Data from giant project show how withdrawn research propagates through the literature. Nature: In January, a review paper about ways to detect human illnesses by examining the eye appeared in a conference proceedings published by the Institute of Electrical and Electronics Engineers (IEEE) in New York City. But neither its authors nor its editors noticed that 60% of the papers it cited had already been retracted. The case is one of the most extreme spotted by a giant project to find papers whose results might be in question because they cite retracted or problematic research. The project's creator, computer scientist Guillaume Cabanac at the University of Toulouse in France, shared his data with Nature's news team, which analysed it to find the papers that most heavily cite retracted work yet haven't themselves been withdrawn.

"We are not accusing anybody of doing something wrong. We are just observing that in some bibliographies, the references have been retracted or withdrawn, meaning that the paper may be unreliable," Cabanac says. He calls his tool a Feet of Clay Detector, referring to an analogy, originally from the Bible, about statues or edifices that collapse because of their weak clay foundations. The IEEE paper is the second-highest on the list assembled by Nature, with 18 of the 30 studies it cites withdrawn. Its authors didn't respond to requests for comment, but IEEE integrity director Luigi Longobardi says that the publisher didn't know about the issue until Nature asked, and that it is investigating. Cabanac, a research-integrity sleuth, has already created software to flag thousands of problematic papers in the literature for issues such as computer-written text or disguised plagiarism. He hopes that his latest detector, which he has been developing over the past two years and describes this week in a Comment article in Nature, will provide another way to stop bad research propagating through the scientific literature -- some of it fake work created by 'papermill' firms.

ole_timer shares a report from Ars Technica, written by Beth Mole There's more bad news for the company behind an experimental MDMA therapy for post-traumatic stress disorder, which the Food and Drug Administration roundly rejected earlier this month. According to a report from The Wall Street Journal, the FDA is now expanding an investigation into clinical trials behind the experimental psychedelic therapy -- even though the agency has already rejected it. Agency investigators reportedly interviewed four additional people last week, asking questions regarding whether the trials underreported side effects.

People involved in the trial have previously alleged, among other things, that ill effects, such as suicidal thoughts, went undocumented, and trial participants were discouraged from reporting them to bolster the chances of FDA approval. Overall, the MDMA trials faced crushing criticism amid the FDA's review, with outside experts and agency advisers calling out allegations of sexual misconduct at one trial site, as well as flaws in overall trial designs, multiple sources of biases, and claims that the company behind the therapy, Lykos, fostered a cult-like belief in psychedelics.

According to the Journal, the recent interviews were being conducted by the FDA's Office of Regulatory Affairs, which oversees inspections, and a subdivision of that office called Biomedical Research Monitoring Program, which works to ensure the quality and integrity of data submitted to FDA. Notably, when the agency rejected MDMA, it advised Lykos to conduct a new trial. While the FDA's rejection and expanded investigation are bad enough for Lykos, the company announced this month that it's laying off 75 percent of its staff and overhauling its leadership. The moves were in response to the FDA's rejections, the company said. Additionally, a scientific journal retracted three of the company's MDMA studies, citing "protocol violations amounting to unethical conduct" in its trials, echoing claims raised amid the FDA review.

A type of genetically modified wheat developed by Argentina's Bioceres may be safely grown and bred in the United States, the U.S. Department of Agriculture said on Tuesday. From a report: Bioceres must still complete additional steps, including field trials, that will take years before it can commercialize HB4 wheat, modified to tolerate drought, industry group U.S. Wheat Associates said. Still, USDA's finding moves genetically modified wheat closer to production in the U.S. in a potential win for farmers grappling with drought and more severe weather, despite concerns among some consumers.

"Wherever wheat is grown in the world, drought takes its toll on yields and quality, so an innovation like HB4 holds a lot of interest for growers like me," said Michael Peters, an Oklahoma wheat farmer and past chairman of U.S. Wheat Associates. Genetic modification involves altering a plant's makeup by transferring DNA from one organism to another and is common in crops such as corn, used for livestock feed. Some consumer groups oppose genetic modification of wheat over concerns about human health since it is widely used to make bread and pasta, and therefore consumed directly by people. USDA's decision on HB4 wheat is farther than the agency has ever gone with genetically modified wheat, U.S. Wheat Associates said.

