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Medicine

Woman's Mystery Illness Turns Out To Be 3-Inch Snake Parasite In Her Brain 103

An anonymous reader quotes a report from Ars Technica: A neurosurgeon in Australia pulled a wriggling 3-inch roundworm from the brain of a 64-year-old woman last year -- which was quite the surprise to the woman's team of doctors and infectious disease experts, who had spent over a year trying to identify the cause of her recurring and varied symptoms. A close study of the extracted worm made clear why the diagnosis was so hard to pin down: the roundworm was one known to infect snakes -- specifically carpet pythons endemic to the area where the woman lived -- as well as the pythons' mammalian prey. The woman is thought to be the first reported human to ever have an infection with this snake-adapted worm, and it is the first time the worm has been found burrowing through a mammalian brain. [...]

Subsequent examination determined the roundworm was Ophidascaris robertsi based on its red color and morphological features. Genetic testing confirmed the identification. The woman went on ivermectin again and another anti-parasitic drug, albendazole. Months later, her lung and liver lesions improved, and her neuropsychiatric symptoms persisted but were improved. The doctors believe the woman became infected after foraging for warrigal greens (aka New Zealand spinach) around a lake near her home that was inhabited by carpet pythons. Usually, O. robertsi adults inhabit the snakes' esophagus and stomach and release their eggs in the snakes' feces. From there, the eggs are picked up by small mammals that the snakes feed upon. The larvae develop and establish in the small mammals, growing quite long despite the small size of the animals, and the worm's life cycle is complete when the snake eats the infected prey.

Doctors hypothesize the woman picked up the eggs meant for small mammals as she foraged, ingesting them either by not fully washing or cooking the greens or by not properly washing her hands or kitchen equipment. In retrospect, the progression of her symptoms suggests an initial foodborne infection, followed by worm larva migrating from her gastrointestinal tract to multiple organs. The prednisolone, an immunosuppressive drug, may have inadvertently helped the worm migrate and get into the central nervous system. Kennedy, a co-author of the report on the woman's case, stressed the importance of washing any foods foraged or taken from a garden. She also emphasized proper kitchen safety and hand washing.
Earth

Polluted Air Shortens Human Lifespans More Than Tobacco, Study Finds (wsj.com) 104

Cigarette smoking and other uses of tobacco shave an average of 2.2 years off lifespans globally. But merely breathing -- if the air is polluted -- is more damaging to human health. From a report: That is the conclusion of a report published Tuesday by the University of Chicago's Energy Policy Institute, which identified air pollution as the world's top threat to public health, responsible for reducing average life expectancy by 2.3 years worldwide. China, once the poster child for smog-filled skies, has been a surprise success story. Between 2013 and 2021, the world's second-largest economy improved overall air quality by more than 40% while the average lifespan of residents increased by more than two years, according to the report.

By contrast, four countries in South Asia -- India, Bangladesh Nepal and Pakistan -- accounted for more than half of the total years of life lost globally due to pollution in the atmosphere over the same eight years. India alone was responsible for nearly 60% of the growth in air pollution across the globe during that time. If India were to meet World Health Organization guidelines for particulate pollution, the life expectancy for residents of capital city New Delhi would increase by 12 years. An increase in wildfires in places such as California and Canada has renewed attention on the dangers of polluted air. Around 350 cities globally suffer the same level of dangerous haze that enveloped New York City in June at least once a year, according to calculations from environmental think tank Centre for Research on Energy and Clean Air, which aggregates data from dozens of official government sources.

Science

Scientists Engineered a See-Through Squid With Its Brain In Plain View (npr.org) 35

Scientists have genetically engineered a hummingbird bobtail squid to remove its pigment, creating an almost completely transparent animal with only its three hearts and brain showing when light hits it at the right angle. According to NPR, "The see-through squid are offering scientists a new way to study the biology of a creature that is intact and moving freely." From the report: The see-through version is made possible by a gene editing technology called CRISPR, which became popular nearly a decade ago. [Scientists Caroline Albertin and Joshua Rosenthal at the Marine Biological Laboratory in Woods Hole, Mass.] thought they might be able to use CRISPR to create a special squid for research. They focused on the hummingbird bobtail squid because it is small, a prodigious breeder, and thrives in lab aquariums, including one at the lab in Woods Hole. Albertin and Rosenthal wanted to use CRISPR to create a bobtail squid without any pigment, an albino. And they knew that in other squid, pigment depends on the presence of a gene called TDO.

