodium on alumina followed by tungsten oxide on silica proved much more economical and effective, even though the high temperatures required for the reaction added a bit to the cost. In both plastics, exposure to sodium on alumina broke each polymer chain into shorter polymer chains and created breakable carbon-carbon double bonds at the ends. The chains continued to break over and over.

Both then underwent a second process known as olefin metathesis. They were exposed to a stream of ethylene gas flowing into a reaction chamber while being introduced to tungsten oxide on silica, which resulted in the breakage of the carbon-carbon bonds. The reaction breaks all the carbon-carbon bonds in polyethylene and polypropylene, with the carbon atoms released during the breaking of these bonds ending up attached to molecules of ethylene... The entire chain is catalyzed until polyethylene is fully converted to propylene, and polypropylene is converted to a mixture of propylene and isobutylene. This method has high selectivity — meaning it produces a large amount of the desired product.

That means propylene derived from polyethylene, and both propylene and isobutylene derived from polypropylene. Both of these chemicals are in high demand, since propylene is an important raw material for the chemical industry, while isobutylene is a frequently used monomer in many different polymers, including synthetic rubber and a gasoline additive.

"Because plastics are often mixed at recycling centers, the researchers wanted to see what would happen if polypropylene and polyethylene underwent isomerizing ethenolysis together," the article adds. "The reaction was successful, converting the mixture into propylene and isobutylene, with slightly more propylene than isobutylene." The reaction worked, even if there were contaminants from other plastics. And "When the research team increased the scale of the experiment, it produced the same yield, which looks promising for the future...."

The researchers hope this some day could reduce the demand for chemicals derived from fossil fuels.

Thanks to Slashdot reader echo123 for sharing the article.
NASA

How NASA Could Find Evidence of Life on Another Planet Within 25 Years (washingtonpost.com) 131

"In all likelihood, in the next 25 years, we'll find evidence of life on another planet..." begins a new essay by author Dave Eggers in the Washington Post.

"In more than a dozen conversations with some of the best minds in astrophysics, I did not meet anyone who was doubtful about finding evidence of life elsewhere — most likely on an exoplanet beyond our solar system. It was not a matter of if. It was a matter of when." [A]ll evidence points to us getting closer, every year, to identifying moons in our solar system, or exoplanets beyond it, that can sustain life. And if we don't find conditions for life on the moons near us, we'll find it on exoplanets — that is, planets outside our solar system. Within the next few decades, we'll likely find an exoplanet that has an atmosphere, that has water, that has carbon and methane and oxygen. Or some combination of those things.

And thus, the conditions for life. In a few years, NASA will launch the Nancy Grace Roman Space Telescope, which will have a panoramic field of vision a hundred times greater than the Hubble Space Telescope. And on the Nancy Grace Roman Space Telescope — we'll call it Roman from here on out — there will be a coronagraph, a device designed to perform something called, beautifully, starlight suppression. Starlight suppression is the blocking of the rays of a faraway star so that we can see behind it and around it. Once we can master starlight suppression, with Roman and NASA's next astrophysics flagship, the Habitable Worlds Observatory, we'll find the planets where life might exist.

To recap: For thousands of years, humans have wondered whether life is possible elsewhere in the universe, and now we're within striking distance of being able to say not only yes, but here.

And yet this is not front-page news. I didn't really know how close we were to this milestone until I visited the Jet Propulsion Laboratory in Pasadena, Calif., on a hot and dry day in June...

Eggers' article is part of an ongoing series called "Who is government?" (For the series Michael Lewis also profiled the uncelebrated number-crunchers at the U.S. Department of Labor, while Casey Cep wrote about the use of DNA to identify the remains of World War II soldiers for America's Veteran Affairs' department's.) But this week Eggers wrote that the work being done at NASA's Jet Propulsion Laboratory "is the most inspiring research and exploration being done by any humans on our planet..."

"No billionaires will fund work like this because there's no money in it. This is government-funded research to determine how the universe was created and whether we are alone in it. If NASA and JPL were not doing it, it would not be done."

Eggers emphasizes later that "doesn't mean it's intelligent life, or even semi-intelligent life. It could be bacteria, or some kind of interstellar sea cucumber. But whatever form it takes, we are close to finding it..."
Medicine

America's FTC Sues Insulin Middlemen Who 'Artificially Inflated' Drug Price (npr.org) 124

Friday America's Federal Trade Commission brought action against three companies for "anticompetitive and unfair" practices "that have artificially inflated the list price of insulin."

