Scientists have pinpointed the cause of nausea and vomiting in pregnancy, "finding that the severity of illness is influenced by how much of a hormone called GDF15 the growing fetus makes," reports Science Magazine. The findings have been published in the journal Nature. From the report: GDF15 is present in the blood of nonpregnant people and is known to be associated with nausea; it's also been tested as a weight loss aid because of its tendency to suppress appetite. Levels of the hormone rise sharply in early pregnancy and increase throughout gestation. Pregnant people with higher GDF15 concentrations have been documented as having a higher risk of vomiting and nausea. Some researchers suggest the hormone-caused aversion to some smells and tastes might encourage an expectant parent to avoid foods potentially dangerous to the fetus.

To find out more about GDF15 changes during pregnancy, University of Cambridge physician-scientist Stephen O'Rahilly and colleagues studied half a dozen pregnant people who were known from previous genetic screening to produce a slightly different version of the GDF15 protein from their fetuses. Researchers could take advantage of that difference to trace whether GDF15 in the parent's blood originated in the parental or fetal genome: Almost all of it came from the fetus, O'Rahilly says. The team also took a closer look at the link between GDF15 levels and pregnancy sickness. Consistent with previous research, questionnaires from more than 300 participants showed that people who reported vomiting and nausea had significantly higher levels of circulating GDF15 on average than people without these symptoms. The researchers also found elevated levels of GDF15 in an analysis of more than 50 women hospitalized with hyperemesis gravidarum.

Still, hormone levels alone couldn't explain the difference in sickness severity. "There was a big overlap" in GDF15 levels between the groups, O'Rahilly says. He and co-author Marlena Fejzo, a researcher at the University of Southern California, suspected that people's sensitivity to GDF15 might also play a role. (Fejzo began to study the condition after her own pregnancy loss following hyperemesis gravidarum.) To test the idea, the researchers studied 10 nonpregnant people with a rare genetic variant known to carry a heightened risk of hyperemesis gravidarum. These people had reduced GDF15 levels in their blood, hinting that naturally low levels of the hormone might predispose someone to sickness during pregnancy. The researchers found the opposite when they asked 20 pregnant people with beta thalassemia, a blood disorder associated with high GDF15 levels, about their pregnancy symptoms: Just 5% of this group reported nausea or vomiting. O'Rahilly's lab found a similar pattern in animal experiments.

NASA's Voyager 1 spacecraft is, once again, having trouble transmitting any scientific or systems data back to Earth. "The 46-year-old spacecraft is capable of receiving commands, but a problem seems to have arisen with the probe's computers," reports Space.com. Slashdot readers quonset and ArchieBunker shared the news. From the report: Voyager 1's flight data system (FDS), which collects onboard engineering information and data from the spacecraft's scientific instruments, is no longer communicating as expected with the probe's telecommunications unit (TMU), according to a NASA blog post on Dec. 12. When functioning properly, the FDS compiles the spacecraft's info into a data package, which is then transmitted back to Earth using the TMU. Lately, that data package has been "stuck," the blog post said, "transmitting a repeating pattern of ones and zeros." Voyager's engineering team traced the problem back to the FDS, but it could be weeks before a solution is found. In May 2022, Voyager 1 experienced transmitting issues for several months before a workaround was found. Meanwhile, Voyager 2 experienced an unplanned "communications pause" earlier this year after a routine sequence of commands triggered a 2-degree change in the spacecraft's antenna orientation. This prevented it from receiving commands or transmitting data back to Earth until NASA fixed the issue a week later.

An anonymous reader quotes a report from MIT Technology Review: In a paper published in Nature today, the researchers say it is the first time a large language model has been used to discover a solution to a long-standing scientific puzzle -- producing verifiable and valuable new information that did not previously exist. "It's not in the training data -- it wasn't even known," says coauthor Pushmeet Kohli, vice president of research at Google DeepMind. Large language models have a reputation for making things up, not for providing new facts. Google DeepMind's new tool, called FunSearch, could change that. It shows that they can indeed make discoveries -- if they are coaxed just so, and if you throw out the majority of what they come up with.