"So we tried to knock out TDO," Albertin says, "and nothing happened." It turned out that bobtail squid have a second gene that also affects pigment. "When we targeted that gene, lo and behold we were able to get albinos," Albertin says. Because even unaltered squid have clear blood, thin skin, and no bones, the albinos are all but transparent unless light hits them at just the right angle. Early on, Albertin and Rosenthal realized these animals would be of interest to brain scientists. So they contacted Ivan Soltesz at Stanford and Cristopher Niell at the University of Oregon. "We said, 'Hey, you guys, we have this incredible animal, want to look at its brain," Rosenthal says. "They jumped on it."

Soltesz and Niell inserted a fluorescent dye into an area of the brain that processes visual information. The dye glows when it's near brain cells that are active. Then the scientists projected images onto a screen in front of the squid. And the brain areas involved in vision began to glow, something that would have been impossible to see in a squid with pigment. Because it suggests that her see-through squid will help scientists understand not only cephalopods, but all living creatures.
The findings have been published in the journal Current Biology.
Science

CERN's Large Hadron Collider Makes Its First Observations of Neutrinos (phys.org) 35

Physicists have observed neutrinos originating "from the sun, cosmic rays, supernovae and other cosmic objects, as well as particle accelerators and nuclear reactors," writes Phys.org. But one remaining goal was observing neutrinos inside "collider" particle accelerators (which direct two particle beams).

It's now been accomplished using neutrino detectors located at CERN's Large Hadron Collider (LHC) in Switzerland by two distinct research collaborations:

- FASER (Forward Search Experiment)
- SND (Scattering and Neutrino Detector)@LHC

Phys.org argues the two achievements "could open important new avenues for experimental particle physics research. " The results of their two studies were recently published in Physical Review Letters. "Neutrinos are produced very abundantly in proton colliders such as the LHC," Cristovao Vilela, part of the SND@LHC Collaboration, told Phys.org. "However, up to now, these neutrinos had never been directly observed. The very weak interaction of neutrinos with other particles makes their detection very challenging and because of this they are the least well studied particles in the Standard Model of particle physics...."

"Particle colliders have existed for over 50 years, and have detected every known particle except for neutrinos," Jonathan Lee Feng, co-spokesperson of the FASER Collaboration, told Phys.org. "At the same time, every time neutrinos have been discovered from a new source, whether it is a nuclear reactor, the sun, the Earth, or supernovae, we have learned something extremely important about the universe. As part of our recent work, we set out to detect neutrinos produced at a particle collider for the first time...

"Because these neutrinos have high fluxes and high energies, which makes them far more likely to interact, we were able to detect 153 of them with a very small, inexpensive detector that was built in a very short time," Feng explained. "Previously, particle physics was thought to be divided into two parts: high energy experiments, which were required to study heavy particles, like top quarks and Higgs bosons, and high intensity experiments, which were required to study neutrinos. This work has shown that high energy experiments can also study neutrinos, and so has brought together the high-energy and high-intensity frontiers."

The neutrinos detected by Feng and the rest of the FASER collaboration have the highest energy ever recorded in a laboratory environment.... Cristovao Vilela, part of the SND@LHC Collaboration, said "The observation of collider neutrinos opens the door to novel measurements which will help us understand some of the more fundamental puzzles of the Standard Model of particle physics, such as why there are three generations of matter particles (fermions) that seem to be exact copies of each other in all aspects except for their mass. Furthermore, our detector is placed in a location which is a blind spot for the larger LHC experiments. Because of this, our measurements will also contribute to a better understanding of the structure of colliding protons."

Science

Why Do Cats Love Tuna So Much? Scientists May Finally Know (science.org) 67

Slashdot reader sciencehabit writes: One thing most cats seem to have in common is a deep love of tuna. That's an odd predilection for a creature that evolved in the desert, with nary a fish in sight. Now scientists think they've nailed down the biology behind this curious craving.

