An anonymous reader quotes a report from The Guardian: Scientists have made the first viruses designed by artificial intelligence in a milestone that raises hopes for new medicines but also concerns over how to ensure the technology remains safe. The viruses are specific kinds known as bacteriophages, which only infect bacteria and are used around the world to treat patients with persistent infections. In lab tests, a cocktail of the AI-designed viruses killed E coli bugs that were resistant to natural bacteriophages.

Dr Brian Hie, a chemical engineer at Stanford University in California, used genome language models, the genetic equivalent of the large language models behind AI chatbots, to design functioning genomes for bacteriophages. The viruses were then made in the laboratory and pitted against E coli in a dish. The ability to "rapidly design" genomes and tune them for specific bugs while overcoming resistance could "transform phage therapy" and "expand biotechnological toolkits," the researchers wrote in the journal Science.

But beyond the potential benefits, the scientists said the work raised "important biosafety, biocontainment and biosecurity considerations" and urged others who were designing whole genomes to "consult both safety and security professionals throughout the project." In an accompanying article, Prof Tom Inglesby and Dr Moritz Hanke at the Center for Health Security at Johns Hopkins University in Baltimore, reinforced the warning, writing: "Although this is promising for life sciences applications, it also raises urgent biosafety and biosecurity questions. The ability to compose viral genomes using generative AI now exists; the governance to safely steer it does not." Tom Ellis, a professor of synthetic genome engineering at Imperial College London, said the work was impressive, but revealed how hard it would be to make more complex genomes. "This is literally the smallest and easiest genome to make," he said. An AI trained on the genetic code of dangerous bugs could be used to design more harmful viruses, Ellis said, but controlling access to genetic data and having restrictions on making genomes that look dangerous would help. "Governments are working hard to do this already," he added. "But honestly," he said, "the threat from full AI design and writing of a genome of a virus or bacteria is very overblown when we consider that just taking existing pathogens and making gain-of-function changes to their genomes is so much easier and much more likely to be a real pathogenic threat."

Dr Filippa Lentzos, a reader in science and international security at King's College London, said the most important point to intervene at the moment was when DNA was being manufactured. "It's important to see the bigger governance picture and not focus regulation solely on the AI model," she said. "A layered approach makes more sense: safeguards around model development and access, responsible research review, synthesis screening, and established laboratory biosafety and biosecurity."

The FDA has approved the first mRNA flu vaccine in the United States after a clinical trial found it was about 27% more effective than a standard flu shot. Manufactured by Moderna and marketed as mFlusiva, the vaccine is expected to be available this fall for adults ages 50 to 64 and those 65 and older, though approval for the older group is conditional on Moderna conducting an additional clinical trial, NBC News reports. From the report: Many scientists and public health experts have touted the idea of an mRNA-based flu vaccine, which uses the same messenger RNA platform as the Covid vaccines from Moderna and Pfizer. That's because mRNA vaccines can be manufactured much faster than traditional vaccines, allowing scientists to better match circulating influenza strains. Moderna said it takes two to three months from picking the strain to rolling out its flu shot, compared with about six months for traditional flu shots.

An anonymous reader quotes a report from the Associated Press: Scientists have captured images of the sun's surface in the finest detail yet, revealing a strange and dynamic facade. It's dangerous to look directly at the sun without proper eye protection. But researchers were able to peek at its scorching surface with the help of the National Science Foundation's Daniel K. Inouye Solar Telescope, located on the island of Maui in Hawaii.

Scientists originally took the images for a different reason: to fine-tune and test the limits of the telescope. But when they looked at the results, they realized they'd photographed the sun's bright outer shell at higher resolution than ever before. What's more, they saw strange feathery patterns rippling across the surface. "That reminds me of famous paintings, like the swirling skies in Van Gogh's Starry Night," said solar physicist Ruizhu Chen with Stanford University, who was not involved with the new research.

Researchers saw ripples of instability on the sun's surface caused by bits of magnetized plasma moving past each other at different speeds -- similar to waves that stir when a gust of wind blows over water. It's a well-known phenomenon that guides how fluids move. This has been glimpsed on Earth and other planets like Jupiter and Saturn, but "it has not been observed ever at that level on the solar surface," according to study co-author Friedrich Woger with the National Solar Observatory. The findings were published Wednesday in the journal Nature.

