After 49 years of space travel, Voyager 1 "is running out of power," reports NPR: The spacecraft runs on a radioisotope thermoelectric generator — a device that converts heat from decaying plutonium into electricity. It carries no solar panels, no rechargeable batteries. Just the slow, steady release of nuclear warmth, which diminishes by about 4 watts each year. After nearly five decades, that decline has become critical.

During a routine maneuver in late February, Voyager 1's power levels fell unexpectedly, bringing the probe dangerously close to triggering an automatic fault-protection shutdown — a self-preservation response that would have forced engineers into a lengthy and risky recovery process. The team needed to act first. On April 17, mission engineers sent a sequence of commands to deactivate the Low-energy Charged Particles experiment, known as the LECP, which is one of Voyager 1's remaining science instruments. The LECP has measured ions, electrons, and cosmic rays originating from both our solar system and the galaxy beyond it, helping scientists map the structure of interstellar space in a way no other instrument could...

Voyager 1 now carries two operational science instruments: one that listens for plasma waves, and one that measures magnetic fields. Engineers believe the latest shutdown could buy the mission roughly another year of breathing room. The team is also developing a more sweeping power conservation plan they informally call "the Big Bang" — a coordinated swap of several powered components all at once, trading older systems for lower-power alternatives. If testing on Voyager 2, planned for May and June 2026, goes well, the same procedure will be attempted on Voyager 1 no sooner than July. If it works, there is even a slim chance the LECP could once more continue to work.

The engineers say they hope to keep at least one instrument operating on each spacecraft into the 2030s. It would leave both still reporting from places no machine has ever gone before.111
Voyager 1 is now 15 billion miles from Earth, the article points out. (Radio signals take 23 hours to arrive...)

Thanks to long-time Slashdot reader fahrbot-bot for sharing the article.

NBC News reports on a 16-person clinical trial of "personalized messenger RNA vaccines" which use the immune system to fight cancer cells. "The goal is not to eliminate existing tumors, but instead to stamp out lingering, undetected cancer cells, and later any new cells that form before they can cause a recurrence." Patients still have surgery to remove tumors. After that, the mRNA vaccines are personalized for each individual using genetic material taken from their unique tumor cells. In the clinical trial, after getting the vaccine, the patients also received chemotherapy, which is standard post-op treatment for operable pancreatic cancer... [The article notes that less than 13% of people diagnosed with pancreatic cancer live for more than five years, making it "one of the deadliest cancers."]

[E]xperts have long believed that people with pancreatic cancer could not generate an immune response against tumors. But after nine doses of the personalized vaccine, [clinical trial participant Donna] Gustafson is one of eight people in the 16-person Phase 1 trial who did just that, producing an army of immune cells called T cells that seek out and destroy tumor cells... [Dr. Vinod Balachandran, a vaccine center director who is leading the trial, said] it was unclear whether the immune response would last and lead to the patients living longer... New data collected during the trial's six-year follow-up period shows that it may. Those findings will be presented Monday at the American Association for Cancer Research's annual meeting in San Diego. Six years after treatment, Gustafson and six others who responded to the treatment are still alive...

More research is still needed. Genentech and BioNTech, the two drugmakers behind the vaccine, have already launched a larger Phase 2 clinical trial... Another team is working on an off-the-shelf vaccine that targets a protein called KRAS that is present in as many as 90% of pancreatic cancers. In a small, early trial, about 85% of the participants mounted an immune response to the protein.

After Artemis II's astronauts returned to earth, "NASA has Artemis III in its sights," reports the Associated Press: In a mission recently added to the docket for next year, Artemis III's yet-to-be -named astronauts will practice docking their Orion capsule with a lunar lander or two in orbit around Earth. Elon Musk's SpaceX and Jeff Bezos' Blue Origin are racing to have their company's lander ready first. Musk's Starship and Bezos' Blue Moon are vying for the all-important Artemis IV moon landing in 2028. Two astronauts will aim for the south polar region, the preferred location for [NASA Administrator Jared] Isaacman's envisioned $20 billion to $30 billion moon base. Vast amounts of ice are almost certainly hidden in permanently shadowed craters there — ice that could provide water and rocket fuel.

The docking mechanism for Artemis III's close-to-home trial run is already at Florida's Kennedy Space Center. The latest model Starship is close to launching on a test flight from South Texas, and a scaled-down version of Blue Moon will attempt a lunar landing later this year.