In a series of experiments researchers showed for the first time that cats contain the necessary molecular machinery on their taste buds to detect umami--the savory, deep flavor of various meats, and one of the five basic tastes in addition to sweet, sour, salty, and bitter. In taste tests, the cats gravitated towards bowls of water laced with compounds present at high levels in umami foods. Indeed, umami appears to be the primary flavor that attracts cats--no surprise for an obligate carnivore.

But the team found something more remarkable: The felines showed a particular preference for bowls containing histidine and inosine monophosphate — compounds found at particularly high levels in tuna. "It was one of the most preferred combinations," says one of the scientists. "It really seems to hit that umami sweet spot."

The work doesn't just explain why cats have a particular hankering for tuna. It could help manufacturers develop more palatable meals for our finicky friends and even medications that they won't spit across the room.

Exactly why cats evolved a taste for tuna--or any kind of fish--remains a mystery. It may have been a taste they developed over time. As far back as 1500 B.C.E., cats are depicted eating fish in the art of Ancient Egypt. And by the Middle Ages, felines in some Middle Eastern ports were consuming large quantities of fish — including tuna — likely because they were feasting on the scraps left by fishers. In both cases, cats that evolved a taste for fish — and perhaps tuna in particular — may have had an advantage over their comrades who stuck solely to rodents and birds.

ISS

Watch SpaceX Deliver Four Astronauts to the International Space Station (space.com) 41

For SpaceX's 11th crewed mission — its eighth flight for NASA — "A SpaceX Dragon spacecraft carrying four astronauts will arrive at the International Space Station early Sunday," reports Space.com, "and you can watch it all live online in a free livestream." The Crew Dragon capsule Endurance is scheduled to reach the International Space Station at 8:39 a.m. EDT (1239 GMT), where it will dock itself to a space-facing port on the outpost's U.S.-built Harmony module.

The docking will mark the end of a nearly 30-hour journey for the capsule's four-person crew, which launched in the wee hours of Saturday from NASA's Pad 39A at the Kennedy Space Center in Florida... "SpaceX, thanks for the ride, it was awesome," Crew-7 commander Jasmin Moghbeli of NASA said after the crew reached orbit. "Go Crew-7, awesome ride." SpaceX's Crew-7 mission for NASA is ferrying Moghbeli to the ISS with a truly international crew: pilot Andreas Mogensen of the European Space Agency; and mission specialists Konstantin Borisov of Russia's Roscosmos agency and Satoshi Furukawa of the Japan Aerospace Exploration Agency. The quartet is the first all-international crew, with members from four different agencies and countries, to fly on the same Dragon capsule...

The Crew-7 astronauts are beginning a six-month expedition to the space station and will relieve the four astronauts of NASA's Crew-6 mission, who are due to return shortly after Moghbeli and her crew arrive.

SpaceX has created a "follow Dragon" web page with graphics tracking the capsule's progress to the Space Station...
Science

Atoms Aren't Empty (aeon.co) 187

Kitty Oppenheimer: Can you explain quantum mechanics to me?

J. Robert Oppenheimer: Well, this glass, this drink, this counter top, uhh.. our bodies, all of it. It's mostly empty space. Groupings of tiny energy waves bound together.

Kitty Oppenheimer: By what?

J. Robert Oppenheimer: Forces of attraction strong enough to convince us [that] matter is solid, to stop my body passing through yours.


IMDB quote from Oppenheimer


Flash forward to 2023, where Mario Barbatti is a theoretical chemist and physicist researching light and molecule interactions. He's also a professor of chemistry at Aix Marseille University in France. Writing this week for Aeon, Barbatti argues that "there are no empty spaces within the atom.

"The empty atom picture is likely the most repeated mistake in popular science." It is unclear who created this myth, but it is sure that Carl Sagan, in his classic TV series Cosmos (1980), was crucial in popularising it. After wondering how small the nuclei are compared with the atom, Sagan concluded that "[M]ost of the mass of an atom is in its nucleus; the electrons are by comparison just clouds of moving fluff. Atoms are mainly empty space. Matter is composed chiefly of nothing." I still remember how deeply these words spoke to me when I heard them as a kid in the early 1980s. Today, as a professional theoretical chemist, I know that Sagan's statements failed to recognise some fundamental features of atoms and molecules...

