Science

Former NASA Engineers Create Ingenious Way To Save Homes From Wildfires Using Noise (nypost.com) 32

"Scientists have created a miraculous new way to stop fires from spreading through neighborhoods using nothing but sound," reports the New York Post: Former NASA engineers with California-based Sonic Fire Tech found that using sound waves can snuff out blazes and potentially be used to stop another Pacific Palisades inferno... The technology works by targeting oxygen molecules using low-frequency sound waves that vibrate them, stopping the fire from growing. "Sound waves vibrate the oxygen faster than the fuel can use it, and break the chemical reaction of the flame," Remington Hotchkis, Chief Commercialization Officer at Sonic Fire Tech told The Post.

The San Bernardino County Fire Department recently tested out the equipment using a backpack version and the results were incredible. Video shows firefighters fighting small blazes on a shrub and a stove top fire with the technology putting it out... In the home application, the system would be alerted/activated if there was a fire, sending the sound waves through a home duct system, essentially snuffing out the blaze. The sound waves can reach as far as 30ft from a home, the report noted. The sound is also harmless to pets and humans.

The article includes this quote that an executive at the company gave local news station KMPH. "Our former NASA engineers are rocket scientists, and they say it seems like magic, but it's just physics."
AI

An Amateur Just Solved a 60-Year-Old Math Problem - by Asking AI (scientificamerican.com) 57

Slashdot reader joshuark writes: Scientific American reports that a ChatGPT AI has proved a conjecture with a method no human had developed. A 23-year-old student Liam Price just cracked a 60-year-old problem that world-class mathematicians have tried and failed to solve.

The new solution that Price got in response to a single prompt to GPT-5.4 Pro was posted on www.erdosproblems.com, a website devoted to the Erds problems. The question Price solved — or prompted ChatGPT to solve—concerns special sets of whole numbers, where no number in the set can be evenly divided by any other...

Price sent it to his occasional collaborator Kevin Barreto, a second-year undergraduate in mathematics at the University of Cambridge. The duo had jump-started the AI-for-Erds craze late last year by prompting a free version of ChatGPT with open problems chosen at random from the Erds problems website. Reviewing Price's message, Barreto realized what they had was special, and experts whom he notified quickly took notice.

Medicine

Retina Scan for Diabetes Could Also Reduce Deaths During Pregnancy in Developing Countries (gatesnotes.com) 17

This week Bill Gates wrote a blog post about a special camera from medtech startup Remidio, which delivers high-resolution images of a patient's retina in seconds. The camera plugs into a phone running an AI system that watches for early signs of diabetes — all without needing a blood draw, eye dilation, or a dibetes specialist. It's already been used in 40 countries for more than 15 million patients. But that same hardware, with different software, can also flag the conditions that drive so many dangerous pregnancies. Gestational diabetes sharply increases the risk of pre-eclampsia [a spike in blood pressure during pregnancy responsible for half a million fetal deaths every year and 70,000 maternal deaths]... In most of rural sub-Saharan Africa or South Asia, it usually isn't screened for at all, because the standard test requires a lab. A retinal scan offers a different way in.

Remidio's device is currently being used in India to screen pregnant women for conditions that drive stillbirth. And researchers are now adapting the same hardware to screen for anemia and hypertension, too... [S]mall, portable, affordable diagnostics in the hands of community health workers are exactly the kind of lever that can start to move a number that hasn't moved in a long time.

Mars

New Lithium-Plasma Engine Passes Key Mars Propulsion Test (universetoday.com) 38

NASA engineers have tested a next-generation lithium-plasma electric propulsion system that reached 120 kilowatts, a new U.S. record and about 25 times the power of the electric thrusters on NASA's Psyche spacecraft. "Designing and building these thrusters over the last couple of years has been a long lead-up to this first test," said James Polk, who is a senior research scientist at NASA Jet Propulsion Laboratory. "It's a huge moment for us because we not only showed the thruster works, but we also hit the power levels we were targeting. And we know we have a good testbed to begin addressing the challenges to scaling up." Universe Today reports: While 120 kilowatts is a new record, NASA estimates it a future human mission to Mars will require 2 to 4 megawatts of power consisting of several thrusters and requiring more than 23,000 hours (958 days/2.6 years) of operation. To accomplish this, the thrusters would have to withstand more than 2,800 degrees Celsius (5,000 degrees Fahrenheit), which the thrusters achieved during testing.

