After 170 days in space, four astronauts splashed down in the Atlantic Ocean on Friday, bringing an end to a successful NASA-SpaceX mission to the International Space Station. From a report: Following two days of weather delays, SpaceX's Crew Dragon Freedom returned to Earth off the coast of Jacksonville, Florida, beneath clear blue skies and into mild seas. The spacecraft's descent through Earth's atmosphere appeared to be nominal, with two drogue parachutes deploying on schedule, followed by four clean main parachutes, allowing Dragon to splash down at about 25 km per hour. "SpaceX, from Freedom, thank you for an incredible ride up to orbit and an incredible ride home," Kjell Lindgren, the NASA commander of the spacecraft, said after landing.

Lindgren led a mission that included NASA astronauts Bob Hines and Jessica Watkins, as well as European Space Agency astronaut Samantha Cristoforetti. Upon landing, the spacecraft was met by two SpaceX "fast boats" that secured the toasty-looking vehicle before it was brought on board the Megan recovery ship, named after Megan McArthur, an astronaut aboard an earlier SpaceX flight. This mission, Crew-4, was the fourth operational mission flown by SpaceX for NASA. Earlier this month, the Crew-5 mission launched four astronauts to the space station, where they will remain for about six months. Including an initial demonstration mission in 2020, and two private spaceflights -- Inspiration4 and Axiom-1 -- Crew Dragon has now carried 30 people into orbit.

In a little more than two years, SpaceX has surpassed the total number of astronauts launched into orbit by China, whose human spaceflight program dates back to 2003; and in the time Crew Dragon has been operational, it has exceeded even the Russian Soyuz vehicle in terms of the total number of people flown into space during that period. Over the last two years Dragon had a few flaws, including an intermittently problematic toilet and a lagging parachute on one flight, but NASA officials have been extremely pleased with the vehicle's performance. It has safely returned the United States' capability of human spaceflight, which had been lost since the space shuttle's retirement. Had Dragon not been available, NASA would have been in the uncomfortable position of relying on Russia for crew transport amid the Ukraine war.

NPR reports that astronomers have spotted a black hole finally "burping" out energy from a star that it swallowed back in 2018: How unusual is this? "Super unusual," Yvette Cendes, an astronomer at the Center for Astrophysics, Harvard and Smithsonian and lead author of the paper, tells NPR. "We've never really seen this before to this degree."

Researchers made the discovery when they used a powerful radio telescope facility — the Very Large Array in New Mexico — to check in on some two dozen black holes where stars had been shredded after coming too close to them. That is, the material in the star was pulled apart, or "spaghettified." Such happenings are called tidal disruption events, or TDEs....

"There's a point when you get too close to a black hole that you can no longer escape the black hole — that's called the event horizon. But this material never crossed that boundary, according to our best estimates," Cendes explains. In other words, the star got close enough to the black hole to get shredded — but not to fall into that point of no return.
But that's not what's unusual about it. Mashable picks up the story, noting it's a black hole, at the center of a galaxy some 665 million light-years from Earth: It's the fact that this star apparently didn't sit well with the black hole for such a long time that surprised them. Researchers have been studying these events with radio telescopes for more than a decade, said Edo Berger, a Harvard astronomy professor and co-author. "There was radio silence for the first three years in this case," Berger said in a statement.

"And now it's dramatically lit up to become one of the most radio luminous ... ever observed."

The discovery suggests that delayed outflows of light from a black hole after swallowing a cosmic object could be happening more often than thought.

Ugur Sahin and and Özlem Türeci. The BBC calls them "the husband and wife team behind one of the most successful Covid vaccines" — the couple who co-founded the German biotech company BioNTech in 2008, "exploring new technology involving messenger RNA to treat cancer."

And though they partnered with Pfizer to ues the same approach for their Covid vaccine, "Now the doctors are hopeful it could lead to new treatments for melanoma, bowel cancer and other tumour types." BioNTech has several trials in progress, including one where patients are given a personalised vaccine, to prompt their immune system to attack their disease. The mRNA technology being used works by sending an instruction or blueprint to cells to produce an antigen or protein. In Covid this antigen is part of the spike protein of the virus. In cancer it would be a marker on the surface of tumour cells. This teaches the immune system to recognise and target affected cells for destruction.

