Medicine

Bill Gates Gives TED Talk Proposing New Global Team to Quickly Prevent Epidemics (youtube.com) 118

Bill Gates shares a statistic about the COVID-19 pandemic. "If we'd been able to stop it within 100 days, we would've saved over 98% of the lives." "Viruses spread exponentially, and so if you get in there when the infection rate is fairly small, you can actually stop the spread."
In a new TED talk, Gates argues that we did learn a lot from this pandemic — enough to build a prevention system for next time. "Covid 19 can be the last pandemic if we take the right steps." But the answer isn't vaccines. "We also need vaccines, but we want to stop the outbreak before we have to do a global vaccination campaign." And then Gates points out that currently it could take months to get resources to a low-income country experiencing an outbreak.

Read on for Slashdot's report on Gates' proposed solution — and how he feels about his own prominence in anti-vaccine misinformation.
Space

The Case for Exploring the Planet Uranus (bgr.com) 72

Once every 10 years there's a report released by America's National Academies of Sciences, Engineering, and Medicine.

Released this year, the report recommends prioritizing a mission to the planet Uranus to map its gravitational and magnetic fields and study how the planet's internal heat moves to the surface.

BGR reports: Despite being the seventh planet in our solar system, there's very little we know about Uranus as a whole. In fact, one of the best images we have of the planet was captured in 1986 by the Voyager 2... Additionally, scientists want to learn more about the various moons that surround the planet. We also know very little about the ring system that surrounds the blue planet. A team led by Mark Hofstadter, a planetary scientist with NASA's Jet Propulsion Lab wrote a white paper on their goals....

We currently already have the tech we need to get a spacecraft there that can orbit the planet. Additionally, scientists have found that launching a mission in 2031 would allow us to capitalize on gravity assistance from Jupiter.

The report also recommends studying Enceladus, an icy moon orbiting Saturn which has shown signs it could sustain microbial life.

Thanks to Slashdot reader alaskana98 for submitting the story.
Medicine

Study Finds New Clues About Causes of Cancer (theguardian.com) 15

Analysis of thousands of tumours has unveiled a treasure trove of clues about the causes of cancer, representing a significant step towards the personalisation of treatment. The Guardian: Researchers say that for the first time it is possible to detect patterns -- called mutational signatures -- in the DNA of cancers. These provide clues including about whether a patient has had past exposure to environmental causes of cancer such as smoking or UV light, for example. This is important as these signatures allow doctors to look at each patient's tumour and match it to specific treatments and medications. However, these patterns can be detected only through analysis of the vast amounts of data unearthed by whole genome sequencing -- identifying the genetic makeup of a cell.
China

Shanghai's Low Covid Death Toll Revives Questions About China's Numbers (nytimes.com) 185

China's largest city has recorded just 17 Covid deaths, despite surging cases. How China defines a Covid death may be part of the reason. The New York Times: By the numbers, Shanghai has been an exemplar of how to save lives during a pandemic. Despite the city's more than 400,000 Covid-19 infections, just 17 people have died, according to officials, statistics they have touted as proof that their strategy of strict lockdowns and mass quarantines works. But those numbers may not give a complete picture of the outbreak's toll. China typically classifies Covid-related deaths more narrowly than many other countries, labeling some chronically ill patients who die while infected as victims of those other conditions. In addition, a nearly three-week lockdown of China's biggest city has limited access to medicine and care for other illnesses. A nurse who suffered an asthma attack died after being denied care because of virus controls. A 90-year-old man died of complications from diabetes after being turned away from an overwhelmed hospital.

"If, at the time, he had been able to get treatment, he probably would have survived," said the man's granddaughter, Tracy Tang, a 32-year-old marketing manager. Residents and frontline workers have also been pushed to their limits by the policies. A hospital worker started bleeding internally after long hours conducting mass testing; she, too, died. It may never become clear how many similar stories there are. China does not release information on excess deaths, defined as the number of deaths -- from Covid as well as other causes -- exceeding the expected total in a given period. Public health scholars say that figure more accurately captures losses during the pandemic, as countries define Covid-related deaths differently. But as an example of the hidden impacts, a prominent Chinese physician recently estimated that nearly 1,000 more diabetes patients could die than expected during Shanghai's lockdown, urging the authorities to take a more measured response.

