Richard Tribou reports via Phys.Org: NASA's goal to reduce the costs of the powerful Space Launch System rocket for its Artemis program by 50% was called "highly unrealistic" and a threat to its deep space exploration plans, according to a report by NASA's Office of the Inspector General released (PDF) on Thursday. The audit says the costs to produce one SLS rocket through its proposed fixed-cost contract will still top $2.5 billion, even though NASA thinks it can shrink that through "workforce reductions, manufacturing and contracting efficiencies, and expanding the SLS's user base."

"Given the enormous costs of the Artemis campaign, failure to achieve substantial savings will significantly hinder the sustainability of NASA's deep space human exploration efforts," the report warns. The audit looked at NASA's plans to shift from its current setup among multiple suppliers for the hardware to a sole-sourced services contract that would include the production, systems integration and launch of at least five SLS flights beginning with Artemis V currently slated for as early as 2029. NASA's claim it could get those costs to $1.25 billion per rocket was taken to task by the audit.

"NASA's aspirational goal to achieve a cost savings of 50% is highly unrealistic. Specifically, our review determined that cost saving initiatives in several SLS production contracts were not significant," the audit reads. It does find that rocket costs could approach $2 billion through the first 10 SLS rockets under the new contract, a reduction of 20%. [...] Through 2025, the audit stated its Artemis missions will have topped $93 billion, which includes billions more than originally announced in 2012 as years of delays and cost increases plagued the leadup to Artemis I. The SLS rocket represents 26% of that cost to the tune of $23.8 billion. The inspector general makes several recommendations to NASA. The most striking of which is that NASA consider using commercial heavy-lift rockets, such as SpaceX's Starship and Super Heavy or Blue Origin's New Glenn, as an alternative to the SLS rocket for future Artemis missions.

"Although the SLS is the only launch vehicle currently available that meets Artemis mission needs, in the next 3 to 5 years other human-rated commercial alternatives that are lighter, cheaper, and reusable may become available," the audit reads. "Therefore, NASA may want to consider whether other commercial options should be a part of its mid- to long-term plans to support its ambitious space exploration goals."

Matthew Sparkes reports via NewScientist: A prominent cryptography expert has told New Scientist that a US spy agency could be weakening a new generation of algorithms designed to protect against hackers equipped with quantum computers. Daniel Bernstein at the University of Illinois Chicago says that the US National Institute of Standards and Technology (NIST) is deliberately obscuring the level of involvement the US National Security Agency (NSA) has in developing new encryption standards for "post-quantum cryptography" (PQC). He also believes that NIST has made errors -- either accidental or deliberate -- in calculations describing the security of the new standards. NIST denies the claims.

Bernstein alleges that NIST's calculations for one of the upcoming PQC standards, Kyber512, are "glaringly wrong," making it appear more secure than it really is. He says that NIST multiplied two numbers together when it would have been more correct to add them, resulting in an artificially high assessment of Kyber512's robustness to attack. "We disagree with his analysis," says Dustin Moody at NIST. "It's a question for which there isn't scientific certainty and intelligent people can have different views. We respect Dan's opinion, but don't agree with what he says." Moody says that Kyber512 meets NIST's "level one" security criteria, which makes it at least as hard to break as a commonly used existing algorithm, AES-128. That said, NIST recommends that, in practice, people should use a stronger version, Kyber768, which Moody says was a suggestion from the algorithm's developers.

NIST is currently in a period of public consultation and hopes to reveal the final standards for PQC algorithms next year so that organizations can begin to adopt them. The Kyber algorithm seems likely to make the cut as it has already progressed through several layers of selection. Given its secretive nature, it is difficult to say for sure whether or not the NSA has influenced the PQC standards, but there have long been suggestions and rumors that the agency deliberately weakens encryption algorithms. In 2013, The New York Times reported that the agency had a budget of $250 million for the task, and intelligence agency documents leaked by Edward Snowden in the same year contained references to the NSA deliberately placing a backdoor in a cryptography algorithm, although that algorithm was later dropped from official standards.

Is the asteroid Psyche really a hunk of mostly metal? Is the object, which is nearly as wide as Massachusetts, the core of a baby planet whose rocky outer layers were knocked off during a cataclysmic collision in the early days of the solar system? Right now, all that astronomers can say is maybe, maybe not. NASA launched a spacecraft on Friday morning, also named Psyche, on a journey to the asteroid belt between Mars and Jupiter to find out. From a report: "We're really going to see a kind of new object, which means that a lot of our ideas are going to be proven wrong," said Lindy Elkins-Tanton, a professor of earth and space exploration at Arizona State University who serves as the mission's principal investigator.

