A spacecraft containing pharmaceutical drugs that were grown on orbit has finally returned to Earth today after more than eight months in space. From a report: Varda Space Industries' in-space manufacturing capsule, called Winnebago-1, landed in the Utah desert at around 4:40 p.m. EST. Inside the capsule are crystals of the drug ritonavir, which is used to treat HIV/AIDS. It marks a successful conclusion of Varda's first experimental mission to grow pharmaceuticals on orbit, as well as the first time a commercial company has landed a spacecraft on U.S. soil, ever. The capsule will now be sent back to Varda's facilities in Los Angeles for analysis, and the vials of ritonavir will be shipped to a research company called Improved Pharma for post-flight characterization, Varda said in a statement. The company will also be sharing all the data collected through the mission with the Air Force and NASA, per existing agreements with those agencies.

The first-of-its-kind reentry and landing is also a major win for Rocket Lab, which partnered with Varda on the mission. Rocket Lab hosted Varda's manufacturing capsule inside its Photon satellite bus; through the course of the mission, Photon provided power, communications, attitude control and other essential operations. At the mission's conclusion, the bus executed a series of maneuvers and de-orbit burns that put the miniature drug lab on the proper reentry trajectory. The final engine burn was executed shortly after 4 p.m. EST. Photon burned up in the atmosphere as planned while the capsule, protected by a heat shield and with the aid of a parachute, continued to land.

In a warning issued Wednesday, the FDA said it has not authorized or approved any smartwatch or smart ring to measure blood glucose levels. The use of these devices can lead to inaccurate measurements and errors in managing diabetes that can be life-threatening, the agency said. From a report: These unauthorized devices are different from smartwatch apps that display data from FDA-approved continuous glucose monitoring devices that pierce the skin. The FDA did not name specific brands but said the sellers of these unauthorized smartwatches and smart rings advertise using âoenon-invasive techniquesâ to measure blood glucose without requiring people to prick their fingers or pierce their skin. However, these devices do not directly test blood glucose levels, the agency said, urging consumers to avoid buying them for that purpose.

The agency also advised health care providers to discuss the risk of using unauthorized blood glucose measuring devices with their patients and to help them select an appropriate authorized device for their needs. âoeThe agency is working to ensure that manufacturers, distributors, and sellers do not illegally market unauthorized smartwatches or smart rings that claim to measure blood glucose levels,â the FDA said in the statement. âoeIf your medical care depends on accurate blood glucose measurements, talk to your health care provider about an appropriate FDA-authorized device for your needs." .

An anonymous reader quotes a report from Princeton Engineering: In the blink of an eye, the unruly, superheated plasma that drives a fusion reaction can lose its stability and escape the strong magnetic fields confining it within the donut-shaped fusion reactor. These getaways frequently spell the end of the reaction, posing a core challenge to developing fusion as a non-polluting, virtually limitless energy source. But a Princeton-led team composed of engineers, physicists, and data scientists from the University and the Princeton Plasma Physics Laboratory (PPPL) have harnessed the power of artificial intelligence to predict -- and then avoid -- the formation of a specific plasma problem in real time.

In experiments at the DIII-D National Fusion Facility in San Diego, the researchers demonstrated their model, trained only on past experimental data, could forecast potential plasma instabilities known as tearing mode instabilities up to 300 milliseconds in advance. While that leaves no more than enough time for a slow blink in humans, it was plenty of time for the AI controller to change certain operating parameters to avoid what would have developed into a tear within the plasma's magnetic field lines, upsetting its equilibrium and opening the door for a reaction-ending escape.

"By learning from past experiments, rather than incorporating information from physics-based models, the AI could develop a final control policy that supported a stable, high-powered plasma regime in real time, at a real reactor," said research leader Egemen Kolemen, associate professor of mechanical and aerospace engineering and the Andlinger Center for Energy and the Environment, as well as staff research physicist at PPPL. The research opens the door for more dynamic control of a fusion reaction than current approaches, and it provides a foundation for using artificial intelligence to solve a broad range of plasma instabilities, which have long been obstacles to achieving a sustained fusion reaction. The team published their findings in the journal Nature.