Misconceptions feeding the idea of the empty atom can be dismantled by carefully interpreting quantum theory, which describes the physics of molecules, atoms and subatomic particles. According to quantum theory, the building blocks of matter — like electrons, nuclei and the molecules they form — can be portrayed either as waves or particles. Leave them to evolve by themselves without human interference, and they act like delocalised waves in the shape of continuous clouds. On the other hand, when we attempt to observe these systems, they appear to be localised particles, something like bullets in the classical realm. But accepting the quantum predictions that nuclei and electrons fill space as continuous clouds has a daring conceptual price: it implies that these particles do not vibrate, spin or orbit. They inhabit a motionless microcosmos where time only occasionally plays a role...

A molecule is a static object without any internal motion. The quantum clouds of all nuclei and electrons remain absolutely still for a molecule with a well-defined energy. Time is irrelevant... Time, however, comes into play when a molecule collides with another one, triggering a chemical reaction. Then, a storm strikes. The quantum steadiness bursts when the sections of the electronic cloud pour from one molecule upon another. The clouds mix, reshape, merge, and split. The nuclear clouds rearrange to accommodate themselves within the new electronic configuration, sometimes even migrating between molecules. For a fraction of a picosecond (10-12 seconds or a billionth of a millisecond), the tempest rages and reshapes the molecular landscape until stillness is restored in the newly formed compounds.

Mars

Perseverance Mars Rover Spies Big Sunspot Rotating Toward Earth (space.com) 15

Long-time Slashdot reader SonicSpike shares a new perspective on sunspots (those dark, cool areas where the sun's magnetic field is particularly strong, and which often launch solar flares).

"NASA's Perseverance Mars rover has given us a sneak peek of an intriguing patch of the sun that's not yet visible from Earth," reports Space.com: Perseverance photographs the sun daily with its Mastcam-Z camera system to gauge the amount of dust in the Martian atmosphere. Such an effort captured a big sunspot moving across the solar disk late last week and over the weekend, as SpaceWeather.com reported. "Because Mars is orbiting over the far side of the sun, Perseverance can see approaching sunspots more than a week before we do," SpaceWeather.com wrote in a post highlighting the sunspot photos. "Consider this your one-week warning: A big sunspot is coming...."

Solar flares and coronal mass ejections that hit Earth can affect satellite navigation and disrupt power grids, among other things, so tracking the movement of sunspots is more than just of academic interest.

Medicine

Marketers Overstate Fish Oil Claims for Heart Health, Study Shows (msn.com) 65

An anonymous reader shared this report from the Washington Post: Most research shows that over-the-counter fish oil supplements don't offer cardiovascular benefits, but that hasn't stopped marketers from touting them for heart health, a new study shows.

The sale of fish oil supplements is a multibillion-dollar industry, and many people take fish oil capsules daily, believing the omega-3 fatty acids they contain are good for their overall health, particularly for their heart. While it's true people who eat seafood regularly are less likely to die of heart disease, studies have not shown that taking fish oil as a supplement offers the same benefit. Even so, fish oil marketers continue to make health claims that imply a wide range of benefits, according to a study published Wednesday in JAMA Cardiology.

The researchers analyzed labels from more than 2,000 fish oil supplements that made health claims. They found more than 80 percent used what is known as a "structure and function claim," which is a general description that describes the role of omega-3 fatty acids in the body — such as "promotes heart health" or "supports heart, mind and mood." Cardiovascular health claims, which accounted for 62 percent, were most common.

Fish oil contains two omega-3 fatty acids, EPA and DHA, found naturally in fatty fish such as salmon. Higher levels of these omega-3s have been associated with a lower risk of cardiovascular disease, but the observational findings are based on omega-3 levels in the diet, not from supplement use, some experts say. Two recent large clinical trials showed that over-the-counter fish oil supplements do not improve cardiovascular outcomes. But the vagueness of the wording used by fish oil marketers could lead to misinformation about the role of the dietary supplement, said Ann Marie Navar, associate professor of cardiology at the University of Texas Southwestern Medical Center, who was senior author of the study.

Navar says in the article "It is true that omega-3 fatty acids are present in the brain and are important for all sorts of brain functions.