The outbreak there has revived questions about the true toll of Covid in China, which has officially reported fewer than 5,000 deaths from the coronavirus in two years. Beijing is unlikely to waver from its stringent approach. China's leader, Xi Jinping, has made the country's low death and infection rates central to his administration's legitimacy. Officials have been fired after even a few cases were detected in their jurisdictions. Last week, Mr. Xi said that "prevention and control work cannot be relaxed." The focus on minimizing Covid deaths risks incentivizing officials to neglect other causes of death, said Xi Chen, a professor of public health at Yale.

Medicine

Bill Gates Urges Investing in Faster Development for Life-Saving Drugs (nytimes.com) 58

The Covid-19 pandemic "would look very different if scientists had been able to develop a treatment sooner," writes Bill Gates, in a guest essay Friday in the New York Times. This ultimately would've reduced fatalities — "and it may have been harder for myths and misinformation to spread the way they did."

But note that Gates said "treatment" — not vaccine. Gates believes most people in the public health community had expected an effective treatment would appear before vaccines became available. Unfortunately, that's not what happened. Safe, effective Covid vaccines were available within a year — a historic feat — but treatments that could keep large numbers of people out of the hospital were surprisingly slow out of the gate....

In late 2021, a few of their efforts paid off — not as soon as would have been ideal, but still in time to have a big impact. Merck and its partners developed an antiviral called molnupiravir, which was shown to significantly reduce the risk of hospitalization or death for people at high risk. Soon after, another oral antiviral, Paxlovid, made by Pfizer, also proved to be very effective, reducing the risk of severe illness or death by nearly 90 percent among high-risk, unvaccinated adults. These drugs are useful tools for combating the pandemic, but they arrived much later than they should have and, for many, they are still difficult to access....

It's a mistake to think of vaccines as the star of the show and therapeutics as the opening act you would just as soon skip. We're lucky that scientists made Covid vaccines as quickly as they did — if they hadn't, the death toll would be far worse. But in the event of another pandemic, even if the world is able to develop a vaccine for a new pathogen in 100 days, it will still take a long time to get the vaccine to most of the population.... With good therapeutics, the risk of severe illness and death could drop significantly, and countries could decide to loosen restrictions on schools and businesses, reducing the disruption to education and the economy. What's more, imagine how people's lives would change if we're able to take the next step by linking testing and treatment. Anyone with early symptoms that might indicate Covid (or any other viral disease) could walk into a pharmacy or clinic anywhere in the world, get tested and, if positive for the virus, walk out with antivirals to take at home....

In short, although therapeutics didn't rescue us from Covid, they hold a lot of promise for saving lives and preventing future outbreaks from crippling health systems. But to make the most of that promise, the world needs to invest in the research and systems we'll need to find treatments much faster. That's why my foundation has supported a therapeutics accelerator at Duke University, but broader initiatives will be necessary to make lasting change. This will require substantial investment to bring together academia, industry and the latest software tools. But if we succeed, the next time the world faces an outbreak, we'll save millions more lives.

Gates offers several specific recommendations — including "investing in large libraries of drug compounds that researchers can quickly scan to see whether existing therapies work against new pathogens." And... With advances in artificial intelligence and machine learning, it's now possible to use computers to identify weak spots on pathogens that we already know about, and we'll be able to do the same when new pathogens arise. These technologies are also speeding up the search for new compounds that will attack those weak spots. With adequate funding, various groups could take the most promising new compounds through Phase 1 studies even before there's an epidemic, or at least have several leads that can be turned into a product quickly once we know what the target looks like.
Medicine

Researchers Rejuvenate Skin Cells of 53-Year-Old Woman To the Equivalent of a 23-Year-Old's (bbc.com) 63

An anonymous reader quotes a report from the BBC: Researchers have rejuvenated a 53-year-old woman's skin cells so they are the equivalent of a 23-year-old's. [...] The scientists in Cambridge believe that they can do the same thing with other tissues in the body. The head of the team, Prof Wolf Reik, of the Babraham Institute in Cambridge, told BBC News that he hoped that the technique could eventually be used to keep people healthier for longer as they grow older. [...] Prof Reich stressed though that the work, which has been published in the journal eLife, was at a very early stage. He said that there were several scientific issues to overcome before it could move out of his lab and into the clinic. But he said that demonstrating for the first time that cell rejuvenation is possible was a critical step forward.