For years, many of the millions of Americans who need insulin to survive "have been forced to pay exorbitant prices for a product that's inexpensive to make," writes NPR. "Now, the federal government is targeting one part of the system behind high insulin prices." While out-of-pocket costs have gone down for many people to $35 a month, questions remain on how the drug became so expensive in the first place. In a new lawsuit filed Friday, the Federal Trade Commission said it's going after one link in the chain: pharmacy benefit managers. The FTC brought action against the top pharmacy benefit managers (PBMs) — CVS Health's Caremark Rx, Cigna's Express Scripts, and United Health Group's OptumRx — saying the companies created a "perverse drug rebate system" that artificially inflates the cost of insulin. If the suit is successful, it could further drive down costs for patients at the pharmacy counter.

PBMs are essentially the middlemen between drug manufacturers and insurance providers. Their job is to reduce drug prices. But the process is complex and opaque, and critics say they're actually driving prices up for patients. The FTC said a big issue is that PBMs' revenue is tied to rebates and fees — which are based on a percentage of a drug's list price. Essentially, in the case of insulin, when the drug costed more, it generated higher rebates and fees for PBMs. "Even when lower list price insulins became available that could have been more affordable for vulnerable patients, the PBMs systemically excluded them in favor of high list price, highly rebated insulin products," the FTC said in a press release on Friday.

The three PBMs named in the FTC lawsuit make up about 80% of the market. According to the suit, the PBMs collected billions of dollars in rebates and fees while insulin became increasingly unaffordable. Over the last two decades, the cost of the lifesaving drug shot up 600% — forcing many Americans with diabetes to ration their medication and jeopardize their health. In 2019, one 1 of 4 insulin patients was unable to afford their medication, according to the FTC. Some people have died.

The FTC's statement says the companies "have abused their economic power by rigging pharmaceutical supply chain competition in their favor, forcing patients to pay more for life-saving medication... While PBM respondents collected billions in rebates and associated fees according to the complaint, by 2019 one out of every four insulin patients was unable to afford their medication..."

"[A]ll drug manufacturers should be on notice that their participation in the type of conduct challenged here raises serious concerns, and that the Bureau of Competition may recommend suing drug manufacturers in any future enforcement actions."
Space

Could We Turn the Sun Into an Extremely Powerful Telescope? (space.com) 65

It's hypothetically capable of "delivering an exquisite portrait of the detailed surface features of any exoplanet within 100 light-years..." writes Space.com.

"It would be better than any telescope we could possibly build in any possible future for the next few hundred years..." While the sun may not look like a traditional lens or mirror, it has a lot of mass. And in Einstein's theory of general relativity, massive objects bend space-time around them. Any light that grazes the surface of the sun gets deflected and, instead of continuing in a straight line, heads toward a focal point, together with all the other light that grazes the sun at the same time... The "solar gravitational lens" leads to an almost unbelievably high resolution. It's as if we had a telescope mirror the width of the entire sun. An instrument positioned at the correct focal point would be able to harness the gravitational warping of the sun's gravity to allow us to observe the distant universe with a jaw-dropping resolution of 10^-10 arcseconds. That's roughly a million times more powerful than the Event Horizon Telescope.

Of course, there are challenges with using the solar gravitational lens as a natural telescope. The focal point of all this light bending sits 542 times greater than the distance between Earth and the sun. It's 11 times the distance to Pluto, and three times the distance achieved by humanity's most far-flung spacecraft, Voyager 1, which launched in 1977. So not only would we have to send a spacecraft farther than we ever have before, but it would have to have enough fuel to stay there and move around. The images created by the solar gravitational lens would be spread out over tens of kilometers of space, so the spacecraft would have to scan the entire field to build up a complete mosaic image.

Plans to take advantage of the solar lens go back to the 1970s. Most recently, astronomers have proposed developing a fleet of small, lightweight cubesats that would deploy solar sails to accelerate them to 542 AU. Once there, they would slow down and coordinate their maneuvers, building up an image and sending the data back to Earth for processing...

The telescope already exists — we just have to get a camera in the right position.

Thanks to Tablizer (Slashdot reader #95,088) for sharing the article.
Science

Scientists Again Link Covid Pandemic Origin to Wuhan Market Animals (msn.com) 131

The Washington Post reports: An international team of scientists published a peer-reviewed paper Thursday saying genetic evidence indicates the coronavirus pandemic most likely originated with a natural spillover from an animal or animals sold in a market in Wuhan, China, where many of the first human cases of covid-19 were identified. The paper, which appears in the journal Cell, does not claim to prove conclusively that the pandemic began in the Huanan Seafood Wholesale Market, and it is unlikely to end the acrimonious and politicized debate over the coronavirus's origin... "The results we see are consistent with infected animals, but we cannot prove that they were," said Florence Débarre, an evolutionary biologist at the French National Center for Scientific Research and a co-author of the new paper...

