French entrepreneur Helene Huby is emerging as one of Europe's most ambitious space leaders, with The Exploration Company raising a record $450 million Series C as it develops the Nyx cargo capsule, a crewed spacecraft, and a reusable heavy-lift rocket. Huby argues Europe risks falling irrelevance without a much larger rocket flying at high cadence. Her company is targeting a 400,000-pound-thrust methane engine test by 2028 and an aggressive 2033 timeline for the launcher. Ars Technica reports: "The fundraise we have done right now is not sufficient to build the massive rocket we have in mind, so there will be another fundraise," she said. "Right now, we're going to be very, very focused on the execution. We must dock with the space station, with the capsule, as fast as possible. We must build this rocket engine and de-risk it as fast as possible. I think once one of these two milestones is achieved, we'll be talking fundraise again."

Critics may look at Huby and her company and say that is a lot of big talk for a company that only has a single, partial success in spaceflight to its credit. And sure, it is. But that's kind of the point. So much of the spaceflight community in Europe has been concerned with either the large aerospace primes seeking government handouts to protect their turf or small launch startups. There has been a stunning lack of big, visionary thinking.

Few people on the continent seem to recognize that multibillion investments by US companies such as SpaceX, Blue Origin, and Amazon in space, and their many imitators in China, are radically transforming spaceflight. As the world changes, Huby does not seem willing to stand on the sidelines in Europe and bemoan capitalism in space. Rather, she seems to be saying it is not too late for Europe to seize the day.

"We need to have European politicians who are ambitious," she said. "Entrepreneurs cannot do this alone. We need to be backed by the politicians and by the European Space Agency. But we have to start by achieving the crazy targets that we've set up for ourselves. That will give trust to others to believe in what we're doing."

alternative_right shares a report from ScienceDaily: A new analysis of more than 1,700 supernovae is questioning whether the universe is really accelerating at all. After accounting for the ages of the stars that produce these explosions, researchers found signs that cosmic expansion may actually be slowing. They also argue that the apparent acceleration changes with direction, which would be difficult to explain with dark energy. Other cosmologists dispute the conclusion, setting up a major test for upcoming observatories. The analysis has been published in Monthly Notices of the Royal Astronomical Society.

The conclusion is disputed, though. The report mentions a separate paper co-authored by Professor Maria Vincenzi, also at the University of Oxford, that "concludes that observations continue to support an accelerating universe."

An anonymous reader quotes a report from The New York Times: OpenAIsaid on Tuesday that its newest artificial intelligence technology had solved one of the "Millennium Problems," a collection of important unanswered math questions meant to push the world's leading mathematicians to new heights. The announcement is an another clear sign that A.I. is fundamentally changing the upper reaches of mathematics, which have long been viewed as a pinnacle of human achievement. The change has excited some mathematicians, while stirring concern among others.

Over the past year, A.I. systems successfully solved a wide range of problems that have bedeviled mathematicians for decades. But these problems were not as complex, nor as closely watched, as the one that OpenAI's technology has solved over the past several days. The Millennium Problems are among the most heavily researched in the field. "This is a spectacular culmination of the arc we have seen over the past twelve months," OpenAI researcher Sebastien Bubeck said of the company's new solution.

The company announced that one of its latest models, which has not yet been released to the public, needed just 88 hours to solve what mathematicians call "the Navier-Stokes existence and smoothness problem." This problem involves a series of equations that are often used to predict the weather. The equations describe the movement of water and other fluids. The Navier-Stokes problem, which has no clear practical value, asks whether these equations completely break down in certain situations. OpenAI's proof claims to have defined just such a situation.

This would imply, at least theoretically, that the laws of physics themselves would break down under certain conditions: that, for example, water could be made to spontaneously explode. But mathematicians and physicists do not believe that this mathematical breakdown could really lead to such an outcome in the physical world. The Navier-Stokes problem was one of seven "Millennium Problems" selected by the Clay Mathematics Institute in the year 2000 as a way of tracking the progress of mathematics in the new millennium. The institute, founded by an American businessman named Landon T. Clay, offered a million dollars for the first correct solution to each problem. Before OpenAI's announcement, only one of the problems had been solved. OpenAI says it managed to solve the Navier-Stokes problem by coordinating as many as 10,000 AI agents, an extremely expensive process that may have cost millions of dollars in computing power.

