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Medicine

Marketing Cancer Drugs To Physicians Increases Prescribing Without Improving Mortality 33

Abstract of a paper on National Bureau of Economic Research: Physicians commonly receive marketing-related transfers from drug firms. We examine the impact of these relationships on the prescribing of physician-administered cancer drugs in Medicare. We find that prescribing of the associated drug increases 4\% in the twelve months after a payment is received, with the increase beginning sharply in the month of payment and fading out within a year. A marketing payment also leads physicians to begin treating cancer patients with lower expected mortality. While payments result in greater expenditure on cancer drugs, there are no associated improvements in patient mortality.
Mars

The Ingenuity Mars Helicopter Just Sent Its Last Message Home (livescience.com) 27

Two months ago the team behind NASA's Ingenuity Helicopter released a video reflecting on its historic explorations of Mars, flying 10.5 miles (17.0 kilometers) in 72 different flights over three years. It was the team's way of saying goodbye, according to NASA's video.

And this week, LiveScience reports, Ingenuity answered back: On April 16, Ingenuity beamed back its final signal to Earth, which included the remaining data it had stored in its memory bank and information about its final flight. Ingenuity mission scientists gathered in a control room at NASA's Jet Propulsion Laboratory (JPL) in California to celebrate and analyze the helicopter's final message, which was received via NASA's Deep Space Network, made up of ground stations located across the globe.

In addition to the remaining data files, Ingenuity sent the team a goodbye message including the names of all the people who worked on the mission. This special message had been sent to Perseverance the day before and relayed to Ingenuity to send home.

The helicopter, which still has power, will now spend the rest of its days collecting data from its final landing spot in Valinor Hills, named after a location in J.R.R. Tolkien's "The Lord of the Rings" books.

The chopper will wake up daily to test its equipment, collect a temperature reading and take a single photo of its surroundings. It will continue to do this until it loses power or fills up its remaining memory space, which could take 20 years. Such a long-term dataset could not only benefit future designs for Martian vehicles but also "provide a long-term perspective on Martian weather patterns and dust movement," researchers wrote in the statement. However, the data will be kept on board the helicopter and not beamed back to Earth, so it must be retrieved by future Martian vehicles or astronauts.

"Whenever humanity revisits Valinor Hills — either with a rover, a new aircraft, or future astronauts — Ingenuity will be waiting with her last gift of data," Teddy Tzanetos, an Ingenuity scientist at JPL, said in the statement.

Thursday NASA's Jet Propulsion Laboratory released another new video tracing the entire route of Ingenuity's expedition over the surface of Mars.

"Ingenuity's success could pave the way for more extensive aerial exploration of Mars down the road," adds Spacae.com: Mission team members are already working on designs for larger, more capable rotorcraft that could collect a variety of science data on the Red Planet, for example. And Mars isn't the only drone target: In 2028, NASA plans to launch Dragonfly, a $3.3 billion mission to Saturn's huge moon Titan, which hosts lakes, seas and rivers of liquid hydrocarbons on its frigid surface. The 1,000-pound (450 kg) Dragonfly will hop from spot to spot on Titan, characterizing the moon's various environments and assessing its habitability.
Space

Some Astronomers Will Re-Examine a 102-Year-Old Theory About the Universe's Expansion (futurism.com) 77

Several "high-profile astronomers" will meet at London's Royal Society (the UK's national academy of sciences), "to question some of the most fundamental aspects of our understanding of the universe.reports Futurism: As The Guardian reports, the luminaries of cosmology will be re-examining some basic assumptions about the universe — right down to the over-a-century-old theory that it's expanding at a constant rate. "We are, in cosmology, using a model that was first formulated in 1922," coorganizer and Oxford cosmologist Subir Sarkar told the newspaper, in an apparent reference to the year Russian astronomer Alexander Friedmann outlined the possibility of cosmic expansion based on Einstein's general theory of relativity. "We have great data, but the theoretical basis is past its sell-by date," he added. "More and more people are saying the same thing and these are respected astronomers."

A number of researchers have found evidence that the universe may be expanding more quickly in some areas compared to others, raising the tantalizing possibility that megastructures could be influencing the universe's growth in significant ways. Sarkar and his colleagues, for instance, are suggesting that the universe is "lopsided" after studying over a million quasars, which are the active nuclei of galaxies where gas and dust are being gobbled up by a supermassive black hole.

The article notes that another theory is that the so-called cosmological constant that's been used for decades "actually varies across space."

Thanks to long-time Slashdot reader schwit1 for sharing the article.
Space

JWST Gets an IMAX Documentary: 'Deep Sky' (imax.com) 16

A large-screen IMAX documentary about the James Webb Space Telescope "has just opened in 300 theaters across North America," write an anonymous Slashdot reader, noting that it's playing for one week only. "And it gets a rave review in Forbes." Imagine venturing to the beginning of time and space, exploring cosmic landscapes so vast and beautiful that they've remained unseen by human eyes until now.