Many of the 23 authors of the paper are known to have long supported a market origin for the virus. In an informal report in March 2023, they presented a central feature of the genetic data — the confirmation that animals potentially capable of triggering a pandemic were in the market... The new paper in Cell is longer, more comprehensive, probes a broader range of questions, and includes more data from the market and early-patient cases than the international team's informal 2023 report, Débarre said. Both the earlier and the new reports document that traces of the virus were found clustered in a section of the Huanan Seafood Wholesale Market where genetic traces of animals were also found. Several of those species — raccoon dogs, rabbits and dogs — are known to be susceptible to infection with SARS-CoV-2, the virus that causes covid. Raccoon dogs have also been shown experimentally to be capable of transmitting the virus. A significant element of the new paper is an analysis of when the pandemic began. Scientists can study mutations of the coronavirus, which evolves at a relatively steady rate, to estimate when the millions of genomes deposited in databases had the most recent common ancestor. That genetic evidence points to mid-November 2019 as the most likely time the virus spilled into humans and began spreading, and there could have been two or more spillover events, the researchers said.

"The timing of the origin of the market outbreak is genetically indistinguishable from the timing of the origin of the pandemic as a whole," the report states. There are many independent lines of evidence pointing to the market as the epicenter of the pandemic, said Kristian Andersen, an infectious-disease researcher at Scripps Research in La Jolla, Calif., and a co-author of the report in Cell. No previous virus spillover has been so well-documented, he said. "Of any previous outbreak, pandemic, you name it, we don't have this level of granularity," he said. "We can narrow it down to a single market, and narrow it down to a section in that market, and maybe even narrow it down to a single stall in that market. That is mind-boggling...." The genetic evidence, the new report contends, supports the hypothesis that SARS-CoV-2 emerged in the same way that SARS-CoV-1 — which sickened people in 2002-2003 but was extinguished before it could cause a full-blown pandemic — is widely believed to have started, from animals sold in a market.

The authors contend the world needs to take more aggressive action to shut down the illegal trade in wildlife to lower the risk of another catastrophic pandemic... There is no evidence that the virus, or its progenitor, was inside a laboratory before the outbreak.... "To the question — Did it come from a lab or come from a market? — I think we already knew the answer to that," Andersen said. "Yep, it's the market. It's natural, as we've previously seen happen."

One co-author posted a summary on X.com "If you don't want to read the papers."
  • "Early cases centered around the market (not a lab)"
  • "Environmental swabs that tested positive for SARS-CoV-2 clustered in the corner of the market where animals were sold."
  • "There were 2 lineages of SARS2 that spilled over separately at Huanan."

Science

Researcher Wins Award For Debunking Longer Life Expectancies in 'Blue Zones' (theconversation.com) 63

Slashdot first covered Saul Justin Newman's work in 2019.

Now a senior research fellow at the Centre for Longitudinal Studies at University College London, Newman was recognized last week for research finding that most claims of people living over 105 are wrong. Newman's research was honored with an Ig Nobel Prize (awarded for research that makes people "laugh then think") — which led to a thought-provoking interview in the Conversation: Newman: In general, the claims about how long people are living mostly don't stack up. I've tracked down 80% of the people aged over 110 in the world (the other 20% are from countries you can't meaningfully analyse). Of those, almost none have a birth certificate. In the U.S. there are over 500 of these people; seven have a birth certificate. Even worse, only about 10% have a death certificate.

The epitome of this is blue zones, which are regions where people supposedly reach age 100 at a remarkable rate. For almost 20 years, they have been marketed to the public. They're the subject of tons of scientific work, a popular Netflix documentary, tons of cookbooks about things like the Mediterranean diet, and so on. Okinawa in Japan is one of these zones. There was a Japanese government review in 2010, which found that 82% of the people aged over 100 in Japan turned out to be dead. The secret to living to 110 was, don't register your death. [Newman says later that "In Okinawa, the best predictor of where the centenarians are is where the halls of records were bombed by the Americans during the war..."] The Japanese government has run one of the largest nutritional surveys in the world, dating back to 1975. From then until now, Okinawa has had the worst health in Japan. They've eaten the least vegetables; they've been extremely heavy drinkers....