The reason for the extended operation is due to the estimated time of an entire human mission to Mars, which is estimated to be approximately 2.6 years. This is because the launch window to Mars only opens once every two years due to the orbital behaviors of both planets. While no mission has ever returned from the Red Planet, this same launch window works from Mars to Earth, too. When launched within this window, robotic spacecraft have traditionally taken approximately 6-7 months to reach Mars.

However, a human mission would require a much larger spacecraft to accommodate the astronauts, food, fuel, water, and other mission-essential items. For the approximate 2.6-year mission, this would entail approximately 6-9 months traveling to Mars, followed by approximately 18 months on the surface of Mars until the next launch window opens, then another approximate 6-9 months back to Earth. However, having much less fuel due to the electric propulsion system could potentially alter this timeframe.

Medicine

In Real-World Test, an AI Model Did Better Than ER Doctors At Diagnosing Patients 81

A new study from Harvard Medical School and Beth Israel Deaconess found that an OpenAI reasoning model outperformed experienced ER doctors at diagnosing and managing patient cases using messy, real-world emergency department records. Researchers say the results don't support replacing doctors, but they do suggest AI could meaningfully reshape clinical workflows if tested carefully in prospective trials. NPR reports: The researchers ran a series of experiments on the AI model to test its clinical acumen -- including actual cases like the lupus patient who'd been previously treated at the emergency department at Beth Israel in Boston. The team graded how well the AI model could provide an accurate diagnosis at three moments in time, from the triage stage in the ER, up to being admitted into the hospital. Overall, AI outperformed two experienced physicians -- and did so with only the electronic health records and the limited information that had been available to the physicians at the time. "This is the big conclusion for me -- it works with the messy real-world data of the emergency department, " said Dr. Adam Rodman, a clinical researcher at Beth Israel and one of the study authors. "It works for making diagnoses in the real world."

Other parts of the study focused on case reports published in the New England Journal of Medicine and clinical vignettes to suss out whether the AI model could meet well-established "benchmarks" and game out thorny diagnostic questions. "The model outperformed our very large physician baseline," said Raj Manrai, assistant professor of Biomedical Informatics at Harvard Medical School who was also part of the study. The authors emphasize the AI relied on text alone, while in real life, clinicians need to attend to many other inputs like images, sounds and nonverbal cues when diagnosing and treating a patient.
The findings have been published Thursday in the journal Science.
China

Convicted Former Harvard Scientist Rebuilds Brain Computer Lab In China (reuters.com) 72

Reuters reports that Charles Lieber, the former Harvard scientist convicted of lying to U.S. authorities about payments and ties to China, is now leading China's state-funded i-BRAIN lab in Shenzhen, where he has access to advanced nanofabrication tools and primate research facilities for brain-computer interface work. From the report: Charles Lieber, 67, is among the world's leading researchers in brain-computer interfaces. The technology has shown promise in treating conditions such as ALS and restoring movement in paralyzed patients. But it also has potential military applications: Scientists at China's People's Liberation Army have investigated brain interfaces as a way to engineer super soldiers by boosting mental agility and situational awareness, according to the U.S. Defense Department. Lieber was found guilty by a jury and convicted in December 2021 of making false statements to federal investigators about his ties to a Chinese state program to recruit overseas talent, and tax offenses related to payments he received from a Chinese university. He served two days in prison and six months under house arrest, and was fined $50,000 and ordered to pay $33,600 in restitution to the Internal Revenue Service. During the case, his defense said he was suffering from an incurable lymphoma, which was in remission, and he was fighting for his life.

