An anonymous reader quotes a report from New Atlas: The universe is awash with strange radio signals, but astronomers have now detected a really bizarre one that repeats every hour, cycling through three different states. While they have some ideas about its origin it can't be explained by our current understanding of physics. The signal first appeared in data gathered by the ASKAP radio telescope in Australia, which watches a big swath of sky at once for transient pulses. Officially designated ASKAP J1935+2148, the signal seems to repeat every 53.8 minutes. Whatever it is, the signal cycles through three different states. Sometimes it shoots out bright flashes that last between 10 and 50 seconds and have a linear polarization, meaning the radio waves all "point" in the same direction. Other times, its pulses are much weaker with a circular polarization, lasting just 370 milliseconds. And sometimes, the object misses its cue and stays silent.

So what could be behind such a weird radio signal? Let's get it out of the way up front: it's not aliens (probably). The most likely explanation, according to the scientists who discovered it, is that it's coming from a neutron star or a white dwarf. But it's not a neat solution, since the signal's weird properties don't fit with our understanding of the physics of those two kinds of objects. Neutron stars and white dwarfs are fairly similar, but with some key differences. They're both born from the deaths of bigger stars, with the original mass dictating whether you end up with a neutron star or a white dwarf. Neutron stars are known to blast radio waves out regularly, so they're a prime suspect here. It's possible that signals this varied could be produced by interactions between their strong magnetic fields and complex plasma flows. But there's a major problem: they usually spin at speeds of seconds or fractions of a second per revolution. It should be physically impossible for one to spin as slow as once every 54 minutes. White dwarfs, on the other hand, would have no problem spinning that slowly, but as the team says, "we don't know of any way one could produce the radio signals we are seeing here." "It might even prompt us to reconsider our decades-old understanding of neutron stars or white dwarfs; how they emit radio waves and what their populations are like in our Milky Way galaxy," added Caleb.

The findings have been published in the journal Nature Astronomy.

Longtime Slashdot reader destinyland shared a story from Space.com reporting on Boeing's missed opportunity to dock with the International Space Station, after five of the 28 thrusters that help control Starliner's movement in space stopped operating. NASA has since been able to recover four of the thrusters to successfully dock Boeing's Starliner capsule with the ISS. From the report: There are now two U.S.-built crew spacecraft docked with the ISS for the first time. Boeing's Starliner joined SpaceX's Dragon capsule "Endeavour," which arrived in March. Boeing's Starliner launched successfully on Wednesday to begin the crew flight test. The mission represents a final major step before NASA certifies Boeing to fly crew on operational missions. [...]

NASA flight controllers called off a previously scheduled approach to resolve issues with Starliner's propulsion system. Starliner has 28 jets, known as its reaction control system, or RCS, engines, that help the spacecraft make small movements in orbit. The crew on Starliner, NASA astronauts Butch Wilmore and Suni Williams, were told by NASA capsule communicator, or CAPCOM, Neal Nagata, that the 12:15 p.m. docking attempt had to be called off to resolve the spacecraft's propulsion issue. CAPCOM Nagata noted that the ISS has a zero fault tolerance for a spacecraft control problem.

The agency and Boeing had to troubleshoot five of the RCS jets that were not operating. Four of Starliner's malfunctioning jets were recovered after Wilmore and Williams worked with flight controllers to test fire the thrusters. CAPCOM Nagata had the astronauts hold the spacecraft beyond the "keep out sphere," an invisible boundary around the ISS that serves as a safety measure, while diagnosing the problematic thrusters.

New submitter OwnedByTwoCats writes: SpaceX's Starship, the most powerful launch vehicle ever built, launched Thursday and achieved key objectives laid out for its fourth test flight that demonstrated the vehicle's reusability. The highly anticipated event was the company's second uncrewed test of 2024. Launch occurred from the private Starbase facility in Boca Chica, Texas, at 7:50 a.m. CT (8:50 a.m. ET), and the company streamed live coverage on X, formerly known as Twitter, drawing millions of viewers.