With the Greeks, by my estimates at least 72% of centenarians were dead, missing or essentially pension-fraud cases... According to the Greek minister that hands out the pensions, over 9,000 people over the age of 100 are dead and collecting a pension at the same time. In Italy, some 30,000 "living" pension recipients were found to be dead in 1997. Regions where people most often reach 100-110 years old are the ones where there's the most pressure to commit pension fraud, and they also have the worst records.

So what's the truth on human longevity? "The question is so obscured by fraud and error and wishful thinking that we just do not know," Newman answers (suggesting physicists "develop a measure of human age that doesn't depend on documents.") In the end the truth may be much more ordinary. "Longevity is very likely tied to wealth. Rich people do lots of exercise, have low stress and eat well."

Newman also says that if the scientific community won't acknowledge their errors during his lifetime, "I guess I'll just get someone to pretend I'm still alive until that changes."

Thanks to long-time Slashdot reader schwit1 for sharing the news.
Science

CERN To Expel Hundreds of Russian Scientists (semafor.com) 127

An anonymous reader shares a report: CERN, the European particle-physics collaboration that operates the Large Hadron Collider, will expel hundreds of Russian-affiliated scientists from its laboratories. The Geneva-based organization decided to cut ties with Moscow after Russia's 2022 invasion of Ukraine, ending nearly 60 years of collaboration, and the agreements are now lapsing.
Moon

Earth Will Get a Second 'Mini-Moon' For 2 Months This Year 32

A small asteroid, 2024 PT5, will temporarily become a mini-moon for Earth, orbiting in a horseshoe shape from September 29 to November 25, 2024. CBS News reports: Researchers at the Asteroid Terrestrial-impact Last Alert System, an asteroid monitoring system funded by NASA, spotted the asteroid using an instrument in Sutherland, South Africa and labeled it 2024 PT5. Scientists from the Universidad Complutense de Madrid have tracked the asteroid's orbit for 21 days and determined its future path. 2024 PT5 is from the Arjuna asteroid belt, which orbits the sun, according to their study published in Research Notes of the AAs. But Earth's gravitational pull will draw 2024 PT5 towards it and, much like our moon, it will orbit our planet -- but only for 56.6 days. 2024 PT5, which is larger than some of the other mini-moons, will also return to Earth's orbit -- in 2055. [...]

The study's lead author Carlos de la Fuente Marcos told Space.com the mini-moon will be too small to see with amateur telescopes or binoculars but professional astronomers with stronger tools will be able to spot it.
AI

AI Tool Cuts Unexpected Deaths In Hospital By 26%, Canadian Study Finds (www.cbc.ca) 77

An anonymous reader quotes a report from CBC News: Inside a bustling unit at St. Michael's Hospital in downtown Toronto, one of Shirley Bell's patients was suffering from a cat bite and a fever, but otherwise appeared fine -- until an alert from an AI-based early warning system showed he was sicker than he seemed. While the nursing team usually checked blood work around noon, the technology flagged incoming results several hours beforehand. That warning showed the patient's white blood cell count was "really, really high," recalled Bell, the clinical nurse educator for the hospital's general medicine program. The cause turned out to be cellulitis, a bacterial skin infection. Without prompt treatment, it can lead to extensive tissue damage, amputations and even death. Bell said the patient was given antibiotics quickly to avoid those worst-case scenarios, in large part thanks to the team's in-house AI technology, dubbed Chartwatch. "There's lots and lots of other scenarios where patients' conditions are flagged earlier, and the nurse is alerted earlier, and interventions are put in earlier," she said. "It's not replacing the nurse at the bedside; it's actually enhancing your nursing care."

A year-and-a-half-long study on Chartwatch, published Monday in the Canadian Medical Association Journal, found that use of the AI system led to a striking 26 percent drop in the number of unexpected deaths among hospitalized patients. The research team looked at more than 13,000 admissions to St. Michael's general internal medicine ward -- an 84-bed unit caring for some of the hospital's most complex patients -- to compare the impact of the tool among that patient population to thousands of admissions into other subspecialty units. "At the same time period in the other units in our hospital that were not using Chartwatch, we did not see a change in these unexpected deaths," said lead author Dr. Amol Verma, a clinician-scientist at St. Michael's, one of three Unity Health Toronto hospital network sites, and Temerty professor of AI research and education in medicine at University of Toronto. "That was a promising sign."