Prof Reik's team used [a method, called iPS, that involves adding chemicals to adult cells to turn them into stem cells] on 53-year-old skin cells. But they cut short the chemical bath from 50 days to around 12. Dr Dilgeet Gill was astonished to find that the cells had not turned into embryonic stem cells -- but had rejuvenated into skin cells that looked and behaved as if they came from a 23-year old. He said: "I remember the day I got the results back and I didn't quite believe that some of the cells were 30 years younger than they were supposed to be. It was a very exciting day!"

The technique cannot immediately be translated to the clinic because the iPS method increases the risk of cancers. But Prof Reik was confident that now it was known that it is possible to rejuvenate cells, his team could find an alternative, safer method. "The long-term aim is to extend the human health span, rather than the lifespan, so that people can get older in a healthier way," he said. Prof Reik says some of the first applications could be to develop medicines to rejuvenate skin in older people in parts of the body where they have been cut or burned -- as a way to speed up healing. The researchers have demonstrated that this is possible in principle by showing that their rejuvenated skin cells move more quickly in experiments simulating a wound. The next step is to see if the technology will work on other tissues such as muscle, liver and blood cells.

Medicine

MS Symptoms May Have Been 'Reversed' In Immunotherapy Breakthrough (iflscience.com) 31

A new immunotherapy that targets cells infected with Epstein-Barr Virus (EBV) has halted the progression of multiple sclerosis (MS) in a small trial. Perhaps even more incredibly, in some patients, it is possible that symptoms of MS were actually reversed, though this was not fully identified in the most recent presentation of results (PDF). IFLScience reports: [S]ignificant evidence has linked infection of EBV and the eventual development of MS. [...] Attempting to "transform treatment of Multiple Sclerosis," Atara Biotherapeutics has developed an allogeneic T-cell therapy called ATA188. The concept is simple -- when cells are infected with EBV, they express small proteins called antigens on the cell surface, and the immunotherapy contains immune cells that target and destroy them.

In a trial of 24 patients who received the therapy, 20 saw improvements or stability in their symptoms and no fatal or serious adverse effects were reported. Early brain scans suggest that some damaged nerve cells may have been "repaired" by the therapy in a process called remyelination, which could mean a reversal of damage caused by MS in the nervous system, but this has not yet been confirmed. While the results are extremely promising, it is an early Phase 1 trial with a small sample size and no placebo or control group, so it is unclear whether the results are significant at this stage. However, it is unlikely that this repair would occur naturally, suggesting the therapy is having a beneficial effect on some level.

Medicine

Researchers Create Bacteria That Could Protect Your Gut From Antibiotics (engadget.com) 36

In a new study published in the journal Nature Biomedical Engineering, researchers from Harvard and MIT detail work they've done on a "living cellular therapeutic device" that promises to protect humans from the harmful side effects antibiotics can have on our guts. Engadget reports: Per Science Daily, they modified a strain of bacteria that is frequently used in cheese production to deliver an enzyme that can break down beta-lactam antibiotics. Many of the most commonly prescribed antibiotics in the US, including penicillin, fall under that family. Using gene editing, they further modified how their bacterium synthesizes the enzyme to prevent it from transferring that capability to other bacteria. The result is a treatment that reduces the harmful effects of antibiotics while still allowing those drugs to do their work.

In a study involving mice, the researchers found their bacteria "significantly" reduced the damage ampicillin did to the test subject's gut microbes and allowed those communities to recover fully after just three days. By contrast, in mice that only received the antibiotic, the researchers saw a much greater loss of microbial diversity. "We are now focusing on getting these living therapies to patients and are finalizing the design of an effective, short, and inexpensive clinical trial," said Andres Cubillos-Ruiz, the lead author of the study.