The Starship launch system includes the upper Starship spacecraft and a rocket booster known as the Super Heavy. Of the rocket's 33 engines, 32 lit during launch, according to the SpaceX broadcast. The vehicle soared through multiple milestones during Thursday's test flight, including the survival of the Starship capsule upon reentry during peak heating in Earth's atmosphere and splashdown of both the capsule and booster. After separating from the spacecraft, the Super Heavy booster for the first time successfully executed a landing burn and had a soft splashdown in the Gulf of Mexico about eight minutes after launch.

Meanwhile, the Starship capsule successfully achieved orbital insertion. About 50 minutes after launch, the spacecraft began its controlled reentry journey, and an incredibly colorful buildup of plasma could be seen around the vehicle as its heat shield faced the extreme temperatures of Earth's atmosphere. The company's Starlink satellites helped facilitate a livestream that was continuously available during reentry. A flap near the camera view on Starship appeared to scorch during reentry and particulate matter blocked some of the view of the camera. But in the end, there was enough of a view to see Starship achieve its expected landing burn into the Indian Ocean.

Slashdot readers destinyland and LazarusQLong share a report from CNN: The third attempt was the charm for Boeing's Starliner mission after launching its first crewed flight test Wednesday in a milestone that has been a decade in the making. The new spacecraft's maiden voyage with humans on board lifted off atop an Atlas V rocket at 10:52 a.m. ET from Cape Canaveral Space Force Station in Florida.

Veteran NASA astronauts Butch Wilmore and Suni Williams are riding aboard the Starliner capsule on a journey that takes them to the International Space Station. The mission, known as the Crew Flight Test, is the culmination of Boeing's efforts to develop a spacecraft to rival SpaceX's Crew Dragon capsule and expand the United States' options for ferrying astronauts to the space station under NASA's Commercial Crew Program. The federal agency's initiative aims to foster collaboration with private industry partners.

The flight marks only the sixth inaugural journey of a crewed spacecraft in US history, NASA Administrator Bill Nelson noted in a May news conference. "It started with Mercury, then with Gemini, then with Apollo, the space shuttle, then (SpaceX's) Dragon -- and now Starliner," Nelson said. Williams also made history as the first woman to fly aboard such a mission. NASA has a live recording of the launch on YouTube.

The 34-year-old Hubble Space Telescope is now operating with its final two working gyroscopes, necessitating a switch to a less productive "one-gyro" mode to extend its operational life. This contingency plan will reduce Hubble's productivity by over 12%, limit its ability to track fast-moving objects, and decrease the portion of the sky it can observe. That said, NASA expects it to keep functioning through 2035. Science.org reports: Normally, Hubble measures its location in space with a system that includes three gyroscopes -- rapidly spinning wheels that can sense forces in three directions. But in a 4 June press conference, NASA officials said one of the telescope's three remaining gyroscopes is on the fritz. The agency is now invoking a contingency plan: a "one-gyro" mode that keeps the other functioning gyroscope in reserve. The mode will reduce the telescope's productivity by more than 12% but preserve its ability to observe for years to come, Mark Clampin, NASA's astrophysics division director, said at the press conference. "We believe this is our best approach to support Hubble science through this decade and into the next."

Hubble's gyroscopes, which spin at 19,200 revolutions per minute, are extremely precise but finicky. The agency has flown a total of 22 gyroscopes across various servicing missions and is now down to the last two of the six currently onboard. In one-gyro mode, Hubble must rely on its less precise star trackers and other sensors to verify its position, a slower process that leads to reduced productivity. "It will take us more time to slew from one target attitude to the next, and to be able to lock on to that science target," said Patrick Crouse, Hubble's project manager at NASA's Goddard Space Flight Center.

A one-gyro Hubble will also struggle to track fast-moving targets, such as asteroids within the orbit of Mars, and to swivel to spot transient distant phenomena such as supernovae, according to a 2016 report (PDF) from the Space Telescope Science Institute, which operates Hubble. In addition, the inefficiencies of one-gyro mode will reduce the portion of the sky that Hubble can safely point to at any given moment, from 82% to roughly 40%, including a larger avoidance zone near the Sun. It won't be able to observe Venus or the Moon, nor will it be able to reliably spot comets when they're near the Sun. Its ability to scrutinize distant exoplanets will also be hampered, especially in gathering the spectral measurements used to discern alien atmospheres. Furthermore, a one-gyro Hubble won't be able to perform as many simultaneous observations with the new JWST space observatory. Moving forward, the two telescopes' fields of view at any given moment may overlap by less than 20%, according to a 2019 estimate anticipating this event from a Hubble advisory committee.