Being proven wrong, she added, "is, I think, the most exciting thing in science." That voyage in search of answers kicked off Friday at 10:19 a.m. Eastern time. Falcon Heavy, the largest of SpaceX's operational rockets, lifted off from Kennedy Space Center in Florida, sending the massive spacecraft on a journey that will last about six years and travel billions of miles. Friday's flight overcame early, unfavorable weather forecasts for a seemingly flawless flight. About eight minutes into the flight, the rocket's upper stage entered a 45-minute coasting period during which it will prepare to deploy the spacecraft on its flight away from Earth. The asteroid named Psyche has long been a curious enigma. Spotted in 1852 by Annibale de Gasparis, an Italian astronomer, it is named for the Greek goddess of the soul, and it was just the 16th asteroid to be discovered. In the early observations, it was, like the other asteroids, a starlike point of light that moved in an orbit around the sun, and not much more.

Ed Cara reports via Gizmodo: Scientists appear to have developed a hand prosthetic that provides much more control and comfort than those available today. In new research this week, they've detailed the case of a Swedish woman who has successfully worn the advanced bionic limb for years with no major issues, while experiencing significantly less pain than before. The woman, identified as Karin, suffered a farming injury that took much of her right arm below the elbow over 20 years ago. Like many amputees, Karin went on to develop phantom limb pain, which required her to take high doses of medication to manage. She also benefited little from conventional prosthetics, finding them too unwieldy to use for daily life. But several years ago, Karin became one of the first patients enrolled in the DeTOP project, an expansive research study funded by the European Union and involving dozens of scientists across Europe that's looking to develop the next generation of bionic limbs.

Karin's prosthesis was created by the Italian company Presilia and is nicknamed Mia Hand. It's outfitted with state-of-art technology, including AI. And to further improve its functionality, her surgeons performed osseointegration during the attachment procedure, a process that directly fuses bone to the implant, ideally creating a stronger mechanical connection. They also implanted electrodes in her arm muscles and nerves, as well as rewired some of her nerves in the remaining part of the arm. The result is a robotic limb that's directly connected to Karin's neuromusculoskeletal system.

Much like a real flesh-and-blood hand, it's controlled by Karin's nervous system and provides sensory feedback. Her new hand can purportedly perform around 80% of the typical daily tasks that a regular limb would be able to do. And it's substantially reduced her phantom limb pain and the need for medication. The team's findings on Mia Hand's initial success are published in the journal Science Robotics. Karin is one of three patients enrolled in the DeTOP project. And while it may take time for the research on these patients to reach completion, the hope is that these prosthetics can eventually become the new standard for upper limb amputees. For Karin, it's already been a tremendous gift.

An anonymous reader quotes a report from the Financial Times: A world-first trial of a gene therapy to cure a form of deafness has begun, potentially heralding a revolution in the treatment of hearing loss. Up to 18 children from the UK, Spain and the US are being recruited to the study, which aims to transform treatment of auditory neuropathy, a condition caused by the disruption of nerve impulses traveling from the inner ear to the brain. Participants will be monitored for five years to gauge whether their hearing improves, with initial results expected to be published next February.

Auditory neuropathy can be due to a variation in a single gene -- known as the OTOF gene -- which produces a protein called otoferlin. This protein typically allows the inner hair cells in the ear to communicate with the hearing nerve. Mutations in the OTOF gene can be identified by genetic testing. However, [Professor Manohar Bance, an ear surgeon at Cambridge University Hospitals NHS Foundation Trust who is leading the trial in the UK] said it was a condition often missed when newborn babies were screened for potential hearing problems. "This is one of the few conditions where everything works except the transmission between the hair cells and the nerve. So everything else looks fine when you test it, but they can't hear anything. So these poor kids' [difficulties] end up being missed," Bance added.

The new gene therapy aims to deliver a working copy of the faulty OTOF gene using a modified, non-pathogenic virus. It will be delivered via an injection into the cochlea under general anaesthetic. Bance estimates that about 20,000 people across the US and five European countries -- the UK, Germany, France, Spain and Italy -- have auditory neuropathy due to OTOF mutations, underlining the potential significance of a successful treatment.[...] "If it works, it's 'one and done'" but the cost to health systems "is something that worries me," he added, noting that gene therapies could be priced in "the million dollar range" per patient. However, he hoped that "economies of scale" as the technology developed further would ultimately allow them to be provided more cheaply.