Amanda Smith, a 35-year-old nurse from London with Type 1 diabetes, "is at the forefront of a medical experiment that seeks to treat the root cause of diabetes by replacing the cells the disease destroys," reports Carolyn Y. Johnson for the Washington Post. "On Valentine's Day 2023, doctors transplanted replacement islet cells, grown in a lab from embryonic stem cells, into a blood vessel that feeds Smith's liver. By August, she no longer needed insulin. Her new cells were churning it out." From the report: Smith is one of a dozen patients who have received a full dose of islet cells generated in a laboratory from stem cells. Eleven of the patients in the clinical trial drastically reduced taking insulin or stopped altogether, according to data presented at an American Diabetes Association meeting in June. Despite the promise, the therapy developed by Vertex Pharmaceuticals remains in early stages, and many experts consider it a major step forward, not the finish line.

No one knows how long these cells will keep churning out insulin or whether the therapy is safe long-term until it is tested and followed up in more patients, who must take immune-suppressing drugs to prevent their body from rejecting the foreign cells. One patient died of an infection caused by a complication of sinus surgery, highlighting the risk of immunosuppressive medications, which were among the factors contributing to the patient's death. [...]

Smith credits her insulin pump with keeping her alive but was elated to banish it to the back of a kitchen cabinet. She no longer has to plan her life around her illness. "I pray this gets to everyone," Smith said. "My life has changed."

This weekend NASA said they'd turn to SpaceX to return two astronauts from the International Space Station, notes the Associated Press, "rather than risk using the Boeing Starliner capsule that delivered them." (They add that Boeing's capsule "has been plagued by problems with its propulsion system.")

But Reuters reported that even before the setback, Boeing and Lockheed Martin were "in talks to sell their rocket-launching joint venture United Launch Alliance to Sierra Space, two people familiar with the discussions said." A deal to sell ULA, a major provider of launch services to the U.S. government and a top rival to Elon Musk's SpaceX, would mark a significant shift in the U.S. space launch industry as ULA separates from two of the largest defense contractors to a smaller, privately held firm.

The potential sale comes after years of speculation about ULA's future and failed attempts to divest the joint venture over the past decade. In 2019, Boeing and Lockheed Martin reportedly explored selling ULA but couldn't agree on terms with potential buyers... Jeff Bezos' Blue Origin and Cerberus Capital Management had placed bids in early 2023 for the company, according to people familiar with the negotiations. Rocket Lab had also expressed interest, two people said. None of those discussions led to a deal...

A potential deal could accelerate deployment of [Sierra Space's] crewed spaceflight business, analysts said. A ULA acquisition, they said, would give the company in-house access to launch vehicles that could send its spaceplane and space-station components into Earth's orbit, rather than spending hundreds of millions of dollars for those launches as a customer...

ULA has faced challenges in scaling Vulcan production and upping its launch rate to meet commercial demand and fulfill contract obligations with the Space Force, which in 2021 picked Vulcan for a sizable chunk of national security missions alongside SpaceX's Falcon fleet. A sale of ULA would unshackle the company from Boeing and Lockheed, whose boards have long resisted ideas from ULA to expand the business beyond rockets and into new competitive markets such as lunar habitats or maneuverable spacecraft, according to former executives.
While Reuters's sources say the negotiations could still end without a deal, they also said ULA could be valued between $2 billion and $3 billion, giving Boeing some cash while shifting its focus to its core businesses of aerospace and defense.

Thanks to long-time Slashdot reader schwit1 for sharing the news.

America's Department of Energy has three R&D labs, according to Wikipedia, one of which is Sandia National Labs. And that New Mexico-based lab has just announced that "A milestone in quantum sensing is drawing closer, promising exquisitely accurate, GPS-free navigation." with research into "a motion sensor so precise it could minimize the nation's reliance on global positioning satellites." Until recently, such a sensor — a thousand times more sensitive than today's navigation-grade devices — would have filled a moving truck. But advancements are dramatically shrinking the size and cost of this technology. For the first time, researchers from Sandia National Laboratories have used silicon photonic microchip components to perform a quantum sensing technique called atom interferometry, an ultra-precise way of measuring acceleration. It is the latest milestone toward developing a kind of quantum compass for navigation when GPS signals are unavailable. The team published its findings and introduced a new high-performance silicon photonic modulator — a device that controls light on a microchip — as the cover story in the journal Science Advances... The new modulator is the centerpiece of a laser system on a microchip. Rugged enough to handle heavy vibrations, it would replace a conventional laser system typically the size of a refrigerator...