FunSearch (so called because it searches for mathematical functions, not because it's fun) continues a streak of discoveries in fundamental math and computer science that DeepMind has made using AI. First Alpha Tensor found a way to speed up a calculation at the heart of many different kinds of code, beating a 50-year record. Then AlphaDev found ways to make key algorithms used trillions of times a day run faster. Yet those tools did not use large language models. Built on top of DeepMind's game-playing AI AlphaZero, both solved math problems by treating them as if they were puzzles in Go or chess. The trouble is that they are stuck in their lanes, says Bernardino Romera-Paredes, a researcher at the company who worked on both AlphaTensor and FunSearch: "AlphaTensor is great at matrix multiplication, but basically nothing else." FunSearch takes a different tack. It combines a large language model called Codey, a version of Google's PaLM 2 that isfine-tuned on computer code, with other systems that reject incorrect or nonsensical answers and plug good ones back in.

The researchers started by sketching out the problem they wanted to solve in Python, a popular programming language. But they left out the lines in the program that would specify how to solve it. That is where FunSearch comes in. It gets Codey to fill in the blanks -- in effect, to suggest code that will solve the problem. A second algorithm then checks and scores what Codey comes up with. The best suggestions -- even if not yet correct -- are saved and given back to Codey, which tries to complete the program again. After a couple of million suggestions and a few dozen repetitions of the overall process -- which took a few days -- FunSearch was able to come up with code that produced a correct and previously unknown solution to the cap set problem, which involves finding the largest size of a certain type of set. Imagine plotting dots on graph paper. [...] To test its versatility, the researchers used FunSearch to approach another hard problem in math: the bin packing problem, which involves trying to pack items into as few bins as possible. This is important for a range of applications in computer science, from data center management to e-commerce. FunSearch came up with a way to solve it that's faster than human-devised ones.

The Economist reports: "Shake, shake, shake, shake," Taylor Swift sings from the stage of Lumen Field in Seattle at 10.35 in the evening on July 22nd. The fans respond, enthusiastically; the stadium duly shakes; a nearby seismometer takes note. To pop aficionados "Shake it off" is an empowering up-tempo anthem played at 160 beats per minute. To the Pacific Northwest Seismic Network, which is designed to monitor earthquakes, it is a 2.6 hertz signal in which the amplitude of the acceleration was as large as one centimetre per second, per second.

The well-situated seismometer first came to public attention in January 2011, when it recorded the response of fans of the Seattle Seahawks, an American football team, to a magnificent touchdown by Marshawn Lynch, a running back known as "Beast Mode." The "Beast Quake" went down in local sporting history. When Ms Swift came to town for two nights of her Eras tour, Jacqueline Caplan-Auerbach, a geology professor at Western Washington University, used the opportunity to learn more about how events in the stadium shake its surroundings. On December 11th she presented some of her conclusions at the American Geophysical Union's autumn meeting in San Francisco.

[...] Dr Caplan-Auerbach wanted to see whether such resonant amplification might also be at play elsewhere, and to distinguish between the effect of the music itself and the audience's response. Her concert-night data showed two distinct sets of signals, one in higher frequencies (30-80hz), one in lower frequencies (1-8hz). The higher-frequency signals were present during the sound check, when the band were on stage but the stadium empty, and absent during the concerts' "surprise songs," played without the band by Ms Swift alone. The lower frequencies were absent when the audience had yet to arrive. Clearly those higher frequencies were from the music itself.

sciencehabit shares a report from Science Magazine: Grunge music: a source of validation for a generation of disaffected youth. And a surprising source of scientific inspiration for Earl Bellinger of the Max Planck Institute for Astrophysics. While listening to Soundgarden's 1994 hit Black Hole Sun 2 years ago, he contemplated a curious question: Might itty-bitty black holes from the dawn of time be lurking in the hearts of giant stars? A new study by Bellinger and colleagues suggests the idea is not so far-fetched. Astronomers could detect these trapped black holes by the vibrations they cause on the star's surface. And if there's enough of them out there, they could function as the mysterious dark matter that holds the universe together.

The researchers found that the black holes would sink to the star's core where hydrogen atoms undergo fusion to produce heat and light. At first, very little would happen. Even a dense stellar core is mostly empty space. The most microscopic of the black holes would have a hard time finding matter to consume and its growth would be extremely slow, Bellinger says. "It could take longer than the lifetime of the universe to eat the star." But larger ones, roughly as massive as the asteroid Ceres or the dwarf planet Pluto, would get bigger on timescales of only a few hundred million years. Material would spiral onto the black hole, forming a disk that would heat up through friction and emit radiation. Once the black hole was about as massive as Earth, it would produce significant amounts of radiation, shining brightly and churning up the star's core like pot of boiling water. "It will become a black hole -- powered object rather than fusion-powered object," says study co-author Matt Caplan, a theoretical physicist at Illinois State University. He and his colleagues have dubbed these entities "Hawking stars."

