Doctors have begun trialling the world's first mRNA lung cancer vaccine in patients, as experts hailed its "groundbreaking" potential to save thousands of lives. From a report: Lung cancer is the world's leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor. Now experts are testing a new jab that instructs the body to hunt down and kill cancer cells -- then prevents them ever coming back. Known as BNT116 and made by BioNTech, the vaccine is designed to treat non-small cell lung cancer (NSCLC), the most common form of the disease.

The phase 1 clinical trial, the first human study of BNT116, has launched across 34 research sites in seven countries: the UK, US, Germany, Hungary, Poland, Spain and Turkey. The UK has six sites, located in England and Wales, with the first UK patient to receive the vaccine having their initial dose on Tuesday. Overall, about 130 patients -- from early-stage before surgery or radiotherapy, to late-stage disease or recurrent cancer -- will be enrolled to have the jab alongside immunotherapy. About 20 will be from the UK. The jab uses messenger RNA (mRNA), similar to Covid-19 vaccines, and works by presenting the immune system with tumour markers from NSCLC to prime the body to fight cancer cells expressing these markers. The aim is to strengthen a person's immune response to cancer while leaving healthy cells untouched, unlike chemotherapy.

The Wow! signal, detected on August 15, 1977, was an intense radio transmission that appeared artificial and raised the possibility of extraterrestrial contact. However, recent research suggests it may have been caused by a natural astrophysical event involving a magnetar flare striking a hydrogen cloud. Universe Today reports: New research shows that the Wow! Signal has an entirely natural explanation. The research is "Arecibo Wow! I: An Astrophysical Explanation for the Wow! Signal." The lead author is Abel Mendez from the Planetary Habitability Laboratory at the University of Puerto Rico at Arecibo. It's available at the pre-print server arxiv.org. Arecibo Wow! is a new effort based on an archival study of data from the now-defunct Arecibo Radio Telescope from 2017 to 2020. The observations from Arecibo are similar to those from Big Ear but "are more sensitive, have better temporal resolution, and include polarization measurements," according to the authors. "Our latest observations, made between February and May 2020, have revealed similar narrowband signals near the hydrogen line, though less intense than the original Wow! Signal," said Mendez.

Arecibo detected signals similar to the Wow! signal but with some differences. They're far less intense and come from multiple locations. The authors say these signals are easily explained by an astrophysical phenomenon and that the original Wow! signal is, too. "We hypothesize that the Wow! Signal was caused by sudden brightening from stimulated emission of the hydrogen line due to a strong transient radiation source, such as a magnetar flare or a soft gamma repeater (SGR)," the researchers write. Those events are rare and rely on precise conditions and alignments. They can cause clouds of hydrogen to brighten considerably for seconds or even minutes.

The researchers say that what Big Ear saw in 1977 was the transient brightening of one of several H1 (neutral hydrogen) clouds in the telescope's line of sight. The 1977 signal was similar to what Arecibo saw in many respects. "The only difference between the signals observed in Arecibo and the Wow! Signal is their brightness. It is precisely the similarity between these spectra that suggests a mechanism for the origin of the mysterious signal," the authors write. These signals are rare because the spatial alignment between source, cloud, and observer is rare. The rarity of alignment explains why detections are so rare. The researchers were able to identify the clouds responsible for the signal but not the source. Their results suggest that the source is much more distant than the clouds that produce the hydrogen signal. "Given the detectability of the clouds as demonstrated in our data, this insight could enable precise location of the signal's origin and permit continuous monitoring for subsequent events," the researchers explain.

An anonymous reader quotes a report from the Associated Press: A U.S. government report expected to stir debate concluded that fluoride in drinking water at twice the recommended limit is linked with lower IQ in children. The report, based on an analysis of previously published research, marks the first time a federal agency has determined -- "with moderate confidence" -- that there is a link between higher levels of fluoride exposure and lower IQ in kids. While the report was not designed to evaluate the health effects of fluoride in drinking water alone, it is a striking acknowledgment of a potential neurological risk from high levels of fluoride. Fluoride strengthens teeth and reduces cavities by replacing minerals lost during normal wear and tear, according to the U.S. Centers for Disease Control and Prevention. The addition of low levels of fluoride to drinking water has long been considered one of the greatest public health achievements of the last century.