Following a recent ruling from the state supreme court, the University of Alabama at Birmingham health system said it is pausing all in vitro fertilization (IVF) treatments for fear of criminal prosecution or punitive damages. On Friday, the Alabama Supreme Court ruled that frozen embryos are "children," entitled to full personhood rights, and anyone who destroys them could be liable in a wrongful death case. The Hill reports: "We are saddened that this will impact our patients' attempt to have a baby through IVF, but we must evaluate the potential that our patients and our physicians could be prosecuted criminally or face punitive damages for following the standard of care for IVF treatments," the health system said. [...] It is standard practice in IVF to fertilize several eggs and then transfer one into a woman's uterus. Any remaining normally developing embryos can be, at the patient's request and consent, frozen for later use. But legal experts say it's unclear if the standard practice is illegal in Alabama and could make IVF virtually inaccessible in the state.

According to the American Society of Reproductive Medicine, the best-developing embryo will be transferred into a patient for an attempt at a pregnancy while the rest are frozen for later use, in case the first one does not develop into a live birth, or the patient later desires another child. According to the Centers for Disease Control and Prevention, approximately 238,126 patients underwent IVF treatment in 2021, resulting in the births of 97,128 babies, the last year for which statistics were available. There are 453 IVF clinics nationwide.

Medical alarms don't have to be louder to be more effective. Scientific American: Beeping alarms in hospitals are a life-or-death matter -- but with so many going off all the time, medical professionals may experience alarm fatigue that impairs care. Researchers now report that changing an alarm's sound to incorporate properties of musical instruments can make it more helpful amid the din. Auditory alarms can sound up to 300 times a day per patient in U.S. hospitals, but only a small fraction require immediate action.

Data from the U.S. Food and Drug Administration suggest that alarm fatigue (including when clinicians turned off or forgot to restart alarms) and other alarm-related issues were linked to 566 deaths over five and a half years. After a typical day at the hospital, "I'd leave with beeping in my ears," says Vanderbilt University Medical Center anesthesiologist Joseph Schlesinger. He collaborated with Michael Schutz, a music cognition researcher at McMaster University in Ontario, to analyze how musical sounds could improve hospital alarms.

In 2015 Schutz and Schlesinger began examining musical qualities called timbres that might let softer sounds command attention from busy clinicians. They found that sounds with a "percussive" timbre, many of which contain short bursts of high-frequency energy -- such as wineglasses clinking -- stand out even at low volume. In contrast, loud, "flat" tones that lack high-frequency components, like a reversing truck's beep, get lost. The researchers have since conducted experiments in which participants evaluate different sounds and melodies for annoyance, detectability and recognizability. For a recent study detailed in Perioperative Care and Operating Room Management, the researchers played participants the same sequences of notes with varying timbres. They found the sounds that made these sequences least annoying, with no decrease in recall, were percussive and had complex, time-varied harmonic overtones (the many components within a single sound) like a xylophone's ping, rather than a few homogeneous ones like monotonous mechanical beeps.

The first human patient implanted with a brain-chip from Neuralink appears to have fully recovered and is able to control a computer mouse using their thoughts, the startup's founder Elon Musk said late on Monday. From a report: "Progress is good, and the patient seems to have made a full recovery, with no ill effects that we are aware of. Patient is able to move a mouse around the screen by just thinking," Musk said in a Spaces event on social media platform X. Musk said Neuralink was now trying to get as many mouse button clicks as possible from the patient. The firm successfully implanted a chip on its first human patient last month, after receiving approval for human trial recruitment in September.

The brightest known object in the universe, a quasar 500tn times brighter than our sun, was "hiding in plain sight," researchers say. From a report: Australian scientists spotted a quasar powered by the fastest growing black hole ever discovered. Its mass is about 17bn times that of our solar system's sun, and it devours the equivalent of a sun a day. The light from the celestial object travelled for more than 12bn years to reach Earth. Australian National University scientists first spotted it using a 2.3-metre telescope at the university's NSW Siding Spring Observatory in Coonabarabran. They then confirmed the find using the European Southern Observatory's (ESO's) Very Large Telescope, which has a primary mirror of 8 metres. The findings by the ANU researchers, in collaboration with the ESO, the University of Melbourne, and France's Sorbonne Universite have been published in Nature Astronomy.