This is the promise of "Deep Sky," an extraordinary IMAX presentation that brings the universe's awe-inspiring mysteries closer than ever before. Directed by the Oscar®-nominated filmmaker Nathaniel Kahn and narrated by the equally acclaimed actress Michelle Williams, "Deep Sky" is a monumental journey through the cosmos, powered by the groundbreaking images captured by NASA's Webb Telescope... "Deep Sky" is more than a documentary about a space telescope; it's an immersive experience that invites audiences to see the universe as never before. Through the power of IMAX, viewers are transported across 13 billion years of cosmic history, to the very edges of the observable universe. Here, in stunning clarity, we witness the birth of stars, the formation of galaxies, and the eerie beauty of exoplanets — planets that orbit stars beyond our own Sun. These images, beamed back to Earth by JWST, reveal the universe's vast beauty on a scale that seems only the giant IMAX screen can begin to convey...

What makes "Deep Sky" particularly captivating is its ability to render the incomprehensible beauty and scale of the universe accessible. The IMAX® experience, known for its breathtaking visuals and sound, serves as the perfect medium to convey the majesty of the cosmos.

The review says the film celebrates the achieve of thousands of people working across decades, "aiming to answer some of humanity's oldest questions: Where did we come from? How did the universe begin? Are we alone in the vastness of space?"

The reviewer also spoke to JWST telescope scientist Matt Mountain — in another article applauding the film for "encapsulating the grandeur of space exploration on the IMAX canvas." In "Deep Sky," viewers are taken on a journey from the telescope's construction to its deployment and early operational phases. The documentary highlights the international collaboration and engineering marvels behind the JWST, featuring insights from key scientists and engineers who brought the telescope to life. The film aims to rekindle a sense of wonder about the universe and our place within it, emphasizing the human desire to explore and understand the cosmos.
Space

NASA Veteran Behind Propellantless Propulsion Drive Announces Major Discovery (thedebrief.org) 259

Longtime Slashdot reader garyisabusyguy shares a report from The Debrief: Dr. Charles Buhler, a NASA engineer and the co-founder of Exodus Propulsion Technologies, has revealed that his company's propellantless propulsion drive, which appears to defy the known laws of physics, has produced enough thrust to counteract Earth's gravity. "The most important message to convey to the public is that a major discovery occurred," Buhler told The Debrief. "This discovery of a New Force is fundamental in that electric fields alone can generate a sustainable force onto an object and allow center-of-mass translation of said object without expelling mass." "There are rules that include conservation of energy, but if done correctly, one can generate forces unlike anything humankind has done before," Buhler added. "It will be this force that we will use to propel objects for the next 1,000 years until the next thing comes."

To document his team's discovery as well as the process behind their work, which Dr. Buhler cautions is in no way affiliated with NASA or the U.S. Government, the outwardly amiable researcher presented his findings at a recent Alternative Propulsion Energy Conference (APEC). Filled with both highly-credentialed career engineers and propulsion hobbyists, APEC is an organization The Debrief once referred to as the World's Most Exclusive (And Strange) Anti-Gravity Club. In conjunction with that presentation, "The Discovery of Propellantless Propulsion: The Direct Conversion of Electrical Energy into Physical Thrust," Dr. Buhler also sat down with APEC co-founder and moderator Tim Ventura to explain how his past in electrostatics, which is his primary area of expertise, ended up being a key component of his discovery of this new force. [...]

Up next, Buhler says his team is seeking funding to test their devices in space to better understand the force at work. "We're hoping to do some demos," said Buhler. "Some space demos. That's what we're trying to get some funding to do. I think that would be a great way to show off the technology." Besides proving once and for all that the force they are seeing is real, the accomplished engineer believes that such tests could encourage other scientists to search for an explanation of what exactly it is they are seeing. "I think it's a good opportunity for people to run these tests, look at them, watch them go in space, watch it move in space, and then say, "what does it imply? What are the implications?'" Until that time, Buhler says he believes his work proves that the force they are seeing is "fundamental" and that understanding it is the next logical step. "You can't deny this," he told Ventura. "There's not a lot to this. You're just charging up Teflon, copper tape, and foam, and you have this thrust."

So, while his team believes their experiments speak for themselves, the veteran scientist says he also believes it is the job of science to analyze and understand this discovery. If successful, he thinks it may even address some of the harder questions in science, including the nature of dark energy or even space/time itself. "It's easy to make these things," he said, "so it's a tool for the scientific community to use to try to explore those hard questions."
If there are companies or individuals interested in working with Exodus Propulsion Technologies, Buhler asks that they reach out via their LinkedIn page.
Math

A Chess Formula Is Taking Over the World (theatlantic.com) 28

An anonymous reader quotes a report from The Atlantic: In October 2003, Mark Zuckerberg created his first viral site: not Facebook, but FaceMash. Then a college freshman, he hacked into Harvard's online dorm directories, gathered a massive collection of students' headshots, and used them to create a website on which Harvard students could rate classmates by their attractiveness, literally and figuratively head-to-head. The site, a mean-spirited prank recounted in the opening scene of The Social Network, got so much traction so quickly that Harvard shut down his internet access within hours. The math that powered FaceMash -- and, by extension, set Zuckerberg on the path to building the world's dominant social-media empire -- was reportedly, of all things, a formula for ranking chess players: the Elo system.