The long-awaited report released Wednesday comes from the National Toxicology Program, part of the Department of Health and Human Services. It summarizes a review of studies, conducted in Canada, China, India, Iran, Pakistan, and Mexico, that concludes that drinking water containing more than 1.5 milligrams of fluoride per liter is consistently associated with lower IQs in kids. The report did not try to quantify exactly how many IQ points might be lost at different levels of fluoride exposure. But some of the studies reviewed in the report suggested IQ was 2 to 5 points lower in children who'd had higher exposures.

Since 2015, federal health officials have recommended a fluoridation level of 0.7 milligrams per liter of water, and for five decades before the recommended upper range was 1.2. The World Health Organization has set a safe limit for fluoride in drinking water of 1.5. The report said that about 0.6% of the U.S. population -- about 1.9 million people -- are on water systems with naturally occurring fluoride levels of 1.5 milligrams or higher. The 324-page report did not reach a conclusion about the risks of lower levels of fluoride, saying more study is needed. It also did not answer what high levels of fluoride might do to adults.

An anonymous reader quotes a report from Ars Technica: Pong will always hold a special place in the history of gaming as one of the earliest arcade video games. Introduced in 1972, it was a table tennis game featuring very simple graphics and gameplay. In fact, it's simple enough that even non-living materials known as hydrogels can "learn" to play the game by "remembering" previous patterns of electrical stimulation, according to a new paper published in the journal Cell Reports Physical Science. "Our research shows that even very simple materials can exhibit complex, adaptive behaviors typically associated with living systems or sophisticated AI," said co-author Yoshikatsu Hayashi, a biomedical engineer at the University of Reading in the UK. "This opens up exciting possibilities for developing new types of 'smart' materials that can learn and adapt to their environment." [...]

The experimental setup was fairly simple. The researchers hooked up electroactive hydrogels to a simulated virtual environment of a Pong game using a custom-built electrode array. The games would start with the ball traveling in a random direction. The hydrogels tracked the ball's position via electrical stimulation and tracked the paddle's position by measuring the distribution of ions in the hydrogels. As the games progressed, the researchers measured how often the hydrogel managed to hit the ball with the paddle. They found that, over time, the hydrogels' accuracy improved, hitting the ball more frequently for longer rallies. They reached their maximum potential for accuracy in about 20 minutes, compared to 10 minutes for the DishBrain. The authors attribute this to the ion movement essentially mapping out a "memory" of all motion over time, exhibiting what appears to be emergent memory functions within the material itself. Perhaps the next step will be to "teach" the hydrogels how to align the paddles in such a way that the rallies go on indefinitely.

In a blog post on Wednesday, Neuralink said its second human recipient is using the brain chip to play Counter-Strike 2 and develop 3D designs in CAD software. "Alex" was given the brain chip last month to help restore his autonomy after a spinal cord injury. PCMag reports: Like the first Neuralink patient, Noland Arbaugh, Alex has also been using the brain chip to play his favorite computer games, such as Counter-Strike 2. Before, Alex had to use a mouth-operated controller, called a QuadStick, to play the first-person shooter. But even then, the controller limited him to only moving or aiming his weapon at a single time, never simultaneously like a normal Counter-Strike player. In other words, Alex had to essentially switch back and forth between the mouse and keyboard functions while playing the game. But thanks to Neuralink, he can now aim with the implant, and simultaneously move while using the QuadStick. [...]