Besides size, cost has been a major obstacle to deploying quantum navigation devices. Every atom interferometer needs a laser system, and laser systems need modulators. "Just one full-size single-sideband modulator, a commercially available one, is more than $10,000," said Sandia scientist Jongmin Lee. Miniaturizing bulky, expensive components into silicon photonic chips helps drive down these costs. "We can make hundreds of modulators on a single 8-inch wafer and even more on a 12-inch wafer," Kodigala said. And since they can be manufactured using the same process as virtually all computer chips, "This sophisticated four-channel component, including additional custom features, can be mass-produced at a much lower cost compared to today's commercial alternatives, enabling the production of quantum inertial measurement units at a reduced cost," Lee said.

As the technology gets closer to field deployment, the team is exploring other uses beyond navigation. Researchers are investigating whether it could help locate underground cavities and resources by detecting the tiny changes these make to Earth's gravitational force. They also see potential for the optical components they invented, including the modulator, in LIDAR, quantum computing, and optical communications.
Thanks to Slashdot reader schwit1 for sharing the news.

One of Slashdot's most-visited stories of all time was the 2016 story asking: Can Cow Backpacks Reduce Global Methane Emissions? "Enteric fermentation," or livestock's digestive process, accounts for 22 percent of all U.S. methane emissions, and the manure they produce makes up eight percent more, according to the U.S. Environmental Protection Agency... Methane, like carbon, is a greenhouse gas, but methane's global warming impact per molecule is 25 times greater than carbon's, according to the EPA.
Cow methane still "heats the Earth more than every flight across the world combined," the Washington Post added today, reporting on a new $30 million genetic engineering experiment undertaken by the Innovative Genomics Institute and the University of California at Davis.

Its mission: to transform a cow's gut so it no longer releases methane. Using tools that snip and transfer DNA, researchers plan to genetically engineer microbes in the cow stomach to eliminate those emissions. If they succeed, they could wipe out the world's largest human-made source of methane and help change the trajectory of planetary warming... The average cow produces around 220 pounds of methane per year, or around half the emissions of an average car; cows are currently responsible for around 4 percent of global warming, according to the Food and Agriculture Organization...

Scientists envision a kind of probiotic pill, given to the cow at birth, that can transform its microbiome permanently...

The current project doesn't target only a particular cow species — it takes aim at the microbiome itself, offering a solution that could apply to all of them. Brad Ringeisen, executive director at the genomics institute, cut his teeth running biotechnology at the U.S. defense research agency DARPA, which helped pioneer transformative innovations including the internet, miniaturized GPS, stealth aircraft and the computer mouse. "I'm taking the DARPA mentality here," he said. "Let's solve it for all cows, not just a fraction of the cows." ...]

"There's no reason a cow has to produce methane," Ringeisen said. So what if scientists could just ... turn it off?
"I personally think this is the one that can make the biggest impact in the world," Ringeisen said. "Say you could wave a magic wand and eliminate all those emissions."

The article says that currently the scientists are feeding red-seaweed oil to a cow to measure the changes, to prepare for their final goal: "replicate those changes with gene editing." (They're using machine learning to reassemble the hundreds of pieces of each miccroorganism's DNA, so they can understand which changes they need to make with their early-intervention probiotic.) Such a probiotic could also improve a farm's productivity. Cows can lose up to 12 percent of their energy through burping up methane; other ruminants, like sheep and goats, also lose energy in this way. "If there is a way to redirect that hydrogen and convert it into milk, meat, wool — it would be much more accepted by farmers," said Ermias Kebreab [a professor of animal science at UC-Davis].

Early treatments will be tested on the cows at Davis, with researchers tracking their burps to evaluate the drop-off in methane emissions. There is still a long way to go. While scientists have proved that they can gene-edit microbes, researchers have so far only shown that they can edit a small fraction of the microbes in the cow gut — or the human gut, for that matter. Institute researchers are developing microbial gene-editing tools, even as they are mapping the species of the microbiome. They are building the plane while flying it.