Three years after he was sentenced, Reuters has learned that Lieber is now overseeing China's state-funded i-BRAIN, or the Institute for Brain Research, Advanced Interfaces and Neurotechnologies, with access to dedicated nanofabrication equipment and primate research infrastructure unavailable to him at Harvard. The lab is an arm of the Shenzhen Medical Academy of Research and Translation, or SMART. "I arrived on April 28, 2025 with a dream and not much more, maybe a couple bags of clothes," Lieber said of his move to China at a Shenzhen government conference in December. "Personally, my own goals are to make Shenzhen a world leader."

SMART last year appointed Lieber as an investigator, according to a post on i-BRAIN's website dated May 1, 2025. That news was covered by some media outlets. The same day, i-BRAIN said Lieber had also been appointed its founding director -- an announcement that went unreported at the time. This story is the most comprehensive account of Lieber's activities since he moved to China. Reuters is reporting for the first time that his lab has access to dedicated primate research facilities and chip-making equipment; that it sits within a sprawling ecosystem of state-backed institutions bankrolled by billions of dollars in government funding; and that it is housed within an institution that is luring top scientific talent back from the United States.

Education

Should Schools Get Rid of Homework? (npr.org) 190

Tony Isaac shares a report from NPR: Federal survey data shows that the amount of math homework assigned to fourth and eighth grade students, in particular, has been steadily declining for the past decade. Some educators and parents say this is a good thing -- students shouldn't spend six or more hours a day at school and still have additional schoolwork to complete at home. But the research on homework is complicated. Some studies show that students who spend more time on homework perform better than their peers. For example, a longitudinal study released in 2021 of more than 6,000 students in Germany, Uruguay and the Netherlands found that lower-performing students who increased the amount of time they spent on math homework performed better in math, even one year later.

Other studies, however, suggest homework has minimal outcomes on academic performance: A 1998 study of more than 700 U.S. students led by a researcher at Duke University found that more homework assigned in elementary grades had no significant effect on standardized test scores. The researchers did find small positive gains on class grades when they looked at both test scores and the proportion of homework students completed. More homework was also associated with negative attitudes about school for younger children in the study. "The best educators figured out a long time ago that we can control what we can control," and that's what happens during the school day, Superintendent Garrett said, not homework. "There has been a shift away from it naturally anyway, and I felt like this made it equitable across our entire school system."
"The best argument for homework is that mathematical procedures require practice, and you don't want to waste classroom time on practice, so you send that home," said Tom Loveless, a researcher and former teacher who has studied homework.

Ariel Taylor Smith, senior director of the Center for Policy and Action at the National Parents Union, said: "The thing they point to is that it's an equity issue, and not all parents have the same availability and ability to support their students. I would make the argument that if a kid is really far behind in school, that's an equity issue. They need the additional time to practice." Kids, she said, "need more practice ... Sometimes, you do have to practice the boring stuff, like math."

"The interesting issue for folks to consider is not should there be more homework, but should there be better homework," said Joyce Epstein, who has studied homework and is the co-director of the Center on School, Family, and Community Partnerships at the Johns Hopkins University School of Education. "Better homework in math might be knowing the fact that kids don't have to be practicing for hours, 10 to 20 examples," when they could establish mastery in less time.
Medicine

FDA Grants Quick Review For 3 Psychedelic Drug Trials 56

An anonymous reader quotes a report from NBC News: The Food and Drug Administration on Friday granted a quick review of three experimental psychedelic drugs meant to treat major depression and post-traumatic stress disorder. It's the latest move by the Trump administration signaling a shift in policy toward treatments that also give users a high -- coming a day after the Justice Department said it would ease restrictions on state-licensed medical marijuana.