Scientists have used the gene-editing technology known as CRISPR to create chickens that have some resistance to avian influenza, according to a new study that was published in the journal Nature Communications on Tuesday. From a report: The study suggests that genetic engineering could potentially be one tool for reducing the toll of bird flu, a group of viruses that pose grave dangers to both animals and humans. But the study also highlights the limitations and potential risks of the approach, scientists said. Some breakthrough infections still occurred, especially when gene-edited chickens were exposed to very high doses of the virus, the researchers found. And when the scientists edited just one chicken gene, the virus quickly adapted. The findings suggest that creating flu-resistant chickens will require editing multiple genes and that scientists will need to proceed carefully to avoid driving further evolution of the virus, the study's authors said.

The research is "proof of concept that we can move toward making chickens resistant to the virus," Wendy Barclay, a virologist at Imperial College London and an author of the study, said at a news briefing. "But we're not there yet." Some scientists who were not involved in the research had a different takeaway. "It's an excellent study," said Dr. Carol Cardona, an expert on bird flu and avian health at the University of Minnesota. But to Dr. Cardona, the results illustrate how difficult it will be to engineer a chicken that can stay a step ahead of the flu, a virus known for its ability to evolve swiftly. "There's no such thing as an easy button for influenza," Dr. Cardona said. "It replicates quickly, and it adapts quickly."

The jackpot from a seven-year mission to bring back bits of an asteroid was unveiled on Wednesday. From a report: NASA officials in Houston displayed images of salt-and-pepper chunks of rock and particles of dark space dust that were brought back to Earth from the asteroid, Bennu, and described initial scientific observations about the material. The mission, Osiris-Rex, concluded in September when a capsule full of asteroid was jettisoned through Earth's atmosphere and recovered in the Utah desert. The first pieces of materials that leaked outside the container were analyzed using a variety of laboratory techniques, revealing just the earliest findings.

Scientists found water molecules trapped in clay minerals -- water from asteroids similar to Bennu could have filled Earth's oceans. "The reason that Earth is a habitable world, that we have oceans and lakes and rivers and rain, is because these clay minerals, like minerals, like the ones we're seeing from Bennu, landed on Earth four billion years ago," Dante Lauretta, the mission's principal investigator, said during a NASA event on Wednesday. The materials also contained sulfur, key for many geological transformations in rocks.

"It determines how quickly things melt and it is also critical for biology," said Dr. Lauretta, who displayed microscopic images and 3-D visualizations of the material. The scientists also found magnetite, an iron oxide mineral that can play an important role as a catalyst in organic chemical reactions. "We're looking at the kinds of minerals that may have played a central role in the origin of life on Earth," Dr. Lauretta said. The samples are also chock-full of carbon, the element that is the building block for life.

US Space Force has temporarily banned the use of web-based generative AI tools and so-called large language models that power them, citing data security and other concerns, Bloomberg News reported Wednesday, citing a memo. From the report: The Sept. 29 memorandum, addressed to the Guardian Workforce, the term for Space Force members, pauses the use of any government data on web-based generative AI tools, which can create text, images or other media from simple prompts. The memo says they "are not authorized" for use on government systems unless specifically approved.

Chatbots and tools like OpenAI's ChatGPT have exploded in popularity. They make use of language models that are trained on vast amounts of data to predict and generate new text. Such LLMs have given birth to an entire generation of AI tools that can, for example, search through troves of documents, pull out key details and present them as coherent reports in a variety of linguistic styles. Generative AI "will undoubtedly revolutionize our workforce and enhance Guardian's ability to operate at speed," Lisa Costa, Space Force's chief technology and innovation officer, said in the memo. But Costa also cited concerns over cybersecurity, data handling and procurement requirements, saying that the adoption of AI and LLMs needs to be "responsible."

A physicist from the University of Portsmouth has explored whether a new law of physics could support the theory that we're living in a computer simulation. Phys.Org reports: Dr. Melvin Vopson has previously published research suggesting that information has mass and that all elementary particles -- the smallest known building blocks of the universe -- store information about themselves, similar to the way humans have DNA. In 2022, he discovered a new law of physics that could predict genetic mutations in organisms, including viruses, and help judge their potential consequences. It is based on the second law of thermodynamics, which establishes that entropy -- a measure of disorder in an isolated system -- can only increase or stay the same. Dr. Vopson had expected that the entropy in information systems would also increase over time, but on examining the evolution of these systems he realized it remains constant or decreases. That's when he established the second law of information dynamics, or infodynamics, which could significantly impact genetics research and evolution theory.