By 2050, 61% of U.S. adults will have cardiovascular disease, driven mainly by high blood pressure, according to new American Heart Association research. High blood pressure significantly increases the risk of heart attacks, strokes, and other dangerous cardiovascular problems. The findings also point to ongoing challenges with arrhythmias, heart failure, and congenital heart disease. CNN: In the research published Tuesday, the association predicts that 45 million adults will have some form of cardiovascular disease -- excluding high blood pressure -- or will have a stroke in 2050, up from 28 million in 2020. An aging population will be another force behind these trends, as the older you get, the more likely you are to have heart problems.

By 2050, 22% of the US will be over the age of 65, whereas seniors made up just 13% of the population 10 years ago, studies say. The median age in the US is projected to increase from 37 in 2010 to 41 in 2050, other research shows. The American population is also becoming more diverse, and communities of color tend to have a disproportionate number of heart problems. By 2050, people who identify as Hispanic will make up about a quarter of the US population, vs. about 20% today, and people who identify as Black will be 14.4% of the country, up from 13.6% today. The number of people who identify as Asian will also increase, from 6.2% of the population to 8.6%, according to US Census predictions.

Due to complications with a mechanical heart pump, surgeons in New York removed a pig kidney from Lisa Pisano less than two months after transplanting it. The genetically engineered pig kidney did not show signs of rejection but suffered from inadequate blood flow. Wired reports: Pisano was facing heart and kidney failure and required routine dialysis. She wasn't eligible to receive a traditional heart and kidney transplant from a human donor because of several chronic medical conditions that reduced the likelihood of a good outcome. Pisano first received a heart pump at NYU Langone Health on April 4, followed by the pig kidney transplant on April 12. The heart pump, a device called a left ventricular assist device or LVAD, is used in patients who are either awaiting heart transplantation or otherwise aren't a candidate for a heart transplant.

In a statement provided to WIRED, Pisano's medical team explained that they electively removed the pig kidney on May 29-47 days after transplant -- after several episodes of the heart pump not being able to pass enough blood through the transplanted kidney. Steady blood flow is important so that the kidney can produce urine and filter waste. Without it, Pisano's kidney function began to decline. "On balance, the kidney was no longer contributing enough to justify continuing the immunosuppression regimen," said Robert Montgomery, director of the NYU Langone Transplant Institute, in the statement. Like traditional transplant patients, Pisano needed to take immunosuppressive drugs to prevent her immune system from rejecting the donor organ.

The kidney came from a pig genetically engineered by Virginia biotech company Revivicor to lack a gene responsible for the production of a sugar known as alpha-gal. In previous studies at NYU Langone, researchers found that removing this sugar prevented immediate rejection of the organ when transplanted into brain-dead patients. During Pisano's surgery, the donor pig's thymus gland, which is responsible for "educating" the immune system, was also transplanted to reduce the likelihood of rejection. A recent biopsy did not show signs of rejection, but Pisano's kidney was injured due to a lack of blood flow, according to the statement. The team plans to study the explanted pig kidney to learn more.

Gizmodo reports there's been progress on a male birth-control gel "being developed with the help of several organizations, including the U.S. government's National Institute of Child Health and Human Development, part of the larger NIH." It's now being tested in a larger-scale Phase IIB trial, which involves around 400 couples. [Five milliliters of gel — about a teaspon — is applied to each shoulder blade once a day, reports NBC News.] That trial is still ongoing, but researchers have already begun to pore through some of the available data, which has provided encouraging results. In the summer of 2022, for instance, Diana Blithe, chief of the NICHD's Contraceptive Development Program, reported that the NES/T gel's efficacy rate so far appeared to be on par or even better than contraceptive hormonal options for women...