The great libraries of the ancient classical world are "legendary... said to have contained stacks of texts," writes ScienceAlert. But from Rome to Constantinople, Athens to Alexandria, only one collection survived to the present day.

And here in 2024, "we can now start reading its contents." A worldwide competition to decipher the charred texts of the Villa of Papyri — an ancient Roman mansion destroyed by the eruption of Mount Vesuvius — has revealed a timeless infatuation with the pleasures of music, the color purple, and, of course, the zingy taste of capers. The so-called Vesuvius challenge was launched a few years ago by computer scientist Brent Seales at the University of Kentucky with support from Silicon Valley investors. The ongoing 'master plan' is to build on Seales' previous work and read all 1,800 or so charred papyri from the ancient Roman library, starting with scrolls labeled 1 to 4.

In 2023, the annual gold prize was awarded to a team of three students, who recovered four passages containing 140 characters — the longest extractions yet. The winners are Youssef Nader, Luke Farritor, and Julian Schilliger. "After 275 years, the ancient puzzle of the Herculaneum Papyri has been solved," reads the Vesuvius Challenge Scroll Prize website. "But the quest to uncover the secrets of the scrolls is just beginning...." Only now, with the advent of X-ray tomography and machine learning, can their inky words be pulled from the darkness of carbon.
A few months ago students deciphered a single word — "purple," according to the article. But "That winning code was then made available for all competitors to build upon." Within three months, passages in Latin and Greek were blooming from the blackness, almost as if by magic. The team with the most readable submission at the end of 2023 included both previous finders of the word 'purple'. Their unfurling of scroll 1 is truly impressive and includes more than 11 columns of text. Experts are now rushing to translate what has been found. So far, about 5 percent of the scroll has been unrolled and read to date. It is not a duplicate of past work, scholars of the Vesuvius Challenge say, but a "never-before-seen text from antiquity."

One line reads: "In the case of food, we do not right away believe things that are scarce to be absolutely more pleasant than those which are abundant."
Thanks to davidone (Slashdot reader #12,252) for sharing the article.

High-capacity DNA data storage "is closer than you think," Slashdot wrote in 2019.

Now IEEE Spectrum brings an update on where we're at — and where we're headed — by a participant in the DNA storage collaboration between Microsoft and the Molecular Information Systems Lab of the Paul G. Allen School of Computer Science and Engineering at the University of Washington. "Organizations around the world are already taking the first steps toward building a DNA drive that can both write and read DNA data," while "funding agencies in the United States, Europe, and Asia are investing in the technology stack required to field commercially relevant devices." The challenging part is learning how to get the information into, and back out of, the molecule in an economically viable way... For a DNA drive to compete with today's archival tape drives, it must be able to write about 2 gigabits per second, which at demonstrated DNA data storage densities is about 2 billion bases per second. To put that in context, I estimate that the total global market for synthetic DNA today is no more than about 10 terabases per year, which is the equivalent of about 300,000 bases per second over a year. The entire DNA synthesis industry would need to grow by approximately 4 orders of magnitude just to compete with a single tape drive. Keeping up with the total global demand for storage would require another 8 orders of magnitude of improvement by 2030. But humans have done this kind of scaling up before. Exponential growth in silicon-based technology is how we wound up producing so much data. Similar exponential growth will be fundamental in the transition to DNA storage...

Companies like DNA Script and Molecular Assemblies are commercializing automated systems that use enzymes to synthesize DNA. These techniques are replacing traditional chemical DNA synthesis for some applications in the biotechnology industry... [I]t won't be long before we can combine the two technologies into one functional device: a semiconductor chip that converts digital signals into chemical states (for example, changes in pH), and an enzymatic system that responds to those chemical states by adding specific, individual bases to build a strand of synthetic DNA. The University of Washington and Microsoft team, collaborating with the enzymatic synthesis company Ansa Biotechnologies, recently took the first step toward this device... The path is relatively clear; building a commercially relevant DNA drive is simply a matter of time and money...