UK-based biotech company Compass Pathways said Friday it has received an expedited review for its experimental form of synthetic psilocybin for treatment-resistant depression. In a press release the company cited two large, phase 3 studies that had "generated positive data." Usona Institute, headquartered in Wisconsin, also said it's received a voucher for its work with psilocybin to treat major depressive disorder. In an email, a Usona spokesperson said the company expects the review process to last one to two months after it submits its application. "The voucher expedites the timeline only; it does not alter scientific or regulatory standards," the spokesperson wrote. New York-based Transcend Therapeutics has also been granted a priority review voucher for its experimental drug methylone for PTSD, Blake Mandell, the company's chief executive officer, said.
"There's a battle still raging in their mind that we don't fully understand biochemically," FDA Commissioner Marty Makary said. "When you see something that looks promising for a community that is suffering with mental health illness, despair and suicidal ideation, you can't help but recognize that."

Makary told NBC News that with the priority voucher program, the agency could potentially approve the first psychedelic drug by the end of summer.
Java

Electrical Current Might Be the Key To a Better Cup of Coffee (arstechnica.com) 55

An anonymous reader quotes a report from Ars Technica: University of Oregon chemist Christopher Hendon loves his coffee -- so much so that studying all the factors that go into creating the perfect cuppa constitutes a significant area of research for him. His latest project: discovering a novel means of measuring the flavor profile of coffee simply by sending an electrical current through a sample beverage. The results appear in a new paper published in the journal Nature Communications.

[...] The coffee industry typically uses a method for measuring the refractive index of coffee -- i.e., how light bends as it travels through the liquid -- to determine strength, but it doesn't capture the contribution of roast color to the overall flavor profile. So for this latest study, Hendon decided to focus on roast color and beverage strength, the two variables most likely to affect the sensory profile of the final cuppa. His solution turned out to be quite simple. Hendon repurposed an electrochemical tool called a potentiostat, typically used to test battery and fuel cell performance. Hendon used the tool to measure how electricity interacted with the liquid. He found that this provided a better measurement of the flavor profile. He even tested it on four different samples of coffee beans and successfully identified the distinctive signature of a batch that had failed the roaster's quality-control process.

Granted, one's taste in coffee is fairly subjective, so Hendon's goal was not to achieve a "perfect" cup but to give baristas a simple tool to consistently reproduce flavor profiles more tailored to a given customer's taste. "It's an objective way to make a statement about what people like in a cup of coffee," said Hendon. "The reason you have an enjoyable cup of coffee is almost certainly that you have selected a coffee of a particular roast color and extracted it to a desired strength. Until now, we haven't been able to separate those variables. Now we can diagnose what gives rise to that delicious cup."
Outside of his latest electrical-current experiment, Christopher Hendon's coffee research has shown that espresso can be made more consistently by modeling extraction yield -- how much coffee dissolves into the final drink -- and controlling water flow and pressure.

He also found that static electricity from grinding causes fine coffee particles to clump, which disrupts brewing. The solution: adding a small squirt of water to beans before grinding (known as the Ross droplet technique) to reduce that static, cut clumping and waste, and lead to a stronger, more consistent espresso.
Medicine

Apple Vision Pro Used In World-First Cataract Surgery (macrumors.com) 33

Apple's Vision Pro has been used in what's described as the world's first cataract surgery performed with the headset. MacRumors reports: [New York opthalmologist] Dr. Eric Rosenberg of SightMD completed the initial procedure in October 2025 and has since performed hundreds of additional cases using ScopeXR, a surgical platform he co-developed for Apple's mixed reality device. ScopeXR streams live feeds from 3D digital surgical microscopes directly into the Vision Pro, which lets the surgeon view the operative field in stereoscopic 3D while overlaying preoperative diagnostic data. The platform also supports real-time remote collaboration, allowing surgeons to virtually join procedures and see exactly what the operating surgeon sees. "We are now able to bring the world's best surgeon into any operating room, at any hour, from anywhere on the planet," said Dr. Rosenberg in a company press release. "From residents performing their first cases to surgeons facing unexpected complications, this technology democratizes access to expertise and that will save vision."
The Courts