The European Space Agency's Gaia satellite has spotted about 500 such anomalously cool giant stars, known as red stragglers, Bellinger says. To figure out whether these might actually be hiding a black hole, he says, astronomers could tune in to the particular frequencies at which the stars vibrate. Because a Hawking star would churn throughout its interior, rather than just in the topmost layers like an ordinary red giant, it would be expected to thrum with a particular combination of frequencies. Such waves can be detected in the way the star's light pulses and throbs. Bellinger is applying for funding to study the known red stragglers and see whether any display the characteristic vibrations of a black hole. The study has been published in The Astrophysical Journal.

An anonymous reader quotes a report from MIT Technology Review: Brain organoids, clumps of human brain cells grown in a dish, can be hooked up to an electronic chip and carry out simple computational tasks, a new study shows. Feng Guo and his team at Indiana University Bloomington generated a brain organoid from stem cells, attached it to a computer chip, and connected their setup, known as Brainoware, to an AI tool. They found that this hybrid system could process, learn, and remember information. It was even able to carry out some rudimentary speech recognition. The work, published today in Nature Electronics, could one day lead to new kinds of bio-computers that are more efficient than conventional computers.

"This is a first demonstration of using brain organoids [for computing]," says Guo. "It's exciting to see the possibilities of organoids for biocomputing in the future." With Brainoware, Guo aimed to use actual brain cells to send and receive information. When the researchers applied electrical stimulation to the hybrid system they'd built, Brainoware responded to those signals, and changes occurred in its neural networks. According to the researchers, this result suggests that the hybrid system did process information, and could perhaps even perform computing tasks without supervision. Guo and his colleagues then attempted to see if Brainoware could perform any useful tasks. In one test, they used Brainoware to try to solve mathematical equations. They also gave it a benchmark test for speech recognition, using 240 audio clips of eight people pronouncing Japanese vowels. The clips were converted into electrical signals and applied to the Brainoware system. This generated signals in the neural networks of the brain organoid, which were then fed into an AI tool for decoding.

The researchers found that the brain organoid -- AI system could decode the signals from the audio recordings, which is a form of speech recognition, says Guo. "But the accuracy was low," he says. Although the system improved with training, reaching an accuracy of about 78%, it was still less accurate than artificial neural networks, according to the study. Lena Smirnova, an assistant professor of public health at Johns Hopkins University, points out that brain organoids do not have the ability to truly hear speech but simply exhibit "a reaction" to pulses of electrical stimulation from the audio clips. And the study did not demonstrate whether Brainoware can process and store information over the long term or learn multiple tasks. Generating brain cell cultures in a lab and maintaining them long enough to perform computations is also a huge undertaking. Still, she adds, "it's a really good demonstration that shows the capabilities of brain organoids."

An anonymous reader shares a report: This year has been marked by many terrifying things, but perhaps the most surprising of the 2023 horrors was ... eye drops. The seemingly innocuous teeny squeeze bottle made for alarming headlines numerous times during our current revolution around the sun, with lengthy lists of recalls, startling factory inspections, and ghastly reports of people developing near-untreatable bacterial infections, losing their eyes and vision, and dying.

Recapping this unexpected threat to health, the Food and Drug Administration on Tuesday released an advisory titled "What You Should Know about Eye Drops" in hopes of keeping the dangers of this year from leaking into the next. Among the notable points from the regulator was this stark pronouncement: No one should ever use any homeopathic ophthalmic products, and every single such product should be pulled off the market. The point is unexpected, given that none of the high-profile infections and recalls this year involved homeopathic products. But, it should be welcomed by any advocates of evidence-based medicine.

For the first time, scientists have discovered nuclear fission occurring amongst the stars, supporting the idea that neutron stars create "superheavy" elements when they collide, which then break down via nuclear fission to birth rare elements. Space.com reports: Nuclear fission is basically the opposite of nuclear fusion. While nuclear fusion refers to the smashing of lighter elements to create heavier elements, nuclear fission is a process that sees energy released when heavy elements split apart to create lighter elements. Nuclear fission is pretty well known, too. It's actually the basis of energy-generating nuclear power plants here on Earth -- however, it had not been seen occurring amongst the stars before now.