"What has not been consistently shown with high-quality trials is that taking more of it in the form of a fish oil supplement leads to improved performance or prevention of disease."
Science

90% of Paper Straws Contain Toxic Forever Chemicals, Study Finds (newatlas.com) 105

A European study reveals that around 90% of eco-friendly paper straws contain "forever chemicals" called PFAS, which do not easily break down and can accumulate in the body, potentially causing health issues. New Atlas reports: "Forever chemicals" is the colloquial name given to a class of more than 12,000 chemicals, more formally known as poly- and perfluoroalkyl substances (PFAS), that barely break down in the environment or in our bodies. Hence, the "forever" part. [...] The researchers tested 39 different brands of straws made from paper, glass, bamboo, stainless steel, and plastic, and analyzed them for 29 different PFAS compounds. The majority of brands tested (69%) contained PFAS, with 18 different PFAS detected in total. Paper straws were most likely to contain PFAS, with the chemicals detected in 90% of the brands tested, albeit in highly variable concentrations. Perfluorooctanoic acid (PFOA), a compound linked to high cholesterol, a reduced immune response, thyroid disease and increased kidney and testicular cancer, was most frequently detected. PFOA has been banned globally since 2020. Also detected were trifluoroacetic acid (TFA) and trifluoromethanesulfonic acid (TFMS), ultra-short-chain PFAS that are highly water-soluble and so might leach out of straws into drinks.

Bamboo straws fared only slightly better than paper ones, with PFAS found in 80% of brands tested. The chemicals were found in 75% of plastic straws and 40% of glass brands. PFAS were not detected in any of the steel straws tested. The PFAS concentrations were low and, the researchers say, pose a small risk to human health. However, the problem with PFAS is that they're bioaccumulative, meaning they can build up over time because they're absorbed but not excreted. The researchers say that while the study did not determine whether PFAS were added to the straws or were the result of contamination -- for example, from the soil in which the plant-based materials are grown -- the presence of the chemicals in almost every brand of paper straw means it's likely that, in some cases, PFAS were used as a water-repellent coating. The study also did not examine whether PFAS leached out of the straws into the liquid they were sitting in. To be safe, the researchers suggest people start using stainless steel straws, or ditch straws altogether.
The study was published in the journal Food Additives and Contaminants.
Space

SpaceX Test-Fires Booster For Second Starship Launch (spacenews.com) 65

SpaceX says it successfully test-fired the booster for its next Starship launch, although that liftoff may still be weeks away. SpaceNews reports: SpaceX fired the Raptor engines in the Super Heavy booster designated Booster 9 in a static-fire test at its Starbase test site in Boca Chica, Texas, at approximately 1:35 p.m. Eastern Aug. 25. SpaceX said it conducted a "full duration" firing, which appeared to last about five to six seconds. SpaceX later stated that all 33 engines successfully ignited, although two shut down prematurely. "Congratulations to the SpaceX team on this exciting milestone!"

The company did not state if that performance was sufficient for it to proceed with a launch attempt, but it was better than an earlier test of the same booster Aug. 6. That test ended early, after the engines fired for less than three seconds, with four of the Raptors shutting down prematurely. If SpaceX is satisfied with the outcome of the test, it is likely one of the final technical milestones before it is ready for a second integrated Starship/Super Heavy launch. The first, April 20, failed four minutes after liftoff when several Raptor engines in the Super Heavy booster shut down and vehicle later lost control and tumbled.

Biotech

The 'Weird' Male Y Chromosome Has Finally Been Fully Sequenced (theconversation.com) 145

An anonymous reader quotes a report from The Conversation: The Y chromosome is a never-ending source of fascination (particularly to men) because it bears genes that determine maleness and make sperm. It's also small and seriously weird; it carries few genes and is full of junk DNA that makes it horrendous to sequence. However, new "long-read" sequencing techniques have finally provided a reliable sequence from one end of the Y to the other. The paper describing this Herculean effort has been published in Nature. The findings provide a solid base to explore how genes for sex and sperm work, how the Y chromosome evolved, and whether -- as predicted -- it will disappear in a few million years. [...]