The teams have received enough funding for seven years of research. The project started last year, and they hope to have a trial treatment ready for testing in cows in the next two years.

Boeing "will return its Starliner capsule from the International Space Station without the NASA astronauts," reports CNBC. Though they've been on the space station since early June, the plan is to have them stay "for about six more months before flying home in February on SpaceX's Crew-9 vehicle.

"The test flight was originally intended to last about nine days." The decision to bring Starliner back from the ISS empty marks a dramatic about-face for NASA and Boeing, as the organizations were previously adamant that the capsule was the primary choice for returning the crew. But Starliner's crew flight test, which had been seen as the final major milestone in the spacecraft's development, faced problems — most notably with its propulsion system.

"Boeing has worked very hard with NASA to get the necessary data to make this decision," NASA Administrator Bill Nelson said during a press conference with top NASA officials at Johnson Space Center in Houston on Saturday. "We want to further understand the root causes and understand the design improvements so that the Boeing Starliner will serve as an important part of our assured crew access to the ISS."

He reiterated that test flights are "neither safe, nor routine," and that the decision was the "result of a commitment to safety." NASA will now conduct another phase of its Flight Readiness Review to determine when to bring the empty Starliner home. Boeing officials had been adamant in press briefings that Starliner was safe for the astronauts to fly home in the event of an emergency, despite delaying the return multiple times. NASA said there was a "technical disagreement" between the agency and the aerospace company, and said it evaluated risk differently than Boeing for returning its crew.

Nonetheless, NASA officials repeatedly expressed support for Boeing, and Nelson said he was "100% certain" that Starliner would be able to launch with a crew again someday.
NASA posted on X.com that they'd reached the decision "after extensive review by experts across the agency.

And CNBC adds that "Ken Bowersox, NASA associate administrator, said NASA officials were unanimous in their decision to choose SpaceX to bring the crew home."

NASA's 2022 DART mission "successfully demonstrated how a fast-moving spacecraft could change an asteroid's trajectory by crashing into it," remembers Gizmodo, "potentially providing a way to defend Earth — though the asteroid in this test was never a real threat."

But a followup study suggests debris from that 525-foot (160-meter) asteroid "could actually strike back," they add, "though we're not in any danger." The [DART] team posits that the collision produced a field of rocky ejecta that could reach Earth within 10 years... [Various aerospace scientists] studied data collected by the Light Italian CubeSat for Imaging of Asteroids, or LICIACube, which observed DART's impact of Dimorphos up close. Then, they fed LICIACube's data into supercomputers at NASA's Navigation and Ancillary Information Facility to simulate how the debris from the asteroid — basically dust and rock — may have disseminated into space. The simulations tracked about 3 million particles kicked up by the impact, some of which are large enough to produce meteors that could be spotted on Earth. Particles from the impact could get to Mars in seven to 13 years, and the fastest particles could make it to our own world in just seven years.

"This detailed data will aid in the identification of DART-created meteors, enabling researchers to accurately analyze and interpret impact-related phenomena," the team wrote in the paper.
"However, these faster particles are expected to be too small to produce visible meteors, based on early observations," said Dr. Eloy Peña-Asensio, who lead the research team, in an interview with Universe Today. (He's a Research Fellow with the Deep-space Astrodynamics Research and Technology group at Milan's Polytechnic Institute.) The team's simulations indicated it could take up to 30 years before any of the ejecta is observed on Earth, in a new (and human-created) meteor shower called the Dimorphids.

So while they won't pose any risk, "If these ejected Dimorphos fragments reach Earth... their small size and high speed will cause them to disintegrate in the atmosphere, creating a beautiful luminous streak in the sky."

Under the streets of New York City, they're testing a "quantum network," reports Phys.org — where engineers from a Brooklyn company named Qunnect Inc are taking steps to "overcome the fragility of entangled states in a fiber cable and ensure the efficiency of signal delivery." For their prototype network, the Qunnect researchers used a leased 34-kilometer-long fiber circuit they called the GothamQ loop. Using polarization-entangled photons, they operated the loop for 15 continuous days, achieving an uptime of 99.84% and a compensation fidelity of 99% for entangled photon pairs transmitted at a rate of about 20,000 per second. At a half-million entangled photon pairs per second, the fidelity was still nearly 90%...