At the same time, advances in DNA synthesis for DNA storage will increase access to DNA for other uses, notably in the biotechnology industry, and will thereby expand capabilities to reprogram life. Somewhere down the road, when a DNA drive achieves a throughput of 2 gigabases per second (or 120 gigabases per minute), this box could synthesize the equivalent of about 20 complete human genomes per minute. And when humans combine our improving knowledge of how to construct a genome with access to effectively free synthetic DNA, we will enter a very different world... We'll be able to design microbes to produce chemicals and drugs, as well as plants that can fend off pests or sequester minerals from the environment, such as arsenic, carbon, or gold. At 2 gigabases per second, constructing biological countermeasures against novel pathogens will take a matter of minutes. But so too will constructing the genomes of novel pathogens. Indeed, this flow of information back and forth between the digital and the biological will mean that every security concern from the world of IT will also be introduced into the world of biology...

The future will be built not from DNA as we find it, but from DNA as we will write it.
The article makes an interesting point — that biology labs around the world already order chemically-synthesized ssDNA, "delivered in lengths of up to several hundred bases," and sequence DNA molecules up to thousands of bases in length.

"In other words, we already convert digital information to and from DNA, but generally using only sequences that make sense in terms of biology."

Japanese scientists plan to launch a satellite made of magnolia wood this summer on a U.S. rocket, reports the Observer.

Experiments carried out on the International Space Station showed magnolia wood was unusually stable and resistant to cracking — and "when it burns up as it re-enters the atmosphere after completing its mission, will produce only a fine spray of Âbiodegradable ash." The LignoSat probe has been built by researchers at Kyoto University and the logging company Sumitomo Forestry in order to test the idea of using biodegradable materials such as wood to see if they can act as environmentally friendly alternatives to the metals from which all satellites are currently constructed. "All the satellites which re-enter the Earth's atmosphere burn and create tiny alumina particles, which will float in the upper atmosphere for many years," Takao Doi a Japanese astronaut and aerospace engineer with Kyoto University, warned recently. "Eventually, it will affect the environment of the Earth."

To tackle the problem, Kyoto researchers set up a project to evaluate types of wood to determine how well they could withstand the rigours of space launch and lengthy flights in orbit round the Earth. The first tests were carried out in laboratories that recreated conditions in space, and wood samples were found to have suffered no measurable changes in mass or signs of decomposition or damage. "Wood's ability to withstand these conditions astounded us," said Koji Murata, head of the project.

After these tests, samples were sent to the ISS, where they were subjected to exposure trials for almost a year before being brought back to Earth. Again they showed little signs of damage, a phenomenon that Murata attributed to the fact that there is no oxygen in space which could cause wood to burn, and no living creatures to cause it to rot.
The article adds that if it performs well in space, "then the door could be opened for the use of wood as a construction material for more satellites."

"Would you like to live on Mars?" NASA asked Friday on social media.

"You can help us move humanity toward that goal by participating in a simulated, year-long Mars surface mission at NASA's Johnson Space Center." NASA is seeking applicants to participate in its next simulated one-year Mars surface mission to help inform the agency's plans for human exploration of the Red Planet. The second of three planned ground-based missions called CHAPEA (Crew Health and Performance Exploration Analog) is scheduled to kick off in spring 2025.

Each CHAPEA mission involves a four-person volunteer crew living and working inside a 1,700-square-foot, 3D-printed habitat based at NASA's Johnson Space Center in Houston. The habitat, called the Mars Dune Alpha, simulates the challenges of a mission on Mars, including resource limitations, equipment failures, communication delays, and other environmental stressors. Crew tasks include simulated spacewalks, robotic operations, habitat maintenance, exercise, and crop growth.

NASA is looking for healthy, motivated U.S. citizens or permanent residents who are non-smokers, 30-55 years old, and proficient in English for effective communication between crewmates and mission control. Applicants should have a strong desire for unique, rewarding adventures and interest in contributing to NASA's work to prepare for the first human journey to Mars...

As NASA works to establish a long-term presence for scientific discovery and exploration on the Moon through the Artemis campaign, CHAPEA missions provide important scientific data to validate systems and develop solutions for future missions to the Red Planet. With the first CHAPEA crew more than halfway through their yearlong mission, NASA is using research gained through the simulated missions to help inform crew health and performance support during Mars expeditions.
You can see the simulated Mars habitat in this NASA video.