In the blog post, Neuralink also addressed a problem the company faced when placing the chip in Arbaugh, the first patient. Despite a successful surgery, about 85% of the thread-based electrodes attached to his brain later became displaced, undermining the full potential of the chip to read neural signals. Although Arbaugh can still use his implant effectively, Neuralink wanted to avoid a repeat with Alex. In response, the company developed several "mitigations," which include reducing the chance of an air pocket forming during surgery and placing the implant deeper into the brain tissue. "Promisingly, we have observed no thread retraction in our second participant," the company said of Alex.

Whether Alex's implant outperforms the brain chip in Arbaugh was left unclear. In the meantime, Neuralink says it's working on ways to enhance the controls on the technology "to deliver full mouse and video game controller functionality." "Additionally, we plan to enable the Link [brain chip] to interact with the physical world, allowing users to feed themselves and move more independently by controlling a robotic arm or their wheelchair," the company said. You can watch Alex playing Counter-Strike 2 on YouTube.

A growing body of scientific evidence shows that microplastics are accumulating in critical human organs, including the brain, leading researchers to call for more urgent actions to rein in plastic pollution. From a report: Studies have detected tiny shards and specks of plastics in human lungs, placentas, reproductive organs, livers, kidneys, knee and elbow joints, blood vessels and bone marrow. Given the research findings, "it is now imperative to declare a global emergency" to deal with plastic pollution, said Sedat Gundogdu, who studies microplastics at Cukurova University in Turkey. Humans are exposed to microplastics -- defined as fragments smaller than 5mm in diameter -- and the chemicals used to make plastics from widespread plastic pollution in air, water and even food.

The health hazards of microplastics within the human body are not yet well-known. Recent studies are just beginning to suggest they could increase the risk of various conditions such as oxidative stress, which can lead to cell damage and inflammation, as well as cardiovascular disease. Animal studies have also linked microplastics to fertility issues, various cancers, a disrupted endocrine and immune system, and impaired learning and memory.

NASA astronauts Butch Wilmore and Suni Williams are facing challenges returning to Earth due to compatibility issues between their Boeing-designed spacesuits and SpaceX's Dragon spacecraft. Inc. Magazine reports: The space suits in question are the "intra-vehicular activity" outfits now worn by astronauts. They're simpler than the bulky extra-vehicular space suits used on space walks, and are designed to keep astronauts safe in the capsule in the very unlikely case there's a problem that causes the capsule's atmosphere to be lost. The problem is simple: Should Butch and Suni need to fly back aboard SpaceX's vehicle, their suits won't fit in Dragon's seats. [...]

Boeing and SpaceX suits evolved under totally different design sensibilities. If Boeing and NASA deem Starliner unsafe for humans to fly home in, Butch and Suni must head earthward aboard a SpaceX Dragon, but their suits won't be able to plug into Dragon's systems. Like trying to plug an essentially outdated USB A socket into an iPhone's charge port, the suit connectors have different shapes, styles, and functions. The suits themselves have different systems that integrate with their own capsules for purposes like air leak checks during pre-flight testing.

So if an emergency situation presents itself and astronauts have to come back to Earth before proper plans are finalized, Butch and Suni will have to return inside the cargo section of a Dragon space capsule "unsuited," according to NASA leadership who spoke on the matter in a press conference last week. Other plans include flying up suitable Dragon-connecting space suits for the two astronauts on a later mission, should Starliner be deemed incapable of bringing them back.

"A new front has opened in the longstanding debate over how fast the universe is expanding," writes Science magazine: For years astronomers have argued over a gulf between the expansion rate as measured from galaxies in the local universe and as calculated from studies of the cosmic microwave background (CMB), the afterglow of the Big Bang. The disparity was so large and persistent that some astronomers thought the standard theory of the universe might have to be tweaked. But over the past week, results from NASA's new James Webb Space Telescope orbiting observatory suggest the problem may be more mundane: some systematic error in the strategies used to measure the distance to nearby galaxies.