They sent 1,324 nm polarization-entangled photon pairs in quantum superpositions through the fiber, one state with both polarizations horizontal and the other with both vertical — a two-qubit configuration more generally known as a Bell state. In such a superposition, the quantum mechanical photon pairs are in both states at the same time.
"While others have transmitted entangled photons before, there has been too much noise and polarization drift in the fiber environment for entanglement to survive," the article points out, "particularly in a long-term stable network." So the Qunnect team built "automated polarization compensation" devices to correct the polarization of the entangled pairs: In their design, an infrared photon [with a wavelength of 1,324 nanometers] is entangled with a near-infrared photon of 795 nanometers. The latter photon is compatible in wavelength and bandwidth with the rubidium atomic systems, such as are used in quantum memories and quantum processors. It was found that polarization drift was both wavelength- and time-dependent, requiring Qunnect to design and build equipment for active compensation at the same wavelengths...

Qunnect's GothamQ loop demonstration was especially noteworthy for its duration, the hands-off nature of the operation time, and its uptime percentage. It showed, they wrote, "progress toward a fully automated practical entanglement network" that would be required for a quantum internet.
And Qunnect's co-founder/chief science officer says "since we finished this work, we have already made all the parts rack-mounted, so they can be used everywhere..."

Their network design and results are published in PRX Quantum.

Monday brought spectacular footage of an explosion at a UK rocket test site after an engine test went awry. The plan had been to test-fire all of a rocket stage's nine engines at the same time — they've successfully ignited them more than a hundred times — but this time one of the first eight had an "unusual" anomaly — "most likely a fire in the oxygen pump," according to a video posted by space company RFA on X.com.

The trouble "spread onto neighboring engines," eventually leading to a billowing jet of fire from the side of the vehicle. ("The engine-propellant manifold system was damaged to such a great extent that kerosene kept fueling the fire.")

Slashdot reader AleRunner writes: A rocket company has vowed to return to regular operations "as soon as possible" after an explosion during a test at the UK's new spaceport in Shetland. The explosion happened after "an "anomaly" had led to "the loss of the stage" — but there were no injuries according to a Guardian report. The test was carried out by German company Rocket Factory Augsburg which hopes to make the first UK vertical rocket launch into orbit... "We develop iteratively with an emphasis on real testing.
"This is part of our philosophy and we were aware of the higher risks attached to this approach. Our goal is to return to regular operations as soon as possible."
"In true RFA fashion, we're being as transparent as possible," the company posted Friday on X.com, "and sharing our own raw footage of the incident." The day of the explosion they'd posted that "The launch pad has been saved and is secured," and Friday posted that six-minute video explaining what happened. (It emphasizes there's an improved version of this stage that's already been built.)

The Guardian added that the explosion comes three months after RFA's successful 8-second test firing of its rocket engines — the spaceport's first rocket test.

Chinese scientists have developed a new method to produce significant quantities of water from lunar soil brought back by the Chang'e-5 mission in 2020, state broadcaster CCTV reported. The "brand-new method" involves heating moon minerals containing hydrogen to generate water vapor, which could be crucial for future lunar research stations and space exploration. Reuters reports: "After three years of in-depth research and repeated verification, a brand-new method of using lunar soil to produce large amounts of water was discovered, which is expected to provide important design basis for the construction of future lunar scientific research stations and space stations," said CCTV. The discovery could have important implications for China's decades-long project of building a permanent lunar outpost amid a U.S.-China race to find and mine the moon's resources.

Using the new method, one tonne of lunar soil will be able to produce about 51-76 kg of water, equivalent to more than a hundred 500ml bottles of water, or the daily drinking water consumption of 50 people, the state broadcaster said. China hopes that recent and future lunar expeditions will set the foundations to build the International Lunar Research Station (ILRS), an initiative it is co-leading with Russia.

Doctors have begun trialling the world's first mRNA lung cancer vaccine in patients, as experts hailed its "groundbreaking" potential to save thousands of lives. From a report: Lung cancer is the world's leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor. Now experts are testing a new jab that instructs the body to hunt down and kill cancer cells -- then prevents them ever coming back. Known as BNT116 and made by BioNTech, the vaccine is designed to treat non-small cell lung cancer (NSCLC), the most common form of the disease.