The Unity Health AI team started developing Chartwatch back in 2017, based on suggestions from staff that predicting deaths or serious illness could be key areas where machine learning could make a positive difference. The technology underwent several years of rigorous development and testing before it was deployed in October 2020, Verma said. Dr. Amol Verma, a clinician-scientist at St. Michael's Hospital who helped lead the creation and testing of CHARTwatch, stands at a computer. "Chartwatch measures about 100 inputs from [a patient's] medical record that are currently routinely gathered in the process of delivering care," he explained. "So a patient's vital signs, their heart rate, their blood pressure ... all of the lab test results that are done every day." Working in the background alongside clinical teams, the tool monitors any changes in someone's medical record "and makes a dynamic prediction every hour about whether that patient is likely to deteriorate in the future," Verma told CBC News.

Medicine

FDA Grants Neuralink With Breakthrough Device Tag For 'Blindsight' Implant 14

Neuralink said on Tuesday it has received the FDA's "breakthrough device" designation for its experimental implant aimed at restoring vision. Called Blindsight, the device "will enable even those who have lost both eyes and their optic nerve to see," said Neuralink founder Elon Musk. Reuters reports: The FDA's breakthrough tag is given to certain medical devices that provide treatment or diagnosis of life-threatening conditions. It is aimed at speeding up development and review of devices currently under development. Neuralink did not immediately respond to a request seeking details about when it expects the Blindsight device to move into human trials.
Medicine

New Research Finds Microplastics In the Brain's Olfactory Bulb 44

An anonymous reader quotes a report from NBC News: Scientists in Brazil found microplastics in the brain tissue of cadavers, according to a new study published Monday in the journal JAMA Network Open. Mounting research over the last few years has found microplastics in nearly every organ in the body, as well as in the bloodstream and in plaque that clogs arteries. Whether these ubiquitous pollutants can reach the human brain has been a primary concern for scientists. The latest research looked at a part of the brain called the olfactory bulb, which processes information about smell. Humans have two olfactory bulbs, one above each nasal cavity. Connecting the olfactory bulb and the nasal cavity is the olfactory nerve.

Some researchers worry the olfactory pathway may also be an entry point for microplastics getting into the brain, beyond the olfactory bulb. "Previous studies in humans and animals have shown that air pollution reaches the brain, and that particles have been found in the olfactory bulb, which is why we think the olfactory bulb is probably one of the first points for microplastics to reach the brain," said lead study author Dr. Thais Mauad, an associate professor of pathology at the University of Sao Paulo Medical School in Brazil.

Mauad and her team took samples of olfactory bulb tissue from 15 cadavers of people who died between the ages of 33 and 100. Samples from eight of the cadavers contained microplastics -- tiny bits of plastic that ranged from 5.5 micrometers to 26.4 micrometers in size. In total, the researchers found 16 plastic fibers and particles in the tissues. The smallest were slimmer than the diameter of a human red blood cell, which measures about 8 micrometers. The most common type of plastic they found was polypropylene, followed by polyamide, nylon and polyethylene vinyl acetate. "The nose is a major point of defense to keep particles and dust out of the lungs," Campen wrote in an email. "So seeing some plastics in the olfactory system, especially given how they are being found everywhere else in the body, is completely expected." [...] "There is evidence that very small airborne particles can move to the brain via the olfactory bulb, but this is not known to be a major route of trafficking material to the brain," Campen said.
Campen notes it's more likely that nanoplastics enter the brain through the bloodstream, which picks up plastic bits from the lungs or digestive tract, rather than the olfactory bulb. "However, it's extremely difficult for particles, even those in pharmaceuticals, to enter the brain through the blood," notes NBC News. "That's because the brain is surrounded by a semipermeable membrane called the blood-brain barrier."
Medicine

Apple Watch Sleep Apnea Detection Gets FDA Approval 31

The FDA has approved sleep apnea detection on the Apple Watch Series 9, Series 10, and Watch Ultra 2. "The green light comes four days ahead of the Series 10's September 20 release date," notes TechCrunch. From the report: The feature, announced at last week's iPhone 16 event, will arrive as part of the imminent watchOS 11 release. Once enabled, it requires 10 nights of sleep tracking data spread out over a 30-day span to determine whether a user may have the condition. During that time, it also offers insights into nightly sleeping disturbances, utilizing the on-board accelerometer.