Slashdot reader smazsyr writes: A new review says we've had fructose wrong for decades. The nine authors, led by Richard Johnson at the University of Colorado Anschutz, argue that fructose "is not just another calorie." It is a signal. It tells the liver to make fat and brace for a famine that never comes. That made sense for a bear fattening up on autumn berries. It makes less sense for a person drinking soda in March.

The review reframes the WHO's sugar guideline, argues ScienceBlog.com, as "less a recommendation about calories and more a warning about a signalling molecule we have been dosing ourselves with, several times a day, for most of a century."

NASA has revived support for the European Space Agency's long-delayed Rosalind Franklin Mars rover mission. According to the space agency, the current plan is to launch via a SpaceX Falcon Heavy no earlier than 2028. Engadget reports: This is a partnership between NASA and the ESA, with the European agency providing the rover, the spacecraft and the lander. The US will provide braking engines for the lander, heater units for the rover's internal systems and, of course, assistance with the actual launch.

The rover will be outfitted with scientific instruments to look for signs of ancient life on the red planet. These include a state-of-the-art mass spectrometer and an organic molecule analyzer, which will come in handy as the vehicle collects samples at the Oxia Planum landing site. The mission has been stuck in development limbo since 2001, with delays caused by budget problems, technical issues, shifting international partners, and geopolitical fallout. After NASA dropped out, Russia stepped in, then was cut loose after invading Ukraine, and now -- despite NASA rejoining in 2024 and fresh political budget threats -- the rover is tentatively back on track for a 2028 launch.

An anonymous reader quotes a report from the Guardian: The critical Atlantic current system appears significantly more likely to collapse than previously thought after new research found that climate models predicting the biggest slowdown are the most realistic. Scientists called the new finding "very concerning" as a collapse would have catastrophic consequences for Europe, Africa and the Americas. The Atlantic meridional overturning circulation (Amoc) is a major part of the global climate system and was already known to be at its weakest for 1,600 years as a result of the climate crisis. Scientists spotted warning signs of a tipping point in 2021 and know that the Amoc has collapsed in the Earth's past.

Climate scientists use dozens of different computer models to assess the future climate. However, for the complex Amoc system, these produce widely varying results, ranging from some that indicate no further slowdown by 2100 to those suggesting a huge deceleration of about 65%, even when carbon emissions from fossil fuel burning are gradually cut to net zero. The research combined real-world ocean observations with the models to determine the most reliable, and this hugely reduced the spread of uncertainty. They found an estimated slowdown of 42% to 58% in 2100, a level almost certain to end in collapse.

The Amoc is a major part of the global climate system and brings sun-warmed tropical water to Europe and the Arctic, where it cools and sinks to form a deep return current. A collapse would shift the tropical rainfall belt on which many millions of people rely to grow their food, plunge western Europe into extreme cold winters and summer droughts, and add 50-100cm to already rising sea levels around the Atlantic. The slowdown has to do with the Arctic's rapidly rising temperatures from global warming. "Warmer water is less dense and therefore sinks into the depths more slowly," explains the Guardian. "This slowing allows more rainfall to accumulate in the salty surface waters, also making it less dense, and further slowing the sinking and forming an Amoc feedback loop."

The new research has been published in the journal Science Advances.

An anonymous reader quotes a report from Ars Technica: On Thursday, OpenAI announced it had developed a large language model specifically trained on common biology workflows. Called GPT-Rosalind after Rosalind Franklin, the model appears to differ from most science-focused models from major tech companies, which have generally taken a more generic approach that works for various fields. In a press briefing, Yunyun Wang, OpenAI's Life Sciences Product Lead, said the system was designed to tackle two major roadblocks faced by current biology researchers. One is the massive datasets created by decades of genome sequencing and protein biochemistry, which can be too much for any one researcher to take in. The second is that biology has many highly specialized subfields, each with its own techniques and jargon. So, for example, a geneticist who finds themselves working on a gene that's active in brain cells might struggle to understand the immense neurobiological literature.

Wang said the company had taken an LLM and trained it on 50 of the most common biological workflows, as well as on how to access the major public databases of biological information. Further training has resulted in a system that can suggest likely biological pathways and prioritize potential drug targets. "We're connecting genotype to phenotype through known pathways and regulatory mechanisms, infer likely structural or functional properties of proteins, and really leveraging this mechanistic understanding," Wang said. To address LLMs' tendencies toward sycophancy and overenthusiasm, OpenAI says it has tuned the model to be more skeptical, so it's more likely to tell you when something is a bad drug target. There was a lot of talk about GPT-Rosalind's "reasoning" and "expert-level" abilities. We were told that the former was defined as being able to work through complex, multi-step processes, while the latter was derived from the model's performance on a handful of benchmarks. Access to GPT-Rosalind is currently limited "due to concerns about the model's potential for harmful outputs if asked to do something like optimize a virus's infectivity," notes Ars. Only U.S.-based organizations can request access at the moment.