Fundamentally, what an Elo rating does is predict the outcome of chess matches by assigning every player a number that fluctuates based purely on performance. If you beat a slightly higher-ranked player, your rating goes up a little, but if you beat a much higher-ranked player, your rating goes up a lot (and theirs, conversely, goes down a lot). The higher the rating, the more matches you should win. That is what Elo was designed for, at least. FaceMash and Zuckerberg aside, people have deployed Elo ratings for many sports -- soccer, football, basketball -- and for domains as varied as dating, finance, and primatology. If something can be turned into a competition, it has probably been Elo-ed. Somehow, a simple chess algorithm has become an all-purpose tool for rating everything. In other words, when it comes to the preferred way to rate things, Elo ratings have the highest Elo rating. [...]

Elo ratings don't inherently have anything to do with chess. They're based on a simple mathematical formula that works just as well for any one-on-one, zero-sum competition -- which is to say, pretty much all sports. In 1997, a statistician named Bob Runyan adapted the formula to rank national soccer teams -- a project so successful that FIFA eventually adopted an Elo system for its official rankings. Not long after, the statistician Jeff Sagarin applied Elo to rank NFL teams outside their official league standings. Things really took off when the new ESPN-owned version of Nate Silver's 538 launched in 2014 and began making Elo ratings for many different sports. Some sports proved trickier than others. NBA basketball in particular exposed some of the system's shortcomings, Neil Paine, a stats-focused sportswriter who used to work at 538, told me. It consistently underrated heavyweight teams, for example, in large part because it struggled to account for the meaninglessness of much of the regular season and the fact that either team might not be trying all that hard to win a given game. The system assumed uniform motivation across every team and every game. Pretty much anything, it turns out, can be framed as a one-on-one, zero-sum game.
Arpad Emmerich Elo, creator of the Elo rating system, understood the limitations of his invention. "It is a measuring tool, not a device of reward or punishment," he once remarked. "It is a means to compare performances, assess relative strength, not a carrot waved before a rabbit, or a piece of candy given to a child for good behavior."
Canada

Canadian Science Gets Biggest Boost To PhD and Postdoc Pay in 20 Years (nature.com) 23

Researchers in Canada got most of what they were hoping for in the country's 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure. From a report: "We are investing over $5 billion in Canadian brainpower," said finance minister Chrystia Freeland in her budget speech on 16 April. "More funding for research and scholarships will help Canada attract the next generation of game-changing thinkers."

Postgraduate students and postdoctoral researchers have been advocating for higher pay for the past two years through a campaign called Support Our Science. They requested an increase in the value, and number, of federal government scholarships, and got more than they asked for. Stipends for master's students will rise from Can$17,500 (US$12,700) to $27,000 per year, PhDs stipends that ranged from $20,000 to $35,000 will be set to a uniform annual $40,000 and most postdoctoral-fellowship salaries will increase from $45,000 to $70,000 per annum. The number of scholarships and fellowships provided will also rise over time, building to around 1,720 more per year after five years.

"We're very thrilled with this significant new investment, the largest investment in graduate students and postdocs in over 21 years," says Kaitlin Kharas, a PhD student at the University of Toronto, Canada, and executive director of Support Our Science. "It will directly support the next generation of researchers." Although only a small proportion of students and postdoctoral fellows receive these federal scholarships, other funders tend to use them as a guide for their own stipends. Many postgraduates said that low pay was forcing them to consider leaving Canada to pursue their scientific career, says Kharas, so this funding should help to retain talent in the country.

NASA

Sweden Becomes 38th Country To Sign NASA's Artemis Accords For Moon Exploration (space.com) 14

Sweden is the newest nation to sign onto NASA's Artemis Accords -- a series of non-binding bilateral arrangements for peaceful and responsible exploration. Space.com reports: During a signing event in Stockholm on Tuesday (April 16), Swedish Minister for Education Mats Persson penned the agreement alongside U.S. Ambassador Erik D. Ramanathan. "By joining the Artemis Accords, Sweden strengthens its strategic space partnership with the U.S. on space covering areas such as Swedish space research and the space industry, which in turn also strengthens Sweden's total defense capability," Persson said in a NASA statement. The event in Stockholm comes just on the heels of Switzerland's signing of the Artemis Accords the day before. Greece and Uruguay were also included in February. Sweden is now the 38th nation to join the accords, which were established in 2020, as the first Artemis moon launch inched closer to reality.