Supreme Court Hears Case On How To Label Risks of Popular Weed Killer (npr.org) 84

An anonymous reader quotes a report from NPR: A divided U.S. Supreme Court on Monday heard a dispute over labels on the popular Roundup weed killer, which thousands of people blame for their cancers. How the Supreme Court rules could have implications for tens of thousands of lawsuits against Roundup maker Monsanto, which is now owned by Bayer. The case centers on who decides about warning labels on chemicals: the federal government -- or states or juries. [...] The justices will not be evaluating whether glyphosate causes cancer. Rather, they'll consider who should decide what appears on warning labels and whether states have a role to play after the EPA weighs in.

The current U.S. solicitor general backed Monsanto. Sarah Harris, his principal deputy, said the Environmental Protection Agency is in the driver's seat, not anyone in Missouri. "Missouri thus requires adding cancer warnings but federal law requires EPA to approve new warnings and tasks EPA with deciding what label changes would mitigate any health risks," Harris argued. "State law must give way." Several justices, including Brett Kavanaugh, appeared to agree with Monsanto's argument about the need for a single, uniform standard across the country.

But others, like Chief Justice John Roberts, wondered what would happen if the federal government moved more slowly than states did, who wanted to act quickly on information about new dangers. "Well, it does undermine the uniformity," Roberts said. "On the other hand, if it turns out they were right, it might have been good if they had an opportunity to do something, to call this danger to the attention of people while the federal government was going through its process," he said about states.

Justice Ketanji Brown Jackson asked about the emergence of new science, and the EPA's reviews. "There's a 15-year window between when that product has to be re-registered again and lots of things can happen in science, in terms of development about the product," she said. Bayer, which now owns Monsanto, only sells Roundup that contains glyphosate to farmers and businesses these days. Bayer has been pushing to resolve scores of the residential cases through a sweeping settlement, trying to put the costly claims behind it.

Science

The Silent Frequency That Makes Old Buildings Feel Haunted (scienceblog.com) 82

Researchers say infrasound -- low-frequency vibrations from things like pipes, HVAC systems, and traffic that humans can't consciously hear -- may help explain why some old buildings feel unsettling or "haunted." Rodney Schmaltz, senior author and professor at MacEwan, says: "Consider visiting a supposedly haunted building. Your mood shifts, you feel agitated, but you can't see or hear anything unusual. In an old building, there is a good chance that infrasound is present, particularly in basements where aging pipes and ventilation systems produce low-frequency vibrations. If you were told the building was haunted, you might attribute that agitation to something supernatural. In reality, you may simply have been exposed to infrasound." ScienceBlog.com reports: Infrasound sits below roughly 20 Hz, the lower limit of what the human ear can ordinarily detect. It's generated by storms, by volcanic activity, by tectonic rumblings deep in the Earth's crust, and (this is the part that matters) by the mundane mechanical heartbeat of cities: ageing pipes, HVAC systems, traffic, industrial machinery. "Infrasound is pervasive in everyday environments, appearing near ventilation systems, traffic, and industrial machinery," says Schmaltz. Most of the time, we walk through it without a second thought. The question the team wanted to answer was whether walking through it was actually doing something to us, whether the frequency was registered somewhere below consciousness, somewhere we couldn't readily name.

The experimental setup was deliberately ordinary. Thirty-six undergraduate students filed one at a time into isolated testing rooms and sat alone with a piece of music, either a calming instrumental or a horror-themed ambient track designed to provoke discomfort. Hidden subwoofers, including a 12-inch unit positioned in an adjacent hallway and a 16-inch speaker oriented toward the ceiling in a neighboring room, pumped infrasound at approximately 18 Hz into half those spaces. The participants had no idea. That last point turned out to be rather important. When the team ran the numbers, they found that participants couldn't reliably identify whether infrasound had been present. Their guesses were, statistically speaking, no better than chance. And according to Schmaltz, participants' beliefs about whether the infrasound was on had no detectable effect on their cortisol or mood. The physiological response didn't care what the participants thought was happening. It just happened anyway.