For those curious about the findings, the company has released a paper (PDF) and formal Lean proof.

"Billionaire Bill Ackman's life was upended this February when his 26-year-old daughter collapsed in her Brooklyn apartment, suffering a brain hemorrhage that would render her unable to move, speak or see," writes the Washingon Post. But then... The hedge fund manager did what any good father would do — at least, any father with vast financial resources and what friends describe as a "Mr. Fix-It" tendency. He sprung into action, getting her topline care at New York City's Mt. Sinai Hospital and consulting a network of well-connected friends all over the world. He helped her access a novel cell therapy that has been gaining traction among longevity enthusiasts, who are seeking ways to prolong human life. And then — motivated by a newfound desire to accelerate scientific research — he vowed to spend more than $400 million to launch an institute dedicated to longevity and brain health... He posted this week that the U.S. Food and Drug Administration, in May, gave his daughter Lucy's medical team a first-time emergency authorization to transplant mitochondria — the energy-producing part of human cells — from her leg muscle to her eyes, in the hopes that the tiny cell powerhouses would facilitate healing in her optic nerves and perhaps even restore her vision.

Ackman's story highlights the increasingly prominent role of the ultra-wealthy in making expensive medical bets on longevity treatments and other novel therapies, altering the direction of research as federal funding for science declines in the second Trump administration. But his saga is a deeply personal one, spurred by his daughter's medical crisis. The focus on longevity by Ackman, who made billions on Wall Street as a hedge fund manager, is aligned with similarly ambitious efforts from some of Silicon Valley's biggest names. OpenAI CEO Sam Altman has backed Retro Biosciences, a start-up whose goal is to add 10 healthy years to the human lifespan through cellular reprogramming. Amazon founder Jeff Bezos is reportedly a funder of Altos Labs, which focuses on cellular rejuvenation and resilience... Billionaire investor Peter Thiel, Google co-founder Sergey Brin and Oracle co-founder Larry Ellison are also deeply invested in life-extension methods and attempts to rewrite the biology of aging...

The therapy given to Ackman's daughter Lucy, known as mitochondrial transplantation, is of great interest not only to people who have suffered injuries, but to longevity-focused scientists who believe that mitochondria may hold promise for reversing some of the effects of aging... In recent years, scientists have discovered that mitochondria have many other functions beyond converting food into energy. They serve as clearinghouses for damaged cells, opening up the possibility that they can help with cell regeneration and healing, said Daria Mochly-Rosen, professor of chemical and systems biology at the Stanford University School of Medicine and co-author of " The Life Machines: How Taking Care of Your Mitochondria Can Transform Your Health."

"I am one of those who believes that focusing on mitochondrial health is a way to address many human diseases, including aging itself," she said. "It's exciting."

"No rocket had ever reached orbit from Western European soil — until today," reports Space.com.

DW.com reports that a Spectrum space rocket from German company Isar Aerospace launched today from the Arctic Norwegian spaceport at Andoya: "Germany has spaceflight capabilities," said the country's Ministry for Research, Technology and Space on X, praising a "milestone that impressively demonstrates our country's innovative strength and technical expertise". This was the German company's second attempt to launch the Spectrum rocket into space. The first attempt, which took place 18 months ago, was unsuccessful.

The Spectrum rocket is designed for small and medium-sized payloads. It carried five smal satellites and an in-flight technological experiment, the company said. According to Isar Aerospace, the launch was for "both the vehicle's qualification mission and its first flight carrying payload." The move is believed to bring Europe closer to being able to offer satellite flights from its own territory. Several countries voiced interest in the growing market of commercial space missions, including Britain and Sweden...