Spoiler alert -- the Y turns out to be just as weird as we expected from decades of gene mapping and the previous sequencing. A few new genes have been discovered, but these are extra copies of genes that were already known to exist in multiple copies. The border of the pseudoautosomal region (which is shared with the X) has been pushed a bit further toward the tip of the Y chromosome. We now know the structure of the centromere (a region of the chromosome that pulls copies apart when the cell divides), and have a complete readout of the complex mixture of repetitive sequences in the fluorescent end of the Y.

But perhaps the most important outcome is how useful the findings will be for scientists all over the world. Some groups will now examine the details of Y genes. They will look for sequences that might control how SRY and the sperm genes are expressed, and to see whether genes that have X partners have retained the same functions or evolved new ones. Others will closely examine the repeated sequences to determine where and how they originated, and why they were amplified. Many groups will also analyze the Y chromosomes of men from different corners of the world to detect signs of degeneration, or recent evolution of function. It's a new era for the poor old Y.

Science

Graphene Surprise Could Help Generate Hydrogen Cheaply and Sustainably (scitechdaily.com) 57

echo123 shares a report from SciTechDaily: Researchers have discovered that graphene naturally allows proton transport, especially around its nanoscale wrinkles. This finding could revolutionize the hydrogen economy by offering sustainable alternatives to existing catalysts and membranes. [...] In a recent publication in the journal Nature, a joint effort between the University of Warwick, spearheaded by Prof. Patrick Unwin, and The University of Manchester, led by Dr. Marcelo Lozada-Hidalgo and Prof. Andre Geim, presented their findings on this matter. Using ultra-high spatial resolution measurements, they conclusively demonstrated that perfect graphene crystals indeed allow proton transport. In a surprising twist, they also found that protons are strongly accelerated around nanoscale wrinkles and ripples present in the graphene crystal.

This groundbreaking revelation carries immense significance for the hydrogen economy. The current mechanisms for generating and using hydrogen often rely on costly catalysts and membranes, some of which have notable environmental impacts. Replacing these with sustainable 2D crystals like graphene could play a pivotal role in advancing green hydrogen production, subsequently reducing carbon emissions and aiding the shift towards a Net Zero carbon environment. [...] The team is optimistic about how this discovery can pave the way for novel hydrogen technologies. Dr. Lozada-Hidalgo said, "Exploiting the catalytic activity of ripples and wrinkles in 2D crystals is a fundamentally new way to accelerate ion transport and chemical reactions. This could lead to the development of low-cost catalysts for hydrogen-related technologies."

Science

Scientific Journal Retracts Article That Claimed No Evidence of Climate Crisis (theguardian.com) 100

One of the world's biggest scientific publishers has retracted a journal article that claimed to have found no evidence of a climate crisis. From a report: Springer Nature said it had retracted the article, by four Italian physicists, after an internal investigation found the conclusions were "not supported by available evidence or data provided by the authors." Climate sceptic groups widely publicised the article, which appeared in the European Physical Journal Plus in January 2022 -- a journal not known for publishing climate change science.

Nine months later the article was reported uncritically in a page one story in the Australian newspaper and promoted in two segments on Sky News Australia -- a channel that has been described as a global hub for climate science misinformation. The segments were viewed more than 500,000 times on YouTube. The article claimed to have analysed data to find no trend in rainfall extremes, floods, droughts and food productivity. "In conclusion on the basis of observational data, the climate crisis that, according to many sources, we are experiencing today, is not evident yet," the article said.

Several climate scientists told the Guardian and later the news agency AFP that the article had misrepresented some scientific articles, was "selective and biased" and had "cherrypicked" information. After those concerns were raised, Springer Nature announced in October it was investigating the article. In a statement Springer Nature said its editors had launched a "thorough investigation," which included a post-publication review by subject matter experts. The authors of the article also submitted an addendum to their original work during the course of the investigation, the statement said.

Java

Scientists Strengthen Concrete By 30 Percent With Used Coffee Grounds (engadget.com) 84

According to a team of researchers from RMIT University in Australia, coffee grounds can be used as a silica substitute in the concrete production process to yield a significantly stronger chemical bond than sand alone. Engadget reports: "The disposal of organic waste poses an environmental challenge as it emits large amounts of greenhouse gases including methane and carbon dioxide, which contribute to climate change," lead author of the study, Dr Rajeev Roychand of RMIT's School of Engineering, said in a recent release. He notes that Australia alone produces 75 million kilograms of used coffee grounds each year, most of which ends up in landfills. Coffee grounds can't simply be mixed in raw with standard concrete as they won't bind with the other materials due to their organic content, Dr. Roychand explained. In order to make the grounds more compatible, the team experimented with pyrolyzing the materials at 350 and 500 degrees C, then substituting them in for sand in 5, 10, 15 and 20 percentages (by volume) for standard concrete mixtures.