Businesses

Amazon Workers Made Up Almost Half of All Warehouse Injuries Last Year (theverge.com) 60

Amazon workers only make up a third of US warehouse employees, but in 2021, they suffered 49 percent of the injuries for the entire warehouse industry, according to a report by advocacy group Strategic Organizing Center (or SOC). The Verge reports: After analyzing data from the Occupational Safety and Health Administration (OSHA), the union coalition found that Amazon workers are twice as likely to be seriously injured than people who work in warehouses for other companies. The report considers "serious injuries" to be ones where workers either have to take time off to recover or have their workloads reduced, following OSHA's report classification (pdf) of "cases with days away from work" and "cases with job transfer or restriction." The data shows that, over time, the company has been shifting more toward putting people on light duty, rather than having them take time off. The report authors also note that Amazon workers take longer to recover from injuries than employees at other companies: around 62 days on average, versus 44 across the industry.

Amazon employees have said it's not the work itself that's particularly dangerous but rather the grueling pace the company's automated systems demand. Amazon actually had workers go slower in 2020 to help combat COVID-19, which accounts for the notably lower injury rates that year. But, as the report notes, the injuries increased by around 20 percent between 2020 and 2021 as the company resumed its usual pace -- though the injury rates for 2021 were still lower than they were in 2019. [...] Unfortunately, this study's results tell the same story we've been hearing for years. Even with its reduced injury rates in 2020, Amazon workers were still hurt twice as often as other warehouse workers, according to SOC.
Further reading: Amazon Workers At 100 More Facilities Want To Unionize (Yahoo Finance)
Medicine

Apple Targets Watch Blood-Pressure Tool for 2024 After Snags (bloomberg.com) 33

Apple's plan to add a highly anticipated blood-pressure monitor to its smartwatch has hit some snags and the technology isn't expected to be ready until 2024 at the earliest, Bloomberg reported Tuesday, citing people with knowledge of the matter. From the report: The company has teams working on an updated sensor and software for the Apple Watch that would determine if a user has high blood pressure, but accuracy has been a challenge during testing, said the people, who asked not to be identified because the matter is private. The feature has been planned for at least four years, but it's probably two years away from hitting the market and may slip until 2025, they said. Apple's shares were up about 1% at 9:41 a.m. in New York. Blood-pressure features may become a key selling point for smartwatches in coming years, but the technology hasn't been easy to master. Though Apple rivals such as Samsung have launched watches with the capability, they require monthly calibration with a traditional monitor. Last year, Alphabet-owned Fitbit launched a public study to test wrist-based blood-pressure measurement.
Medicine

Psilocybin Frees Up Depressed Brain, Study Shows (bbc.com) 97

Psilocybin, a drug found in magic mushrooms, appears to free up the brains of people with severe depression in a way that other antidepressants do not, a study has found. The BBC reports: The results, based on brain scans of 60 people, mean the drug could treat depression in a unique way, the researchers say. Patients with depression are warned not to take psilocybin on their own. A synthetic form of the drug is tested on people in trials under strict medical conditions, with psychological support from experts provided before, during and after it is taken.

With depression, the brain can get stuck in a rut and locked into a particular negative way of thinking, he said. But when given psilocybin, people's brains opened up and became "more flexible and fluid" up to three weeks later. This could be seen in increased connections between regions of the brain when patients were scanned. These patients were more likely to experience an improvement in mood months later. Similar changes were not seen in the brains of people treated with a standard antidepressant.

The results, published in Nature Medicine, are taken from two studies. In the first, everyone received psilocybin; and in the second -- a randomized controlled trial - some were given the drug while others were given a different antidepressant. All participants also received talking therapies with registered mental health professionals. Brain scans were taken before, and then one day or three weeks after taking the therapy.

Medicine

Incomplete Data May Mask an Increase in US Covid Cases, But Infection Counts De-Emphasized (nbcnews.com) 140

"At first glance, U.S. Covid cases appear to have plateaued over the last two weeks," reports NBC News, "with a consistent average of around 30,000 per day..."

"But disease experts say incomplete data likely masks an upward trend." "I do think we are in the middle of a surge, the magnitude of which I can't tell you," Zeke Emanuel, vice provost of global initiatives at the University of Pennsylvania, said. The BA.2 omicron subvariant, which now accounts for about 72 percent of U.S. cases and is more contagious than the original omicron variant, is fueling that spread, Emanuel added. "It's much more transmissible. It's around. We just don't have a lot of case counts," he said.

