Climate scientists trying to predict how much hotter the planet will get have long grappled with a surprisingly stubborn problem -- clouds, which both reflect sunlight and trap heat, account for more than half the variation between climate predictions and are the main reason warming projections for the next 50 years range from 2 to 6 degrees Celsius.

Two research groups are now racing to close that gap using AI, though they disagree sharply on method. Tapio Schneider at Caltech built CLIMA, a model that uses machine learning to optimize cloud parameters within traditional physics equations; it will be unveiled at a conference in Japan in March. Chris Bretherton at the Allen Institute for AI took a different path -- his ACE2 neural network, released in 2024, learns from 50 years of atmospheric data and largely bypasses physics equations altogether.

A study published last week in PNAS found that people who regularly cause problems or make life difficult -- whom the researchers call "hasslers" -- are associated with measurably faster biological aging in those around them, at a rate of roughly 1.5% per additional hassler and about nine months of additional biological age relative to same-age peers.

The research drew on DNA methylation-based epigenetic clocks and ego-centric network data from a state-representative probability sample of 2,345 adults in Indiana, aged 18 to 103. Nearly 29% of respondents reported at least one hassler in their close network. The biological toll varied by relationship type: hasslers who were family members showed the strongest and most consistent associations with accelerated aging, while spouse hasslers showed no significant effect on either epigenetic measure.

The damage also went beyond aging clocks -- each additional hassler was associated with greater depression and anxiety severity, higher BMI, increased inflammation, and higher multimorbidity. When benchmarked against smoking, a major behavioral risk factor for aging, the hassler effect corresponded to roughly 13 to 17% of smoking's estimated impact on the same aging clocks.

"A surprisingly ravenous black hole from the dawn of the universe is breaking two big rules," reports Live Science. "It's not only exceeding the 'speed limit' of black hole growth but also generating extreme X-ray and radio wave emissions — two features that are not predicted to coexist..."

"How is this rule-breaking behavior even possible? In a paper published Jan. 21 in The Astrophysical Journal, an international team of researchers observed ID830 in multiple wavelengths to find an answer...." As they attract gas and dust, this material accumulates in a swirling accretion disk. Gravity pulls the material from the disk into the black hole, but the infalling material generates radiation pressure that pushes outward and prevents more stuff from falling in. As a result, black holes are muzzled by a self-regulating process called the Eddington limit... Its X-ray brightness suggests that ID830 is accreting mass at about 13 times the Eddington limit, due to a sudden burst of inflowing gas that may have occurred as ID830 shredded and engulfed a celestial body that wandered too close. "For a supermassive black hole (SMBH) as massive as ID830, this would require not a normal (main-sequence) star, but a more massive giant star or a huge gas cloud," study co-author Sakiko Obuchi, an observational astronomer at Waseda University in Tokyo, told Live Science via email. Such super-Eddington phases may be incredibly brief, as "this transitional phase is expected to last for roughly 300 years," Obuchi added.

ID830 also simultaneously displays radio and X-ray emissions. These two features are not expected to coexist, especially because super-Eddington accretion is thought to suppress such emissions. "This unexpected combination hints at physical mechanisms not yet fully captured by current models of extreme accretion and jet launching," the researchers said in a statement. So while ID830 is launching massive radio jets, its X-ray emissions appear to originate from a structure called a corona, produced as intense magnetic fields from the accretion disk create a thin but turbulent billion-degree cloud of turbocharged particles. These particles orbit the black hole at nearly the speed of light, in what NASA calls "one of the most extreme physical environments in the universe." Altogether, ID830's rule-breaking behaviors suggest that it is in a rare transitional phase of excessive consumption — and excretion. This incredible feeding burst has energized both its jets and its corona, making ID830 shine brightly across multiple wavelengths as it spews out excess radiation.

Additionally, based on UV-brightness analysis, quasars like ID830 may be unexpectedly common, the researchers said. Models predict that only around 10% of quasars have spectacular radio jets, but these energetic objects could be significantly more abundant in the early universe than previously suggested. Most importantly, ID830 also shows how SMBHs can regulate galaxy growth in the early universe. As a black hole gobbles matter at the super-Eddington limit, the energy from its resultant emissions can heat and disperse matter throughout the interstellar medium — the gas between stars — to suppress star formation. As a result, ancient SMBHs like ID830 may have grown massive at the expense of their host galaxies.

