An anonymous reader quotes a report from the BBC: US scientists have, for the first time, made early-stage human embryos by manipulating DNA taken from people's skin cells and then fertilizing it with sperm. The technique could overcome infertility due to old age or disease, by using almost any cell in the body as the starting point for life. It could even allow same-sex couples to have a genetically related child. [...]

The Oregon Health and Science University research team's technique takes the nucleus -- which houses a copy of the entire genetic code needed to build the body -- out of a skin cell. This is then placed inside a donor egg that has been stripped of its genetic instructions. So far, the technique is like the one used to create Dolly the Sheep -- the world's first cloned mammal -- born back in 1996. However, this egg is not ready to be fertilized by sperm as it already contains a full suite of chromosomes.

You inherit 23 of these bundles of DNA from each of your parents for a total of 46, which the egg already has. So the next stage is to persuade the egg to discard half of its chromosomes in a process the researchers have termed "mitomeiosis" (the word is a fusion of mitosis and meiosis, the two ways cells divide). The study, published in the journal Nature Communications, showed 82 functional eggs were made. These were fertilized with sperm and some progressed onto the early stages of embryos development. None were developed beyond the six-day-stage.

The technique is far from polished as the egg randomly chooses which chromosomes to discard. It needs to end up with one of each of the 23 types to prevent disease, but ends up with two of some and none of others. There is also a poor success rate (around 9%) and the chromosomes miss an important process where they rearrange their DNA, called crossing over. Prof Mitalipov, a world-renowned pioneer in the field, told me: "We have to perfect it. "Eventually, I think that's where the future will go because there are more and more patients that cannot have children."

Cancer rates among people aged 15 to 49 have increased 10% since 2000 even as rates have fallen among older populations. Young women face an 83% higher cancer rate than men in the same age range. A 150,000-person study presented at the American Association for Cancer Research meeting found millennials appear to be aging biologically faster than previous generations based on blood biomarkers. That acceleration was associated with up to 42% increased risk for certain cancers including lung, gastrointestinal and uterine malignancies.

Researchers are examining the "exposome" -- the full range of environmental exposures across a person's life. Studies have linked early-onset cancers to medications taken during pregnancy, ultra-processed foods that now account for more than half of daily calorie intake in the United States, circadian rhythm disruption from artificial light and shift work, and chemical exposures. Gary Patti at Washington University is using zebrafish exposed to known and suspected carcinogens to track tumor development. His lab has developed systems to scan blood samples for tens of thousands of chemicals simultaneously to identify signatures appearing more frequently in early-onset cancer patients.

BrianFagioli shares a report from NERDS.xyz: NASA has awarded Solstar Space a $150,000 SBIR Phase I contract to develop a Lunar Wi-Fi Access Point (LWIFI-AP). The system is designed to provide wireless connectivity for astronauts, rovers, and orbiting spacecraft as part of the Artemis and Commercial Lunar Payload Services programs. Solstar's goal is to build a space-rated, multi-band, multi-protocol access point that can survive radiation, extreme lunar temperatures, and other harsh conditions. NASA has identified Wi-Fi and 3GPP standards as core communication needs across mission systems ranging from the Human Landing System and Lunar Terrain Vehicle to the Lunar Gateway.

Although this is only an early-stage contract, Solstar's proposal addresses a clear gap in space-qualified networking hardware. The company says that just as Wi-Fi transformed daily life on Earth, it will be equally important for living and working on the Moon. If the project advances, astronauts could soon be relying on familiar wireless technology that has been adapted for one of the most challenging environments in existence.

Sen. Mark Kelly and three Democratic colleagues urged appropriations leaders to block funding for moving space shuttle Discovery from the Smithsonian's Udvar-Hazy Center in Virginia to Houston, arguing the transfer would waste taxpayer money, risk permanent damage, and restrict public access. The relocation, pushed by Texas senators Cornyn and Cruz under a new law, carries an estimated cost of nearly $400 million. Ars Technica reports: "Why should hundreds of millions of taxpayer dollars be spent just to jeopardize a piece of American history that's already protected and on display?" wrote Kelly in a social media post on Friday. "Space Shuttle Discovery belongs at the Smithsonian, where millions of people, including students and veterans, go to see it for free." In a letter sent on the same day to the leadership of the Senate Committee on Appropriations, Kelly and his three colleagues cautioned that any effort to transfer the winged orbiter would "waste taxpayer dollars, risk permanent damage to the shuttle, and mean fewer visitors would be able to visit it." "It is worth noting that there is little evidence of broad public demand for such a move," wrote Kelly, Warner, Kaine, and Durbin.

