Smartwatches and other wearable devices that continuously measure users' heart rates, skin temperature and other physiological markers can help spot coronavirus infections days before an individual is diagnosed. From a report: Devices like the Apple Watch, Garmin and Fitbit watches can predict whether an individual is positive for COVID-19 even before they are symptomatic or the virus is detectable by tests, according to studies from leading medical and academic institutions, including Mount Sinai Health System in New York and Stanford University in California. Experts say wearable technology could play a vital role in stemming the pandemic and other communicable diseases. Researchers at Mount Sinai found that the Apple Watch can detect subtle changes in an individual's heartbeat, which can signal that an individual has the coronavirus, up to seven days before they feel sick or infection is detected through testing. "Our goal was to use tools to identify infections at time of infection or before people knew they were sick," said Rob Hirten, assistant professor of medicine at the Icahn School of Medicine at Mount Sinai in New York City and author of the Warrior Watch study. Specifically, the study analyzed a metric called heart rate variability -- the variation in time between each heartbeat -- which is also a measure of how well a person's immune system is working.

CNN reports: According to Johns Hopkins University's tally of cases in the United States, there have been at least 23,754,315 cases of coronavirus in the U.S., and at least 395,785 deaths. On Saturday, Johns Hopkins reported 198,218 new cases and 3,286 new deaths...

On Friday, the CDC said new more contagious variants of the coronavirus will likely accelerate the spread of the virus and that means the US must double down on efforts to protect people.
The U.S. Census Bureau calculates the country's entire population is 330,827,996 people. These figures suggest 7.18% of the American population has now experienced the disease — more than 1 out of every 14 Americans.

Facebook is harnessing the power of artificial intelligence to help doctors predict whether they will need more resources, such as extra oxygen to care for COVID-19 patients in hospitals. CNET reports: The social network said Friday it developed two AI models, one based on a single chest X-ray, and another from a series X-rays, that could help forecast if a patient infected by the coronavirus is likely to get worse. A third model predicts the amount of extra oxygen a COVID-19 patient might need. Facebook's AI models generally did a better job than a human when it came to forecasting up to four days in advance if a patient will need more intensive care resources.

Partnering with with New York University Langone Health's Predictive Analytics Unit and Department of Radiology, Facebook's AI research is another example of how tech companies are trying to help the health industry battle COVID-19. [...] Facebook's models rely on a technique in which AI learns on its own rather than depending on data labelled by humans, which can be a time-consuming process. The social network and NYU are publishing their research and open sourcing the AI models.

An anonymous reader quotes a report from The Hill: A coalition of health and technology organizations are working to develop a digital COVID-19 vaccination passport to allow businesses, airlines and countries to check if people have received the vaccine. The Vaccination Credential Initiative, announced on Thursday, is formulating technology to confirm vaccinations in the likelihood that some governments will mandate people provide proof of their shots in order to enter the nation. The organization hopes the technology will allow people to "demonstrate their health status to safely return to travel, work, school and life while protecting their data privacy."

The initiative, which includes members like Microsoft, Oracle and U.S. nonprofit Mayo Clinic, is using the work from member Commons Project's international digital document that verifies a person has tested negative for COVID-19, the Financial Times reported. The Commons Project's technology, created in partnership with the Rockefeller Foundation, is being utilized by three major airline alliances. The coalition is reportedly in discussions with several governments to create a program requiring either negative tests or proof of vaccination to enter, Paul Meyer, the chief executive of The Commons Project, told the Times. The technology will need to allow patients to keep their data secure while being available in a digital wallet or a physical QR code for them to regulate who sees the information.

Razer has created a concept reusable N95 respirator called Project Hazel, featuring Chroma RGB LEDs and microphones and amplifiers to project your voice. The Verge reports: It's a concept design with a glossy outside shell made of waterproof and scratch-resistant recycled plastic, which is transparent to allow for lip-reading and seeing facial cues when you chat with people. Currently, there isn't a price or release date attached. Razer refers to Project Hazel as a surgical N95, but it hasn't yet earned any of the necessary approvals and certifications from the Food and Drug Administration, the Centers for Disease Control and Prevention, or Occupational Safety and Health Administration. In a statement to The Verge, Razer said it is working with a team of medical experts and scientists who are helping to develop the mask.