An anonymous reader quotes a report from the Guardian: We may appear to have little in common with sperm whales – enormous, ocean-dwelling animals that last shared a common ancestor with humans more than 90 million years ago. But the whales' vocalized communications are remarkably similar to our own, researchers have discovered. Not only do sperm whale have a form of "alphabet" and form vowels within their vocalizations but the structure of these vowels behaves in the same way as human speech, the new study has found.

Sperm whales communicate in a series of short clicks called codas. Analysis of these clicks shows that the whales can differentiate vowels through the short or elongated clicks or through rising or falling tones, using patterns similar to languages such as Mandarin, Latin and Slovenian. The structure of the whales' communication has "close parallels in the phonetics and phonology of human languages, suggesting independent evolution," the paper, published in the Proceedings B journal, states. Sperm whale coda vocalizations are "highly complex and represent one of the closest parallels to human phonology of any analyzed animal communication system," it added.

[...] The new study shows that "sperm whale communication isn't just about patterns of clicks -- it involves multiple interacting layers of structure," said Mauricio Cantor, a behavioral ecologist at the Marine Mammal Institute who was not involved in the research. "With this study, we're starting to see that these signals are organized in ways we didn't fully appreciate before." The latest discovery around sperm whale speech has inched forward the possibility of someday fully understanding the creatures and even communicating with them. Project CETI has set a goal of being able to comprehend 20 different vocalized expressions, relating to actions such as diving and sleeping, within the next five years. A future where we're able to fully understand what the whales are saying and be able to have a conversation with them is "totally within our grasp," said David Gruber, founder and president of Project CETI. "We've already got a lot further than I thought we could. But it will take time, and funding. At the moment we are like a two-year-old, just saying a few words. In a few years' time, maybe we will be more like a five-year-old."

An anonymous reader quotes a report from UploadVR: A group of independent researchers built a device that can artificially induce smell using ultrasound, with no consumable cartridges required. [...] The team of four are Lev Chizhov, Albert Yan-Huang, Thomas Ribeiro, Aayush Gupta. Chizhov is a neurotech entrepreneur with a background in math and physics, Yan-Huang is a researcher at Caltech with a background in computation and neural systems, and Ribeiro and Gupta are co-researchers on the project with software engineering and AI expertise.

Instead of targeting your nose at all, the device directly targets the olfactory bulb in your brain with "focused ultrasound through the skull." The researchers say that as far as they're aware, no one has ever done this before, even in animals. A challenge in targeting the olfactory bulb is that it's buried behind the top of your nose, and your nose doesn't provide a flat surface for an emitter. Ultrasound also doesn't travel well through air. The solution the researchers came up with was to place the emitter on your forehead instead, with a "solid, jello-like pad for stability and general comfort," and the ultrasound directed downward towards the olfactory bulb.

To determine the best placement, they say they used an MRI of one of their skulls to "roughly determine where the transducer would point and how the focal region (where ultrasound waves actually concentrate) aligned with the olfactory bulb (the target for stimulation)". [...] According to the researchers, they were able to induce the sensation of fresh air "with a lot of oxygen", the smell of garbage "like few-day-old fruit peels," an ozone-like sensation "like you're next to an air ionizer," and a campfire smell of burning wood. While technically head-mounted, the current device does require being held up with two hands. But as with all such prototypes, it likely could be significantly miniaturized.

An anonymous reader quotes a report from the New York Times: Many scientists have contended that humans have evolved very little over the past 10,000 years. A few hundred generations was just a blink of the evolutionary eye, it seemed. Besides, our cultural evolution -- our technology, agriculture and the rest -- must have overwhelmed our biological evolution by now. A vast study, published on Wednesday in the journal Nature, suggests the opposite. Examining DNA from 15,836 ancient human remains, scientists found 479 genetic variants that appeared to have been favored by natural selection in just the past 10,000 years.