A new paper, published in AIP Advances, examines the scientific implications of the new law on a number of other physical systems and environments, including biological, atomic physics, and cosmology. Key findings include:

- Biological systems: The second law of infodynamics challenges the conventional understanding of genetic mutations, suggesting that they follow a pattern governed by information entropy. This discovery has profound implications for fields such as genetic research, evolutionary biology, genetic therapies, pharmacology, virology, and pandemic monitoring.
- Atomic physics: The paper explains the behavior of electrons in multi-electron atoms, providing insights into phenomena like Hund's rule; which states that the term with maximum multiplicity lies lowest in energy. Electrons arrange themselves in a way that minimizes their information entropy, shedding light on atomic physics and stability of chemicals.
- Cosmology: The second law of infodynamics is shown to be a cosmological necessity, with thermodynamic considerations applied to an adiabatically expanding universe supporting its validity. "The paper also provides an explanation for the prevalence of symmetry in the universe," added Dr. Vopson. "Symmetry principles play an important role with respect to the laws of nature, but until now there has been little explanation as to why that could be. My findings demonstrate that high symmetry corresponds to the lowest information entropy state, potentially explaining nature's inclination towards it."

"This approach, where excess information is removed, resembles the process of a computer deleting or compressing waste code to save storage space and optimize power consumption. And as a result supports the idea that we're living in a simulation."

Nature's global survey finds that postdoctoral researchers still feel as though they are academia's drudge labourers, but have more confidence about job prospects in a post-pandemic world. Nature: In 2020, respondents to Nature's first global survey of postdoctoral researchers feared that COVID-19 would jeopardize their work. Eighty per cent said the pandemic had hindered their ability to carry out experiments or collect data, more than half (59%) found it harder to discuss their research with colleagues than before the crisis, and nearly two-thirds (61%) thought that the pandemic was hampering their career prospects.

That outlook has changed, according to Nature's second global postdoc survey, carried out in June and July this year. Now only 8% of the respondents say the economic impacts of COVID-19 are their biggest concern (down from 40% in 2020). Instead, they are back to worrying about the usual things: competition for funding, not finding jobs in their fields of interest or feeling pressure to sacrifice personal time for work. Overall, 55% say they are satisfied in their current postdoc, a slide from 60% in 2020. This varies by geography, age and subject area. Postdocs aged 30 and younger are more likely to be satisfied (64%) than are those aged 31-40 (53%). Biomedical postdocs -- who make up slightly more than half of the respondents -- pull the average down, because only 51% say they are satisfied with their jobs.

AI startup Anthropic, writing in a blog post: Neural networks are trained on data, not programmed to follow rules. With each step of training, millions or billions of parameters are updated to make the model better at tasks, and by the end, the model is capable of a dizzying array of behaviors. We understand the math of the trained network exactly -- each neuron in a neural network performs simple arithmetic -- but we don't understand why those mathematical operations result in the behaviors we see. This makes it hard to diagnose failure modes, hard to know how to fix them, and hard to certify that a model is truly safe. Neuroscientists face a similar problem with understanding the biological basis for human behavior. The neurons firing in a person's brain must somehow implement their thoughts, feelings, and decision-making. Decades of neuroscience research has revealed a lot about how the brain works, and enabled targeted treatments for diseases such as epilepsy, but much remains mysterious. Luckily for those of us trying to understand artificial neural networks, experiments are much, much easier to run. We can simultaneously record the activation of every neuron in the network, intervene by silencing or stimulating them, and test the network's response to any possible input.

Unfortunately, it turns out that the individual neurons do not have consistent relationships to network behavior. For example, a single neuron in a small language model is active in many unrelated contexts, including: academic citations, English dialogue, HTTP requests, and Korean text. In a classic vision model, a single neuron responds to faces of cats and fronts of cars. The activation of one neuron can mean different things in different contexts. In our latest paper, Towards Monosemanticity: Decomposing Language Models With Dictionary Learning , we outline evidence that there are better units of analysis than individual neurons, and we have built machinery that lets us find these units in small transformer models. These units, called features, correspond to patterns (linear combinations) of neuron activations. This provides a path to breaking down complex neural networks into parts we can understand, and builds on previous efforts to interpret high-dimensional systems in neuroscience, machine learning, and statistics. In a transformer language model, we decompose a layer with 512 neurons into more than 4000 features which separately represent things like DNA sequences, legal language, HTTP requests, Hebrew text, nutrition statements, and much, much more. Most of these model properties are invisible when looking at the activations of individual neurons in isolation.

A team of scientists drove hundreds of miles through the steppes of Kazakhstan in search of what may be one of the largest and most diverse fungi ecosystems on Earth.