"More than four decades after a teenager was murdered in California, DNA found on a discarded cigarette has helped authorities catch her killer," reports CNN: Sarah Geer, 13, was last seen leaving her friend's houseï in Cloverdale, California, on the evening of May 23, 1982. The next morning, a firefighter walking home from work found her body, the Sonoma County District Attorney's Office said in a news release... Her death was ruled a homicide, but due to the "limited forensic science of the day," no suspect was identified and the case went cold for decades, prosecutors said.

Nearly 44 years after Sarah's murder, a jury found James Unick, 64, guilty of killing her on February 13. It would have been the victim's 57th birthday, the Sonoma County District Attorney's Office told CNN. Genetic genealogy, which combines DNA evidence and traditional genealogy, helped match Unick's DNA from a cigarette butt to DNA found on Sarah's clothing, according to prosecutors... [The Cloverdale Police Department] said it had been in communication with a private investigation firm in late 2019 and had partnered with them in hopes the firm could revisit the case's evidence "with the latest technological advancements in cold case work...."

"The FBI, with its access to familial genealogical databases, concluded that the source of the DNA evidence collected from Sarah belonged to one of four brothers, including James Unick," prosecutors said. Once investigators narrowed down the list of suspects to the four Unick brothers, the FBI "conducted surveillance of the defendant and collected a discarded cigarette that he had been smoking," prosecutors said. A DNA analysis of the cigarette confirmed James Unick's DNA matched the 2003 profile, along with other DNA samples collected from Sarah's clothing the day she was killed.
In a statement, the county's district attorney "While 44 years is too long to wait, justice has finally been served..."

And the article points out that "In 2018, genetic genealogy led to the arrest of the Golden State Killer, and it has recently helped solve several other cold cases, including a 1974 murder in Wisconsin and a 1988 murder in Washington."

CNN reports on a 13,000-year-old glacier in a Romanian cave, where scientists say a bacterial strain they thawed and analyzed "is resistant to 10 modern antibiotics used to treat diseases such as urinary tract infections and tuberculosis."

But there's no evidence the bacteria is harmful to humans, CNN notes, and "The scientists said the insights they have gained from the work may help in the fight against modern superbugs that can't be treated by commonly used antibiotics." Analysis of the Psychrobacter SC65A.3 genome revealed 11 genes that are potentially able to kill or stop the growth of other bacteria, fungi and viruses... Matthew Holland, a postdoctoral researcher in medicinal chemistry at the UK's University of Oxford, said that researchers were searching in new and extreme environments, such as ice caves and the seafloor, for biomolecules that could be developed into new antibiotic drugs. He was not involved in the new study. "The team in Romania found this particular bug had resistance to 10 reasonably advanced synthetic antibiotics and that in itself is interesting," he said. "But what they report as well is that it secreted molecules that were able to kill a variety of already resistant, harmful bacteria.

"So the hope is that can we look at the molecules it makes and see if there's the possibility within those molecules to make new antibiotics."

An anonymous reader quotes a report from the Guardian: You wear them at work, you wear them at play, you wear them to relax. You may even get sweaty in them at the gym. But an investigation into headphones has found every single pair tested contained substances hazardous to human health, including chemicals that can cause cancer, neurodevelopmental problems and the feminization of males. [...] Researchers say that while individual doses from particular sources may be low, a "cocktail effect" of daily, multi-source exposure nevertheless poses potentially severe long-term risks to health. [...]

Researchers bought 81 pairs of in-ear and over-ear headphones, either on the market in the Czech Republic, Slovakia, Hungary, Slovenia and Austria, or from the online marketplaces Shein and Temu, and took them for laboratory analysis, testing for a range of harmful chemicals. "Hazardous substances were detected in every product tested," they said. Bisphenol A (BPA) appeared in 98% of samples, and its substitute, bisphenol S (BPS), was found in more than three-quarters. Synthetic chemicals used to stiffen plastic, BPA and BPS mimic the action of oestrogen inside organisms, causing a range of adverse effects including the feminization of males, early onset puberty in girls, and cancer. Previous studies have shown that bisphenols can migrate from synthetic materials into sweat, and that they can be absorbed through the skin.

"Given the prolonged skin contact associated with headphone use, dermal exposure represents a relevant pathway, and it is reasonable to assume that similar migration of BPA and its substitutes may occur from headphone components directly to the user's skin," the researchers said. Also found in the headphones tested were phthalates, potent reproductive toxins that can impair fertility; chlorinated paraffins, which have been linked to liver and kidney damage; and brominated and organophosphate flame retardants, which have similar endocrine disrupting properties to bisphenols. Most were, however, found in only trace quantities.