The Accords mirror principles set out in 1967, as part of the Outer Space Treaty to help govern international cooperation space. NASA is using the refreshed agreement as a guideline for the Artemis program, which aims to send astronauts back to the moon for the first time since Apollo 17, in 1972. In the agency's statement, NASA administrator Bill Nelson welcomed Sweden to the expanding space club. "Our nations have worked together to discover new secrets in our solar system, and now, we welcome you to a global coalition that is committed to exploring the heavens openly, transparently, responsibly, and in peace," Nelson said, adding, "the United States and Sweden share the same bedrock principles, and we're excited to expand these principles to the cosmos."

Earth

Average World Incomes To Drop By Nearly a Fifth By 2050, Study Says (theguardian.com) 123

Average incomes will fall by almost a fifth within the next 26 years as a result of the climate crisis, according to a study that predicts the costs of damage will be six times higher than the price of limiting global heating to 2C. From a report: Rising temperatures, heavier rainfall and more frequent and intense extreme weather are projected to cause $38tn of destruction each year by mid-century, according to the research, which is the most comprehensive analysis of its type ever undertaken, and whose findings are published in the journal Nature. The hefty toll -- which is far higher than previous estimates -- is already locked into the world economy over the coming decades as a result of the enormous emissions that have been pumped into the atmosphere through the burning of gas, oil, coal and trees.

This will inflict crippling losses on almost every country, with a disproportionately severe impact on those least responsible for climate disruption, further worsening inequality. The paper says the permanent average loss of income worldwide will be 19% by 2049. In the United States and Europe the reduction will be about 11%, while in Africa and south Asia it will be 22%, with some individual countries much higher than this. "It's devastating," said Leonie Wenz, a scientist at the Potsdam Institute for Climate Impact Research and one of the authors of the study. "I am used to my work not having a nice societal outcome, but I was surprised by how big the damages were. The inequality dimension was really shocking."

NASA

NASA Confirms That Debris From ISS Crashed Into Florida Home (nbcnews.com) 57

NASA has confirmed that a piece of metal that tore through a Florida home last month was space junk from the International Space Station. NBC News reports: The agency confirmed Monday that the 1.6-pound object was debris from a cargo pallet that had been intentionally released from the space station three years ago. The pallet, packed with aging batteries, was supposed to burn up harmlessly in Earth's atmosphere, but a piece survived -- the piece that smashed into a house in Naples, Florida, on March 8.

WINK News, a CBS News affiliate in southwestern Florida, first reported the incident. Naples resident Alejandro Otero told the outlet that the object crashed through the roof and two floors of his home. Otero was not home at the time, he told WINK News, but the metal object nearly hit his son, who was two rooms away. In a blog post about the incident, NASA said it had analyzed the object at the Kennedy Space Center in Florida and confirmed that it was part of the equipment used to mount the batteries on the cargo pallet.

The piece of space junk is roughly cylindrical in shape and is about 4-inches tall and 1.6-inches wide. NASA said agency staff studied the object's features and metal composition and matched it to the hardware that had been jettisoned from the space station in 2021. At that time, new lithium-ion batteries had recently been installed at the space station, so the old nickel hydrogen batteries were packed up for disposal. The space station's robotic arm released the 5,800-pound cargo pallet containing the batteries over the Pacific Ocean, as the outpost orbited 260 miles above the Earth's surface, according to NASA. NASA said it will perform a detailed investigation of the latest debris incident to determine how the object withstood the extreme trip through the atmosphere.

Mars

NASA Says New Plan Needed To Return Rocks From Mars; Current Mission Design Can't Deliver Before 2040 (bbc.com) 65

SonicSpike shares a report: The quest to return rock materials from Mars to Earth to see if they contain traces of past life is going to go through a major overhaul. The US space agency says the current mission design can't return the samples before 2040 on the existing funds and the more realistic $11bn needed to make it happen is not sustainable. Nasa is going to canvas for cheaper, faster "out of the box" ideas. It hopes to have a solution on the drawing board later in the year.

Returning rock samples from Mars is regarded as the single most important priority in planetary exploration, and has been for decades. Just as the Moon rocks brought home by Apollo astronauts revolutionised our understanding of early Solar System history, so materials from the Red Planet are likely to recast our thinking on the possibilities for life beyond Earth.

NASA

CNN Reporter 'Still Haunted' By Space Shuttle Columbia Disaster (cnn.com) 94

After nearly 11 years as CNN's space correspondent, Miles O'Brien found himself in 2003 at the Kennedy Space Center in Florida covering the launch of the space shuttle Columbia: As part of the post-launch routine, NASA began sharing several replays of the launch from various cameras trained on the vehicle. And that was when we saw it. Producer Dave Santucci called me into our live truck, and said, "You got to look at this." It was kind of a grainy image of what looked like a puff of smoke, as if someone dropped a bag of flour on the ground and it broke open. We played it over and over again, and it did not look good at all. The giant orange fuel tank was filled with super cold liquid hydrogen and oxygen, so it was enveloped in insulating foam. A big piece of the foam had broken away near a strut called the "bipod," striking the leading edge of the orbiter's left wing. It was made of reinforced carbon to protect the aluminum structure of the spacecraft from the searing heat of re-entry from space.