The team of researchers led by North Carolina State University scientist Ian Roederer searched data concerning a wide range of elements in stars to discover the first evidence that nuclear fission could therefore be acting when neutron stars merge. These findings could help solve the mystery of where the universe's heavy elements come from. Scientists know that nuclear fusion is not just the primary source of energy for stars, but also the force that forges a variety of elements, the "heaviest" being iron.

The evidence of nuclear fission discovered by [Matthew Mumpower, research co-author and a scientist at Los Alamos National Laboratory] and the team comes in the form of a correlation between "light precision metals," like silver, and "rare earth nuclei," like europium, showing in some stars. When one of these groups of elements goes up, the corresponding elements in the other group also increases, the scientists saw. The team's research also indicates that elements with atomic masses -- counts of protons and neutrons in an atomic nucleus -- greater than 260 may exist around neutron star smashes, even if this existence is brief. This is much heavier than many of the elements at the "heavy end" of the periodic table. "The only plausible way this can arise among different stars is if there is a consistent process operating during the formation of the heavy elements," Mumpower said. "This is incredibly profound and is the first evidence of fission operating in the cosmos, confirming a theory we proposed several years ago."

"As we've acquired more observations, the cosmos is saying, 'hey, there's a signature here, and it can only come from fission.'"

The research was published in the journal Science.

A new study from the University of Warwick found that artificial intelligence can analyze X-rays and diagnose medical issues better than doctors. The BBC reports: Software was trained using chest X-rays from more than 1.5m patients, and scanned for 37 possible conditions. It was just as accurate or more accurate than doctors' analysis at the time the image was taken for 35 out of 37 conditions, the University of Warwick said. The AI could reduce doctors' workload and delays in diagnosis, and offer radiologists the "ultimate second opinion," researchers added. The software understood that some abnormalities for which it scanned were more serious than others, and could flag the most urgent to medics, the university said.

To check the results were accurate, more than 1,400 X-rays analysed by the software were cross-examined by senior radiologists. They then compared the diagnoses made by the AI with those made by radiologists at the time. The software, called X-Raydar, removed human error and bias, said lead author, Dr Giovanni Montana, Professor of Data Science at Warwick University. "If a patient is referred for an X-ray with a heart problem, doctors will inevitably focus on the heart over the lungs," he said. "This is totally understandable but runs the risk of undetected problems in other areas".

An anonymous reader quotes a report from Ars Technica: Thirty years ago, a botanist in Germany had a simple wish: to see the inner workings of woody plants without dissecting them. By bleaching away the pigments in plant cells, Siegfried Fink managed to create transparent wood, and he published his technique in a niche wood technology journal. The 1992 paper remained the last word on see-through wood for more than a decade, until a researcher named Lars Berglund stumbled across it. Berglund was inspired by Fink's discovery, but not for botanical reasons. The materials scientist, who works at KTH Royal Institute of Technology in Sweden, specializes in polymer composites and was interested in creating a more robust alternative to transparent plastic. And he wasn't the only one interested in wood's virtues. Across the ocean, researchers at the University of Maryland were busy on a related goal: harnessing the strength of wood for nontraditional purposes.

Now, after years of experiments, the research of these groups is starting to bear fruit. Transparent wood could soon find uses in super-strong screens for smartphones; in soft, glowing light fixtures; and even as structural features, such as color-changing windows. "I truly believe this material has a promising future," says Qiliang Fu, a wood nanotechnologist at Nanjing Forestry University in China who worked in Berglund's lab as a graduate student. Wood is made up of countless little vertical channels, like a tight bundle of straws bound together with glue. These tube-shaped cells transport water and nutrients throughout a tree, and when the tree is harvested and the moisture evaporates, pockets of air are left behind. To create see-through wood, scientists first need to modify or get rid of the glue, called lignin, that holds the cell bundles together and provides trunks and branches with most of their earthy brown hues. After bleaching lignin's color away or otherwise removing it, a milky-white skeleton of hollow cells remains. This skeleton is still opaque, because the cell walls bend light to a different degree than the air in the cell pockets does -- a value called a refractive index. Filling the air pockets with a substance like epoxy resin that bends light to a similar degree to the cell walls renders the wood transparent.