In the letter, the senators asked that committee chair Susan Collins (R-Maine) and vice chair Patty Murray (D-Wash.) block funding for Discovery's relocation in both the fiscal year 2026 Interior-Environment appropriations bill and FY26 Commerce, Justice, Science appropriations bill. [...] "Houston's disappointment in not being selected is wholly understandable," the four senators wrote, "but removing an item from the National Collection is not a viable solution." [...] "There are also profound financial challenges associated with this transfer," wrote Kelly. Warner, Kaine, and Durbin. "The Smithsonian estimates that transporting Discovery from Virginia to Houston could cost more than $50 million, with another $325 million needed for planning, exhibit reconstruction, and new facilities." "Dedicating hundreds of millions of taxpayer dollars to move an artifact that is already housed, displayed, and preserved in a world-class facility is both inefficient and unjustifiable," the senators wrote.

Then there are the logistical challenges with relocating Discovery, which could result in damaging it, "permanently diminishing its historical and cultural value for future generations." "Moving Discovery by barge or road would be far more complex [than previous shuttle moves], exposing it to saltwater, weather, and collision risks across a journey several times longer," the letter reads. "As a one-of-a-kind artifact that has already endured the stresses of spaceflight, Discovery is uniquely vulnerable to these hazards. The heat tiles that enabled repeated shuttle missions become more fragile with age, and they are irreplaceable." Kelly, who previously lived in Houston when he was part of the space program, agrees that the city is central to NASA's human spaceflight efforts, but, along with Warner, Kaine, and Durbin, points out that displaying Discovery would come with another cost: an admission fee, limiting public access to the shuttle. "The Smithsonian is unique among museums for providing visitors with access to a national treasure meant to inspire the American public without placing economic barriers," wrote the senators.

Researchers in Texas confirmed the first documented wild hybrid between a blue jay and a green jay -- a rare pairing that is likely a result of climate change and habitat shifts. Slashdot reader fjo3 shares a report from CNN: "We think it's the first observed vertebrate that's hybridized as a result of two species both expanding their ranges due, at least in part, to climate change," said Brian Stokes, a doctoral student of biology at the University of Texas at Austin and first author of the study published September 10 in the journal Ecology and Evolution. The vividly colored green jay is found in parts of South and Central America, Mexico and a limited portion of southern Texas. But since 2000, the tropical bird's territory has expanded north by hundreds of kilometers -- more than 100 miles and about 2 degrees of latitude -- along the Rio Grande and up toward San Antonio, said study coauthor Timothy Keitt.

Avid birders across Central Texas have taken note, sharing sightings of the emerald birds on social media and apps like eBird. Keitt, a professor of integrative biology at UT Austin, has been keeping tabs on their rapid northward creep since 2018. "They're pretty unmistakable in the field," he told CNN. "You see a green jay and you absolutely know that it's a green jay." Stokes joined Keitt's project a few years later, trapping birds to take blood samples for genetic analysis and releasing them back into the wild. While monitoring social media for green jay sightings in May 2023, Stokes came across an intriguing post on a Facebook group called Texbirds. A woman in a suburb of San Antonio shared a photo of an unusual bird that didn't look like any jay Stokes or Keitt had ever seen.

"He happened to notice that this person posted a picture of this odd jay, and immediately told me, and we got in the car and drove down to find it right away," Keitt said. He and Stokes described their finding as one of the "increasingly unexpected outcomes" that arise when global warming and land development converge to drive animal populations to new habitat ranges. This, they wrote, can lead to unpredictable animal interactions -- in this case, between a tropical species and a temperate one -- and create never-before-seen ecological communities.

A review of 62 scientific studies published in Osteoporosis International found that microplastics weaken bones by disrupting bone marrow stem cells and stimulating osteoclasts, cells that degrade bone tissue. Laboratory experiments found the particles reduce cell viability, induce premature cellular aging, modify gene expression, and trigger inflammatory responses. Animal studies found microplastic accumulation decreases white blood cell counts and deteriorates bone microstructure, creating irregular cell structures that increase fracture risk. Rodrigo Bueno de Oliveira from the State University of Campinas in Brazil said the effects interrupted skeletal growth in test animals.

"As awareness grows around the dangers of head trauma in sports, a small number of professional fighters and football players are turning to a psychedelic called ibogaine for treatment," reports the Los Angeles Times.