A four-ton SpaceX Falcon 9 upper stage left drifting after a 2025 lunar mission is expected to crash into the Moon at about 5,400 mph, likely striking Einstein Crater. The impact should occur at approximately 2:35 a.m. ET (0635GMT). Reuters reports: Such stages typically fall back into Earth's atmosphere and burn up or plunge into the ocean after boosting the rocket's payload to a precise spot in orbit. But because the January lunar lander mission required more thrust than missions closer to Earth, the rocket's second stage remained in space, floating aimlessly among thousands of other pieces of space junk that active satellites must steer clear of. It was not until earlier this year that astronomers determined that the rocket stage, which had dumped its remaining fuel and cannot be controlled, was on an orbital trajectory ending at the moon.

"What has happened is essentially a mixture of solar activity and gravity forces have put it on a path toward the moon," Julianna Scheiman, SpaceX director of NASA science and Dragon programs, told reporters on Monday. "This may be of some -- probably minor -- scientific interest, and we may learn some things from it," said Bill Gray, creator of widely used astronomy software who published a report on the stage's impact in April. "It doesn't present any danger to anyone, though it does highlight a certain carelessness about how leftover space hardware (space junk) is disposed of." You can try to watch the impact via a livestream on YouTube; however, the area it's expected to hit (Einstein Crater) is on the moon's western limb, "which is often difficult to see from Earth," notes Reuters. It will also likely "kick up a plume of lunar dust that will likely be illuminated by sunlight but difficult to spot with the naked eye from Earth."

Longtime Slashdot reader schwit1 shares a report from Behind the Black: In a new bid to get the Thirty Meter Telescope (TMT) to move from Hawaii, which has blocked its construction for more than a decade, the Spanish government has put together a $1.14 billion package that would not only pay for construction on the Canary Islands, but would finance an additional half century of operations. Tech Times provides some additional details: The package is conditional on the TMT International Observatory formally choosing La Palma as its construction site. The financing architecture has three pillars and two additional contingent instruments. The first pillar is 400 million euros (approximately $456 million USD) from Spain's Ministry of Science, Innovation and Universities, routed through the Centre for Technological Development and Innovation (CDTI). This figure was first pledged a year ago in July 2025 as Spain's initial bid.

The second pillar is a 300 million-euro (approximately $342 million USD) loan from the EIB [European Investment Bank] itself -- subject to satisfactory completion of the bank's technical, financial, and legal due diligence and approval by its governing bodies.

The third is a potential 300 million-euro (approximately $342 million USD) participation from the Instituto de Credito Oficial (ICO), Spain's state development finance institution, evaluated under equivalent conditions to the EIB loan but subject to its own separate analysis. Spain's export credit agency, Cesce, may also provide coverage instruments, and the EIB has left open the possibility of expanding its support through intermediated financing mechanisms or guarantees.

An anonymous reader quotes a report from Forbes: The cost of producing new results on ten longstanding mathematical problems just fell to $2,000, according to OpenAI, which says its Astra model generated machine-checkable proofs for questions that had resisted human progress for decades. OpenAI published the work on August 1 and used it to give its next major model family a name: Astra. The results run across group theory, high-dimensional geometry, coding theory, quantum complexity, lattice cryptography and extremal combinatorics. They arrived as a 249-page manuscript collection and, alongside it, something the field has not seen attached to an AI claim before at this scale: a machine-checkable certificate for every single result.

The problems were not textbook exercises dressed up as discoveries. Each had been open for at least ten years, most of them far longer, and several sit at the center of their subfields:
- A construction establishing the existence of non-sofic groups, a question that has occupied group theorists for years.
- A disproof of Connes's rigidity conjecture, a long-standing problem in the theory of von Neumann algebras.
- An improvement to the general upper bound on sphere-packing density in high dimensions, a bound that had stood since 1978.
- Three problems come from the catalogue of open questions left behind by Paul Erdos. The announcement follows another result from May, when OpenAI used a similar reasoning model to produce an original mathematical proof disproving a famous unsolved conjecture in geometry, which was first posed by Paul Erdos in 1946.

"A major scientific review is challenging the idea that more protein is always better," reports ABC News: The review, led by pathologist and biomedical researcher Dudley Lamming and published in the journal Cell Press Blue, examined more than 350 studies involving humans, mice, insects, yeast, and other organisms. The review found that eating less protein, or less of certain amino acids that make up protein, may turn on body processes linked to healthier aging, as well as metabolism, the process by which the body turns food and drinks into energy...

For adults who already get enough, eating more protein may offer little benefit, while some research suggests that eating less protein could support healthier aging... Lamming reviewed the effect of reducing protein in many body processes. One of the processes involves a hormone called FGF21. "There's an increase in a hormone called FGF21 that promotes energy expenditure [when protein intake is reduced]," Lamming said. "It essentially increases thermogenesis in your adipose tissue, so you don't just store fat, but actually burn it as fuel." This may help explain why some studies connect lower-protein diets with less body fat, better blood sugar control and a healthier metabolism. Eating less protein may also affect signals that tell cells when to grow, repair damage or recycle old cell parts. These jobs may play a role in aging.