Speaking on the BBC's Sunday with Laura Kuenssberg, Prof Tureci said: "mRNA acts as a blueprint and allows you to tell the body to produce the drug or the vaccine... and when you use mRNA as a vaccine, the mRNA is a blueprint for the 'wanted poster' of the enemy — in this case cancer antigens which distinguish cancer cells from normal cells."

Harnessing the power of mRNA to produce vaccines was unproven until Covid. But the success of mRNA vaccines in the pandemic has encouraged scientists working with the technology in cancer.
The Guardian notes that the couple said cancer-targetting vaccines could be available "before 2030", though Özlem Türeci warns that "As scientists we are always hesitant to say we will have a cure for cancer. We have a number of breakthroughs and we will continue to work on them." BioNTech was working on mRNA cancer vaccines before the pandemic struck but the firm pivoted to produce Covid vaccines in the face of the global emergency. The firm now has several cancer vaccines in clinical trials.

"Europe is aiming to launch a technology demonstration satellite for secure, quantum-encrypted communications in 2024," reports Space.com, "with a view to developing a larger constellation." The satellite, Eagle-1, will be the first space-based quantum key distribution (QKD) system for the European Union and could lead to an ultrasecure communications network for Europe, according to a statement from the European Space Agency (ESA).

Eagle-1 will spend three years in orbit testing the technologies needed for a new generation of secure communications. The satellite will demonstrate the "feasibility of quantum key distribution technology — which uses the principles of quantum mechanics to distribute encryption keys in such a way that any attempt to eavesdrop is immediately detected — within the EU using a satellite-based system," according to ESA...

"European security and sovereignty in a future world of quantum computing is critical to the success of Europe and its Member States," Steve Collar, CEO of SES, said in the statement. He added that the goal is "to advance quantum communications and develop the Eagle-1 system to support secure and sovereign European networks of the future."
SES will be leading a consortium of more than 20 European countries, according to the ESA's statement: Eagle-1 will demonstrate the feasibility of quantum key distribution technology — which uses the principles of quantum mechanics to distribute encryption keys in such a way that any attempt to eavesdrop is immediately detected — within the EU using a satellite-based system. To do so, the system will build on key technologies developed under ESA's Scylight programme, with the aim of validating vital components supplied within the EU....

It will allow the EU to prepare for a sovereign, autonomous cross-border quantum secure communications network.

The system will initially use an upgraded optical ground terminal from the German Aerospace Centre (DLR) alongside a new optical ground terminal to be developed by a team from the Netherlands. The Eagle-1 platform satellite from Italian company Sitael will carry a quantum-key payload built by Tesat Spacecom of Germany and will be operated by Luxembourg-headquartered SES.

"For the last century the biggest bar fight in science has been between Albert Einstein and himself," reports the New York Times: On one side is the Einstein who in 1915 conceived general relativity, which describes gravity as the warping of space-time by matter and energy. That theory predicted that space-time could bend, expand, rip, quiver like a bowl of Jell-O and disappear into those bottomless pits of nothingness known as black holes. On the other side is the Einstein who, starting in 1905, laid the foundation for quantum mechanics, the nonintuitive rules that inject randomness into the world — rules that Einstein never accepted. According to quantum mechanics, a subatomic particle like an electron can be anywhere and everywhere at once, and a cat can be both alive and dead until it is observed. God doesn't play dice, Einstein often complained.

Gravity rules outer space, shaping galaxies and indeed the whole universe, whereas quantum mechanics rules inner space, the arena of atoms and elementary particles. The two realms long seemed to have nothing to do with each other; this left scientists ill-equipped to understand what happens in an extreme situation like a black hole or the beginning of the universe.

But a blizzard of research in the last decade on the inner lives of black holes has revealed unexpected connections between the two views of the cosmos. The implications are mind-bending, including the possibility that our three-dimensional universe — and we ourselves — may be holograms, like the ghostly anti-counterfeiting images that appear on some credit cards and drivers licenses. In this version of the cosmos, there is no difference between here and there, cause and effect, inside and outside or perhaps even then and now; household cats can be conjured in empty space. We can all be Dr. Strange.