What happened, specifically, was this: those exposed to infrasound reported higher irritability, lower interest in the music, and a tendency to rate the music as sadder, irrespective of whether it was the calming or the horror track. Cortisol levels, measured before and about 20 minutes after exposure, were also elevated. Kale Scatterty, the PhD student who led the work, notes that irritability and cortisol do tend to move together under ordinary stress, but adds that "infrasound exposure had effects on both outcomes that went beyond that natural relationship." That distinction matters more than it might seem. Previous theories about infrasound and paranormal experience have often leaned on anxiety as the explanatory mechanism, the idea that low-frequency sound triggers a kind of free-floating dread that the mind then reaches for supernatural explanations to account for. The new data don't really support that picture. Measures of anxiety didn't budge significantly. What went up was irritability and disinterest, a kind of sour, low-grade aversion rather than fear. That's perhaps a more honest description of how a lot of ghost stories actually feel in the telling: not screaming terror, but wrong atmosphere, a sense of unease that never quite crystallizes into something you can point at.
The study has been published this week in Frontiers in Behavioral Neuroscience.
NASA

New Problem for NASA's 'Lunar Gateway': Corrosion in Two Modules Caused by Supplier (arstechnica.com) 34

In March, NASA Administrator Jared Isaacman announced that the moon-orbiting "Lunar Gateway" space station was being "paused" to focus instead of missions to the moon's surface. And Ars Technica agrees that the project was essentially "spending billions of dollars to make it more difficult to reach the lunar surface and faced the prospect of watching Chinese astronauts wander around on the Moon from orbit instead of being there themselves."

"But this week, we learned another reason that Gateway is going away, and it's pretty shocking." During testimony before the US House Committee on Science, Space, and Technology, Isaacman faced questions about NASA's budget... He then publicly confirmed rumors (reported last month by Ars) that there is corrosion in both the HALO [Habitation and Logistics Outpost] and I-HAB modules of the Gateway. "The only two habitable volumes that were delivered — both were corroded," Isaacman said. "And that's unfortunate because it would have delayed, probably beyond 2030, the application of Gateway...."

In a statement, Northrop confirmed the issue as well. "Using NASA-approved processes, Northrop Grumman is completing repairs to HALO after a manufacturing irregularity," a company spokesperson told Ars. "We expect to complete repairs by the end of the third quarter. HALO can still be repurposed for any mission, and it's the most mature technology to support a deep space or lunar habitat." By referring to a "manufacturing irregularity," Northrop answered the central mystery here: how corrosion could appear in both modules. This is because a French-Italian space and defense company, Thales Alenia Space, built the primary structure of HALO for Northrop Grumman. The module was delivered from Italy to the United States about a year ago

Thales is a powerhouse of the European space industry. It built several pressurized modules of the International Space Station, and it's working with Axiom Space to build its commercial space station. The company also had a big piece of the Lunar Gateway in addition to HALO, developing the I-HAB module and a future communications and refueling module known as ESPRIT... After the issue was discovered, the European Space Agency established a "tiger team" to investigate. "Based on the investigation and available data, the corrosion issue was understood to be technically manageable and did not constitute a showstopper for I-HAB, which was, in any case, in better conditions than HALO from [a] corrosion point of view," the spokesperson said...

After publication of this story on Friday, Axiom Space confirmed that it has also experienced corrosion issues. In a statement, the company said: "Axiom Space has experienced a similar phenomenon with the first module; we are leveraging the expertise of NASA and Thales Alenia Space to address the issue. Module 1 is on track to launch in 2028."