Researchers at the Thomas Jefferson National Accelerator Facility are advancing Accelerator-Driven Systems (ADS) that use high-energy proton beams to transmute long-lived nuclear waste into shorter-lived isotopes. "The process also generates significant heat, which can be harnessed to produce additional electricity for the grid," reports Interesting Engineering. The projects are supported by $8.17 million in grants from the Department of Energy's NEWTON (Nuclear Energy Waste Transmutation Optimized Now) program. From the report: The researchers are developing ADS technology. This system uses a particle accelerator to fire high-energy protons at a target (such as liquid mercury), triggering a process called "spallation." This releases a flood of neutrons that interact with unwanted, long-lived isotopes in nuclear waste. The technology can effectively "burn" the most hazardous components of the waste by transmuting these elements. While unprocessed fuel remains dangerous for approximately 100,000 years, partitioning and recycling via ADS can reduce that window to just 300 years. [...]

To make ADS economically viability, Jefferson Lab is tackling two primary technical hurdles: efficiency and power. Traditional particle accelerators require massive, expensive cryogenic cooling systems to reach superconducting temperatures. Jefferson Lab is pioneering a more cost-effective approach by coating the interior of pure niobium cavities with tin. These niobium-tin cavities can operate at higher temperatures, allowing for the use of standard commercial cooling units rather than custom, large-scale cryogenic plants. The team is also developing spoke cavities, which is a complex design intended to drive even higher efficiency in neutron spallation.

The second project focuses on the power source behind the beam. Researchers are adapting the magnetron -- the same component that powers microwave ovens -- to provide the 10 megawatts of power required for ADS. The primary challenge is that the energy frequency must match the accelerator cavity precisely at 805 Megahertz. In collaboration with Stellant Systems, researchers are prototyping advanced magnetrons that can be combined to reach the necessary high-power thresholds with maximum efficiency. The NEWTON program aims to enable the recycling of the entire US commercial nuclear fuel stockpile within the next 30 years.

An anonymous reader quotes a report from NPR: NASA could launch four astronauts on a mission to fly around the moon as soon as March 6th. That's the launch date (PDF) that the space agency is now working towards following a successful test fueling of its big, 322-foot-tall moon rocket, which is standing on a launch pad at the Kennedy Space Center in Florida.

"This is really getting real," says Lori Glaze, acting associate administrator of NASA's exploration systems development mission directorate. "It's time to get serious and start getting excited." But she cautioned that there's still some pending work that remains to be done out at the launch pad, and officials will have to conduct a multi-day flight readiness review late next week to make sure that every aspect of the mission is truly ready to go. "We need to successfully navigate all of those, but assuming that happens, it puts us in a very good position to target March 6th," she says, noting that the flight readiness review will be "extensive and detailed." [...]

When NASA workers first tested out fueling the rocket earlier this month, they encountered problems like a liquid hydrogen leak. Swapping out some seals and other work seems to have fixed these issues, according to officials who say that the latest countdown dress rehearsal went smoothly, despite glitches such as a loss of ground communications in the Launch Control Center that forced workers to temporarily use backups.

NASA has officially classified Boeing Starliner's 2024 crewed flight as a "Type A" mishap, acknowledging serious technical failures and leadership shortcomings that nearly left astronauts unable to safely return. Administrator Jared Isaacman released (PDF) a 311-page internal report citing flawed decision-making and cultural issues, with the next Starliner flight now planned as uncrewed pending major fixes. Ars Technica reports: As part of the announcement, NASA Administrator Jared Isaacman sent an agency-wide letter that recognized the shortcomings of both Starliner's developer, Boeing, as well as the space agency itself. Starliner flew under the auspices of NASA's Commercial Crew Program, in which the agency procures astronaut transportation services to the International Space Station. "We are taking ownership of our shortcomings," Isaacman said.

"Starliner has design and engineering deficiencies that must be corrected, but the most troubling failure revealed by this investigation is not hardware," Isaacman wrote in his letter to the NASA workforce. "It is decision-making and leadership that, if left unchecked, could create a culture incompatible with human spaceflight." Isaacman said there would be "leadership accountability" as a result of the decisions surrounding the Starliner program, but did not say which actions would be taken.