"The evidence based on these data does not suggest the need for additional physics," says Wendy Freedman of the University of Chicago, who leads [the Carnegie-Chicago Hubble Program, or CCHP] that calculated the expansion rate from JWST data using three different galactic distance measurements and released the results on the arXiv preprint server. (The papers have not yet been peer reviewed.) The methods disagreed about the expansion rate, known as the Hubble constant, or H0, and two were close to the CMB prediction.
Specifically, the team used JWST to measure the distance to 10 local galaxies using three stars with a predictable brightness: Cepheids, the brightest red giant stars, and carbon stars. Science notes that the last two methods "agreed to about 1%, but differed from the Cepheid-based distance by 2.5% to 4%." Combining all three methods the team derived a value "just shy of 70 km/s per Mpc," according to the article — leading the University of Chicago's Freedman to say "There's something systematic in the measurements. Until we can establish unambiguously where the issue lies in the nearby universe, we can't be claiming that there's additional physics in the distant universe."

But the controversy continues, according to Adam Riess of Johns Hopkins University (leader of a team of Hubble Constant researchers known as SH0ES). Riess points out that other teams have used JWST to measure distances with all three methods separately and have come up with values closer to the original SH0ES result. He also questions why CCHP excluded data from telescopes other than JWST. "I don't see a compelling justification for excluding the data they do," he says.
Thanks to long-time Slashdot reader sciencehabit for sharing the article.

Citizen scientists from NASA's Backyard Worlds: Planet 9 project discovered a hypervelocity object, CWISE J1249, moving fast enough to escape the Milky Way. "This hypervelocity object is the first such object found with the mass similar to or less than that of a small star," reports NASA's Science Editorial Team, suggesting the object may have originated from a binary star system or a globular cluster. From the report: A few years ago, longtime Backyard Worlds citizen scientists Martin Kabatnik, Thomas P. Bickle, and Dan Caselden spotted a faint, fast-moving object called CWISE J124909.08+362116.0, marching across their screens in the WISE images. Follow-up observations with several ground-based telescopes helped scientists confirm the discovery and characterize the object. These citizen scientists are now co-authors on the team's study about this discovery published in the Astrophysical Journal Letters (a pre-print version is available here). CWISE J1249 is zooming out of the Milky Way at about 1 million miles per hour. But it also stands out for its low mass, which makes it difficult to classify as a celestial object. It could be a low-mass star, or if it doesn't steadily fuse hydrogen in its core, it would be considered a brown dwarf, putting it somewhere between a gas giant planet and a star.

Ordinary brown dwarfs are not that rare. Backyard Worlds: Planet 9 volunteers have discovered more than 4,000 of them! But none of the others are known to be on their way out of the galaxy. This new object has yet another unique property. Data obtained with the W. M. Keck Observatory in Maunakea, Hawaii, show that it has much less iron and other metals than other stars and brown dwarfs. This unusual composition suggests that CWISE J1249 is quite old, likely from one of the first generations of stars in our galaxy. Why does this object move at such high speed? One hypothesis is that CWISE J1249 originally came from a binary system with a white dwarf, which exploded as a supernova when it pulled off too much material from its companion. Another possibility is that it came from a tightly bound cluster of stars called a globular cluster, and a chance meeting with a pair of black holes sent it soaring away.

America's top colleges and finance-industry recruiters have long had their eye on teenage whiz-kids who compete in a prestigious high-school math contest. Now, allegations of cheating are threatening to disrupt it. WSJ: Online leaks of tests for the country's best-known math contest -- the 74-year-old American Mathematics Competition -- are upsetting students who have spent years preparing for the exams. Ahead of the coming school year and test season, angry parents and math coaches have pushed the contest's administrator to tighten controls. The incident is the latest byproduct of a high-pressure college-admissions race that can lead students to look for any edge to get ahead.

[...] As early as elementary school, students interested in flexing their math knowledge beyond what is taught in school can participate in math clubs and competitions. Each year, more than 300,000 students through high school participate in the AMC's first round of multiple-choice tests. Several thousand top performers are invited to sit for a higher-level test, and from there, around 600 compete in national "math olympiads." The top six math students in the nation then represent the U.S. internationally; the U.S. won its ninth International Mathematical Olympiad title this summer.