The main features of this mask lie within its two circular zones that flank your mouth. They're used for ventilation, giving the device an almost futuristic gas mask look. Razer claims Project Hazel will use active disc-type ventilators, filtering air that's breathed in, as well as the CO2 that's being exhaled. The company adds that it will be certified to filter 95 percent of airborne particles, including the COVID-19 virus and other common pathogens. [...] Microphones and amplifiers embedded in the ventilators will project your voice through the mask, so you won't have to worry about sounding muffled. Razer told us that it's working with THX sound engineers to find a balance in terms of how loud the speakers should be for accessibility purposes. [...] Each of the respirator-meets-amplifier rings can glow in the color of your choosing. And when it gets dark, a set of LEDs activate automatically to shine light on your mouth so others can still see you talk. The company also envisions that each mask will include a large charging case that sterilizes the mask with UV light when it's not in use.

According to Reuters, the CDC is expected to sign an order on Tuesday requiring nearly all international air travelers to test negative for COVID-19 within 72 hours of departure. Those under 2 and passengers connecting through the UK are exempt. From the report: The new rules are to take effect two weeks from the day they are signed by CDC Director Mark Redfield, which would be Jan. 26. The CDC has been urgently pressing for an expansion of the requirements with the Trump administration for weeks. One remaining issue is how to address some countries that have limited testing capacity and how the CDC would address travel to those countries, the sources said.

At a White House meeting on Monday, Redfield again made an urgent case to adopt the testing requirements as new strains of COVID-19 are identified in different parts of the world. He raised concerns that vaccines could potentially not be effective against new strains, sources said. U.S. officials do not plan to drop restrictions that were adopted starting in March that ban most non-U.S. citizens who have been in most of Europe, the United Kingdom and Brazil as soon as possible, the sources said. They added that public health officials are sympathetic to the push to lift the restrictions that apply only to a limited number of countries.

Slashdot reader the_newsbeagle shares an article from IEEE Spectrum: Many associate XPrize with a $10-million award offered in 1996 to motivate a breakthrough in private space flight. But the organization has since held other competitions related to exploration, ecology, and education. And in November, they launched the Pandemic Response Challenge, which will culminate in a $500,000 award to be split between two teams that not only best predict the continuing global spread of COVID-19, but also prescribe policies to curtail it...

For Phase 1, teams had to submit prediction models by 22 December... Up to 50 teams will make it to Phase 2, where they must submit a prescription model... The top two teams will split half a million dollars. The competition may not end there. Amir Banifatemi, XPrize's chief innovation and growth officer, says a third phase might test models on vaccine deployment prescriptions. And beyond the contest, some cities or countries might put some of the Phase 2 or 3 models into practice, if Banifatemi can find adventurous takers.

The organizers expect a wide variety of solutions. Banifatemi says the field includes teams from AI strongholds such as Stanford, Microsoft, MIT, Oxford, and Quebec's Mila, but one team consists of three women in Tunisia. In all, 104 teams from 28 countries have registered. "We're hoping that this competition can be a springboard for developing solutions for other really big problems as well," Miikkulainen says. Those problems include pandemics, global warming, and challenges in business, education, and healthcare. In this scenario, "humans are still in charge," he emphasizes. "They still decide what they want, and AI gives them the best alternatives from which the decision-makers choose."

But Miikkulainen hopes that data science can help humanity find its way. "Maybe in the future, it's considered irresponsible not to use AI for making these policies," he says.
For the Covid-19 competition, Banifatemi emphasized that one goal was "to make the resulting insights available freely to everyone, in an open-source manner — especially for all those communities that may not have access to data and epidemiology divisions, statisticians, or data scientists."

"As COVID-19 relentlessly infects more and more of us, scientists are getting a close look at the strange and frightening damage it can inflict on our bodies," writes Science Alert (in an article shared by long-time Slashdot reader AmiMoJo): We've known since early in the pandemic this disease wreaks havoc on more than just the respiratory system, also causing gastrointestinal conditions, heart damage and blood clotting disorders. Now, a year into the pandemic, in-depth autopsies of COVID-19 patients have revealed greater details of widespread inflammation and damage in brain tissues. This may help explain the deluge of neurological symptoms that have manifested in some patients, from headaches, memory loss, dizziness, weakness and hallucinations to more severe seizures and strokes.