The team found that at 350 degrees is perfect temperature, producing a "29.3 percent enhancement in the compressive strength of the composite concrete blended with coffee biochar," per the team's study, published in the September issue of Journal of Cleaner Production. "In addition to reducing emissions and making a stronger concrete, we're reducing the impact of continuous mining of natural resources like sand," Dr. Roychand said.

Medicine

Paralyzed Woman Able To 'Speak' Through Digital Avatar In World First 14

An anonymous reader quotes a report from The Guardian: A severely paralyzed woman has been able to speak through an avatar using technology that translated her brain signals into speech and facial expressions. The latest technology uses tiny electrodes implanted on the surface of the brain to detect electrical activity in the part of the brain that controls speech and face movements. These signals are translated directly into a digital avatar's speech and facial expressions including smiling, frowning or surprise. The patient, a 47-year-old woman, Ann, has been severely paralyzed since suffering a brainstem stroke more than 18 years ago. She cannot speak or type and normally communicates using movement-tracking technology that allows her to slowly select letters at up to 14 words a minute. She hopes the avatar technology could enable her to work as a counsellor in future.

The team implanted a paper-thin rectangle of 253 electrodes on to the surface of Ann's brain over a region critical for speech. The electrodes intercepted the brain signals that, if not for the stroke, would have controlled muscles in her tongue, jaw, larynx and face. After implantation, Ann worked with the team to train the system's AI algorithm to detect her unique brain signals for various speech sounds by repeating different phrases repeatedly. The computer learned 39 distinctive sounds and a Chat GPT-style language model was used to translate the signals into intelligible sentences. This was then used to control an avatar with a voice personalized to sound like Ann's voice before the injury, based on a recording of her speaking at her wedding.

The technology was not perfect, decoding words incorrectly 28% of the time in a test run involving more than 500 phrases, and it generated brain-to-text at a rate of 78 words a minute, compared with the 110-150 words typically spoken in natural conversation. However, scientists said the latest advances in accuracy, speed and sophistication suggest the technology is now at a point of being practically useful for patients. A crucial next step is to create a wireless version of the BCI that could be implanted beneath the skull.
The findings have been published in the journal Nature.
Moon

India Becomes the First Country To Land Spacecraft on Moon's South Pole 111

India has become the first country to land a spacecraft on the moon's south pole. It launched Chandrayaan-3 in mid-July, with the spacecraft entering the moon's orbit on Aug. 5. Earlier this week, Russia crashed its Luna-25 rocket in the same lunar region. From a report: It's notoriously difficult to land a rover on the moon. Russia's Luna-25 crashed while making an attempt just this week, while Japanese company ispace failed to land an unmanned lander in April.â 1 Since the moon has no atmosphere, landers can't just softly touch down on the lunar surface. And, without GPS capabilities, scientists rely on the lander's computers to accurately identify where the spacecraft will touch down. India is only the fourth country to pull off a moon landing, behind the U.S., China, and Russia. The nation's lunar aspirations are part of a push by Prime Minister Narendra Modi to garner investments for private space exploration and satellite launches. Speaking at the rocket's launch in July, Modi heralded a "new chapter" in India's space program.
Medicine

Hookworms Successfully Prevent Type 2 Diabetes In Human Trial 126

A two-year human trial conducted by James Cook University (JCU) has concluded, demonstrating positive results using low-dose human hookworm therapy to treat chronic conditions, particularly in relation to type 2 diabetes. New Atlas reports: [O]f the 24 participants who received worms, when offered a dewormer at the end of the second year of the trial, with the option to stay in the study for another 12 months, only one person chose to kill off their gut buddies -- and it was only because they had an impending planned medical procedure. "All trial participants had risk factors for developing cardiovascular disease and type 2 diabetes," said Dr Doris Pierce, from JCU's Australian Institute of Tropical Health and Medicine (AITHM). "The trial delivered some considerable metabolic benefits to the hookworm-treated recipients, particularly those infected with 20 larvae."