They note that the drug's proponents "tout its ability to treat addiction, post-traumatic stress disorder and traumatic brain injury, or TBI. " Ibogaine, which is derived from a West African shrub, is a Schedule 1 drug in America with no legal medical uses, and experts urge caution because of the need for further studies. But the results, several athletes say, are "game-changing".... Although athletes are just discovering ibogaine, the drug is well known within the veteran community, which experiences high rates of brain injury and PTSD. In Stanford's study on the effects of ibogaine on special forces veterans, participants saw average reductions of 88% in PTSD symptoms, 87% in depression symptoms and 81% in anxiety symptoms. They also exhibited improvements in concentration, information processing and memory.

"No other drug has ever been able to alleviate the functional and neuropsychiatric symptoms of traumatic brain injury," Dr. Nolan Williams, a professor of psychiatry and behavioral sciences, said in a statement on the results. "The results are dramatic, and we intend to study this compound further...."

States can work faster than the federal government by carving out exemptions for supervised ibogaine therapy programs, similar to what Oregon has done with psilocybin therapy. Many states have also opted to legalize marijuana for medicinal or recreational use... In June, Texas approved a historic $50-million investment in state funding to support drug development trials for ibogaine, inspired by the results seen by veterans. Arizona legislators approved $5 million in state funding for a clinical study on ibogaine in March, and California legislators are pushing to fast-track the study of ibogaine and other psychedelics.

"The internet is full of people claiming to uncover conspiracies in politics and business..." reports the Wall Street Journal.

"Now an unlikely new villain has been added to the list: theoretical physicists," they write, saygin resentment of scientific authority figures "is the major attraction of what might be called 'conspiracy physics'." In recent years, a group of YouTubers and podcasters have attracted millions of viewers by proclaiming that physics is in crisis. The field, they argue, has discovered little of importance in the last 50 years, because it is dominated by groupthink and silences anyone who dares to dissent from mainstream ideas, like string theory... Most fringe theories are too arcane for listeners to understand, but anyone can grasp the idea that academic physics is just one more corrupt and self-serving establishment... In this corner of the internet, the scientist Scott Aaronson has written, "Anyone perceived as the 'mainstream establishment' faces a near-insurmountable burden of proof, while anyone perceived as 'renegade' wins by default if they identify any hole whatsoever in mainstream understanding...

As with other kinds of authorities, there are reasonable criticisms to be made of academic physics. By some metrics, scientific productivity has slowed since the 1970s. String theory has not fulfilled physicists' early dreams that it would become the ultimate explanation of all forces and matter in our universe. The Large Hadron Collider, the world's largest particle accelerator, has delivered fewer breakthroughs than scientists expected when it turned on in 2010. But even reasonable points become hard to recognize when expressed in the ways YouTube incentivizes. Conspiracy physics videos with titles like "They Just Keep Lying" are full of sour sarcasm, outraged facial expressions and spooky music...

Leonard Susskind, director of the Stanford Institute for Theoretical Physics, says physicists need to be both more sober and more forceful when addressing the public. The limits of string theory should be acknowledged, he says, but the idea that progress has slowed isn't right. In the last few decades, he and other physicists have figured out how to make progress on the vast project of integrating general relativity and quantum mechanics, the century-old pillars of physics, into a single explanation of the universe.
The bitter attacks on leading physicists get a succinct summary in the article from Chris Williamson, a "Love Island" contestant turned podcast host. "This is like 'The Kardashians' for physicists — I love it."

The BBC reports that a million-year-old human skull found in China suggests that the human species "began to emerge at least half a million years earlier than we thought, researchers are claiming in a new study." It also shows that we co-existed with other sister species, including Neanderthals, for much longer than we've come to believe, they say.

The scientists claim their analysis "totally changes" our understanding of human evolution and, if correct, it would certainly rewrite a key early chapter in our history. But other experts in a field where disagreement over our emergence on the planet is rife, say that the new study's conclusions are plausible but far from certain.

The discovery, published in the leading scientific journal Science, shocked the research team, which included scientists from a university in China and the UK's Natural History Museum. "From the very beginning, when we got the result, we thought it was unbelievable. How could that be so deep into the past?" said Prof Xijun Ni of Fudan University, who co-led the analysis. "But we tested it again and again to test all the models, use all the methods, and we are now confident about the result, and we're actually very excited."
Thanks to long-time Slashdot reader sinij for sharing the article.

Long-time Slashdot reader theodp says America's Patent and Trademark Office (USPTO) has granted a patent to Tableau (Salesforce's visual analytics platform) — for a patent covering "Data Processing For Visualizing Hierarchical Data": "A provided data model may include a tree specification that declares parent-child relationships between objects in the data model. In response to a query associated with objects in the data model: employing the parent-child relationships to determine a tree that includes parent objects and child objects from the objects based on the parent-child relationships; determining a root object based on the query and the tree; traversing the tree from the root object to visit the child objects in the tree; determining partial results based on characteristics of the visited child objects such that the partial results are stored in an intermediate table; and providing a response to the query that includes values based on the intermediate table and the partial results."