The Washington Post believes their efforts "could help make the planet more resilient to climate change." When these underground fungi come together, they form sophisticated systems known as "mycorrhizal networks...." Mycorrhizal fungi often form mutually beneficial relationships with plants. They trade essential nutrients such as phosphorus and nitrogen in exchange for carbon, and act as an extended root system, allowing plants to access water they can't reach. These networks may also prove to be invaluable for transporting carbon underground, a study published in June found. About 13 gigatons of carbon fixed by vegetation — equivalent to about one-third of all carbon dioxide emissions from fossil fuels in one year — flows through underground fungi, according to an analysis of nearly 200 data sets.

In the steppe, these plant-fungal benefits may be short-lived, however. While deserts are a natural part of Kazakhstan's ecosystem, more than half of the country's vegetation and drylands is at risk of becoming desert as well. The main drivers are large-scale intensive agriculture and increasingly warm and dry temperatures brought by climate change.... Knowing what species of fungi live here is key to understanding how to protect them, said Bethan Manley, project officer at the Society for the Protection of Underground Networks who was on the expedition. It will help determine "where we might be able to have the most effective measures of not poisoning them with fungicides or not having harmful farming practices," she said.

Black Parrot (Slashdot reader #19,622) pointed out a historic anniversary this week: On October 6, 1923, Edwin Hubble got a photo of Andromeda that showed that it contained a variable star, and therefore was an actual galaxy, ending the Great Debate over whether the universe consisted of anything beyond our own galaxy.

Unless you're more than 100 years old you grew up with a completely different understanding of the universe than anyone who lived before. Even Einstein did not know about it when he proposed the theory of general relativity.

It was later in the decade before Hubble discovered that the universe is expanding.
A century later, the European Space Agency was announcing... A very rare, strange burst of extraordinarily bright light in the universe just got even stranger â" thanks to the eagle-eye of the NASA/ESA Hubble Space Telescope. The phenomenon, called a Luminous Fast Blue Optical Transient (LFBOT), flashed onto the scene where it wasnâ(TM)t expected to be found, far away from any host galaxy. Only Hubble could pinpoint its location. The Hubble results suggest astronomers know even less about these objects than previously thought by ruling out some possible theories.
Bill Kendrick (Slashdot reader #19,287) writes: Edwin Hubble's discovery — thanks to a Cepheid Variable star — that the "Andromeda Nebula" was actually an entire galaxy 2.5 million light years away... NASA's Astronomy Photo of the Day for today celebrates this with an image of the original photo plate from October 6, 1923. Notice the "N" (for nova) crossed off, and "VAR!" (for variable) next to the star!

The discovery of Cepheids, and the important fact that their brightening and dimming was regular, and could be used to determine a star's intrinsic brightness, was thanks to Henrietta Swan Leavitt about a decade earlier.

David Butler's "How Far Away Is It?" series has an excellent episode on Andromeda on YouTube.

Slashdot reader TranquilVoid writes: To better understand the battles between native and invasive ants, scientists at Australia's national science agency have turned to Microsoft's classic computer game to model ant warfare.

Across Australia, 50 different species of invasive ants have established themselves, including electric ants, fire ants and yellow crazy ants, with hundreds of millions of dollars spent attempting to eradicate them.

"Ants are one of the few groups of animal species in which warfare resembles human warfare, in terms of scale and mortality," researcher Samuel Lymbery said. The research found small armies of strong soldiers did better in complex terrain-based battlefields and large armies of weaker soldiers fared better in simple open battlefields. In the ant world, a simple battlefield would be a footpath or park while a complex battlefield would be bushland with undergrowth and woody debris.

Dr Lymbery said his work could help develop new approaches to habitat management, like adding undergrowth or more environmental complexity back into urbanised environments, to tip the competitive balance back in favour of native ants.

An announcement from MIT News: One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. However, one major obstacle to this approach is that once the cells are implanted, they eventually run out of oxygen and stop producing insulin.

To overcome that hurdle, MIT engineers have designed a new implantable device that not only carries hundreds of thousands of insulin-producing islet cells, but also has its own on-board oxygen factory, which generates oxygen by splitting water vapor found in the body. The researchers showed that when implanted into diabetic mice, this device could keep the mice's blood glucose levels stable for at least a month. The researchers now hope to create a larger version of the device, about the size of a stick of chewing gum, that could eventually be tested in people with Type 1 diabetes.

"You can think of this as a living medical device that is made from human cells that secrete insulin, along with an electronic life support-system," says Daniel Anderson, a professor in MIT's Department of Chemical Engineering, a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science, and the senior author of the study.

While the researchers' main focus is on diabetes treatment, they say that this kind of device could also be adapted to treat other diseases that require repeated delivery of therapeutic proteins.
Thanks to Slashdot reader schwit1 for sharing the news.