I reached out to some of my sources inside the shuttle program. Everyone had seen it, of course, but the people I spoke with cautioned me not to worry. The foam was very light, and it had fallen off on earlier missions and nothing of concern had happened as a result... I wish I hadn't taken my eye off the ball. Space was my beat, and I was uniquely positioned to put this concerning event into the public domain. Like NASA's leadership, I went through a process of convincing myself that it was going to be okay. But I had this sinking feeling. It didn't feel right. A spacecraft re-entering the atmosphere at 17,500 miles an hour — much faster than a rifle bullet — is enveloped in a glowing inferno of plasma...

[As it returned to earth 16 days later] the communication between the ground and the orbiter became non-routine. Producers in the control room realized the gravity of the situation, and we cut to a commercial break to get me off the couch. As I was making my way across the newsroom, I started heaving. I knew in an instant that they were all gone. There was no survivable scenario. I was sickened. It was like a body blow. Somehow I got my act together and started talking. I felt like it was my responsibility to mention the foam strike, to get the information out there to the public. About an hour after Columbia had disintegrated, I shared with a huge global audience what I knew... "That bipod is the place where they think a little piece of foam fell off and hit the leading edge of that wing."

During the mission, I could have easily done a story about the foam strike, spreading the word that some NASA engineers believed there may be some reason for concern. What if I had done that? It might have made a difference.

"A rescue mission would not have been impossible," the article concludes, "and I feel certain that if NASA managers saw that gaping hole in Columbia's wing, they would've tried.

"We will never know for sure, but I do know how so many of us on the ground failed to do our jobs during that mission. It still haunts me."


CNN broadcasts the last two episodes of its four-part series Space Shuttle Columbia: The Final Flight tonight at 9 p.m. EST (time-delayed on the west coast until 9 p.m.PST). CNN's web site offers a "preview" of its live TV offerings here.

The news episodes (along with past episodes) will also be available on-demand starting Monday — "for pay TV subscribers via CNN.com, CNN connected TV and mobile apps." It's also available for purchase on Amazon Prime.

AI

AI Could Explain Why We're Not Meeting Any Aliens, Wild Study Proposes (sciencealert.com) 315

An anonymous reader shared this report from ScienceAlert: The Fermi Paradox is the discrepancy between the apparent high likelihood of advanced civilizations existing and the total lack of evidence that they do exist. Many solutions have been proposed for why the discrepancy exists. One of the ideas is the 'Great Filter.' The Great Filter is a hypothesized event or situation that prevents intelligent life from becoming interplanetary and interstellar and even leads to its demise....

[H]ow about the rapid development of AI?

A new paper in Acta Astronautica explores the idea that Artificial Intelligence becomes Artificial Super Intelligence (ASI) and that ASI is the Great Filter. The paper's title is "Is Artificial Intelligence the Great Filter that makes advanced technical civilizations rare in the universe?"

"Upon reaching a technological singularity, ASI systems will quickly surpass biological intelligence and evolve at a pace that completely outstrips traditional oversight mechanisms, leading to unforeseen and unintended consequences that are unlikely to be aligned with biological interests or ethics," the paper explains... The author says their projects "underscore the critical need to quickly establish regulatory frameworks for AI development on Earth and the advancement of a multiplanetary society to mitigate against such existential threats."

"The persistence of intelligent and conscious life in the universe could hinge on the timely and effective implementation of such international regulatory measures and
Power

Fusion Experiment Demonstrates Cheaper Stellerator Using Creative Magnet Workaround (pppl.gov) 41

Popular Science reports that early last week, researchers at the U.S. Energy Department's Princeton Plasma Physics Laboratory revealed their new "MUSE" stellarator — "a unique fusion reactor that uses off-the-shelf and 3D-printed materials to contain its superheated plasma."

The researchers' announcement says the technique suggests "a simple way to build future devices for less cost and allow researchers to test new concepts for future fusion power plants." Stellarators typically rely on complicated electromagnets that have complex shapes and create their magnetic fields through the flow of electricity. Those electromagnets must be built precisely with very little room for error, increasing their cost. However, permanent magnets, like the magnets that hold art to refrigerator doors, do not need electric currents to create their fields. They can also be ordered off the shelf from industrial suppliers and then embedded in a 3D-printed shell around the device's vacuum vessel, which holds the plasma.

"MUSE is largely constructed with commercially available parts," said Michael Zarnstorff, a senior research physicist at PPPL. "By working with 3D-printing companies and magnet suppliers, we can shop around and buy the precision we need instead of making it ourselves." The original insight that permanent magnets could be the foundation for a new, more affordable stellarator variety came to Zarnstorff in 2014. "I realized that even if they were situated alongside other magnets, rare-earth permanent magnets could generate and maintain the magnetic fields necessary to confine the plasma so fusion reactions can occur," Zarnstorff said, "and that's the property that makes this technique work." [...]