The material the scientists worked with is thin -- typically less than a millimeter to around a centimeter thick. But the cells create a sturdy honeycomb structure, and the tiny wood fibers are stronger than the best carbon fibers, says materials scientist Liangbing Hu, who leads the research group working on transparent wood at the University of Maryland in College Park. And with the resin added, transparent wood outperforms plastic and glass: In tests measuring how easily materials fracture or break under pressure, transparent wood came out around three times stronger than transparent plastics like Plexiglass and about 10 times tougher than glass. "The results are amazing, that a piece of wood can be as strong as glass," says Hu, who highlighted the features of transparent wood in the 2023 Annual Review of Materials Research.

Meghan Bartels reports via Scientific American: Some sky watchers this month will witness Betelgeuse, one of the brightest and best-known stars in the sky, nearly disappear. Mere seconds later -- despite astronomers' hopes that the star will meet its explosive end someday soon -- it will return, shining just as brightly as ever. Betelgeuse's brief blip of obscurity will mark a cosmic coincidence: an asteroid will block the star from view over a thin strip of Earth's surface. Scientists are hailing this celestial alignment as a once-in-a-lifetime occasion that, they hope, will permit them to glimpse Betelgeuse's ever changing surface of hot and cold patches in the best resolution to date. The opportunity comes courtesy of a sizable asteroid called Leona, which astronomers first spotted in 1891. On its own, Leona is just another space rock cluttering up the asteroid belt between Mars and Jupiter. But at 8:17 P.M. ET on December 11 Leona will slip directly between Earth and Betelgeuse, a red supergiant star that, unlike the asteroid, has been recognized by countless generations of humans around the world. [...]

To understand how special the event is, consider the total solar eclipse that will occur in April 2024. During the climax of the eclipse, viewers across a narrow strip of Earth's surface will see the moon pass directly in front of the sun. Because the two bodies appear as the same size in our sky, the moon will entirely block the visible disk of the sun and expose the faint, wispy halo called the corona, a layer of our home star's atmosphere that scientists otherwise cannot see from Earth. Similarly, the roughly 40-mile-wide Leona appears in the sky as about the same size as the enormous but very distant Betelgeuse. This will allow the asteroid to block all or most of the star's light when the two bodies perfectly align. But whereas Earth experiences a total solar eclipse every 18 months or so, occultations of bright stars such as Betelgeuse are extremely rare, occurring less than once a century [...].

Long-time Slashdot reader schwit1 shared an interesting article from ScienceAlert: Undersea volcanic eruptions account for more than three-quarters of all volcanism on Earth, but rarely do we see the impacts. The Hunga Tonga-Hunga Ha'apai eruption of 2022 was a dramatic exception. Its furious explosion from shallow waters broke the ocean surface and punched through the stratosphere, generating supercharged lighting and an atmospheric shock wave that circled the globe several times.

But there was far more to the fallout than satellite images could possibly capture or observers could report. We know the human toll this explosion took, but now a new study investigating the underwater impacts of the Hunga-Tonga eruption has detailed just how ferociously the explosion tore open the seafloor, ripped up undersea cables, and smothered marine life... The team also compiled a trove of data from ship-based sonar, sediment cores, geochemical analyses, water column samples, and video footage to chart the devastatingly powerful upheaval...

Their analyses show at least 6 cubic kilometers (km3) of seafloor was lost from within the caldera — 20 times the eruptive volume of the 1980 Mount St. Helens eruption — and an additional 3.5 km3 of material was blasted out of the Hunga volcano's submerged flanks... That leaves roughly four-fifths of the ejected material in the ocean; material that was funneled into fast-moving density flows that scoured out tracks 30 meters deep in the seafloor and accumulated 22 meters (72 feet) thick in some places.

"The United States military is preparing to launch its secretive X-37B space plane on a seventh mission in orbit," reports NBC News.

Shaped like a small space shuttle, "It's an itty-bitty spaceplane, not quite 30 feet long and under 10 feet tall," writes the Washington Post, "with a pair of stubby wings and a rounded, bulldog-like nose." Space.com says the launch window for the uncrewed vehicle opens Monday at 8:14 p.m. EST.