The findings are still preliminary, and it will take more time for the full Phase II data to be collected and analyzed. But Blithe and her team have been encouraged by everything they've seen to date. In the team's early assessments, the gel appears to be both effective and safe, with minimal side effects for men taking it... Blithe and her colleagues are set to meet with the FDA next year about the steps needed to begin a larger Phase III trial and are still seeking a commercial partner to help bring the NES/T gel to the market.
Initial findings also showed that the contraceptive worked faster than expected, Blithe said, according to NBC News. They add that at least three other companies are also working on male birth control: Also at the Boston conference on Sunday, YourChoice Therapeutics said a very small trial in the U.K. — just 16 men — showed that its nonhormonal pill, YCT-529, was safe and free of side effects. The San Francisco company's nonhormonal pill works by blocking the vitamin A receptor important for male fertility.YourChoice is planning a larger trial, according to CEO Akash Bakshi.

Will appetite-suppressing drugs hurt the sugar industry? Executives from Walmart warned that Ozempic and Zepbound "are impacting food sales," reports Bloomberg, "and multiple analyst surveys have showed that less-hungry customers are spending fewer dollars at grocery stores and restaurants." The drugs, which cut cravings, will result in a decline in calorie consumption in the US of 1.5% to 2.5% by 2035, with a drop of as much as 5% in the consumption of sweets such as baked goods, confectionery and soda, Morgan Stanley analysts including Pamela Kaufman said in a report last month. Morgan Stanley forecast about a 10th of the US population will be on the so-called GLP-1 medications — originally designed to treat diabetes but being used by many as a powerful weight-loss tool — by 2035... Even with tight supplies and sky-high prices limiting uptake of the medications, sales of GLP-1 drugs for both obesity and diabetes already exceeded $19 billion in 2023. The global obesity market alone could top $100 billion by the end of the decade, Goldman Sachs Group Inc. estimates, while Bloomberg Intelligence forecasts $80 billion of sales.

More than 60% of US consumers taking the drugs said they had cut back on sweet treats like candy, ice cream and baked goods, and many said they had either significantly — or entirely — stopped eating those products, according to Morgan Stanley.

"Chinese scientists develop cure for diabetes," reads the headline from the world's second-most widely read English-language newspaper. ("Insulin patient becomes medicine-free in just 3 months.")

The researchers' results were published earlier in May in Cell Discovery, and are now getting some serious scrutiny from the press. The Economic Times cites a University of British Columbia professor's assessment that the study "represents an important advance in the field of cell therapy for diabetes," in an article calling it a "breakthrough" that "marks a significant advancement in cell therapy for diabetes." Chinese scientists have successfully cured a patient's diabetes using a groundbreaking cell therapy... According to a South China Morning Post report, the patient underwent the cell transplant in July 2021. Remarkably, within eleven weeks, he no longer required external insulin. Over the next year, he gradually reduced and ultimately stopped taking oral medication for blood sugar control. "Follow-up examinations showed that the patient's pancreatic islet function was effectively restored," said Yin, one of the lead researchers. The patient has now been insulin-free for 33 months... The new therapy involves programming the patient's peripheral blood mononuclear cells, transforming them into "seed cells" to recreate pancreatic islet tissue in an artificial environment.
Their article calls it "a significant medical milestone" — noting that 140 million people in China have diabetes (according to figures from the International Diabetes Federation).

Thanks to long-time Slashdot reader AmiMoJo for sharing the news.

China's Chang'e-6 probe successfully lands on far side of the moon China's moon probe has "successfully touched down on the far side of the moon," CNN reports, in "a significant step for the ambitious mission that could advance the country's aspirations of putting astronauts on the moon" by 2030.