"It may be too strong to say that gravity and quantum mechanics are exactly the same thing," Leonard Susskind of Stanford University wrote in a paper in 2017. "But those of us who are paying attention may already sense that the two are inseparable, and that neither makes sense without the other."

That insight, Dr. Susskind and his colleagues hope, could lead to a theory that combines gravity and quantum mechanics — quantum gravity — and perhaps explains how the universe began.

Long-time Slashdot reader orsayman writes: Remember the MICROSCOPE satellite ? In 2017, based on its first results, scientists were able to confirm Einstein's equivalence principle (a key assumption in General Relativity) to unprecedented precision.

Recently, they were able to improve precision by almost another order of magnitude by using all the data. Fortunately (or not) no violation of the principle was detected which could help physicists to improve their theories of quantum gravity.

Apparently the team expects to send a new mission "in the second half of the 2030s" aiming for another huge improvement in precision.

Long-time Slashdot reader mspohr shares a report from the Boston Globe's health-news site STAT: The scientist flicked on a laser, filling the rat's brain with blue light. The rodent, true to its past two weeks of training, scampered across its glass box to a tiny spout, where it was duly rewarded with a drink of water. From the outside, this would appear to be a pretty run-of-the-mill neuroscience experiment, except for the fact that the neurons directing the rat to its thirst-quenching reward didn't contain any rat DNA. Instead, they came from a human "mini-brain" — a ball of human tissue called an organoid — that researchers at Stanford University School of Medicine had grown in a lab and implanted in the rodent's cortex months before.

The experiment — part of a study published Wednesday in Nature — is the first describing human neurons influencing another species' behavior. The study also showed that signals could go the other way; tendrils of human neurons mingled with the rodent brain cells and fired in response to air rustling the rats' whiskers.

The advance opens the door to using such human-rodent chimeras to better understand how the human brain develops and what goes wrong in neurological and psychiatric conditions such as schizophrenia, autism, and epilepsy. When the Stanford scientists implanted organoids grown from the cells of patients with a severe genetic brain disorder, they could watch the neurons develop abnormally with unprecedented clarity.

"This paper really pushes the envelope," said neuroscientist Tomasz Nowakowski, of the University of California, San Francisco, who uses brain organoids in his research on neurodevelopmental disorders but was not involved in the new work. "The field is desperate for more experimental models. And what's really important about this study is it demonstrates that brain organoids can complete their maturation trajectory when transplanted. So it really expands our toolkit for asking more nuanced questions about how genetic mutations lead to behavioral disorders."
It's an example of how stem cells have revolutionized brain research. By "doing their experiments in very young rats whose cortexes are not yet saturated with synapses," the article points out, the researchers "found that the human neurons easily integrated into the animals' rapidly expanding circuitry, which provided them with the stimulation they needed to push past previous developmental barriers."

An anonymous reader quotes a report from NPR: The FDA has confirmed the nation is experiencing a shortage of Adderall after many pharmacies around the country have been unable to fill prescriptions and keep up with demand. The drug, which is also known as mixed amphetamine salts, is used to treat attention-deficit/hyperactivity disorder (ADHD) and narcolepsy. "We will continue to monitor supply and assist manufacturers with anything needed to resolve the shortage and will update our website with new supply information as it becomes available," the FDA said.

Expected recovery times for manufacturers' supplies of the prescription vary. Teva Pharmaceuticals, which sells the most Adderall in the U.S., has a 10 mg dosage of Adderall that is expected to rebound in October. But many of its generic brand offerings aren't expected to recover until March 2023. Manufacturer SpecGX's higher doses won't recoup until January 2023, while Rhodes Pharmaceuticals has a shortage of an active ingredient. Bloomberg health reporter Ike Swetlitz told NPR last month the shortages began due to a labor shortage at Teva, causing production delays that began showing up at other companies. Additionally, an increase in ADHD diagnoses has been driving up demand for Adderall in recent years.