From NBC News: For the first time, the X-37B will ride into orbit atop a SpaceX Falcon Heavy rocket. Since its debut more than a decade ago, the X-37B has been a source of intrigue within the space community, mostly owing to the mysterious nature of its activities in low Earth orbit. Despite not knowing its true purpose or location, skywatchers have occasionally spotted and photographed the space plane in the night sky using telescopes... The military is tight-lipped about such operations, but the Space Force said the X-37B missions "are key to ensuring safe and responsible operations in space for all users of the space domain..."
The "U.S. Space Force says that launching on SpaceX's Falcon Heavy rocket will allow testing "in new orbital regimes, experimenting with space domain awareness technologies and investigating the radiation effects to NASA materials."

The Washington Post notes that "The reference about 'space domain awareness' could mean that it will be keeping an eye on other satellites, potentially watching for threats": At least one part of the mission is known. The vehicle will "expose plant seeds to the harsh radiation environment of long-duration spaceflight" in an experiment for NASA. In the past, the Pentagon has also used the X-37B to test some of its cutting edge technologies, including a small solar panel designed to transform solar energy into microwaves, a technology that one day could allow energy harnessed in space to be beamed back to Earth...

If Sunday's X-37B mission is like previous ones, the spaceplane could be in space for a while. Its first flight, which launched in 2010, lasted 224 days.

Every five years America's federal Department of Health updates its dietary guidelines with the latest nutrition science, affecting federal nutrition programs and various other government health initiatives.

Now an anonymous reader shared this report from the Wall Street Journal: Botanists count potatoes as a vegetable. But should Americans? The U.S. Dietary Guidelines Advisory Committee has sparked the question... White potatoes, which come in various colors, are classified as "starchy vegetables." But the committee could uproot potatoes from the vegetable bin and toss them in with a broader category of rice, other grains and carbohydrates as the Departments of Agriculture and Health and Human Services weigh updates to national diet guidelines for 2025.

The scientific debate isn't easy to follow. But it sounds like a half-baked idea to Kam Quarles, chief executive of the National Potato Council, a potato-industry group. The dietary guidelines shape nutrition advice to Americans, as well as what foods are served in school cafeterias. Potatoes, according to Quarles, should be respected as a gateway vegetable. "Kids are far more likely to eat" dishes with other vegetables if potatoes are involved, he said.

Not all parents swallow that a trail of tubers leads to leafy greens. Some complained about a Peppa Pig animated cartoon that featured a potato preaching the nutritional value of vegetables. "By the power of vegetables, I am here," Super Potato said, soaring through the sky, singing, "Fruit and vegetables keep us alive. Always remember to eat your five." The U.K.'s National Health Service, for one, doesn't count spuds toward the U.K.'s recommended five portions of fruits and vegetables a day. "It's a giant spud singing it. You're, like, 'Really? A potato's one of your five a day?'" said Dan Greef, the owner of Deliciously Guilt Free, a sugar-free bakery in Cambridge, U.K. He spent years persuading his two children to eat vegetables. Then, he said, "a drawing of a potato tells you it's fine, and you don't listen to your dad...."

Nutrition researchers say the potato contains helpful nutrients, including potassium and vitamin C, but its health benefits are diminished when it is fried. Nearly half of all U.S. potatoes eaten as food go into frozen products, mostly french fries, the USDA found.
For comparison, the article points out that under U.S. dietary guidelines, "corn on the cob is a starchy vegetable, while cornmeal is a grain."

An anonymous reader quotes a report from STAT: The Food and Drug Administration on Friday approved the world's first medicine based on CRISPR gene-editing technology, a groundbreaking treatment for sickle cell disease that delivers a potential cure for people born with the chronic and life-shortening blood disorder. The new medicine, called Casgevy, is made by Vertex Pharmaceuticals and CRISPR Therapeutics. Its authorization is a scientific triumph for the technology that can efficiently and precisely repair DNA mutations -- ushering in a new era of genetic medicines for inherited diseases.

In a clinical trial, Casgevy was shown to eliminate recurrent episodes of debilitating pain caused by sickle cell, which afflicts approximately 100,000 people in the U.S., a vast majority of whom are Black. The therapy, whose scientific name is exa-cel, is described as a potential cure because the genetic fix enabled by CRISPR is designed to last a lifetime, although confirmation will require years of follow-up. The FDA decision comes three weeks after regulators in the U.K. were the first to clear the drug. Approval in the European Union is expected next year. The FDA is also expected to rule on exa-cel as a treatment for beta thalassemia, another inherited blood disorder, by March 30.