In this double-blinded trial, 40 participants aged 27 to 50, with early signs of metabolic diseases, took part. They received either 20 or 40 microscopic larvae of the human hookworm species Necator americanus; another group took a placebo. As an intestinal parasite, the best survival skill is to keep the host healthy, which will provide a long-term stable home with nutrients 'on tap.' In return, these hookworms pay the rent in the form of creating an environment that suppresses inflammation and other adverse conditions that can upset that stable home. While the small, round worms can live for a decade, they don't multiply unless outside the body, and good hygiene means transmission risk is very low.

As for the results, those with 20 hookworms saw a Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) level drop from 3.0 units to 1.8 units within the first year, which restored their insulin resistance to a healthy range. The cohort with 40 hookworms still experienced a drop, from 2.4 to 2.0. Those who received the placebo saw their HOMA-IR levels increase from 2.2 to 2.9 during the same time frame. "These lowered HOMA-IR values indicated that people were experiencing considerable improvements in insulin sensitivity -- results that were both clinically and statistically significant," said Dr Pierce. Those with worms also had higher levels of cytokines, which play a vital role in triggering immune responses.
The study was published in the journal Nature Communications.
Earth

Bacteria That 'Eat' Methane Could Slow Global Heating, Study Finds (theguardian.com) 55

An anonymous reader quotes a report from The Guardian: Methane is a potent greenhouse gas emitted from energy (natural gas and petroleum systems), industry, agriculture, land use and waste management activities. Now a group of researchers from California University Long Beach are proposing a method of removing methane by using a group of bacteria known as methanotrophs to naturally convert methane to carbon dioxide and biomass. All the bacteria in this group "'eat' methane, removing it from air and converting part of it to cells as a source of sustainable protein," according to the lead researcher, Mary E Lidstrom. Lidstrom's team have found a strain of bacteria within this group called methylotuvimicrobium buryatense 5GB1C that can remove methane efficiently even when it is present in lower amounts. If it became widespread, the technology has the potential to help slow global heating, the researchers said.

Typically, this group of bacteria thrive in environments with high levels of methane (between 5,000 and 10,000 parts per million (ppm)). The normal concentrations in our atmosphere have much lower levels of only about 1.9 ppm of methane. But certain areas such as landfills, rice fields and oilwells emit higher concentrations of about 500 ppm. "Bacteria that rapidly eat methane at the higher concentrations found around cattle herds, etc could make a huge contribution to cutting methane emissions, especially from tropical agriculture," said Euan Nisbet, professor of Earth sciences at Royal Holloway, University of London, commenting on the findings of the study.

The strain's high methane consumption rate is probably due to a low energy requirement and greater attraction for methane – more than five times more than that of other bacteria, according to the study. "The bacteria oxidise the methane to CO2 (a much less powerful greenhouse gas) and so you can even use the exhaust to pump into greenhouses and grow tomatoes," said Nisbet. "The biggest barrier to implementation now is technical: we need to increase the methane treatment unit 20-fold. If we can achieve that, then the biggest barriers become investment capital and public acceptance. We believe we could have field pilots tested within three to four years, and scale up would then depend on investment capital and commercialization," said Lidstrom.
The study has been published in the journal Proceedings of the National Academy of Sciences (PNAS).
Space

Target of European Space Debris Removal Mission Is Itself Hit by Space Debris (bloomberg.com) 21

A piece of space debris being monitored by the European Space Agency as part of a mission to remove trash from space was hit by another piece of debris, splintering the object into more pieces. From a report: ESA confirmed Tuesday that the US's 18th Space Defense Squadron, which tracks objects in orbit, spotted a number of new pieces in the vicinity of a payload adapter named VESPA that the agency had planned to pluck from space. The most likely cause of those new fragments is "the hypervelocity impact of a small, untracked object" ramming into VESPA, according to ESA. VESPA was left over from the launch of a European Vega rocket that took off from South America in 2013. It was part of a cone-shaped attachment used to deploy the rocket's satellite into orbit, and has been in Earth's orbit ever since. ESA said its new fragments don't pose much of a risk to any other spacecraft at the moment.

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