The phase 1 clinical trial, the first human study of BNT116, has launched across 34 research sites in seven countries: the UK, US, Germany, Hungary, Poland, Spain and Turkey. The UK has six sites, located in England and Wales, with the first UK patient to receive the vaccine having their initial dose on Tuesday. Overall, about 130 patients -- from early-stage before surgery or radiotherapy, to late-stage disease or recurrent cancer -- will be enrolled to have the jab alongside immunotherapy. About 20 will be from the UK. The jab uses messenger RNA (mRNA), similar to Covid-19 vaccines, and works by presenting the immune system with tumour markers from NSCLC to prime the body to fight cancer cells expressing these markers. The aim is to strengthen a person's immune response to cancer while leaving healthy cells untouched, unlike chemotherapy.

The Wow! signal, detected on August 15, 1977, was an intense radio transmission that appeared artificial and raised the possibility of extraterrestrial contact. However, recent research suggests it may have been caused by a natural astrophysical event involving a magnetar flare striking a hydrogen cloud. Universe Today reports: New research shows that the Wow! Signal has an entirely natural explanation. The research is "Arecibo Wow! I: An Astrophysical Explanation for the Wow! Signal." The lead author is Abel Mendez from the Planetary Habitability Laboratory at the University of Puerto Rico at Arecibo. It's available at the pre-print server arxiv.org. Arecibo Wow! is a new effort based on an archival study of data from the now-defunct Arecibo Radio Telescope from 2017 to 2020. The observations from Arecibo are similar to those from Big Ear but "are more sensitive, have better temporal resolution, and include polarization measurements," according to the authors. "Our latest observations, made between February and May 2020, have revealed similar narrowband signals near the hydrogen line, though less intense than the original Wow! Signal," said Mendez.

Arecibo detected signals similar to the Wow! signal but with some differences. They're far less intense and come from multiple locations. The authors say these signals are easily explained by an astrophysical phenomenon and that the original Wow! signal is, too. "We hypothesize that the Wow! Signal was caused by sudden brightening from stimulated emission of the hydrogen line due to a strong transient radiation source, such as a magnetar flare or a soft gamma repeater (SGR)," the researchers write. Those events are rare and rely on precise conditions and alignments. They can cause clouds of hydrogen to brighten considerably for seconds or even minutes.

The researchers say that what Big Ear saw in 1977 was the transient brightening of one of several H1 (neutral hydrogen) clouds in the telescope's line of sight. The 1977 signal was similar to what Arecibo saw in many respects. "The only difference between the signals observed in Arecibo and the Wow! Signal is their brightness. It is precisely the similarity between these spectra that suggests a mechanism for the origin of the mysterious signal," the authors write. These signals are rare because the spatial alignment between source, cloud, and observer is rare. The rarity of alignment explains why detections are so rare. The researchers were able to identify the clouds responsible for the signal but not the source. Their results suggest that the source is much more distant than the clouds that produce the hydrogen signal. "Given the detectability of the clouds as demonstrated in our data, this insight could enable precise location of the signal's origin and permit continuous monitoring for subsequent events," the researchers explain.

An anonymous reader quotes a report from the Associated Press: A U.S. government report expected to stir debate concluded that fluoride in drinking water at twice the recommended limit is linked with lower IQ in children. The report, based on an analysis of previously published research, marks the first time a federal agency has determined -- "with moderate confidence" -- that there is a link between higher levels of fluoride exposure and lower IQ in kids. While the report was not designed to evaluate the health effects of fluoride in drinking water alone, it is a striking acknowledgment of a potential neurological risk from high levels of fluoride. Fluoride strengthens teeth and reduces cavities by replacing minerals lost during normal wear and tear, according to the U.S. Centers for Disease Control and Prevention. The addition of low levels of fluoride to drinking water has long been considered one of the greatest public health achievements of the last century.

The long-awaited report released Wednesday comes from the National Toxicology Program, part of the Department of Health and Human Services. It summarizes a review of studies, conducted in Canada, China, India, Iran, Pakistan, and Mexico, that concludes that drinking water containing more than 1.5 milligrams of fluoride per liter is consistently associated with lower IQs in kids. The report did not try to quantify exactly how many IQ points might be lost at different levels of fluoride exposure. But some of the studies reviewed in the report suggested IQ was 2 to 5 points lower in children who'd had higher exposures.