The FDA on Friday also approved another sickle cell treatment, a gene therapy from Bluebird Bio called Lyfgenia. Patients will now have the option of two cutting-edge therapies that provide potentially curative benefits. Scientists Emmanuelle Charpentier and Jennifer Doudna published their first CRISPR paper just over a decade ago. In 2020, the research won the pair a Nobel Prize. Reflecting on the approval of Casgevy, Charpentier told STAT via email that she was "excited and pleased" for what it means for patients and their families.

The Biden administration is threatening to cancel the patents of some costly medications to allow rivals to make their own more affordable versions. The Associated Press reports: Under a plan announced Thursday, the government would consider overriding the patent for high-priced drugs that have been developed with the help of taxpayer money and letting competitors make them in hopes of driving down the cost. In a 15-second video released to YouTube on Wednesday night, President Joe Biden promised the move would lower prices. "Today, we're taking a very important step toward ending price gouging so you don't have to pay more for the medicine you need," he said.

White House officials would not name drugs that might potentially be targeted. The government would consider seizing a patent if a drug is only available to a "narrow set of consumers," according to the proposal that will be open to public comment for 60 days. Drugmakers are almost certain to challenge the plan in court if it is enacted. [...] The White House also intends to focus more closely on private equity firms that purchase hospitals and health systems, then often whittle them down and sell quickly for a profit. The departments of Justice and Health and Human Services, and the Federal Trade Commission will work to share more data about health system ownership.

While only a minority of drugs on the market relied so heavily on taxpayer dollars, the threat of a government "march-in" on patents will make many pharmaceutical companies think twice, said Jing Luo, a professor of medicine at University of Pittsburgh. "If I was a drug company that was trying to license a product that had benefited heavily from taxpayer money, I'd be very careful about how to price that product," Luo said. "I wouldn't want anyone to take my product away from me."

An anonymous reader quotes a report from Motherboard: Researchers have identified previously unknown elements of whale vocalizations that may be analogous to human speech, a new study reports. Sperm whales are giants of the deep, with healthy adults having no known predators. Scientists studying their vocalizations have already picked out key elements of their communication, namely clicks, sequences of which are called codas. Now, researchers led by Gasper Beus from the University of California, Berkeley report the discovery that the acoustic properties of these clicks -- for example, pitch -- are "on many levels analogous to human vowels and dipthongs," which is when one vowel sound morphs into another such as in the word "coin." The researchers even identify two unique "coda vowels" that are "actively exchanged" in conversation between whales, which they term the a-vowel and i-vowel.

The researchers explain in their paper, published as a preprint online this week, that the first clue that so-called spectral properties could be meaningful for whale speech was provided by AI. Beus previously developed a deep learning model for human language called fiwGAN which "was trained to imitate sperm whale codas and embed information into these vocalizations." Not only did the AI predict elements of whale vocalizations already thought to be meaningful, such as clicks, but it also singled out acoustic properties. To follow up on the AI's tip, the researchers analyzed a dataset of 3948 sperm whale codas recorded with hydrophones placed directly on whales between 2014 and 2018. They only analyzed one channel from the hydrophones to control for underwater effects and whale movement, and removed click timing from their visualization to better isolate patterns in the acoustic properties themselves.

These visualizations vindicated the AI's prediction: The whales reliably exchanged codas with one or two formants -- frequency peaks in the sound wave -- below the 10kHz range. The researchers termed these codas "vowels," with single-formant codas being a-vowels and two-formant codas being i-vowels. "This is by analogy to human vowels which differ in their formant frequencies," the authors wrote. They also identified upward and downward frequency "trajectories" in these codas, which they considered analogous to dipthongs in human language. Considering that these coda vowel patterns were very distinct and not intermixed, plus the existence of dipthongs, the researchers argue that whales are controlling the frequency of their vocalizations.

Record-breaking land and sea temperatures, driven by climate breakdown, will probably cause "unprecedented mass coral bleaching and mortality" throughout 2024, according to a pioneering coral scientist. From a report: The impact of climate change on coral reefs has reached "uncharted territory," said Prof Ove Hoegh-Guldberg, from the University of Queensland, Australia, leading to concerns that we could be at a "tipping point."

The upper ocean is undergoing unmatched changes in conditions, ecosystems and communities that can be traced back to the 1980s, when mass coral bleaching first appeared. In a paper published in the journal Science, US and Australian researchers say that historical data on sea surface temperatures, over four decades, suggests that this year's extreme marine heatwaves may be a precursor to a mass bleaching and coral mortality event across the Indo-Pacific in 2024-25.