Isar is also working on the development of a second launch site, located in Canada. The company said that while the US launched 198 rockets last year, Europe's tally was just eight. Isar's goal is to produce some 40 rockets a year. Although the rocket is not yet ready for mass production, Isar has already received orders through 2028.
Today's launch webcast was produced in collaboration with NASASpaceflight, notes Space.com. And they note that Spectrum chief engineer Nikolaos Perakis says"This is just the beginning... I'm really looking forward to the next steps."

Reuters quotes this statemnt from Norway's minister of industry and commerce, Cecilie Myrseth. "The fact that we can now launch satellites from Andoeya strengthens Norwegian and European security in the turbulent times we live in."

CNN reports that alcohol "may play a greater role in death from numerous types of cancers in the United States than previously known, according to a new study." "While it's true that overall cancer mortality has declined, we found the percentage of cancer deaths proportionally attributable to alcohol rose over 58% in people 20 and older over the last 33 years," said the study's first author Dr. Chinmay Jani... It didn't take much alcohol to raise one's risk — about one standard drink a day, every day, Jani said. In the US, a standard drink is 12 ounces of regular beer, 5 ounces of wine or 1.5 ounces of 80-proof liquor...

Alcohol is ethanol or ethyl alcohol, which is broken down by the liver into acetaldehyde, a "probable human carcinogen," the National Cancer Institute states on its website. While the liver will further break down acetaldehyde into a harmless molecule called acetate, the process isn't foolproof: acetaldehyde may damage DNA and interfere with DNA repair before conversion into acetate is complete. Alcohol also contributes to oxidative stress, which damages DNA, proteins and cell function and creates inflammation. Drinking alcohol also weakens the cells in the mouth and throat, making them more susceptible to carcinogens. That's even more likely to occur with smoking cigarettes, a major source of acetaldehyde. In addition, alcohol interferes with the break down and absorption of key nutrients thought to decrease cancer risk — vitamins A, C, D and E as well as folates in the vitamin B complex, according to the National Cancer Institute.

The study, which was published Monday in The Lancet Regional Health — Americas journal, analyzed more than three decades of US data gathered for the Global Burden of Disease Study. The GBD study is a massive scientific effort to measure health, mortality and disabilities from hundreds of risk factors, diseases and conditions in more than 200 countries and territories. Between 1990 and 2023, the total number of yearly alcohol-linked cancer deaths more than doubled, rising from 11,361 to 23,126 in the US.

Men and adults age 55 and older experienced the greatest impact; alcohol-related cancer mortality rate in older males climbed nearly 24% over the 33-year period. For men, liver cancer deaths showed the strongest link to alcohol, followed by esophageal and colorectal cancers. For women 55 and older, breast cancer was the top killer, followed by liver and colorectal cancers.

A genetically modified pig kidney kept a 66-year-old man off dialysis for a record nine months, marking the longest survival yet for a pig kidney transplanted into a living person and the first time such an organ successfully served as a bridge to a later human transplant. The Guardian reports: Tim Andrews was seriously ill with end-stage kidney disease caused by type 2 diabetes and had only a 9% chance of receiving a human kidney within five years, against a more than 40% risk of dying or being removed from the waiting list. Kidney transplantation provides the best survival and quality of life for patients with end-stage kidney disease, but global demand for human organs far exceeds supply.

Surgeons in the US successfully transplanted a kidney from Wilma, a Yucatan miniature pig, into Andrews, after genetically engineering it to be compatible with his immune system. The kidney kept Andrews free of dialysis for a record nine months, the longest period ever recorded, before it began failing and he received one from a dead human donor. It was also the first time a pig's kidney had been used as a temporary "bridge" to a human transplant. The breakthrough has been detailed in the journal Lancet.

NASA has awarded Blue Origin a contract worth up to $700 million to build and operate a dedicated Mars telecommunications network for current and future missions to the Red Planet. Blue Origin is expected to deliver the spacecraft by the end of 2028, with the network targeted to become operational by 2030. From a press release: Blue Origin will design, develop, integrate, launch, and operate the network as a part of the agency's broader space communications and navigation infrastructure. The architecture will consist of a high-performance telecommunications spacecraft orbiting Mars, transmitting science data, imagery, navigation information, and critical mission communications for spacecraft operating on and around the planet.