Science

Physicists Revive 1990s Laser Concept To Propose a Next-Generation Atomic Clock 19

Physicists have proposed a new kind of atomic clock based on a revived superradiant laser concept that could produce an extraordinarily stable signal with a linewidth around 100 microhertz, potentially the narrowest ever for an optical laser. "The implications of this result could stretch well beyond timekeeping," reports Phys.org. "A laser immune to environmental frequency shifts would be a powerful tool in optical interferometry -- using interference patterns in light to make ultra-precise measurements." From the report: In a conventional laser, a mirrored cavity bounces light back and forth between atoms, building up a bright, coherent beam. A superradiant laser works differently: rather than relying on the cavity to maintain coherence, the atoms themselves act as single coordinated emitters, collectively synchronizing their light emission. Following early theoretical ideas emerged in the 1990s, the concept didn't gain concrete traction until 2008, when researchers at the University of Colorado proposed that superradiant lasers could serve as a new kind of atomic clock.

Atomic clocks work by using laser light to probe a very precise transition in an atom, causing electrons to transition between energy levels at an extraordinarily stable frequency. Because a superradiant laser stores its coherence in the atoms rather than the cavity, its output frequency is far less vulnerable to environmental disturbances like vibrations or temperature fluctuations. Yet although this concept was first demonstrated experimentally in 2012 in a pulsed regime, the influence of heating has so far held superradiant lasers back from their full potential. To keep the laser running continuously as an atomic clock requires, atoms must be constantly replenished with energy. Doing this atom-by-atom delivers random kicks that heat the atomic sample and disrupt the lasing process, confining it to brief pulses rather than a steady beam.

In their study, Reilly's team considered whether a modification to earlier theoretical concepts could make a continuous laser suitable for an atomic clock. In almost all previous studies, atoms were treated as simple two-level systems: an electron sitting in a ground state, occasionally jumping up to an excited state and back again. The team proposed that the heating problem could be solved by adding one extra ground state to the picture. In a two-level system, if both the pumping (re-energizing) and decay processes happen collectively through the cavity, the mathematics constrains the system in a way that prevents stable, continuous lasing. But with three levels available, pumping and decay can operate on entirely separate transitions, breaking that constraint and allowing the collective approach to work.
The findings have been published in the journal Physical Review Letters.
Medicine

FDA Gives Green Light To the First Gene Therapy For Deafness (npr.org) 33

An anonymous reader quotes a report from NPR: The Food and Drug Administration approved the first gene therapy to restore hearing for people who were born deaf. The decision, while only immediately affecting people born with a very rare form of genetic deafness, is being hailed as a milestone in the quest to treat hearing loss. "It's the first time in history there's a new drug for hearing loss," says Zheng-Yi Chen, an associate scientist at Mass Eye and Ear in Boston who was not involved in the development of the therapy approved by the FDA Thursday. But his research team reported very promising results with a similar approach Wednesday. "I think it's an historical event, a landmark, a great development for the whole field," he says of the approval. [...] The FDA's decision was based on the results from the treatment of 20 patients born with a defective version of a gene known as OTOF, which is necessary to transmit sound from the ears to the brain.

Doctors infused billions of adeno-associated viruses into the patients' ears by making a small incision behind the ear to open a small hole in the skull. The viruses carried a healthy version of the OTOF gene that had been split in half to fit inside the virus. The gene provides instructions to make the otoferlin protein, which is necessary for hair cells in the inner ear to transmit sound to the brain. Most of the patients began to hear for the first time within weeks, with the quality of their hearing improving over the following months, according to [Regeneron Pharmaceuticals, which developed the gene therapy and plans to offer it for free in the U.S. It should be available within weeks.]. The amount of hearing patients gained varied, but 80% achieved at least some significant hearing restoration and 42% ended up with normal hearing, which included the ability to hear whispers, Regeneron says. The hearing ability has lasted at least two years so far.

The treatment can only help patients with the very rare form of deafness that Smith was born with, which only affects about 50 children each year in the U.S. But similar gene therapies are showing promise for other forms of genetic deafness. And researchers hope someday gene therapy may help with common types of hearing loss, like from aging and loud noise.

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