Some estimate that up to 50 percent of those hospitalised with COVID-19 could have neurological symptoms that can leave people struggling to do even common daily tasks like preparing a meal. "We were completely surprised. Originally, we expected to see damage that is caused by a lack of oxygen," said physician and clinical director at National Institute of Health (NIH), Avindra Nath. "Instead, we saw multifocal areas of damage that is usually associated with strokes and neuroinflammatory diseases...."

Their report was published in the New England Journal of Medicine.
The article also remembers a September remark by a University of Liverpool neurologist to Nature magazine back in September who had also suggested possible neurological symptoms from COVID-19. "We've seen this group of younger people without conventional risk factors who are having strokes, and patients having acute changes in mental status that are not otherwise explained."

The Weather Channel reports: One main reason humans need to get a flu vaccine annually: flu strains mutate regularly so vaccines need to be slightly altered every year. During past flu seasons, the CDC has noted a vaccine effectiveness range between 40-60%, and a reduced the risk of flu-related illness by 40-60% within the overall population. There are, however, several "universal" flu vaccines currently being studied that aim to make annual flu vaccinations a thing of the past. In fact, according to the American Society for Microbiology, some of these vaccine candidates are in phase 2 and phase 3 trials right now.
Now UPI reports: Researchers believe they are one step closer to a "universal" flu vaccine, even as concerns over the seasonal virus move to the back burner during the COVID-19 pandemic. T cells found in the lungs may hold the key to long-lasting immunity against influenza A, the more common and often more severe form of the virus, according to the researchers behind a study published Friday by Science Immunology.

These cells, which the researchers call resident helper T cells, help the body initiate antiviral responses against new influenza strains even after experience with only one type of the virus, the researchers said. This type of "generalized" immune response, against all virus strains, is not possible with the currently available yearly vaccine formulations, they said.

A new study provides early evidence that a Covid-19 vaccine might be effective against two new coronavirus strains first identified in South Africa and the UK, despite a concerning mutation. CNN reports: The two strains share a mutation known as N501Y that scientists worry could allow the virus to evade the immune protection generated by a vaccine. In research posted online Thursday, scientists found that antibodies from people who had received the Pfizer/BioNTech vaccine showed "no reduction in neutralization activity" against a version of the virus that carries the N501Y mutation, which they created in the lab. In order to do this, researchers tested the virus against blood from 20 people who had received two doses of the vaccine as part of a clinical trial.

The N501Y mutation is located in the coronavirus' spike protein -- the same structure targeted by vaccines. The virus uses this protein to enter the cells it attacks. This particular mutation appears to help the virus attach to human cells, which may partly explain why these new strains appear to be more transmissible. But it is just one of many mutations in both strains that scientists have worried could make the virus less susceptible to vaccines or treatments. The study -- conducted by researchers at Pfizer and the University of Texas Medical Branch -- does not test the full array of these mutation, nor has it been peer-reviewed.

UK scientists have expressed concern that COVID-19 vaccines being rolled out in Britain may not be able to protect against a new variant of the coronavirus that emerged in South Africa and has spread internationally. From a report: Both Britain and South Africa have detected new, more transmissible variants of the COVID-19-causing virus in recent weeks that have driven a surge in cases. British Health Secretary Matt Hancock said on Monday he was now very worried about the variant identified in South Africa. Simon Clarke, an associate professor in cellular microbiology at the University of Reading, said that while both variants had some new features in common, the one found in South Africa "has a number additional mutations ... which are concerning." He said these included more extensive alterations to a key part of the virus known as the spike protein -- which the virus uses to infect human cells -- and "may make the virus less susceptible to the immune response triggered by the vaccines." Lawrence Young, a virologist and professor of molecular oncology at Warwick University, also noted that the South African variant has "multiple spike mutations."

Whole Foods CEO John Mackey says the key to keeping people healthy in the United States is for people to eat better and live healthier lives. From a report: "I mean, honestly, we talk about health care. The best solution is not to need health care," Mackey told Freakonomics Radio host Stephen Dubner in an episode. "The best solution is to change the way people eat, the way they live, the lifestyle, and diet," Mackey says. "There's no reason why people shouldn't be healthy and have a longer health span. A bunch of drugs is not going to solve the problem." Americans are not taking as good care of their own bodies as they ought to be, Mackey says: "71% of Americans are overweight and 42.5% are obese. Clearly, we're making bad choices in the way we eat," he says. "It's not a sustainable path. And so, I'm calling it out."