The award marks a milestone in NASA's strategy to expand communications and navigation services beyond Earth and the Moon, establishing the foundation for sustained exploration of Mars in the coming decades.

New submitter greytree shares a report from Brown University: LUX-ZEPLIN, an experiment co-led by Brown University faculty and students, observed a particle interaction that could be interpreted as a signal from WIMPs, a dark matter candidate -- but researchers need more data to confirm. [...] The result does not yet meet the statistical threshold required to claim a discovery, but it is the most compelling hint of dark matter reported by the experiment to date. "We're very intrigued to see this event in the data, in the region where we expect dark matter to show up, and the competing backgrounds are very low," said Rick Gaitskell, a professor of physics at Brown University and the spokesperson for LZ. "With only one event, we don't want to get ahead of ourselves. We are not claiming to have seen dark matter. But we have seen something interesting that we want to share with the scientific community for their input." [...]

If the anomalous event was caused by dark matter, the WIMP that generated it would likely have a mass of at least 200 GeV/c2 (gigaelectronvolts), or more than 200 times the mass of a proton. The LZ results have not reached "5-sigma" significance, the statistical threshold in physics that an event must reach to be considered a discovery. The new analysis is 2.6 sigma, meaning there is approximately a 0.5% chance that the event could be explained by known backgrounds. With additional data, researchers can test whether the finding continues to grow in significance or fades away. LZ has already accumulated the world's largest dark matter dataset and will continue to accrue WIMP search data at SURF, substantially improving their search statistics.

JiJi Fan, an associate professor of physics at Brown not involved in the LZ experimental research but whose theoretical work is cited in the new LZ paper, said the new findings were "very intriguing." While the event recorded by LZ could not have been the simplest type of WIMP interaction, there are other types of possible interactions that could explain it, she said. Had a WIMP interacted in the simplest way at the high energy associated with this recent event, the detector would have recorded many recoil events at lower energies following the initial event. LZ recorded a single event, however, which requires an expanded theoretical explanation. "There are well-motivated theoretical extensions, including inelastic scattering and momentum-dependent elastic scattering, that could potentially account for this single event," Fan said. "This also sets up a target for on-going dark matter hunting, not only at direct detection experiments such as LZ but also at other complementary experimental frontiers." The results were presented in a scientific talk at the 2026 TeV Particle Astrophysics conference in Japan on Tuesday, Sept. 1. A paper detailing the finding can be found here (PDF).

Researchers have found that tiny electrical charges picked up by moving water droplets may be damaging cars and buildings like the Eiffel Tower. In experiments, thousands of charged droplets degraded Teflon and corroded the copper beneath it, while uncharged droplets caused no comparable damage. C&EN reports: For years, researchers at the Max Planck Institute for Polymer Research have studied how water droplets from rain, dew, ocean waves, and melting snow become electrically charged. They say the process is like tribocharging, which causes static when we rub certain objects together, such as a balloon on our hair or a sweater on our skin. "Water drops spontaneously become electrically charged when moving on different surfaces, such as plant leaves, insect wings, building walls, window glass, and plastic. This process, known as contact or sliding electrification, is analogous to tribocharging between solids," says study coauthor Zhongyuan Ni, a PhD candidate at Max Planck. "Water drops getting charged is not a new phenomenon, but for the past 200 years, people have not paid attention to this," Ni says.

In 2023, Ni and colleagues set out to determine whether electrically charged water droplets affect the surfaces they contact. To find out, the team poured water over four common surfaces -- a plant leaf; polyvinyl chloride foam board; polystyrene glass; and perfluoro octadecyltrichlorosilane (PFOTS), a commonly used water-repelling coating -- and let it drip onto sheets of Teflon-coated copper tilted at 50 degrees. When the experiments began, the team would allow only a few dozen drops to fall onto the copper before using electron microscopy to examine it. The researchers repeatedly failed to find any evidence of decay. But one day, Ni just let the drops keep falling. "After thousands of drops, it looked like the drops were pinning onto the surface," he says. After inspecting the copper under the microscope, Ni got his first glimpse of the destructive strength of electrically charged water drops.