In addition to being an engineering breakthrough, MUSE also exhibits a theoretical property known as quasisymmetry to a higher degree than any other stellarator has before. It is also the first device completed anywhere in the world that was designed specifically to have a type of quasisymmetry known as quasiaxisymmetry. Conceived by physicist Allen Boozer at PPPL in the early 1980s, quasisymmetry means that although the shape of the magnetic field inside the stellarator may not be the same around the physical shape of the stellarator, the magnetic field's strength is uniform around the device, leading to good plasma confinement and higher likelihood that fusion reactions will occur. "In fact, MUSE's quasisymmetry optimization is at least 100 times better than any existing stellarator," Zarnstorff said.

"The fact that we were able to design and build this stellarator is a real achievement," said Tony Qian, a graduate student in the Princeton Program in Plasma Physics, which is based at PPPL.

Also covered by Gizmodo. Thanks to Slashdot reader christoban for sharing the news.
Math

73-Year-Old Clifford Stoll Is Now Selling Klein Bottles (berkeley.edu) 47

O'Reilly's "Tech Trends" newsletter included an interesting item this month: Want your own Klein Bottle? Made by Cliff Stoll, author of the cybersecurity classic The Cuckoo's Egg, who will autograph your bottle for you (and may include other surprises).
First described in 1882 by the mathematician Felix Klein, a Klein bottle (like a Mobius strip) has a one-side surface. ("Need a zero-volume bottle...?" asks Stoll's web site. "Want the ultimate in non-orientability...? A mathematician's delight, handcrafted in glass.")

But how the legendary cyberbreach detective started the company is explained in this 2016 article from a U.C. Berkeley alumni magazine. Its headline? "How a Berkeley Eccentric Beat the Russians — and Then Made Useless, Wondrous Objects." The reward for his cloak-and-dagger wizardry? A certificate of appreciation from the CIA, which is stashed somewhere in his attic... Stoll published a best-selling book, The Cuckoo's Egg, about his investigation. PBS followed it with a NOVA episode entitled "The KGB, the Computer, and Me," a docudrama starring Stoll playing himself and stepping through the "fourth wall" to double as narrator. Stoll had stepped through another wall, as well, into the numinous realm of fame, as the burgeoning tech world went wild with adulation... He was more famous than he ever could have dreamed, and he hated it. "After a few months, you realize how thin fame is, and how shallow. I'm not a software jockey; I'm an astronomer. But all people cared about was my computing."

Stoll's disenchantment also arose from what he perceived as the false religion of the Internet... Stoll articulated his disenchantment in his next book, Silicon Snake Oil, published in 1995, which urged readers to get out from behind their computer screens and get a life. "I was asking what I thought were reasonable questions: Is the electronic classroom an improvement? Does a computer help a student learn? Yes, but what it teaches you is to go to the computer whenever you have a question, rather than relying on yourself. Suppose I was an evil person and wanted to eliminate the curiosity of children. Give the kid a diet of Google, and pretty soon the child learns that every question he has is answered instantly. The coolest thing about being human is to learn, but you don't learn things by looking it up; you learn by figuring it out." It was not a popular message in the rise of the dot-com era, as Stoll soon learned...

Being a Voice in the Wilderness doesn't pay well, however, and by this time Stoll had taken his own advice and gotten a life; namely, marrying and having two children. So he looked around for a way to make some money. That ushered in his third — and current — career as President and Chief Bottle Washer of the aforementioned Acme Klein Bottle company... At first, Stoll had a hard time finding someone to make Klein bottles. He tried a bong peddler on Telegraph Avenue, but the guy took Cliff's money and disappeared. "I realized that the trouble with bong makers is that they're also bong users."

Then in 1994, two friends of his, Tom Adams and George Chittenden, opened a shop in West Berkeley that made glassware for science labs. "They needed help with their computer program and wanted to pay me," Stoll recalls. "I said, 'Nah, let's make Klein bottles instead.' And that's how Acme Klein Bottles was born."

UPDATE: Turns out Stoll is also a long-time Slashdot reader, and shared comments this weekend on everything from watching the eclipse to his VIP parking pass for CIA headquarters and "this CIA guy's rubber-stamp collection."

"I am honored by the attention and kindness of fellow nerds and online friends," Stoll added Saturday. "When I first started on that chase in 1986, I had no idea wrhere it would lead me... To all my friends: May you burdens be light and your purpose high. Stay curious!"
Japan

Japanese Astronauts To Land On Moon As Part of New NASA Partnership (spacenews.com) 17

Under a new agreement between the U.S. and Japan, the first non-American on the Moon as part of the Artemis lunar exploration campaign will be a Japanese astronaut. SpaceNews reports: At an event in Washington, NASA Administrator Bill Nelson and Japanese Minister of Education, Culture, Sports, Science and Technology (MEXT) Masahito Moriyama signed an agreement regarding an additional Japanese contribution to Artemis, a pressurized lunar rover called Lunar Cruiser. NASA will deliver the rover to the moon, which the agencies said should take place ahead of the Artemis 7 mission scheduled for no earlier than 2031. NASA will also provide two seats on future Artemis lunar landing missions to astronauts from the Japanese space agency JAXA, the first agency other than NASA to secure spots on landing missions.