Emanuel and other experts cite a lack of testing as the primary reason cases are underreported. At the height of the omicron wave in January, the U.S. was administering more than 2 million tests per day. That had dropped to an average of about 530,000 as of Monday, the most recent data from the Centers for Disease Control and Prevention. "The milder symptoms become, the less likely people are to test or show up in official case counts," said David Dowdy, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health. More people also now have access to at-home rapid tests that are free or covered by insurance, and most of those test results don't get reported to state health departments or the CDC.

"Case counts and testing are progressively becoming shaky indicators because we're not catching everyone in the system," said Dr. Jonathan Quick, an adjunct professor at the Duke Global Health Institute.

Some local data, however, does reveal recent spikes. Average Covid cases have risen nearly 80 percent in Nebraska, 75 percent in Arizona, 58 percent in New York and 55 percent in Massachusetts over the last two weeks. Wastewater surveillance similarly suggests that infections are rising in Colorado, Ohio and Washington, among other states.

The Johns Hopkins epidemiologist emphasized that hospitalization figures are more important than case counts.

"If we're seeing an increase in cases, but not an increase in severe cases, I think it's a very valid question of does that matter?"
Medicine

VR Role-Play Therapy Helps People With Agoraphobia, Finds Study 18

An anonymous reader quotes a report from the Guardian: It's a sunny day on a city street as a green bus pulls up by the kerb. Onboard, a handful of passengers sit stony-faced as you step up to present your pass. But you cannot see your body -- only a floating pair of blue hands. It might sound like a bizarre dream, but the scenario is part of a virtual reality (VR) system designed to help people with agoraphobia -- those for whom certain environments, situations and interactions can cause intense fear and distress. Scientists say the approach enables participants to build confidence and ease their fears, helping them to undertake tasks in real life that they had previously avoided. The study also found those with more severe psychological problems benefited the most. "It leads to a real step-change in people's lives," said Prof Daniel Freeman, the lead researcher in the work, from the psychiatry department at the University of Oxford.

The VR experience begins in a virtual therapist's office before moving to scenarios such as opening the front door or being in a doctor's surgery, each with varying levels of difficulty. Participants are asked to complete certain tasks, such as asking for a cup of coffee, and are encouraged to make eye contact or move closer to other characters. Freeman said while the scenarios feel real, the computer-generated scenes allow participants to feel able to try something new or approach the situation differently. "There's a little bit of the conscious bit [of the brain] going: 'OK, it's OK, I know it's not real and therefore I can persist, try something new and do something differently,'" he said. "That enables people to apply it in the real world. Basically, if you get over something in VR, you will get over in the real world."

Writing in the Lancet Psychiatry journal, Freeman and colleagues report how they randomly allocated 174 patients with difficulties going outside and psychosis to use the "gameChange" VR technology alongside their usual care. Another 172 patients were allocated to receive their usual care alone. [...] The results show that six weeks after the trial began, those allocated to the VR therapy had a small but significant reduction in avoiding real-life situations because of agoraphobia, as well as less distress, compared with those who had only received their usual care. However, by six months there was no difference between the two groups. But further analysis revealed that those who had severe agoraphobia benefited most, and for these people the effect was sustained at six months. Such patients were able to complete, on average, two more activities than before -- such as going shopping or getting on a bus.
Medicine

Diabetes Successfully Treated Using Ultrasound In Preclinical Study (newatlas.com) 63

Across three different animal models researchers have demonstrated how short bursts of ultrasound targeted at specific clusters of nerves in the liver can effectively lower insulin and glucose levels. New Atlas reports: Reporting in the journal Nature Biomedical Engineering, a team led by GE Research, including investigators from the Yale School of Medicine, UCLA, and the Feinstein Institutes for Medical Research, demonstrated a unique non-invasive ultrasound method designed to stimulate specific sensory nerves in the liver. The technology is called peripheral focused ultrasound stimulation (pFUS) and it allows highly targeted ultrasound pulses to be directed at specific tissue containing nerve endings. "We used this technique to explore stimulation of an area of the liver called the porta hepatis," the researchers explained in a Nature briefing. "This region contains the hepatoportal nerve plexus, which communicates information on glucose and nutrient status to the brain but has been difficult to study as its nerve structures are too small to separately stimulate with implanted electrodes."