Murmurs about cheating in the AMC have circulated for a few years, participants say, but reached critical levels during the past school year. The entirety of exams at each level of the competition were available online hours or days before students sat for the tests, a spokeswoman for the Mathematical Association of America confirmed. Testing sites in the U.S. and abroad receive the questions online early to give proctors time to print them out for the in-person exams.

NASA chief Bill Nelson didn't mince words about the agency's budget crunch. "You can't put 10 pounds of potatoes in a five-pound sack," he told ArsTechnica in an interview, addressing $4.7 billion in cuts over two years.

To scientists fretting over axed missions, Nelson offered a frank "I feel your pain." The Mars Sample Return's ballooning $11 billion price tag and 2040 timeline forced a reset. "We pulled the plug," Nelson admitted, but he's banking on cheaper, creative alternatives emerging by year's end.

The moon rover Viper got the chop too, blowing its budget by 40%. "There comes a limit," Nelson said, defending the tough call. Viper lunar rover project was "running 40 percent over budget." He defended these decisions as necessary given the $2 billion cut to science funding alone. The cuts stem from the Fiscal Responsibility Act. Nelson expressed hope for a "reprieve" in fiscal year 2026, but noted uncertainty due to another looming debt ceiling issue.

AT&T and Verizon are urging the FCC to reject SpaceX's plan to offer cellular service with T-Mobile, arguing that it would cause harmful interference to terrestrial mobile networks. Ars Technica reports: Filings urging the Federal Communications Commission to deny SpaceX's request for a waiver were submitted by AT&T and Verizon this week. The plan by SpaceX's Starlink division also faces opposition from satellite companies EchoStar (which owns Dish and Hughes) and Omnispace. SpaceX and T-Mobile plan to offer Supplemental Coverage from Space (SCS) for T-Mobile's cellular network using SpaceX satellites. As part of that plan, SpaceX is seeking a waiver of FCC rules regarding out-of-band emission limits.

AT&T's petition to deny the SpaceX waiver request said the FCC's "recent SCS order appropriately recognized that SCS deployments should not present any risk to the vital terrestrial mobile broadband networks upon which millions of Americans rely today. The Commission authorized SCS as secondary to terrestrial mobile service, correctly explaining that the SCS framework must 'retain service quality of terrestrial networks, protect spectrum usage rights, and minimize the risk of harmful interference.'" AT&T said SpaceX's requested "ninefold increase" to the allowable power flux-density limits for out-of-band emissions "would cause unacceptable harmful interference to incumbent terrestrial mobile operations. Specifically, AT&T's technical analysis shows that SpaceX's proposal would cause an 18% average reduction in network downlink throughput in an operational and representative AT&T PCS C Block market deployment." Verizon's opposition to the waiver request similarly said that SpaceX's proposal "would subject incumbent, primary terrestrial licensee operations in adjacent bands to harmful interference." Wireless phone performance will suffer, Verizon said [...]. SpaceX and T-Mobile told FCC staff that their plan will not harm other wireless operations and predicted that competitors will make misleading claims. SpaceX also argued that the FCC's emissions limit is too strict and should be changed.

An anonymous reader quotes a report from the New York Times: Melted capsules. Cloudy insulin. Pills that may no longer work. Doctors and pharmacists say the scorching temperatures enveloping the country could be endangering people's health in an unexpected way: by overheating their medications. Millions of Americans now receive their prescription medications through mail-order shipments, either for convenience or because their health plans require it. But the temperatures inside the cargo areas of delivery trucks can reach 150 degrees Fahrenheit in the summer, according to drivers -- far exceeding the range of 68 to 77 degrees recommended by the national organization that sets standards for drug handling.