Since 2015, federal health officials have recommended a fluoridation level of 0.7 milligrams per liter of water, and for five decades before the recommended upper range was 1.2. The World Health Organization has set a safe limit for fluoride in drinking water of 1.5. The report said that about 0.6% of the U.S. population -- about 1.9 million people -- are on water systems with naturally occurring fluoride levels of 1.5 milligrams or higher. The 324-page report did not reach a conclusion about the risks of lower levels of fluoride, saying more study is needed. It also did not answer what high levels of fluoride might do to adults.

An anonymous reader quotes a report from Ars Technica: Pong will always hold a special place in the history of gaming as one of the earliest arcade video games. Introduced in 1972, it was a table tennis game featuring very simple graphics and gameplay. In fact, it's simple enough that even non-living materials known as hydrogels can "learn" to play the game by "remembering" previous patterns of electrical stimulation, according to a new paper published in the journal Cell Reports Physical Science. "Our research shows that even very simple materials can exhibit complex, adaptive behaviors typically associated with living systems or sophisticated AI," said co-author Yoshikatsu Hayashi, a biomedical engineer at the University of Reading in the UK. "This opens up exciting possibilities for developing new types of 'smart' materials that can learn and adapt to their environment." [...]

The experimental setup was fairly simple. The researchers hooked up electroactive hydrogels to a simulated virtual environment of a Pong game using a custom-built electrode array. The games would start with the ball traveling in a random direction. The hydrogels tracked the ball's position via electrical stimulation and tracked the paddle's position by measuring the distribution of ions in the hydrogels. As the games progressed, the researchers measured how often the hydrogel managed to hit the ball with the paddle. They found that, over time, the hydrogels' accuracy improved, hitting the ball more frequently for longer rallies. They reached their maximum potential for accuracy in about 20 minutes, compared to 10 minutes for the DishBrain. The authors attribute this to the ion movement essentially mapping out a "memory" of all motion over time, exhibiting what appears to be emergent memory functions within the material itself. Perhaps the next step will be to "teach" the hydrogels how to align the paddles in such a way that the rallies go on indefinitely.

In a blog post on Wednesday, Neuralink said its second human recipient is using the brain chip to play Counter-Strike 2 and develop 3D designs in CAD software. "Alex" was given the brain chip last month to help restore his autonomy after a spinal cord injury. PCMag reports: Like the first Neuralink patient, Noland Arbaugh, Alex has also been using the brain chip to play his favorite computer games, such as Counter-Strike 2. Before, Alex had to use a mouth-operated controller, called a QuadStick, to play the first-person shooter. But even then, the controller limited him to only moving or aiming his weapon at a single time, never simultaneously like a normal Counter-Strike player. In other words, Alex had to essentially switch back and forth between the mouse and keyboard functions while playing the game. But thanks to Neuralink, he can now aim with the implant, and simultaneously move while using the QuadStick. [...]

In the blog post, Neuralink also addressed a problem the company faced when placing the chip in Arbaugh, the first patient. Despite a successful surgery, about 85% of the thread-based electrodes attached to his brain later became displaced, undermining the full potential of the chip to read neural signals. Although Arbaugh can still use his implant effectively, Neuralink wanted to avoid a repeat with Alex. In response, the company developed several "mitigations," which include reducing the chance of an air pocket forming during surgery and placing the implant deeper into the brain tissue. "Promisingly, we have observed no thread retraction in our second participant," the company said of Alex.

Whether Alex's implant outperforms the brain chip in Arbaugh was left unclear. In the meantime, Neuralink says it's working on ways to enhance the controls on the technology "to deliver full mouse and video game controller functionality." "Additionally, we plan to enable the Link [brain chip] to interact with the physical world, allowing users to feed themselves and move more independently by controlling a robotic arm or their wheelchair," the company said. You can watch Alex playing Counter-Strike 2 on YouTube.