The researchers also concluded that thousands of additional genetic variants have probably experienced natural selection. Before the new study, scientists had identified only a few dozen variants. "There are so many of them that it's hard to wrap one's mind around them," said David Reich, a geneticist at Harvard Medical School and an author of the new study. He and his colleagues found that a mutation that is a major risk factor for celiac disease, for example, appeared just 4,000 years ago, meaning the condition may be younger than the Egyptian pyramids. The mutation became ever more common. Today, an estimated 80 million people worldwide have celiac disease, in which the immune system attacks gluten and damages the intestines.

The steady rise of the mutation came about through natural selection, the scientists argue. For some reason, people with the mutation had more descendants than people without it -- even though it put them at risk of an autoimmune disorder. Other findings are even more puzzling. The researchers found that genetic variants that raise the odds of a smoking habit have been getting steadily rarer in Europe for the past 10,000 years. Something is working against those variants -- but it can't be the harm from smoking. Europeans have been smoking tobacco for only about 460 years. The scientists can't see from their research so far what forces might be making these variants more or less common. "My short answer is, I don't know," said Ali Akbari, a senior staff scientist at Harvard and an author of the study. The researchers also found that some variants, like the one linked to Type B blood, became much more common in Europe around 6,000 years ago, while others changed direction over time. For example, a TYK2 immune gene variant that may have once been beneficial later became harmful because it increased tuberculosis risk.

The study also found signs of natural selection in 44 out of 563 traits. Variants linked to Type 2 diabetes, wider waists, and higher body fat have become less common, possibly because farming and carbohydrate-heavy diets made once-useful fat-storing traits more harmful. Other findings, such as selection favoring genes linked to more years of schooling, are harder to interpret.

A 63-year-old man in Norway appears to be cured of HIV after receiving a stem cell transplant from his brother, who turned out to have a rare mutation that makes immune cells resistant to HIV. "Four years after the transplant, and two years after the man stopped antiretroviral therapy, he still appears to be free of the infection," reports Gizmodo. From the report: According to the report, the man was first diagnosed with myelodysplastic syndrome, a type of cancer that weakens blood cell production from bone marrow, in 2018. Though he seemed to initially respond to treatment, the cancer returned after two years, and doctors decided to perform a stem cell transplant. Because the man also had HIV (diagnosed in 2006), the doctors were hoping to treat both conditions at once, though they knew their chances were low. Most of these cases have involved the use of stem cells taken from people with two copies of a particular mutation in their CCR5 gene, which regulates the CC5R receptor on white blood cells. This mutation, named CCR5-delta 32, makes immune cells naturally resistant to infection from strains of HIV-1 (the most common type of the virus). However, only about 1% of the population carries two copies of the mutation.

After initial screening failed to find someone who both possessed the mutation and had compatible bone marrow, the doctors decided to move ahead with the man's brother, who was already known to have compatible bone marrow. But to everyone's surprise, testing on the day of the transplant showed that the brother also had the mutation. Though the man did experience some complications from the procedure, his body successfully started to produce new blood cells with the mutation. The doctors decided to take him off antiretroviral medication two years after the transplant. And in the two years since then, regular follow-up tests have failed to show any signs of the virus in his system. [...] According to AFP, there have only been roughly 10 cases worldwide involving an HIV cure through stem cell transplantation. This is the first to involve a family donor.

Researchers at the University of Southern California say they've developed a memristor memory device that continued operating at 700 degrees Celsius. "And crucially, 700 degrees was not the limit, it was simply as hot as their testing equipment could go," adds ScienceAlert. "The device showed no signs of failing." From the report: The device is called a memristor and it's a nanoscale component that can both store information and perform computing operations. Think of it as a tiny sandwich with two electrode layers on the outside and a thin ceramic filling in the middle. The team built theirs from tungsten, the metal with the highest melting point of any element, combined with a ceramic called hafnium oxide, and with a layer of graphene at the bottom. Each material can withstand enormous heat. Together, they turned out to be extraordinary.

What makes graphene the key ingredient is the way it interacts with tungsten at the atomic level. In a conventional device, heat causes metal atoms to drift slowly through the ceramic layer until they bridge the two electrodes, short circuiting everything and leaving the device permanently broken. Graphene stops that process dead. Its surface chemistry with tungsten is ... almost like oil and water. Tungsten atoms that drift toward the graphene find they simply cannot take hold, no anchor, no short circuit, no failure. The team used advanced electron microscopy and quantum level computer simulations to understand exactly why, turning a single lucky result into a repeatable principle. The findings have been published in the journal Science.