Mass coral bleaching happens when delicate corals become stressed due to factors including heat, causing them to lose their brown microbial algae, turning them white. At low stress levels, the algae can return to corals over a few months. But many Caribbean reef areas have recently experienced historically high sea temperatures that began one or two months earlier and lasted longer than usual. Crucially, 2023 is the first year of a potential pair of El Nino years, with the warmest average global surface sea temperature from February to July on record. Since 1997, every instance of these El Nino pairs has led to a global mass coral bleaching event.

Particle physicists should begin laying the groundwork for a revolutionary particle collider that could be built on American soil, a committee of scientists wrote in a draft report on the future of particle physics released on Thursday. From a report: The machine would collide tiny, point-like particles called muons, which resemble electrons but are more massive. Muons provide more bang for the buck than the protons used in the Large Hadron Collider at CERN, and would push the search for new forces and particles deeper than ever into the unknown. The siting of such a project, perhaps at the Fermi National Accelerator Laboratory in Illinois, would restore American particle physics to a position of pre-eminence that was ceded to Europe in 1993 when Congress canceled the giant Superconducting Super Collider. But it will take at least 10 years to demonstrate that the muon collider could work and how much it would cost.

"This is our muon shot," the committee, charged with outlining a vision for the next decade of American particle physics, said in a draft report titled "Exploring the Quantum Universe: Pathways to Innovation and Discovery in Particle Physics." The draft is being presented and discussed at a meeting in Washington, D.C., on Thursday and Friday, and at Fermilab next week. The draft report also highlighted a need to invest in next-generation experiments probing the nature of subatomic particles called neutrinos; the cosmic microwave background, relic radiation from the Big Bang; and dark matter, the gravitational glue holding galaxies together. The panel also recommended participating in a future facility in either Europe or Japan, dedicated to studying the Higgs boson, the discovery of which in 2012 was key for understanding how other particles get their mass.

"The size of the universe we now see as 14 billion light-years across was actually smaller than the size of a nucleus" early in cosmic time, said Hitoshi Murayama, a physicist at the University of California, Berkeley, who led the committee. "So our field is actually not just looking for the fundamental constituents, but getting a bigger picture of how the universe works as whole." The committee, formally known as the Particle Physics Project Prioritization Panel, or P5, was tasked by the U.S. Department of Energy and the National Science Foundation to lay out a road map for the future of the field. The three-year process began by soliciting input from the particle physics community at large, and the final report will serve as a recommendation for what national agencies should prioritize over the next decade.

In an exclusive interview with PetaPixel, astronaut Don Pettit reveals the changes that Nikon makes to its firmware especially for NASA. From the report: Galactic cosmic rays are high-energy particles that originate from outside the solar system that likely come from explosive events such as a supernova. They are bad news for cameras in space -- damaging the sensor and spoiling photos -- so Nikon made special firmware for NASA to limit the harm. Pettit tells PetaPixel that Nikon changed the in-camera noise reduction settings to battle the cosmic rays -- noise is unwanted texture and blur on photos.

Normal cameras have in-camera noise reduction for exposures equal to or longer than one second. This is because camera manufacturers don't think photographers need noise reduction for shorter exposures because there's no noise to reduce. But in space, that's not true. "Our cameras in space get sensor damage from galactic cosmic rays and after about six months we replace all the cameras but you still have cameras with significant cosmic ray damage," explains Pettit. "It shows up at fast shutter speeds, not just the slow ones. So we got Nikon to change the algorithm so that it can do in-camera noise reduction at shutter speeds of up to 500th of a second."

Pettit says Nikon's in-camera noise reduction "does wonders" for getting rid of the cosmic ray damage and that "trying to get rid of it after the fact is really difficult." That's not the only special firmware feature that Nikon makes for NASA; photographers who shoot enough photos know that the file naming system resets itself eventually which is no good for the space agency's astronauts. "The file naming system on a standard digital system will repeat every so often and we can't have two pictures with the same number," explains Pettit. "We'll take half a million pictures with the crew on orbit and so Nikon has changed the way the RAW files are numbered so that there will be no two with the same file number." The report notes that NASA started using Nikon film cameras in 1971, shortly after the Apollo era; "in part because Nikon is so good at making custom modifications that help the astronauts." Previously, the agency used boxy, black Hasselblad cameras.