The FDA classes the feature as an "over-the-counter device to assess risk of sleep apnea." Apple is quick to note that the addition is not a diagnostic tool. Rather, it will prompt users to seek a formal diagnosis from a healthcare provider. The condition, which causes breathing to become shallower or repeatedly stop during the night, is associated with a variety of different symptoms. The Mayo Clinic notes that it can cause insomnia, headaches, daytime sleepiness, and other longer-term conditions.
Science

Nobel Prize-Winner Tallies Two More Retractions, Bringing Total To 13 (retractionwatch.com) 30

Retraction Watch: A Nobel prize-winning genetics researcher has retracted two more papers, bringing his total to 13. Gregg Semenza, a professor of genetic medicine and director of the vascular program at Johns Hopkins' Institute for Cell Engineering in Baltimore, shared the 2019 Nobel prize in physiology or medicine for "discoveries of how cells sense and adapt to oxygen availability." Since pseudonymous sleuth Claire Francis and others began using PubPeer to point out potential duplicated or manipulated images in Semenza's work in 2019, the researcher has retracted 12 papers. A previous retraction from 2011 for a paper co-authored with Naoki Mori -- who with 31 retractions sits at No. 25 on our leaderboard -- brings the total to 13.
NASA

NASA To Develop Lunar Time Standard for Exploration Initiatives (nasa.gov) 27

NASA will coordinate with U.S. government stakeholders, partners, and international standards organizations to establish a Coordinated Lunar Time (LTC) following a policy directive from the White House in April. From a report: The agency's Space Communication and Navigation (SCaN) program is leading efforts on creating a coordinated time, which will enable a future lunar ecosystem that could be scalable to other locations in our solar system. The lunar time will be determined by a weighted average of atomic clocks at the Moon, similar to how scientists calculate Earth's globally recognized Coordinated Universal Time (UTC). Exactly where at the Moon is still to be determined, since current analysis indicates that atomic clocks placed at the Moon's surface will appear to 'tick' faster by microseconds per day. A microsecond is one millionth of a second. NASA and its partners are currently researching which mathematical models will be best for establishing a lunar time. To put these numbers into perspective, a hummingbird's wings flap about 50 times per second. Each flap is about .02 seconds, or 20,000 microseconds. So, while 56 microseconds may seem miniscule, when discussing distances in space, tiny bits of time add up.
Space

Stephen Hawking Was Wrong - Extremal Black Holes Are Possible (quantamagazine.org) 44

"Even black holes have edge cases," writes Astronomy magazine contributing editor Steve Nadis, in an article in Quanta magazine (republished today by Wired): Black holes rotate in space. As matter falls into them, they start to spin faster; if that matter has charge, they also become electrically charged. In principle, a black hole can reach a point where it has as much charge or spin as it possibly can, given its mass. Such a black hole is called "extremal" — the extreme of the extremes. These black holes have some bizarre properties. In particular, the so-called surface gravity at the boundary, or event horizon, of such a black hole is zero. "It is a black hole whose surface doesn't attract things anymore," said Carsten Gundlach, a mathematical physicist at the University of Southampton. But if you were to nudge a particle slightly toward the black hole's center, it would be unable to escape.

In 1973, the prominent physicists Stephen Hawking, James Bardeen and Brandon Carter asserted that extremal black holes can't exist in the real world — that there is simply no plausible way that they can form. Nevertheless, for the past 50 years, extremal black holes have served as useful models in theoretical physics. "They have nice symmetries that make it easier to calculate things," said Gaurav Khanna of the University of Rhode Island, and this allows physicists to test theories about the mysterious relationship between quantum mechanics and gravity. Now two mathematicians have proved Hawking and his colleagues wrong. The new work — contained in a pair of recent papers by Christoph Kehle of the Massachusetts Institute of Technology and Ryan Unger of Stanford University and the University of California, Berkeley — demonstrates that there is nothing in our known laws of physics to prevent the formation of an extremal black hole.

Their mathematical proof is "beautiful, technically innovative and physically surprising," said Mihalis Dafermos, a mathematician at Princeton University (and Kehle's and Unger's doctoral adviser). It hints at a potentially richer and more varied universe in which "extremal black holes could be out there astrophysically," he added. That doesn't mean they are. "Just because a mathematical solution exists that has nice properties doesn't necessarily mean that nature will make use of it," Khanna said. "But if we somehow find one, that would really [make] us think about what we are missing." Such a discovery, he noted, has the potential to raise "some pretty radical kinds of questions." Before Kehle and Unger's proof, there was good reason to believe that extremal black holes couldn't exist.

Hawking, Bardeen, and Carter believed there was no way an extremal black hole could form, according to the article, and "in 1986, a physicist named Werner Israel seemed to put the issue to rest."

But the two mathematicians, studying the formation of electrically charged black holes, stumbled into a counterexample — and along the way "also constructed two other solutions to Einstein's equations of general relativity that involved different ways of adding charge to a black hole. Having disproved Bardeen, Carter and Hawking's hypothesis in three different contexts, the work should leave no doubt, Unger said... "This is a beautiful example of math giving back to physics," said Elena Giorgi, a mathematician at Columbia University....