Haven, the joint venture formed by three of America's most powerful companies to lower costs and improve outcomes in health care, is disbanding after three years, CNBC has learned exclusively. From a report: The company began informing employees Monday that it will shut down by the end of next month, according to people with direct knowledge of the matter. Many of the Boston-based firm's 57 workers are expected to be placed at Amazon, Berkshire Hathaway or JPMorgan Chase as the firms each individually push forward in their efforts, and the three companies are still expected to collaborate informally on healthcare projects, the people said. The announcement three years ago that the CEOs of Amazon, Berkshire Hathaway and JPMorgan Chase had teamed up to tackle one of the biggest problems facing corporate America -- high and rising costs for employee health care -- sent shock waves throughout the world of medicine. Shares of healthcare companies tumbled on fears about how the combined might of leaders in technology and finance could wring costs out of the system. Brooke Thurston, a spokeswoman for Haven, confirmed the company's plans to close.

71-year-old Hugh Pickens (Slashdot reader #49,171) is a physicist who explored for oil in the Amazon jungle, commissioned microwave communications systems in Saudi Arabia, and built satellite control stations for Goddard Space Flight Center around the world including Australia, Antarctica, and Guam.

After retiring in 1999, he wrote over 1,400 Slashdot posts, and in the site's 23-year history still remains one of its two all-time most active submitters (behind only long-time Slashdot reader theodp). Today theodp shares an article by Hugh Pickens: I am a Covid Survivor," writes former Slashdot contributor extraordinaire Hugh Pickens (aka pickens, aka Hugh Pickens writes, aka Hugh Pickens DOT Com, aka HughPickens.com, aka pcol, aka ...). "I got the Covid six weeks ago and yesterday I was declared virus free. I had what was called a moderate case of Covid. I was never hospitalized. I was never in any real danger of death. But I was in bed for three weeks.

"It knocked me on my ass. I have been talking about my Covid when I go out and a lot of people are interested in what it really means to have a moderate case of Covid. I don't claim to speak for every Covid patient. I certainly can't speak for the ones who went into the hospital and are on ventilators. But I think the majority of people have a moderate case of Covid so I thought I would write this up for people that were interested."
During those three consecutive weeks in bed, "I guess I ate Jell-O for about two weeks..." Pickens writes. "I was laying in bed all day long. I was sleeping 12 to 14 hours a day..." He lost 25 pounds — and vividly describes having nightmares "every night like clockwork." But the essay ends with him committed to making the most of his second chance. "I'm only going to do what's important from now on...

"I'm 71 years old and I may have five more years or ten but I am going to live every day like it's my last."

Since 1976 "Project Censored," a U.S.-based nonprofit media watchdog organization, has been identifying "the news that didn't make the news," the most significant stories it believes are being systematically overlooked. Slashdot ran stories about its annual list of the year's most censored news stories in 1999, 2003, 2004, and in 2007, when they'd presciently warned that the media was ignoring the issue of net neutrality.

But their latest list of underreported stories includes this disturbing headline: "Antibiotic Abuse: Pharmaceutical Profiteering Accelerates Superbugs." Pharmaceutical giants Abbott and Sun Pharma are providing dangerous amounts of antibiotics to unlicensed doctors in India and incentivizing them to overprescribe. In August 2019 the Bureau of Investigative Journalism (BIJ) reported that these unethical business practices are leading to a rise in superbugs, or bacterial infections that are resistant to antibiotic treatment. Bacteria naturally evolve a resistance to antibiotics over time, but the widespread and inappropriate use of antibiotics accelerates this process. Superbugs are killing at least 58,000 babies each year and rendering a growing number of patients untreatable with all available drugs.

India's unlicensed medical practitioners, known as "quack" doctors, are being courted by Abbott and Sun Pharma, billion-dollar companies that do business in more than one hundred countries, including the United States. The incentives these companies provide to quack doctors to sell antibiotics have included free medical equipment, gift cards, televisions, travel, and cash, earning some doctors nearly a quarter of their salary. "Sales representatives would also offer extra pills or money as an incentive to buy more antibiotics, encouraging potentially dangerous overprescription," a Sun Pharma sales representative revealed to an undercover BIJ reporter... [P]atients without access to better care often turn to quack doctors for treatment, and many are unaware that their local medical "professionals" have no formal training and are being bribed to sell unnecessary antibiotics.