An anonymous reader quotes a report from Scientific American: Why does "bouba" sound round and "kiki" sound spiky? This intuition that ties certain sounds to shapes is oddly reliable all over the world, and for at least a century, scientists have considered it a clue to the origin of language, theorizing that maybe our ancestors built their first words upon these instinctive associations between sound and meaning. But now a new study adds an unexpected twist: baby chickens make these same sound-shape connections, suggesting that the link to human language may not be so unique. The results, published today in Science, challenge a long-standing theory about the so-called bouba-kiki effect: that it might explain how humans first tethered meaning to sound to create language. Perhaps, the thinking goes, people just naturally agree on certain associations between shapes and sounds because of some innate feature of our brain or our world. But if the barnyard hen also agrees with such associations, you might wonder if we've been pecking at the wrong linguistic seed.

Maria Loconsole, a comparative psychologist at the University of Padua in Italy, and her colleagues decided to investigate the bouba-kiki effect in baby chicks because the birds could be tested almost immediately after hatching, before their brain would be influenced by exposure to the world. The researchers placed chicks in front of two panels: one featured a flowerlike shape with gently rounded curves; the other had a spiky blotch reminiscent of a cartoon explosion. They then played recordings of humans saying either "bouba" or "kiki" and observed the birds' behavior. When the chicks heard "bouba," 80 percent of them approached the round shape first and spent an average of more than three minutes exploring it compared with an average of just under one minute spent exploring the spiky shape. The exploration preferences were flipped when the chicks heard "kiki."

Because the tests took place within the chicks' carefully supervised first hours of life outside their eggshell, this association between particular sounds and shapes couldn't have been learned from experience. Instead it may be evidence of an innate perceptual bias that goes back way farther in our evolutionary history than previously believed. "We parted with birds on the evolutionary line 300 million years ago," says Aleksandra Cwiek, a linguist at Nicolaus Copernicus University in Toru, Poland, who was not involved in the study. "It's just mind-blowing."

An anonymous reader shares a report: In 2013, scientists unveiled the first lab-grown burger at a cost of $330,000. By 2023, the FDA approved cultivated chicken for sale. The price had dropped to around $10-$30 per pound, and over $3 billion in investor money had poured into more than 175 companies developing meat grown from animal cells instead of slaughtered animals.

The promise is straightforward: real meat, no slaughter required. You could eat beef without killing cattle, chicken without industrial farming, steak without ethical compromise. The technology works. Federal regulators approved it as safe. And nearly a third of US states have banned it or are trying to. Not because it's dangerous -- because it threatens something deeper than food safety.

Start with a small sample of animal cells -- a biopsy, not a slaughter. Place them in a bioreactor with nutrients. The cells multiply, forming muscle tissue identical to conventional meat at the cellular level. Nutritionally comparable, same protein content, but grown without raising and killing an animal.

The process uses 64-90% less land than conventional meat production and drastically reduces greenhouse gas emissions. No factory farms, no slaughterhouses, no ethical compromise for people who love meat but hate industrial animal agriculture. For vegetarians who gave up meat for ethical reasons, it offers something impossible before: guilt-free steak.

[...] Here's where the dream hits reality. Consumer surveys show people perceive conventional meat as tastier and healthier than lab-grown alternatives. Fewer consumers are willing to try cultivated options than expected. The words "lab-grown" and "cultivated" don't exactly make mouths water.

Something about meat grown in a bioreactor triggers deep discomfort for many people, even those who claim to care about animal welfare and environmental impact. It's the same psychological barrier that made "Frankenfood" stick as a label for GMOs. Meat is supposed to come from animals, raised on farms, connected to land and tradition. Growing it in a facility feels wrong to people in ways they struggle to articulate.

The Food and Drug Administration has reversed its decision on Moderna's flu vaccine and has agreed to review it for possible approval, Moderna announced on Wednesday. From a report: Last week, the agency rejected Moderna's application for review of a new flu vaccine, saying the company's research design was flawed. But in subsequent discussions the company said that the agency had relented and agreed to begin a review.

Moderna said it split its application for the flu vaccine based on age, seeking a traditional approval for people 50 to 64 years old, and accelerated approval for those 65 and older. The company also said it agreed to conduct an additional study among those 65 and older once the vaccine reached the market. Moderna said on Wednesday that the F.D.A. set a deadline of August to decide whether to approve the vaccine. If it is authorized, it would be available for those older adults in the flu season that begins later this year.

The vaccine uses messenger RNA technology, which Health Secretary Robert F. Kennedy Jr. has repeatedly criticized as unsafe and ineffective. The mRNA approach, which instructs the body to produce a fragment of a virus that sets off an immune response, was widely successful in Covid vaccines and is considered generally safe by public health experts and scientists.