In the meantime, a better understanding of extremal black holes can provide further insights into near-extremal black holes, which are thought to be plentiful in the universe. "Einstein didn't think that black holes could be real [because] they're just too weird," Khanna said. "But now we know the universe is teeming with black holes."

For similar reasons, he added, "we shouldn't give up on extremal black holes. I just don't want to put limits on nature's creativity."

Space

SpaceX's Polaris Dawn Crew Returns to Earth After Historic Spacewalk (cnn.com) 27

"It is with great relief that I welcome you home!" SpaceX COO Gwynne Shotwell posted on X. "This mission was even more extraordinary than I anticipated."

"SpaceX's Polaris Dawn crew is home," reports CNN, "capping off a five-day mission to orbit — which included the world's first commercial spacewalk — by splashing down in the Gulf of Mexico." The Crew Dragon capsule carrying four astronauts landed off the coast of Dry Tortugas, Florida, at 3:37 a.m. ET Sunday.

The Polaris Dawn mission made history as it reached a higher altitude than any human has traveled in five decades. [870 miles (1,400 kilometers) — beating the 853-mile record set in 1966 by NASA's Gemini 11 mission.] A spacewalk conducted early Thursday morning also marked the first time such an endeavor has been completed by a privately funded and operated mis.sion.

But returning to Earth is among the most dangerous stretches of any space mission. To safely reach home, the Crew Dragon capsule carried out what's called a "de-orbit burn," orienting itself as it prepared to slice through the thickest part of Earth's atmosphere. The spacecraft then reached extremely hot temperatures — up to 3,500 degrees Fahrenheit (1,900 degrees Celsius) — because of the pressure and friction caused by hitting the air while still traveling around 17,000 miles per hour (27,000 kilometers per hour). The crew, however, should have remained at comfortable temperatures, protected by the Crew Dragon's heat shield, which is located on the bottom of the 13-foot-wide (4-meter-wide) capsule. Dragging against the air began to slow the vehicle down before the Crew Dragon deployed parachutes that further decelerated its descent. Having hit the ocean, the spacecraft briefly bobbed around in the water until rescue crews waiting nearby hauled it out of the ocean and onto a special boat, referred to as the "Dragon's nest." Final safety checks took place there before the crew disembarked from the capsule and began the journey back to dry land.

You can watch video of the splashdown on YouTube.

While in space, the crew performed 40 science experiments and research, according to the article. "Gillis, a trained violinist, also brought her instrument along for the mission and delivered a rendition of 'Rey's Theme' from "Star Wars: The Force Awakens." (Slashdot reader SuperKendall points out that the "Rey's Theme" rendition "was not just the astronaut playing violin in space, but was in conjunction with young adult orchestras around the world.")

SpaceX's COO said the performance "made me tear up. Thank you all for taking this journey."
Earth

Earthquake Scientists Finally Explain 9-Day Global 'Unidentified Seismic Object' (msn.com) 58

It was one year ago that "an odd seismic signal appeared at scientific stations around the globe," reports the Washington Post. "A day passed, and the slow tremor still reverberated. When it continued for a third day, scientists worldwide began assembling..." Some initially thought the seismic instruments recording the signal were broken, but that was quickly nixed. Maybe it was a new volcano emerging before their eyes, others said. One jokingly ruled out an alien party. As theories were checked off, the scientists dubbed the signal an "Unidentified Seismic Object," or USO... Nine days later, the vibrations greatly dissipated. But the mystery of the USO lasted much longer.

A year later, the puzzle has been solved, according to a study published in the journal Science on Thursday. It took about 70 people from 15 different countries and more than 8,000 exchanged messages (long enough for a 900-page detective novel) to crack the case. The short answer: A mega-tsunami created waves that sloshed back and forth in a fjord in Greenland, creating vibrations that traveled around the world.

Extra heat from global warming "thinned a glacier in eastern Greenland over time so much that it could no longer support the mountain rock above it," according to the article. A mile-long avalanche "plunged into the Dickson Fjord, triggering a 650-foot-high tsunami — one of the highest seen in recent history." Like the rhythmic waves in a bathtub, "the mega-tsunami wave traveled back and forth in the inlet," which "radiated seismic waves globally, shaking the planet for nine days before it petered out."

