Scientists Partially Restored a Blind Man's Sight With New Gene Therapy (nytimes.com) 10
An anonymous reader quotes a report from The New York Times: A team of scientists announced Monday that they had partially restored the sight of a blind man by building light-catching proteins in one of his eyes. Their report, which appeared in the journal Nature Medicine, is the first published study to describe the successful use of this treatment. The procedure is a far cry from full vision. The volunteer, a 58-year-old man who lives in France, had to wear special goggles that gave him the ghostly perception of objects in a narrow field of view. But the authors of the report say that the trial -- the result of 13 years of work -- is a proof of concept for more effective treatments to come.
The scientists are taking advantage of proteins derived from algae and other microbes that can make any nerve cell sensitive to light. In the early 2000s, neuroscientists figured out how to install some of these proteins into the brain cells of mice and other lab animals by injecting viruses carrying their genes. The viruses infected certain types of brain cells, which then used the new gene to build light-sensitive channels. Originally, researchers developed this technique, called optogenetics, as a way to probe the workings of the brain. By inserting a tiny light into the animal's brain, they could switch a certain type of brain cell on or off with the flick of a switch. The method has enabled them to discover the circuitry underlying many kinds of behavior.
The scientists are taking advantage of proteins derived from algae and other microbes that can make any nerve cell sensitive to light. In the early 2000s, neuroscientists figured out how to install some of these proteins into the brain cells of mice and other lab animals by injecting viruses carrying their genes. The viruses infected certain types of brain cells, which then used the new gene to build light-sensitive channels. Originally, researchers developed this technique, called optogenetics, as a way to probe the workings of the brain. By inserting a tiny light into the animal's brain, they could switch a certain type of brain cell on or off with the flick of a switch. The method has enabled them to discover the circuitry underlying many kinds of behavior.
Ooh shiny! (Score:2)
The method has enabled them to discover the circuitry underlying many kinds of behavior.
We'll finally find out why disco was popular.
I'm conflicted. (Score:2, Flamebait)
It's super great that scientists are developing these groundbreaking therapies but I really think it's awful that they are going around blinding volunteers. ;)
Imagine combining them with a gene drive virus! (Score:1)
Suddenly, ALL neurons can see. Of all humans. Forever!
Now *that* is an evil sci-fi nightmare! ;)
Re: (Score:2)
Virus (Score:2)