The mission's ultimate goal is to return to Earth the first samples from the moon's far side, CNN reports. And China's lunar lander "is now expected to use a drill and a mechanical arm to gather up to 2 kilograms of moon dust and rocks from the basin, a crater formed some 4 billion years ago." To complete its mission, the lander will need to robotically stow those samples in an ascent vehicle that made the landing with it. The ascent vehicle will then return to lunar orbit, where it will dock with and transfer the samples to a re-entry capsule, according to mission information provided by the China National Space Administration. The re-entry capsule and orbiter will then travel back to Earth's orbit and separate, allowing the re-entry capsule to make its expected return later this month to the Siziwang Banner Landing Site in China's rural Inner Mongolia region.
The mission began with its launch on May 3 — and is expected to last 53 days. The landing marks the second time a mission has successfully reached the far side of the moon. China first completed that historic feat in 2019 with its Chang'e-4 probe... The technically complex mission is made more challenging due to where it is being conducted. The far side of the moon is out of range of normal communications, which means Chang'e-6 must also rely on a satellite that was launched into lunar orbit in March, the Queqiao-2.

"The seemingly star-cross Boeing Starliner — within minutes of its long-delayed blastoff on the spacecraft's first piloted test flight — was grounded again Saturday," writes CBS News, "when one of three redundant computers managing the countdown from the base of the launch pad ran into a problem, triggering a last-minute scrub."

More details from NPR: With 3:50 left in the countdown, the rocket's computer initiated a hold. The next launch attempt won't happen until at least Wednesday, NASA said.

An issue with one of the three redundant computer systems at the base of the launch pad that are responsible for initiating the launch sequence prompted the automatic halt, said Tory Bruno, the head of United Launch Alliance, the government contractor trying to launch the Starliner. "We do require all three systems to be running — triple redundancy," ULA President and CEO Bruno said at a Saturday afternoon press briefing. "Those three big computers do a health check. ... Two came up normally. The third one came up, but it was slow to come up, and that tripped a red line that created an automatic hold." ULA engineers don't know why the computer halted, and will troubleshoot ground support equipment overnight, NASA said in an update on Saturday evening.

"A Swiss biocomputing startup has launched an online platform that provides remote access to 16 human brain organoids," reports Tom's Hardware: FinalSpark claims its Neuroplatform is the world's first online platform delivering access to biological neurons in vitro. Moreover, bioprocessors like this "consume a million times less power than traditional digital processors," the company says. FinalSpark says its Neuroplatform is capable of learning and processing information, and due to its low power consumption, it could reduce the environmental impacts of computing. In a recent research paper about its developments, FinalSpakr claims that training a single LLM like GPT-3 required approximately 10GWh — about 6,000 times greater energy consumption than the average European citizen uses in a whole year. Such energy expenditure could be massively cut following the successful deployment of bioprocessors.

The operation of the Neuroplatform currently relies on an architecture that can be classified as wetware: the mixing of hardware, software, and biology. The main innovation delivered by the Neuroplatform is through the use of four Multi-Electrode Arrays (MEAs) housing the living tissue — organoids, which are 3D cell masses of brain tissue...interfaced by eight electrodes used for both stimulation and recording... FinalSpark has given access to its remote computing platform to nine institutions to help spur bioprocessing research and development. With such institutions' collaboration, it hopes to create the world's first living processor.
FinalSpark was founded in 2014, according to Wikipedia's page on wetware computing. "While a wetware computer is still largely conceptual, there has been limited success with construction and prototyping, which has acted as a proof of the concept's realistic application to computing in the future."

Thanks to long-time Slashdot reader Artem S. Tashkinov for sharing the article.

On June 3, a "planet parade" of six planets -- Jupiter, Mercury, Uranus, Mars, Neptune and Saturn -- will form a straight line through the pre-dawn sky. Astronomy.com reports: Some 20 minutes before sunrise, all six planets should be visible, though note that Uranus (magnitude 5.9) and Neptune (magnitude 7.8) will be too faint for naked-eye observing and, although they're present in the lineup, will need binoculars or a telescope to spot. But Jupiter (magnitude -2), Mercury (magnitude -1), Mars (magnitude 1), and Saturn (magnitude 1) will all stand out clearly to the naked eye in a line spanning some 73 degrees on the sky.