SpaceX returned its fourth operational crew mission from the International Space Station on Friday, with the quartet of astronauts splashing down in the company's capsule off the coast of Florida. CNBC reports: The company's Crew Dragon spacecraft "Freedom" undocked from the ISS at around noon ET to begin the trip back to Earth, with splashdown happening around 5 p.m. ET. "Welcome home -- thanks for flying SpaceX," the company's mission control told the crew shortly after landing. "Thank you for an incredible ride to orbit, and an incredible ride home," Crew-4 commander Kjell Lindgren said in response.

Crew-4 includes NASA astronauts Lindgren, Bob Hines, and Jessica Watkins, as well as European Space Agency astronaut Samantha Cristoforetti. The mission launched in April for a six-month stay on the orbiting research laboratory. Elon Musk's company launched the Crew-5 mission last week, bringing four other astronauts to the ISS. SpaceX has now flown 30 people to orbit since its first crewed launch in May 2020, with six government missions and two private ones.

Global animal populations are declining, and we've got limited time to try to fix it. From a report: That's the upshot of a new report from the World Wildlife Fund and the Zoological Society of London, which analyzed years of data on thousands of wildlife populations across the world and found a downward trend in the Earth's biodiversity. According to the Living Planet Index, a metric that's been in existence for five decades, animal populations across the world shrunk by an average of 69% between 1970 and 2018. Not all animal populations dwindled, and some parts of the world saw more drastic changes than others. But experts say the steep loss of biodiversity is a stark and worrying sign of what's to come for the natural world. "The message is clear and the lights are flashing red," said WWF International Director General Marco Lambertini. According to the report's authors, the main cause of biodiversity loss is land-use changes driven by human activity, such as infrastructure development, energy production and deforestation. But the report suggests that climate change -- which is already unleashing wide-ranging effects on plant and animal species globally -- could become the leading cause of biodiversity loss if rising temperatures aren't limited to 1.5C.

A study of tens of thousands of people in Scotland found that one in 20 people who had been sick with Covid reported not recovering at all, and another four in 10 said they had not fully recovered from their infections many months later. From a report: The authors of the study, published on Wednesday in the journal Nature Communications, tried to home in on the long-term risks of Covid by comparing the frequency of symptoms in people with and without previous Covid diagnoses. People with previous symptomatic Covid infections reported certain persistent symptoms, such as breathlessness, palpitations and confusion or difficulty concentrating, at a rate roughly three times as high as uninfected people in surveys from six to 18 months later, the study found. Those patients also experienced elevated risks of more than 20 other symptoms relating to the heart, respiratory health, muscle aches, mental health and the sensory system.

The findings strengthened calls from scientists for more expansive care options for long Covid patients in the United States and elsewhere, while also offering some good news. The study did not identify greater risks of long-term problems in people with asymptomatic coronavirus infections. It also found, in a much more limited subset of participants who had been given at least one dose of Covid vaccine before their infections, that vaccination appeared to help reduce if not eliminate the risk of some long Covid symptoms. People with severe initial Covid cases were at higher risk of long-term problems, the study found.

The White House is coordinating a five-year research plan to study ways of modifying the amount of sunlight that reaches the earth to temper the effects of global warming, a process sometimes called solar geoengineering or sunlight reflection. From a report: The research plan will assess climate interventions, including spraying aerosols into the stratosphere to reflect sunlight back into space, and should include goals for research, what's necessary to analyze the atmosphere, and what impact these kinds of climate interventions may have on Earth, according to the White House's Office of Science and Technology Policy. Congress directed the research plan be produced in its spending plan for 2022, which President Joe Biden signed in March.

Some of the techniques, such as spraying sulfur dioxide into the atmosphere, are known to have harmful effects on the environment and human health. But scientists and climate leaders who are concerned that humanity will overshoot its emissions targets say research is important to figure out how best to balance these risks against a possibly catastrophic rise in the Earth's temperature. Getting ready to research a topic is a very preliminary step, but it's notable the White House is formally engaging with what has largely been seen as the stuff of dystopian fantasy. In Kim Stanley Robinson's science fiction novel, "The Ministry for the Future," a heat wave in India kills 20 million people and out of desperation, India decides to implement its own strategy of limiting the sunlight that gets to Earth. Chris Sacca, the founder of climate tech investment fund Lowercarbon Capital, said it's prudent for the White House to be spearheading the research effort.