The Japanese rover will support extended expeditions from Artemis landing sites that are beyond the range of the Lunar Terrain Vehicle that three American companies are developing for NASA under contracts announced April 3. The rover is designed to accommodate two astronauts for up to 30 days, with an overall lifetime of 10 years. The announcement, though, offered no details about when the Japanese astronauts would fly to the moon. "It depends," Nelson said at an April 10 briefing when asked about schedules, noting that the two countries "announced a shared goal for a Japanese national to land on the moon on a future NASA mission assuming benchmarks are achieved."

"No mission has been currently assigned to a Japanese astronaut," added Lara Kearney, manager of NASA's extravehicular activity and human surface mobility program, at the briefing. The implementing agreement (PDF) said several factors will go into crew assignments, including progress on the pressurized rover, or PR: "The timing of the flight opportunities will be determined by NASA in line with existing flight manifesting and crew assignment processes and will take into account program progress and constraints, MEXT's request for the earliest possible assignment of the Japanese astronauts to lunar surface missions, and major PR milestones such as when the PR is first deployed on the lunar surface." The assumption among many in the industry, though, is that at least one of the astronauts will fly before the rover is delivered, and possibly as soon as the Artemis 4 mission, the second crewed landing, in the late 2020s.

Space

ESA Prepares To Create Solar Eclipses To Study the Sun (ieee.org) 19

Andrew Jones reports via IEEE Spectrum: The European Space Agency will launch a mission late this year to demonstrate precision formation flying in orbit to create artificial solar eclipses. In a press conference last week, the agency announced details of the mission and the technology the orbiters will use to pull off its exquisitely-choreographed maneuvers. ESA's Proba-3 (PRoject for On-Board Autonomy) consists of a pair of spacecraft: a 300-kilogram Coronagraph spacecraft and a 250-kilogram Occulter. The pair are now slated to launch on an Indian PSLV rocket in September and ultimately enter a highly elliptical, 600-by-60,530-kilometer orbit. The aim, the agency says, is to move the separate spacecraft to some 144 meters apart, with the Occulter, as a disc, blocking out the sun.

Achieving this formation will allow the Coronagraph to study our star's highly ionized, extremely hot atmosphere -- but also demonstrate the technology as a precursor for more ambitious, future, formation-flying endeavors. [...] ESA has science objectives for Proba-3, using observations made in space to study solar astrophysics without any intervention of the Earth's atmosphere. The agency's Association of Spacecraft for Polarimetric and Imaging Investigation of the Corona of the Sun (ASPIICS) coronagraph will help to discern why the solar corona is significantly hotter than the Sun itself. This could further our understanding of the Sun and assist solar weather predictions. However, it is the precision formation flying that Proba-3 aims to demonstrate which could help unlock future breakthroughs. [...]

Precisely-controlled Occulter spacecraft could be used with space telescopes to block light from a star in order to directly detect potential orbiting planets, while a constellation of spacecraft can, through interferometry, create large-scale observatories, achieving large apertures and long focal lengths than possible with large solo satellites. Further applications include Earth observation, space-based gravitational wave detection, and a range of missions in which two or more spacecraft need to interact, such as rendezvous, docking, and in-orbit servicing.

Science

Scientists Discover First Nitrogen-Fixing Organelle (phys.org) 25

In two recent papers, an international team of scientists describes the first known nitrogen-fixing organelle within a eukaryotic cell, which the researchers are calling a nitroplast. Phys.Org reports: The discovery of the organelle involved a bit of luck and decades of work. In 1998, Jonathan Zehr, a UC Santa Cruz distinguished professor of marine sciences, found a short DNA sequence of what appeared to be from an unknown nitrogen-fixing cyanobacterium in Pacific Ocean seawater. Zehr and colleagues spent years studying the mystery organism, which they called UCYN-A. At the same time, Kyoko Hagino, a paleontologist at Kochi University in Japan, was painstakingly trying to culture a marine alga. It turned out to be the host organism for UCYN-A. It took her over 300 sampling expeditions and more than a decade, but Hagino eventually successfully grew the alga in culture, allowing other researchers to begin studying UCYN-A and its marine alga host together in the lab. For years, the scientists considered UCYN-A an endosymbiont that was closely associated with an alga. But the two recent papers suggest that UCYN-A has co-evolved with its host past symbiosis and now fits criteria for an organelle.