The deadline for applicants is Tuesday, April 2, according to NASA. "A master's degree in a STEM field such as engineering, mathematics, or biological, physical or computer science from an accredited institution with at least two years of professional STEM experience or a minimum of one thousand hours piloting an aircraft is required."

For the first time, scientists say they've detected water molecules on the surface of an asteroid. Space.com reports: Scientists studied four silicate-rich asteroids using data gathered by the now-retired Stratospheric Observatory for Infrared Astronomy (SOFIA), a telescope-outfitted plane operated by NASA and the German Aerospace Center. Observations by SOFIA's Faint Object InfraRed Camera (FORCAST) instrument showed that two of the asteroids -- named Iris and Massalia -- exhibit a specific wavelength of light that indicated the presence of water molecules at their surface, a new study reports.

While water molecules have previously been detected in asteroid samples returned to Earth, this is the first time that water molecules have been found on the surface of an asteroid in space. In a previous study, SOFIA found similar traces of water on the surface of the moon, in one of the largest craters in its southern hemisphere. [...]

Therefore, the findings at Iris and Massalia suggest that some silicate asteroids can conserve some of their water over the eons and may be more commonly found in the inner solar system than previously thought. In fact, asteroids are believed to be the primary source of Earth's water, providing the necessary elements for life as we know it. Understanding of the distribution of water through space will help researchers better assess where to search for other forms of potential life, both in our solar system and beyond. The findings have been published in The Planetary Science Journal.

A paper (PDF) from researchers at the University of Cambridge, supported by voices from numerous academic institutions including OpenAI, proposes remote kill switches and lockouts as methods to mitigate risks associated with advanced AI technologies. It also recommends tracking AI chip sales globally. The Register reports: The paper highlights numerous ways policymakers might approach AI hardware regulation. Many of the suggestions -- including those designed to improve visibility and limit the sale of AI accelerators -- are already playing out at a national level. Last year US president Joe Biden put forward an executive order aimed at identifying companies developing large dual-use AI models as well as the infrastructure vendors capable of training them. If you're not familiar, "dual-use" refers to technologies that can serve double duty in civilian and military applications. More recently, the US Commerce Department proposed regulation that would require American cloud providers to implement more stringent "know-your-customer" policies to prevent persons or countries of concern from getting around export restrictions. This kind of visibility is valuable, researchers note, as it could help to avoid another arms race, like the one triggered by the missile gap controversy, where erroneous reports led to massive build up of ballistic missiles. While valuable, they warn that executing on these reporting requirements risks invading customer privacy and even lead to sensitive data being leaked.

Meanwhile, on the trade front, the Commerce Department has continued to step up restrictions, limiting the performance of accelerators sold to China. But, as we've previously reported, while these efforts have made it harder for countries like China to get their hands on American chips, they are far from perfect. To address these limitations, the researchers have proposed implementing a global registry for AI chip sales that would track them over the course of their lifecycle, even after they've left their country of origin. Such a registry, they suggest, could incorporate a unique identifier into each chip, which could help to combat smuggling of components.

At the more extreme end of the spectrum, researchers have suggested that kill switches could be baked into the silicon to prevent their use in malicious applications. [...] The academics are clearer elsewhere in their study, proposing that processor functionality could be switched off or dialed down by regulators remotely using digital licensing: "Specialized co-processors that sit on the chip could hold a cryptographically signed digital "certificate," and updates to the use-case policy could be delivered remotely via firmware updates. The authorization for the on-chip license could be periodically renewed by the regulator, while the chip producer could administer it. An expired or illegitimate license would cause the chip to not work, or reduce its performance." In theory, this could allow watchdogs to respond faster to abuses of sensitive technologies by cutting off access to chips remotely, but the authors warn that doing so isn't without risk. The implication being, if implemented incorrectly, that such a kill switch could become a target for cybercriminals to exploit.