In September 2019, the BIJ reported on similar problems with broken healthcare systems, medical corruption, and dangerous superbugs in Cambodia. Their account describes how patients often request antibiotics for common colds, to pour onto wounds, and to feed to animals. Illegally practicing doctors and pharmacists in Cambodia admitted that they would often prescribe based on customer requests rather than appropriate medical guidelines. As the BIJ noted, "This kind of misuse speeds up the creation of drug resistant bacteria, or superbugs, which are predicted to kill 10 million people by 2050 if no action is taken...."

Although superbugs have attracted some attention, their cause and importance remain poorly understood by the public. The Independent and BuzzFlash republished the Bureau of Investigative Journalism's report; otherwise, the role of pharmaceutical companies in the rise of dangerous superbugs has been drastically underreported.
The site's list of the top 25 censored stories of 2019 - 2020 also includes:

• Growing interest in so-called "public" banks, "not legally obligated to maximize profits, as private banks are; instead, public banks are mandated to serve their communities."

• How rising sea levels and warmer waters will impact nuclear power plants, "posing increased risks of nuclear disasters."

• Proposals to revitalize journalism through public funding.

• How the U.S. military represents "a massive, hidden contributor to the climate crisis."

The New York Times reports on results from a rigorous five-year study in Trondheim, Norway that raises the question: If you increase your heart rate, will your life span follow? The study, one of the largest and longest-term experimental examinations to date of exercise and mortality, shows that older men and women who exercise in almost any fashion are relatively unlikely to die prematurely. But if some of that exercise is intense, the study also finds, the risk of early mortality declines even more, and the quality of people's lives climbs...

Their first step was to invite every septuagenarian in Trondheim to participate... More than 1,500 of the Norwegian men and women accepted... All agreed to start and continue to exercise more regularly during the upcoming five years... The first group, as a control, agreed to follow standard activity guidelines and walk or otherwise remain in motion for half an hour most days. (The scientists did not feel they could ethically ask their control group to be sedentary for five years.) Another group began exercising moderately for longer sessions of 50 minutes twice a week. And the third group started a program of twice-weekly high-intensity interval training, or HIIT, during which they cycled or jogged at a strenuous pace for four minutes, followed by four minutes of rest, with that sequence repeated four times... During that time, the scientists noted that quite a few of the participants in the control had dabbled with interval-training classes at local gyms, on their own initiative and apparently for fun...

After five years, the researchers checked death registries and found that about 4.6 per cent of all of the original volunteers had passed away during the study, a lower number than in the wider Norwegian population of 70-year-olds, indicating these active older people were, on the whole, living longer than others of their age. But they also found interesting, if slight, distinctions between the groups. The men and women in the high-intensity-intervals group were about 2 per cent less likely to have died than those in the control group, and 3 per cent less likely to die than anyone in the longer, moderate-exercise group. People in the moderate group were, in fact, more likely to have passed away than people in the control group.

The men and women in the interval group also were more fit now and reported greater gains in their quality of life than the other volunteers....

Dorthe Stensvold, a researcher at the Norwegian University of Science and Technology who led the new study, believes the study's message can be broadly applicable to almost all of us.. "Adding life to years, not only years to life, is an important aspect of healthy ageing, and the higher fitness and health-related quality of life from high-intensity interval training in this study is an important finding."

The New York Times reports: Ever since the race to develop a coronavirus vaccine began last spring, upbeat announcements were stalked by ominous polls: No matter how encouraging the news, growing numbers of people said they would refuse to get the shot... But over the past few weeks, as the vaccine went from a hypothetical to a reality, something happened. Fresh surveys show attitudes shifting and a clear majority of Americans now eager to get vaccinated. In polls by Gallup, the Kaiser Family Foundation and the Pew Research Center, the portion of people saying they are now likely or certain to take the vaccine has grown from about 50 per cent this summer to more than 60 per cent, and in one poll 73 per cent — a figure that approaches what some public health experts say would be sufficient for herd immunity...