The biotech industry's engineered cells could become an $8 trillion market by 2035, notes Phys.org. But how do you keep them from being stolen? Their article notes "an uptick in the theft and smuggling of high-value biological materials, including specially engineered cells." In Science Advances, a team of U.S. researchers present a new approach to genetically securing precious biological material. They created a genetic combination lock in which the locking or encryption process scrambled the DNA of a cell so that its important instructions were non-functional and couldn't be easily read or used. The unlocking, or decryption, process involves adding a series of chemicals in a precise order over time — like entering a password — to activate recombinases, which then unscramble the DNA to their original, functional form...

They created a biological keypad with nine distinct chemicals, each acting as a one-digit input. By using the same chemicals in pairs to form two-digit inputs, where two chemicals must be present simultaneously to activate a sensor, they expanded the keypad to 45 possible chemical inputs without introducing any new chemicals. They also added safety penalties — if someone tampers with the system, toxins are released — making it extremely unlikely for an unauthorized person to access the cells.
"The researchers conducted an ethical hacking exercise on the test lock and found that random guessing yielded a 0.2% success rate, remarkably close to the theoretical target of 0.1%."

"Breathable oxygen has been created from Moon dust," reports the Telegraph, "in a world first that paves the way for a lunar base."

Jeff Bezos's Blue Origin ""announced this week that it had developed a reactor that could successfully release oxygen from lunar soil by using an electric current." Almost half of Moon dust — the thin layer of rock that blankets the lunar surface — is oxygen, but it is bound to metals such as iron and titanium... Previous work to isolate oxygen has been lab-based, and the unwieldy equipment needed has been too difficult to send to the Moon. In contrast, Blue Origin said its small-scale reactor, named Air Pioneer, could be made flight-ready to "provide the first breath of life for a sustainable Moon base"... As well as breathable air, Blue Origin said the reactor produces other critical elements for planetary infrastructure, such as iron, aluminium and silicon for construction and electronics, as well as glass for windows and solar panel covers. The company has previously said it wants to turn the Moon, and eventually Mars, into "self-sustaining worlds where robots and humans can go beyond visiting and truly explore, grow, live, and thrive"....

Blue Origin said it would need to generate around one megawatt of power to drive the reactors — about the energy it would require to power around 400 to 1,000 homes simultaneously. It envisages that each lunar settlement would have an array of nearby solar panels, generating the power needed for one reactor.
Besides breathable air for astronauts, the oxygen could also be used in propellant for refuelling landers and fuel cells, Blue Origin points out — and "produced right where they're needed, and at much lower cost than being brought from Earth."

Thanks to Slashdot reader fjo3 for sharing the article.

Critics say social media is engineered to be as addictive as tobacco or gambling, writes the Washington Post — while adding that "the science has been moving in parallel with the court's recognition." A growing body of research links heavy social media use not only to declines in mental health but to measurable cognitive effects — on attention, memory and focus — that in some studies resemble accelerated aging. Science also suggests we have more control than we realize when it comes to reversing this damage, and the solution is surprisingly simple: Take a break... "Digital detoxes" can sound like a fad. But in one of the largest studies to date, published in PNAS Nexus and involving more than 467 participants with an average age of 32, even a short time away produced striking results — effectively erasing a decade of age-related cognitive decline.

For 14 days, participants used a commercially available app, Freedom, to block internet access on their phones. They were still allowed calls and text messages, essentially turning a smartphone into a dumb phone. Their time online decreased from 314 minutes to 161 minutes, and by the end of the period the participants had improvements in sustained attention, mental health as well as self-reported well-being. The improvement in sustained attention was about the same magnitude as 10 years of age-related decline, the researchers noted, and the effect of the intervention on depression symptoms was larger than antidepressants and similar to that of cognitive behavioral therapy.

But two things were even more mind-blowing... Even those people who cheated and broke the rules after a few days seemed to have positive effects from the break; and in follow-up reports after the two weeks, many people reported the positive effects lingered. "So you don't have to necessarily restrict yourself forever. Even taking a partial digital detox, even for a few days, seems to work," Kushlev said.
The article also notes a November study at Harvard published in JAMA Network Open where nearly 400 people 'found that even a short break can make a measurable difference: After just one week of reduced smartphone use, participants reported drops in anxiety (16.1 percent), depression (24.8 percent) and insomnia (14.5 percent)..."

"Other experiments point in the same direction — whether decreasing social media use by an hour a day for one week or stepping away from just Facebook and Instagram."