Another proposal would require multiple parties to sign off on potentially risky AI training tasks before they can be deployed at scale. "Nuclear weapons use similar mechanisms called permissive action links," they wrote. For nuclear weapons, these security locks are designed to prevent one person from going rogue and launching a first strike. For AI however, the idea is that if an individual or company wanted to train a model over a certain threshold in the cloud, they'd first need to get authorization to do so. Though a potent tool, the researchers observe that this could backfire by preventing the development of desirable AI. The argument seems to be that while the use of nuclear weapons has a pretty clear-cut outcome, AI isn't always so black and white. But if this feels a little too dystopian for your tastes, the paper dedicates an entire section to reallocating AI resources for the betterment of society as a whole. The idea being that policymakers could come together to make AI compute more accessible to groups unlikely to use it for evil, a concept described as "allocation."

After a 6-1 vote by the district board, San Francisco middle schools will teach Algebra I again this fall. Axios reports: Roughly a third of SFUSD middle schools this fall will begin offering the course to eighth graders at about a third of its 13 middle schools as well as six of its K-8 schools, the San Francisco Chronicle reports. Students at other campuses will have access to the course via online classes or summer school while their schools take three years to make the transition. Those eighth graders will otherwise have to wait until high school to take the course.

District officials plan to evaluate the best way to enroll students throughout the district in a pilot at the first schools this fall. The first approach would be to enroll all eighth graders. The second would prioritize students' interest or readiness. The third would give students the option of taking Algebra I on top of current eighth-grade math curricula.

The 6-1 vote by the San Francisco Unified School District board Tuesday followed a decadelong battle over eighth graders' access to higher-level math courses and a larger debate over academic opportunity and equity in math performance. SFUSD previously taught eighth-grade algebra. But in 2014, the board voted to wait until high school to try to address racial gaps that had emerged as some students moved quicker to advanced math classes. Studies have shown that inequities including socioeconomic status, language differences and implicit bias often impede Black and Latino students' educational pursuits and result in lower rates of enrollment in higher-level classes. Yes, but: Stanford researchers found last year that large racial and ethnic gaps in advanced math enrollment persisted even after the policy change.

Jordan Pearson reports via Motherboard: A peer-reviewed science journal published a paper this week filled with nonsensical AI-generated images, which featured garbled text and a wildly incorrect diagram of a rat penis. The episode is the latest example of how generative AI is making its way into academia with concerning effects. The paper, titled "Cellular functions of spermatogonial stem cells in relation to JAK/STAT signaling pathway" was published on Wednesday in the open access Frontiers in Cell Development and Biology journal by researchers from Hong Hui Hospital and Jiaotong University in China. The paper itself is unlikely to be interesting to most people without a specific interest in the stem cells of small mammals, but the figures published with the article are another story entirely. [...]

It's unclear how this all got through the editing, peer review, and publishing process. Motherboard contacted the paper's U.S.-based reviewer, Jingbo Dai of Northwestern University, who said that it was not his responsibility to vet the obviously incorrect images. (The second reviewer is based in India.) "As a biomedical researcher, I only review the paper based on its scientific aspects. For the AI-generated figures, since the author cited Midjourney, it's the publisher's responsibility to make the decision," Dai said. "You should contact Frontiers about their policy of AI-generated figures." Frontier's policies for authors state that generative AI is allowed, but that it must be disclosed -- which the paper's authors did -- and the outputs must be checked for factual accuracy. "Specifically, the author is responsible for checking the factual accuracy of any content created by the generative AI technology," Frontier's policy states. "This includes, but is not limited to, any quotes, citations or references. Figures produced by or edited using a generative AI technology must be checked to ensure they accurately reflect the data presented in the manuscript."

On Thursday afternoon, after the article and its AI-generated figures circulated social media, Frontiers appended a notice to the paper saying that it had corrected the article and that a new version would appear later. It did not specify what exactly was corrected. UPDATE: Frontiers retracted the article and issued the following statement: "Following publication, concerns were raised regarding the nature of its AI-generated figures. The article does not meet the standards of editorial and scientific rigor for Frontiers in Cell and Development Biology; therefore, the article has been retracted. This retraction was approved by the Chief Executive Editor of Frontiers. Frontiers would like to thank the concerned readers who contacted us regarding the published article."