However, protein restriction is not the same as protein deficiency. The goal is not to deprive the body of an essential nutrient. Instead, the research raises the possibility that avoiding unnecessary excess could benefit some people who already consume enough... Before reaching for another high-protein product, a better question may be: How much protein does my body actually need?

"Scientists say they have detected promising signs that a planet orbiting a star 49 light-years from Earth could have an atmosphere," reports CNN, "making it potentially suitable for life." Called LHS 1140b, the object is about five times the mass of our planet, or a "super-Earth." This planet orbits around its star in the "Goldilocks zone," also known as the habitable zone, meaning its surface temperature is not too hot or too cold for liquid water to exist... "It appears to be consistent with Earth, meaning it might have an iron core and a silicate mantle, plus some sort of low-density component, which is probably a combination of water and, now we know, an atmosphere," [said Collin Cherubim, a planetary scientist and lead author of a paper on the finding, published July 16 in the journal Science]... If further observations confirm the findings, LHS 1140b would mark the first discovery of an atmosphere on a rocky planet in the habitable zone of another star...

There is no evidence of life or a life-supporting atmosphere on LHS 1140b now, but Cherubim said he believes it's a formidable candidate for potential signatures of extraterrestrial life. "I think it's the best place to look for life outside the solar system at this point," he said. "It's mostly rocky, it's at the right temperature to support liquid water on the surface, and it has an atmosphere — those are the three key ingredients we look for..." Confirming the existence of an atmosphere on a rocky planet orbiting a red dwarf would be particularly exciting, Cherubim said, because the possibility of that happening is an open question in astronomy. "Can rocky planets have atmospheres around red dwarfs? This is the first bona fide yes," he said. "It's kind of a sigh of relief for a lot of us. But the jury's still out. Maybe this is a weird planet, and it's an oddball, or maybe it's the first of many. We don't know yet."
Now "The James Webb Space Telescope is going to look at it," Cherubim told CNN, and "Hubble's going to look at it. Basically, everybody who can see it is going to be training their eyes on it."

Michaël Gillon, research director of the Astrobiology Research Unit at Belgium's University of Liège warned CNN that no definitive proof exists that LHS 1140b possesses a substantial atmosphere. But if the detection of helium can be confirmed, the implications would be profound. "Until now, we had only limited evidence for atmospheres on temperate rocky exoplanets. Demonstrating that LHS 1140 b has retained a substantial atmosphere over billions of years would show that at least some habitable zone Super-Earths around red dwarfs can survive the intense early activity of their host stars."

NASA's Curiosity rover has sent back images of honeycomb-like textures called polygonal fractures, each one about 1.5 to 3 inches (4 to 8 centimeters) across. NASA reports: The mission has spotted small patches of these geometric shapes several times before, but nothing at the scale discovered in Valle Grande. In a 360-degree panorama that the rover captured on June 19 and 20, the 4,930th and 4,931st Martian days, or sols, of the mission, the polygonal shapes spread in all directions for as far as the rover can see... "[T]his sea of polygons took our breath away," said the mission's project scientist, Ashwin Vasavada of NASA's Jet Propulsion Laboratory in Southern California... Some of the polygons that the mission has spotted in the past clearly formed as mud cracks, though a variety of processes can contribute to their honeycomb textures, including cycles of warm and cold temperatures or compression that squeezed water out of the sediment when the surface was buried.

These newly discovered polygons are among the many surprises Curiosity has trundled across since landing on Mars 14 years ago, on Aug. 5, 2012. Besides sulfur crystals, shiny meteorites, and other interesting geologic features, the rover has made major discoveries about the ancient Martian environment — most importantly, that it had the water, chemistry, and nutrients to support microbial life.

Billions of years ago, lakes and streams dappled the lower foothills of Mount Sharp, a 3-mile-tall (5-kilometer-tall) mountain that Curiosity has been ascending since 2014. The rover has previously uncovered chemistry left over from Mars' watery history, including carbon-based molecules believed to be precursors to RNA and DNA, two nucleic acids that carry genetic information. Scientists have no way of knowing whether these organic molecules were created by biologic or geologic processes — either path is possible — but their discovery reconfirmed that ancient Mars had the right chemistry to support life.
Dark, pebble-sized rocks also litter the area, NASA writes in a blog post, saying it's a "still-to-be-resolved question" as to whether they're bits of Mars that "floated" down from higher in the sediment layers, or "were ejected from distant impacts outside of Gale crater, or are meteorites from beyond Mars altogether."