In a paper published in Cell in March 2024, Zehr and colleagues from the Massachusetts Institute of Technology, Institut de Ciencies del Mar in Barcelona and the University of Rhode Island show that the size ratio between UCYN-A and their algal hosts is similar across different species of the marine haptophyte algae Braarudosphaera bigelowii. The researchers use a model to demonstrate that the growth of the host cell and UCYN-A are controlled by the exchange of nutrients. Their metabolisms are linked. This synchronization in growth rates led the researchers to call UCYN-A "organelle-like." "That's exactly what happens with organelles," said Zehr. "If you look at the mitochondria and the chloroplast, it's the same thing: they scale with the cell."

But the scientists did not confidently call UCYN-A an organelle until confirming other lines of evidence. In the cover article of the journal Science, published today, Zehr, Coale, Kendra Turk-Kubo and Wing Kwan Esther Mak from UC Santa Cruz, and collaborators from the University of California, San Francisco, the Lawrence Berkeley National Laboratory, National Taiwan Ocean University, and Kochi University in Japan show that UCYN-A imports proteins from its host cells. "That's one of the hallmarks of something moving from an endosymbiont to an organelle," said Zehr. "They start throwing away pieces of DNA, and their genomes get smaller and smaller, and they start depending on the mother cell for those gene products -- or the protein itself -- to be transported into the cell."

Coale worked on the proteomics for the study. He compared the proteins found within isolated UCYN-A with those found in the entire algal host cell. He found that the host cell makes proteins and labels them with a specific amino acid sequence, which tells the cell to send them to the nitroplast. The nitroplast then imports the proteins and uses them. Coale identified the function of some of the proteins, and they fill gaps in certain pathways within UCYN-A. "It's kind of like this magical jigsaw puzzle that actually fits together and works," said Zehr. In the same paper, researchers from UCSF show that UCYN-A replicates in synchrony with the alga cell and is inherited like other organelles.

China

China Moving At 'Breathtaking Speed' In Final Frontier, Space Force Says (space.com) 196

China is rapidly advancing its space capabilities to challenge the United States' dominance in space, as evidenced by its significant increase in on-orbit intelligence and reconnaissance satellites and the development of sophisticated counterspace weapons. Space.com reports: "Frankly, China is moving at a breathtaking speed. Since 2018, China has more than tripled their on-orbit intelligence, surveillance and reconnaissance satellites," Gen. Stephen Whiting, commander of U.S. Space Command, said here on Tuesday, during a talk at the 39th Space Symposium. "And with these systems, they've built a kill web over the Pacific Ocean to find, fix, track and, yes, target United States and allied military capabilities," he added. And that's not all. China has also "built a range of counterspace weapons, from reversible jamming all the way up to kinetic hit-to-kill direct-ascent and co-orbital ASATs," Whiting said.

Indeed, China demonstrated direct-ascent ASAT, or anti-satellite, weapon technology back in January 2007, when it destroyed one of its defunct weather satellites with a missile. That test was widely decried as irresponsible, for it generated thousands of pieces of debris, many of which are still cluttering up Earth orbit. Such activities show that China is now treating space as a war-fighting domain, Whiting said. And so, he added, is Russia, which has also conducted ASAT tests recently, including a destructive one in November 2021. Russia has also been aggressively building out its orbital architecture; since 2018, the nation has more than doubled its total number of active satellites, according to Whiting. The U.S. government has taken notice of these trends.

"We are at a pivotal moment in history," Troy Meink, principal deputy director of the National Reconnaissance Office, which builds and operates the United States' fleet of spy satellites, said during a different talk on Tuesday here at the symposium. "For the first time in decades, U.S. leadership in space and space technology is being challenged," Meink added. "Our competitors are actively seeking ways to threaten our capabilities, and we see this every day." The U.S. must act if it wishes to beat back this challenge, Meink and Whiting stressed; it cannot rely on the inertia of past success to do the job. For example, Meink highlighted the need to innovate with the nation's reconnaissance satellites, to make them more numerous, more agile and more resilient. U.S. Under Secretary of Defense for Research and Engineering Heidi Shyu also emphasized the importance of increasing resilience, a goal that she said could be achieved by diversifying the nation's space capabilities. "We must assess ways to incorporate radiation-hardened electronics, novel orbits, varied communication pathways, advancements in propulsion technologies and increased cooperation with our allies," Shyu said in another talk on Tuesday at the symposium.

Science

Computer Scientist Wins Turing Award for Seminal Work on Randomness (arstechnica.com) 31

Computational scientist and mathematician Avi Wigderson of the Institute for Advanced Study (IAS) in Princeton has won the 2023 A.M. Turing Award. From a report: The prize, which is given annually by the Association for Computing Machinery (ACM) to a computer scientist for their contributions to the field, comes with $1 million thanks to Google. It is named in honor of the British mathematician Alan Turing, who helped develop a theoretical foundation for understanding machine computation. Wigderson is being honored "for foundational contributions to the theory of computation, including reshaping our understanding of the role of randomness in computation and for his decades of intellectual leadership in theoretical computer science." He also won the prestigious Abel Prize in 2021 for his work in theoretical computer science -- the first person to be so doubly honored.

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