After repeating the experiment several times with thousands rather than dozens of drops, the researchers found that the electrified water drops not only broke down the Teflon coating but also corroded the underlying copper. Up close, the copper sheets looked like scraped-up skin. But when the experiment was conducted with nonelectrified drops, neither the copper nor its Teflon coating was any worse for wear. Even though the drops contained only around 0.2 to 2.0 nanocoulombs of charge -- around one billionth of a standard unit -- the impact of the charged drops was significant. "The finding is important because it suggests that the electrical state of a water droplet, not just its chemical composition, acidity, or mechanical impact, can influence how corrosion begins," says Guangwen Zhou, a professor of mechanical engineering at Binghamton University who was not involved in the study.

"This perspective could open up new approaches to designing protective coatings and materials that are more resistant to corrosion in environments where charged water droplets are present."

ScienceDaily reports: A microchip about the size of a grain of rice can generate a highly organized "rainbow" of light, a capability that could eventually support faster, higher-capacity 6G communications and extremely precise timing for quantum technologies. Physicists at Loughborough University, working with an international research team, demonstrated a system that produces a series of precisely spaced light frequencies. Those optical frequencies can then be converted into multiple high-frequency electromagnetic signals known as millimeter waves.

Millimeter waves are attracting growing interest for future communications because they can provide considerably more bandwidth, giving networks more room to transmit data. A major obstacle, however, has been producing these signals with the precision and stability required for advanced applications... "They could ultimately contribute to faster, higher capacity 6G networks," [said Dr. Luke Peters, of Loughborough University's Emergent Photonics Research Centre], "but the potential goes far beyond communications. These frequencies could also be used in radar systems as well as spectroscopy and astronomical instruments, helping scientists study materials and make extremely precise measurements of the universe.

"These applications are still some way off, and there are challenges to overcome before the technology can be used in real-world systems — but our latest work has tackled a major one..." A microcomb generates an extremely precise set of light frequencies arranged somewhat like the colors in a rainbow, although the light itself is invisible to the human eye. A specialized antenna can then convert those optical frequencies into millimeter waves. Earlier research demonstrated that microcombs could produce a single precise millimeter wave frequency. Generating many frequencies simultaneously could be far more useful because each could potentially serve as a separate channel for transmitting information at the same time. Achieving that, however, requires a microcomb with exceptional stability and signal quality.

In a new Nature Communications paper, the Loughborough led researchers report a system capable of doing exactly that.
Their system connects its chip-based microresonator to a much larger loop of optical fiber where laser light continuously travels through both parts of the system, according to the article.

"The team is now investigating how the microcomb system could eventually move from a laboratory experiment into practical technology."

A team of researchers at Southern Illinois University Carbondale engineered yeast to create cookies that were 3D printed out of plastic waste, reports Futurism: The yeast breaks down the components of plastic compounds and agricultural byproducts like discarded plant stalks into proteins, fats, acids, and flavorings that we can eat. When these are combined together, the mixture is fed into a 3D printer that spits out cookies of any desired shape. The researchers chose to print their cookies as the Greek letter Â, creating what they call "ÂBites" — or micro bites. They haven't actually eaten one of their ÂBites yet, as they wait for university approval... "I think it has a pleasant, appealing aroma," Lahiru Jayakody, a microbiologist at SIU who led the research, told NewScientist. "And it will taste good, too. We've not tasted it, but it smells good — that's for sure — like a real cookie...."

The researchers used CRISPR gene-editing technology to reprogram yeast strains to eat polyethylene terephthalate (PET), a widely used form of plastic commonly found in disposable water bottles, food packaging, and clothes, which is rich with carbon. Before the yeast can start feasting, the PET plastics are subjected to a process called oxidative hydrothermal dissolution to break them down into smaller bits that the microbes can digest. The purported advantage of this approach is that it's environmentally friendly, using only heat, water, and oxygen. The yeast feasts on these stripped-down plastic bits, turning them into a slurry of proteins, fats, and acids that're combined with fiber, starch, and sweetener to make them more palatable. One of the yeast strains in particular was able to turn plant biomass into tasty vanilla flavorings...