In August a German research team had studied the megatsunami, concluding that climate change was speeding the melt of Greenland's glaciers and increasing the chance of landslide-driven megatsunamis. The article reports that an author of that study said when comparing it to this one, "The methods chosen by the teams are different, but the results agree well."
NASA

Underfunded, Aging NASA May Be On Unsustainable Path, Report Warns (msn.com) 119

More details on that report about NASA from the Washington Post: NASA is 66 years old and feeling its age. Brilliant engineers are retiring. Others have fled to higher-paying jobs in the private space industry. The buildings are old, their maintenance deferred. The Apollo era, with its huge taxpayer investment, is a distant memory. The agency now pursues complex missions on inadequate budgets. This may be an unsustainable path for NASA, one that imperils long-term success. That is the conclusion of a sweeping report, titled "NASA at a Crossroads," written by a committee of aerospace experts and published Tuesday by the National Academies of Sciences, Engineering and Medicine. The report suggests that NASA prioritizes near-term missions and fails to think strategically. In other words, the space agency isn't sufficiently focused on the future.

NASA's intense focus on current missions is understandable, considering the unforgiving nature of space operations, but "one tends to neglect the probably less glamorous thing that will determine the success in the future," the report's lead author, Norman Augustine, a retired Lockheed Martin chief executive, said Tuesday. He said one solution for NASA's problems is more funding from Congress. But that may be hard to come by, in which case, he said, the agency needs to consider canceling or delaying costly missions to invest in more mundane but strategically important institutional needs, such as technology development and workforce training. Augustine said he is concerned that NASA could lose in-house expertise if it relies too heavily on the private industry for newly emerging technologies. "It will have trouble hiring innovative, creative engineers. Innovative, creative engineers don't want to have a job that consists of overseeing other people's work," he said...

The report is hardly a blistering screed. The tone is parental. It praises the agency — with a budget of about $25 billion — for its triumphs while urging more prudent decision-making and long-term strategizing.

NASA pursues spectacular missions. It has sent swarms of robotic probes across the solar system and even into interstellar space. Astronauts have continuously been in orbit for more than two decades. The most ambitious program, Artemis, aims to put astronauts back on the moon in a few short years. And long-term, NASA hopes to put astronauts on Mars. But a truism in the industry is that space is hard. The new report contends that NASA has a mismatch between its ambitions and its budget, and needs to pay attention to fundamentals such as fixing its aging infrastructure and retaining in-house talent. NASA's overall physical infrastructure is already well beyond its design life, and this fraction continues to grow," the report states.

NASA Administrator Bill Nelson said the report "aligns with our current efforts to ensure we have the infrastructure, workforce, and technology that NASA needs for the decades ahead," according to the article.

Nelson added that the agency "will continue to work diligently to address the committee's recommendations."
NASA

Eminent Officials Say NASA Facilities Some of the 'Worst' They've Ever Seen (arstechnica.com) 118

Ars Technica's Stephen Clark reports: A panel of independent experts reported this week that NASA lacks funding to maintain most of its decades-old facilities, could lose its engineering prowess to the commercial space industry, and has a shortsighted roadmap for technology development. "NASA's problem is it always seems to have $3 billion more program than it has of funds," said Norm Augustine, chair of the National Academies panel chartered to examine the critical facilities, workforce, and technology needed to achieve NASA's long-term strategic goals and objectives. Augustine said a similar statement could sum up two previous high-level reviews of NASA's space programs that he chaired in 1990 and 2009. But the report released Tuesday put NASA's predicament in stark terms.

"In NASA's case, the not-uncommon tendency in a constrained budget environment to prioritize initiating new missions as opposed to maintaining and upgrading existing support assets has produced an infrastructure that would not be viewed as acceptable under most industrial standards," the panel wrote in its report. "In fact, during its inspection tours, the committee saw some of the worst facilities many of its members have ever seen." All of NASA's centers have facilities the agency considers marginal, but Johnson Space Center in Houston has the facilities with the worst average score. Johnson oversees astronaut training and is home to NASA's Mission Control Center for the International Space Station and future Artemis lunar missions. The Jet Propulsion Laboratory in California, which develops and operates many of NASA's robotic interplanetary probes, and Stennis Space Center in Mississippi, used for rocket engine testing, are the only centers without a poor infrastructure score.

These ratings cover things like buildings and utilities, not the specific test rigs or instruments inside them. "You can have a world-class microscope and materials lab, but if the building goes down, that microscope is useless to you," [Erik Weiser, NASA's director of facilities and real estate] told the National Academies panel in a meeting last year. The panel recommended that Congress direct NASA to establish an annually replenished revolving working capital fund to pay for maintenance and infrastructure upgrades. Other government agencies use similar funds for infrastructure support. "This is something that will require federal legislation," said Jill Dahlburg, a member of the National Academies panel and former superintendent of the space science division at the Naval Research Laboratory.

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