A growing body of scientific evidence shows that microplastics are accumulating in critical human organs, including the brain, leading researchers to call for more urgent actions to rein in plastic pollution. From a report: Studies have detected tiny shards and specks of plastics in human lungs, placentas, reproductive organs, livers, kidneys, knee and elbow joints, blood vessels and bone marrow. Given the research findings, "it is now imperative to declare a global emergency" to deal with plastic pollution, said Sedat Gundogdu, who studies microplastics at Cukurova University in Turkey. Humans are exposed to microplastics -- defined as fragments smaller than 5mm in diameter -- and the chemicals used to make plastics from widespread plastic pollution in air, water and even food.

The health hazards of microplastics within the human body are not yet well-known. Recent studies are just beginning to suggest they could increase the risk of various conditions such as oxidative stress, which can lead to cell damage and inflammation, as well as cardiovascular disease. Animal studies have also linked microplastics to fertility issues, various cancers, a disrupted endocrine and immune system, and impaired learning and memory.

NASA astronauts Butch Wilmore and Suni Williams are facing challenges returning to Earth due to compatibility issues between their Boeing-designed spacesuits and SpaceX's Dragon spacecraft. Inc. Magazine reports: The space suits in question are the "intra-vehicular activity" outfits now worn by astronauts. They're simpler than the bulky extra-vehicular space suits used on space walks, and are designed to keep astronauts safe in the capsule in the very unlikely case there's a problem that causes the capsule's atmosphere to be lost. The problem is simple: Should Butch and Suni need to fly back aboard SpaceX's vehicle, their suits won't fit in Dragon's seats. [...]

Boeing and SpaceX suits evolved under totally different design sensibilities. If Boeing and NASA deem Starliner unsafe for humans to fly home in, Butch and Suni must head earthward aboard a SpaceX Dragon, but their suits won't be able to plug into Dragon's systems. Like trying to plug an essentially outdated USB A socket into an iPhone's charge port, the suit connectors have different shapes, styles, and functions. The suits themselves have different systems that integrate with their own capsules for purposes like air leak checks during pre-flight testing.

So if an emergency situation presents itself and astronauts have to come back to Earth before proper plans are finalized, Butch and Suni will have to return inside the cargo section of a Dragon space capsule "unsuited," according to NASA leadership who spoke on the matter in a press conference last week. Other plans include flying up suitable Dragon-connecting space suits for the two astronauts on a later mission, should Starliner be deemed incapable of bringing them back.

"A new front has opened in the longstanding debate over how fast the universe is expanding," writes Science magazine: For years astronomers have argued over a gulf between the expansion rate as measured from galaxies in the local universe and as calculated from studies of the cosmic microwave background (CMB), the afterglow of the Big Bang. The disparity was so large and persistent that some astronomers thought the standard theory of the universe might have to be tweaked. But over the past week, results from NASA's new James Webb Space Telescope orbiting observatory suggest the problem may be more mundane: some systematic error in the strategies used to measure the distance to nearby galaxies.

"The evidence based on these data does not suggest the need for additional physics," says Wendy Freedman of the University of Chicago, who leads [the Carnegie-Chicago Hubble Program, or CCHP] that calculated the expansion rate from JWST data using three different galactic distance measurements and released the results on the arXiv preprint server. (The papers have not yet been peer reviewed.) The methods disagreed about the expansion rate, known as the Hubble constant, or H0, and two were close to the CMB prediction.
Specifically, the team used JWST to measure the distance to 10 local galaxies using three stars with a predictable brightness: Cepheids, the brightest red giant stars, and carbon stars. Science notes that the last two methods "agreed to about 1%, but differed from the Cepheid-based distance by 2.5% to 4%." Combining all three methods the team derived a value "just shy of 70 km/s per Mpc," according to the article — leading the University of Chicago's Freedman to say "There's something systematic in the measurements. Until we can establish unambiguously where the issue lies in the nearby universe, we can't be claiming that there's additional physics in the distant universe."

But the controversy continues, according to Adam Riess of Johns Hopkins University (leader of a team of Hubble Constant researchers known as SH0ES). Riess points out that other teams have used JWST to measure distances with all three methods separately and have come up with values closer to the original SH0ES result. He also questions why CCHP excluded data from telescopes other than JWST. "I don't see a compelling justification for excluding the data they do," he says.
Thanks to long-time Slashdot reader sciencehabit for sharing the article.