"Space.com and The Guardian are reporting that the Falcon 9 upper stage leftover from the launch of the Firefly Blue Ghost-1 lander on Jan. 15, 2025 is due to impact the Moon on Aug. 5, 2026," writes longtime Slashdot reader fahrbot-bot. From a report: Onboard the same flight was the Hakuto-R Mission 2, called Resilience, a robotic lunar lander developed by the Japanese company ispace. According to a new study by an international team, the resulting impact plume may briefly be bright enough to see against the dark sky near the moon's edge. That means it might be visible to moongazers with sufficiently sensitive telescopes. This head-on collision of the errant stage is expected to occur near the Einstein and Bell craters near the western lunar limb. It may well be visible to ground and space-based assets.

Using special physics simulations to model the impact, William Jo, a graduate research assistant at the University of Texas, Austin and colleagues predict the debris plume from the impact will have the central ejecta spike reaching roughly 47 miles to over 60 miles (75 kilometers to 100 kilometers) altitude. "Our calculations suggest the plume should be several orders of magnitude brighter than the dark-sky background for the first few minutes after impact," Jo told Space.com. "So the plume should be visible, though I'd stress this is a single nominal case. The real one will look different, and the numbers are on the optimistic side. But the point worth making is that the flash isn't really the story here." Jo emphasized that there's great slam-dunk science to be had. "Watching this one gives us a rare chance to open up ejecta-plume science and calibrate those models against a real event, which matters for every future thing we deliver to the moon," Jo said.

Google has dismantled the original AlphaFold team, according to Financial Times (paywalled), reassigning many researchers to Gemini and Isomorphic Labs. Several other key members, including Nobel laureate John Jumper, left for Anthropic. Engadget reports: AlphaFold is an AI program that can accurately predict three-dimensional structures of proteins from their amino acid sequences in minutes instead of years. It's now being used to accelerate drug discovery, develop vaccines and understand the structural changes in proteins associated with neurodegenerative diseases like Alzheimer's and Parkinson's.

DeepMind started developing AlphaFold in 2018. In 2020, it was recognized as a solution to humanity's 50-year-old "protein folding problem," which sought to answer how amino acids automatically fold into complex 3D shapes. Those shapes determine the biological role of a protein. Scientists had identified the structures of roughly 170,000 proteins over the past 50 years, using tools and techniques like X-ray and nuclear magnetic resonance. The AlphaFold team took information from those previous work and then fed it to their AI to train AlphaFold.

In 2021, Nature published the papers with AlphaFold's methodology and the structure predictions of the entire human proteome, or the complete set of proteins expressed by our species. DeepMind then launched the AlphaFold Protein Structure Database, giving researchers free access to over 200 million protein structure predictions. In 2024, DeepMind CEO Demis Hassabis and John Jumper, who was a staff research scientist when the project began and who eventually became a VP and engineering fellow, won the Nobel Prize in Chemistry for their work on AlphaFold.

alternative_right shares a report from ScienceAlert: [I]n a new study published in the Journal of Cognitive Neuroscience, researchers from Georgetown University Medical Center in the U.S. have revealed that we can put certain tasks on autopilot in a way that enables something closer to true multitasking. Driving is the perfect example: When you take your test, your entire mental and physical energy is concentrated on executing the right combinations of movements and thoughts. After a decade behind the wheel, the brain is no longer consciously thinking everything through in great detail.

In the new study, the researchers found that after extensive practice, the brain can effectively reroute some tasks around the brain's main computing center -- like a bypass road around a city -- to reduce mental overload and improve multitasking capability. "We have another stepping stone in our understanding of how the brain learns," says neuroscientist Maximilian Riesenhuber, senior author of the study. "The encouraging part is that you really can learn to multitask. There is actually a way to remodel your brain architecture and use other parts of your brain."

[...] "Previous studies have shown that parts of the temporal cortex can be activated by particular object categories in experienced observers -- birds, cars, even Pokemon -- but a limitation of all of those studies is that they only looked after people became experts," says psychologist Patrick Cox, first author of the study. "We measure before and after training, so we can see that extensive training essentially put a category-selective area in the temporal lobe that was not there before." The study culminated in a dual-task experiment, in which the participants were asked to identify cars and take on another challenge. The individuals whose brains had offloaded more car-sorting work to the temporal cortex did better at the second task.