Mail-order pharmacies say that their packaging is weather resistant and that they take special precautions when medication "requires specific temperature control." But in a study published last year, independent pharmaceutical researchers who embedded data-logging thermometers inside simulated shipments found that the packages had spent more than two-thirds of their transit time outside the appropriate temperature range, "regardless of the shipping method, carrier, or season." Extreme temperatures can alter the components in many medications, from pancreatic enzymes to the thyroid replacement drug levothyroxine to oral contraceptives, medical experts say.

Dr. Mike Ren, a primary care physician and an assistant professor in the department of family and community medicine at the Baylor College of Medicine, said that liquid medications like insulin or AUVI-Q, the epinephrine injection for allergic reactions, are often at heightened risk of degradation because excessive heat exposure can cause the evaporation of liquid components that were compounded at precise ratios. Aerosolized medications, too, are uniquely vulnerable because of the risk of pressure changes in the canister. "Doctors recommend picking up your prescriptions at a local pharmacy whenever possible during hot summer months, particularly if your medication is liquid or aerosolized," notes the report. "If you are enrolled in an insurance program that requires using a mail-order pharmacy, ask for an exception during the summer or, at the very least, contact the on-call pharmacist at the mail-order company to get more information about shipping practices and to ask for temperature-controlled packaging. You should do this even if the drug does not require refrigeration."

Once you do get your medication, you should make sure to preserve it in a cool, dry environment, away from direct sunlight. If you're flying, your prescriptions should be stored in your carry-on bag. They should never be left in a parked car.

sciencehabit shares a report from Science Magazine: A species of lungfish found in South America has claimed the title of the animal with the biggest genome sequenced so far. The DNA of Lepidosiren paradoxa comprises a staggering 91 billion chemical letters or "bases," 30 times as many as the human genome, researchers report today in Nature. However, those 91 billion bases of DNA only contain about the same number of genes that humans have -- roughly 20,000 -- with the rest consisting of noncoding, perhaps even "junk" DNA. By comparing this genome with those of other lungfishes, the researchers determined that L. paradoxa adds the equivalent of a human genome to its DNA every 10 million years.

Ars Technica's John Timmer reports: [T]he International Astronomical Union has a resolution that calls for a "Lunar Celestial Reference System" and "Lunar Coordinate Time" to handle things there. On Monday, two researchers at the National institute of Standards and Technology, Neil Ashby and Bijunath Patla, did the math to show how this might work. [...] Ashby and Patla worked on developing a system where anything can be calculated in reference to the center of mass of the Earth/Moon system. Or, as they put it in the paper, their mathematical system "enables us to compare clock rates on the Moon and cislunar Lagrange points with respect to clocks on Earth by using a metric appropriate for a locally freely falling frame such as the center of mass of the Earth-Moon system in the Sun's gravitational field." What does this look like? Well, a lot of deriving equations. The paper's body has 55 of them, and there are another 67 in the appendices. So, a lot of the paper ends up looking like this.

Things get complicated because there are so many factors to consider. There are tidal effects from the Sun and other planets. Anything on the surface of the Earth or Moon is moving due to rotation; other objects are moving while in orbit. The gravitational influence on time will depend on where an object is located. So, there's a lot to keep track of. Ashby and Patla don't have to take everything into account in all circumstances. Some of these factors are so small they'll only be detectable with an extremely high-precision clock. Others tend to cancel each other out. Still, using their system, they're able to calculate that an object near the surface of the Moon will pick up an extra 56 microseconds every day, which is a problem in situations where we may be relying on measuring time with nanosecond precision. And the researchers say that their approach, while focused on the Earth/Moon system, is still generalizable. Which means that it should be possible to modify it and create a frame of reference that would work on both Earth and anywhere else in the Solar System. Which, given the pace at which we've sent things beyond low-Earth orbit, is probably a healthy amount of future-proofing. The findings have been published in the Astronomical Journal. A National Institute of Standards and Technology (NIST) press release announcing the work can be found here.