[T]he attitude improvement is striking. A similar shift on another heated pandemic issue was reflected in a different Kaiser poll this month. It found that nearly 75 per cent of Americans are now wearing masks when they leave their homes.

The change reflects a constellation of recent events: the uncoupling of the vaccine from Election Day; clinical trial results showing about 95 per cent efficacy and relatively modest side effects for the vaccines made by Pfizer-BioNTech and Moderna; and the alarming surge in new coronavirus infections and deaths... The lure of the vaccines' modest quantities also can't be underestimated as a driver of desire, somewhat like the must-have frenzy generated by a limited-edition Christmas gift, according to public opinion experts... A barrage of feel-good media coverage, including rapt attention given to leading scientists and politicians when they get jabbed and joyous scrums surrounding local health care workers who become the first to be vaccinated, has amplified the excitement, public opinion experts say.

Reuters notes the "miraculous speed" of mRNA vaccines, while also calling it "a glimpse of what's possible if it can be applied post-pandemic to treat cancer or rare diseases."

The vaccine market alone is worth about $35 billion each year, and investors apparently believe mRNA companies will capture around two-third of that, leading market researcher Bernstein to evalaute the combined worth of mRNA companies at nearly $180 billion. The technology is the closest thing yet to making medicine digital. MRNA vaccines essentially inject genetic code that instructs a recipients' cells to construct a part of the virus. The body recognizes the produced protein as foreign and mounts a future immune response when exposed. Moderna and BioNTech's vaccines show the technology works fast. Vaccines typically take a decade to develop. They took less than a year...

The speed of mRNA therapeutics is a big advantage. For example, flu vaccines only reduce the risk of illness by up to 60% because makers must guess which strains will be prevalent each season. Sometimes they're wrong. Shaving months off means better guesses, and higher efficacy.

The bigger opportunity comes from the validation of the mRNA "platform". Instructing cells to produce desired proteins could lead to multiple advances. Perhaps they can instruct the body to more vigorously attack cancerous cells or repair damaged tissue. Producing missing proteins might fight inherited diseases...

Success against Covid-19 means these companies will be flush with cash from sales and attract partnerships and scientific talent. That should make 2021 a watershed.

An anonymous reader shares a feature report: At the end of 2019, before the coronavirus pandemic started, the two best-known faces of the pharmaceutical business were the imprisoned Martin Shkreli and the lawsuit-laden opioid makers at Purdue Pharma. The rest of the industry was perhaps best known for the skyrocketing prices of its medicines. In a Gallup Poll of the public's view of various business sectors, pharma was ranked at the bottom, behind the oil industry, advertising and public relations, and lawyers. Who'd have guessed that a year later pharma would be getting credit for saving the world?

From cruise lines to meatpackers, business will have plenty to answer for in its handling of the pandemic, but this part of it worked. The Covid-19 vaccines developed by the drug industry, in partnership with governments, will almost certainly prevent hundreds of thousands of American deaths and millions more around the world. They will revive trillions of dollars in economic activity, let grandparents see grandchildren, and finally bring an end to a year that has -- sing it together one last time as the ball drops over an empty Times Square -- really sucked. In a time where almost everything else went wrong, the vaccine effort was something that went (mostly) right.

Pfizer and partner BioNTech agreed to supply an additional 100 million doses of their Covid-19 vaccine to the U.S., as the country seeks to widen its immunization program and revive its economy. From a report: The agreement brings the total number of doses to be delivered to the U.S. to 200 million, the companies said Wednesday in a statement. The drugmaker expects to deliver all the doses to U.S. vaccine and drug accelerator Operation Warp Speed by July 31. Countries around the world are seeking supplies of vaccine they hope will allow the reopening of schools and businesses and the resumption of travel. The U.K. has also begun administering doses of the Pfizer-BioNTech shot, and European drug authorities cleared it for use on Monday.

The U.S. has been working to expand supplies of the front-runner vaccine, in light of the drugmakers' commitments to other countries. Earlier this month, the U.S. exercised an option to buy 100 million additional vaccine doses from Moderna, doubling the number it has on order from that company to 200 million. Like Pfizer and BioNTech's vaccine, Moderna's is a two-shot regimen based on new technology known as messenger RNA, but it doesn't have to be stored at the same ultracold temperatures as the Pfizer-BioNTech shot.