A set of 15 simple drawings is provided to support the legal and tech gobbledygook of the invention claims. A person can have a manager, Tableau explains in Figures 5-6 of its accompanying drawings, and that manager can also manage and be managed by other people. Not only that, Tableau illustrates in Figures 7-10 that computers can be used to count how many people report to a manager. How does this magic work, you ask? Well, you "generate [a] tree" [Fig. 13] and "traverse a tree" [Fig. 15], Tableau explains. But wait, there's more — you can also display the people who report to a manager in multi-level or nested pie charts (aka Sunburst charts), Tableau demonstrates in Fig. 11.

Interestingly, Tableau released a "pre-Beta" Sunburst chart type in late April 2023 but yanked it at the end of June 2023 (others have long-supported Sunburst charts, including Plotly). So, do you think Tableau should be awarded a patent in 2025 on a concept that has roots in circa-1921 Sunburst charts and tree algorithms taught to first-year CS students in circa-1975 Data Structures courses?

"Researchers have modified a standard glue gun to 3D print a bone-like material directly onto fractures," reports LiveScience, "paving the way for its use in operating rooms." The device, which has so far been tested in rabbits, would be particularly useful for fixing irregularly shaped fractures during surgery, the researchers say.

"To my knowledge, there are virtually no previous examples of applying the technology directly as a bone substitute," study co-author Jung Seung Lee, a biomedical engineer at Sungkyunkwan University in South Korea, told Live Science in an email. "This makes the approach quite unique and sets it apart from conventional methods...." "Further studies in larger animal models are needed before the technology can be used on humans," the article points out.

Thanks to long-time Slashdot reader fahrbot-bot for sharing the article.

The heliosphere "plays a major role in why life is possible on our planet," reports CNN, "and how it perhaps once existed on others such as Mars." (Basically solar winds create "a constant flow of charged particles" that form "an enormous bubble that protects the planets in our solar system from cosmic radiation permeating the Milky Way".)

NASA says the heliosphere's boundary is three times the distance between Earth and Pluto. (After leaving the heliosphere NASA's Voyager probes collected key data about the heliosphere.) But now there's a new mission to investigate "how that solar wind interacts with interstellar space at the boundary of the heliosphere," CNN reports — called the Interstellar Mapping and Acceleration Probe (or IMAP): The spacecraft's 10 instruments will also fill gaps in the existing map of the heliosphere, pieced together from data collected by previous missions, and help further explain how the heliosphere largely shields our solar system from damaging cosmic rays, the most highly energetic particles in the universe. Along with two other space weather missions that lifted off aboard the same rocket on Wednesday, IMAP will help scientists better predict when solar storms unleashed by the sun could affect our planet. When aimed at Earth, harsh radiation from the storms, also known as space weather, can pose risks to astronauts on the International Space Station as well as interfere with communications, the electric power grid, navigation, and radio and satellite operations.

"This next set of missions is the ultimate cosmic carpool," said Dr. Joe Westlake, director of NASA's Heliophysics Division, during a news conference on Sunday. "They will provide unprecedented insight into space weather. Every human on Earth, as well as nearly every system involved in space exploration and human needs, is affected by space weather...." The IBEX, or Interstellar Boundary Explorer, satellite has been mapping the heliosphere since launching in 2008. But IMAP can explore and map the boundaries of the heliosphere like never before because it has instruments with faster imaging that are capable of 30 times higher resolution. Once it reaches an orbit about 1 million miles (1.6 million kilometers) from Earth in about three months, IMAP will also capture observations of the solar wind in real time and measure particles that travel from the sun, study the heliosphere's boundary between 6 billion and 9 billion miles (9.7 billion to 14.5 billion kilometers) away, and even collect data from interstellar space.
Also launching was the SWFO-L1 mission, which CNN says is "intended to act as a solar storm detector, providing early warnings to protect astronauts in low-Earth orbit and satellites that provide critical communications on Earth. It's a tool that will be even more necessary as astronauts venture farther into deep space."

NASA streamed the launch live on YouTube.

Doctors report the first successful treatment for Huntington's disease using a new type of gene therapy given during 12 to 18 hours of delicate brain surgery. The BBC reports: An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients. It means the decline you would normally expect in one year would take four years after treatment, giving patients decades of "good quality life", Prof Sarah Tabrizi told BBC News. The first symptoms of Huntington's disease tend to appear in your 30s or 40s and is normally fatal within two decades -- opening the possibility that earlier treatment could prevent symptoms from ever emerging. None of the patients who have been treated are being identified, but one was medically retired and has returned to work. Others in the trial are still walking despite being expected to need a wheelchair. Treatment is likely to be very expensive. However, this is a moment of real hope in a disease that hits people in their prime and devastates families. [...]