The newly published study indicates short targeted bursts of pFUS at this area of the liver successfully reversed the onset of hyperglycaemia. The treatment was found to be effective in three separate animal models of diabetes: mice, rats and pigs. [...] The study found just three minutes of focused ultrasound each day was enough to maintain normal blood glucose levels in the diabetic animals. Studies in humans are currently underway to work out whether this method translates from animal studies. But there are other hurdles facing broad clinical deployment of the technique beyond simply proving it works. Current ultrasound tools used to perform this kind of pFUS technique require trained technicians. The researchers suggest the technology exists to simplify and automate these systems in a way that could be used by patients at home, but it will need to be developed before this treatment can be widely deployed.

Biotech

New Blood Test Predicts Risk of Heart Attack, Stroke With Twice Previous Accuracy (theguardian.com) 51

An anonymous reader quotes a report from the Guardian: Scientists have developed a blood test that can predict whether someone is at high risk of a heart attack, stroke, heart failure or dying from one of these conditions within the next four years. The test, which relies of measurements of proteins in the blood, has roughly twice the accuracy of existing risk scores. It could enable doctors to determine whether patients' existing medications are working or whether they need additional drugs to reduce their risk. It could also be used to hasten the development of new cardiovascular drugs by providing a faster means of assessing whether drug candidates are working during clinical trials. The test is already being used in four healthcare systems within the US and [...] it could be introduced to the UK in the near future.

[Researchers] used machine learning to analyze 5,000 proteins in blood plasma samples from 22,849 people and identify a signature of 27 proteins that could predict the four-year likelihood of heart attack, stroke, heart failure or death. When validated in 11,609 individuals, they found their model was roughly twice as good as existing risk scores, which use a person's age, sex, race, medical history, cholesterol and blood pressure to assess their likelihood of having a cardiovascular event. The results were published in Science Translational Medicine. Importantly, the test can also accurately assess risk in people who have previously had a heart attack or stroke, or have additional illnesses, and are taking drugs to reduce their risk, which is where existing risk prediction scores tend to fall down.

Medicine

India Reports First Case of Highly Transmissible XE Variant (bloomberg.com) 64

Mumbai's city administration reported India's first case of the highly-transmissible coronavirus variant, XE, on Wednesday. From a report: The hybrid of two omicron strains BA.1 and BA.2 was detected in a 50-year-old woman who had traveled to the city from South Africa in February, the Brihanmumbai Municipal Corporation said in a statement. The asymptomatic patient had no cormorbidities and had been quarantined after being diagnosed almost a month later in March, the BMC said. The hybrid strain, which was first detected in the U.K., could be the most transmissible variant yet, according to the World Health Organization.
Medicine

$4 billion Health Tech Startup Olive Overpromises and Underdelivers (axios.com) 24

Olive is the buzzy startup whose purple "go save health care" buses dominate industry conferences. But its promises to save health systems millions of dollars with its automation software don't deliver. Axios reports: An Axios investigation finds that Olive relies on rough estimations for its calculations, inflates its capabilities and, in many cases, generates only a fraction of the savings it pledges. Erin's reporting includes interviews with 16 people, including former and current employees and health tech executives.

Valued at $4 billion by firms like Tiger Global and Vista Equity Partners, Olive is the highest-profile startup in health care automation; a holy grail that promises to cut costs and direct more time toward patient care. In just 10 years, Olive's promise to reduce its clients' administrative spending by roughly 5X the cost of installing the software has garnered the attention of some of the largest health systems in the U.S. Axios' reporting, which includes interviews with 16 people -- including former and current employees, health tech executives and others -- finds Olive is failing to deliver on those promises.

Medicine

7,000 Steps Can Save Your Life (axios.com) 68

Mortality risk was reduced by 50% for older adults who increased their daily steps from around 3,000 to around 7,000, according to new medical research. Axios reports: 7,000 is the new 10,000, in terms of steps you should shoot for, The Lancet medical journal reports. This is all it takes for those 60 and older to dramatically increase their lifespans. Even for younger adults, the benefits of daily walking actually level off around 9,000 steps per day, not 10,000, the researchers found. The risk reduction plateaued beyond that number.