What's more, a delicate waning crescent Moon is crashing the party as well, standing just to the lower left of Mars. Note, however, that our Moon is not perfectly in line -- that's because Luna's orbit is tilted some 5 degrees with respect to the ecliptic. The next morning, June 4, the crescent Moon does a little better, falling more closely in line a bit farther from Mars. But now Mercury has stepped out of place and stands to Jupiter's lower right (south) as the two planets reach a close conjunction just 7 degrees apart -- not to be missed, especially in binoculars or telescopes!

By June 5, Mercury lies to Jupiter's lower left, replacing the gas giant as the easternmost point in the planetary lineup. And the nearly New Moon (just 2 percent lit) stands above the pair. As June progresses, Mercury quickly ducks out of view, passing close to the Sun before reappearing in the evening sky and leaving us with only five planets in the pre-dawn sky. But those planets continue to form a nice, clean line, stretching nearly 80 degrees from Jupiter to Saturn (with Uranus, Mars, and Neptune in between) by June 30. On this morning, the Moon as rejoined the line, once again a delicate waning crescent about 33 percent lit, hanging perfectly in place to Mars' upper right.

An anonymous reader quotes a report from the New York Times: Last year, Jaume Pellicer led a team of fellow scientists into a forest on Grande Terre, an island east of Australia. They were in search of a fern called Tmesipteris oblanceolata. Standing just a few inches tall, it was not easy to find on the forest floor. "It doesn't catch the eye," said Dr. Pellicer, who works at the Botanical Institute of Barcelona in Spain. "You would probably step on it and not even realize it." The scientists eventually managed to spot the nondescript fern. When Dr. Pellicer and his colleagues studied it in the lab, they discovered it held an extraordinary secret. Tmesipteris oblanceolata has the largest known genome on Earth. As the researchers described in a study published on Friday, the fern's cells contain more than 50 times as much DNA as ours do. [The analysis revealed the species T. oblanceolata to have a record-breaking genome size of 160.45 Gbp, which is about 7% larger than that of P. japonica (148.89 Gbp). For comparison, the human genome contains about 3.1 Gbp distributed across 23 chromosomes and when stretched out like a ball of yarn, the length of DNA in each cell only measures about 2m.] "Surprisingly, having a larger genome is usually not an advantage," notes Phys.org in a report. "In the case of plants, species possessing large amounts of DNA are restricted to being slow growing perennials, are less efficient at photosynthesis (the process by which plants convert the sun's energy into sugars) and require more nutrients (especially nitrogen and phosphates) to grow and compete successfully with their smaller-genomed neighbors. In turn, such effects may influence the ability of a plant to adapt to climate change and their risk of extinction."

"In animals, some of the largest genomes include the marbled lungfish (Protopterus aethiopicus) at 129.90 Gbp and the Neuse River waterdog (Necturus lewisi) at 117.47 Gbp," reports Phys.org. "In stark contrast, six of the largest-known eukaryotic genomes are held by plants, including the European mistletoe (Viscum album) at 100.84 Gbp."

The retraction rate for European biomedical-science papers increased fourfold between 2000 and 2021, a study of thousands of retractions has found. Nature: Two-thirds of these papers were withdrawn for reasons relating to research misconduct, such as data and image manipulation or authorship fraud. These factors accounted for an increasing proportion of retractions over the roughly 20-year period, the analysis suggests. "Our findings indicate that research misconduct has become more prevalent in Europe over the last two decades," write the authors, led by Alberto RuanoâRavina, a public-health researcher at the University of Santiago de Compostela in Spain.

Other research-integrity specialists point out that retractions could be on the rise because researchers and publishers are getting better at investigating and identifying potential misconduct. There are more people working to spot errors and new digital tools to screen publications for suspicious text or data. Scholarly publishers have faced increased pressure to clear up the literature in recent years as sleuths have exposed cases of research fraud, identified when peer review has been compromised and uncovered the buying and selling of research articles. Last year saw a record 10,000 papers retracted. Although misconduct is a leading cause of retractions, it is not always responsible: some papers are retracted when authors discover honest errors in their work.