[R]ight now, it's an expensive process, costing around $60 to produce a kilogram of cookies, The Guardian reported. And some experts say it's wishful thinking to believe we can 3D-print, and then eat, ourselves out of these global problems with 3D-printed, delectable treats. "We produce 400 million tons a year of plastic waste. You're not going to turn it all into cookies," Jason Hallett at Imperial College London told New Scientist. "So it's not a solution to the plastic-waste crisis. There's no way you could do this commercially. We're not gonna be eating plastic cookies."
Thanks to Slashdot reader fjo3 for sharing the article.

SpaceX is scheduled to launch the Roman Space Telescope on a Falcon Heavy rocket, with the launch window opening at 7:26 a.m. EDT (1126 GMT). NASA will carry the launch live on YouTube.

CNN offers this mission overview from NASA Administrator Jared Isaacman. "Roman will investigate dark matter, dark energy and the structure of the universe itself, and accelerate the future of discovery of potentially habitable planets outside our solar system." In fact, "NASA anticipates that Roman will image more than 50 times as much of the sky in the next five years as Hubble covered in three decades," reports USA Today, noting that "every single image it beams back to Earth will contain the equivalent of 100 pictures Hubble would capture." The barrel-shaped Roman telescope is due to set up operations nearly 1 million miles from Earth and begin scouring previously unobservable areas of the cosmos... NASA will make all of Roman's data available for anyone to peruse, meaning astronomers from all over the world will have the opportunity to make use of the observatory for advanced research, NASA says... Spanning 42 feet long and more than 14 feet wide, the Nancy Grace Roman Space Telescope is outfitted with two primary instruments
Its 300-megapixel near-infrared camera is built to look across the universe and study the three-dimensional distribution of dark matter, reports The Conversation. But it's also carrying a coronagraph instrument built to dramatically reduce the glare from distant stars "that will test the technology for future missions that plan to detect Earth-like planets around other stars."

The mission's generating some excitement. "Nearly three decades after dark energy's discovery, astronomers are letting themselves hope that a breakthrough is almost at hand," writes Scientific American, adding that cosmologists "are increasingly questioning the validity of their vaunted standard model, although no one can decide exactly what comes next." Roman will chase down three different ways of detecting dark energy, seeking to more precisely define what its effects on the universe are and whether they're changing over time. The first one involves surveying the skies for a special variety of supernova that's so predictable that scientists can use it as a beacon for calculating what a host galaxy's distance is and how fast it's moving away from us — the same technique that first betrayed dark energy back in the 1990s. The second entails mapping large numbers of galaxies to discern huge, faint bubbles in the cosmos that represent the fossilized signatures of sound waves that froze out of the universe's primordial plasma as it expanded and cooled. The sizes of those bubbles scale with the size and growth of the very early universe, offering a powerful probe for studying cosmic change over time. The third tracer uses a technique called microlensing, which reveals clumps of dark matter via their warping of background starlight, to fill in scientists' still incomplete reckoning of matter's cosmic distribution.
The Houston Chronicle reports that the telescope will also study rogue planets, isolated black holes, starquakes and planet-forming disks around nearby stars. "Almost regardless of what your scientific interest is, Roman is probably already planning to take observations," Julie McEnery, Roman's senior project scientist at NASA, said during a July news conference."
NBC News reports that after the Roman telescope launches, "it's set to spend more than three months journeying to its final destination, located roughly 1 million miles from Earth." Three primary surveys are planned over the course of the Roman telescope's mission. During the largest one, which will last over a year, the telescope will peer through the Milky Way's dense, star-packed center, known as the galactic bulge, building a vast catalog of all the astronomical objects it observes. The second and third surveys will focus on dark matter and dark energy.
Axios notes that Roman's primary mirror "is about the same size as that of Hubble's, but at 80% less weight — reflecting huge tech advancements since Hubble was built in the 1970s." And NPR reports NASA began planning the $4.3 billion telescope 15 years ago to search for supernovas to help explore dark energy — when "a call came in from the government office in charge of surveillance satellites." "The National Reconnaissance Office reached out to NASA," [remembers cosmologist Daniel Scolnic at Duke University], "saying, 'We have this amazing satellite sitting in a hangar that we're not using. And what what do you guys think about instead of pointing downwards, we point upwards, and you guys use it?'" NASA said yes. It took some substantial modifications, but now that old satellite is set to become NASA's next major space observatory....