Sony has announced the availability of its first OTC hearing aids, the $1,000 CRE-C10 and $1,300 CRE-E10, built in partnership with WS Audiology. Engadget reports: The devices are built for daily use for those with mild to moderate hearing loss. They're controlled via Sony's "Hearing Control" app that guides users through setup and allows them to personalize settings like volume control. It also allows a "self-fit" that adjusts to appropriate pre-defined hearing profiles "based on thousands of actual, real-life audiogram results," Sony said. The CRE-C10 model (above) offers a battery life of up to 70 hours of continuous use. Sony says they're one of the smallest OTC hearing aids on the market, offering a discreet design that's "virtually invisible when worn" and "exceptional sound quality." It goes on sale this month for $1,000 at Amazon, Best Buy, and select hearing-care professionals.

Meanwhile, the CRE-E10 has a more earbud-like design, powered by a rechargeable battery with up to 26 hours of life between charges. It's Bluetooth compatible as well, so users can connect to devices and listen to streaming audio or music, though only on iOS, Sony says. Those will go on sale for $1,300 sometime this winter at Sony's website. In August, the FDA decided to allow hearing aids to be sold over the counter and without a prescription to adults.

Last week, DeepMind announced it discovered a more efficient way to perform matrix multiplication, conquering a 50-year-old record. This week, two Austrian researchers at Johannes Kepler University Linz claim they have bested that new record by one step. Ars Technica reports: In 1969, a German mathematician named Volker Strassen discovered the previous-best algorithm for multiplying 4x4 matrices, which reduces the number of steps necessary to perform a matrix calculation. For example, multiplying two 4x4 matrices together using a traditional schoolroom method would take 64 multiplications, while Strassen's algorithm can perform the same feat in 49 multiplications. Using a neural network called AlphaTensor, DeepMind discovered a way to reduce that count to 47 multiplications, and its researchers published a paper about the achievement in Nature last week.

To discover more efficient matrix math algorithms, DeepMind set up the problem like a single-player game. The company wrote about the process in more detail in a blog post last week. DeepMind then trained AlphaTensor using reinforcement learning to play this fictional math game -- similar to how AlphaGo learned to play Go -- and it gradually improved over time. Eventually, it rediscovered Strassen's work and those of other human mathematicians, then it surpassed them, according to DeepMind. In a more complicated example, AlphaTensor discovered a new way to perform 5x5 matrix multiplication in 96 steps (versus 98 for the older method).

This week, Manuel Kauers and Jakob Moosbauer of Johannes Kepler University in Linz, Austria, published a paper claiming they have reduced that count by one, down to 95 multiplications. It's no coincidence that this apparently record-breaking new algorithm came so quickly because it built off of DeepMind's work. In their paper, Kauers and Moosbauer write, "This solution was obtained from the scheme of [DeepMind's researchers] by applying a sequence of transformations leading to a scheme from which one multiplication could be eliminated."

Climate change may be having more impact on the melting Greenland ice sheet than previously thought, new research suggests. From a report: The study found rising air temperatures amplify the effects of melting caused by ocean warming, leading to greater ice loss from the world's second largest ice sheet. Experts liken the effect to how ice cubes melt more quickly if they are in a drink that is being stirred -- the combination of warmer liquid and movement accelerates the melting process. Previous studies have shown that rising air and ocean temperatures both cause the Greenland ice sheet to melt, however the new study, by researchers from the universities of Edinburgh and California San Diego, reveals how one intensifies the effects of the other.

Dr Donald Slater, of the University of Edinburgh's School of GeoSciences, who led the study, said: "The effect we investigated is a bit like ice cubes melting in a drink -- ice cubes will obviously melt faster in a warm drink than in a cold drink, hence the edges of the Greenland ice sheet melt faster if the ocean is warmer. But ice cubes in a drink will also melt faster if you stir the drink, and rising air temperatures in Greenland effectively result in a stirring of the ocean close to the ice sheet, causing faster melting of the ice sheet by the ocean."