A new analysis of 89 major geological events over the past 260 million years found evidence that mass extinctions, volcanic eruptions, ocean crises, and other upheavals may cluster around a roughly 27.5-million-year cycle. The cause remains unknown, with possibilities ranging from mantle activity and orbital changes to speculative galactic influences. Slashdot reader alternative_right shares a report from ScienceAlert: One possibility lies deep within Earth itself. The planet's mantle is constantly circulating through convection, albeit at an almost unimaginably slow pace. Periodic changes in mantle convection, or the initiation of mantle plumes, could influence volcanism, plate tectonics, mountain building, and other large-scale geological processes. Because these systems are closely interconnected, disturbances originating deep within Earth could eventually ripple through the planet's surface, oceans, climate, and biosphere.

Another hypothesis focuses on interactions between Earth's surface and interior. Long-term orbital variations influence climate and sea level, periodically redistributing enormous amounts of water, ice, and sediment across the planet. [New York University geologist Michael Rampino] discusses the possibility that these changing surface loads subtly modify stresses within Earth's crust and upper mantle, potentially influencing tectonic and volcanic activity over geological timescales.

Rampino also considers possible influences beyond Earth, an idea he has been weighing up since the 1980s. As the Solar System orbits the center of the Milky Way, it oscillates above and below the galaxy's mid-plane, with the timing of these passages aligning with that of Earth's major upheavals. These crossings, other researchers have suggested, could also gravitationally perturb comets in the distant Oort Cloud, increasing the likelihood of large asteroid impacts.

Another, even more speculative, hypothesis suggests that if dark matter is concentrated near the galactic plane, a fraction of it could occasionally be captured by Earth. Over millions of years, this process could generate small amounts of internal heat, potentially influencing geological activity. At present, however, there is no direct evidence supporting either mechanism, so they remain very controversial.

Large asteroid impacts are discussed separately in the paper. Although they were not included in the statistical analysis of the 89 geological events, the timing of several of Earth's largest known impact craters appears broadly consistent with the proposed 27.5-million-year rhythm, as Rampino has discussed in earlier papers. Rampino suggests this correspondence may warrant further investigation, but stops short of claiming a causal relationship.

There's been a change to NASA's launch of six satellites for solar storms research. Space.com reports that those satellites "were originally slated to lift off on a United Launch Alliance Vulcan Centaur rocket but have now been assigned a SpaceX Falcon Heavy, according to a NASA mission update." [NASA's Sun Radio Interferometer Space Experiment mision — or SunRISE] will fly to space as part of a rideshare mission sponsored by the U.S. Space Force's Space Systems Command. Though it's not stated specifically in the NASA release, that may be a hint as to why the mission's rocket was changed. On its most recent launch [U.S. Space Force mission USSF-87], Vulcan experienced an anomaly in one of its solid rocket boosters — the second such incident to occur during the rocket's four launches to date. Vulcan succeeded in delivering the USSF-87 payload to its designated orbit on that launch, but the recurrence of the booster issue during ascent prompted the Space Force to pause national security launches on Vulcan until it could be addressed. Which mission SunRISE will be manifested on has not yet been released, but Space Force's Space Systems Command [SSC] has already shifted other launches between Vulcan and SpaceX's Falcon 9...

Falcon Heavy is SpaceX's heavy-lift launch vehicle... that consists of three modified Falcon 9 first stages, and has launched 12 times since it debuted in 2018. Four of those have delivered national security payloads to orbit, with the most recent of those, USSF-52, launching in December 2023. Falcon Heavy's most recent flight overall occurred this past April, when it sent the Viasat-3 F3 telecom satellite to orbit. Falcon Heavy's next mission will lift off with NASA's Nancy Roman Space Telescope, currently set for no earlier than Aug. 30. SunRISE is scheduled to launch later this year...
Sientists will use data collected by the satellites "to improve prediction models for impending space weather, which in turn could lead to mitigation plans to better thwart the effects of such solar events on orbital infrastructure."

Thanks to long-time Slashdot reader schwit1 for sharing the article.

"Welcome home!" NASA posted on X.com, sharing footage of a successful "parachute-assisted" landing on a Kazakhstan steppe for the Soyuz MS-28, carrying three astronauts who'd spent 241 days on the International Space Station. (And YouTube has a full two-hour video with NASA's coverage of the landing.)

A NASA web page notes they orbited Earth 3,856 times and traveling more than 102 million miles after docking with the Space Station on November 27. It was the first mission for NASA astronaut Chris Williams and Roscosmos cosmonaut Sergei Mikaev (and the second mission for Roscosmos cosmonaut Sergey Kud-Sverchkov). "After routine post-landing medical checks, recovery teams will fly the crew by helicopter to Karaganda, Kazakhstan. Williams then will board a NASA aircraft bound for the agency's Johnson Space Center in Houston."