The Japanese government is pushing ahead with a plan to make Japan's publicly funded research output free to read. From a report: In June, the science ministry will assign funding to universities to build the infrastructure needed to make research papers free to read on a national scale. The move follows the ministry's announcement in February that researchers who receive government funding will be required to make their papers freely available to read on the institutional repositories from January 2025. The Japanese plan "is expected to enhance the long-term traceability of research information, facilitate secondary research and promote collaboration," says Kazuki Ide, a health-sciences and public-policy scholar at Osaka University in Suita, Japan, who has written about open access in Japan.

The nation is one of the first Asian countries to make notable advances towards making more research open access (OA) and among the first countries in the world to forge a nationwide plan for OA. The plan follows in the footsteps of the influential Plan S, introduced six years ago by a group of research funders in the United States and Europe known as cOAlition S, to accelerate the move to OA publishing. The United States also implemented an OA mandate in 2022 that requires all research funded by US taxpayers to be freely available from 2026. When the Ministry of Education, Culture, Sports, Science and Technology (MEXT) announced Japan's pivot to OA in February, it also said that it would invest around $63 million to standardize institutional repositories -- websites dedicated to hosting scientific papers, their underlying data and other materials -- ensuring that there will be a mechanism for making research in Japan open.

Long before people develop dementia, they often begin falling behind on mortgage payments, credit card bills and other financial obligations, new research shows. The New York Times: A team of economists and medical experts at the Federal Reserve Bank of New York and Georgetown University combined Medicare records with data from Equifax, the credit bureau, to study how people's borrowing behavior changed [PDF] in the years before and after a diagnosis of Alzheimer's or a similar disorder. What they found was striking: Credit scores among people who later develop dementia begin falling sharply long before their disease is formally identified. A year before diagnosis, these people were 17.2 percent more likely to be delinquent on their mortgage payments than before the onset of the disease, and 34.3 percent more likely to be delinquent on their credit card bills. The issues start even earlier: The study finds evidence of people falling behind on their debts five years before diagnosis.

"The results are striking in both their clarity and their consistency," said Carole Roan Gresenz, a Georgetown University economist who was one of the study's authors. Credit scores and delinquencies, she said, "consistently worsen over time as diagnosis approaches, and so it literally mirrors the changes in cognitive decline that we're observing." The research adds to a growing body of work documenting what many Alzheimer's patients and their families already know: Decision-making, including on financial matters, can begin to deteriorate long before a diagnosis is made or even suspected. People who are starting to experience cognitive decline may miss payments, make impulsive purchases or put money into risky investments they would not have considered before the disease.

Private-equity investors have poured billions into healthcare but often game the system, hurting both doctors and patients. From a report: Consolidation is as American as apple pie. When a business gets bigger, it forces mom-and-pop players out of the market, but it can boost profits and bring down costs, too. Think about the pros and cons of Walmart and "Every Day Low Prices." In a complex, multitrillion-dollar system like America's healthcare market, though, that principle has turned into a harmful arms race that has helped drive prices increasingly higher without improving care. Years of dealmaking has led to sprawling hospital systems, vertically integrated health insurance companies, and highly concentrated private equity-owned practices resulting in diminished competition and even the closure of vital health facilities. As this three-part Heard on the Street series will show, the rich rewards and lax oversight ultimately create pain for both patients and the doctors who treat them. Belatedly, state and federal regulators and lawmakers are zeroing in on consolidation, creating uncertainty for the investors who have long profited from the healthcare merger boom.

Consider the impact of massive private-equity investment in medical practices. When a patient with employer-based insurance goes under for surgery, the anesthesiologist's fee is supposed to be determined by market forces. But what happens if one firm quietly buys out several anesthesiologists in the same city and then hikes the price of the procedure? Such a scheme was allegedly implemented by the private-equity firm Welsh, Carson, Anderson & Stowe and the company it created in 2012, U.S. Anesthesia Partners, according to a Federal Trade Commission lawsuit filed last year. It started by buying the largest practice in Houston and then making three further acquisitions, eventually expanding into other cities throughout the state of Texas. In each location, the lawsuit alleges, USAP pursued an aggressive strategy of eliminating competitors by either acquiring them or conspiring with them to weaken competition. As one insurance executive put it in the FTC lawsuit, USAP and Welsh Carson used acquisitions to "take the highest rate of all ... and then peanut butter spread that across the entire state of Texas." In May, U.S. District Judge Kenneth Hoyt dismissed the FTC's unusual step of charging the private-equity investor, Welsh Carson, but allowed the case against USAP to proceed.