It starts with a safe virus that has been altered to contain a specially designed sequence of DNA. This is infused deep into the brain using real-time MRI scanning to guide a microcatheter to two brain regions - the caudate nucleus and the putamen. This takes 12 to 18 hours of neurosurgery. The virus then acts like a microscopic postman -- delivering the new piece of DNA inside brain cells, where it becomes active. This turns the neurons into a factory for making the therapy to avert their own death. The cells produce a small fragment of genetic material (called microRNA) that is designed to intercept and disable the instructions (called messenger RNA) being sent from the cells' DNA for building mutant huntingtin. This results in lower levels of mutant huntingtin in the brain. [...]

The data showed that three years after surgery there was an average 75% slowing of the disease based on a measure which combines cognition, motor function and the ability to manage in daily life. The data also shows the treatment is saving brain cells. Levels of neurofilaments in spinal fluid -- a clear sign of brain cells dying -- should have increased by a third if the disease continued to progress, but was actually lower than at the start of the trial.

An anonymous reader quotes a report from The Guardian: The world's oceans have failed a key planetary health check for the first time, primarily due to the burning of fossil fuels, a report has shown. In its latest annual assessment, the Potsdam Institute for Climate Impact Research said ocean acidity had crossed a critical threshold for marine life. This makes it the seventh of nine planetary boundaries to be transgressed, prompting scientists to call for a renewed global effort to curb fossil fuels, deforestation and other human-driven pressures that are tilting the Earth out of a habitable equilibrium. The report, which follows earlier warnings about ocean acidity, comes at a time of recordbreaking ocean heat and mass coral bleaching.

Oceans cover 71% of the Earth's surface and play an essential role as a climate stabilizer. The new report calls them an "unsung guardian of planetary health", but says their vital functions are threatened. The 2025 Planetary Health Check noted that since the start of the industrial era, oceans' surface pH has fallen by about 0.1 units, a 30-40% increase in acidity, pushing marine ecosystems beyond safe limits. Cold-water corals, tropical coral reefs and Arctic marine life are especially at risk. This is primarily due to the human-caused climate crisis. When carbon dioxide from oil, coal and gas burning enters the sea, it forms carbonic acid. This reduces the availability of calcium carbonate, which many marine organisms depend upon to grow coral, shells or skeletons.

Near the bottom of the food chain, this directly affects species like oysters, molluscs and clams. Indirectly, it harms salmon, whales and other sea life that eat smaller organisms. Ultimately, this is a risk for human food security and coastal economies. Scientists are concerned that it could also weaken the ocean's role as the planet's most important heat absorber and its capacity to draw down 25-30% of the carbon dioxide in the atmosphere. Marine life plays an important role in this process, acting as a "biotic bump" to sequester carbon in the depths. In the report, all of the other six breached boundaries -- climate change, biosphere integrity, land system change, freshwater use, biogeochemical flows, and novel entities -- showed a worsening trend. But the authors said the addition of the only solely ocean-centerd category was a alarming development because of its scale and importance.

NASA aims to launch its first crewed lunar mission in over 50 years, as early as February. The 10-day Artemis II mission will send four astronauts on a lunar flyby to test systems, paving the way for future Moon landings under the Artemis program. The BBC reports: Lakiesha Hawkins, Nasa's acting deputy associate administrator said it would be an important moment in the human exploration of space. "We together have a front row seat to history," she told a news conference this afternoon. "The launch window could open as early as the fifth of February, but we want to emphasize that safety is our top priority." Artemis Launch Director, Charlie Blackwell-Thompson explained that the powerful rocket system built to take the astronauts to the Moon, the Space Launch System (SLS) was "pretty much stacked and ready to go." All that remained was to complete the crew capsule, called Orion, connected to SLS and to complete ground tests.

The Artemis II launch will see four astronauts go on a ten-day round trip to the Moon and back to the Earth. The astronauts, Reid Wiseman, Victor Glover, and Christina Koch, of Nasa and Jeremy Hansen of the Canadian Space Agency, will not land on the Moon, though they will be the first crew to travel beyond low Earth orbit since Apollo 17 in 1972. The lead Artemis II flight director, Jeff Radigan explained that the crew would be flying further into space than anyone had been before. "They're going at least 5,000 nautical miles (9,200Km) past the Moon, which is much higher than previous missions have gone," he told reporters. Further reading: NASA Introduces 10 New Astronaut Candidates