In a small double-blind clinical trial, a single intravenous dose of DMT produced rapid and clinically meaningful reductions in symptoms of major depressive disorder within a week, with effects lasting up to three months in some patients. "Unlike psilocybin and lysergic acid diethylamide ( LSD), whose effects can last for hours, intravenous DMT has a half-life of around five minutes," notes ScienceAlert. "Its psychedelic effects are correspondingly brief, potentially making it more practical to administer in clinical settings." From the report: "A single dose of DMT with psychotherapeutic support produced a rapid, significant reduction in depressive symptoms, sustained up to three months," writes a team led by neuroscientists David Erritzoe and Tommaso Barba of Imperial College London. [...] They recruited 34 participants with major depression and divided them into two groups of 17 for a double-blind, placebo-controlled trial.

In the first stage of the trial, one group received an intravenous dose of DMT, while the other received an active placebo. Neither the researchers nor the participants were informed which participants received the DMT. The doses took around 10 minutes to administer, and a therapist sat with each participant to ensure comfort and safety while the psychedelic effects were active, remaining silent throughout the treatment. The treatment was generally well tolerated. Most side effects were mild to moderate, and included nausea, temporary anxiety, and pain at the injection site. No serious adverse events related to the treatment were reported, although brief increases in heart rate and blood pressure were observed immediately after dosing.

In the second, open-label stage, two weeks after the first dose, all participants were given the opportunity to receive a dose of DMT. Participants were assessed before and at intervals after each dose using the Montgomery-Asberg Depression Rating Scale. Just a week after the first dose, participants who had received DMT had improved scores compared to the placebo group, and improvements were sustained during follow-up assessments.

Two weeks after the first dose, the participants who received DMT scored about seven points lower, on average, than those who received a placebo. On this commonly used clinical scale, a drop of that size is generally considered a meaningful reduction in symptom severity. There was no significant difference between patients who received one or two doses of DMT, suggesting a single dose may be sufficient. These effects persisted for up to three months, and some patients remained in remission for at least six months following the treatment. The findings have been published in Nature Medicine.

Longtime Slashdot reader walterbyrd shares a report from ABC News: In a study of nearly 28 million older Americans, long-term exposure to fine particle air pollution raised the risk of Alzheimer's disease. That link held even after researchers accounted for common conditions like high blood pressure, stroke and depression. Fine particle air pollution, known as PM2.5, consists of tiny particles in the air that come from car exhaust, power plants, wildfires, and burning fuels, according to the American Lung Association. They are small enough to travel deep into the lungs and even reach the bloodstream.

The research, conducted at Emory University and published in PLOS Medicine, tracked health data over nearly two decades to explore whether air pollution harms the brain indirectly by causing high blood pressure or heart disease, which, in turn, leads to dementia. However, these "middleman" conditions accounted for less than 5% of the connection between pollution and Alzheimer's, the research found. The researchers say this suggests that over 95% of the Alzheimer's risk comes from the direct impact of breathing in dirty air, likely through inflammation or damage to brain cells. "The relationship between PM2.5 and AD [Alzheimer's disease] has been shown to be pretty much linear," said Kyle Steenland, a professor in the departments of environmental health and epidemiology at the Rollins School of Public Health at Emory University, and senior author of the study. "The reason this is particularly important is that PM2.5 is known to be associated with high blood pressure, stroke and depression -- all of which are associated with AD. So, from a prevention standpoint, simply treating these diseases will not get rid of the problem. We have to address exposure to PM2.5."

Up to a third of people worldwide have shoulder pain; it's one of the most common musculoskeletal complaints. But medical imaging might not reveal the problem -- in fact, it could even cloud it. From a report: In a study published in JAMA Internal Medicine this week, 99 percent of adults over 40 were found to have at least one abnormality in a rotator cuff on magnetic resonance imaging (MRI). The rotator cuff is the group of muscles and tendons in a shoulder joint that keeps the upper arm bone securely in the shoulder socket -- and is often blamed for pain and other symptoms.

The trouble is, the vast majority of the people in the study had no problems with their shoulders. The finding calls into question the growing use of MRIs to try to diagnose shoulder pain -- and, in turn, the growing problem of overtreatment of rotator cuff (RC) abnormalities, which includes partial- and full-thickness tears as well as signs of tendinopathy (tendon swelling and thickening). "While we cannot dismiss the possibility that some RC tears may contribute to shoulder symptoms, our findings indicate that we are currently unable to distinguish clinically meaningful MRI abnormalities from incidental findings," the study authors concluded.