"Walking benefits nearly every cell in the body," says Amanda Paluch, a kinesiologist and public health expert at UMass Amherst and the lead author of the study. It's wildly effective. Walking strengthens your heart, improves bone density, relaxes your mind, and helps with muscle-building and pain management. Almost everyone can do it anywhere: your house, the office, outside. Start with 30 minutes and work your way up."It's not an all or nothing situation," says Paluch. Even just boosting daily step count to 5,000 -- for 60 and older -- and 7,000 -- for younger folks -- slashed mortality risk by 40%.

Medicine

Alzheimer's Study Finds 42 More Genes Linked To Higher Risk of Disease (theguardian.com) 28

An anonymous reader quotes a report from the Guardian: The largest genetic study of Alzheimer's to date has provided compelling evidence linking the disease to disruption in the brain's immune system. The study, using the genomes of 100,000 people with Alzheimer's and 600,000 healthy people, identified 75 genes linked to an increased risk of the disease, including 42 that had not previously been implicated. The findings suggest degeneration in the brains of dementia patients could be spurred on by "over-aggressive" activity in the brain's immune cells, called microglia.

The study, the largest of its kind to date, also allowed scientists to devise a genetic risk score that could predict which patients with cognitive impairment would, within three years of first showing symptoms, go on to develop Alzheimer's. The score is not intended for clinical use at the moment, but could be used when recruiting people for clinical trials of drugs aimed at treating the disease in the earliest stages. The latest work highlights different sets of genes seen in more common forms of Alzheimer's, including a role for the immune system. "If [at the outset] we'd seen the genetics of common disease, we would've said this is an immune disease," said professor Julie Williams, the director of the UK Dementia Research Institute at Cardiff University and a co-author of the study. "It's not the same disease."

Risk genes highlighted in the study include ones that affect how efficiently the brain's immune cells, microglia, clear away tissue that is distressed. In people at risk, these housekeeper cells appeared to be working too aggressively. A similar pattern was found for genes that control how readily synapses, which connect neurons, send out an "eat me" signal when in distress. The high-risk variants appeared to lower the threshold for synapses sending out distress signals, causing the brain to purge connections at a quicker rate. The findings, published in the journal Nature Genetics, fit with previous results pointing to a role for the immune system. People with diabetes, which affects the immune system, are at considerably higher risk, for instance, and once dementia has been diagnosed infections can trigger more rapid cognitive decline.

Biotech

This Snakelike Robot Slithers Down Your Lungs and Could Spot Cancer (msn.com) 28

"Researchers in the United Kingdom have developed an autonomous, snakelike robot designed to slither down human lungs into places that are difficult for medical professionals to reach," reports the Washington Post.

The tool "could improve the detection and treatment of lung cancer and other pulmonary diseases." In a medical paper released in the journal of Soft Robotics last week, scientists from the University of Leeds unveiled a new "magnetic tentacle robot," which is composed of magnetic discs and is roughly 2 millimeters thick — about double the size of a ballpoint pen tip — and less than a-tenth-of-an-inch long.

In the future, the robot's use could be expanded to help doctors better, and more thoroughly, investigate other organs, such as the human heart, kidney or pancreas, they said....

The robot is still 5 to 10 years away from showing up in a clinical setting, researchers said, but the device comes on the heels of a fleet of other robotic innovations allowing doctors the ability to better scan a patient's lungs for cancerous tissue. They are designed to ease a task doctors have long struggled with: reaching the inner recesses of the human body, for diagnostic and treatment purposes, without causing damage or using invasive procedures.... [I]ts smaller size and magnetic composition would allow it to shape-shift more easily and better navigate the intricate shape of a lung's network of airways, which can look like a tree....

Once at its desired location, the robot could ultimately have the capability to take a tissue sample or deliver a clinical treatment.... Nitish V. Thakor, a professor of biomedical engineering at Johns Hopkins University, said the autonomous robot is "very novel and interesting technology" that could become potentially useful in areas outside the lungs, most notably the heart. The device's autonomous capability is its unique factor, he said, and has the capability to change invasive surgeries. "I can imagine a future," he said, "where a full [cancer-screening] CAT scan is done of the lungs, and the surgeon sits down on a computer and lays out this navigation path of this kind of a snake robot and says: 'Go get it.' "

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