Another goal of the telescope is to spend a month surveying all the stars in the Milky Way galaxy. Julie McEnery is Roman's project scientist. She says even though Roman has broadly the same sensitivity and sharpness of vision as the currently orbiting Hubble Space Telescope, its design lets it do things much faster. "That one month of observations to survey our Milky Way galaxy would take about a century with Hubble," says McEnery.

CNN reports that "A one-time snip of a key gene lowered heart-clogging cholesterol by about 50% over an entire year with no adverse effects, scientists have reported." The overwhelmingly positive results were found in four people who had taken the highest dose of the experimental treatment during a pilot study published in The New England Journal of Medicine in November 2025. That study was extremely small — only 15 patients with dangerously high cholesterol that did not respond to medication. The research was designed to test the safety of five different doses of a gene-altering infusion delivered by CRISPR-Cas9, a biological scissor which cuts a targeted genetic location to modify or turn a gene on or off. "If you'd asked me 15 years ago if we could have done something like this, I would have thought you were crazy," senior study author Dr. Steven Nissen, chief academic officer of the Sydell and Arnold Miller Family Heart, Vascular & Thoracic Institute at Cleveland Clinic in Ohio, told CNN previously.

An update on the study, published Friday in NEJM, appears to answer a key question: Does the intervention last? "Is something like this truly a one and done? That was always the question," said lead study author Dr. Luke Laffin, a preventive cardiologist at Cleveland Clinic's Heart, Vascular & Thoracic Institute. "This new data is essentially saying that the decreases in LDL cholesterol and triglycerides we saw at 60 days after treatment have lasted over a year," Laffin said. "In people who took the highest dose, the reduction seems durable and safe...."

If larger clinical trials show similar results, the procedure could be a game changer for young people with severe disease, preventive cardiologist Dr. Ann Marie Navar, an associate professor of cardiology at UT Southwestern Medical Center in Dallas, told CNN previously. "If you're 20 and you have really high cholesterol, it may make a lot more sense to have a one-time treatment that doesn't require you to have to take a pill every single day or shot every two weeks for the next 60 years," said Navar, who was not involved in the study. "The potential for this is just enormous."
Being born with this mutation naturally "drastically lowers or even eliminates a person's risk for heart disease," the article points out. And the study's senior author adds "now that CRISPR is here, we have the ability to change other people's genes so they too can have this protection."

An anonymous reader quotes a report from The Guardian: A common sweetener used in products such as chewing gum, toothpaste, jam, yoghurts and ice-cream has been linked to an increased risk of strokes, heart attacks and death. Xylitol is a sugar alcohol present in some natural foods in very low amounts. It is also added -- often in amounts 1,000 times higher -- to artificially sweeten foods, beverages and oral care products. Despite its growing use, the long-term health impacts of xylitol have never been widely studied.

In the largest study of its kind, researchers found high blood levels of xylitol were associated with an increased risk of major adverse cardiovascular events. The findings were presented in Munich at the European Society of Cardiology (ESC) annual congress, the world's largest heart conference. Researchers looked at 17,710 people and compared the 25% with the highest levels of xylitol in their blood against the 25% with the lowest. Those who had the highest amount were 57% more likely to die or suffer a heart attack or stroke, than those with the least, within six years. Even after 30 years, they were still 18% more likely to have suffered one of these cardiac events.

Taken with data from the middle quartiles, the results from both cohorts suggested a dose-dependent relationship: the higher the xylitol blood levels, the higher the cardiovascular event rate. Furthermore, the researchers showed that there was consistent increase in cardiovascular events with xylitol irrespective of baseline characteristics, such as age and sex. The researchers also highlighted that the association was independent of underlying factors such as body mass index, hypertension, diabetes and lipid levels, which might predispose people to low-calorie products.