With the help of NASA's James Webb Space Telescope (JWST), an international team of astronomers discovered a galaxy at a redshift of 14.32, indicating it existed just 290 million years post-Big Bang. In a NASA release today, Stefano Carniani from Scuola Normale Superiore in Pisa, Italy, and Kevin Hainline from the University of Arizona in Tucson, Arizona, described how this source was found and what its unique properties tell us about galaxy formation: "The instruments on Webb were designed to find and understand the earliest galaxies, and in the first year of observations as part of the JWST Advanced Deep Extragalactic Survey (JADES), we found many hundreds of candidate galaxies from the first 650 million years after the big bang. In early 2023, we discovered a galaxy in our data that had strong evidence of being above a redshift of 14, which was very exciting, but there were some properties of the source that made us wary. The source was surprisingly bright, which we wouldn't expect for such a distant galaxy, and it was very close to another galaxy such that the two appeared to be part of one larger object. When we observed the source again in October 2023 as part of the JADES Origins Field, new imaging data obtained with Webb's narrower NIRCam (Near-Infrared Camera) filters pointed even more toward the high-redshift hypothesis. We knew we needed a spectrum, as whatever we would learn would be of immense scientific importance, either as a new milestone in Webb's investigation of the early universe or as a confounding oddball of a middle-aged galaxy.

In January 2024, NIRSpec observed this galaxy, JADES-GS-z14-0, for almost ten hours, and when the spectrum was first processed, there was unambiguous evidence that the galaxy was indeed at a redshift of 14.32, shattering the previous most-distant galaxy record (z = 13.2 of JADES-GS-z13-0). Seeing this spectrum was incredibly exciting for the whole team, given the mystery surrounding the source. This discovery was not just a new distance record for our team; the most important aspect of JADES-GS-z14-0 was that at this distance, we know that this galaxy must be intrinsically very luminous. From the images, the source is found to be over 1,600-light years across, proving that the light we see is coming mostly from young stars and not from emission near a growing supermassive black hole. This much starlight implies that the galaxy is several hundreds of millions of times the mass of the Sun! This raises the question: How can nature make such a bright, massive, and large galaxy in less than 300 million years?

The data reveal other important aspects of this astonishing galaxy. We see that the color of the galaxy is not as blue as it could be, indicating that some of the light is reddened by dust, even at these very early times. JADES researcher Jake Helton of Steward Observatory and the University of Arizona also identified that JADES-GS-z14-0 was detected at longer wavelengths with Webb's MIRI (Mid-Infrared Instrument), a remarkable achievement considering its distance. The MIRI observation covers wavelengths of light that were emitted in the visible-light range, which are redshifted out of reach for Webb's near-infrared instruments. Jake's analysis indicates that the brightness of the source implied by the MIRI observation is above what would be extrapolated from the measurements by the other Webb instruments, indicating the presence of strong ionized gas emission in the galaxy in the form of bright emission lines from hydrogen and oxygen. The presence of oxygen so early in the life of this galaxy is a surprise and suggests that multiple generations of very massive stars had already lived their lives before we observed the galaxy.

All of these observations, together, tell us that JADES-GS-z14-0 is not like the types of galaxies that have been predicted by theoretical models and computer simulations to exist in the very early universe. Given the observed brightness of the source, we can forecast how it might grow over cosmic time, and so far we have not found any suitable analogs from the hundreds of other galaxies we've observed at high redshift in our survey. Given the relatively small region of the sky that we searched to find JADES-GS-z14-0, its discovery has profound implications for the predicted number of bright galaxies we see in the early universe, as discussed in another concurrent JADES study (Robertson et al., recently accepted). It is likely that astronomers will find many such luminous galaxies, possibly at even earlier times, over the next decade with Webb. We're thrilled to see the extraordinary diversity of galaxies that existed at Cosmic Dawn!